@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTW6: (2017-12-15 )
MAIPQHTIDQILDRTDIVDLIGQRVKLKKTGRTYSGCCPFHQEKTPSFHVYRDKQYYHCFGCQANGNAIRFLMDIDNRNFIDVMKELSSNTGVELPKDNTDNKKLSYTRQVTKPSTPPKMVAEPTTQAPIEDQYNTFDPVYFDDPFAQFEQPFSFDEPVQEGNLYDLLENVAQFYEHQLPTSQKAKNYFKQRGLSDQTIQFWRLGYAPEDWQHLEKAFPYDIEGLKQLGLIRSSDSGRDFDLLRDRVIFPIRDPKGRVVGFGGRALNDEIKPKYINSPDSEVFHKNQLLYGLYEGRKLKANDWLMVEGYMDVIALQQYGITGAVATLGTASNTEHLNILFKQNNRITIAFDGDAAGQKAARRTLEIALPLLNDGRELKFFVLPNDHDPDSLIRREGVENFQKLLQQAPLLSDFVFAHLTGQHDISTPEGKSLVMGELRELTELLPKQGSFRYLLTQSFREKLGLGKRFTPQISHDASLSFNIQTKDEDFAIAILMHHPFLYIHFEGLRAYIPQDELLAKILAILNRIFDELPDDQELATYYVLGACSSYCHEIADIMQRTNIQALTQAPEVADKLAKEYALGLQERYLRQKLKSKISLVESRNLRQQLNELTKQISLRLLS
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........-90........100.......110.......120.......130.......140.......150.......160.......170.......---180--.---.......190.......200.......210......----.---220-........----230.-...-....240.......250.......260.......270.......280.......290.....--.--.300.--..-......310.......320.......330.......340.......350.......360.......370.......380.......390.......400....-..-..-410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAI
P
Q
H
T
I
D
Q
I
L
D
R
T
D
I
V
D
L
I
GQ
R
V
K
L
KKTGRTYSGCCPFHQEKTPS
F
H
V
Y
R
D
K
Q
Y
Y
H
C
F
GCQANG
N
A
I
R
F
L
M
DIDN
R
N
F
I
D
V
M
K
E
L
SS-NTGVELPKDNTDNK
K
L
S
Y
T
R
QVTKPSTPPKMVAEPTTQAPIEDQYNTFDPVYFDD
P
F
A
Q
FEQPFSFDEPVQEG
N
L
Y
D
L
L
E
N
V
A
Q
F
Y
E
HQL---P
T
---
S
---
Q
K
A
K
N
Y
F
K
QRGLSDQ
T
I
Q
F
W
RLGYAP
E
D
W
Q
H
L
E
K
AF----P---Y
D
--
I
E
G
L
K
QLG----
L
I
-R-SSD-SGR
D
F
D
L
L
RD
R
V
I
F
P
IRDPKG
R
V
V
G
FGGRALNDEIKPKYINSP
D
S
E
V
F
H
KN
Q
L
L
Y
G
LYEGRK--L--KA--N--
D
W
-
L
M
V
E
G
Y
M
D
V
I
A
L
Q
QYGIT
G
A
V
ATLGTASNT
E
H
L
N
I
L
F
KQN
N
R
I
T
I
A
FDGDAA
G
Q
K
A
A
R
R
T
L
E
I
A
LPLLNDG
R
E
L
K
F
F
V
LPNDH
D
P
D
S
L
I
R
R
E
G
V
E
N
F
Q
-
K
L
L
Q
-QA-P
L
-
L
S
D
F
V
F
A
H
LTGQHDISTPEGK
S
L
V
M
G
E
L
R
E
L
T
E
LLPKQG
S
F
R
Y
L
L
T
Q
S
F
R
E
KLGLGKRFTPQISHDA
S
L
S
F
N
I
Q
TKDE
D
F
A
I
A
I
L
MHH
P
F
L
Y
I
H
F
E
G
L
R
A
YI
P
Q
D
E
L
L
A
K
I
L
A
I
L
N
R
I
F
D
ELPD
D
Q
E
L
A
T
Y
Y
V
L
G
A
C
S
S
Y
C
H
E
I
A
D
I
M
Q
RT
N
I
Q
A
L
TQA
P
E
V
A
D
K
L
A
K
E
Y
A
L
G
L
Q
E
R
Y
L
R
Q
K
L
K
S
K
I
S
L
V
E
S
R
N
L
R
Q
Q
L
N
E
L
T
K
Q
I
S
L
RLLS
22
HHSearch
79.75
34%
-5
* C4 *
-
2AU3
-
DNAG_AQUAE
A:
[3-403]
---
M
S
S
D
I
D
E
L
R
R
E
I
D
I
V
D
V
I
S
E
Y
L
N
L
E
K
V
G
S
N
Y
R
T
N
C
P
F
H
P
D
D
T
P
S
F
Y
V
S
P
S
K
Q
I
F
K
C
F
G
C
G
V
G
G
D
A
I
K
F
V
S
L
Y
E
D
I
S
Y
F
E
A
A
L
E
L
A
K
-
R
Y
G
K
K
L
D
L
E
K
I
S
----------------------------------------------------------
K
D
E
K
V
Y
V
A
L
D
R
V
C
D
F
Y
R
E
S
L
---
L
K
---
N
---
R
E
A
S
E
Y
V
K
S
R
G
I
D
P
K
V
A
R
K
F
D
L
G
Y
A
P
S
S
-
E
A
L
V
K
V
L
----
K
E
N
D
L
L
--
E
A
Y
L
E
T
K
N
----
L
L
-
S
-
P
T
--
K
G
V
Y
R
D
L
F
L
R
R
V
V
I
P
I
K
D
P
R
G
R
V
I
G
F
G
G
R
R
I
V
E
D
K
S
P
K
Y
I
N
S
P
D
S
R
V
F
K
K
G
E
N
L
F
G
L
Y
E
A
K
E
Y
I
K
--
E
E
--
G
--
F
A
-
I
L
V
E
G
Y
F
D
L
L
R
L
F
S
E
G
I
R
N
V
V
A
P
L
G
T
A
L
T
Q
N
Q
A
N
L
L
S
K
F
T
K
K
V
Y
I
L
Y
D
G
D
D
A
G
R
K
A
M
K
S
A
I
P
L
L
L
---
S
A
G
V
E
V
Y
P
V
Y
L
P
E
G
Y
D
P
D
E
F
I
K
E
F
G
K
E
E
L
R
-
R
L
I
N
-
S
S
-
G
E
-
L
F
E
T
L
I
K
T
A
R
E
N
L
E
-----
E
---
K
T
R
E
F
R
Y
Y
L
G
F
I
S
D
-
G
V
R
R
F
A
L
A
S
E
F
H
T
K
Y
K
V
P
M
E
I
L
L
M
------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.71
44%
35
- C4 -
-
5VAZ
-
DNAG_PSEAE
A:
[20-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
P
L
L
S
A
A
A
E
F
Y
K
Q
A
L
K
SH
P
A
---
R
---
K
A
A
V
N
Y
L
K
G
R
G
L
T
G
E
I
A
R
D
F
G
L
G
F
A
P
P
G
W
D
N
L
L
K
H
L
----
G
---
G
D
--
N
L
Q
L
K
A
M
L
D
A
GL
L
V
-
E
-
N
S
D
-
T
G
K
R
Y
D
R
F
R
D
R
V
M
F
P
I
R
D
S
R
G
R
I
I
A
F
G
G
R
V
L
G
D
D
-
K
P
K
Y
L
N
S
P
E
T
P
V
F
H
K
G
Q
E
L
Y
G
L
Y
E
A
R
Q
--
K
--
N
R
--
D
LD
E
I
-
M
V
V
E
G
Y
M
D
V
I
A
L
A
Q
Q
G
I
R
N
A
V
A
T
L
G
T
A
T
S
E
E
H
I
K
R
L
F
R
L
V
P
S
I
L
F
C
F
D
G
D
Q
A
G
R
K
A
A
W
R
A
L
E
S
V
L
P
N
L
Q
D
G
K
R
V
R
F
L
F
L
P
E
G
E
D
P
D
S
L
V
R
A
E
G
E
D
A
F
R
A
R
I
T
Q
-
Q
A
-
Q
P
-
L
A
E
Y
F
F
Q
Q
L
M
L
E
A
D
P
A
T
L
E
G
K
A
H
L
A
T
L
A
A
P
L
L
E
K
I
P
G
N
-
N
L
R
L
L
M
R
Q
R
L
S
E
I
T
G
L
S
G
E
N
I
G
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.57
43%
54
- C4 -
-
1EQN
-
DNAG_ECOLI
A:
[113-421]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
T
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
Q-
P
V
---
A
---
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
W
D
N
V
L
K
R
F
GGN-
P
---
E
N
--
R
Q
S
L
I
D
A
G
----
M
L
-
V
-
T
N
D
-
Q
G
R
S
Y
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
D
T
-
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
--
D
--
N
A
EP
N
--
R
L
-
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
T
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
R
A
L
E
T
A
L
P
Y
M
T
D
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
-
A
R
M
E
-
Q
A
-
M
P
-
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
P
G
E
-
T
L
R
I
Y
L
R
Q
E
L
G
N
K
L
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
72.52
44%
39
- C4 -
-
5VAZ
-
DNAG_PSEAE
B:
[19-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
Y
P
L
L
S
A
A
A
E
F
Y
K
Q
A
L
---
K
S
HPA
R
---
K
A
A
V
N
Y
L
K
G
R
G
L
T
G
E
I
A
R
D
F
G
L
G
F
A
P
P
G
W
D
N
L
L
K
H
L
----
G
GD
N
L
Q
--
L
K
A
M
L
D
A
G
----
L
L
-
V
-
E
N
S
D
T
G
K
R
Y
D
R
F
R
D
R
V
M
F
P
I
R
D
S
R
G
R
I
I
A
F
G
G
R
V
L
G
D
D
-
K
P
K
Y
L
N
S
P
E
T
P
V
F
H
K
G
Q
E
L
Y
G
L
Y
E
A
R
Q
K
N
R
--
D
L
--
D
--
E
I
-
M
V
V
E
G
Y
M
D
V
I
A
L
A
Q
Q
G
I
R
N
A
V
A
T
L
G
T
A
T
S
E
E
H
I
K
R
L
F
R
L
V
P
S
I
L
F
C
F
D
G
D
Q
A
G
R
K
A
A
W
R
A
L
E
S
V
L
P
N
L
Q
D
G
K
R
V
R
F
L
F
L
P
E
G
E
D
P
D
S
L
V
R
A
E
G
E
D
A
F
R
-
A
R
I
T
Q
Q
A
-
Q
P
-
L
A
E
Y
F
F
Q
Q
L
M
L
E
A
D
P
A
T
L
E
G
K
A
H
L
A
T
L
A
A
P
L
L
E
K
I
P
G
-
N
N
L
R
L
L
M
R
Q
R
L
S
E
I
T
G
L
S
G
E
N
I
G
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.94
43%
58
- C4 -
-
3B39
2
DNAG_ECOLI
A:
[5-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
T
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
Q-
P
V
---
A
---
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
W
D
N
V
L
K
R
F
GGN-
P
---
E
N
--
R
Q
S
L
I
D
A
G
----
M
L
-
V
-
T
N
D
---
R
S
Y
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
D
T
-
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
--
D
--
N
A
EP
N
--
R
L
-
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
T
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
C
A
L
E
T
A
L
P
Y
M
T
D
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
-
A
R
M
E
-
Q
A
-
M
P
-
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
P
G
E
-
T
L
R
I
Y
L
R
Q
E
L
G
N
K
L
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
71.81
43%
55
- C4 -
-
1DD9
-
DNAG_ECOLI
A:
[20-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
Q-
P
V
---
A
---
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
W
D
N
V
L
K
R
F
GGN-
P
---
E
N
--
R
Q
S
L
I
D
A
G
----
M
L
-
V
-
T
----
N
R
S
Y
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
D
-
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
--
D
NA
E
P
--
N
--
R
L
-
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
S
T
T
-
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
R
A
L
E
T
A
L
P
Y
M
T
D
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
-
A
R
M
E
-
Q
A
-
M
P
-
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
P
G
-
E
T
L
R
I
Y
L
R
Q
E
L
G
N
K
L
G
I
L
D
D
S
Q
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
71.68
43%
63
- C4 -
-
3B39
1
DNAG_ECOLI
B:
[5-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
T
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
Q-
P
V
---
A
---
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
W
D
N
V
L
K
R
F
GGN-
P
---
E
N
--
R
Q
S
L
I
D
A
G
----
M
L
-
V
-
T
N
D
-
Q
G
R
S
Y
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
D
T
-
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
--
D
--
N
A
EP
N
--
R
L
-
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
T
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
C
A
L
E
T
A
L
P
Y
M
T
D
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
-
A
R
M
E
-
Q
A
-
M
P
-
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
P
G
E
-
T
L
R
I
Y
L
R
Q
E
L
G
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
71.46
43%
56
- C4 -
-
3B39
2
DNAG_ECOLI
A:
[5-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
T
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
---
Q
Q
PV-
A
---
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
W
D
N
V
L
K
R
F
----
G
GN
P
E
N
--
R
Q
S
L
I
D
A
G
----
M
L
-
V
-
T
N
D
---
R
S
Y
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
D
-
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
--
E
P
--
N
--
R
L
-
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
T
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
C
A
L
E
T
A
L
P
Y
M
T
D
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
-
A
R
M
E
-
Q
A
-
M
P
-
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
P
G
-
E
T
L
R
I
Y
L
R
Q
E
L
G
N
K
L
G
I
L
D
D
S
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.30
31%
12
- C4 -
-
2AU3
-
DNAG_AQUAE
A:
[7-348]
-------
I
D
E
L
R
R
E
I
D
I
V
D
V
I
S
E
Y
L
N
L
E
K
V
G
S
N
Y
R
T
N
C
P
F
H
P
D
D
T
P
S
F
Y
V
S
P
S
K
Q
I
F
K
C
F
G
C
G
V
G
G
---------
D
A
I
K
F
V
S
L
Y
E
D
I
S
Y
F
E
A
A
L
E
L
A
K
--------------------------------------------------
R
Y
G
K
K
L
D
L
E
K
I
S
K
D
E
K
V
Y
V
A
L
D
R
V
C
D
F
Y
R
E
S
L
---
L
K
---
N
---
R
E
A
S
E
Y
V
K
S
R
G
I
D
P
K
V
A
R
K
F
D
L
G
Y
A
P
S
S
-
E
A
L
V
K
V
L
----
K
---
E
N
DL
L
E
A
Y
L
E
T
K
----
N
L
-
L
-
S
P
T
-
K
G
V
Y
R
D
L
F
L
R
R
V
V
I
P
I
K
D
P
R
G
R
V
I
G
F
G
G
R
R
I
V
E
D
K
S
P
K
Y
I
N
S
P
D
S
R
V
F
K
K
G
E
N
L
F
G
L
Y
E
A
K
E
Y
-
I
--
K
E
--
E
--
G
F
A
I
L
V
E
G
Y
F
D
L
L
R
L
F
S
E
G
I
R
N
V
V
A
P
L
G
T
A
L
T
Q
N
Q
A
N
L
L
S
K
F
T
K
K
V
Y
I
L
Y
D
G
D
D
A
G
R
K
A
M
K
S
A
I
P
L
---
L
L
S
A
G
V
E
V
Y
P
V
Y
L
P
E
G
Y
D
P
D
E
F
I
K
E
F
G
K
E
E
L
R
-
R
L
I
N
-
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
69.34
43%
55
- C4 -
-
1DD9
-
DNAG_ECOLI
A:
[20-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
Q-
P
V
---
A
---
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
W
D
N
V
L
K
R
F
GGN-
P
---
E
N
--
R
Q
S
L
I
D
A
G
----
M
L
-
V
-
T
N
----
R
S
Y
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
D
T
-
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
--
D
--
N
A
EP
N
--
R
L
-
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
-
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
R
A
L
E
T
A
L
P
Y
M
T
D
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
-
A
R
M
E
-
Q
A
-
M
P
-
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
P
G
E
-
T
L
R
I
Y
L
R
Q
E
L
G
N
K
L
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
69.16
43%
54
- C4 -
-
1DD9
-
DNAG_ECOLI
A:
[20-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
---
Q
Q
PV-
A
---
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
W
D
N
V
L
K
R
F
----
G
GN
P
E
N
--
R
Q
S
L
I
D
A
G
----
M
L
-
V
-
T
N
----
R
S
Y
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
D
-
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
--
E
P
--
N
--
R
L
-
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
-
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
R
A
L
E
T
A
L
P
Y
M
T
D
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
-
A
R
M
E
-
Q
A
-
M
P
-
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
P
G
-
E
T
L
R
I
Y
L
R
Q
E
L
G
N
K
L
G
I
L
D
D
S
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.12
43%
54
- C4 -
-
1DDE
-
DNAG_ECOLI
A:
[20-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
Q-
P
V
---
A
---
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
W
D
N
V
L
K
R
F
GGN-
P
---
E
N
--
R
Q
S
L
I
D
A
G
----
M
L
-
V
-
T
N
----
R
S
Y
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
D
T
-
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
--
D
--
N
A
EP
N
--
R
L
-
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
T
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
R
A
L
E
T
A
L
P
Y
M
T
D
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
-
A
R
M
E
-
Q
A
-
M
P
-
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
P
G
E
-
T
L
R
I
Y
L
R
Q
E
L
G
N
K
L
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
62.24
27%
29
- C4 -
-
5GUJ
-
DNAG_BACSU
A:
[4-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
M
A
E
A
H
E
L
L
K
K
F
Y
H
H
L
L
---
I
N
TKE
G
---
Q
E
A
L
D
Y
L
L
S
R
G
F
T
K
E
L
I
N
E
F
Q
I
G
Y
A
L
D
S
W
D
F
I
T
K
F
L
----
V
K
R
G
F
S
--
E
A
Q
M
E
K
A
G
----
L
L
-
I
-
R
R
E
D
G
S
G
Y
F
D
R
F
R
N
R
V
M
F
P
I
H
D
H
H
G
A
V
V
A
F
S
G
R
A
L
G
S
Q
-
Q
P
K
Y
M
N
S
P
E
T
P
L
F
H
K
S
K
L
L
Y
N
F
Y
K
A
R
L
H
I
R
--
K
Q
--
E
--
R
A
-
V
L
F
E
G
F
A
D
V
I
S
A
V
S
S
D
V
K
E
S
I
A
T
M
G
T
S
L
T
D
D
H
V
K
I
L
R
R
N
V
E
E
I
I
L
C
Y
D
S
D
K
A
G
Y
E
A
T
L
K
A
S
E
L
L
Q
---
K
K
G
C
K
V
R
V
A
M
I
P
D
G
L
D
P
D
D
Y
I
K
K
F
G
G
E
K
F
K
-
N
D
I
I
D
A
S
-
V
T
-
V
M
A
F
K
M
Q
Y
F
R
K
G
K
N
L
S
D
E
G
D
R
L
A
Y
I
K
D
V
L
K
E
I
S
T
L
S
G
-
S
L
E
Q
E
V
Y
V
K
Q
L
A
S
E
F
S
L
S
Q
E
S
L
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
60.73
28%
37
- C4 -
-
4EDK
4
DNAG_STAAU
A:
[5-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
Q
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
---
T
K
TVE
G
---
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
D
S
S
H
F
C
H
D
F
L
----
Q
K
K
G
Y
D
--
I
E
L
A
Y
E
A
G
----
L
L
-
S
-
R
N
E
E
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
Q
-
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
--
K
L
--
D
--
E
I
-
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
T
L
K
T
G
Q
H
L
L
---
Q
Q
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
-
T
F
V
K
-
N
D
K
K
S
-
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
H
-
N
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
K
S
-
S
I
L
Q
Q
K
A
I
N
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
59.22
27%
37
- C4 -
-
4EDK
4
DNAG_STAAU
A:
[1-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
A
D
D
L
Q
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
---
T
K
---
T
VEG
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
D
S
S
H
F
C
H
D
F
L
----
Q
K
K
G
Y
D
--
I
E
L
A
Y
E
A
G
----
L
L
-
S
R
N
E
E
-
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
Q
-
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
--
K
L
--
D
--
E
I
-
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
T
L
K
T
G
Q
H
L
L
Q
---
Q
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
-
T
F
V
K
-
N
D
-
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
H
N
-
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
K
S
-
S
I
L
Q
Q
K
A
I
N
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
55.83
54%
-194
- C4 -
-
1D0Q
-
DNAG_GEOSE
A:
[5-97]
--
I
P
E
E
T
I
E
A
I
R
R
G
V
D
I
V
D
V
I
G
E
Y
V
Q
L
K
R
Q
G
R
N
Y
F
G
L
C
P
F
H
G
E
K
T
P
S
F
S
V
S
P
E
K
Q
I
F
H
C
F
G
C
G
A
G
G
N
A
F
T
F
L
M
D
I
E
G
I
P
F
V
E
A
A
K
R
L
A
A
-
K
A
G
V
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
55.58
34%
50
- C4 -
-
4EE1
2
DNAG_STAAU
A:
[8-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
---
T
K
---
T
VEG
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
-
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
---
Y
D
--
I
E
L
A
Y
E
A
G
----
L
L
S
R
-
N
E
E
-
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
Q
-
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
--
K
L
--
D
--
E
I
-
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
Q
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
-
T
F
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
55.58
34%
50
- C4 -
-
4EDV
2
DNAG_STAAU
A:
[8-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
---
T
K
---
T
VEG
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
-
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
---
Y
D
--
I
E
L
A
Y
E
A
G
----
L
L
S
R
-
N
E
E
-
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
Q
-
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
--
K
L
--
D
--
E
I
-
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
Q
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
-
T
F
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
55.43
53%
-189
- C4 -
-
1D0Q
-
DNAG_GEOSE
A:
[4-99]
-
R
I
P
E
E
T
I
E
A
I
R
R
G
V
D
I
V
D
V
I
G
E
Y
V
Q
L
K
R
Q
G
R
N
Y
F
G
L
C
P
F
H
G
E
K
T
P
S
F
S
V
S
P
E
K
Q
I
F
H
C
F
G
C
G
A
G
G
N
A
F
T
F
L
M
D
I
E
G
I
P
F
V
E
A
A
K
R
L
A
A
-
K
A
G
V
D
L
S
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
55.24
34%
49
- C4 -
-
4EDR
4
DNAG_STAAU
A:
[8-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
---
T
K
---
T
VEG
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
-
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
---
Y
D
--
I
E
L
A
Y
E
A
G
----
L
L
S
R
-
N
E
E
-
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
Q
-
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
--
K
L
--
D
--
E
I
-
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
Q
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
-
T
F
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
54.83
34%
50
- C4 -
-
4EDK
4
DNAG_STAAU
A:
[8-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
---
T
K
---
T
VEG
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
-
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
---
Y
D
--
I
E
L
A
Y
E
A
G
----
L
L
S
R
-
N
E
E
-
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
Q
-
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
--
K
L
--
D
--
E
I
-
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
Q
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
-
T
F
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
54.57
34%
50
- C4 -
-
4EDT
2
DNAG_STAAU
A:
[8-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
---
T
K
---
T
VEG
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
-
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
---
Y
D
--
I
E
L
A
Y
E
A
G
----
L
L
S
R
-
N
E
E
-
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
Q
-
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
--
K
L
--
D
--
E
I
-
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
Q
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
-
T
F
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
54.56
34%
51
- C4 -
-
4EDG
3
DNAG_STAAU
A:
[8-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
---
T
K
---
T
VEG
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
-
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
---
Y
D
--
I
E
L
A
Y
E
A
G
----
L
L
S
R
-
N
E
E
-
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
Q
-
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
--
K
L
--
D
--
E
I
-
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
Q
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
-
T
F
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------