@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VU35: (2017-12-16 )
MFDHIAQPISYQHIELSFPVHLDIKRLDLVHPQISGNKFFKLKYNLLAAKEQGLSSILTFGGAYSNHIAATAYAAHLFGLKSIGIIRGEELAGKPLNPTLAKAQSLGMQLHFVSRHEYRLRDEANYLKQLQQQFPQTYIIPEGGTNELAVQGCQEILSQYDLEQYDVICCAVGTGGTISGLIERSAAHQKVLGFSALKGDFLQQEIKQWTKKQNWSLTDVYCWGGYAKTSPELFTFIENFEEQYTVPLEPIYTGKMMFGLFDLIKNNYFPANTRILAIHSGGLQADIRNRSHA
Atome Classification :
(20 SA)
------------.........10-......---.--.--20........30.-.-..--..-..40........50........60-.........70........80.......-.90-..---.------.....------.100.....-..110.....--.--.120-...----------.---...-..130--....-.....140..-.-..-----..----150-----------.......160.------...--...170.......180----------------......---.---.190-...-----..-..-.200-.-.-...----.-------.-------.-------210------------.---------------.....---..220----.........230.......240.......250.......260.......270.......280.......290.-----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------MFDHIAQPI
S
Y
-
Q
H
I
E
L
S---F--
P
--
V
H
L
D
I
K
R
L
D
L
VHP-Q-IS--G
N
-
K
F
F
K
L
K
Y
N
L
L
A
A
K
E
Q
G
L
S
S
I
L
T
F--GGAYSN
H
I
A
A
T
A
Y
A
A
H
L
F
G
L
K
S
I
G
I
I
RG-
E
E
--LA---G------KPLN
P
------
T
L
A
K
A
Q
SLG-
M
Q
L
H
F
VSRH
E
--
Y
--RL---
R
D
E
----------
A
---
N
Y
L
-
K
Q
L
----
Q
Q
QF-PQ
T
Y
I
IPEGG-T-
N
E
-----
L
A
----
V
Q
G
-----------
C
Q
E
I
L
S
QYDLE------QY
D
--
V
I
C
C
AVGTG
G
T
I
S
G
L
-----------------
I
E
R
S
A
A
---
H
---
Q
K
V
--L
G
F
-----
S
A
-
L
K
-
G
D
-
F
-
L
-
Q
-
Q
E
I
----
K
-------
Q
-------
W
-------
T
K-------------K---------------QNWSL---
T
D
V
------
Y
CWGGYAKT
S
P
E
L
F
T
F
I
E
N
F
E
E
QYTVPLEPIYTG
K
M
M
F
G
L
F
D
L
I
KNNYFPAN
T
R
I
L
A
I
HSGG
L
Q
A
DIRNRSHA-----
2
PsiBlast_PDB
94.23
29%
0
- C- -
-
1J0B
1
1A1D_PYRHO
A:
[23-313]
-------------------
P
I
Q
Y
L
P
N
I
S
R
E
---
I
--
G
--
A
D
V
Y
I
K
R
D
D
L
T
G
L
-
G
-
I
G
--
G
N
-
K
I
R
K
L
E
Y
L
L
G
D
A
L
S
K
G
A
D
V
V
I
T
V
--
G
A
V
H
S
N
H
A
F
V
T
G
L
A
A
K
K
L
G
L
D
A
I
L
V
L
R
G
K
E
E
--
L
K
---
G
---------
N
Y
------
L
L
D
K
I
M
G
I
E
-
T
R
V
-
Y
D
A
K
D
S
--
F
--
E
L
---
M
K
Y
----------
A
---
E
E
I
A
E
E
L
----
K
R
E
G
-
R
K
P
Y
V
I
P
P
G
G
-
A
-
S
P
-----
I
G
TL
G
Y
V
R
A
-----------
V
G
E
I
A
T
Q
S
E
V
-------
K
F
D
--
S
I
V
V
A
A
G
S
G
G
T
L
A
G
L
S
----------------
L
G
L
S
I
L
---
N
---
E
D
I
RP
V
G
I
-----
A
V
-
G
R
F
G
E
-
V
-
M
-
T
-
S
K
L
----
D
-------
N
-------
L
-------
I
K
-------------
E
---------------
A
A
E
L
L
GVK
V
E
V
R
P
E
L
Y
D
Y
S
F
G
E
Y
G
K
I
T
G
E
V
A
Q
I
I
R
K
V
G
T
R
E
G
I
I
L
D
P
V
Y
T
G
K
A
F
Y
G
L
V
D
L
A
R
K
G
E
L
--
G
E
K
I
L
F
I
H
T
G
G
I
S
G
-------------
1
PsiBlast_PDB
80.95
29%
-20
- C8 -
-
1J0A
1
1A1D_PYRHO
A:
[23-313]
-------------------
P
I
Q
Y
L
P
N
I
S
R
E
---
I
--
G
--
A
D
V
Y
I
K
R
D
D
L
T
G
L
-
G
-
I
G
--
G
N
-
K
I
R
K
L
E
Y
L
L
G
D
A
L
S
K
G
A
D
V
V
I
T
V
--
G
A
V
H
S
N
H
A
F
V
T
G
L
A
A
K
K
L
G
L
D
A
I
L
V
L
R
G
K
E
E
--
L
K
---
G
---------
N
Y
------
L
L
D
K
I
M
G
I
E
-
T
R
V
-
Y
D
A
K
D
S
--
F
--
E
L
---
M
K
Y
----------
A
---
E
E
I
A
E
E
L
----
K
R
E
G
-
R
K
P
Y
V
I
P
P
G
G
-
A
-
S
P
-----
I
G
T
L
G
Y
V
R
A
-----------
V
G
E
I
A
T
Q
S
E
V
-------
K
F
D
--
S
I
V
V
A
A
G
S
G
G
T
L
A
G
L
S
----------------
L
G
L
S
I
L
---
N
---
E
D
I
RP
V
G
I
-----
A
V
-
G
R
F
G
E
-
V
-
M
-
T
-
S
K
L
----
D
-------
N
-------
L
-------
I
K
-------------
E
---------------
A
A
E
L
L
GVK
V
E
V
R
P
E
L
Y
D
Y
S
F
G
E
Y
G
K
I
T
G
E
V
A
Q
I
I
R
K
V
G
T
R
E
G
I
I
L
D
P
V
Y
T
G
K
A
F
Y
G
L
V
D
L
A
R
K
G
E
L
--
G
E
K
I
L
F
I
H
T
G
G
I
S
G
-------------
6
PsiBlast_PDB
78.77
28%
-26
- C8 -
-
4D9E
2
DCYD_SALTY
A:
[51-334]
-------------------------------------------
I
K
R
D
D
V
T
P
I
-
A
-
M
G
--
G
N
-
K
L
R
K
L
E
F
L
V
A
D
A
L
R
E
G
A
D
T
L
I
T
A
--
G
A
I
Q
S
N
H
V
R
Q
T
A
A
V
A
A
K
L
G
L
H
C
V
A
L
L
---
E
N
--
P
I
---
G
------
T
T
A
E
N
------
Y
L
T
N
G
N
R
L
L
-
L
D
L
-
F
N
T
Q
I
E
--
M
C
D
A
L
---
T
D
P
----------
D
---
A
Q
L
-
Q
T
L
A
T
R
I
E
A
Q
G
-
F
R
P
Y
V
I
P
V
G
G
-
S
-
S
A
-----
L
G
----
A
M
G
Y
V
E
S
A
L
E
I
A
Q
Q
C
E
E
V
V
G
------------
L
S
--
S
V
V
V
A
S
G
S
A
G
T
H
A
G
L
A
V
G
L
E
H
LMPD
V
E
L
I
G
V
T
V
S
R
S
V
A
---
E
---
Q
K
P
--------------
K
-
V
I
-
A
-
L
-
Q
-
Q
A
I
----
A
G
Q
L
----
A
-------
L
-------
T
A
-------------
T
---------------
A
D
I
H
L
---
W
D
D
------
Y
F
A
P
G
Y
G
V
P
N
D
A
G
M
E
A
V
K
L
L
A
S
L
E
G
V
L
L
D
P
V
Y
T
G
K
A
M
A
G
L
I
D
G
I
S
Q
K
R
F
N
D
D
G
P
I
L
F
I
H
T
G
G
A
P
A
-------------
4
PsiBlast_PDB
78.67
28%
-25
- C8 -
-
4D9B
4
DCYD_SALTY
A:
[51-334]
-------------------------------------------
I
K
R
D
D
V
T
P
I
-
A
-
M
G
--
G
N
-
K
L
R
K
L
E
F
L
V
A
D
A
L
R
E
G
A
D
T
L
I
T
A
--
G
A
I
Q
S
N
H
V
R
Q
T
A
A
V
A
A
K
L
G
L
H
C
V
A
L
L
---
E
N
--
P
I
---
G
------
T
T
A
E
N
------
Y
L
T
N
G
N
R
L
L
-
L
D
L
-
F
N
T
Q
I
E
--
M
C
D
A
L
---
T
D
P
----------
D
---
A
Q
L
-
Q
T
L
A
T
R
I
E
A
Q
G
-
F
R
P
Y
V
I
P
V
G
G
-
S
-
S
A
-----
L
G
----
A
M
G
Y
V
E
S
A
L
E
I
A
Q
Q
C
E
E
V
V
G
------------
L
S
--
S
V
V
V
A
S
G
S
A
G
T
H
A
G
L
A
V
G
L
E
H
LMPD
V
E
L
I
G
V
T
V
S
R
S
V
A
---
E
---
Q
K
P
--------------
K
-
V
I
-
A
-
L
-
Q
-
Q
A
I
----
A
G
Q
L
----
A
-------
L
-------
T
A
-------------
T
---------------
A
D
I
H
L
---
W
D
D
------
Y
F
A
P
G
Y
G
V
P
N
D
A
G
M
E
A
V
K
L
L
A
S
L
E
G
V
L
L
D
P
V
Y
T
G
K
A
M
A
G
L
I
D
G
I
S
Q
K
R
F
N
D
D
G
P
I
L
F
I
H
T
G
G
A
P
A
-------------
7
PsiBlast_PDB
78.56
28%
-23
- C8 -
-
4D9F
2
DCYD_SALTY
A:
[51-334]
-------------------------------------------
I
K
R
D
D
V
T
P
I
-
A
-
M
G
--
G
N
-
K
L
R
K
L
E
F
L
V
A
D
A
L
R
E
G
A
D
T
L
I
T
A
--
G
A
I
Q
S
N
H
V
R
Q
T
A
A
V
A
A
K
L
G
L
H
C
V
A
L
L
---
E
N
--
P
I
---
G
------
T
T
A
E
N
------
Y
L
T
N
G
N
R
L
L
-
L
D
L
-
F
N
T
Q
I
E
--
M
C
D
A
L
---
T
D
P
----------
D
---
A
Q
L
-
Q
T
L
A
T
R
I
E
A
Q
G
-
F
R
P
Y
V
I
P
V
G
G
-
S
-
S
A
-----
L
G
----
A
M
G
Y
V
E
S
A
L
E
I
A
Q
Q
C
E
E
V
V
G
------------
L
S
--
S
V
V
V
A
S
G
S
A
G
T
H
A
G
L
A
V
G
L
E
H
L
MPD
V
E
L
I
G
V
T
V
S
R
S
V
A
---
E
---
Q
K
P
--------------
K
-
V
I
-
A
-
L
-
Q
-
Q
A
I
----
A
G
Q
L
----
A
-------
L
-------
T
A
-------------
T
---------------
A
D
I
H
L
---
W
D
D
------
Y
F
A
P
G
Y
G
V
P
N
D
A
G
M
E
A
V
K
L
L
A
S
L
E
G
V
L
L
D
P
V
Y
T
G
K
A
M
A
G
L
I
D
G
I
S
Q
K
R
F
N
D
D
G
P
I
L
F
I
H
T
G
G
A
P
A
-------------
3
PsiBlast_PDB
77.13
28%
-24
- C8 -
-
4D96
2
DCYD_SALTY
A:
[51-334]
-------------------------------------------
I
K
R
D
D
V
T
P
I
-
A
-
M
G
--
G
N
-
K
L
R
K
L
E
F
L
V
A
D
A
L
R
E
G
A
D
T
L
I
T
A
--
G
A
I
Q
S
N
H
V
R
Q
T
A
A
V
A
A
K
L
G
L
H
C
V
A
L
L
---
E
N
--
P
I
---
G
------
T
T
A
E
N
------
Y
L
T
N
G
N
R
L
L
-
L
D
L
-
F
N
T
Q
I
E
--
M
C
D
A
L
---
T
D
P
----------
D
---
A
Q
L
-
Q
T
L
A
T
R
I
E
A
Q
G
-
F
R
P
Y
V
I
P
V
G
G
-
S
-
S
A
-----
L
G
----
A
M
G
Y
V
E
S
A
L
E
I
A
Q
Q
C
E
E
V
V
G
------------
L
S
--
S
V
V
V
A
S
G
S
A
G
T
H
A
G
L
A
V
G
L
E
H
LMPD
V
E
L
I
G
V
T
V
S
R
S
V
A
---
E
---
Q
K
P
--------------
K
-
V
I
-
A
-
L
-
Q
-
Q
A
I
----
A
G
Q
L
----
A
-------
L
-------
T
A
-------------
T
---------------
A
D
I
H
L
---
W
D
D
------
Y
F
A
P
G
Y
G
V
P
N
D
A
G
M
E
A
V
K
L
L
A
S
L
E
G
V
L
L
D
P
V
Y
T
G
K
A
M
A
G
L
I
D
G
I
S
Q
K
R
F
N
D
D
G
P
I
L
F
I
H
T
G
G
A
P
A
-------------
5
PsiBlast_PDB
76.38
28%
-25
- C8 -
-
4D9C
2
DCYD_SALTY
A:
[51-334]
-------------------------------------------
I
K
R
D
D
V
T
P
I
-
A
-
M
G
--
G
N
-
K
L
R
K
L
E
F
L
V
A
D
A
L
R
E
G
A
D
T
L
I
T
A
--
G
A
I
Q
S
N
H
V
R
Q
T
A
A
V
A
A
K
L
G
L
H
C
V
A
L
L
---
E
N
--
P
I
---
G
------
T
T
A
E
N
------
Y
L
T
N
G
N
R
L
L
-
L
D
L
-
F
N
T
Q
I
E
--
M
C
D
A
L
---
T
D
P
----------
D
---
A
Q
L
-
Q
T
L
A
T
R
I
E
A
Q
G
-
F
R
P
Y
V
I
P
V
G
G
-
S
-
S
A
-----
L
G
----
A
M
G
Y
V
E
S
A
L
E
I
A
Q
Q
C
E
E
V
V
G
------------
L
S
--
S
V
V
V
A
S
G
S
A
G
T
H
A
G
L
A
V
G
L
E
H
LMPD
V
E
L
I
G
V
T
V
S
R
S
V
A
---
E
---
Q
K
P
--------------
K
-
V
I
-
A
-
L
-
Q
-
Q
A
I
----
A
G
Q
L
----
A
-------
L
-------
T
A
-------------
T
---------------
A
D
I
H
L
---
W
D
D
------
Y
F
A
P
G
Y
G
V
P
N
D
A
G
M
E
A
V
K
L
L
A
S
L
E
G
V
L
L
D
P
V
Y
T
G
K
A
M
A
G
L
I
D
G
I
S
Q
K
R
F
N
D
D
G
P
I
L
F
I
H
T
G
G
A
P
A
-------------
17
PsiBlast_PDB
74.55
23%
4
- C8 -
-
1TZM
3
1A1D_PSEUD
A:
[19-327]
------------------
Q
P
L
A
R
-
L
S
K
H
L
G
---
G
--
K
--
V
H
L
Y
A
K
R
E
D
C
N
S
G
L
A
-
F
G
--
G
N
-
K
T
R
K
L
E
Y
L
I
P
E
A
L
A
Q
G
C
D
T
L
V
S
I
--
G
G
I
Q
S
N
Q
T
R
Q
V
A
A
V
A
A
H
L
G
M
K
C
V
L
V
Q
E
------------------
N
W
V
N
Y
------
S
D
A
V
Y
D
R
V
G
N
I
Q
M
S
R
I
L
G
A
D
--
V
--
R
L
V
PD
R
S
W
----------
E
---
D
A
L
-
E
S
V
----
R
A
A
G
-
G
K
P
Y
A
I
P
A
G
C
-
S
-
D
H
PLGG-
L
G
----
F
V
G
-----------
F
A
E
E
V
R
A
Q
E
A
E
L
GF---
K
F
D
Y
-
V
V
V
C
S
V
-
T
G
S
T
Q
A
G
M
-----------------
V
V
G
F
A
A
---
D
GRA
D
R
V
--
I
G
V
-----
D
A
S
A
K
-
P
A
-
Q
-
T
-
R
-
E
Q
I
----
T
-------
R
-------
I
-------
A
R
Q
T
A
E
K
V
GLE
R
D
I
M
R
---------------
A
D
V
V
L
---
D
E
R
------
F
A
G
P
E
Y
G
L
P
N
E
G
T
L
E
A
I
R
L
C
A
R
T
E
G
M
L
T
D
P
V
Y
E
G
K
S
M
H
G
M
I
E
M
V
R
N
G
E
F
P
E
G
S
R
V
L
Y
A
H
L
G
G
V
P
A
-------------
57
HHSearch
74.10
23%
11
- C8 -
-
4D9B
4
DCYD_SALTY
A:
[26-341]
-------------
L
E
F
I
G
A
P
T
P
L
-
E
Y
L
P
R
L
S
D
Y
L
--
G
--
R
E
I
Y
I
K
R
D
D
V
----
T
-
P
I
AM
G
G
N
K
L
R
K
L
E
F
L
V
A
D
A
L
R
E
G
A
D
T
L
I
T
A
--
G
A
I
Q
S
N
H
V
R
Q
T
A
A
V
A
A
K
L
G
L
H
C
V
A
L
L
E
N
-
P
I
GT
T
A
---
E
N-----
Y
L
T
N
G
------
N
R
L
L
L
D
L
F
N
-
T
Q
I
E
M
C
D
A
L
T
--
D
--
P
D
---
A
Q
L
----------
Q
---
T
L
A
-
T
R
I
----
E
A
Q
G
-
F
R
P
Y
V
I
P
V
G
G
-
S
-
S
A
-----
L
G
----
A
M
G
-----------
Y
V
E
S
A
L
E
I
A
Q
Q
C
EEVV-
G
L
S
--
S
V
V
V
A
S
G
S
A
G
T
H
A
G
L
-----------------
A
V
G
L
E
H
LMP
D
---
V
E
L
--
I
G
V
-----
T
V
-
S
R
-
S
V
A
E
-
Q
-
K
-
P
K
V
I
A
L
Q
Q
-------
A
-------
I
A
G
Q
----
L
A
LTA----------
T
---------------
A
D
I
H
L
---
W
D
D
------
Y
F
A
P
G
Y
G
V
P
N
D
A
G
M
E
A
V
K
L
L
A
S
L
E
G
V
L
L
D
P
V
Y
T
G
K
A
M
A
G
L
I
D
G
I
S
Q
K
R
F
N
D
D
G
P
I
L
F
I
H
T
G
G
A
P
A
L
F
A
Y
H
P
H
------
16
PsiBlast_PDB
73.93
23%
8
- C8 -
-
1TZK
2
1A1D_PSEUD
A:
[19-327]
------------------
Q
P
L
A
R
-
L
S
K
H
L
G
---
G
--
K
--
V
H
L
Y
A
K
R
E
D
C
N
S
G
L
A
-
F
G
--
G
N
-
K
T
R
K
L
E
Y
L
I
P
E
A
L
A
Q
G
C
D
T
L
V
S
I
--
G
G
I
Q
S
N
Q
T
R
Q
V
A
A
V
A
A
H
L
G
M
K
C
V
L
V
Q
E
------------------
N
W
V
N
Y
------
S
D
A
V
Y
D
R
V
G
N
I
Q
M
S
R
I
L
G
A
D
--
V
--
R
L
VPD
R
S
W
----------
E
---
D
A
L
-
E
S
V
----
R
A
A
G
-
G
K
P
Y
A
I
P
A
G
C
-
S
-
D
H
PLGG-
L
G
----
F
V
G
-----------
F
A
E
E
V
R
A
Q
E
A
E
L
GF---
K
F
D
Y
-
V
V
V
C
S
V
-
T
G
S
T
Q
A
G
M
-----------------
V
V
G
F
A
A
---
D
GRA
D
R
V
--
I
G
V
-----
D
A
S
A
K
-
P
A
-
Q
-
T
-
R
-
E
Q
I
----
T
-------
R
-------
I
-------
A
R
Q
T
A
E
K
V
GLE
R
D
I
M
R
---------------
A
D
V
V
L
---
D
E
R
------
F
A
G
P
E
Y
G
L
P
N
E
G
T
L
E
A
I
R
L
C
A
R
T
E
G
M
L
T
D
P
V
Y
E
G
K
S
M
H
G
M
I
E
M
V
R
N
G
E
F
P
E
G
S
R
V
L
Y
A
H
L
G
G
V
P
A
-------------
13
PsiBlast_PDB
73.90
23%
5
- C8 -
-
1TYZ
1
1A1D_PSEUD
A:
[19-327]
------------------
Q
P
L
A
R
-
L
S
K
H
L
G
---
G
--
K
--
V
H
L
Y
A
K
R
E
D
C
N
S
G
L
A
-
F
G
--
G
N
-
K
T
R
K
L
E
Y
L
I
P
E
A
L
A
Q
G
C
D
T
L
V
S
I
--
G
G
I
Q
S
N
Q
T
R
Q
V
A
A
V
A
A
H
L
G
M
K
C
V
L
V
Q
E
------------------
N
W
V
N
Y
------
S
D
A
V
Y
D
R
V
G
N
I
Q
M
S
R
I
L
G
A
D
--
V
--
R
L
V
P
D
R
S
W
----------
E
---
D
A
L
-
E
S
V
----
R
A
A
G
-
G
K
P
Y
A
I
P
A
G
C
-
S
-
D
H
PLGG-
L
G
----
F
V
G
-----------
F
A
E
E
V
R
A
Q
E
A
E
L
GF---
K
F
D
Y
-
V
V
V
C
S
V
-
T
G
S
T
Q
A
G
M
-----------------
V
V
G
F
A
A
---
D
GRA
D
R
V
--
I
G
V
-----
D
A
S
A
K
-
P
A
-
Q
-
T
-
R
-
E
Q
I
----
T
-------
R
-------
I
-------
A
R
Q
T
A
E
K
V
GLE
R
D
I
M
R
---------------
A
D
V
V
L
---
D
E
R
------
F
A
G
P
E
Y
G
L
P
N
E
G
T
L
E
A
I
R
L
C
A
R
T
E
G
M
L
T
D
P
V
Y
E
G
K
S
M
H
G
M
I
E
M
V
R
N
G
E
F
P
E
G
S
R
V
L
Y
A
H
L
G
G
V
P
A
-------------
12
PsiBlast_PDB
73.35
23%
6
- C8 -
-
1RQX
2
1A1D_PSEUD
A:
[19-327]
------------------
Q
P
L
A
R
-
L
S
K
H
L
G
---
G
--
K
--
V
H
L
Y
A
K
R
E
D
C
N
S
G
L
A
-
F
G
--
G
N
-
K
T
R
K
L
E
Y
L
I
P
E
A
L
A
Q
G
C
D
T
L
V
S
I
--
G
G
I
Q
S
N
Q
T
R
Q
V
A
A
V
A
A
H
L
G
M
K
C
V
L
V
Q
E
------------------
N
W
V
N
Y
------
S
D
A
V
Y
D
R
V
G
N
I
Q
M
S
R
I
L
G
A
D
--
V
--
R
L
V
P
D
R
S
W
----------
E
---
D
A
L
-
E
S
V
----
R
A
A
G
-
G
K
P
Y
A
I
P
A
G
C
-
S
-
D
H
PLGG-
L
G
----
F
V
G
-----------
F
A
E
E
V
R
A
Q
E
A
E
L
GF---
K
F
D
Y
-
V
V
V
C
S
V
-
T
G
S
T
Q
A
G
M
-----------------
V
V
G
F
A
A
---
D
GRA
D
R
V
--
I
G
V
-----
D
A
S
A
K
-
P
A
-
Q
-
T
-
R
-
E
Q
I
----
T
-------
R
-------
I
-------
A
R
Q
T
A
E
K
V
GLE
R
D
I
M
R
---------------
A
D
V
V
L
---
D
E
R
------
F
A
G
P
E
Y
G
L
P
N
E
G
T
L
E
A
I
R
L
C
A
R
T
E
G
M
L
T
D
P
V
Y
E
G
K
S
M
H
G
M
I
E
M
V
R
N
G
E
F
P
E
G
S
R
V
L
Y
A
H
L
G
G
V
P
A
-------------
14
PsiBlast_PDB
73.10
23%
8
- C8 -
-
1TZ2
2
1A1D_PSEUD
A:
[19-327]
------------------
Q
P
L
A
R
-
L
S
K
H
L
G
---
G
--
K
--
V
H
L
Y
A
K
R
E
D
C
N
S
G
L
A
-
F
G
--
G
N
-
K
T
R
K
L
E
Y
L
I
P
E
A
L
A
Q
G
C
D
T
L
V
S
I
--
G
G
I
Q
S
N
Q
T
R
Q
V
A
A
V
A
A
H
L
G
M
K
C
V
L
V
Q
E
------------------
N
W
V
N
Y
------
S
D
A
V
Y
D
R
V
G
N
I
Q
M
S
R
I
L
G
A
D
--
V
--
R
L
VPD
R
S
W
----------
E
---
D
A
L
-
E
S
V
----
R
A
A
G
-
G
K
P
Y
A
I
P
A
G
C
-
S
-
D
H
PLGG-
L
G
----
F
V
G
-----------
F
A
E
E
V
R
A
Q
E
A
E
L
GF---
K
F
D
Y
-
V
V
V
C
S
V
-
T
G
S
T
Q
A
G
M
-----------------
V
V
G
F
A
A
---
D
GRA
D
R
V
--
I
G
V
-----
D
A
S
A
K
-
P
A
-
Q
-
T
-
R
-
E
Q
I
----
T
-------
R
-------
I
-------
A
R
Q
T
A
E
K
V
GLE
R
D
I
M
R
---------------
A
D
V
V
L
---
D
E
R
------
F
A
G
P
E
Y
G
L
P
N
E
G
T
L
E
A
I
R
L
C
A
R
T
E
G
M
L
T
D
P
V
Y
E
G
K
S
M
H
G
M
I
E
M
V
R
N
G
E
F
P
E
G
S
R
V
L
Y
A
H
L
G
G
V
P
A
-------------
15
PsiBlast_PDB
72.85
23%
8
- C8 -
-
1TZJ
2
1A1D_PSEUD
A:
[19-327]
------------------
Q
P
L
A
R
-
L
S
K
H
L
G
---
G
--
K
--
V
H
L
Y
A
K
R
E
D
C
N
S
G
L
A
-
F
G
--
G
N
-
K
T
R
K
L
E
Y
L
I
P
E
A
L
A
Q
G
C
D
T
L
V
S
I
--
G
G
I
Q
S
N
Q
T
R
Q
V
A
A
V
A
A
H
L
G
M
K
C
V
L
V
Q
E
------------------
N
W
V
N
Y
------
S
D
A
V
Y
D
R
V
G
N
I
Q
M
S
R
I
L
G
A
D
--
V
--
R
L
VPD
R
S
W
----------
E
---
D
A
L
-
E
S
V
----
R
A
A
G
-
G
K
P
Y
A
I
P
A
G
C
-
S
-
D
H
PLGG-
L
G
----
F
V
G
-----------
F
A
E
E
V
R
A
Q
E
A
E
L
GF---
K
F
D
Y
-
V
V
V
C
S
V
-
T
G
S
T
Q
A
G
M
-----------------
V
V
G
F
A
A
---
D
GRA
D
R
V
--
I
G
V
-----
D
A
S
A
K
-
P
A
-
Q
-
T
-
R
-
E
Q
I
----
T
-------
R
-------
I
-------
A
R
Q
T
A
E
K
V
GLE
R
D
I
M
R
---------------
A
D
V
V
L
---
D
E
R
------
F
A
G
P
E
Y
G
L
P
N
E
G
T
L
E
A
I
R
L
C
A
R
T
E
G
M
L
T
D
P
V
Y
E
G
K
S
M
H
G
M
I
E
M
V
R
N
G
E
F
P
E
G
S
R
V
L
Y
A
H
L
G
G
V
P
A
-------------
68
HHSearch
69.21
21%
-0
- C8 -
-
1F2D
1
1A1D_CYBSA
A:
[10-335]
--------------
P
L
T
F
G
P
S
P
I
-
S
N
L
N
R
L
S
Q
H
L
--
G
SK
V
N
V
Y
A
K
R
E
D
C
N
S
G
-
L
A
F
G
--
G
N
-
K
L
R
K
L
E
Y
I
V
P
D
I
V
E
G
D
Y
T
H
L
V
S
I
G
G
R
Q
S
--
N
Q
T
R
M
V
A
A
L
A
A
K
L
G
K
K
C
V
L
I
Q
E
D
-
W
V
--
P
I
---
P
EAEKDV
Y
N
R
V
G
------
N
I
E
L
S
R
I
M
G
-
A
D
V
R
V
I
E
D
G
F
-----
D
I
---
G
M
R
----------
K
S
F
A
N
A
L
-
Q
E
L
----
E
D
A
G
-
H
K
P
Y
P
I
P
A
G
C
S
E
-
H
K
-----
Y
G
----
G
L
G
-----------
F
V
G
F
A
D
E
V
I
N
Q
E
V
E
L
GI
K
F
D
--
K
I
V
V
C
C
V
T
G
S
T
T
A
G
I
-----------------
L
A
G
M
A
Q
Y
GR
Q
---
D
D
V
--
I
A
I
-----
D
A
-
S
F
-
T
S
-
E
-
K
T
K
-
E
Q
T
----
L
R
I
A
N
N
T
A
K
-------
L
-------
I
G
VEHE---------
F
---------------
K
D
F
T
L
---
D
T
R
------
F
A
Y
P
C
Y
G
V
P
N
E
G
T
I
E
A
I
R
T
C
A
E
Q
E
G
V
L
T
D
P
V
Y
E
G
K
S
M
Q
G
L
I
A
L
I
K
E
D
Y
F
K
P
G
A
N
V
L
Y
V
H
L
G
G
A
P
A
L
S
A
Y
S
S
F
------
60
HHSearch
67.25
22%
21
- C8 -
-
1J0C
1
1A1D_CYBSA
D:
[10-335]
--------------
P
L
T
F
G
P
S
P
I
-
S
N
L
N
R
L
SQH
L
GS
K
--
V
N
V
Y
A
K
R
E
D
C
N
S
G
L
A
-
F
G
--
G
N
-
T
L
R
K
L
E
Y
I
V
P
D
I
V
E
G
D
Y
T
H
L
V
S
I
--
G
G
R
Q
S
N
Q
T
R
M
V
A
A
L
A
A
K
L
G
K
K
C
V
L
I
Q
E
D
-
W
V
--
P
I
---
P
EAEKDV
Y
N
R
V
G
------
N
I
E
L
S
R
I
M
G
-
A
D
V
R
V
I
E
D
G
F
-----
D
I
---
G
M
R
KSF-------
A
---
N
A
L
-
Q
E
L
----
E
D
A
G
-
H
K
P
Y
P
I
P
A
G
C
-
S
E
H
K
-----
Y
G
----
G
L
G
-----------
F
V
G
F
A
D
E
V
I
N
Q
EVELGI
K
F
D
--
K
I
V
V
C
C
V
T
G
S
T
T
A
G
I
-----------------
L
A
G
M
A
Q
YGR
Q
---
D
D
V
--
I
A
I
-----
D
A
-
S
F
-
T
S
-
E
-
K
-
T
K
E
Q
T
----
L
-------
R
IANNTAK
L
-------
I
G
VEHE---------
F
---------------
K
D
F
T
L
---
D
T
R
------
F
A
Y
P
C
Y
G
V
P
N
E
G
T
I
E
A
I
R
T
C
A
E
Q
E
G
V
L
T
D
P
V
Y
E
G
K
S
M
Q
G
L
I
A
L
I
K
E
D
Y
F
K
P
G
A
N
V
L
Y
V
H
L
G
G
A
P
A
L
S
A
Y
S
S
F
------
76
Fugue
66.84
22%
21
- C8 -
-
1F2D
1
1A1D_CYBSA
A:
[1-341]
AGVAK
F
A
K
Y
P
LT
F
G
P
S
P
I
S
N
L
N
R
-
L
S
Q
H
L
G
---
S
--
K
--
V
N
V
Y
A
K
R
E
D
C
N
S
G
-
L
A
F
G
--
G
N
-
K
L
R
K
L
E
Y
I
V
P
D
I
V
E
G
D
Y
T
H
L
V
S
I
--
G
G
R
Q
S
N
Q
T
R
M
V
A
A
L
A
A
K
L
G
K
K
C
V
L
I
Q
E
D
-
W
V
--
P
I
---
P
------
E
A
E
K
D
VYNRVG
N
I
E
L
S
R
I
M
G
-
A
D
V
R
V
I
E
D
G
F
D
I
G
--
M
R
---
K
S
F
----------
A
---
N
A
L
-
Q
E
L
----
E
D
A
G
-
H
K
P
Y
P
I
P
A
G
C
-
S
-
E
H
KY
G
G
L
G
F
----
V
G
F
-----------
A
D
E
V
I
N
Q
E
V
E
L
GI----
K
F
D
--
K
I
V
V
C
C
V
T
G
S
T
T
A
G
I
-----------------
L
A
G
M
A
Q
Y
GR
Q
---
D
D
V
--
I
A
I
D
ASFT
S
E
-
K
T
-
K
E
-
Q
-
T
-
L
-
R
I
A
----
N
-------
N
-------
T
-------
A
K
-------------
L
I
GVEHEF--------
K
D
F
T
L
---
D
T
R
------
F
A
Y
P
C
Y
G
V
P
N
E
G
T
I
E
A
I
R
T
C
A
E
Q
E
G
V
L
T
D
P
V
Y
E
G
K
S
M
Q
G
L
I
A
L
I
K
E
D
Y
F
K
P
G
A
N
V
L
Y
V
H
L
G
G
A
P
A
L
S
A
Y
S
S
F
F
PTKTA
64
HHSearch
66.43
21%
6
- C8 -
-
1TZJ
2
1A1D_PSEUD
A:
[9-332]
-------------
Y
P
L
T
F
G
P
T
P
I
-
Q
P
L
A
R
L
S
K
H
L
--
G
GK
V
H
L
Y
A
K
R
E
D
C
N
S
G
L
A
-
F
G
--
G
N
-
K
T
R
K
L
E
Y
L
I
P
E
A
L
A
Q
G
C
D
T
L
V
S
I
G
G
I
Q
S
--
N
Q
T
R
Q
V
A
A
V
A
A
H
L
G
M
K
C
V
L
V
Q
E
N
-
W
V
--
N
Y
SDA
V
------
Y
D
R
V
G
------
N
I
Q
M
S
R
I
L
G
-
A
D
V
R
L
V
P
D
---------------R
S
--------
W
---
E
D
A
-
L
E
S
----
V
R
A
A
G
G
K
P
Y
A
I
P
A
G
C
-
S
D
H
P
-----
L
G
----
G
L
G
-----------
F
V
G
F
A
E
E
V
R
A
Q
E
A
E
L
GF
K
F
D
--
Y
V
V
V
C
S
V
T
G
S
T
Q
A
G
M
-----------------
V
V
G
F
A
A
D
GR
A
---
D
R
V
--
I
G
V
-----
D
A
-
S
A
-
K
P
-
A
Q
T
-
R
-
E
Q
I
----
T
-------
R
-------
I
A
R
Q
T
A
E
K
V
G
LE
R
D
I
M
-------
R
---------------
A
D
V
V
L
---
D
E
R
------
F
A
G
P
E
Y
G
L
P
N
E
G
T
L
E
A
I
R
L
C
A
R
T
E
G
M
L
T
D
P
V
Y
E
G
K
S
M
H
G
M
I
E
M
V
R
N
G
E
F
P
E
G
S
R
V
L
Y
A
H
L
G
G
V
P
A
L
N
G
Y
S
--------
63
HHSearch
66.17
21%
3
- C8 -
-
1TYZ
1
1A1D_PSEUD
C:
[9-332]
-------------
Y
P
L
T
F
G
P
T
P
I
-
Q
P
L
A
R
L
S
K
H
L
--
G
GK
V
H
L
Y
A
K
R
E
D
C
N
S
G
L
A
-
F
G
--
G
N
-
K
T
R
K
L
E
Y
L
I
P
E
A
L
A
Q
G
C
D
T
L
V
S
I
G
G
I
Q
S
--
N
Q
T
R
Q
V
A
A
V
A
A
H
L
G
M
K
C
V
L
V
Q
E
N
-
W
V
--
N
Y
SDA
V
------
Y
D
R
V
G
------
N
I
Q
M
S
R
I
L
G
-
A
D
V
R
L
V
P
D
G
F
-----
D
I
---
G
F
R
R
S
--------
W
---
E
D
A
-
L
E
S
----
V
R
A
A
G
G
K
P
Y
A
I
P
A
G
C
-
S
D
H
P
-----
L
G
----
G
L
G
-----------
F
V
G
F
A
E
E
V
R
A
Q
E
A
E
L
GF
K
F
D
--
Y
V
V
V
C
S
V
T
G
S
T
Q
A
G
M
-----------------
V
V
G
F
A
A
D
GR
A
---
D
R
V
--
I
G
V
-----
D
A
-
S
A
-
K
P
-
A
Q
T
-
R
-
E
Q
I
----
T
-------
R
-------
I
A
R
Q
T
A
E
K
V
G
LERDIM-------
R
---------------
A
D
V
V
L
---
D
E
R
------
F
A
G
P
E
Y
G
L
P
N
E
G
T
L
E
A
I
R
L
C
A
R
T
E
G
M
L
T
D
P
V
Y
E
G
K
S
M
H
G
M
I
E
M
V
R
N
G
E
F
P
E
G
S
R
V
L
Y
A
H
L
G
G
V
P
A
L
N
G
Y
S
--------
9
PsiBlast_PDB
64.20
23%
2
- C8 -
-
1J0E
2
1A1D_CYBSA
A:
[49-328]
-----------------------------------------------------------
G
N
-
K
L
R
K
L
E
Y
I
V
P
D
I
V
E
G
D
Y
T
H
L
V
S
I
--
G
G
R
Q
S
N
Q
T
R
M
V
A
A
L
A
A
K
L
G
K
K
C
V
L
I
--
Q
-
E
D
--
W
V
---
P
------
I
P
E
A
E
------
K
D
V
Y
N
R
V
G
N
-
I
E
L
S
R
I
M
G
A
D
--
V
--
R
V
---
I
E
D
GFDIGMR
K
S
F
A
---
N
A
L
-
Q
E
L
----
E
D
A
G
-
H
K
P
Y
P
I
P
A
G
C
-
S
-
E
H
KYGG-
L
G
----
F
V
G
-----------
F
A
D
E
V
I
N
Q
E
V
E
L
GI---
K
F
D
K
I
V
V
C
C
V
--
T
G
S
T
T
A
G
I
-----------------
L
A
G
M
A
Q
---
Y
---
G
R
Q
--
D
D
V
-----
I
A
-
I
D
-
A
S
-
F
-
T
-
S
-
E
K
T
----
K
-------
E
-------
Q
-------
T
L
-------------
R
I
A
N
N
T
A
K
L
I
GVEHEF
K
D
F
T
L
---
D
T
R
------
F
A
Y
P
C
Y
G
V
P
N
E
G
T
I
E
A
I
R
T
C
A
E
Q
E
G
V
L
T
D
P
V
F
E
G
K
S
M
Q
G
L
I
A
L
I
K
E
D
Y
F
K
P
G
A
N
V
L
Y
V
H
L
G
G
A
P
A
-------------