@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VU51: (2017-12-17 )
MATIHVDGKSYEVNGSENLLQACLSLGIDIPYFCWHPSLGSVGSCRQCAVTQYANPEDTRGRLVMSCMTPASDNTYISIEDKEAVDFRESIVEFLMTNHPHDCPVCEEGGHCHLQDMTVMTGHDRRRYRFTKRTHYNQELGSFIAHEMNRCIACYRCVRYYKDYAGGTDFGVYANASRVYFGRPESGTLESEFSGNLTEVCPTGVFTDKTHSERYNRKWDMQYAPSVCHGCSSGCNISPGERYGEIRRVENRFNGSVNQYFLCDKGRFGTGYVNRADRPRQPQFRNGETVATVSVDQALDQTIAKLEGKKVLGIGSPRASLESNYALRELVGQANYSTGVAQKEQSLVELAASIMQTEGIYNPNMREIESYDAVLILGEDLTQTAPRMALSVRQAAKNKAREMAAKTRTPDWLAEPVQRIGQEAKSPIYILAATQTRLADVATGEVVASPNDIARLGFAVAAAVKGETVNGLDEDAKAFAQTIADTLKAANKPLIIAGTSLQDASIMEAAAELTQNLGSKAGLSLVVPEVNSMGLALFGGLSLEQAFAQDYDTLVIVENDLFRRLPAAQVKAALDKAETVIVLDHSETETVKQADIVLSAASFAEGDGTVVSQEGRAQRFYQVYDPSYYKPEYAIKESWRWLHAIETGLKGKPIDWTVLDDVIETIVKNVPVLEAIQDVAPDAGYRVHGLKIAREPRRYSGRTAMRAPLSVHEPKQPTDPDSALTFSMEGYVGPQKASSLVPFAWAPGWNSPQSWNKYQDEVGGHLKGGDSGVRLFDRLAKRPARSYVAPTAVVANPESFRLVPMHHIFGSGEFTIKTPAMETRIPEAVFAVGEQDATRLNLQEGQRITVKAGETTVSLPVQVIEYLPTGYIGYPVGLAPTVSLAEPVSVALGV
Atome Classification :
(20 SA)
------------.........10........20.....-...30........40.........50.--.......---60.....-----------...70........80.-.......90.......---.100.......110.......120.......-----------130....-...140.......150-------------.........160.......170.------......180.-----------------------......190.......--200.......210.......-------220--------.......-.230--.......-240-----------------------------------------..-----------------------------..--..---------.250------.------....-..-------.260-.......270...------.-----..-.280.....--------------------------------------..290.......300.-----.....----...310-....-----.----....320...-.---.----.----.---330---.----.--......---340--------------.......350...-.-...--360.--....-....-370.....---------------..380.....-.---------.--390------.----.---...----..---.400.......410.......420.--------......430..---------------.....440----.-..--------......450---------.......460......------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------470---..-----.....480.......490---.------.-------------....--...500-.-.----.----....510......----.520.-----------..--------..------------..-----------530----..---..-.----------------.-----------------------------------------------.-----------------------------------------------.---------540--------------------------------.------------------------------------.------------------------.--------------------------.--------------------------.-----------------.----.------------.------------.---550.....-.-.560------.......----570----------------------------.------------------------------...-.----..-.-.580.......-590........600........610-.---.-.---.--.--...620.......630.......640.......650--------------.--------------.---.-----------.-----.------.--------------------.660..----------------..-----------------------------------...670-------.--.-----....-.---680.......690-.....--------..--.-----------.--------------------------------700-------..-.-------------...--------..---.710.....-----.-----.-----720...-.-...------------.730----..---------....--.740.--...-----...750.......760......---.770...-....780...---------------...-.790.......800----------------------------------------------....--.--..810.....-.-.820..-.---...------.830.......840.......850......--.860.--......870------------------.......880.--.....--...890..-------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------
M
A
T
I
H
VDG
K
S
Y
E
VNG
S
E
N
L
L
Q
A
C
L
SL-GIDIP
Y
F
CWHPSLG-SVG
S
C
R
Q
C
A
VTQ--YANPEDT---R
G
R
L
V
M
S
-----------
C
MTPASDN
T
Y
I
S
IED
K
-
E
A
V
D
F
R
E
S
I
V
E
F
L
MTN---HPHDCPVCEEGGH
C
H
L
Q
D
M
T
VMTGHDR
R
R
Y
R
-----------
F
TKRTH
Y
-
N
Q
E
L
G
S
F
I
A
H
E
M
N
R
---------------
C
I
A
C
Y
R
C
V
R
Y
Y
K
D
YAGGTD
F
G
V
Y
------ANA
S
R
V
Y
FGR-----------------------PESGTLESEFSGN
L
T
E--VCPTGVFTDKT
H
S
E
R
YNRKW-------DM---------QYA
P
S
V
C
-HGCS--SGCNIS
P
-
G
E
R
-----------------------------------------
Y
G
-----------------------------
E
I
--
R
R
---------
V
E
N
-------
R
------FNGS-V
N
-------
Q
Y
F
L
-CDKGRFGTGYVNR------A-----DR-PRQPQFRNG--------------------------------------
E
T
V
A
T
V
S
V
D
Q
A
L
D
--
Q
-----
T
I
A
K
L----EG
K
K
---
V
L
GI-----G----SPRASLES
N
Y
-
A
---
L
----
R
----
E
---
L
V----G----Q--ANYSTG---V
A
Q
--------------
K
E
Q
S
L
V
E
L
A
A
S
I
M
-
Q
-TEG--I--Y--NP
N
M
-
R
E
I
E-SY
D
A
V
L
I
L---------------GE
D
L
T
Q
T
A
P
R
-
M
---------
A
--
L
S
-------
V
----
R
---
Q
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----
K
N
---
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A
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M
A
AKTR
T
P
D
W
L
A
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P
V
Q
R
I
G
Q
E
--------AKS
P
I
Y
I
L
AAT---------------Q
T
R
L
A
D------V-AT--------G
E
V
VAS
P
N
D
---------
I
A
R
L
G
F
A
V
A
A
AVKGET------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NG
L
---
D
E
-----
D
A
K
A
F
A
Q
T
I
A
D
T
L
K
AA-----N------K-------------
P
L
I
I
--AGTSLQ-
D
-
A
----
S
----
I
M
E
A
A
A
E
L
T
Q
N
LG----SKAG
L
-----------
S
L
--------
V
V------------PE-----------VN-----SM---
G
L
-
A
----------------
L
-----------------------------------------------F-----------------------------------------------G---------G----------------------------------
L
------------------------------------
S
------------------------
L
--------------------------
E
--------------------------
Q
-----------------
A
----
F
------------A------------Q---DY
D
T
L
V
I
V-E-
N
D
L
F
------
R
RL
P
A
A
Q
----
V
------------------------------
K
------------------------------
A
A
L-D----KA-
E
-
T
V
I
V
L
DHSETE-T
V
-
K
QA
D
I
V
L
S
AA-SFAEGDG
T
V
-V-S---Q-E---G--R--A
Q
R
F
Y
QVYDPSYYKP
E
Y
A
I
K
E
S
W
R
W
L
H
A
I
E
TGLKGK--------------P--------------I---
D
-----------
W
-----
T
------
V
--------------------
L
D
D
V
I
E
----------------
T
I
-----------------------------------
V
KNV
P
V
-------
L
--
E
-----
A
I
Q
D
-V---APDAG
Y
R
V
H
G
L
---
K
I
ARE--------PR--R-----------Y--------------------------------S---------GR-T-------------AMR--------AP---LSVHEPKQP-----T-----D-----P-DS
A
L
-
T
-
F
S
M------------EGYV----GP---------QKAS--SLV
P
F
--
A
WA-----PGWNSPQ
S
W
N
K
Y
Q
D
EVGGHLKG---GD
S
G
V
R
L
-
F
D
R
L
A
KRP
A
R
---------------SYV-APT
A
V
VANPE
S
F
R
L
----------------------------------------------
V
P
M
H
--H--IFGSG
E
F
T
I
K-T-PAMETR-I---
P
E
A
------
V
F
AVGEQD
A
T
R
L
NLQEG
Q
R
I
T
V
KAG
E
T
T
V
S
--
L
P
V
Q
V
--
I
E
YLPTGYI------------------GYPVGLAP--T--VSLAE--
P
V
S
V
ALGV-------------------------------------------
22
HHSearch
100.00
22%
0
- C- -
-
4HEA
-
NQO3_THET8
D:
[1-772]
------------
M
V
R
V
K
V
N
D
R
I
V
E
V
P
P
G
T
S
V
M
D
A
V
F
H
A
-
G
Y
D
V
P
L
F
C
S
E
K
H
L
S
-
P
I
G
A
C
R
M
C
L
V
R
I
--
G
L
P
----IQW
Q
P
K
L
A
A
S
-----------
C
V
T
A
V
A
D
G
M
V
V
D
T
L
S
D
-
V
V
R
E
A
Q
A
G
M
V
E
F
T
L
L
N
---
H
P
L
D
C
P
T
C
D
K
G
G
A
C
E
L
Q
D
R
T
V
E
Y
G
L
Y
E
K
Y
--PLELPVYTRFE
F
T
R
R
H
V
D
K
H
H
P
L
S
P
F
V
I
L
D
R
E
R
---------------
C
I
H
C
K
R
C
V
R
Y
F
E
E
V
P
G
D
E
V
L
D
F
I
------
E
R
G
V
H
T
F
I
G
T
-----------------------
M
-
D
F
G
L
P
S
G
F
S
G
N
I
T
D
--
I
C
P
V
G
A
L
L
D
L
T
A
R
F
-
R
A
R
N
W
-------
E
M
---------
E
E
T
P
T
T
C
-
A
L
C
P
--
V
G
C
G
I
T
A
-
D
T
R
-----------------------------------------
S
G
-----------------------------
E
L
--
L
R
---------
I
R
A
-------
R
------
E
V
P
E
-
V
N
-------
E
I
W
I
-
C
D
A
G
R
F
G
H
E
W
-
A
D
------
Q
-----
N
R
-
L
K
T
P
L
V
R
K
E
--------------------------------------
G
R
L
V
E
A
T
W
E
E
A
F
L
A
L
K
-----
E
G
L
K
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----
A
R
G
E
---
E
V
G
L
Y
----
L
----
A
H
D
A
T
L
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G
L
-
L
---
A
----
S
----
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---
L
A
----
K
A
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K-
T
--
P
H
L
D
F
Q
---------------------
G
R
T
A
A
P
A
---------
S
L
--
F
--
P
--
P
A
S
L
-
E
D
L
L
-
Q
A
D
F
A
L
V
L
---------------
G
-
D
P
T
E
E
A
P
I
-
L
---------
H
--
L
R
-------
L
----
S
---
E
F
V
----
R
D
---
L
K
P
P
H
R
Y
-
N
H
G
T
P
F
A
D
L
Q
I
K
E
R
M
P
R
--------
R
T
D
K
M
A
L
F
A
P
Y
---------------
R
A
P
L
M
K
------
W
-
A
A
--------
I
H
E
V
H
R
P
G
E
---------
E
R
E
I
L
L
A
L
L
G
D
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
M
V
A
K
A
K
E
A
W
E
K
A
-----
K
------
N
-------------
P
V
L
I
--
L
G
A
G
V
L
-
Q
-
D
----
T
----
V
A
A
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--
R
A
R
L
L
A
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R
---
K
G
A
K
V
-----------
L
A
--------
M
T
------------
P
A
-----------
A
N
-----
A
R
---
G
L
-
E
----------------
A
-----------------------------------------------
M
-----------------------------------------------
G
---------
V
----------------------------------
L
------------------------------------
P
------------------------
G
--------------------------
A
--------------------------
K
G----------------
A
----
S
------------
W
------------
D
---
E
P
G
A
L
Y
A
Y
Y
G
-
F
V
----------
P
--------
P
------------------------------
E
------------------------------
E
A
L
-
K
----
G
K
-
R
-
F
V
V
M
H
L
S
H
L
H
P
-
L
A
E
R
Y
A
H
V
V
L
P
A
P
-
T
F
Y
E
K
R
G
H
L
-
V
-
N
---
L
-
E
---
G
--
R
--
V
L
P
L
S
P
A
P
I
E
N
-
G
----
E
A
E
G
A
L
Q
V
L
A
L
L
A
E
A
L
G
V
R
--------------
P
------------------
P
-----------
F
-----
R
------
L
--------------------
H
L
E
A
Q
K
----------------
A
L
-----------------------------------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
------------
R
K
V
P
----
E
A
---------
M
G
R
L
--
S
F
R
L
K
--
E
L
----------------------------------------
R
----------------------------
P
---
K
E
R
K
G
A
F
Y
L
----------------------------------------------
R
P
T
------
M
W
K
A
H
Q
A
V
G
-----
K
A
Q
E
--
A
---
A
R
A
------
E
L
W
A
H
P
E
T
A
R
A
E
A
L
P
E
G
A
Q
V
A
V
E
T
P
F
G
R
V
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--
A
R
V
V
H
--
R
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D
V
P
K
G
H
L
------------------
Y
L
S
A
L
G
P
A
--
A
--
G
L
R
V
E
-----------------------------------------------------
30
HHSearch
66.16
18%
0
- C2 -
-
2V45
4
NAPA_DESDA
A:
[6-704]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------
K
W
V
K
G
V
C
-
R
Y
C
G
--
T
G
C
G
V
L
V
-
G
V
K
-----------------------------------------
D
G
-----------------------------
K
A
--
V
A
---------
I
Q
G
-------
N
------
P
N
N
--
H
N
-------
A
G
L
L
-
C
L
K
G
S
L
L
I
P
V
L
N
S
------
K
-----
E
R
-
V
T
Q
P
L
V
R
R
H
KG------------------------------------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
-----
S
R
F
R
S
S
I
D
M
Y
G
P
N
---
S
V
A
W
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----
G
----
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G
Q
C
L
T
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---
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----
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----
K
---
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F
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GGF
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----
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--
N
N
V
D
G
N
---
P
------------------
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L
C
M
A
S
A
V
G
G
Y
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T
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--
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DE
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--
M
G
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Y
-
A
D
I
D
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Q
A
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F
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---------------
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A
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---
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--------------------------------
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---------------
R
T
N
T
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------
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-
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--------
M
H
V
A
F
R
P
G
T
---------
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
LDN
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPSD
F
E
G
Y
K
A
F
L
E
NYR--------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
V
A
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C
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-----
V
P
V
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Q
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G
A
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T
M
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--
W
C
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----
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Q
G
V
F
A
N
N
L
I
H
N
L
H
L
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QICR
P
G
A
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-----------
F
S
--------
L
T
------------
G
Q
-----------
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N
-----
A
C
---
G
G
-
V
R---------------
D
-----------------------------------------------
G
-----------------------------------------------
G
---------
A
----------------------------------
L
SHLLPAGRAIPN
A
K
H
R
A
E
M
E
K
L
W
GLPEGRIAPEPGY
H
------------------------
T
--------------------------
V
--------------------------
A
-----------------
L
----
F
E
A
L
---------
G
R
-----------
G
---
D
V
K
C
M
I
I
C
E
T
-
N
P
A
H
------
T
L
P
N
L
N
K
----
V
------------------------------
H
------------------------------
K
A
M
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S
----
H
P
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G
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---
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---
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--
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A
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----
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F
A
R
R
A
G
V
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--------------
P
QL------------
V
---
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-----------
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-----
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------
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--------------------
A
E
D
V
W
N
----------------
E
W
-----------------------------------
R
M
V
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K
G
TTYD---
F
--
W
-----
G
M
T
-----------
R
----
E
---
R
L
R
K
E
--------
S
--------------------------------------------------------------------------------------------
G
L
I
W
P
C
P
S
-----
E
-----
D
H----
P
-
G
T
S
L
-
R
-
Y
V
R
------------
G
Q
D
P
CVPA
D
H
---------
P
D
R
F
--
F
F
Y
G
K
--
P
---------------------------------
D
G
R
A
V
I
-
W
M
R
P
A
K
-----------------------
G
A
A
E
E
P
D
A
E
Y
P
L
Y
L
----------------------------------------------
T
S
M
R
--
V
ID
H
W
H
T
A
T
M
T
G
K
-
V
-
P
E
L
Q
K
A
-
N
---
P
I
A
------
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
E
--
L
P
A
R
V
--
S
D
V
C
R
P
G
L
I
------------------
A
V
P
F
F
D
P
K
KL
V
--
N
K
L
F
L
--
D
A
T
------------------------------------------------
31
HHSearch
65.08
18%
-0
- C2 -
-
2NAP
5
NAPA_DESDA
A:
[6-704]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------
K
W
V
K
G
V
C
-
R
Y
C
G
--
T
G
C
G
V
L
V
-
G
V
K
-----------------------------------------
D
G
-----------------------------
K
A
--
V
A
---------
I
Q
G
-------
N
------
P
N
N
--
H
N
-------
A
G
L
L
-
C
L
K
G
S
L
L
I
P
V
L
N
S
------
K
-----
E
R
-
V
T
Q
P
L
V
R
R
H
KG------------------------------------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
-----
S
R
F
R
S
S
I
D
M
Y
G
P
N
---
S
V
A
W
Y
----
G
----
S
G
Q
C
L
T
E
E
S
Y
-
V
---
A
----
N
----
K
---
I
F
K
GGF
G
----
T
--
N
N
V
D
G
N
---
P
------------------
R
L
C
M
A
S
A
V
G
G
Y
V
T
-
S
F
G
--
K
DE
P
--
M
G
T
Y
-
A
D
I
D
-
Q
A
T
C
F
F
I
I
---------------
G
S
N
T
S
E
A
H
P
V
-
L
---------
F
--
R
R
-------
I
----
A
---
R
R
K
----
Q
V
---
E
--------------------------------
P
G
V
K
I
I
V
A
D
P
R
---------------
R
T
N
T
S
R
------
I
-
A
D
--------
M
H
V
A
F
R
P
G
T
---------
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
LDN
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPSD
F
E
G
Y
K
A
F
L
E
NYR--------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
V
A
E
I
C
R
-----
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
S
-----
A
------
A
-------------
T
M
S
L
--
W
C
M
G
I
N
-
Q
-
R
----
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
QICR
P
G
A
T
S
-----------
F
S
--------
L
T
------------
G
Q
-----------
P
N
-----
A
C
---
G
G
-
V
R---------------
D
-----------------------------------------------
G
-----------------------------------------------
G
---------
A
----------------------------------
L
SHLLPAGRAIPN
A
K
H
R
A
E
M
E
K
L
W
GLPEGRIAPEPGY
H
------------------------
T
--------------------------
V
--------------------------
A
-----------------
L
----
F
E
A
L
---------
G
R
-----------
G
---
D
V
K
C
M
I
I
C
E
T
-
N
P
A
H
------
T
L
P
N
L
N
K
----
V
------------------------------
H
------------------------------
K
A
M
-
S
----
H
P
-
E
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
-
E
Y
A
D
L
V
L
P
P
A
-
F
W
C
E
R
D
G
V
Y
-
G
-
C
---
G
-
E
---
R
--
R
--
Y
S
L
T
E
K
A
V
D
P
P
-
G
----
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
D
--------------
P
QL------------
V
---
N
-----------
F
-----
R
------
N
--------------------
A
E
D
V
W
N
----------------
E
W
-----------------------------------
R
M
V
S
K
G
TTYD---
F
--
W
-----
G
M
T
-----------
R
----
E
---
R
L
R
K
E
--------
S
--------------------------------------------------------------------------------------------
G
L
I
W
P
C
P
S
-----
E
-----
D
H----
P
-
G
T
S
L
-
R
-
Y
V
R
------------
G
Q
D
P
CVPA
D
H
---------
P
D
R
F
--
F
F
Y
G
K
--
P
---------------------------------
D
G
R
A
V
I
-
W
M
R
P
A
K
-----------------------
G
A
A
E
E
P
D
A
E
Y
P
L
Y
L
----------------------------------------------
T
S
M
R
--
V
ID
H
W
H
T
A
T
M
T
G
K
-
V
-
P
E
L
Q
K
A
-
N
---
P
I
A
------
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
E
--
L
P
A
R
V
--
S
D
V
C
R
P
G
L
I
------------------
A
V
P
F
F
D
P
K
KL
V
--
N
K
L
F
L
--
D
A
T
------------------------------------------------
34
HHSearch
59.47
18%
17
- C2 -
-
3ML1
4
NAPA_CUPNH
A:
[6-780]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
E
V
T
-------
K
L
---------
K
W
S
K
A
P
C
-
R
F
C
G
--
T
G
C
G
V
T
V
-
A
V
K
-----------------------------------------
D
N
-----------------------------
K
V
--
V
A
---------
T
Q
G
-------
D
------
P
Q
A
E
-
V
N
-------
K
G
L
N
-
C
V
K
G
Y
F
L
S
K
I
M
Y
G
------
Q
-----
D
R
-
L
T
R
P
L
M
R
M
K
NGKYDKN-------------------------------
G
D
F
A
P
V
T
W
D
Q
A
F
D
E
M
E
-----
R
Q
F
K
R
V
L
K
E
K
G
P
T
---
A
V
G
M
F
----
G
----
S
G
Q
W
T
V
W
E
G
Y
-
A
---
A
----
A
----
K
---
L
Y
K
AGF
R
----
S
--
N
N
I
D
P
N
---------------------
A
R
H
C
M
A
S
A
A
A
G
F
M
R
-
T
F
G
--
M
DE
P
--
M
G
C
Y
-
D
D
F
E
-
A
A
D
A
F
V
L
W
---------------
G
S
N
M
A
E
M
H
P
I
-
L
---------
W
--
T
R
-------
V
----
T
---
D
R
R
----
L
S
---
H
--------------------------------
P
K
T
R
V
V
V
L
S
T
F
---------------
T
H
R
C
F
D
------
L
-
A
D
--------
I
G
I
I
F
K
P
Q
T
---------
D
L
A
M
L
N
Y
I
A
N
Y
I
I
R
N
N
KVN
K
D
F
V
N
K
H
T
V
F
K
E
G
V
T
DIGYGLRPDH
P
L
Q
K
A
AKNASDPG
A
A
K
V
I
T
F
D
E
F
A
K
F
V
SKYD-------------------------------------------------------------------------------------------------------------------------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
V
S
K
L
S
A
-----
V
P
K
A
K
L
D
Q
L
A
E
L
Y
A
D
P
-----
N
I
-----
K
-------------
V
M
S
L
--
W
T
M
G
F
N
-
Q
-
H
----
T
R
G
T
W
A
N
N
M
V
Y
N
L
H
L
L
T
G
KIAT
P
G
N
S
P
-----------
F
S
--------
L
T
------------
G
Q
-----------
P
S
-----
A
C
---
G
T
A
R
----------------
E
-----------------------------------------------
V
-----------------------------------------------
G
---------
T
----------------------------------
F
SHRLPADMVVTN
P
K
H
R
E
E
A
E
R
I
W
KLPPGTIPDK---
P
G-----------------------
Y
--------------------------
D
A
V
L
Q
N
---------------------
R
-----------------
M
----
L
------------
K
D
-----------
G
---
K
L
N
A
Y
W
V
Q
V
N
-
N
N
M
Q
------
A
A
A
N
--
L
----
M
------------------------------
E
------------------------------
E
G
L
-
P
G
Y
R
N
P
A
-
N
-
F
I
V
V
S
D
A
Y
P
T
V
-
T
A
-
L
A
A
D
L
V
L
P
S
A
-
M
W
V
E
K
E
G
A
Y
-
G
-
N
---
A
-
E
---
R
--
R
--
T
Q
F
W
H
Q
L
V
D
A
P
-
G
----
E
A
R
S
D
L
W
Q
L
V
E
F
A
K
R
F
K
V
E
--------------
E
--------------
V
---
W
P----------
P
-----
E
L
I
A
K
K
P
E
YKGKT
L
Y
D
V
L
YRNGQVDKFP
L
K
D
V
N
A
----------------
E
Y
-----------------------------------
H
N
A
E
A
K
-------
A
--
F
-----
G
F
Y
------
L
Q
K
G
L
F
----
E
---
E
Y
A
T
F
--------
G
R
--
G
-----------
H
--------------------------------
G
---------
H
D
L
A
-------------
P
F
D
--------
A
Y
H
E
A
R
G
L
R
W
P
V
V
N
-----
G
-----
K
-----
E
--
T
R
W
-
R
-
Y
R
E
GSDPYVKAGTGF
Q
F
Y
G
----
N
P
---------
D
G
K
A
--
V
I
F
A
----------------------------------------
L
P
--
Y
E
---------------------------
P
P
A
E
S
P
D
K
E
Y
P
Y
W
L
----------------------------------------------
V
T
G
R
--
V
LE
H
W
H
S
G
S
M
T
R
R
-
V
-
P
E
L
Y
R
S
-
F
---
P
N
A
------
V
V
F
M
H
P
E
D
A
K
A
L
G
L
R
R
G
V
E
V
E
V
V
S
R
R
G
R
M
R
--
S
R
I
E
T
RG
R
D
A
P
P
R
G
L
V
------------------
F
V
P
W
F
D
A
S
QL
I
--
N
K
V
T
L
-----------------------------------------------------
45
HHSearch
55.18
14%
7
- C2 -
-
2IVF
9
?
A:
[73-924]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------
D
K
---------
V
N
W
G
S
H
L
-
N
I
C
W
PQ
G
S
C
K
F
Y
V
-
Y
V
R
-----------------------------------------
N
G
-----------------------------
I
V
--
W
R
---------
E
E
Q
-------
A
------
A
Q
T
P
-
A
C
NVDYVDY
N
P
L
G
-
C
Q
K
G
S
A
F
N
N
N
L
Y
G
------
D
-----
E
R
-
V
K
Y
P
L
K
R
V
G
KRGE----------------------------------
G
K
W
K
R
V
S
W
D
E
A
A
G
D
I
A
-----
D
S
I
I
D
S
F
E
A
Q
G
S
D
---
G
F
I
L
D----
A
PHVH
A
G
S
I
A
W
G
A
G
F
-
R
---
M
----
T
----
Y
---
L
M
----
D
G
V
S
P
D
--
I
N
V
D
I
G
----------------------
D
T
Y
M
-
G
---
A
F
-
H
-
T
F
G
--
K
MH
M
--
G
Y
S
A
-
D
N
L
L
-
D
A
E
L
I
F
M
T
---------------
C
S
N
W
S
Y
T
Y
P
S
-
S
---------
Y
--
H
F
-------
L
----
S
---
E
A
R
----
Y
----
K
---------------------------------
G
A
E
V
V
V
I
A
P
D
---------------
F
N
P
T
T
P
------
A
-
A
D
--------
L
H
V
P
V
R
V
G
S
---------
D
A
A
F
W
L
G
L
S
Q
V
M
I
D
E
K
LFD
R
Q
F
V
C
E
QTDLP
L
L
V
R
MDTGKFLSAEDVDGGEAK
Q
F
Y
F
F
D
EKAG
S
V
R
K
A
S
RGTLKLDFMPAL
E
G
T
F
S
A
R
L
KNG
K
T
I
Q
V
R
T
V
F
E
G
L
R
E
H
L
K
DYT-------------------------------------------------------------------------------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
A
S
A
K
C
G
-----
V
P
V
S
L
I
R
E
L
G
R
K
V
A
K
K
------------
R
-------------
T
C
S
Y
--
I
G
F
S
S
A
-
K
-
S
----
Y
H
G
D
L
M
E
R
S
L
F
L
A
M
A
L
S
G
NWGK
P
G
T
G
A
-----------
F
A
--------
W
A
YSD
D
N
M
V
Y
L
G
VM
S
K
-----------
P
T
-----
A
Q
---
G
G
-
M
----------------
D
E
L
H
Q
M
A
E
G
F
N
K
R
T
L
E
A
DPTST
D
E
M
G
N
I
E
F
M
K
V
V
T
S
A
-----------
V
-----------------------------------------------
G
---------
L
----------------------------------
V
P-----------------------------------
P
A
M
W
L
Y
Y
HVGY
D
Q
L
W
N
NKAWTDPA-
L
KKS
F
----------------------
G
--------------------------
A
Y
L
D
E
A
K
E
K
GWWTNDHIR
P
----
A
------------
P
------------
D
K
--
T
P
Q
V
Y
M
L
L
S
Q
-
N
P
M
R
------
R
K
R
S
G
A
K
M
---
F
------------------------------
P
D
-----------------------------
V
L
F
-
P
----
K
L
-
K
-
M
I
F
A
L
E
T
R
M
S
S
-
S
A
-
M
Y
A
D
I
V
L
P
C
A
-
W
Y
Y
E
K
H
E
M
T
-
T
-
P
---
C
-
S
---
G
NP
F
--
F
T
F
V
D
R
S
V
A
P
P
-
G
----
E
C
R
E
E
W
D
A
I
A
L
I
L
K
K
V
G
E
R
--------------
A
A
A
R
GL
T
E
-------
F
---
N
-----------
D
HNG
R
K
R
------
R
YDE
L
Y
K
K
F
T
M
DGHLLT----
N
E
D
C
L
K
----------------
E
M
-----------------------------------
V
D
I
N
R
A
V
GVF---
A
--
K
-----
D
Y
T
-----------
Y
----
E
---
K
F
K
K
E
--------
G
Q
TR
F
-----------
L
SMG-----------------------------
T
---------
G
V
-
S
-------------
R
Y
A
--------
H
A
---
N
E
V
D
-
V
T
K
P
-----
I
-----
Y
-----
P
-
M
R
W
H
-
F
-
D
D
K
------------
K
V
F
P
----
T
H
---------
T
R
R
A
--
Q
F
Y
L
D
--
H
D
W
-----
Y
--
L
E
----------
A
----------
G
E
S
L
P
T
-
H
K
D
---------------------------
T
P
-
M
V
G
G
D
H
P
F
K
I
----------------------------------------------
T
G
G
H
--
P
--
R
V
S
I
H
S
T
H
L
T
-
N
-
S
H
L
S
R
L
-
H
R--
G
Q
P
------
V
V
H
M
N
S
K
D
A
A
E
L
G
I
K
D
G
D
M
A
K
L
F
N
D
F
A
D
C
E
--
I
M
V
R
T
--
A
P
N
V
Q
P
K
Q
C
------------------
I
V
Y
F
W
D
A
H
---------------------------------------------------------------
32
HHSearch
53.47
14%
0
- C- -
-
1G8K
-
AIOA_ALCFA
E:
[9-786]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
A
-------
N
A
---------
Q
R
T
N
M
T
C
-
H
F
C
I
--
V
G
C
G
Y
H
V
-
Y
K
W
PELEE------------------------------------
G
G
RAPEQNALGLDFRKQLPPLAVTLTPAMTN
V
V
--
T
E
HDGARYDIM
V
V
P
-------
D
------
K
A
C
V
-
V
N
-------
S
G
L
S
-
S
T
R
G
G
K
M
A
S
Y
M
Y
T
------
P
TGDGK
E
R
-
L
S
A
P
R
L
Y
A
A
--------------------------------------
D
E
W
V
D
T
T
W
D
H
A
M
A
LY
A
-----
G
L
I
K
K
TLDK
D
G
P
Q
---
G
V
F
F
S----
C
FDHG
G
A
G
G
G
F
E
N
T
W
-
G
---
T
----
G
----
K
---
L
M
FSAI
Q
----
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--
P
M
V
R
I
H
---
N
R
P
A-------------
Y
N
S
E
C
H
A
T
R
E
----
M
-
G
I
G
--
E
--
L
--
N
N
A
Y
-
E
D
A
Q
-
L
A
D
V
I
W
S
I
---------------
G
N
N
P
Y
E
S
Q
T
N
-
Y
---------
F
LN
H
W
-------
L
----
P
NLQ
G
A
T
TSKK
K
E
---
R
F
----------------
P
N
--
E
N
F
--------
P
Q
A
R
I
I
F
V
D
P
R
---------------
E
T
P
S
V
A
------
I
-
A
R
HVAGNDRV
L
H
L
A
I
E
P
G
T
---------
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
G
WIDKPFIEAHTKGFDDAVKTNRLS------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
C
SNI
T
G
-----
V
P
V
D
M
L
K
R
A
A
E
W
S
Y
K
P
-----
K
ASGQAP
R
-------------
T
M
H
A
--
Y
E
K
G
I
I
-
W
-
G
----
N
DNYV
I
Q
S
A
L
L
D
L
V
I
A
T
H
NVGR
R
G
T
G
C
-----------
V
R
--------
M
G
------------
G
H
-----------
Q
E
-----
G
Y
---
T
R
-
P
----------------
P
-----------------------------------------------
Y
-----------------------------------------------
P
---------
G
----------------------------------
D
K-----------------------------------
K
------------------------
I
YI------------------------
D
Q-------------------------
E
-----------------
L
----
I
------------
K
------------
G
---
K
G
R
I
M
T
W
W
G
C
-
N
N
F
Q
------
T
S
N
N
A
Q
A
----
L
------------------------------
R
EAILQRSAIVKQAMQKARGATTEEMVDVIY
E
A
T
-
Q
----
N
G
G
L
-
F
V
T
S
I
N
L
Y
P
T
K
-
L
A
-
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A
A
H
L
M
L
P
A
A
-
H
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L
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-
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-
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---
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---
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--
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--
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----
T
A
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A
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L
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A
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I
A
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A
L
R
D
M
YQKDGKAEMAAQFE
G
--------------
F
---
D
-----------
W
-----
K
------
T
--------------------
E
E
D
A
F
N
----------------
D
G
-----------------------------------
F
R
R
A
G
Q
-------
P
GA
P
-----
A
I
D
S
Q
G
GST
G
H
L
V
T
Y
----
D
---
R
L
R
K
S
--------
G
N
------------------------------------------------------------------------------------------
N
G
V
Q
L
P
V
V
S
-----
W
-----
D
ESKGL
V
-
G
T
E
M
-
L
-
Y
T
E
------------
G
K
F
D
----
T
D
---------
D
G
K
A
--
H
F
K
P
A
--
P
W
N
---------------------------------
G
L
P
A
-
T
V
Q
------------------------------
Q
Q
K
D
K
Y
R
F
W
L
----------------------------------------------
N
N
G
R
NN
E
--
V
W
Q
T
A
Y
H
D
Q
Y
-
N
-
S
L
M
Q
E
R
-
Y
---
P
M
A
------
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
G
G
D
I
V
E
V
Y
N
D
F
G
S
T
F
--
A
M
V
Y
P
--
V
A
E
I
K
R
G
Q
T
------------------
F
M
L
F
G
Y
V
N
--
G
IQ
G
D
V
T
T
-----------------------------------------------------
38
HHSearch
52.94
16%
27
- C2 -
-
4YDD
10
?
A:
[20-840]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
W
S
W
-------
D
K
---------
K
T
R
G
A
H
L
-
V
N
C
T
--
G
A
C
P
H
F
V
-
Y
S
K
-----------------------------------------
D
G
-----------------------------
V
V
--
M
R
---------
E
E
Q
-------
S
KDIAPM
P
N
I
P
-
E
Y
-------
N
P
R
G
-
C
N
K
G
E
C
G
H
D
Y
M
Y
G
------
P
-----
H
R
-
I
K
Y
P
L
I
R
V
G
ERGE----------------------------------
G
K
W
R
R
A
T
W
E
E
A
L
D
M
I
A
-----
D
K
C
V
D
T
I
K
N
H
A
P
D
---
C
I
S
V
Y
----
S
----
P
V
P
A
V
S
P
V
S
F
S
A
---
G
----
H
----
R
---
F
A
H
Y
I
-
G
----
A
--
H
A
H
T
F
Y
---
D
W
Y
---------------
G
D
H
P
T
-
G
---
Q
T
-
Q
-
T
C
G
--
V
Q
G
D
--
T
C
E
T
-
A
D
W
F
-
N
S
K
Y
I
I
L
W
---------------
G
S
N
P
T
Q
T
R
I
P
-
D
---------
A
--
H
F
-------
L
----
S
---
E
A
Q
----
L
----
N
---------------------------------
G
A
K
I
V
S
I
S
P
D
---------------
Y
N
S
S
T
I
------
K
-
V
D
--------
K
W
I
H
P
Q
P
G
T
---------
D
G
A
L
A
M
A
M
A
H
V
I
I
K
E
K
LYD
A
H
S
L
K
E
QTDLS
Y
L
V
R
SDTKRFLREADVVAGGSKD
K
F
Y
F
W
NAKTG
K
P
V
I
P
K
GSWGDQPE
K
K
G
S
P
VGFLGRNTFAFPKGYIDLGD
L
D
P
A
L
E
G
K
F
N
M
Q
L
LDG
K
T
V
E
V
R
P
V
F
E
I
L
K
S
R
L
M
A
DNT---------------------------------------------------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
A
A
K
I
T
G
-----
V
T
A
K
A
I
T
E
L
A
R
E
F
A
T
A
-----
K
------
P
-------------
S
M
I
I
--
C
G
G
G
T
Q
-
H
-
W
----
Y
Y
S
D
V
L
L
R
A
M
H
L
L
T
A
L
T
G
TEGT
N
G
G
G
M
-----------
N
H
--------
Y
I
------------
G
Q
-----------
W
K
-----
P
A
F
V
A
G
L
-
V
----------------
A
L
A
FPEGVNK
Q
R
F
C
Q---------------------------------
T
-----------------------------------------------
T
---------
I
----------------------------------
W
------------------------------------
T
Y
I
H
A
EVNDEIISSDID
T
E
K
Y
L
R
D
S
I
--------------------------
T
T
G------------------------
Q
-----------------
M
P
N
M
-
P
E-----------
Q
------------
G
R--
D
P
K
V
F
F
V
Y
R
G
-
N
W
L
N
------
Q
A
K
G
Q
K
Y
----
V
------------------------------
L
------------------------------
E
N
L
W
P
----
K
L
-
E
-
L
I
V
D
I
N
I
R
M
D
S
-
T
A
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L
Y
S
D
V
V
L
P
S
A
-
H
W
Y
E
K
L
D
L
N
-
V
T
S
---
E
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H
---
S
--
Y
--
I
N
M
T
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P
A
I
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P
M
-
W
----
E
S
K
T
D
W
Q
I
F
L
A
L
A
K
R
V
E
M
A
--------------
A
K
-------------
R
K
--
K
-----------
Y
EKF--
N
------
D
EKFKWVRD------------
L
S
N
L
W
N
Q
M
T
M
DGKLAE
D
E
A
A
A
Q
Y
I
-----------------------------------
L
D
N
A
P
Q
-------
S
--
K
-----
G
I
T
-----------
I
----
Q
---
M
L
R
E
K
--------
P
Q
--
R
-----------
F
----------------------------------------------------------------------------
K
S
N
W
T
S
P
L
K
EG
V
P
Y
-----
T
-----
P
-
F
Q
Y
F
-
V
-
V
D
K
------------
K
P
W
P
----
T
L
---------
T
G
R
Q
--
Q
F
Y
L
D
--
H
D
T
-----
F
F
-----------
D
-
M
G
----------
V
E
L
P
T
-
Y
K
A
---------------------------
P
I
--
D
A
D
K
Y
P
F
R
F
----------------------------------------------
N
S
P
H
--
S
--
R
H
S
V
H
S
T
F
K
D
N
V
-
L
M
L
R
L
Q
-
R
---
G
G
P
------
S
I
E
M
S
P
L
D
A
K
P
L
G
I
K
D
N
D
W
V
E
A
W
N
N
H
G
K
V
I
--
C
R
V
K
I
--
R
N
G
E
Q
R
G
R
V
------------------
S
M
W
H
C
P
E
L
--
Y
------------------------------------------------------------
42
HHSearch
52.79
17%
26
- C2 -
-
2NYA
3
NAPA_ECOLI
F:
[3-771]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---------
K
W
D
K
A
P
C
-
R
F
C
G
--
T
G
C
G
V
L
V
-
G
T
Q
-----------------------------------------
Q
G
-----------------------------
R
V
--
V
A
---------
C
Q
G
-------
D
------
P
D
A
P
-
V
N
-------
R
G
L
N
-
C
I
K
G
Y
F
L
P
K
I
M
Y
G
------
K
-----
D
R
-
L
T
Q
P
L
L
R
M
K
NGKYDKE-------------------------------
G
E
F
T
P
I
T
W
D
Q
A
F
D
VM
E
-----
E
K
F
K
T
ALKE
K
G
P
E
---
S
I
G
M
F----
G
----
S
G
Q
W
T
I
W
E
G
Y
-
A
---
A
----
S
----
K
---
L
F
KAGF
R
----
S
--
N
N
I
D
P
N
---------------------
A
R
H
C
M
A
S
A
V
V
G
F
M
R
-
T
F
G
--
M
DE
P
--
M
G
C
Y
-
D
D
I
E
-
Q
A
D
A
F
V
L
W
---------------
G
A
N
M
A
E
M
H
P
I
-
L
---------
W
--
S
R
-------
I
----
T
---
N
R
R
----
L
S
---
N
--------------------------------
Q
N
V
T
V
A
V
L
S
T
Y
---------------
Q
H
R
S
F
E
------
L
-
A
D
--------
N
G
I
I
F
T
P
Q
S
---------
D
L
V
I
L
N
Y
I
A
N
Y
I
I
Q
N
N
AINQDFFSKHVNLRKGATDIGYGLRPTHPLEKAAKNPGSDASEPMSFEDYKAFVAEYT--------------------------------------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
T
AEM
T
G
-----
V
P
K
D
Q
L
E
Q
L
A
Q
L
Y
A
D
P
-----
N
K-----
K
-------------
V
I
S
Y
--
W
T
M
G
F
N
-
Q
-
H
----
T
RGVW
A
N
N
L
V
Y
N
L
H
L
L
T
G
KISQ
P
G
C
G
P
-----------
F
S
--------
L
T
------------
G
Q
-----------
P
S
-----
A
C
---
G
T
A
R
----------------
E
-----------------------------------------------
V
-----------------------------------------------
G
---------
T
----------------------------------
F
AHRLPADMVVTNEKHRDICEKKWNIPSGTI------
P
------------------------
A
KIGL----------------------
H
AVAQD---------------------
R
-----------------
A
----
L
------------
K
D-----------
G
---
K
L
N
V
Y
W
T
M
C
T
-
N
N
M
Q
------
A
G
P
N
I
N
E
----
E
------------------------------
R
MP----------------------------
G
W
R
-
D
----
P
R
-
N
-
F
I
I
V
S
D
P
Y
P
T
V
-
S
A
-
L
A
A
D
L
I
L
P
T
A
-
M
W
V
E
K
E
G
A
Y
-
G
-
N
---
A
-
E
---
R
--
R
--
T
Q
F
W
R
Q
Q
V
Q
A
P
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G
----
E
A
K
S
D
L
W
Q
L
V
Q
F
S
R
R
F
K
T
E
--------------
E
--------------
V
---
W
-----------
P
-----
E
------
D
--------------------
L
L
A
K
K
P
ELRGKTLY--------
E
V
-----------------------------------
L
Y
A
T
P
E
-------
V
--
S
-----
K
F
P
-----------
V
----
S
---
E
L
A
E
D
QLNDESRE
L
G
--
F
-----------
Y
--------------------------------
L
---------
Q
K
-
G
-------------
L
F
E
--------------
E
Y
A
W
F
G
R
G
-----
H
-----
G
-----
H
D
L
A
P
F
D
D
Y
H
K
A
------------
R
G
L
R
----
W
P
VV-------
N
G
K
E
TQ
W
R
Y
S
E
--
G
N
D
-----
P
--
Y
V
K
A
G
E
-----
G
Y
K
-
F
Y
G
K
---
P
D
G
K
A
V
I
-
F
A
L
P
F
----------------------
E
-
P
A
A
E
A
P
D
E
E
Y
D
L
W
L
----------------------------------------------
S
T
G
R
--
V
LE
H
W
H
T
G
S
M
T
R
R
-
V
-
P
E
L
H
R
A
-
F
---
P
E
A
------
V
L
F
I
H
P
L
D
A
K
A
R
D
L
R
R
G
D
K
V
K
V
V
S
R
R
G
E
V
I
--
S
I
V
E
T
RG
R
N
R
P
P
Q
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L
V
------------------
Y
M
P
F
F
D
A
A
--
Q
LV
N
K
L
T
L
--
D
--------------------------------------------------
33
HHSearch
52.04
16%
28
- C2 -
-
5E7O
-
?
I:
[20-840]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
W
S
W
-------
D
K
---------
K
T
R
G
A
H
L
-
V
N
C
T
--
G
A
C
P
H
F
V
-
Y
S
K
-----------------------------------------
D
G
-----------------------------
V
V
--
M
R
---------
E
E
Q
-------
S
KDIAPM
P
N
I
P
-
E
Y
-------
N
P
R
G
-
C
N
K
G
E
C
G
H
D
Y
M
Y
G
------
P
-----
H
R
-
I
K
Y
P
L
I
R
V
G
ERGE----------------------------------
G
K
W
R
R
A
T
W
E
E
A
L
D
MI
A
-----
D
K
C
V
D
TIKN
H
A
P
D
---
C
I
S
V
Y----
S
----
P
V
P
A
V
S
P
V
S
F
S
A
---
G
----
H
----
R
FAH
Y
I
----
G
----
A
--
H
A
H
T
F
Y
---
D
W
Y
---------------
G
D
H
P
T
-
G
---
Q
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-
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-
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--
V
QG
D
--
T
C
E
T
-
A
D
W
F
-
N
S
K
Y
I
I
L
W
---------------
G
S
N
P
T
Q
T
R
I
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-
D
---------
A
--
H
F
-------
L
----
S
---
E
A
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----
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----
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---------------------------------
G
A
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D
---------------
Y
N
S
S
T
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------
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-
V
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--------
K
W
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H
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Q
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T
---------
D
G
A
L
A
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A
M
A
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V
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K
E
K
LYDAHSLKEQTDLSYLVRSDTKRFLREADVVAGGSKDKFYFWNAKTGKPVIPKGSWGDQPEKKGSPVGFLGRNTFAFPKGYIDLGDLDPALEGKFNMQLLDGKTVEVRPVFEILKSRLMADNT---------------------------------------------------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
A
AKI
T
G
-----
V
T
A
K
A
I
T
E
L
A
R
E
F
A
T
A
-----
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------
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-------------
S
M
I
I
--
C
G
G
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-
H
-
W
----
Y
YSDV
L
L
R
A
M
H
L
L
T
A
L
T
G
TEGT
N
G
G
G
M
-----------
N
H
--------
Y
I
------------
G
Q
-----------
E
K
-----
P
A
FVA
G
L
-
V
----------------
A
LA---------------------------------------------
F
PEGVNKQRFCQT-----------------------------------
T
---------
I
----------------------------------
W
------------------------------------
T
YIHAEVNDEIISSDIDTEKYLRDS
I
--------------------------
T
TG------------------------
Q
MPN--------------
M
----
P
------------
E
Q-----------
G
R--
D
P
K
V
F
F
V
Y
R
G
-
N
W
L
N
------
Q
A
K
G
Q
K
Y
----
V
------------------------------
L
------------------------------
E
N
L
W
P
----
K
L
-
E
-
L
I
V
D
I
N
I
R
M
D
S
-
T
A
-
L
Y
S
D
V
V
L
P
S
A
-
H
W
Y
E
K
L
D
L
N
V
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Y
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M
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W
----
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S
K
T
D
W
Q
I
F
L
A
L
A
K
R
V
E
M
A
--------------
A
K-------------
R
---
K
K----------
Y
EKF--
N
------
D
EKFKWVRD------------
L
S
N
L
W
N
QMTMDGKLAEDEAAAQ
Y
I
-----------------------------------
L
D
N
A
P
Q
-------
S
--
K
-----
G
I
T
-----------
I
----
Q
---
M
L
R
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K
--------
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--
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-----------
F
----------------------------------------------------------------------------
K
S
N
W
T
S
P
L
KEGVP
Y
-----
T
-----
P
-
F
Q
Y
F
-
V
-
V
D
K
------------
K
P
W
P
----
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L
---------
T
G
R
Q
--
Q
F
Y
L
D
--
H
D
T
-----
F
F
------------
D
M
G
----------
V
E
L
P
T
-
Y
K
A
---------------------------
P
I
--
D
A
D
K
Y
P
F
R
F
----------------------------------------------
N
S
P
H
--
S
--
R
H
S
V
H
S
T
F
K
D
-
N
V
L
M
L
R
L
Q
-
R
---
G
G
P
------
S
I
E
M
S
P
L
D
A
K
P
L
G
I
K
D
N
D
W
V
E
A
W
N
N
H
G
K
V
I
--
C
R
V
K
I
--
R
N
G
E
Q
R
G
R
V
------------------
S
M
W
H
C
P
E
L
--
Y
------------------------------------------------------------
29
HHSearch
50.52
16%
17
- C2 -
-
1Q16
3
NARG_ECOLI
A:
[25-1167]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
N
-
T
N
R
D
W
-------
E
D
G
Y
R
Q
R
W
QHD
K
I
V
R
S
T
H
G
V
N
C
T
--
G
S
C
S
W
K
I
-
Y
V
K
-----------------------------------------
N
G
-----------------------------
L
V
--
T
W
---------
E
T
Q
Q
TDYPRT
R
------
P
D
L
P
-
N
H
-------
E
P
R
G
-
C
P
R
G
A
S
Y
S
W
Y
L
Y
S
------
A
-----
N
R
-
L
K
Y
P
M
M
R
K
R
L
M
K
M
W
R
E
A
K
A
L
H
SD
P
V
E
A
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A
S
I
I
E
D
A
D
K
A
K
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F
K
Q
A
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G
G
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V
R
S
S
W
Q
E
V
N
E
L
I
A
-----
A
S
N
V
Y
T
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K
N
Y
G
P
D
---
R
V
A
G
F
----
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----
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P
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M
V
S
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-
A
---
S
G
A
R
Y
L
----
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---
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----
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----
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--
T
C
L
S
F
Y
---------------------
D
W
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L
P
P
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S
P
--
Q
-
T
W
G
--
E
--
Q
T
D
V
P
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S
-
A
D
W
Y
-
N
S
S
Y
I
I
A
W
---------------
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S
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V
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Q
T
R
T
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-
D
---------
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--
H
F
-------
F
----
T
---
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V
R
----
Y
----
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---------------------------------
G
T
K
T
V
A
V
T
P
D
---------------
Y
A
E
I
A
K
------
L
-
C
D
--------
L
W
L
A
P
K
Q
G
T
---------
D
A
A
M
A
L
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M
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V
M
L
R
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
LDNPS
Q
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TDMP
M
L
V
M
L
E
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R
DGYYAAGRMLRAADLVDALGQENNPEW
K
T
V
A
F
N
TNG
E
M
V
A
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N
GS
I
G
F
R
W
GEKGKWNLEQRDGKTG
E
E
T
E
L
Q
L
S
LLGSQD
E
I
A
E
V
G
F
P
Y
FGGDGTEH
F
N
K
V
E
L
E
N
V
L
L
H
K
L
P
V
K
R
L
Q
L
ADG
S
T
A
L
V
T
T
V
Y
D
L
T
L
A
N
Y
GLERGLNDVNCATSYDDVKAYT
P
A
W
A
E
Q
I
T
G
-----
V
S
R
S
Q
I
I
R
I
A
R
E
F
A
D
N
A
D
K
T
H
G
------
R
-------------
S
M
I
I
--
V
G
A
G
L
N
-
H
-
W
----
Y
H
L
D
M
N
Y
R
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L
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M
L
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C
G
CVGQ
S
G
G
G
W
-----------
A
H
--------
Y
V
------------
G
Q
-----------
E
K
-----
L
R
---
P
Q
-
T
GW
Q
P
L
A
F
ALDWQRP
A
R
H
-----------------------------------------------
M
N
S
T
S
Y
F
Y
N
HSSQWRYETVTAEELLSPMADKSR
Y
T
G
H
L
I
D
F
N
V
R
A
E
R
M
G
---------
W
----------------------------------
L
------------------------------------
P
------------------------
S
--------------------------
A
PQLGTNPLT
I
A
G
E
A
E
K
A
GMN
P
V
D
Y
T
V
K
S
----------------
L
----
K
E
GSIRFAAEQP-
E
N-----------
G
KN-
H
P
R
N
L
F
I
W
R
S
-
N
L
L
G
------
S
S
G
K
G
H
E
F
---
M
L
K
YLLGTEHGIQGKDLGQQGGVKPEE
V
D
W
Q
D
------------------------------
N
G
L
E
G
----
K
L
-
D
-
L
V
V
T
L
D
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R
L
S
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-
T
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L
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A
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T
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N
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T
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---
D
M
H
---
P
--
F
--
I
H
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L
S
A
A
V
D
P
A
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W
----
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A
K
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D
W
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Y
K
A
I
A
K
K
F
S
E
V
--------------
C
--------------
V
GHL
G
K
E
T
D
I
V
T
L
P
--
I
QH---
D
------
S
--------------------
A
A
E
L
A
Q
----------------
P
L
D
V
K
D
WKKGECDLIPGKTA
P
H
I
M
V
V
E
R
DYPA
T
Y
E
R
F
T
S
I
G
P
L
M
E
K
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G
--
K
-----
G
I
A
W
-
N
---
T
Q
S
-
E
M
----
D
---
L
L
R
K
L
--------
N
Y
--
T
KAEGPAKGQPM
L
NT
A
I
D
A
A
E
M
I
L
T
L
APETN
G
Q
V
A
V
K
A
W
A
A
L
S
E
F
T
---------
G
R
-
D
HTHLALNKED
E
K
I
R
F
R
D
I
Q
A
Q
P
R
K
I
I
---
S
S
P
T
W
S
G
L
E
-----
D
-----
E
HV
S
Y
N
A
-
G
Y
T
N
-
V
-
H
E
L
------------
I
P
W
R
----
T
L
---------
S
G
R
Q
--
Q
L
Y
Q
D
H
Q
W
M
R
-----
D
F
--------------
G
----------
E
S
L
L
V
-
Y
R
P
P
I
D
T
R
S
V
---------------
K
E
V
I
G
Q
K
S
N
G
N
Q
E
K
A
L
N
F
----------------------------------------------
L
T
P
H
--
Q
--
K
W
G
I
H
S
T
Y
S
D
-
N
-
L
L
M
L
T
L
-
G
R--
G
G
P
------
V
V
W
L
S
E
A
D
A
K
D
L
G
I
A
D
N
D
W
I
E
V
F
N
S
N
G
A
L
T
--
A
R
A
V
V
--
S
Q
R
V
P
A
G
M
T
------------------
M
M
Y
H
A
Q
E
----------------------------------------------------------------
26
HHSearch
50.35
14%
2
* C2 *
-
2VPZ
4
?
A:
[34-701]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
-------
E
V
---------
K
S
V
Y
Q
I
C
-
E
G
C
F
--
W
R
C
G
I
V
A
-
H
A
V
-----------------------------------------
G
N
-----------------------------
R
V
--
Y
K
---------
V
E
G
-------
Y
------
E
A
N
P
-
K
S
-------
R
G
R
L
-
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
------
P
-----
D
R
-
L
K
R
P
L
I
R
V
E
GSQRGE--------------------------------
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
-----
K
K
M
L
E
I
R
E
K
Y
G
P
E
---
A
I
A
F
F
----
G
----
H
G
T
G
----
D
Y
-
W
---
F
----
V
DF
L
P
A
---
A
W
----
G
----
S
--
P
N
A
A
K
P
---
S
-----------------
V
S
L
C
T
A
P
R
E
V
A
S
Q
W
-
V
F
G
--
R
PI
G
--
G
H
E
P
-
I
D
W
E
-
N
A
R
Y
I
V
L
I
---------------
G
H
H
I
G
E
D
T
H
N
T
Q
---------
L
--
Q
D
-------
F
----
A
---
L
A
L
----
K
----
N
---------------------------------
G
A
K
V
V
V
V
D
P
R
---------------
F
S
T
A
A
A
------
K
-
A
H
--------
R
W
L
P
I
K
P
G
T
---------
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
LYD
K
E
Y
V
A
K
YTVG
F
E
E
L
K
A
H
V
KDFT-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
A
E
K
H
T
E
-----
I
P
A
Q
V
I
R
E
V
A
R
E
M
A
A
H
-----
K
------
P
-------------
R
A
V
L
--
P
P
T
R
H
N
V
W
-
Y
GD
D
T
Y
----
R
V
M
A
L
L
Y
V
N
V
L
L
G
NYGR
P
G
G
F
Y
-----------
I
A
--------
Q
S
------------
P
Y
L
E
K
YPLPPLP
L
E
P
-----
A
A
---
G
G
-
C
----------------
S
-----------------------------------------------
G
-----------------------------------------------
P
SGGDHEPEG
F
----------------------------------
K
------------------------------------
P
RADKGKFFA---------------
R
STA
I
----------------------
Q
--------------------------
E
-----------------
L
I
E
P
M
I
------------
T
------------
G
EPY
P
I
K
G
L
F
A
Y
G
I
-
N
L
F
H
------
S
I
P
N
V
P
R
----
T
------------------------------
K
------------------------------
E
A
L
-
K
----
N
L
-
D
-
L
Y
V
A
I
D
V
L
P
Q
E
-
H
V
-
M
W
A
D
V
I
L
P
E
A
-
T
Y
L
E
R
Y
D
D
F
-
V
-
L
---
V
-
A
HK
T
P
--
F
--
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Q
L
R
T
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A
H
E
P
L
-
F
----
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
E
--------------
Q
Y-------------
F
---
P
-----------
W
-----
K
------
T
--------------------
I
E
E
Y
L
E
----------------
T
R
-----------------------------------
L
Q
S
L
------------------
G
L
D
-----------
L
----
E
---
T
M
K
G
M
--------
G
T
--
L
-----------
V
-------------------------------------------------------------
Q
-------------
R
G
K
P
W
L
E
D
----------------------
W
E
-
K
-
E
G
R
------------
L
P
F
G
----
T
A
---------
S
G
K
I
--
E
L
Y
C
Q
--
R
F
K
-----
E
A
-----------------------
G
H
Q
P
L
P
V
-
F
T
P
P
---------------------------
E
--
E
P
P
E
G
F
Y
R
L
----------------------------------------------
L
Y
G
R
--
S
--
P
V
H
T
F
A
R
T
Q
N
-
N
-
W
V
L
M
E
M
-
D
---
P
E
N
------
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
E
G
P
V
R
V
K
P
--
T
A
R
I
R
K
D
C
V
------------------
Y
I
V
H
G
F
G
H
---------------------------------------------------------------
27
HHSearch
49.28
14%
5
- C2 -
-
2VPY
4
?
E:
[34-701]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
-------
E
V
---------
K
S
V
Y
Q
I
C
-
E
G
C
F
--
W
R
C
G
I
V
A
-
H
A
V
-----------------------------------------
G
N
-----------------------------
R
V
--
Y
K
---------
V
E
G
-------
Y
------
E
A
N
P
-
K
S
-------
R
G
R
L
-
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
------
P
-----
D
R
-
L
K
R
P
L
I
R
V
E
GSQRGE--------------------------------
G
K
Y
R
V
A
T
W
E
E
A
L
D
HI
A
-----
K
K
M
L
E
IREK
Y
G
P
E
---
A
I
A
F
F----
G
----
H
G
T
G
----
D
Y
-
W
---
F
----
V
DFLP
A
---
A
W
----
G
----
S
--
P
N
A
A
K
P
---
S
-----------------
V
S
L
C
T
A
P
R
E
V
A
S
Q
W
-
V
F
G
--
R
PI
G
--
G
H
E
P
-
I
D
W
E
-
N
A
R
Y
I
V
L
I
---------------
G
H
H
I
G
E
D
T
H
N
T
Q
---------
L
--
Q
D
-------
F
----
A
---
L
A
L
----
K
----
N
---------------------------------
G
A
K
V
V
V
V
D
P
R
---------------
F
S
T
A
A
A
------
K
-
A
H
--------
R
W
L
P
I
K
P
G
T
---------
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
LYDKEYVAKYTVGFEELKAHVKDFT-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
A
EKH
T
E
-----
I
P
A
Q
V
I
R
E
V
A
R
E
M
A
A
H
-----
K
------
P
-------------
R
A
V
L
--
P
P
T
R
H
N
V
W
-
Y
GDDT
Y
----
R
V
M
A
L
L
Y
V
N
V
L
L
G
NYGR
P
G
G
F
Y
-----------
I
A
--------
Q
S
------------
P
Y
LEKYPLPPLPL
E
P
-----
A
A
---
G
G
-
C
----------------
S
-----------------------------------------------
G
-----------------------------------------------
P
SGGDHEPEG
F
----------------------------------
K
------------------------------------
P
RADKGKFFA---------------
R
STAI----------------------
Q
--------------------------
E
-----------------
L
IEPM
I
------------
T
------------
G
EPY
P
I
K
G
L
F
A
Y
G
I
-
N
L
F
H
------
S
I
P
N
V
P
R
----
T
------------------------------
K
------------------------------
E
A
L
-
K
----
N
L
-
D
-
L
Y
V
A
I
D
V
L
P
Q
E
-
H
V
-
M
W
A
D
V
I
L
P
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A
-
T
Y
L
E
R
Y
D
D
F
-
V
-
L
---
V
-
A
HKT
P
--
F
--
I
Q
L
R
T
P
A
H
E
P
L
-
F
----
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
E
--------------
Q
Y-------------
F
---
P
-----------
W
-----
K
------
T
--------------------
I
E
E
Y
L
E
----------------
T
R
-----------------------------------
L
Q
S
L
------------------
G
L
D
-----------
L
----
E
---
T
M
K
G
M
--------
G
T
--
L
-----------
V
-------------------------------------------------------------
Q
-------------
R
G
K
P
W
L
E
D
----------------------
W
E
-
K
-
E
G
R
------------
L
P
F
G
----
T
A
---------
S
G
K
I
--
E
L
Y
C
Q
--
R
F
K
-----
E
A
-----------------------
G
H
Q
P
L
P
V
-
F
T
P
P
---------------------------
E
--
E
P
P
E
G
F
Y
R
L
----------------------------------------------
L
Y
G
R
--
S
--
P
V
H
T
F
A
R
T
Q
N
-
N
-
W
V
L
M
E
M
-
D
---
P
E
N
------
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
E
GP
V
R
V
K
P
--
T
A
R
I
R
K
D
C
V
------------------
Y
I
V
H
G
F
G
H
---------------------------------------------------------------
41
HHSearch
48.25
13%
20
- C2 -
-
4AAY
4
?
C:
[11-797]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
I
P
A
-------
D
A
---------
K
K
H
N
V
T
C
-
H
F
C
I
--
V
G
C
G
Y
H
A
-
Y
T
W
PINKQGGTDPQNNIFGVDLSEQQQAESDAWYSPSMYNVVKQ
D
G
-----------------------------
R
D
VH
V
V
---------
I
K
P
-------
D
------
H
E
C
V
-
V
N
-------
S
G
L
G
-
S
V
R
G
A
R
M
A
E
T
S
F
S
EARNTQ
Q
-----
Q
R
-
L
T
D
P
L
V
W
R
Y
--------------------------------------
G
Q
M
Q
P
T
S
W
D
D
A
L
D
LV
A
-----
R
V
T
A
K
IVKE
K
G
E
D
---
A
L
I
V
SAFDH
G
----
G
A
G
G
G
Y
E
N
T
W
-
G
---
T
----
G
----
K
---
L
Y
FEAM
K
----
V
--
K
N
I
R
I
H
---------------------
N
R
P
A
Y
N
S
E
V
H
G
T
-
R
-
D
M
G
VG
E
--
L
--
N
N
C
Y
-
E
D
A
E
-
L
A
D
T
I
V
A
V
---------------
G
T
N
A
L
E
T
Q
T
N
-
Y
---------
F
LN
H
W
-------
I
----
P
---
N
L
R
----
G
E
SLG
K
K
K
E
--------------
L
M
P
E
E
P
H
--------
E
A
G
R
I
I
I
V
D
P
R
---------------
R
T
V
T
V
N
ACEQTA
G
-
A
D
NV------
L
H
L
A
I
N
S
G
T
---------
D
L
A
L
F
N
A
L
F
T
Y
I
A
D
K
G
WVDRDFIDKSTLREGTARPPLYPARGVSEANPGHLSSFEDAVEGCRMS------------------------------------------------------------------------------------------------------------------------------------------
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
AEI
T
G
-----
L
D
A
A
Q
I
I
K
A
A
E
W
I
G
M
P
-----
K
EGGK--
R
-------------
R
R
V
M
FG
Y
E
K
G
L
I
-
W
-
G
----
N
DNYR
T
N
G
A
L
V
N
L
A
L
A
T
G
NIGR
P
G
G
G
V
-----------
V
R
--------
L
G
------------
G
H
-----------
Q
E
-----
G
Y
---
V
R
-
P
SDA-------------
H
-----------------------------------------------
V
-----------------------------------------------
G
---------
R
PAAYVDQLLIGGQGGVHHI---------------
W
------------------------------------
G
CDH---------------------
Y
--------------------------
K
--------------------------
T
-----------------
T
----
L
------------
N
------------
A
H--
E
F
K
R
V
Y
K
K
R
T
-
D
M
V
K
DAMSAA
P
Y
G
D
R
E
A
MVNA
I
------------------------------
V
------------------------------
D
A
I
-
N
----
Q
G
G
L
-
F
A
V
N
V
D
I
I
P
T
K
-
I
G
-
E
A
C
H
V
I
L
P
A
A
-
T
S
G
E
M
N
L
T
S
-
M
-
N
---
G
-
E
---
R
--
R
--
M
R
L
T
E
R
Y
M
D
P
P
-
G
----
Q
S
M
P
D
C
L
I
A
A
R
L
A
N
T
M
E
R
V
--------------
L
TEMGDVGYAAQFKG
F
---
D
-----------
W
-----
Q
------
T
--------------------
E
E
D
A
F
M
----------------
D
G
Y----------------------------------
N
K
N
A
H
G
-------
G
--
E
-----
F
V
T
-----------
Y
----
E
---
R
L
S
A
M
--------
G
T
------------------------------------------------------------------------------------------
N
G
F
Q
E
P
A
T
G
-----
F
TDGK-
I
-----
E
-
G
T
Q
R
-
L
-
Y
T
D
------------
G
V
F
S
----
T
D
---------
D
G
K
A
--
R
F
M
D
A
--
P
W
R
-----
G
--------------------------------
L
Q
A
P
G
--------------------------
K
Q
Q
Q
K
D
S
H
K
Y
L
I
----------------------------------------------
N
N
G
R
AN
V
--
V
W
Q
S
A
Y
L
D
Q
E
-
N
-
D
F
V
M
D
R
-
F
---
P
Y
P
------
F
I
E
M
N
P
E
D
M
A
E
A
G
L
K
E
G
D
L
V
E
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D
A
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--
A
M
A
Y
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--
T
P
T
A
R
R
G
E
T
------------------
F
M
L
F
G
F
P
T
--
G
------------------------------------------------------------
28
HHSearch
46.77
16%
29
- C2 -
-
2E7Z
5
AHY_PELAE
A:
[2-678]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
V
C
-
Q
S
C
D
--
I
N
C
V
V
E
A
-
E
V
K
A----------------------------------------
D
G
-----------------------------
K
I
--
Q
T
---------
K
S
I
-------
S
------
E
P
H
P
T
T
P
-------
P
N
S
I
-
C
M
K
S
V
N
A
D
T
I
R
T
H
------
K
-----
D
R
-
V
L
Y
P
L
K
N
V
G
SKRGE---------------------------------
Q
R
W
E
R
I
S
W
D
Q
A
L
D
E
I
A
-----
E
K
L
K
K
I
I
A
K
Y
G
P
E
---
S
L
G
V
S
----
Q
----
T
E
I
N
Q
Q
S
E
Y
G
-
T
---
L
----
R
----
R
---
F
M
N
L
L
-
G
----
S
--
P
N
W
T
S
A
---------------------
M
Y
M
C
I
G
N
T
A
G
V
H
R
V
-
T
H
G
--------
S
Y
S
F
-
A
S
F
A
-
D
S
N
C
L
L
F
I
---------------
G
K
N
L
S
N
H
N
W
V
-
S
Q
--------
F
--
N
D
-------
L
----
K
---
A
A
L
----
K
----
R
---------------------------------
G
C
K
L
I
V
L
D
P
R
---------------
R
T
K
V
A
E
------
M
-
A
D
--------
I
W
L
P
L
R
Y
G
T
---------
D
A
A
L
F
L
G
M
I
N
V
I
I
N
E
Q
LYD
K
E
F
V
E
N
WCVG
F
E
E
L
K
E
R
V
Q
EYP-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
V
A
E
I
T
G
-----
C
D
A
G
E
I
R
K
A
A
V
M
F
A
T
E
-----
S
------
P
-------------
A
S
I
P
--
W
A
V
S
T
D
-
M
-
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----
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N
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C
S
A
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R
A
Q
C
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L
R
A
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V
G
SFV-
N
G
A
E
I
-----------
L
G
A
PHSDLVP
I
S
------------
K
I
Q
MHEAL-----
P
E
-----
E
K
---
K
K
-
L
----------------
Q
-----------------------------------------------
L
-----------------------------------------------
G
---------
T
ETYPFLTYTGMSAL
E
E
P
S
E
R
V
YGVKYFHNMGAFM
A
------------------------------------
N
------------------------
P
--------------------------
T
--------------------------
A
L
F
T
A
-------------
M
----
A
------------
T
------------
E
KP
Y
P
V
K
A
F
F
A
L
A
S
-
N
A
L
M
------
G
Y
A
N
Q
Q
N
----
A
------------------------------
L
------------------------------
K
G
L
-
M
----
N
Q
-
D
-
L
V
V
C
Y
D
Q
F
M
T
P
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T
A
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L
A
D
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L
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V
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N
---
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-
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---
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--
I
P
F
G
N
T
S
Q
Q
V
V
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-
G
----
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A
K
D
E
Y
Y
F
I
R
E
L
A
V
R
M
G
L
E
--------------
E
H-------------
F
---
P
-----------
W
-----
K
------
D
--------------------
R
L
E
L
I
N
----------------
Y
R
-----------------------------------
I
S
P
-------------
T
-----
G
M
E
-----------
W
----
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---
E
Y
Q
K
Q
--------
Y
T
--
Y
-----------
M
-----------------------------------------------------------------------------
S
K
L
P
D
Y
-----------------------
F
-
G
-
P
E
G
------------
V
G
V
A
----
T
P
---------
S
G
K
V
--
E
L
Y
S
S
--
V
F
E
-----
K
L
-----------------------
G
Y
D
P
L
P
Y
-
Y
H
E
P
L
Q
T
-
E
I
--------------------
S
D
P
E
L
A
K
E
Y
P
L
I
L
----------------------------------------------
F
A
G
L
--
R
E-
D
S
N
F
Q
S
C
Y
H
Q
-
P
-
G
I
L
R
D
A
-
E
---
P
D
P
------
V
A
L
L
H
P
K
T
A
Q
S
L
G
L
P
S
G
E
W
I
W
V
E
T
T
H
G
R
L
K
--
L
L
L
K
H
--
D
G
A
Q
P
E
G
T
I
------------------
R
I
P
H
G
R
W
C
--
P
------------------------------------------------------------
35
HHSearch
46.24
15%
29
- C2 -
-
3EGW
3
NARG_ECOLI
A:
[43-1166]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
V
R
S
T
H
G
V
N
C
T
--
G
S
C
S
W
K
I
-
Y
V
K
-----------------------------------------
N
G
-----------------------------
L
V
--
T
W
---------
E
T
Q
Q
TDYPRT
R
------
P
D
L
P
-
N
H
-------
E
P
R
G
-
C
P
R
G
A
S
Y
S
W
Y
L
Y
S
------
A
-----
N
R
-
L
K
Y
P
M
M
R
K
R
L
M
K
M
W
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K
A
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SD
P
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A
S
I
I
E
D
A
D
K
A
K
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A
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G
G
F
V
R
S
S
W
Q
E
V
N
E
L
I
A
-----
A
S
N
V
Y
T
I
K
N
Y
G
P
D
---
R
V
A
G
F
----
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----
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P
A
M
S
M
V
S
Y
-
A
---
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G
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Y
L
----
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---
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I
----
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----
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--
T
C
L
S
F
Y
---------------------
D
W
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L
P
P
A
-
S
P
-
Q
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T
W
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--
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--
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P
E
S
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A
D
W
Y
-
N
S
S
Y
I
I
A
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---------------
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N
V
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T
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D
---------
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--
H
F
-------
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----
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---
E
V
R
----
Y
----
K
---------------------------------
G
T
K
T
V
A
V
T
P
D
---------------
Y
A
E
I
A
K
------
L
-
C
D
--------
L
W
L
A
P
K
Q
G
T
---------
D
A
A
M
A
L
A
M
G
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V
M
L
R
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F
HLDNPS
Q
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F
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V
R
R
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TDMP
M
L
V
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DG
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AGRMLRAADLVAALGQENNPEW
K
T
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A
F
N
TNG
E
M
V
A
P
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GS
I
G
F
R
W
GEKGKWNLEQRDGKTG
E
E
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S
LLGSQD
E
I
A
E
V
G
F
P
Y
FGGDGTEH
F
N
K
V
E
L
E
N
V
L
L
H
K
L
P
V
K
R
L
Q
L
ADG
S
T
A
L
V
T
T
V
Y
D
L
T
L
A
N
Y
GLERGLNDVNCATSYDDVKAYT
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
A
E
Q
I
T
G
-----
V
S
R
S
Q
I
I
R
I
A
R
E
F
A
D
N
A
D
K
T
H
G
------
R
-------------
S
M
I
I
--
V
G
A
G
L
N
-
H
-
W
----
Y
H
L
D
M
N
Y
R
G
L
I
N
M
L
I
F
C
G
CVGQ
S
G
G
G
W
-----------
A
H
--------
Y
V
------------
G
Q
-----------
E
K
-----
L
R
---
P
Q
-
T
GW
Q
P
L
A
F
ALDWQRP
A
R
H
M
N
S
T
S
Y
F
Y
N
HSSQWRYETVTAEELLSPMADKSR
Y
T
G
H
L
I
D
F
N
V
R
A
E
R
M
-----------------------------------------------
G
---------
W
----------------------------------
L
------------------------------------
P
------------------------
S
A
PQLGTNPLT
I
A
G
E
A
E
K
A
GMN
P
V
D
Y
T
V
--------------------------
K
S
----------------
L
----
K
E
GSIRFAAEQPE
N
------------
G
KN-
H
P
R
N
L
F
I
W
R
S
-
N
L
L
G
------
S
S
G
K
G
H
E
F
---
M
L
K
YLLGTEHGIQGKDLGQQGGVKPEE
V
D
W
Q
D
------------------------------
N
G
L
E
G
----
K
L
-
D
-
L
V
V
T
L
D
F
R
L
S
S
-
T
C
-
L
Y
S
D
I
I
L
P
T
A
-
T
W
Y
E
K
D
D
M
N
-
T
-
S
---
D
M
H
---
P
--
F
--
I
H
P
L
S
A
A
V
D
P
A
-
W
----
E
A
K
S
D
W
E
I
Y
K
A
I
A
K
K
F
S
E
V
--------------
C
--------------
V
GHL
G
K
E
T
D
I
V
T
L
P
IQ
H
-----
D
------
S
--------------------
A
A
E
L
A
Q
----------------
P
L
D
V
K
D
WKKGECDLIPGKTA
P
H
I
M
V
V
E
R
DYPA
T
Y
E
R
F
T
S
I
G
P
L
M
E
K
I
GNG
G
--
K
-----
G
I
A
W
-
N
---
T
Q
S
-
E
M
----
D
---
L
L
R
K
L
--------
N
Y
--
T
KAEGPAKGQPM
L
NT
A
I
D
A
A
E
M
I
L
T
L
APETN
G
Q
V
A
V
K
A
W
A
A
L
S
E
F
T
---------
G
R
-
D
HTHLALNKED
E
K
I
R
F
R
D
I
Q
A
Q
P
R
K
I
I
---
S
S
P
T
W
S
G
L
E
-----
D
EHV
S
Y
N
-----
A
-
G
Y
T
N
-
V
-
H
E
L
------------
I
P
W
R
----
T
L
---------
S
G
R
Q
--
Q
L
Y
Q
D
H
Q
W
M
R
-----
D
F
--------------
G
----------
E
S
L
L
V
-
Y
R
P
P
I
D
T
R
S
V
---------------
K
E
V
I
G
Q
K
S
N
G
N
Q
E
K
A
L
N
F
----------------------------------------------
L
T
P
H
--
Q
--
K
W
G
I
H
S
T
Y
S
D
-
N
-
L
L
M
L
T
L
G
R
---
G
G
P
------
V
V
W
L
S
E
A
D
A
K
D
L
G
I
A
D
N
D
W
I
E
V
F
N
S
N
G
A
L
T
--
A
R
A
V
V
--
S
Q
R
V
P
A
G
M
T
------------------
M
M
Y
H
A
Q
E
----------------------------------------------------------------
47
HHSearch
44.13
18%
6
- C2 -
-
5T5I
-
?
J:
[3-428]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
K
N
V
V
C
-
P
F
C
G
--
T
L
C
D
D
I
I
C
K
V
E
-----------------------------------------
G
N
-----------------------------
E
I
--
V
G
----------------------------------------
T
I
N
A
-
C
R
I
G
H
S
K
F
V
H
A
E
G
------
A
-----
M
R
-
Y
K
K
P
L
I
R
K
N
--------------------------------------
G
E
F
V
E
V
S
Y
D
E
A
I
D
KA
A
-----
K
I
L
A
E
----
S
K
R
P
----
L
M
Y
-----
G
----
W
S
C
T
E
C
E
A
Q
A
-
V
---
G
----
V
----
E
---
L
A
----
E
----
E
AG
A
V
I
D
N
T
---------------------
A
S
V
C
H
G
P
S
V
L
A
L
-
Q
-
D
V
G
--
Y
--
P
--
I
C
T
F
-
G
E
V
K
N
R
A
D
V
V
V
Y
W
---------------
G
C
N
P
M
H
A
H
P
R
-
H
---------
M
--
S
R
NVFARGF
F
----
R
---
E
R
G
----
R
----
S
---------------------------------
D
R
T
L
I
V
V
D
P
R
---------------
K
T
D
S
A
K
------
L
-
A
D
--------
I
H
L
Q
L
D
F
D
R
---------
D
Y
E
L
L
D
A
M
R
A
C
L
L
G
H
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
LY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
V
---
A
G
-----
V
P
R
E
Q
I
E
E
A
V
E
V
L
K
N
A
-----
Q
------
F
-------------
G
I
L
F
--
F
G
M
G
I
T
-
H
-
S
----
R
GKHR
N
I
D
T
A
I
M
M
V
Q
D
L
N
DY--
A
K
W
T
L
-----------
I
P
--------
M
R
------------
G
H
-----------
Y
N
-----
V
T
---
G
F
-
N
----------------
Q
-----------------------------------------------
V
-----------------------------------------------
C
---------
T
----------------------------------
W
------------------------------------
E
SGYPYCVDFSGGEPRYNPGETG--
A
--------------------------
N
--------------------------
D
-----------------
L
----
L
------------
Q
N-----------
R
---
E
A
D
A
M
M
V
I
-
A
S
D
P
G
A
------
H
F
P
Q
R
------
A
------------------------------
L
------------------------------
E
R
M
-
A
----
E
I
-
P
--
V
I
A
I
E
P
H
R
T
P
-
T
T
-
E
M
A
D
I
I
I
P
P
A
I
V
G
M
E
A
E
G
T
A
-
Y
-
R
---
M
-
E
---
G
--
V
--
P
I
R
M
K
K
V
V
D
S
-------
D
L
L
S
D
R
E
I
L
E
R
L
L
E
K
V
R
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
44.13
14%
21
- C2 -
-
1TMO
3
TORA_SHEMA
A:
[36-760]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
---
D
E
W
-------
L
--------------
T
T
G
-
S
H
F
-----
G
A
F
K
M
-
K
R
K
-----------------------------------------
N
G
-----------------------------
V
I
--
A
E
---------
V
K
P
-------
F
------
D
L
D
K
-
Y
P
-------
T
D
M
I
N
G
I
R
-----
G
M
V
Y
N
------
P
-----
S
R
-
V
R
Y
P
M
V
R
L
D
F
L
L
KGHKSNTHQRGD-----------------------
F
R
F
V
R
V
T
W
D
K
A
L
T
L
F
K
-----
H
S
L
D
E
V
Q
T
Q
Y
G
P
S
---
G
L
H
A
GQ---
T
----
G
W
R
A
T
G
Q
L
H
S
-
S
T
S
H
M
----
Q
----
R
---
A
V
----
G
----
M
H
-
G
N
Y
V
K
K
I
G
D
Y
S
T
--------------
G
A
G
Q
T
I
L
P
Y
V
L
G
S
-
T
E
V
Y
A
--
Q
-----
G
T
S
W
P
L
I
L
E
-
H
S
D
T
I
V
L
W
---------------
S
N
D
P
Y
K
N
L
Q
V
-
G
WNAETH
E
S
F
A
Y
L
A
Q
-------
L
----
K
---
E
K
V
----
K
Q
---
G
---------------------------------
K
I
R
V
I
S
I
D
P
V
---------------
V
T
K
T
Q
A
------
Y
L
G
C
--------
E
Q
L
Y
V
N
P
Q
T
---------
D
V
T
L
M
L
A
I
A
H
E
M
I
S
K
K
LYD
D
K
F
I
Q
G
YSLG
F
E
E
F
V
P
Y
V
M
GTKDGVAKT-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
A
API
C
G
-----
V
E
A
H
V
I
R
D
L
A
K
T
L
V
K
G
------------
R
-------------
T
Q
F
M
--
M
G
W
C
I
Q
-
R
-
Q
----
Q
H
G
E
Q
P
Y
W
M
A
A
V
L
A
T
M
I
G
QIGL
P
G
G
G
I
-----------
S
Y
--------
G
-------------
H
H
-----------
Y
S
SIGVP
S
S
---
G
A
-
A
----------------
A
-----------------------------------------------
P
-----------------------------------------------
G
---------
A
----------------------------------
F
------------------------------------
P
RNLDENQKPLFDSSDFKGASSTIP
V
AR
W
-----------------------
I
D
-------------------------
A
-----------------
I
----
L
------------
E
PG
K
T
I
D
A
NG
S
K
V
V
Y
P
-
D
I
K
M
M
I
F
S
G
N
-
N
P
W
N
------
H
H
Q
D
R
N
R
----
M
------------------------------
K
------------------------------
Q
A
F
-
H
----
K
L
-
E
-
C
V
V
T
V
D
V
N
W
T
A
-
T
C
-
R
F
S
D
I
V
L
P
A
C
-
T
T
Y
E
R
N
D
I
D
-
V
-
Y
G
AY
A
-
N
---
R
--
G
--
I
L
A
M
Q
K
M
V
E
P
L
-
F
----
D
S
L
S
D
F
E
I
F
T
R
F
A
A
V
L
G
K
E
--------------
K
E
-------------
Y
---
T
R----------
N
-----
M
G
E
M
E
--
W
--------------------
L
E
T
L
Y
N
----------------
E
C
-----------------------------------
K
A
A
N
A
G
-------
K
F
-
E
-----
M
P
D
-----------
F
----
A
---
T
F
W
K
Q
--------
G
Y
--
V
-----------
H
--------------------------------
F
---------
G
--------------------------------
D
G
E
V
W
T
R
H
A
-----
D
-----
F
-----
R
----
N
-
D
-
P
E
I
------------
N
P
L
G
----
T
P
---------
S
G
L
I
--
E
I
F
S
R
--
K
I
D
-----
Q
F
G
-----------------
Y
D
---
D
C
K
G
H
P
T
-
W
M
E
K
T
E
R
----------------------
S
H
G
G
P
G
S
D
K
H
P
I
W
L
----------------------------------------------
Q
S
C
H
--
P
--
D
K
R
L
H
S
Q
M
C
E
-
S
-
R
E
Y
R
E
T
-
Y
AVN
G
R
E
------
P
V
Y
I
S
P
V
D
A
K
A
R
G
I
K
D
G
D
I
V
R
V
F
N
D
R
G
Q
L
L
--
A
G
A
V
V
--
S
D
N
F
P
K
G
I
V
------------------
R
I
H
E
G
A
W
Y
--
G
------------------------------------------------------------
46
HHSearch
43.98
18%
6
- C2 -
-
5T5I
3
?
B:
[3-428]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
K
N
V
V
C
-
P
F
C
G
--
T
L
C
D
D
I
I
C
K
V
E
-----------------------------------------
G
N
-----------------------------
E
I
--
V
G
----------------------------------------
T
I
N
A
-
C
R
I
G
H
S
K
F
V
H
A
E
G
------
A
-----
M
R
-
Y
K
K
P
L
I
R
K
N
--------------------------------------
G
E
F
V
E
V
S
Y
D
E
A
I
D
K
A
A
-----
K
I
L
A
E
----
S
K
R
P
----
L
M
Y
-----
G
----
W
S
C
T
E
C
E
A
Q
A
-
V
---
G
----
V
----
E
---
L
A
----
E
----
E
A
G
A
V
I
D
N
T
---------------------
A
S
V
C
H
G
P
S
V
L
A
L
-
Q
-
D
V
G
--
Y
--
P
--
I
C
T
F
-
G
E
V
K
N
R
A
D
V
V
V
Y
W
---------------
G
C
N
P
M
H
A
H
P
R
-
H
---------
M
--
S
R
NVFARGF
F
----
R
---
E
R
G
----
R
----
S
---------------------------------
D
R
T
L
I
V
V
D
P
R
---------------
K
T
D
S
A
K
------
L
-
A
D
--------
I
H
L
Q
L
D
F
D
R
---------
D
Y
E
L
L
D
A
M
R
A
C
L
L
G
H
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
LY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
V
---
A
G
-----
V
P
R
E
Q
I
E
E
A
V
E
V
L
K
N
A
-----
Q
------
F
-------------
G
I
L
F
--
F
G
M
G
I
T
-
H
-
S
----
R
G
K
H
R
N
I
D
T
A
I
M
M
V
Q
D
L
N
DY--
A
K
W
T
L
-----------
I
P
--------
M
R
------------
G
H
-----------
Y
N
-----
V
T
---
G
F
-
N
----------------
Q
-----------------------------------------------
V
-----------------------------------------------
C
---------
T
----------------------------------
W
------------------------------------
E
SGYPYCVDFSGGE
P
R
Y
N
P
GETG--
A
--------------------------
N
--------------------------
D
-----------------
L
----
L
------------
Q
N
-----------
R
---
E
A
D
A
M
M
V
I
-
A
S
D
P
G
A
------
H
F
P
Q
R
------
A
------------------------------
L
------------------------------
E
R
M
-
A
----
E
I
-
P
--
V
I
A
I
E
P
H
R
T
P
-
T
T
-
E
M
A
D
I
I
I
P
P
A
I
V
G
M
E
A
E
G
T
A
-
Y
-
R
---
M
-
E
---
G
--
V
--
P
I
R
M
K
K
V
V
D
S
-------
D
L
L
S
D
R
E
I
L
E
R
L
L
E
K
V
R
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
40.33
15%
29
- C2 -
-
1Q16
4
NARG_ECOLI
A:
[2-1245]
S
K
F
L
D
R
F
R
Y
FKQ
K
G
E
T
F
A
D
G
H
G
Q
L
L
N
T
N
R
D
W
E
D
G
Y
R
Q
R
W
Q
H
D
K
I
V
R
S
T
H
-
G
V
N
-
C
T
G
S
C
S
W
K
I
Y
V
K
NG
L
V
T
W
E
T
Q
---
Q
T
D
Y
P
R
T
RPDLPNHEPRG
C
P
R
G
A
S
Y
S
W
Y
L
Y
S
A
N
R
L
K
Y
P
M
M
R
K
R
L
M
K
M
W
R
E
A
K
A
L
H
S
D
P
V
E
A
W
A
S
I
I
E
D
A
D
K
A
K
S
F
K
Q
A
R
G
R
G
G
F
V
-----------
R
S
S
W
Q
E
V
-
N
E
L
I
A
A
S
N
V
Y
T
I
K
N
YGPDR
V
A
G
F
S
P
IPAM
S
M
V
S
Y
A
S
G
A
R
Y
L
S
L
I
G
G
T
C
L
S
F
Y
DWYCDL
P
P
A
S
P
Q
T
W
G
E
Q
T
D
V
P
E
S
A
D
W
Y
N
SS
Y
I
I
AWGSNV
P
Q
T
R
T
P
D
A
H
F
F
T
E
V
R
Y
K
G
T
K
T
V
A
V
T
P
D
Y
A
E
I
A
K
L
C
D
L
W
L
A
P
KQGT
D
A
---------
A
M
A
L
A
M
G
-
H
V
M
L
--
R
E
F
H
L
D
N
-
P
S
Q
-----------------------------------------
Y
------------------------------
F
T
--
D
Y
---------
V
R
R
-------
Y
------
T
D
M
P
-
M
L
-------
V
M
L
E
-
E
R
D
G
Y
Y
A
A
G
R
M
L
R
------
A
-----
A
D
L
V
D
A
L
G
Q
E
N
N
--------------------------------------
P
E
W
K
T
V
A
F
N
T
N
G
E
--
M
V
A
P
N
G
S
I
G
F
R
----
W
G
E
K
GKW
N
L
E
Q
-----
R
----
D
G
K
T
G
E
E
T
E
L
-
Q
---
L
---------
S
---
L
L
----
G
----
S
--
Q
D
E
I
A
E
---
V
G
F
P
Y
FGGDGTEH
F
N
K
V
E
L
E
N
V
L
L
H
K
L
P
V
K
-
R
-
L
Q
L
--
A
--
D
--
G
S
T
A
-
L
V
T
T
-
V
Y
D
L
T
L
A
N
Y
GLERGLNDVNCATS
Y
D
D
V
K
A
Y
T
P
A
-
W
---------
A
--
E
Q
-------
I
TGVS
R
---
S
Q
I
----
I
R
---
I
A
R
E
F
A
D
N
A
D
K
T
H
G
R
S
M
I
I
V
G
A
G
L
N
HWYH
L
D
M
N
Y
R
G
L
I
N
M
L
I
F
C
GCVGQSGG
G
W
A
H
Y
V
G
Q
E
K
L
R
P
------
Q
-
T
G
--------
W
Q
P
L
A
F
A
L
D
WQRP
A
R
H
M
N
S
T
S
Y
F
Y
N
H
S
S
Q
W
R
Y
E
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
E
---
E
L
LSPMA
D
K
S
R
Y
T
G
H
L
I
D
F
N
V
R
A
-----
E
------
R
M
GW
L
P
S
A
PQLGTN
P
L
T
I
--
A
G
E
A
E
K
-
A
G
M
----
N
----
P
V
D
Y
T
V
K
S
L
K
E
G
S
----
I
R
F
A
A
EQPENGKNHPR
N
L
--------
F
I
------------
W
R
-----------
S
N
-----
L
L
---
G
S
-
S
----------------
G
-----------------------------------------------
K
-----------------------------------------------
G
---------
H
----------------------------------
E
------------------------------------
F
------------------------
M
--------------------------
L
--------------------------
K
-----------------
Y
----
L
------------
L
------------
G
---
T
E
H
G
I
Q
G
K
-
D
-
L
G
Q
Q
------
G
G
V
K
P
E
E
----
V
D
W
Q
D--------------------------
N
------------------------------
G
L
E
-
G
----
K
L
-
D
-
L
V
V
T
L
D
F
R
L
S
S
-
T
C
-
L
Y
S
D
I
I
L
P
T
A
-
T
W
Y
E
K
D
D
M
N
-
T
-
S
---
D
-----------
M
H
P
F
I
H
P
L
S
A
A
V
-
D
P
A
W
E
A
K
S
D
W
E
I
Y
K
A
I
A
K
K
F
S
E
V
C
-------------
V
--------------
G
---
H
-----------
L
-----
G
------
K
--------------------
E
T
D
I
V
T
----------------
L
P
-----------------------------------
I
Q
H
D
S
A
-------
A
--
E
LAQPL
D
V
K
D
-
W
---
K
K
G
E
C
D
L
I
P
G
K
TA
P
H
I
M
V
V
--------
E
R
--
D
-----------
Y
--------------------------------
P
A
T
Y
E
R
F
T
S
I
G
P
-
L
-------------
M
E
K
--------
I
G
---
N
G
G
K
G
I
A
W
N
-----
T
-----
Q
-----
S
-
E
M
D
L
-
L
-
R
K
L
------------
N
Y
T
K
----
A
E
GPAKGQPML
N
T
A
I
--
D
A
A
E
M
--
I
L
T
L
APET
N
G
Q
V
A
V
K
A
W
A
A
L
S
E
F
T
G
R
D
H
T
H
LAL
N
K
E
D
E
K
I
R
F
R
D
I
Q
A
Q
P
R
K
I
I
SSPTWSGLEDEHV
S
Y
N
-
A
G
Y
T
N
V
H
E
L
I
P
W
R
T
LSGRQQLYQDH
Q
W
M
R
D
F
GES
L
L
V
Y
R
P
PIDTRSVKEVIGQKSNG
N
Q
E
K
A
L
N
--
F
--
L
T
P
H
Q
K
W
G
I
H
-
S
-
T
Y
S
D
N
L
-
L
---
M
L
T
L
G
RG
G
P
V
V
W
L
S
E
A
D
A
K
D
L
G
I
A
D
N
D
W
I
E
V
F
N
S
N
G
A
L
T
--
A
R
A
V
V
--
S
Q
R
V
P
A
G
M
T
MMYHAQERIVNLPGSEIT
Q
Q
R
G
G
I
H
N
--
S
--
V
T
R
I
T
P
K
P
T
H
M
I
G
G
Y
AHLAYGFNYYGTVGSNRD
E
F
V
V
V
R
K
M
K
N
IDWLDGEGN
D
Q
V
Q
E
S
52
Fugue
38.03
19%
-27
- C3 -
-
1FEH
2
PHF1_CLOPA
A:
[1-126]
------------
M
K
T
I
I
I
N
G
V
Q
F
N
T
D
E
D
T
T
I
L
K
F
A
R
D
N
-
N
I
D
I
S
A
L
C
F
L
N
N
C
N
N
D
I
N
K
C
E
I
C
T
V
E
V
--------
E
---
G
T
G
L
V
T
A
-----------
C
D
T
L
I
E
D
G
M
I
I
N
T
N
S
D
-
A
V
N
E
K
I
K
S
R
I
S
Q
L
L
D
I
---
H
E
F
K
C
G
P
C
N
R
R
E
N
C
E
F
L
K
L
V
I
K
Y
K
A
R
A
S
K
P
F
-----------
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------