@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VU96: (2017-12-17 )
MEKLQQYAIGQRWLSDTETELGLGVLIDVDERSVSILFPKSDETRVYARNNAPLSRIIFNTNDEVQDQEGQKWIVESVEDRHGVLRYNVLRTLENGEQERKALNETRIGAQIQLSKPLDRLLASQIDYKEWYDLRIEAMLMQAQMQTSPLCGLVGARVGLIPHQLYIAHEVGKRFAPRVLLADEVGLGKTIEAGLIIHQQLKTGRSERILILVPDSLQYQWMIEMRRRFNLQFSLFDLTRTASIKEHDPELNPFLTEQCIIASVDLMVDHDDLREQALEVGFDLLVVDEAHHLMWSEEEGGNDRYDLVEELAENTAGVLLLTATPEQLGVESHFARLRLLDPQRFSSLERFLDEEAQYQQTAQVAEVLMSDEPLTQEHLTALEGLLGHSIEDQPEQRFRAIHELLDRHGTGRILFRNTREAIQGFPGRDCQPAPLPAPADWSKDGKLREQMWPEEAQIDGSWMQNDPRVPWLMEILRKELKHKKVLLIARSGPVVESLESALRLHAGIRTAMFHEGMSLLERDQAAAYFAEESYGAQILLCSEIGSEGRNFQFASDLILFDLPANPDVLEQRIGRLDRIGQENRIQIHVPYLMGTAQERMFRWYNEALNIFSNISPTAQTLQENFIVELKDCLLADQGQTFEDLLEEVNVQRQALEAELQAGRDRLLEYNSCRPIVAQEIVQALEDYDDNTTLPMFVKRFMSSTNIDFDEQSNGTVIIRPTDQMQVQGLALDEEGMTATFYRDQAQMREDAQYLTLEHPFIESVMEMIRTQSFGSTNVAVLKSNALKQGSVLLEVWFKVDVVAPKSLNLPSSLPKQLIRVLLSENGQDLSEKIDPTILKPYLHHLDGNSCRQVVKARREVIEERYKQALDIAKEGLPQLQQQAKEHYGNKWQYEIDRLTYLKQFNPSIRQDEIERLQKLQKEGLSLLDGLTVTPEAIQVLVVVKP
Atome Classification :
(20 SA)
.........10........20........30........40........50.-.......60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170..-------.....180.......190.----......200..-----..-----...210...-....220.......230...--.....------.240.....----..250......---.260.......270..---.....280........290.......300......-.-310-..-....--..320...--....330......-------.340-----......----.-.-.350.......---------------------360-------.----........370.......380..---....------------.------------390-..-----..-....400-------------------.........-410----------....-----..--..420--.-.---..-.----------..430.--.---.---.----...440.--------------...---.-.------.--------------..450.--------------...-----.----------------..460-......--...470.......480-..--.---..--....490.......500...--------------------------------------....510...--------....520.......530..-...-..540........550.......560......--------.570.......580.......590.......600.......610.......620.......630...-.-...640.......-----------650.......660.......670.......680.......690.......700.......710.......720.......-730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
K
L
Q
Q
Y
A
I
G
Q
R
WLSDTETELG
L
G
V
L
I
D
VDER
S
V
S
I
L
FPKSDE
T
R
V
Y
ARNNA-P
L
S
R
I
I
FNTNDEVQDQEG
Q
K
W
I
V
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S
V
E
DRH
G
V
L
R
Y
N
V
L
R
T
LEN
G
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Q
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K
A
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N
ETRIG
A
Q
I
Q
LSK
P
L
D
R
L
L
A
S
QI
D
Y
K
E
W
Y
D
L
R
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A
M
L
M
Q
A
QMQTSP
L
C
G
L
V
G
A
R
VGLI
P
H
Q
L
Y
I
A
H
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V
G
K
R-------FA
P
R
V
L
L
A
DEVGLGKT
I
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A
----
G
L
I
I
H
Q
Q
L
KTG-----RS-----
E
R
I
L
I
L
VPD-S
L
Q
Y
Q
W
M
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M
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RFN--
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S
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------TRTASIKEH----DPELN
P
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---
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H
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Y
Q
---------------------
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----
A
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V
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LMSDEPL
T
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L
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---
L
LGH------------S------------IE--D
Q
-----
P
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-
Q
R
F
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A
---------------------
I
H
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L
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DRHG-T-
G
----------
R
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--
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--------------
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V
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M
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A
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A
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-
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L
L
C
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N
F
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DLPA
N
P
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--------
L
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N
R
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P
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T
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N
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S
P
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LA-D-QGQ
T
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-----------
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P
I
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Q
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DYDDNT
T
L
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M
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STNIDFDEQSN
G
T
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RPTDQ
M
Q
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Q
G
L
-
A
LDEEG
M
T
A
T
F
Y
R
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Q
A
Q
M
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EDA
Q
Y
L
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LE
H
P
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M
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M
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RTQSFGST
N
V
A
V
L
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S
V
L
L
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V
W
F
K
V
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VVAPKSLNL
P
S
S
L
P
K
Q
L
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V
L
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Q
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L
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G
N
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R
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G
L
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LDGLTV
T
P
E
A
I
Q
V
L
V
V
VKP
31
HHSearch
79.83
43%
-17
- C1 -
-
3DMQ
-
RAPA_ECOLI
A:
[2-962]
-----
P
F
T
L
G
Q
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W
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G
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A
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---
L
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L
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K
L
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N
D
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L
N
M
L
G
E
---
M
I
G
E
------------
Q
DIEPLLQAANSD
S
E
--
D
A
-----
Q
S
-
A
R
Q
E
L
---------------------
V
S
M
L
M
D
R
H
G
-
T
-
S
----------
R
V
L
F
-----
R
N
--
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R
N
G
V
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K
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G
---
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P
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P
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------
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R
D
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L
Y
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--------------
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R
I
Y
Q
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G
----------------
D
N
A
---
T
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R
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--------------------------------------
E
G
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A
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M
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Y
N
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L
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N
G
N
N
L
A
A
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F
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N
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N
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H
T
G
S
K
L
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N
A
V
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Q
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V
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A
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L
Q
L
G
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A
Q
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A
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A
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A
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D
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L
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A
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S
R
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L
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N
P
N
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R
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D
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Q
Q
V
M
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S
L
D
Q
A
G
W
R
L
D
A
L
R
L
------
2
PsiBlast_PDB
78.09
41%
-13
- C1 -
-
3DMQ
-
RAPA_ECOLI
A:
[3-962]
------
F
T
L
G
Q
R
W
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T
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M
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Q
Q
L
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L
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M
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L
A
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L
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N
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---
M
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QDIEPLLQAANS
D
------------
S
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--
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A
-----
Q
S
-
A
R
Q
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L
---------------------
V
S
M
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M
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-
T
-
S
----------
R
V
L
F
-----
R
N
--
T
R
N
G
V
--
K
-
G
---
F
P
-
K
----------
R
E
L
H
T
I
--
K
---
L
---
P
----
L
P
T
Q
--
Y
Q
T
A
I
K
V
S
G
I
M
G
ARK
S
A
E
---
D
-
R
------
A
--------------
R
D
M
L
Y
P
--------------
E
R
I
Y
Q
---
E
----------------
F
E
G
DNA
T
W
W
N
F
D
--
P
R
V
E
W
L
M
G
Y
L
T
S
H
----
R
S
--
Q
---
K
V
--
L
V
I
C
A
K
A
A
T
A
L
Q
L
E
Q
V
L
R
E
R
--------------------------------------
E
G
I
R
A
A
V
F
H
E
--------
G
M
S
I
I
E
R
D
R
A
A
A
W
F
A
E
E
D
T
-
G
A
Q
-
V
L
L
C
-
S
E
I
G
S
E
G
R
N
F
Q
F
A
S
H
M
V
M
F
D
L
P
F
N
P
D
L
--------
L
E
Q
R
I
G
R
L
D
R
I
G
Q
A
H
D
I
Q
I
H
V
P
Y
L
E
K
T
A
Q
S
V
L
V
R
W
Y
H
E
G
L
D
A
F
E
H
T
C
P
T
G
R
T
I
Y
D
S
V
Y
N
D
L
I
N
Y
L
A
S
P
D
-
Q
T
E
G
F
D
D
L
I
K
N
C
R
-----------
E
Q
H
E
A
L
K
A
Q
L
E
Q
G
R
D
R
L
L
E
I
H
S
N
G
G
E
K
A
Q
A
L
A
E
S
I
E
E
Q
D
D
D
T
N
L
I
A
F
A
M
N
L
F
D
I
I
G
I
N
Q
D
D
R
G
D
N
M
I
V
L
T
P
S
D
H
M
L
V
P
D
F
P
G
L
S
E
D
G
I
T
I
T
F
D
R
E
V
A
L
A
R
E
D
A
Q
F
I
T
W
E
H
P
L
I
R
N
G
L
D
L
I
L
S
G
D
T
G
S
S
T
I
S
L
L
K
N
K
A
L
P
V
G
T
L
L
V
E
L
I
Y
V
V
E
A
Q
A
P
K
Q
L
Q
L
N
R
F
L
P
P
T
P
V
R
M
L
L
D
K
N
G
N
N
L
A
A
Q
V
E
F
E
T
F
N
R
Q
L
N
A
V
N
R
H
T
G
S
K
L
V
N
A
V
Q
Q
D
V
H
A
I
L
Q
L
G
E
A
Q
I
E
K
S
A
R
A
L
I
D
A
A
R
N
E
A
D
E
K
L
S
A
E
L
S
R
L
E
A
L
R
A
V
N
P
N
I
R
D
D
E
L
T
A
I
E
S
N
R
Q
Q
V
M
E
S
L
D
Q
A
G
W
R
L
D
A
L
R
L
------
1
PsiBlast_PDB
77.67
42%
-14
- C1 -
-
4S20
-
RAPA_ECOLI
K:
[9-968]
------
F
T
L
G
Q
R
W
I
S
D
T
E
S
E
L
G
L
G
T
V
V
A
V
D
A
R
T
V
T
L
L
F
P
S
T
G
E
N
R
L
Y
A
R
S
D
S
-
P
V
T
R
V
M
F
N
P
G
D
T
I
T
S
H
D
G
W
Q
M
Q
V
E
E
V
K
E
E
N
G
L
L
T
Y
--
I
G
T
R
L
D
T
E
E
S
G
V
A
L
R
E
V
F
L
D
S
K
L
V
F
S
K
P
Q
D
R
L
F
A
G
Q
I
D
R
M
D
R
F
A
L
R
Y
R
A
R
K
Y
S
S
E
Q
F
R
M
P
Y
S
G
L
R
G
Q
R
T
S
L
I
P
H
Q
L
N
I
A
H
D
V
G
R
R
-------
H
A
P
R
V
L
L
A
D
E
V
G
L
G
K
T
I
E
A
----
G
M
I
L
H
Q
Q
L
L
S
G
-----
A
A
-----
E
R
V
L
I
I
V
P
E
-
T
L
Q
H
Q
W
L
V
E
M
L
R
R
F
N
--
L
R
F
--
A
L
F
D
D
------
E
R
Y
A
E
-
A
Q
H
----
D
A
-
Y
N
P
F
D
T
E
Q
---
L
V
I
C
S
L
D
F
A
R
R
S
K
Q
R
L
---
E
H
L
C
E
A
E
-
W
D
L
L
V
V
D
E
A
H
H
L
V
W
S
E
D
A
P
S
R
E
-
Y
Q
A
I
-
E
-
Q
L
--
A
E
-
H
V
P
G
--
V
L
L
L
T
A
T
P
--
E
Q
L
G
M
E
S
H
F
A
R
L
R
-------
L
L
-------
D
P
N
R
F
H
----
D
-
F
-
A
Q
F
V
E
E
Q
K
N
Y
C
---------------------
P
---------
V
----
A
D
A
V
A
M
L
L
A
G
N
K
L
S
N
D
E
L
N
M
L
G
E
---
M
I
G
E
QDIEPLLQAANS
D
------------
S
E
--
D
A
-----
Q
S
-
A
R
Q
E
L
---------------------
V
S
M
L
M
D
R
H
G
-
T
-
S
----------
R
V
L
F
-----
R
N
--
T
R
N
G
V
--
K
-
G
---
F
P
-
K
----------
R
E
L
H
T
I
--
K
---
L
---
P
----
L
P
T
Q
--
Y
QTAIKVSGIMGARK
S
A
E
---
D
-
R
------
A
--------------
R
D
M
L
Y
P
--------------
E
R
I
YQ---
E
----------------
F
E
G
DNA
T
W
W
N
F
D
--
P
R
V
E
W
L
M
G
Y
L
T
S
H
----
R
S
--
Q
---
K
V
--
L
V
I
C
A
K
A
A
T
A
L
Q
L
E
Q
V
L
R
E
R
--------------------------------------
E
G
I
R
A
A
V
F
H
E
--------
G
M
S
I
I
E
R
D
R
A
A
A
W
F
A
E
E
D
T
-
G
A
Q
-
V
L
L
C
-
S
E
I
G
S
E
G
R
N
F
Q
F
A
S
H
M
V
M
F
D
L
P
F
N
P
D
L
--------
L
E
Q
R
I
G
R
L
D
R
I
G
Q
A
H
D
I
Q
I
H
V
P
Y
L
E
K
T
A
Q
S
V
L
V
R
W
Y
H
E
G
L
D
A
F
E
H
T
C
P
T
G
R
T
I
Y
D
S
V
Y
N
D
L
I
N
Y
L
A
S
P
D
-
Q
T
E
G
F
D
D
L
I
K
N
C
R
-----------
E
Q
H
E
A
L
K
A
Q
L
E
Q
G
R
D
R
L
L
E
I
H
S
N
G
G
E
K
A
Q
A
L
A
E
S
I
E
E
Q
D
D
D
T
N
L
I
A
F
A
M
N
L
F
D
I
I
G
I
N
Q
D
D
R
G
D
N
M
I
V
L
T
P
S
D
H
M
L
V
P
D
F
P
G
L
S
E
D
G
I
T
I
T
F
D
R
E
V
A
L
A
R
E
D
A
Q
F
I
T
W
E
H
P
L
I
R
N
G
L
D
L
I
L
S
G
D
T
G
S
S
T
I
S
L
L
K
N
K
A
L
P
V
G
T
L
L
V
E
L
I
Y
V
V
E
A
Q
A
P
K
Q
L
Q
L
N
R
F
L
P
P
T
P
V
R
M
L
L
D
K
N
G
N
N
L
A
A
Q
V
E
F
E
T
F
N
R
Q
L
N
A
V
N
R
H
T
G
S
K
L
V
N
A
V
Q
Q
D
V
H
A
I
L
Q
L
G
E
A
Q
I
E
K
S
A
R
A
L
I
D
A
A
R
N
E
A
D
E
K
L
S
A
E
L
S
R
L
E
A
L
R
A
V
N
P
N
I
R
D
D
E
L
T
A
I
E
S
N
R
Q
Q
V
M
E
S
L
D
Q
A
G
W
R
L
D
A
L
R
L
------
4
PsiBlast_PDB
46.48
25%
-164
- C1 -
-
2JGN
-
DDX3X_HUMAN
A:
[420-536]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
E
E
S
--
D
K
R
S
F
L
L
D
L
L
N
A
T
----
K
D
--
S
---
L
T
--
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
-
Y
H
--------------------------------------
E
G
Y
A
C
T
S
I
H
----------------
E
E
A
L
H
Q
F
--
R
S
G
-
K
S
P
-
I
L
V
A
-
T
A
------
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
E
--------
Y
V
H
R
I
G
R
T
G
R
V
G
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
46.47
25%
-161
- C1 -
-
5E7I
-
DDX3X_HUMAN
B:
[421-537]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
E
E
S
--
D
K
R
S
F
L
L
D
L
L
N
A
T
G
---
K
D
--
S
---
L
T
--
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
-
Y
H
--------------------------------------
E
G
Y
A
C
T
S
I
H
----------------
E
E
A
L
H
Q
F
--
R
S
G
-
K
S
P
-
I
L
V
A
-
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
E
--------
Y
V
H
R
I
G
R
T
G
R
V
G
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
42.83
25%
-141
- C1 -
-
2P6N
-
DDX41_HUMAN
A:
[414-525]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
K
E
E
--
A
K
M
V
Y
L
L
E
C
L
Q
K
-----
T
P
--
P
---
P
V
--
L
I
F
A
E
K
K
A
D
V
D
A
I
H
E
Y
L
L
L
K
---------------------------------------
G
V
E
A
V
A
I
H
G
--------
G
K
D
Q
E
E
R
T
K
A
I
E
A
F
R
E
G
K
---
K
D
-
V
L
V
A
-
T
D
V
A
S
K
G
L
D
F
P
A
I
Q
H
V
I
N
Y
D
M
P
E
E
I
E
N
--------
Y
V
H
R
I
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
42.36
25%
-139
- C1 -
-
5E7M
-
DDX3X_HUMAN
A:
[289-405]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
E
E
S
--
D
K
R
S
F
L
L
D
L
L
N
A
T
G
---
K
D
--
S
---
L
T
--
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
-
Y
H
--------------------------------------
E
G
Y
A
C
T
S
I
H
G
--------
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
--
R
S
G
-
K
S
P
-
I
L
V
A
-
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
E
--------
Y
V
H
R
I
G
R
T
G
R
V
G
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
41.28
25%
-132
- C1 -
-
5E7J
-
DDX3X_HUMAN
A:
[289-405]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
E
E
S
--
D
K
R
S
F
L
L
D
L
L
N
A
T
G
---
K
D
--
S
---
L
T
--
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
-
Y
H
--------------------------------------
E
G
Y
A
C
T
S
I
H
G
--------
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
--
R
S
G
-
K
S
P
-
I
L
V
A
-
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
E
--------
Y
V
H
R
I
G
R
T
G
R
V
G
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
41.10
25%
-137
- C1 -
-
4PXA
-
DDX3X_HUMAN
A:
[306-422]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
E
E
S
--
D
K
R
S
F
L
L
D
L
L
N
A
T
G
---
K
D
--
S
---
L
T
--
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
-
Y
H
--------------------------------------
E
G
Y
A
C
T
S
I
H
G
--------
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
--
R
S
G
-
K
S
P
-
I
L
V
A
-
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
E
--------
Y
V
H
R
I
G
R
T
G
R
V
G
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
38.76
16%
10
- C1 -
-
1Z3I
-
?
X:
[1-644]
------------------------------------
L
G
L
R
R
A
G
V
R
K
A
L
H
D
P
F
-
E
D
G
A
L
V
L
Y
E
P
P
A
--------------------------
I
S
A
H
D
L
I
K
A
D
K
E
K
L
P
V
H
V
V
V
D
P
V
L
S
K
V
L
R
------------------------
P
H
Q
R
E
G
V
K
F
L
W
D
C
V
T
G
R
R
I
E
N
------------------
S
Y
G
C
I
M
A
D
E
M
G
L
G
K
T
L
Q
C
----
I
T
L
I
W
T
L
L
K
Q
S
-----
P
D
CKPEI
D
K
V
I
V
V
S
P
S
-
S
L
V
R
N
W
Y
N
E
V
G
K
W
L
G
--
G
R
V
--
Q
P
V
A
I
DGGSKD
E
I
D
S
K
L
V
N
F
----
I
S
Q
Q
G
M
R
I
P
T
P
---
I
L
I
I
S
Y
E
T
F
R
L
H
---
A
---
E
V
L
H
K
G
K
-
V
G
L
V
I
C
D
E
G
H
R
L
K
-------
N
S
D
N
Q
T
Y
-
L
-
A
L
--
N
S
M
N
A
Q
R
--
R
V
L
I
S
G
T
P
--
I
Q
N
D
L
L
E
Y
F
S
L
V
H
-------
F
V
-------
N
S
G
I
L
G
----
T
-
A
-
Q
E
F
K
K
R
F
E
I
P
I
---------------------
L
---------
K
----
G
R
D
A
D
A
S
D
K
D
R
A
A
G
E
Q
K
L
Q
E
L
I
S
---
I
V
N
R
------------
C
------------
L
I
--
R
R
-----
T
S
-
D
I
L
S
K
YLPVKIEQVVCCNLTPLQKEL
Y
K
L
F
L
K
Q
A
K
-
P
-
V
----------
E
S
L
Q
TGKIS
V
S
--
S
L
S
S
I
--
T
-
S
---
L
K
-
K
----------
L
C
N
H
P
A
--
L
---
I
---
Y
----
E
K
C
L
--
T
--------------
G
E
E
---
G
F
D
------
G
--------------
A
L
D
L
F
P
--------------
Q
N
Y
-----
S
----------------
T
K
A
---
V
E
P
Q
L
S
--
G
K
M
L
V
L
D
Y
I
L
A
M
T
R
---
T
T
TS
D
---
K
V
--
V
L
V
S
N
Y
T
Q
T
L
D
L
F
E
K
L
C
R
N
R
---------------------------------------
R
Y
L
Y
V
R
L
D
G
--------
T
M
S
I
K
K
R
A
K
I
V
E
R
F
N
N
P
S
S
-
P
E
F
-
I
F
M
L
S
S
K
A
G
G
C
G
L
N
L
I
G
A
N
R
L
V
M
F
D
P
D
W
N
P
A
N
--------
D
E
Q
A
M
A
R
V
W
R
D
G
Q
K
K
T
C
Y
I
Y
R
L
L
S
T
G
T
I
E
E
K
I
L
Q
R
Q
A
H
K
K
A
L
S
S
C
V
V
D
E
E
Q
D
V
E
R
H
F
S
----------------------------------------------
L
G
E
L
R
E
L
F
S
L
N
E
K
T
L
S
D
T
H
D
R
F
R
C
R
R
C
V
N
G
R
Q
V
R
P
-------
P
P
D
D
S
D
C
T
C
D
L
S
N
W
H
H
C
A
D
K
R
G
L
R
D
P
V
L
-
Q
A
S
W
D
A
A
V
S
F
V
F
H
Q
R
S
H
E
D
Q
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
38.51
19%
6
- C1 -
-
1Z3I
-
?
X:
[52-552]
------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
K
V
L
R
P
H
Q
R
E
G
V
K
F
L
W
D
C
VTGRRIE
N
S
Y
G
C
I
M
A
D
E
M
G
L
G
K
T
L
Q
C
----
I
T
L
I
W
T
L
L
K
Q
S
PDCKP
E
I
-----
D
K
V
I
V
V
S
P
S
-
S
L
V
R
N
W
Y
N
E
V
G
K
W
L
G
--
G
R
V
QP
V
A
I
D
G
------
G
S
K
D
E
I
D
S
K
LVNF
I
S
Q
Q
G
M
R
I
P
T
P
---
I
L
I
I
S
Y
E
T
F
R
L
H
A
------
E
V
L
H
K
G
K
-
V
G
L
V
I
C
D
E
G
H
R
L
K
N
S
D
----
N
Q
T
Y
L
A
L
-
N
-
S
M
-----
N
A
Q
R
--
R
V
L
I
S
G
T
P
--
I
Q
N
D
L
L
E
Y
F
S
L
V
H
-------
F
V
-------
N
S
G
I
L
G
----
T
-
A
-
Q
E
F
K
K
R
F
E
I
P
I
LKGRDADASDKDRAAGEQKLQ
E
---------
L
----
I
S
I
V
N
R
C
L
I
R
R
T
-----
S
D
I
L
S
K
---
Y
L
P
V
------------
K
IEQVV-------
C
C
--
N
L
-----
T
P
-
L
Q
K
E
L
---------------------
Y
K
L
F
L
K
Q
A
K
-
P
-
V
----------
E
S
L
Q
-----
T
G
KI
S
V
S
S
L
--
S
S
I
---
T
S
-
L
----------
K
K
L
C
N
H
--
P
---
A
---
L
----
I
Y
E
K
--
C
--------------
L
T
G
EEG
F
-
D
------
G
--------------
A
L
D
L
F
P
--------------
Q
N
Y
-----
S
----------------
T
K
A
---
V
E
P
Q
L
S
--
G
K
M
L
V
L
D
Y
I
L
A
-
M
T
RTT
T
S
--
D
---
K
V
--
V
L
V
S
N
Y
T
Q
T
L
D
L
F
E
K
L
C
R
N
---------------------------------------
R
R
Y
L
Y
V
R
L
D
G
--------
T
M
S
I
K
K
R
A
K
I
V
E
R
F
N
N
P
S
S
P
E
F
I
-
F
M
L
S
-
S
K
A
G
G
C
G
L
N
L
I
G
A
N
R
L
V
M
F
D
P
D
W
N
P
A
N
--------
D
E
Q
A
M
A
R
V
W
R
D
G
Q
K
K
T
C
Y
I
Y
R
L
L
S
T
G
T
I
E
E
K
I
L
Q
R
Q
A
H
K
K
A
L
S
S
C
V
V
D
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
38.27
19%
-13
- C1 -
-
1Z6A
-
?
A:
[34-480]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
N
L
R
P
Y
Q
I
K
G
F
S
W
M
R
F
M
N
K
-----
L
G
F
G
I
C
L
A
D
D
M
G
L
G
K
T
L
Q
T
----
I
A
V
F
S
D
A
K
K
E
N
-----
E
L
-----
T
P
S
L
V
I
C
P
L
-
S
V
L
K
N
W
E
E
E
L
S
K
F
A
P
H-
L
R
F
--
A
V
F
H
E
------
D
R
S
-------------
K
I
K
L
E
D
Y
D
---
I
I
L
T
T
Y
A
V
L
L
R
D
T
-------
R
L
K
E
V
E
-
W
K
Y
I
V
I
D
E
A
Q
N
I
K
N
P
Q
----
T
K
I
F
K
A
V
-
K
-
E
L
-----
K
S
K
Y
--
R
I
A
L
T
G
T
P
--
I
E
N
K
V
D
D
L
W
S
I
M
T
-------
F
L
-------
N
P
G
L
L
G
----
S
-
Y
-
S
E
F
K
S
K
F
A
T
P
I
---------------------
K
K
GD
N
M
A
K
E
E
L
----
K
A
I
I
S
P
F
I
L
R
R
T
K
Y
---
D
K
A
I
I
N
---
D
L
P
D
------------
K
I
E
T
N
V
-------
Y
C
--
N
L
-----
T
P
-
E
Q
A
A
M
---------------------
Y
K
A
E
V
E
N
L
F
-
N
-
N
----------
I
D
S
V
TG---
I
K
--
R
K
G
M
I
L
S
T
-
L
---
L
K
-
L
----------
K
Q
I
V
D
H
--
P
---
A
---
L
----
L
K
----------------------------------------------------------------------------------------------
G
G
E
---
Q
S
V
R
R
S
--
G
K
M
I
R
T
M
E
I
I
E
-
E
A
L
D
-
E
G
--
D
---
K
I
--
A
I
F
T
Q
F
V
D
M
G
K
I
I
R
N
I
I
E
K
E
--------------------------------------
L
N
T
E
V
P
F
L
Y
G
--------
E
L
S
K
K
E
R
D
D
I
I
S
K
F
Q
N
N
P
--
S
V
K
F
I
V
L
S
-
V
K
A
G
G
F
G
I
N
L
T
S
A
N
R
V
I
H
F
D
R
W
W
-------------
D
Q
A
T
D
R
V
Y
R
I
G
Q
T
R
N
V
I
V
H
K
L
I
S
V
G
T
L
E
E
K
I
D
Q
L
L
A
F
K
R
S
L
F
K
D
I
I
S
S
G
D
S
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
37.19
17%
2
- C1 -
-
5JB2
3
?
A:
[7-481]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
H
G
Y
Q
L
E
A
V
A
P
A
L
R
---------
G
R
N
S
I
V
W
L
P
T
G
A
G
K
T
R
A
A
----
V
H
V
C
R
R
H
L
E
G
R
-----
R
G
-----
G
R
V
A
V
L
V
N
K
V
H
L
V
Q
Q
H
L
E
K
E
F
H
V
L
R
DA
F
K
V
--
T
A
V
S
G
------
D
S
S
H
K
C
--------
F
F
G
Q
L
A
K
G
S
D
----
V
I
C
T
A
Q
I
L
Q
N
A
L
L
S
G
EEE
A
R
V
E
L
T
D
-
F
S
L
L
V
I
D
E
C
H
H
T
Q
K
E
A
V
Y
N
-
K
I
M
L
S
Y
L
-
Q
K
K
L
S
G
Q
R
-
D
L
P
Q
--
I
L
G
L
T
A
S
P
--
G
T
G
G
E
T
S
F
E
G
A
V
E
H
I
L
Q
I
C
A
N
L
-------
D
T
E
V
I
A
----
S
-
A
-
Q
E
H
A
Q
H
L
Q
S
H
V
---------------------
P
---------
Q
----
P
T
K
Q
Y
D
L
C
Q
E
R
E
Q
D
P
F
-
G
Q
R
L
K
K
---
I
M
A
Q
------------
I
Q
E
H
---------
M
E
MP
E
L
-----
P
Q
N
F
G
T
Q
V
---------------------
Y
E
Q
R
I
V
E
L
E
N
R
A
A
----------
E
R
F
C
-----
R
K
--
T
R
V
C
A
--
L
-
H
L
R
R
Y
N
-
D
A
---------
L
L
I
N
D
T
VR
M
M
D
A
F
Q
--
C
----
L
Q
Q
F
--
Y
--------------
A
D
K
------KD
P
T
E
R
F
--------------
L
A
T
T
F
E
--------------
E
N
R
A
T
L
Q
-
A
----------------
L
A
G
---
D
Q
R
Y
E
N
--
P
R
L
S
K
L
E
E
I
L
Q
E
H
F
QPP
G
S
--
S
---
R
G
--
I
V
F
T
K
T
R
Q
S
A
H
S
L
L
S
W
L
Q
D
T
AGLCG---------------------------------
Q
H
I
R
A
A
V
L
T
G
SGHSNQ
A
K
G
M
T
Q
N
E
Q
Q
D
V
I
T
L
F
R
Y
G
---
E
L
N
-
L
L
F
S
-
T
S
V
A
E
E
G
L
D
I
P
E
C
N
I
V
V
R
Y
G
L
M
T
N
E
I
A
--------
M
V
Q
A
Q
G
R
A
R
A
Q
N
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
37.00
15%
-50
- C1 -
-
2XGJ
2
MTR4_YEAST
A:
[84-515]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
T
L
D
P
F
Q
D
T
A
I
S
C
I
D
---------
R
G
E
S
V
L
V
S
A
H
T
S
A
G
K
T
V
V
A
----
E
Y
A
I
A
Q
S
L
K
N
K
------------
Q
R
V
I
Y
T
S
P
I
K
A
L
S
N
Q
K
Y
R
E
L
L
A
E
F
G
--
D
-
V
--
G
L
M
T
G
------
D
I
T
---------------
I
N
P
D
A
G
---
C
L
V
M
T
T
E
I
L
R
S
M
L
Y
-
R
---
G
S
E
V
M
R
E
-
V
A
W
V
I
F
D
E
V
H
Y
M
R
D
K
E
R
G
--
V
V
W
E
E
T
I
-
I
-
L
L
---
P
-
D
K
V
R
--
Y
V
F
L
S
A
T
I
--
P
--
N
A
M
E
F
A
E
W
I
C
-------
K
I
-------
H
S
Q
P
C
H
----
I
V
Y
-
T
N
F
R
P
-----
T
---------------------
P
---------
L
----
Q
H
Y
L
F
P
A
H
G
---------
D
G
I
Y
L
---
V
V
D
E
------------
K
-----------------------
S
T
-
F
R
E
E
N
---------------------
F
Q
K
A
M
A
S
------------------
I
------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
Y
K
I
V
K
M
I
W
-
K
K
---
K
Y
--
N
---
P
V
--
I
V
F
S
F
S
K
R
D
C
E
E
L
A
L
K
M
S
K
L
DFNS
D
D
E
K
E
A
L
T
K
I
F
N
N
A
I
A
L
LPETDREL
P
Q
I
K
H
I
L
P
L
L
R
R
G
I
G
I
H
H
S
--------
G
L
L
P
I
L
K
E
V
I
E
I
L
F
Q
E
G
---
F
L
K
-
V
L
F
A
-
T
E
T
F
S
I
G
L
N
M
P
A
K
T
V
V
F
T
S
V
R
K
W
D
G
Q
Q
FRWVS
G
G
E
Y
I
Q
M
S
G
R
A
G
R
R
G
L
D
D
R
G
I
V
I
M
M
I
D
E
K
M
E
P
Q
V
A
K
G
M
V
K
G
Q
A
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
36.12
17%
-13
- C1 -
-
1WP9
-
?
A:
[1-486]
----------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
L
R
R
D
L
I
Q
P
R
I
Y
Q
E
V
I
Y
A
K
C
-------
K
E
T
N
C
L
I
V
L
P
T
G
L
G
K
T
L
I
A
----
M
M
I
A
E
Y
R
L
T
K
------
Y
G
-----
G
K
V
L
M
L
A
P
T
-
K
P
L
V
L
Q
H
A
E
S
F
R
R
L
---
F
N
L
--
P
P
E
K
I
------
V
A
L
T
G
E
K
S
P
----
E
E
R
S
K
A
W
A
R
A
K
---
V
I
V
A
T
P
Q
T
I
--
E
N
D
L
L
---
A
G
R
I
S
L
E
D
V
S
L
I
V
F
D
E
A
H
R
A
-----
V
G
N
Y
A
Y
V
F
I
A
-
R
-
E
Y
--
K
R
-
Q
A
K
N
P
L
V
I
G
L
T
A
S
P
GS
T
P
E
K
I
M
E
V
I
N
N
L
G
-------
I
E
-------
H
I
E
Y
R
S
ENSP
D
-
V
-
R
P
Y
V
K
G
I
R
F
E
W
---------------------
V
---------
R
V
D
L
P
E
I
Y
K
E
V
R
K
L
L
R
E
M
L
R
D
A
L
K
P
L
A
E
T
GL
L
E
S
S
------------
S
------------
P
D
--
I
P
-----
K
K
-
E
V
L
R
A
---------------------
G
Q
I
I
N
E
E
M
A
-
K
-
G
NHDLRGL
L
L
Y
H
A
M
A
-----
L
K
--
L
H
H
A
I
--
E
-
L
---
L
E
-
T
QG
L
S
A
L
R
A
Y
I
K
K
L
Y
E
E
--
A
---
K
---
A
----
G
S
T
K
--
A
--------------
S
K
E
---
I
-
F
------
S
--------------
D
K
R
M
K
K
--------------
A
I
S
-----
L
----------------
L
V
Q
---
A
K
E
I
G
L
DH
P
K
M
D
K
L
K
E
I
I
R
E
Q
L
---
Q
R
--
K
QN
S
K
I
--
I
V
F
T
N
Y
R
E
T
A
K
K
I
V
N
E
L
V
K
D
--------------------------------------
G
I
K
A
K
R
F
V
G
Q
--------
A
S
K
Q
R
E
Q
K
L
I
L
D
E
F
A
R
G
E
F
---
N
-
V
L
V
A
-
T
S
V
G
E
E
G
L
D
V
P
E
V
D
L
V
V
F
Y
E
P
V
P
S
A
I
R
--------
S
I
Q
R
R
G
R
T
G
R
H
M
P
G
R
V
I
I
L
M
A
K
G
T
R
D
E
A
Y
Y
W
S
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
36.01
26%
-137
- C1 -
-
5IVL
-
?
B:
[244-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
F
G
R
T
K
R
R
V
D
E
L
A
E
A
L
N
L
R
---------------------------------------
G
Y
A
A
E
G
I
H
G
--------
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
---
E
-
I
L
V
A
-
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
Q
D
P
E
S
--------
Y
V
H
R
I
G
R
T
G
R
A
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
35.96
15%
-47
- C1 -
-
4U4C
3
MTR4_YEAST
A:
[72-512]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
T
L
D
P
F
Q
D
T
A
I
S
C
I
D
---------
R
G
E
S
V
L
V
S
A
H
T
S
A
G
K
T
V
V
A
----
E
Y
A
I
A
Q
S
L
K
N
K
------------
Q
R
V
I
Y
T
S
P
I
K
A
L
S
N
Q
K
Y
R
E
L
L
A
E
F
G
--
D
-
V
--
G
L
M
T
G
------
D
I
T
---------------
I
N
P
D
A
G
---
C
L
V
M
T
T
E
I
L
R
S
M
L
Y
-
R
---
G
S
E
V
M
R
E
-
V
A
W
V
I
F
D
E
V
H
Y
M
R
D
K
E
R
G
--
V
V
W
E
E
T
I
-
I
-
L
L
---
P
-
D
K
V
R
--
Y
V
F
L
S
A
T
I
--
P
--
N
A
M
E
F
A
E
W
I
C
-------
K
I
-------
H
S
Q
P
C
H
----
I
-
V
Y
T
N
F
R
-----
P
T
---------------------
P
---------
L
----
Q
H
Y
L
F
P
A
H
---------
G
D
G
I
Y
L
---
V
V
D
E
------------
K
-----------------------
S
T
-
F
R
E
E
N
---------------------
F
Q
K
A
M
A
S
------------------
I
------
S
N
-----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
G
D
I
Y
K
I
V
K
M
I
W
-
K
K
---
K
Y
--
N
---
P
V
--
I
V
F
S
F
S
K
R
D
C
E
E
L
A
L
K
M
S
K
L
DFNS
D
D
E
K
E
A
L
T
K
I
F
N
N
A
I
ALLP
E
T
D
R
E
L
P
Q
I
K
H
I
L
P
L
L
R
R
G
I
G
I
H
H
S
--------
G
L
L
P
I
L
K
E
V
I
E
I
L
F
Q
E
G
---
F
L
K
-
V
L
F
A
-
T
E
T
F
S
I
G
L
N
M
P
A
K
T
V
V
F
T
S
V
R
K
W
D
G
Q
Q
FRWVS
G
G
E
Y
I
Q
M
S
G
R
A
G
R
R
G
L
D
D
R
G
I
V
I
M
M
I
D
E
K
M
E
P
Q
V
A
K
G
M
V
K
G
Q
A
D
R
L
D
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
35.51
17%
6
- C1 -
-
5JAJ
7
?
A:
[9-481]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
H
G
Y
Q
L
E
A
V
A
P
A
L
R
---------
G
R
N
S
I
V
W
L
P
T
G
A
G
K
T
R
A
A
----
V
H
V
C
R
R
H
L
E
G
R
-----
R
G
-----
G
R
V
A
V
L
V
N
K
V
H
L
V
Q
Q
H
L
E
K
E
F
H
V
L
R
DA
F
K
V
--
T
A
V
S
G
------
D
S
S
H
K
C
--------
F
F
G
Q
L
A
K
G
S
D
---
V
V
I
C
T
A
Q
I
L
Q
N
A
L
L
S
G
EEE
A
R
V
E
L
T
D
-
F
S
L
L
V
I
D
E
C
H
H
T
Q
K
E
A
V
Y
N
-
K
I
M
L
S
Y
L
Q
K
-
K
L
S
G
Q
R
-
D
L
P
Q
--
I
L
G
L
T
A
S
P
--
G
T
G
G
E
T
S
F
E
G
A
V
E
-------
H
I
L
Q
I
C
A
N
L
D
T
E
V
I
A
----
S
-
A
-
Q
-----------------------------------------
Q
----
P
T
K
Q
Y
D
L
C
Q
E
R
E
Q
D
P
F
-
G
Q
R
L
K
K
---
I
M
A
Q
------------
I
------------
Q
E
--
H
M
EMPEL
P
Q
N
F
G
T
Q
V
---------------------
Y
E
Q
R
---------------------
I
------
V
E
--
L
E
N
R
A
A
-
E
-
R
---
F
C
R
K
----------
T
R
V
C
A
L
--
H
---
L
R
R
Y
N
D
A
L
L
I
N
D
T
VR
M
--------------
M
D
A
---
F
-
Q
------
C
--------------
L
Q
Q
F
Y
A
DKD
P
T
E
R
F
L
A
T
T
F
E
E
N
R
A
T
L
Q
-
A
----------------
L
A
G
---
D
Q
R
Y
E
N
--
P
R
L
S
K
L
E
E
I
L
Q
E
H
F
Q--
G
S
--
S
---
R
G
--
I
V
F
T
K
T
R
Q
S
A
H
S
L
L
S
W
L
Q
D
T
AGLCG---------------------------------
Q
H
I
R
A
A
V
L
T
G
SGHSNQ
A
K
G
M
T
Q
N
E
Q
Q
D
V
I
T
L
F
R
Y
G
---
E
L
N
-
L
L
F
S
-
T
S
V
A
E
E
G
L
D
I
P
E
C
N
I
V
V
R
Y
G
L
M
T
N
E
I
A
--------
M
V
Q
A
Q
G
R
A
R
A
Q
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
34.80
20%
36
- C1 -
-
5JXR
-
?
A:
[7-639]
------------------------
S
K
E
D
D
T
L
R
R
F
R
Y
L
L
G
L
T
D
L
F
R
H
F
I
E
T
N
P
N
P
K
I
R
E
I
M
K
E
I
D
R
Q
N
E
E
E
A
R
Q
---
R
K
R
G
G
R
Q
G
G
A
T
S
E
R
R
R
R
T
E
A
E
E
D
A
E
L
L
K
D
E
K
D
G
G
S
A
E
T
V
F
R
E
S
P
P
F
I
Q
G
T
M
R
-----
D
Y
Q
I
A
G
L
N
W
L
I
S
L
H
E
N
G
I
S
G
I
L
----------------------------------
A
D
E
M
G
L
G
K
T
L
Q
T
I
A
F
L
G
Y
L
R
H
I
M
G
I
T
G
-----
P
--------
H
L
V
T
V
P
K
-
S
T
L
D
N
W
K
R
E
F
E
K
W
T
P
-------
E
V
N
V
L
------
V
L
Q
G
A
K
E
E
R
----
H
Q
L
I
N
D
R
L
V
D
E
NFD
V
C
I
T
S
Y
E
M
I
L
R
---
E
K
---
A
H
L
K
K
F
A
-
W
E
Y
I
I
I
D
E
A
---------------
S
L
A
-
Q
-
V
I
--
R
M
F
N
S
R
N
--
R
L
L
I
T
G
T
P
--
L
Q
N
N
L
H
E
L
W
A
L
L
N
-------
F
L
-------
L
P
D
V
F
G
----
D
-
S
-
E
A
F
D
Q
W
F
S
G
Q
D
---------------------
R
----------------------
D
Q
D
T
V
V
Q
Q
L
H
R
V
L
R
P
---
F
L
L
R
------------
R
------------
V
K
--
S
D
-----
V
E
-
K
S
L
L
P
---------------------
K
K
E
I
N
V
Y
I
G
-
M
-
S
----------
E
M
Q
V
-----
K
W
--
Y
Q
K
I
L
--
E
-------------------
K
D
I
D
A
V
--
N
---
G
---
A
----
G
G
K
R
--
E
--------------
S
K
T
---
R
-
L
------
L
--------------
N
I
V
M
Q
L
--------------
R
K
C
-----
C
N
HPYLFEGAEPGPPYT
T
D
E
---
H
L
I
Y
N
A
--
G
K
M
V
V
L
D
K
L
L
K
R
I
Q
---
K
Q
--
G
S
--
R
V
--
L
I
F
S
Q
M
S
R
L
L
D
I
L
E
D
Y
C
V
F
R
---------------------------------------
G
Y
K
Y
C
R
I
D
G
--------
S
T
A
H
E
D
R
I
A
A
I
D
E
Y
N
K
P
G
S
-
D
K
F
-
I
F
L
L
T
T
R
A
G
G
L
G
I
N
L
T
T
A
D
I
V
I
L
Y
D
S
D
W
N
P
Q
A
--------
D
L
Q
A
M
D
R
A
H
R
I
G
Q
T
K
Q
V
V
V
Y
R
F
V
T
D
N
A
I
E
E
K
V
L
E
R
A
A
Q
K
L
R
L
D
Q
L
V
I
Q
Q
G
R
A
Q
V
A
A
K
A
A
A
N
K
D
E
L
L
S
-
M
-
I
Q
H
G
A
E
K
V
F
Q
T
K
G
AFGTMAEKGSQ
L
D
D
D
D
I
D
A
I
L
Q
A
G
E
T
R
T
K
E
L
N
A
R
Y
E
K
L
G
I
D
D
L
Q
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
34.52
26%
-42
- C1 -
-
1HV8
-
H669_METJA
A:
[227-337]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
A
L
C
R
L
L
---
K
N
--
K
---
E
F
Y
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
-
D
--------------------------------------
I
G
F
K
A
G
A
I
H
G
--------
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
---
I
R
-
I
L
I
A
-
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
N
P
E
S
--------
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------