@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUF4: (2017-12-18 )
MINYLHQEQNWQSQLSDLITDPLELLNLLELSTDQLLSGAILASEKFKLRVPRAFVGKMNAKDPLDPLLLQVLPHHLELEEHPEFVTDPLGEEAANQLPGVLHKYKSRFLLTLTGACAVHCRYCFRRHFPYQENLPKNEDWLNIKNYIESNPDINEVILSGGDPLTLSNRKLALWLERLSSLKQVKILRIHSRVPIVIPNRIDEELISLLKNSRLRIILVVHSNHASELDDFTCSKLLQLSEHHITVLNQAVLLKGVNDSAQTLTDLSYRLFEARIMPYYLHVLDKVKGAQHFDLIPSEIDAIYQDVLASLPGYLVPKLVREIAGEKNKTPLFGATTF
Atome Classification :
(20 SA)
---------------.....-....10..---------------......20........30........40........50........60........70.......-.80..--------......90----------...-....-.100.......110..-..--...120.......130------.------.-.-...--------------.140--.....-....150-------.----------------.--..--.....160-------.-.-.....---.-----170---.....--...180--....--------------.--....190.......200.-......210...-....----220......-.-------------230------------.-------........240.----.---..--------...250.....-.-.260-.......270---...-....280.-.....-.290----..---------.-.....300.......310.--......320.......330......-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------MINYL-HQEQ
N
W
Q
S
---------------
Q
L
S
D
L
IT
D
P
L
E
L
L
N
L
L
EL
S
T
D
Q
L
L
S
G
AILASE
K
F
K
L
RV
P
R
A
F
VGKMNAKDP
L
D
P
L
L
L
Q
V
L
P
H
HL
E
-
L
E
EHP--------
E
F
VTDPL
G
----------
E
E
A
-
A
N
Q
L
-
P
G
V
L
H
K
YKS
R
F
L
L
T
LT-
G
A
--
C
A
V
H
C
R
Y
C
F
R
RHF
P
Y
Q------E------N-L-PKN--------------E
D
----
W
L
N
I
K
-
N
Y
IES---------N----------------P--
D
I
--
N
E
V
I
LS-G-------G-D-
P
L
TLS---N-----
R
K
----
L
A
L
W
L
--
E
R
L
S
----
S
L
K
Q
--------------
V
--
K
I
L
R
IHSRV
P
I
V
IPNRI
D
-
E
E
L
I
S
L
L
KNS
R
L
-
R
I
I
L
----
V
V
HSNH
A
S
E
-
L
-------------
D
--------------
D
-------
F
T
C
S
K
L
L
Q
LS
E
H
----
H
---
I
T
--------
V
L
N
Q
A
V
L
LKGV-N-D
S
A
Q
-
T
L
T
D
L
S
Y
R
L
F
---
E
A
R
-
I
M
P
Y
Y
L
H
V
-
L
D
K
VK-GAQ-----HF---------D-L
I
P
S
E
I
D
A
I
Y
Q
D
V
L
A
SL
P
G
--
Y
L
V
P
K
L
V
R
E
I
AGEKNKTPLFGATTF-
31
HHSearch
87.53
31%
-26
- C3 -
-
2A5H
3
KAMA_CLOSU
D:
[14-343]
-------------------
D
-
A
D
W
N
D
W
R
W
---------------
Q
V
R
N
R
I
E
T
V
E
E
L
K
K
Y
I
P
L
T
K
E
E
E
E
-
G
V
A
Q
C
V
K
S
L
R
M
A
I
T
P
Y
Y
L
S
L
I
D
P
N
D
P
N
D
P
V
R
K
Q
A
I
P
T
A
L
E
-
L
N
K
A
A
--------
A
D
L
E
D
P
L
H
----------
E
D
T
-
D
S
P
V
-
P
G
L
T
H
R
Y
P
D
R
V
L
L
L
I
T
-
D
M
--
C
S
M
Y
C
R
H
C
T
R
R
R
F
A
G
Q
------
S
------
D
-
D
-
S
M
P
M-------------
E
R
----
I
D
K
A
I
-
D
Y
I
R
N
---------
T
----------------
P
--
Q
V
--
R
D
V
L
L
S
-
G
-------
G
-
D
-
A
L
L
V
S
---
D
-----
E
T
----
L
E
Y
I
I
--
A
K
L
R
----
E
I
P
H
--------------
V
--
E
I
V
R
I
G
S
R
T
P
V
V
L
P
Q
R
I
T
-
P
E
L
V
N
M
L
K
K
Y
H
--
P
V
W
L
----
N
T
H
F
N
H
P
N
E
-
I
-------------
T
--------------
E
-------
E
S
T
R
A
C
Q
L
L
A
D
A
----
G
---
V
P
--------
L
G
N
Q
S
V
L
L
R
G
V
-
N
-
D
C
V
H
-
V
M
K
E
L
V
N
K
L
V
---
K
I
R
-
V
R
P
Y
Y
I
Y
Q
-
C
D
L
S
L
-
G
L
E
-----
H
F
---------
R
-
T
P
V
S
K
G
I
E
I
I
E
G
L
R
G
H
T
S
G
--
Y
C
V
P
T
F
V
V
D
A
P
G
G
G
G
K
T
P
V
M
P
N
----
30
HHSearch
87.39
31%
-28
* C3 *
-
2A5H
3
KAMA_CLOSU
A:
[14-343]
-------------------
D
-
A
D
W
N
D
W
R
W
---------------
Q
V
R
N
R
I
E
T
V
E
E
L
K
K
Y
I
P
L
T
K
E
E
E
E
-
G
V
A
Q
C
V
K
S
L
R
M
A
I
T
P
Y
Y
L
S
L
I
D
P
N
D
P
N
D
P
V
R
K
Q
A
I
P
T
A
L
E
-
L
N
K
A
A
--------
A
D
L
E
D
P
L
H
----------
E
D
T
-
D
S
P
V
-
P
G
L
T
H
R
Y
P
D
R
V
L
L
L
I
T
-
D
M
--
C
S
M
Y
C
R
H
C
T
R
R
R
F
A
G
Q
------
S
------
D
-
D
-
S
M
P
M
-------------
E
R
----
I
D
K
A
I
-
D
Y
I
R
N
---------
T
----------------
P
--
Q
V
--
R
D
V
L
L
S
-
G
-------
G
-
D
-
A
L
L
V
S
---
D
-----
E
T
----
L
E
Y
I
I
--
A
K
L
R
----
E
I
P
H
--------------
V
--
E
I
V
R
I
G
S
R
T
P
V
V
L
P
Q
R
I
T
-
P
E
L
V
N
M
L
K
K
Y
H
--
P
V
W
L
----
N
T
H
F
N
H
P
N
E
-
I
-------------
T
--------------
E
-------
E
S
T
R
A
C
Q
L
L
A
D
A
----
G
---
V
P
--------
L
G
N
Q
S
V
L
L
R
G
V
-
N
-
D
C
V
H
-
V
M
K
E
L
V
N
K
L
V
---
K
I
R
-
V
R
P
Y
Y
I
Y
Q
-
C
D
L
S
L
-
G
L
E
-----
H
F
---------
R
-
T
P
V
S
K
G
I
E
I
I
E
G
L
R
G
H
T
S
G
--
Y
C
V
P
T
F
V
V
D
A
P
G
G
G
G
K
T
P
V
M
P
N
----
1
PsiBlast_PDB
85.80
30%
-30
- C3 -
-
2A5H
3
KAMA_CLOSU
A:
[19-340]
-------------------------
D
W
R
W
---------------
Q
V
R
N
R
I
E
T
V
E
E
L
K
K
Y
I
P
L
T
K
E
E
E
-
E
G
V
A
Q
C
V
K
S
L
R
M
A
I
T
P
Y
Y
L
S
L
I
D
P
N
D
P
N
D
P
V
R
K
Q
A
I
P
T
A
L
E
-
L
N
K
A
A
--------
A
D
L
E
D
P
L
H
----------
E
D
T
-
D
S
P
V
-
P
G
L
T
H
R
Y
P
D
R
V
L
L
L
I
T
-
D
M
--
C
S
M
Y
C
R
H
C
T
R
R
R
F
A
G
Q
------
S
------
D
-
D
-
S
M
P
--------------
M
E
----
R
I
D
K
A
I
D
Y
I
R
N
---------
T
----------------
P
--
Q
V
--
R
D
V
L
L
S
-
G
-------
G
-
D
-
A
L
L
V
S
---
D
-----
E
T
----
L
E
Y
I
I
--
A
K
L
R
----
E
I
P
H
--------------
V
--
E
I
V
R
I
G
S
R
T
P
V
V
L
P
Q
R
I
T
-
P
E
L
V
N
M
L
K
K
Y
H
--
P
V
W
L
----
N
T
H
F
N
H
P
N
E
-
I
-------------
T
--------------
E
-------
E
S
T
R
A
C
Q
L
L
A
D
A
----
G
---
V
P
--------
L
G
N
Q
S
V
L
L
R
G
V
-
N
-
D
C
V
H
-
V
M
K
E
L
V
N
K
L
V
---
K
I
R
-
V
R
P
Y
Y
I
Y
Q
-
C
D
L
S
L
-
G
L
E
-----
H
F
---------
R
-
T
P
V
S
K
G
I
E
I
I
E
G
L
R
G
H
T
S
G
--
Y
C
V
P
T
F
V
V
D
A
P
G
G
G
G
K
T
P
V
-------
33
HHSearch
51.70
15%
-36
- C3 -
-
3RFA
1
RLMN_ECOLI
A:
[115-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
L
C
V
S
S
Q
-
V
G
--
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
F
N
------
R
----------
N
L
R
V
-------------
S
E
----
I
I
G
Q
V
-
W
R
A
A
K
I
V
GAAKVTG
Q
----------------
R
--
P
I
--
T
N
V
V
M
M
-
G
M------
G
-
E
-
P
L
L
N
----
L
-----
N
N
----
V
V
P
A
M
--
E
I
M
L
----
D
D
F
G
FGLS----------
K
--
R
R
V
T
L
-----
S
T
S
G
V
V
P
A
-
L
--
D
K
L
G
D
M
I
---
D
V
A
L
----
A
I
S
L
H
A
P
N
D
-
E
I
R
D
E
I
VPINKKYN
I
--------------
E
-------
T
F
L
A
A
V
R
R
Y
L
E
K
SNAN
Q
---
G
R
--------
V
T
I
E
Y
V
M
L
D
H
V
-
N
-
D
G
T
E
-
H
A
H
Q
L
A
E
L
L
K
---
D
T
P
-
C
-
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
-----
Y
G
---------
R
-
S
S
N
S
R
I
D
R
F
S
K
V
L
M
---------------------------------
26
Fugue
51.08
17%
-16
- C3 -
-
3RFA
1
RLMN_ECOLI
A:
[17-349]
---------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
---------------
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
-----
I
N
K
V
L
R
G
K
L
K
E
V
-------
A
E
I
R
A
P
E
V
V
-
E
E
Q
R
S
--------
S
D
G
T
I
K
W
A
----------
I
A
V
G
D
Q
R
V
-
E
T
V
Y
I
P
E
D
D
R
A
T
L
C
V
S
-
S
Q
VG
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
F
N
------
R
------
N
-
L
-
R
V
S
--------------
E
I
----
I
G
Q
V
W
-
R
A
A
K
I
V
GAAKVTG-
Q
----------------
R
--
P
I
--
T
N
V
V
M
M
-
G
M------
G
-
E
-
P
L
L
------------
N
----
L
N
N
V
V
--
P
A
M
E
----
I
M
L
D
--------------
D
--
F
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
-
P
A
L
D
K
L
G
D
M
I
D
V
-
A
L
A
I
----
S
L
H
A
P
N
D
E
I
-
R
-------------
D
--------------
E
I
VPINKK
Y
N
I
E
T
F
L
A
A
V
R
R
----
Y
---
L
E
K
SNANQG
R
V
T
I
E
Y
V
M
L
D
H
V
-
N
-
D
G
T
E
-
H
A
H
Q
L
A
E
L
L
----
K
D
T
-
P
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
-----
Y
G
---------
R
-
S
S
N
S
R
I
D
R
F
S
K
V
L
M
S
------
Y
G
F
T
T
I
V
R
K
T
R
G
D
-------------
41
HHSearch
47.11
16%
-41
- C3 -
-
2YX0
-
TYW1_PYRHO
A:
[71-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
C
L
Q
M
T
P
V
L
A
W
--
C
T
H
N
C
I
F
C
W
R
P
M
E
N
F
L
------
G
------
T
-
E
L
P
Q
P
W-------------
D
D
P
A
F
I
V
E
E
S
I
-
K
A
Q
R
K
---------
L
L
I
GYKPKVDK
K
K
F
E
E
A
W
--
N
P
--
T
H
A
A
I
S
L
S
-------
G
-
E
-
P
M
L
Y
----
P
-----
Y
-----
M
G
D
L
V
--
E
E
F
H
----
K
R
G
------------------
F
T
T
F
-----
I
V
T
N
G
T
I
P
--
E
R
L
E
E
M
I
K
E
D
K
L
-
P
T
Q
L
----
Y
V
S
I
T
A
P
D
I
E
T
Y
N
S
V
NIPMIPD
G
-
W
--------------
E
-------
R
I
L
R
F
L
E
L
M
R
D
L
----
P
---
T
R
--------
T
V
V
R
L
T
L
V
K
G
E
-
N
-
M
H
---
S
P
E
K
Y
A
K
L
I
L
---
K
A
R
-
P
M
F
V
E
A
K
A
-
Y
M
-------NRLTI
N
N
---------
M
-
P
S
H
Q
D
I
R
E
F
A
E
A
L
V
K
H
L
P
G
--
Y
H
I
-----------------------
36
HHSearch
44.66
16%
-33
- C3 -
-
2FB2
1
MOAA_STAA8
A:
[12-201]
------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
R
D
L
A
L
S
V
T
-
D
R
--
C
N
F
R
C
D
Y
C
M
P
K
E
V
F
G
D
------
D
FVFLPK
N
-
E
-
L
L
T
F
-------------
D
E
----
M
A
R
I
A
-
K
V
Y
A
E
--------------------------
L
--
G
V
--
K
K
I
R
I
T
-
G
-------
G
-
E
-
P
L
M
R
----
R
-----
D
-----
L
D
V
L
I
--
A
K
L
N
----
Q
I
D
G
--------------
I
--
E
--
D
I
---
G
L
T
T
N
G
L
L
L
K
-
K
-
H
G
Q
K
L
Y
D
A
G
L
--
R
R
I
----
N
V
S
L
D
A
I
D
D
T
L
F
Q
S
I
NNRNIK---
A
--------------
T
-------
T
I
L
E
Q
I
D
Y
A
T
S
I
----
G
---
L
N
--------
V
K
V
N
V
V
I
Q
K
G
I
-
N
-
D
--
D
-
Q
I
I
P
M
L
E
Y
F
K
---
D
K
H
-
I
E
-
I
R
F
I
E
-
F
M
D
V
G
-
N
-------------------------------------------------------------------
52
HHSearch
43.70
16%
-25
- C3 -
-
5L7L
1
?
A:
[16-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
T
K
P
-
L
P
--
C
P
G
K
C
I
Y
C
P
T
F
A
A
T
P
Q
------
S
------
Y
-
T
-
P
E
S
P
A
V
L
R
A
K
S
C
EYQ
A
Y
K
Q
----
V
A
L
R
L
-
R
I
I
Q
D
---------
M
----------------
G
H-
P
T
D
K
V
E
L
I
I
M
-
G
-------
G
-
T
-
F
L
S
A
D
---
I
-----
T
Y
Q
Y
G
F
I
K
D
C
Y
--
D
A
L
N
----
G
V
V
A
GS
L
E
E
A
K
T
I
N
ETAQ
H
--
R
C
V
G
L
---
C
I
E
T
R
P
D
I
C
G
-
K
A
E
I
Q
R
M
I
D
F
G
T
--
T
R
V
----
E
L
G
V
Q
M
L
D
D
-
D
IYKLVERGHR---
V
--------------
S
-------
D
V
A
E
A
T
C
L
L
R
E
Y
----
G
---
L
K
--------
V
H
Y
H
W
M
P
--
G
L
P
G
-
S
S
P
E
-
K
D
L
A
L
S
R
M
V
F
E
DP
R
F
C
-
P
D
G
L
K
L
Y
P
-
T
M
V
V
E
-
G
T
I
-----
L
E
Q
W
W
K
E
GR
Y
T
P
-
Y
P
N
G
T
M
T
G
L
I
A
D
I
K
A
L
V
P
P
--
Y
-------------------------
35
HHSearch
43.46
16%
-30
- C3 -
-
1TV8
1
MOAA_STAA8
B:
[12-201]
------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
R
D
L
R
L
S
V
T
-
D
R
--
C
N
F
R
C
D
Y
C
M
P
K
E
V
F
G
D
DFVFLP
K
------
N
-
E
-
L
L
T
F
-------------
D
E
----
M
A
R
I
A
-
K
V
Y
A
E
--------------------------
L
--
G
V
--
K
K
I
R
I
T
-
G
-------
G
-
E
-
P
L
M
R
----
R
-----
D
-----
L
D
V
L
I
--
A
K
L
N
----
Q
I
D
G
--------------
I
--
E
--
D
I
---
G
L
T
T
N
G
L
L
L
K
-
K
-
H
G
Q
K
L
Y
D
A
G
L
--
R
R
I
----
N
V
S
L
D
A
I
D
D
T
L
F
Q
S
I
N
NRNIK---
A
--------------
T
-------
T
I
L
E
Q
I
D
Y
A
T
S
I
----
G
---
L
N
--------
V
K
V
N
V
V
I
Q
K
G
I
-
N
-
D
--
D
-
Q
I
I
P
M
L
E
Y
F
K
---
D
K
H
-
I
E
-
I
R
F
I
E
-
F
M
D
V
G
-
N
-------------------------------------------------------------------
23
Fugue
42.82
16%
-104
- C3 -
-
5TGQ
1
?
A:
[1-226]
----------------
M
N
F
K
-
K
Y
E
E
N
L
V
A
---------------
S
I
E
E
V
I
Q
R
I
I
D
--------------------
D
K
H
R
P
N
I
----
I
G
K
T
R
V
G
A
E
V
S
D
Y
L
E
D
E
F
V
K
Y
I
S
----------------------------------------------
S
G
K
S
S
S
L
Y
D
A
Q
-
G
A
--
P
K
E
K
T
K
N
P
W
D
A
R
C
K
F
K
------
F
------
M
-
D
-
R
E
E
--------------
E
I
----
W
I
D
F
K
-
A
F
K
I
T
---------
N
----------------
M
--
D
S
--
N
P
D
I
G
T
---------------------
P
-----
N
K
----
I
V
K
F
I
--
H
E
-----------------------------------------------------
G
N
F
Y
L
-
V
F
V
L
----
V
Y
Y
E
S
K
Q
D
G
--------------------------------------------
V
E
F
V
K
Y
----
N
---
N
D
---------
Y
K
K
V
Y
L
L
K
D
V
-
N
-
E
S
---------
F
R
I
N
---
P
K
P
-
Q
M
Q
V
N
I
A
A
-
E
P
T
Y
R
-
T
R
E
-----
E
F
I
--------
H
-
F
F
V
K
K
W
K
E
S
F
E
R
Q
I
K
S
L
E
K
K
E
I
M
L
K
D
L
E
D
K
L
K
N
S
N
D
N
S
I
--------
25
Fugue
41.76
20%
-7
- C3 -
-
4KKI
19
TCO1_HUMAN
A:
[24-434]
E
I
C
E
V
S
EENYIRL
K
P
L
L
N
T
M
-
I
Q
S
N
Y
N
R
G
TSA
V
N
V
V
L
S
L
K
L
V
GI
Q
I
Q
T
L
M
Q
K
M
I
Q
Q
I
K
Y
N
V
K
S
R
L
S
D
V
S
S
G
E
L
A
L
I
I
L
A
L
G
V
C
R
N
A
E
E
N
L
I
Y
D
Y
H
L
I
D
K
L
E
N
K
F
Q
A
E
I
E
N
M
E
A
H
N
GTPLTN
Y
Y
Q
L
S
L
D
V
L
A
L
C
L
F
NGNYS
T
A
E
V
-
V
N
H
F
T
P
E
N
K
N
Y
Y
F
G
S
Q
F
S
V
D
T
-
G
A
--
M
A
V
L
A
L
T
C
V
K
K
S
L
I
N
G
------
Q
------
I
-
K
-
A
D
E
--------------
G
S
----
L
K
N
I
S
-
I
Y
T
K
S
------------------------------
L
--
V
E
K
I
L
S
-
E
KKENGLI
G
-
N
-
T
F
S
T
G
---
E
-----
A
M
----
Q
A
L
F
V
S
S
D
Y
Y
N
ENDW
N
C
Q
Q
--------------
T
L
N
T
V
L
T
E
I
S
Q
G
A
F
S
N
P
N
A
A
A
-
Q
V
L
P
A
L
M
G
K
T
F
L
-
D
I
N
K
DSSC
V
S
A
S
G
N
F
N
I
-
Q
-------------
S
--------------
Y
-------
I
S
V
N
Y
S
V
R
I
N
E
T
----
Y
F
T
N
V
T
--------
V
L
N
G
S
V
F
L
S
V
M
-
E
-
K
A
Q
K
M
N
D
T
I
F
G
F
T
M
E
---
E
R
S
-
W
G
P
Y
I
T
C
I
-
Q
G
-------------------------
L
C
A
N
N
N
D
R
T
Y
W
E
L
L
S
G
--
G
--
E
P
L
S
Q
G
A
G
S
Y
V
V
R
N
G
E
N
L
E
V
R
W
S
K
Y
L
51
HHSearch
40.95
13%
-24
- C3 -
-
5FEW
4
HYDE_THEMA
A:
[64-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
I
I
E
F
S
-
N
V
--
C
R
K
N
C
L
Y
C
G
L
R
R
D
N
K
N
------
L
------
K
-
R
Y
R
M
T
P
-------------
E
E
----
I
V
E
R
A
-
R
L
A
V
Q
--------------------------
F
--
G
A
--
K
T
I
V
L
Q
-
S
-------
G
-
E
D
P
Y
Y
M
----
P
-----
D
V
----
I
S
D
I
V
--
K
E
I
K
----
K
M
G
--------------------
V
A
V
T
L
---
S
L
G
--
E
W
P
-
R
E
Y
Y
E
K
W
K
E
A
G
A
--
D
R
Y
----
L
L
R
H
E
T
A
N
P
V
L
H
R
K
L
R
PDTS----
F
--------------
E
-------
N
R
L
N
C
L
L
T
L
K
E
L
----
G
---
Y
E
--------
T
G
A
G
--
S
M
V
G
L
P
G
-
Q
T
I
D
-
D
L
V
D
D
L
L
F
L
K
---
E
H
D
-
F
D
M
V
G
I
G
P
-
F
I
P
H
P
-
D
T
P
-----
L
A
NEK------
K
-
G
D
F
T
L
T
L
K
M
V
A
L
T
R
I
L
L
P
D
--
S
N
------------------------
48
HHSearch
38.97
19%
20
- C3 -
-
4JC0
1
RIMO_THEMA
A:
[138-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
A
Y
V
K
I
S
-
D
G
--
C
D
R
G
C
T
F
C
S
I
P
S
F
K
G
S
------
L
--------
R
-
S
R
S
I
-------------
E
D
----
I
T
R
E
V
-
E
D
L
L
K
--------------------------
E
--
G
K
--
K
E
I
I
L
V
-
A
-------
Q
-
D
-
T
T
S
Y
G
---
I
DLYRK
Q
A
----
L
P
D
L
L
--
R
R
L
N
----
S
L
N
G
--------------
E
--
F
W
I
R
----
V
M
Y
L
H
P
D
H
L
T
-
E
E
I
I
S
A
M
L
E
L
D
K
V
V
K
Y
F
----
D
V
P
V
Q
H
G
S
D
-
K
I
L
K
L
M
GRTKS---
S
--------------
E
-------
E
L
K
K
M
L
S
S
I
R
E
R
FP--
D
---
A
V
--------
L
R
T
--
S
I
I
V
G
F
-
P
G
E
T
E
E
-
D
F
E
E
L
K
Q
F
V
E
---
E
I
Q
-
F
D
K
L
G
A
F
V
-
Y
S
D
E
E
-
G
T
V
-----
A
F
---------
N
------------------------------------------------
47
HHSearch
38.23
13%
-23
- C3 -
-
5FF3
5
HYDE_THEMA
A:
[51-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
R
A
I
I
E
F
S
-
N
V
--
C
R
K
N
C
L
Y
C
G
L
R
R
D
N
K
N
------
L
------
K
-
R
Y
R
M
T
P
-------------
E
E
----
I
V
E
R
A
-
R
L
A
V
Q
--------------------------
F
--
G
A
--
K
T
I
V
L
Q
-
S
-------
G
E
D
-
P
Y
-
M
----
P
-----
D
V
----
I
S
D
I
V
--
K
E
I
K
----
K
M
G
------------------
V
A
V
T
L
S
-----
L
G
--
E
W
P
-
R
E
Y
Y
E
K
W
K
E
A
G
A
--
D
R
Y
----
L
L
R
H
E
T
A
N
P
-
V
L
H
R
K
L
R
PDTS---
F
--------------
E
-------
N
R
L
N
C
L
L
T
L
K
E
L
----
G
---
Y
E
--------
T
G
A
G
--
S
M
V
G
L
P
G
-
Q
T
I
D
-
D
L
V
D
D
L
L
F
L
K
---
E
H
D
-
F
D
M
V
G
I
G
P
-
F
I
P
H
P
-
D
T
P
-----
L
A
NEK------
K
-
G
D
F
T
L
T
L
K
M
V
A
L
T
R
I
L
L
P
D
--
S
-------------------------
45
HHSearch
36.94
12%
-12
- C3 -
-
3T7V
2
PYLB_METBF
A:
[59-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
L
N
C
F
I
Y
F
S
-
T
Y
--
C
K
N
Q
C
S
F
C
Y
Y
N
C
R
N
E
I
------
N
------
R
-
Y
-
R
L
T
M
-------------
E
E
----
I
K
E
T
C
-
K
T
L
K
G
--------------------------
A
--
G
F
--
H
M
V
D
L
T
-
M
-------
G
-
E
D
P
Y
Y
Y
E
D
--
P
-----
N
R
----
F
V
E
L
V
--
Q
I
V
K
----
E
E
L
-------------------
G
L
P
I
-----
M
I
S
P
G
L
M
D
-
N
A
T
L
L
K
A
R
E
K
G
A
--
N
F
L
----
A
L
Y
Q
E
T
Y
D
T
E
L
Y
R
K
L
RVGQS----
F
--------------
D
-------
G
R
V
N
A
R
R
F
A
K
Q
Q
----
G
---
Y
C
--------
V
E
D
G
--
I
L
T
G
V
-
G
-
N
D
I
E
-
S
T
I
L
S
L
R
G
M
S
---
T
N
D
-
P
D
M
V
R
V
M
T
-
F
L
P
Q
E
-
G
T
P
-----
L
E
GFR------
D
-
K
S
N
L
S
E
L
K
I
I
S
V
L
R
L
M
F
P
K
----------------------------
32
HHSearch
36.39
13%
11
- C3 -
-
3C8F
3
PFLA_ECOLI
A:
[14-208]
---------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
D
G
P
G
I
R
F
I
T
F
F
-
Q
G
--
C
L
M
R
C
L
Y
C
H
N
R
D
T
W
D
T
------
H
------
G
G
K
-
E
V
T
V
-------------
E
D
----
L
M
K
E
V
-
V
T
Y
R
H
---------
F
----------------
M
NA
S
G
--
G
G
V
T
A
S
-
G
-------
G
-
E
-
A
I
L
Q
----
A
-----
E
F
----
V
R
D
W
F
--
R
A
C
K
----
K
E
G
------------------
I
H
T
C
L
-----
D
T
N
G
F
V
R
R
Y
D
P
V
I
D
E
L
L
E
-
V
T
--
D
L
V
----
M
L
D
L
K
Q
M
N
D
-
E
I
H
Q
N
L
VGVS----
N
--------------
H
-------
R
T
L
E
F
A
K
Y
L
A
N
K
----
N
---
V
K
--------
V
W
I
R
Y
V
V
V
P
G
W
-
S
-
D
D
D
D
-
S
A
H
R
L
G
E
F
T
R
---
D
M
G
N
V
E
K
I
E
L
L
P
-
Y
H
E
L
G
-
K
H
K
-----------------------------------------------------------------
49
HHSearch
36.15
9%
-3
- C3 -
-
5EXJ
3
LIPA_MYCTU
A:
[92-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
F
L
I
G
G
-
D
Q
--
C
T
R
R
C
D
F
C
Q
I
D
T
G
K
P
----------------
A
-
E
L
D
R-------------
D
E
----
P
R
R
V
A
-
D
S
V
R
T
--------------------------
M
--
G
L
--
R
Y
A
T
V
T
-
G
-------
V
-
A
-
R
D
D
L
P
DGG
A
-----
W
L
----
Y
A
A
T
V
--
R
A
I
K
----
E
L
N
P
------------------
S
T
G
V
---
E
L
L
I
P
D
F
N
G
E
-
P
T
R
L
A
E
V
F
E
S
G
P
--
E
V
L
----
A
H
N
V
E
T
V
P
R
-
I
F
K
R
IRPAFT----
Y
--------------
R
-------
R
S
L
G
V
L
T
A
A
R
D
A
----
G
---
L
V
--------
T
K
S
N
L
I
--
L
G
L
-
G
-
E
T
S
D
-
E
V
R
T
A
L
G
D
L
R
---
D
A
G
-
C
D
I
V
T
I
T
Q
Y
L
R
P
S
A
R
H
H
P
-----
V
E
---------
R
W
V
K
P
E
E
F
V
Q
F
A
R
F
A
E
---------------------------------
43
HHSearch
35.95
13%
-5
- C3 -
-
5VSL
2
?
A:
[28-206]
------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
V
S
V
N
Y
H
F
T
-
R
Q
--
C
N
Y
K
C
G
F
C
F
H
T
A
K
T
S
F
-----------------
V
L
P
L
-------------
E
E
----
A
K
R
G
L
-
L
L
L
K
Q
--------------------------
A
--
G
L
--
E
K
I
N
F
S
-
G
-------
G
-
E
-
P
F
L
Q
D
---
R
G----
E
Y
----
L
G
K
L
V
--
R
F
C
K
----
E
E
L
A
------------------
L
P
S
V
---
S
I
V
S
N
G
S
L
I
R
-
E
R
W
F
K
D
Y
G
-
E
Y
--
L
D
I
L
----
A
I
S
C
D
S
F
D
E
-
Q
-------------
V
N
A
L
I
GRGQGKKN
H
V
E
-------
N
L
Q
K
L
R
R
W
C
R
D
Y
----
K
---
V
A
--------
F
K
I
N
S
V
I
N
R
F
N
-
V
-
D
E
---
D
M
N
E
H
I
K
A
L
S
---
P
V
R
-
W
----------------------------------------------------------------------------------
50
HHSearch
35.88
9%
-3
- C3 -
-
5EXK
4
LIPA_MYCTU
A:
[92-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
F
L
I
G
G
-
D
Q
--
C
T
R
R
C
D
F
C
Q
I
D
T
G
K
P
----------------
A
-
E
L
D
R-------------
D
E
----
P
R
R
V
A
-
D
S
V
R
T
--------------------------
M
--
G
L
--
R
Y
A
T
V
T
-
G
-------
V
-
A
-
R
D
D
L
P
DGG
A
-----
W
L
----
Y
A
A
T
V
--
R
A
I
K
----
E
L
N
P
------------------
S
T
G
V
---
E
L
L
I
P
D
F
N
G
E
-
P
T
R
L
A
E
V
F
E
S
G
P
--
E
V
L
----
A
H
N
V
E
T
V
P
R
-
I
FKRIRPAFT----
Y
--------------
R
-------
R
S
L
G
V
L
T
A
A
R
D
A
----
G
---
L
V
--------
T
K
S
N
L
I
--
L
G
L
-
G
-
E
T
S
D
-
E
V
R
T
A
L
G
D
L
R
---
D
A
G
-
C
D
I
V
T
I
T
Q
Y
L
R
P
S
A
R
H
H
P
-----
V
E
---------
R
W
V
K
P
E
E
F
V
Q
F
A
R
F
A
E
---------------------------------
44
HHSearch
34.43
13%
-5
- C3 -
-
5VSM
2
?
A:
[30-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
V
N
Y
H
F
T
-
R
Q
--
C
N
Y
K
C
G
F
C
F
H
T
A
K
T
S
F
-----------------
V
L
P
L
-------------
E
E
----
A
K
R
G
L
-
L
L
L
K
Q
--------------------------
A
--
G
L
--
E
K
I
N
F
S
-
G
-------
G
-
E
-
P
F
L
Q
D
---
R
G----
E
Y
----
L
G
K
L
V
--
R
F
C
K
----
E
E
L
A
------------------
L
P
S
V
---
S
I
V
S
N
G
S
L
I
R
-
E
R
W
F
K
D
Y
G
-
E
Y
--
L
D
I
L
----
A
I
S
C
D
S
F
D
E
-
Q
-------------
V
N
A
L
I
GRGQGKKN
H
V
E
-------
N
L
Q
K
L
R
R
W
C
R
D
Y
----
K
---
V
A
--------
F
K
I
N
S
V
I
N
R
F
N
-
V
-
D
E
---
D
M
N
E
H
I
K
A
L
S
---
P
V
R
-
W
----------------------------------------------------------------------------------