@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUF8: (2017-12-18 )
MKSAFKRFVQQSPSTVKDNVFAVVAYCPINNLANADLGYEWQYNASRNDSNTGNLNGVSYSAGPQLTASKEIAEKFPMYLQTLNLKLPNGQQLTAENMPDQIKEQIKSEIERQLAKGTPVPNFGENFVSSKATLVNDWLKHDGSKVTEIDYQKFLNYVAANQALKTVVAFDAVGVNGNTAISGETNLFGDSQNEYNNFTQWSWDHNSKTADGSGQDDTGLSWENYLNSNSSTANLLKDQLKMVNPIAYLNTTTDTAPYWYIRHGVLDRDTSFAMQMILYYAVTNDPKVKDTNFKLPYLTGHAGNYDVQEAFKWINEKLNTTQ
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------........---------.10.-........20.....-------...30........----------------------40........50.....------------...60...------------.....70-----........80......--..-------90...-----..-----...100-.....------..110.......120.......130------........140.......150-------........160.......170.......180....---...190.......200----------------....--------.....210.......220.......230.......240.-......250-..-.-----....260..-.....270.......280--------.........290.......300..-..-...310.......320------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
K
S
A
F
K
R
F
---------
V
Q
-Q-SPSTVKD
N
V
F
A
V
V
A
Y-------CPINNLANADLG
Y
----------------------
E
W
Q
YNASRNDSNTGNLN------------
G
V
SYSAGP------------QLT
A
S
K
E
-----
I
A
E
K
F
P
M
Y
L
Q
T
LNLKL--PN-------GQQL
T
-----
A
E-----NM
P
D
Q
I
-
K
E
Q
I
K
------
S
E
I
E
R
Q
L
AKGTPVPNF
G
E
N
F
V
S
S
K
-------
A
T
L
V
N
D
W
L
KHDGSKVT
E
I
D
Y
--------
Q
K
F
L
N
Y
V
A
A
N
Q
A
L
K
T
V
V
A
F
D
A
VGVNG
N
T
AISGETN---LFGDSQNEYNNF
T
Q
------------------
W
S
WD--------HNSKTADGSGQDDTG
L
S
W
E
N
YLNSNS
S
T
A
N
L
L
K
D
Q
L
K
MV-N
P
I
A
Y
LNTT-TD-T-----A
P
Y
W
Y
I
RHG-VLDR
D
T
S
F
A
M
Q
M
I
L
Y
Y
----------
A
VTNDPKVKDTNFKL
P
Y
LTGHAGN-Y
D
-
V
Q
E
A
F
K
W
I
N
E
KLNTTQ------------------------------
21
Fugue
72.56
32%
48
- C3 -
-
4J0D
4
?
A:
[22-491]
SMSNRLIFDADW
L
V
P
E
Q
V
Q
VAG
Q
A
I
Q
Y
Y
A
A
R
NIQYVQHPVAAIQ
V
L
N
V
F
V
P
A
A
Y
L
H
GSSVNGYQRA
T
A
P
I
L
M
P
N
TVGGYLPGPADDPQRVTWPTN
A
G
T
I
Q
Q
A
L
K
R
G
Y
V
V
V
A
A
G
I
R
G
RTTVDKSGQRVGQAP
A
F
I
V
D
M
K
A
A
I
R
Y
V
K
Y
N
Q
GRLPGDANR
I
I
T
N
G
T
S
A
G
G
A
T
S
A
L
A
G
A
S
G
N
S
A
Y
F
E
P
A
---------
L
T
-
A
L
G
A
A
P
A
T
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
Y
Q
P
V
A
------------
G
T
T
K
N
G
R
P
K
F
E
P
V
S
G
Q
L
T
V
E
E
Q
A
L
S
L
A
-----
L
K
A
Q
F
S
T
Y
L
N
Q
L
K
L
T
A
--
S
D
-------
G
T
H
L
T
L
N
EAG
M
G
-----
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
T
D
I
H
K
Y
-
A
G
F
V
V
T
-------------------
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
T
R
---
M
K
A
V
P
A
F
D
Q
L
D
L
T
-----
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
A
Q
L
A
D
----------------------
A
E
L
I
Q
A
I
-
N
P
L
S
Y
L
T
T
T
-
S
S
-
Q
V----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
H
G
Y
--
G
I
D
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
G
L
C
Q
---------------------------------
32
HHSearch
68.38
31%
14
- C3 -
-
4J0D
5
?
B:
[202-491]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
P
A
---------
L
T
A
L
-
G
A
A
P
A
T
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
Y
Q
P
V
A
GTTKNGRPKFEP
V
S
G
Q
L
T
V
E
------------
E
Q
A
L
S
L
A
-----
L
K
A
Q
F
S
T
Y
L
N
Q
L
K
L
T
A
--
S
D
-------
G
T
H
L
T
-----
L
N
EAGMG
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
-------------
T
-------
D
I
H
K
Y
A
G
F
V
V
T
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
---
T
R
M
K
A
V
P
A
F
D
Q
L
D
L
-----
T
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
----
A
------------------
Q
L
A
D
A
E
L
I
Q
A
I
-
N
P
L
S
Y
L
T
T
T
S
S
Q
-
V
-----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
--
H
G
Y
G
I
D
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
G
L
C
Q
---------------------------------
31
HHSearch
66.78
31%
14
- C3 -
-
4J0K
3
?
B:
[181-470]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
P
A
---------
L
T
A
L
-
G
A
A
P
A
T
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
Y
Q
P
V
A
GTTKNG
R
P
K
F
E
P
V
S
G
Q
L
T
V
E
------------
E
Q
A
L
S
L
A
-----
L
K
A
Q
F
S
T
Y
L
N
Q
L
K
L
T
A
--
S
D
-------
G
T
H
L
T
-----
L
N
EAGMG
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
-------------
T
-------
D
I
H
K
Y
A
G
F
V
V
T
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
---
T
R
M
K
A
V
P
A
F
D
Q
L
D
L
-----
T
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
----
A
------------------
Q
L
A
D
A
E
L
I
Q
A
I
-
N
P
L
S
Y
L
T
T
T
S
S
Q
-
V
-----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
--
H
G
Y
G
I
D
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
G
L
C
Q
---------------------------------
6
PsiBlast_PDB
64.71
29%
24
- C3 -
-
4J0D
3
?
A:
[213-487]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
A
T
--
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
Y
Q
P
V
A
------------
G
T
T
K
N
G
R
P
K
F
E
P
V
S
G
-----
Q
L
T
V
E
E
Q
A
L
S
L
A
L
K
A
Q
F
S
T
Y
L
N
Q
L
K
L
T
A
--
S
D
-------
G
T
H
L
T
L
N
EAG
M
G
-----
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
T
D
I
H
K
Y
A
G
F
V
V
T
--------------------
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
T
---
R
M
K
A
V
P
A
F
D
Q
L
D
L
T
-----
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
A
------------------
Q
L
A
D
A
E
L
----
I
Q
A
I
-
N
P
L
S
Y
L
T
T
T
-
S
S
Q
V
-----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
H
G
Y
G
I
D
--
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
-------------------------------------
10
PsiBlast_PDB
64.67
29%
27
- C3 -
-
3WA7
1
?
A:
[191-465]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
A
T
--
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
Y
Q
P
V
A
------------
G
T
T
K
N
G
R
P
K
F
E
P
V
S
G
-----
Q
L
T
V
E
E
Q
A
L
S
L
A
L
K
A
Q
F
S
T
Y
L
N
Q
L
Q
L
T
A
--
S
D
-------
G
T
H
L
T
L
N
EAG
M
G
-----
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
T
D
I
H
K
Y
A
G
F
V
V
T
--------------------
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
T
R
M
---
K
A
V
P
A
F
D
Q
L
D
L
T
-----
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
A
------------------
Q
L
A
D
A
E
L
----
I
Q
A
I
-
N
P
L
S
Y
L
T
T
T
-
S
S
Q
V
-----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
H
G
Y
G
I
D
--
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
-------------------------------------
2
PsiBlast_PDB
64.44
29%
22
- C3 -
-
3WA6
-
?
A:
[191-465]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
A
T
--
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
Y
Q
P
V
A
------------
G
T
T
K
N
G
R
P
K
F
E
P
V
S
G
-----
Q
L
T
V
E
E
Q
A
L
S
L
A
L
K
A
Q
F
S
T
Y
L
N
Q
L
Q
L
T
A
--
S
D
-------
G
T
H
L
T
L
N
EAG
M
G
-----
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
T
D
I
H
K
Y
A
G
F
V
V
T
--------------------
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
T
---
R
M
K
A
V
P
A
F
D
Q
L
D
L
T
-----
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
A
------------------
Q
L
A
D
A
E
L
----
I
Q
A
I
-
N
P
L
S
Y
L
T
T
T
-
S
S
Q
V
-----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
H
G
Y
G
I
D
--
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
-------------------------------------
7
PsiBlast_PDB
64.41
29%
22
- C3 -
-
4J0H
4
?
A:
[213-487]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
A
T
--
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
Y
Q
P
V
A
------------
G
T
T
K
N
G
R
P
K
F
E
P
V
S
G
-----
Q
L
T
V
E
E
Q
A
L
S
L
A
L
K
A
Q
F
S
T
Y
L
N
Q
L
K
L
T
A
--
S
D
-------
G
T
H
L
T
L
N
EAG
M
G
-----
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
T
D
I
H
K
Y
A
G
F
V
V
T
--------------------
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
T
---
R
M
K
A
V
P
A
F
D
Q
L
D
L
T
-----
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
A
------------------
Q
L
A
D
A
E
L
----
I
Q
A
I
-
N
P
L
S
Y
L
T
T
T
-
S
S
Q
V
-----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
H
G
Y
G
I
D
--
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
-------------------------------------
9
PsiBlast_PDB
63.92
29%
27
- C3 -
-
4J0J
1
?
A:
[213-487]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
A
T
--
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
Y
Q
P
V
A
------------
G
T
T
K
N
G
R
P
K
F
E
P
V
S
G
-----
Q
L
T
V
E
E
Q
A
L
S
L
A
L
K
A
Q
F
S
T
Y
L
N
Q
L
K
L
T
A
--
S
D
-------
G
T
H
L
T
L
N
EAG
M
G
-----
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
T
D
I
H
K
Y
A
G
F
V
V
T
--------------------
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
T
---
R
M
K
A
V
P
A
F
D
Q
L
D
L
T
-----
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
A
------------------
Q
L
A
D
A
E
L
----
I
Q
A
I
-
N
P
L
S
Y
L
T
T
T
-
S
S
Q
V
-----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
H
G
Y
G
I
D
--
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
-------------------------------------
4
PsiBlast_PDB
63.76
29%
-2
- C3 -
-
4J0K
2
?
A:
[192-466]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
A
T
--
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
-------------------------FEP
V
S
G
------
Q
L
T
V
E
E
Q
A
L
S
L
A
L
K
A
Q
F
S
T
Y
L
N
Q
L
K
L
T
A
--
S
D
-------
G
T
H
L
T
L
N
EAG
M
G
-----
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
T
D
I
H
K
Y
A
G
F
V
V
T
--------------------
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
T
---
R
M
K
A
V
P
A
F
D
Q
L
D
L
T
-----
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
A
------------------
Q
L
A
D
A
E
L
----
I
Q
A
I
-
N
P
L
S
Y
L
T
---
S
S
Q
V
-----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
H
G
Y
G
I
D
--
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
-------------------------------------
1
PsiBlast_PDB
63.71
29%
20
- C3 -
-
4JUI
6
?
A:
[192-466]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
A
T
--
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
Y
Q
P
V
A
------------
G
T
T
K
N
G
R
P
K
F
E
P
V
S
G
-----
Q
L
T
V
E
E
Q
A
L
S
L
A
L
K
A
Q
F
S
T
Y
L
N
Q
L
K
L
T
A
--
S
D
-------
G
T
H
L
T
L
N
EAG
M
G
-----
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
T
D
I
H
K
Y
A
G
F
V
V
T
--------------------
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
T
---
R
M
K
A
V
P
A
F
D
Q
L
D
L
T
-----
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
A
------------------
Q
L
A
D
A
E
L
----
I
Q
A
I
-
N
P
L
S
Y
L
T
T
T
-
S
S
Q
V
-----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
H
G
Y
G
I
D
--
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
-------------------------------------
5
PsiBlast_PDB
62.49
29%
16
- C3 -
-
4J0C
2
?
A:
[213-487]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
A
T
--
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
-------------------------S
G
----------
Q
L
T
V
E
E
Q
A
L
S
L
A
L
K
A
Q
F
S
T
Y
L
N
Q
L
K
L
T
A
--
S
D
-------
G
T
H
L
T
L
N
EAG
M
G
-----
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
T
D
I
H
K
Y
A
G
F
V
V
T
--------------------
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
T
---
R
M
K
A
V
P
A
F
D
Q
L
D
L
T
-----
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
A
------------------
Q
L
A
D
A
E
L
----
I
Q
A
I
-
N
P
L
S
Y
L
T
T
T
-
S
S
Q
V
-----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
H
G
Y
G
I
D
--
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
-------------------------------------
8
PsiBlast_PDB
62.11
29%
16
- C3 -
-
4J0I
3
?
A:
[213-487]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
A
T
--
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
-------------------------S
G
----------
Q
L
T
V
E
E
Q
A
L
S
L
A
L
K
A
Q
F
S
T
Y
L
N
Q
L
K
L
T
A
--
S
D
-------
G
T
H
L
T
L
N
EAG
M
G
-----
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
T
D
I
H
K
Y
A
G
F
V
V
T
--------------------
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
T
---
R
M
K
A
V
P
A
F
D
Q
L
D
L
T
-----
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
A
------------------
Q
L
A
D
A
E
L
----
I
Q
A
I
-
N
P
L
S
Y
L
T
T
T
-
S
S
Q
V
-----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
H
G
Y
G
I
D
--
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
-------------------------------------
3
PsiBlast_PDB
61.67
29%
14
- C3 -
-
4J0G
2
?
A:
[192-466]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
A
T
--
D
D
I
F
A
V
S
A
Y
-------
C
P
I
H
N
L
E
H
A
D
M
A
Y
----------------------
E
W
Q
F
N
G
I
N
D
W
H
R
Y
------------------------V
S
G
---------
Q
L
T
V
E
E
Q
A
L
S
L
A
L
K
A
Q
F
S
T
Y
L
N
Q
L
K
L
T
A
--
S
D
-------
G
T
H
L
T
L
N
EAG
M
G
-----
S
F
R
D
V
V
-
R
Q
L
L
I
------
S
S
A
Q
T
A
F
D
Q
G
T
D
I
H
K
Y
A
G
F
V
V
T
--------------------
G
N
Q
V
T
D
L
D
L
--------
S
A
Y
L
K
S
L
T
---
R
M
K
A
V
P
A
F
D
Q
L
D
L
T
-----
S
P
E
N
N
---
L
F
G
D
A
T
A
K
A
K
H
F
T
A
------------------
L
A
Q
T
--------
R
S
T
V
T
A
------------------
Q
L
A
D
A
E
L
----
I
Q
A
I
-
N
P
L
S
Y
L
T
T
T
-
S
S
Q
V
-----
A
K
H
W
R
I
R
H
G
-
A
A
D
R
D
T
S
F
A
I
P
I
I
L
A
I
----------
M
L
E
N
H
G
Y
G
I
D
--
F
A
L
P
W
D
I
P
H
S
G
D
-
Y
D
-
L
G
D
L
F
S
W
I
D
-------------------------------------
12
PsiBlast_PDB
43.54
33%
-154
- C3 -
-
2MLB
-
?
A:
[1-36]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
T
I
N
I
T
L
--
P
D
-------
G
K
T
L
T
-----
L
T
-----
V
T
P
E
F
T
-
V
K
E
L
A
------
E
E
I
A
R
R
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
38.05
18%
-75
- C3 -
-
3WI3
16
SLD3_YEAST
A:
[8-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
D
P
K
E
Y
---------
I
E
-
S
-
K
Y
Y
D
A
L
F
S
I
H
T
P
L
A
Y
-------
F
V
K
S
N
L
V
R
L
K
N
T
C
----------------------
R
T
K
Y
G
S
D
-----------------------------
S
------------
Y
K
I
A
Y
Q
A
-----
M
L
Q
K
F
--
L
L
S
I
V
Q
F
K
D
--
R
H
-------
D
N
R
L
L
-----
L
E
-----
P
F
S
S
P
I
-
A
D
E
K
R
------
K
N
C
L
T
K
F
V
I
Q
D
E
N
K
N
-----------------------------
S
S
T
I
A
D
L
--------
C
V
V
L
K
--
S
R
E
I
K
L
Q
I
L
L
L
L
E
I
I
G
L
N
D
L
------------------------
D
------------------
W
N
F
R
--------
D
F
D
Y
C
E
Q
L
D
L
Y
L
D
R
A
C
I
L
D
I
L
L
S
S
E
T
G
T
I
Q
E
H
K
K
N
----------------------------------
I
L
D
K
S
K
E
A
S
L
V
G
F
I
N
Y
----------
V
------------
L
I
P
Y
F
-----
N
-
K
K
-
V
P
H
A
V
E
F
I
I
Q
K
L
K
G
P
S
------------------------------
22
Fugue
36.08
18%
30
- C3 -
-
4YB8
-
?
A:
[1-464]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
L
E
R
L
F
N
PS
A
I
A
V
V
G
A
S
-
K
-
D
P
S
K
I
G
S
Q
I
L
R
N
L
L
S
Y
GFK
G
K
V
Y
P
I
N
P
T
A
D
E
L
M
G
L
KCYPKVSDVPDKVDVAVISVPS
D
K
V
L
G
V
I
D
D
C
G
K
A
G
V
K
F
------------
A
V
V
I
T
S
G
F
------------
K
E
V
G
N
E
E
-----
L
E
E
E
L
V
R
R
A
H
S
Y
G
M
R
V
L
G
P
N
IF
G
Y
L
Y
A
P
A
R
L
N
-----
A
T
-----
F
G
P
K
D
V
-
L
S
G
N
V
A
F
I
S
QS
G
A
L
G
I
A
L
M
G
Y
T
V
V
E
N
I
G
I
S
S
I
V
S
V
GNKADLD
D
V
D
L
L
D
F
F
D
K
D
P
N
T
G
V
I
M
I
Y
LEGIAPGR
G
R
M
F
I
D
V
A
S
R
V
S
L
R
K
P
I
I
V
I
K
A
G
R
T
E
V
G
A
R
A
A
A
S
H
T
GS
I
A
G
S
V
A
I
Y
E
S
A
F
K
Q
S
G
I
L
M
A
KS
V
E
D
A
F
D
W
T
K
A
L
S
W
N
PIPEGER
L
I
V
L
T
N
G
G
G
A
G
V
Q
S
T
D
T
F
A
D
N
G
I
Y
L
S
K
P
P
E
S
L
I
Q
E
I
K
K
F
V
-
P
P
F
A
S
F
A
N
P
-
I
D
-
I
TGMAP
D
D
W
Y
Y
M
G
T
L
-
A
A
L
K
N
P
D
V
D
A
L
T
V
L
Y
C
Q
T
AVTT
P
I
G
V
A
K
G
I
V
D
A
I
K
E
A
G
N
S
K
P
V
T
V
G
M
V
G
G
-
P
E
-
V
A
E
A
V
S
F
L
N
K
Q
R
I
A
A
Y
PT
P
E
R
A
S
S
A
M
S
A
L
Y
A
Y
A
R
A
R
S
Y
V
M
K
S
L
AVR
28
Fugue
33.75
16%
40
- C3 -
-
4P5W
-
CMC2_HUMAN
A:
[31-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKRA
D
P
A
E
L
R
T
I
---------
F
L
-
K
-
Y
A
S
I
E
K
N
G
E
F
F
M
-----------
S
P
N
D
F
V
T
R
Y
L
N
I
--------------------------
F
S
Q
P
N
P
K
T
V
E
L
L
S
------------
G
V
V
D
Q
T
K
D
------------
G
L
I
S
F
Q
E
-----
F
V
A
F
E
S
V
L
C
A
--------
P
D
-------
A
L
F
M
V
-----
A
F
-----
Q
L
F
D
K
A
G
K
G
E
V
T
------
F
E
D
V
K
Q
V
F
G
Q
T
T
I
H
Q
H
I
P
-
F
N
W
D
S
-------
E
F
V
Q
L
H
F
G
K
E
R
K
R
H
L
T
Y
A
E
F
--------
T
Q
F
L
L
E
I
Q
L
E
H
A
K
Q
A
F
V
Q
R
D
N
A
R
T
G
R
V
T
A
I
D
F
R
D
I
---
M
V
T
I
R
P
H
V
---
L
T
P
------------------
F
V
E
E
--------
C
L
V
A
A
A
G
G
T
T
S
H
Q
V
S
F
S
Y
F
N
G
F
N
S
L
L
N
N
M
E
L
I
R
K
I
Y
S
T
L
A
G
T
R
K
D
V
E
V
T
-
K
E
-
E
-----
F
V
L
A
A
Q
K
F
G
Q
V
T
P
M
E
V
D
I
L
F
Q
L
A
D
L
Y
----------
E
P
R
G
R
M
T
L
A
D
I
E
R
I
A
P
P
N
P
D
H
V
G
G
-
Y
K
L
A
V
A
T
F
A
G
I
E
N
K
F
G
L
Y
L
------------------------------
43
HHSearch
31.44
16%
-84
- C3 -
-
1AUO
-
EST2_PSEFL
B:
[162-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
L
H
G
-
Q
Y
D
D
V
V
Q
N
A
M
G
R
S
A
F
E
----------
H
L
K
S
--
R
G
V
T
V
T
W
Q
E
Y
P
M
-
G
H
E
V
L
P
Q
E
-
I
H
D
I
G
A
W
L
A
A
R
L
G
---------------------------------
42
HHSearch
29.41
16%
-73
- C3 -
-
1AUR
1
EST2_PSEFL
A:
[162-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
L
H
G
-
Q
Y
D
D
V
V
Q
N
A
M
G
R
S
A
F
E
----------
H
L
K
S
--
R
G
V
T
V
T
W
Q
E
Y
P
M
-
G
H
E
V
L
P
Q
E
-
I
H
D
I
G
A
W
L
A
A
R
L
G
---------------------------------
44
HHSearch
28.81
22%
-83
- C3 -
-
4FHZ
1
?
A:
[210-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
H
G
-
D
A
D
P
V
V
P
F
A
D
M
S
L
A
G
E
----------
A
L
A
E
--
A
G
F
T
T
Y
G
H
V
M
K
G
T
G
H
G
I
A
P
D
G
-
L
S
V
A
L
A
F
L
K
E
R
L
P
---------------------------------