@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUG4: (2017-12-18 )
MSILSWDDFEDDSQKPAAPEHKSAPVNPEKTPDSQNVSAAQPSSQSMAAPQSTGTHSVRSTNPTDSMARASEALEHLDVAPGLEELEMGAQRVQVDDKAMINCRADLNQLVPFKYEWAWQKYLDGCANHWMPQEVNMNHDIALWKSENGLTEDERTIVMRSLGFFSTADSLVANNLVLAIYRHITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEVFNMYREIPSVARKAAWGLKYTQSLSDPTFHTGTPENDQRLLRNLIAFYCVLEGIFFYCGFTQILSMGRRNKMNGVAEQFQYILRDESMHLNFGIDMINQIKIENPHLWTAEFQQEVIQMILEGTMLEIEYARDTMPRGVLGMNASMMEEYLKFICNRRLSQLGLPEQFAGVTNPFAWMSEMMDLRKEKNFFETRVTDYQTGGALSW
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.-......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......---220-.........230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSILSWDDFEDDSQKPAAPEHKSAPVNPEKTPDSQNVSAAQPSSQSMAAPQSTGTHSVRSTNP
T
D
S
M
A
R
A
S
E
A
L
E
HLDVAP
G
L
E
E
L
E
M
G
A
Q
R
VQVDD
K
A
M
I
N
C-R
A
D
L
N
QLVPFK
Y
E
W
A
W
Q
K
Y
L
D
G
C
A
NHWMPQEVNMNH
D
I
A
L
W
KSENGLT
E
D
E
R
T
I
V
M
R
SLGFFS
T
A
D
S
L
V
A
N
N
L
V
L
A
I
Y
R
HIT
N
P
E
C
R
Q
Y
I
L
R
Q
A
F
E
E
A
I
H
T
H
A
Y
Q
Y
C
I
E
SLGMD
E
G
---
E
---
V
F
N
M
Y
R
E
I
P
S
V
A
R
K
A
AWGLK
Y
T
QSLSDPTFHTGTPE
N
D
Q
R
L
L
R
N
L
I
A
F
Y
C
V
L
E
G
I
F
F
Y
C
G
F
T
Q
I
L
SMGRRNKM
N
G
V
A
E
Q
F
Q
Y
I
LRDE
S
M
H
L
N
F
G
I
D
M
I
N
Q
I
KIENPHL
W
T
A
E
F
Q
Q
E
V
I
Q
M
I
LEG
T
M
L
E
I
E
YARDTMPRGVLGM
N
A
S
M
M
E
E
Y
L
K
F
I
C
N
R
R
L
S
QLGL
P
E
Q
FAGVT
N
P
F
A
W
M
S
E
M
M
D
L
R
K
EK
N
F
F
E
T
RVTDYQTGGALSW
2
PsiBlast_PDB
91.57
54%
-55
- C4 -
-
1SYY
-
RIR2_CHLTR
A:
[6-318]
-------------------------------------------------------------------------------------
L
D
G
K
Q
K
R
V
N
L
N
S
K
R
L
V
N
C
N
Q
V
D
V
N
Q
L
V
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
L
G
L
D
E
K
---
E
---
I
F
N
A
Y
N
E
R
A
A
I
K
A
K
D
D
F
Q
M
E
I
T
G
K
V
L
D
P
N
F
R
T
D
S
V
E
G
L
Q
E
F
V
K
N
L
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
N
P
E
I
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
K
P
I
Y
H
-
T
K
N
P
F
P
W
M
----------------------------
1
PsiBlast_PDB
91.29
54%
-54
- C4 -
-
2ANI
-
RIR2_CHLTR
A:
[6-318]
-------------------------------------------------------------------------------------
L
D
G
K
Q
K
R
V
N
L
N
S
K
R
L
V
N
C
N
Q
V
D
V
N
Q
L
V
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
Y
L
Y
I
C
E
S
L
G
L
D
E
K
---
E
---
I
F
N
A
Y
N
E
R
A
A
I
K
A
K
D
D
F
Q
M
E
I
T
G
K
V
L
D
P
N
F
R
T
D
S
V
E
G
L
Q
E
F
V
K
N
L
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
N
P
E
I
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
K
P
I
Y
H
-
T
K
N
P
F
P
W
M
----------------------------
22
PsiBlast_CBE
90.12
54%
-44
- C4 -
-
4M1I
1
RIR2_CHLTR
C:
[26-347]
-------------------------------------------------------------------------------------
L
D
G
K
Q
K
R
V
N
L
N
S
K
R
L
V
N
C
N
Q
V
D
V
N
Q
L
V
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
L
G
L
D
E
K
---
E
---
I
F
N
A
Y
N
E
R
A
A
I
K
A
K
D
D
F
Q
M
E
I
T
G
K
V
L
D
P
N
F
R
T
D
S
V
E
G
L
Q
E
F
V
K
N
L
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
N
P
E
I
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
K
P
I
Y
H
-
T
K
N
P
F
P
W
M
S
E
T
I
D
L
N
K
E
-------------------
4
PsiBlast_PDB
89.52
54%
-47
- C4 -
-
4D8G
-
RIR2_CHLTR
A:
[26-338]
-------------------------------------------------------------------------------------
L
D
G
K
Q
K
R
V
N
L
N
S
K
R
L
V
N
C
N
Q
V
D
V
N
Q
L
V
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
L
G
L
D
E
K
---
E
---
I
F
N
A
Y
N
E
R
A
A
I
K
A
K
D
D
F
Q
M
E
I
T
G
K
V
L
D
P
N
F
R
T
D
S
V
E
G
L
Q
E
F
V
K
N
L
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
N
P
E
I
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
K
P
I
Y
H
-
T
K
N
P
F
P
W
M
----------------------------
3
PsiBlast_PDB
89.42
54%
-47
- C4 -
-
4D8F
3
RIR2_CHLTR
A:
[26-340]
-------------------------------------------------------------------------------------
L
D
G
K
Q
K
R
V
N
L
N
S
K
R
L
V
N
C
N
Q
V
D
V
N
Q
L
V
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
L
G
L
D
E
K
---
E
---
I
F
N
A
Y
N
E
R
A
A
I
K
A
K
D
D
F
Q
M
E
I
T
G
K
V
L
D
P
N
F
R
T
D
S
V
E
G
L
Q
E
F
V
K
N
L
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
N
P
E
I
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
K
P
I
Y
H
-
T
K
N
P
F
P
W
M
S
E
--------------------------
29
PsiBlast_CBE
89.20
54%
-43
- C4 -
-
4D8F
3
RIR2_CHLTR
B:
[26-344]
-------------------------------------------------------------------------------------
L
D
G
K
Q
K
R
V
N
L
N
S
K
R
L
V
N
C
N
Q
V
D
V
N
Q
L
V
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
L
G
L
D
E
K
---
E
---
I
F
N
A
Y
N
E
R
A
A
I
K
A
K
D
D
F
Q
M
E
I
T
G
K
V
L
D
P
N
F
R
T
D
S
V
E
G
L
Q
E
F
V
K
N
L
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
N
P
E
I
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
K
P
I
Y
H
-
T
K
N
P
F
P
W
M
S
E
T
I
D
L
----------------------
6
PsiBlast_PDB
88.62
54%
-39
- C4 -
-
4M1I
1
RIR2_CHLTR
A:
[26-347]
-------------------------------------------------------------------------------------
L
D
G
K
Q
K
R
V
N
L
N
S
K
R
L
V
N
C
N
Q
V
D
V
N
Q
L
V
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
L
G
L
D
E
K
---
E
---
I
F
N
A
Y
N
E
R
A
A
I
K
A
K
D
D
F
Q
M
E
I
T
G
K
V
L
D
P
N
F
R
T
D
S
V
E
G
L
Q
E
F
V
K
N
L
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
N
P
E
I
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
K
P
I
Y
H
-
T
K
N
P
F
P
W
M
S
E
T
I
D
L
N
K
E
-------------------
23
PsiBlast_CBE
88.50
54%
-44
- C4 -
-
4M1I
1
RIR2_CHLTR
B:
[26-340]
-------------------------------------------------------------------------------------
L
D
G
K
Q
K
R
V
N
L
N
S
K
R
L
V
N
C
N
Q
V
D
V
N
Q
L
V
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
L
G
L
D
E
K
---
E
---
I
F
N
A
Y
N
E
R
A
A
I
K
A
K
D
D
F
Q
M
E
I
T
G
K
V
L
D
P
N
F
R
T
D
S
V
E
G
L
Q
E
F
V
K
N
L
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
N
P
E
I
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
K
P
I
Y
H
-
T
K
N
P
F
P
W
M
S
E
--------------------------
41
HHSearch
86.03
55%
-
- C4 -
-
4M1H
-
RIR2_CHLTR
D:
[4-328]
-----------------------------------------------------------------------------------
D
I
L
D
G
K
Q
K
R
V
N
L
N
S
K
R
L
V
N
C
N
Q
V
D
V
N
Q
L
V
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
-
D
R
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
L
G
L
D
E
K
---
E
---
I
F
N
A
Y
N
E
R
A
A
I
K
A
K
D
D
F
Q
M
E
I
T
G
K
V
L
D
P
N
F
R
T
D
S
V
E
G
L
Q
E
F
V
K
N
L
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
N
P
E
I
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
K
P
I
Y
H
-
T
K
N
P
F
P
W
M
S
E
T
I
D
L
N
K
E
K
------------------
40
HHSearch
85.85
55%
-
* C4 *
-
4M1H
-
RIR2_CHLTR
B:
[4-328]
-----------------------------------------------------------------------------------
D
I
L
D
G
K
Q
K
R
V
N
L
N
S
K
R
L
V
N
C
N
Q
V
D
V
N
Q
L
V
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
-
D
R
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
L
G
L
D
E
K
---
E
---
I
F
N
A
Y
N
E
R
A
A
I
K
A
K
D
D
F
Q
M
E
I
T
G
K
V
L
D
P
N
F
R
T
D
S
V
E
G
L
Q
E
F
V
K
N
L
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
N
P
E
I
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
K
P
I
Y
H
-
T
K
N
P
F
P
W
M
S
E
T
I
D
L
N
K
E
K
------------------
5
PsiBlast_PDB
83.67
54%
-
- C4 -
-
4M1H
-
RIR2_CHLTR
A:
[6-322]
-------------------------------------------------------------------------------------
L
D
G
K
Q
K
R
V
N
L
N
S
K
R
L
V
N
C
N
Q
V
D
V
N
Q
L
V
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
L
G
L
D
E
K
---
E
---
I
F
N
A
Y
N
E
R
A
A
I
K
A
K
D
D
F
Q
M
E
I
T
G
K
V
L
D
P
N
F
R
T
D
S
V
E
G
L
Q
E
F
V
K
N
L
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
N
P
E
I
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
K
P
I
Y
H
-
T
K
N
P
F
P
W
M
S
E
T
I
------------------------
48
HHSearch
72.17
30%
-82
- C4 -
-
1H0O
-
RIR2_MOUSE
A:
[65-352]
-------------------------------------------------------------------------------------------
N
P
S
V
E
D
E
P
L
L
R
E
-
N
P
R
R
F
V
V
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
---
A
L
K
P
D
E
R
H
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
N
E
N
L
V
E
R
F
S
Q
E
V
Q
V
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
E
R
E
Y
---
L
F
N
A
I
E
T
M
P
C
V
K
K
K
A
D
W
A
L
R
W
I
G
D
K
E
------------
A
T
Y
G
E
R
V
V
A
-
F
A
A
V
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
H
L
V
H
K
-
P
A
------
E
Q
R
V
R
E
I
I
T
N
A
V
R
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
I
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
N
K
I
F
R
-
V
E
N
P
F
D
F
M
E
---------------------------
19
PsiBlast_PDB
71.78
28%
-81
- C4 -
-
3VPN
-
RIR2_HUMAN
A:
[3-286]
----------------------------------------------------------------------------------------------
V
E
D
E
P
L
L
R
E
-
N
P
R
R
F
V
I
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
D
V
D
L
S
K
D
I
Q
H
W
E
S
---
L
K
P
E
E
R
Y
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
N
E
N
L
V
E
R
F
S
Q
E
V
Q
I
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
---
E
R
E
F
L
F
N
A
I
E
T
M
P
C
V
K
K
K
A
D
W
A
L
R
W
---
I
G
D
K
E
A
T
Y
G
---------
E
R
V
V
A
F
A
A
V
-
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
-------
H
L
V
H
K
P
S
E
E
R
V
R
E
I
I
I
N
A
V
R
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
I
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
S
K
V
F
R
-
V
E
N
P
F
D
F
M
----------------------------
9
PsiBlast_PDB
71.66
29%
-78
- C4 -
-
1H0N
-
RIR2_MOUSE
A:
[65-352]
-------------------------------------------------------------------------------------------
N
P
S
V
E
D
E
P
L
L
R
E
-
N
P
R
R
F
V
V
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
A
---
L
K
P
D
E
R
H
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
N
E
N
L
V
E
R
F
S
Q
E
V
Q
V
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
---
E
R
E
Y
L
F
N
A
I
E
T
M
P
C
V
K
K
K
A
D
W
A
L
R
W
---
I
G
D
K
E
A
T
Y
G
---------
E
R
V
V
A
F
A
A
V
-
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
-------
H
L
V
H
K
P
A
E
Q
R
V
R
E
I
I
T
N
A
V
R
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
I
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
N
K
I
F
R
-
V
E
N
P
F
D
F
M
-
E
--------------------------
10
PsiBlast_PDB
71.28
29%
-82
- C4 -
-
1H0O
-
RIR2_MOUSE
A:
[65-352]
-------------------------------------------------------------------------------------------
N
P
S
V
E
D
E
P
L
L
R
E
-
N
P
R
R
F
V
V
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
A
---
L
K
P
D
E
R
H
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
N
E
N
L
V
E
R
F
S
Q
E
V
Q
V
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
---
E
R
E
Y
L
F
N
A
I
E
T
M
P
C
V
K
K
K
A
D
W
A
L
R
W
---
I
G
D
K
E
A
T
Y
G
---------
E
R
V
V
A
F
A
A
V
-
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
-------
H
L
V
H
K
P
A
E
Q
R
V
R
E
I
I
T
N
A
V
R
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
I
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
N
K
I
F
R
-
V
E
N
P
F
D
F
M
-
E
--------------------------
18
PsiBlast_PDB
70.84
28%
-80
- C4 -
-
3VPO
-
RIR2_HUMAN
A:
[3-286]
----------------------------------------------------------------------------------------------
V
E
D
E
P
L
L
R
E
-
N
P
R
R
F
V
I
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
Q
V
D
L
S
K
D
I
Q
H
W
E
S
---
L
K
P
E
E
R
Y
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
N
E
N
L
V
E
R
F
S
Q
E
V
Q
I
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
---
E
R
E
F
L
F
N
A
I
E
T
M
P
C
V
K
K
K
A
D
W
A
L
R
W
---
I
G
D
K
E
A
T
Y
G
---------
E
R
V
V
A
F
A
A
V
-
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
-------
H
L
V
H
K
P
S
E
E
R
V
R
E
I
I
I
N
A
V
R
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
I
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
S
K
V
F
R
-
V
E
N
P
F
D
F
M
----------------------------
11
PsiBlast_PDB
70.84
29%
-80
- C4 -
-
1W68
1
RIR2_MOUSE
A:
[68-348]
----------------------------------------------------------------------------------------------
V
E
D
E
P
L
L
R
E
-
N
P
R
R
F
V
V
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
A
---
L
K
P
D
E
R
H
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
N
E
N
L
V
E
R
F
S
Q
E
V
Q
V
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
---
E
R
E
Y
L
F
N
A
I
E
T
M
P
C
V
K
K
K
A
D
W
A
L
R
W
---
I
G
D
K
E
A
T
Y
G
---------
E
R
V
V
A
F
A
A
V
-
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
-------
H
L
V
H
K
P
A
E
Q
R
V
R
E
I
I
T
N
A
V
R
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
I
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
N
K
I
F
R
-
V
E
N
P
F
-------------------------------
17
PsiBlast_PDB
70.26
28%
-79
- C4 -
-
3OLJ
-
RIR2_HUMAN
A:
[3-286]
----------------------------------------------------------------------------------------------
V
E
D
E
P
L
L
R
E
-
N
P
R
R
F
V
I
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
S
---
L
K
P
E
E
R
Y
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
N
E
N
L
V
E
R
F
S
Q
E
V
Q
I
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
---
E
R
E
F
L
F
N
A
I
E
T
M
P
C
V
K
K
K
A
D
W
A
L
R
W
---
I
G
D
K
E
A
T
Y
G
---------
E
R
V
V
A
F
A
A
V
-
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
-------
H
L
V
H
K
P
S
E
E
R
V
R
E
I
I
I
N
A
V
R
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
I
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
S
K
V
F
R
-
V
E
N
P
F
D
F
M
----------------------------
20
PsiBlast_PDB
70.15
28%
-81
- C4 -
-
3VPM
-
RIR2_HUMAN
A:
[3-286]
----------------------------------------------------------------------------------------------
V
E
D
E
P
L
L
R
E
-
N
P
R
R
F
V
I
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
A
V
D
L
S
K
D
I
Q
H
W
E
S
---
L
K
P
E
E
R
Y
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
N
E
N
L
V
E
R
F
S
Q
E
V
Q
I
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
---
E
R
E
F
L
F
N
A
I
E
T
M
P
C
V
K
K
K
A
D
W
A
L
R
W
---
I
G
D
K
E
A
T
Y
G
---------
E
R
V
V
A
F
A
A
V
-
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
-------
H
L
V
H
K
P
S
E
E
R
V
R
E
I
I
I
N
A
V
R
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
I
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
S
K
V
F
R
-
V
E
N
P
F
D
F
M
----------------------------
13
PsiBlast_PDB
70.11
29%
-81
- C4 -
-
1XSM
-
RIR2_MOUSE
A:
[65-352]
-------------------------------------------------------------------------------------------
N
P
S
V
E
D
E
P
L
L
R
E
-
N
P
R
R
F
V
V
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
A
---
L
K
P
D
E
R
H
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
N
E
N
L
V
E
R
F
S
Q
E
V
Q
V
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
---
E
R
E
Y
L
F
N
A
I
E
T
M
P
C
V
K
K
K
A
D
W
A
L
R
W
---
I
G
D
K
E
A
T
Y
G
---------
E
R
V
V
A
F
A
A
V
-
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
-------
H
L
V
H
K
P
A
E
Q
R
V
R
E
I
I
T
N
A
V
R
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
I
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
N
K
I
F
R
-
V
E
N
P
F
D
F
M
-
E
--------------------------