@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUQ0: (2017-12-19 )
MTVKILAVDMDGTFLNSKKQYNKARFLKQYEQLKQNNIRFVVASGNQLAKLVTYFPEINHEIAFIAENGAHVVDAGQELAFAHLSKEQFIEILNAIDPVYTSKMVICGKQSAYVHSSMNAEDYAKVARYFEKLTVIDDFYALDDLVCKITFTAQENESFTIFEHFQKQSFVKDKVLVPVSSGFNFIDLILPDQHKAHGLKLLLQKWQVQPDQVVAIGDNNNDIQMIKAAGYGFAVEALKSVTPYTTANNEQEGALQVIDLVLQHQPPFA
Atome Classification :
(20 SA)
.........10.......-.20........30........40........50------------.......----.------60....-....70.-..-.....80........90-........-100...-.--...110.......120---.......130.--.----------------.--.....140-----.......150.......160.......170.......180.-.-------.....190.......200.......210.......220.....----..230.----..----..----..240.....-..250.......260.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
V
K
I
L
A
VDMDGTFLN
S
K
-
K
Q
Y
N
K
A
R
F
L
K
Q
Y
E
Q
L
K
QN
N
I
R
F
V
VASG
N
Q
L
A
K
L
------------
V
T
Y
FPEI----N------
H
E
I
A
F
I
-AENG
A
H
V
-VD-AG
Q
E
L
A
F
A
HL
S
K
E
Q
F
I
E
-
I
L
N
AIDPV-YT
S
K
M
V
-
I
--CGKQ
S
A
Y
V
HSSM
N
A
E
D
---
Y
A
K
V
A
R
Y
F
E
-
K
--
L
----------------
T
--
V
I
D
D
F
Y
A
L
-----
D
D
L
V
C
K
I
T
F
T
AQENES
F
T
I
F
E
H
F
Q
K
Q
SFVKD
K
V
L
V
P
VSSGF-
N
-------
F
I
D
L
ILPDQHK
A
H
G
L
K
L
L
L
Q
K
WQVQPD
Q
V
V
A
IGDNNN
D
I
Q
M
I
K----AAGY
G
F
----
A
V
----
E
A
----
L
K
SVTPYTTA-NNEQE
G
A
L
Q
V
I
D
L
V
L
QHQPPFA
3
PsiBlast_PDB
95.50
38%
-126
- C- -
-
2HF2
-
SUPH_ECOLI
A:
[1-269]
L
S
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
A
-
K
T
Y
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
N
N
Q
Y
Y
Q
L
------------
I
S
F
F
P
E
L
----
K
------
D
E
I
S
F
V
-
A
E
N
G
A
L
V
-
Y
E
-
H
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
-
V
I
G
E
L
L
K
-----
N
F
V
-
A
--
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
---
V
A
L
M
A
K
H
Y
H
-
R
--
L
----------------
K
--
P
V
K
D
Y
Q
E
I
-----
D
D
V
L
F
K
F
S
L
N
L
P
D
E
Q
I
P
L
V
I
D
---
K
L
H
V
A
L
D
G
I
M
K
P
V
T
S
G
F
-
G
-------
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
----
M
A
R
Y
S
F
A
M
GN
A
A
----
E
N
----
I
K
Q
I
A
R
Y
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
S
P
F
-
24
PsiBlast_CBE
95.26
40%
-115
- C1 -
-
1RLM
1
SUPH_ECOLI
D:
[2-269]
-
A
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
A
-
K
T
Y
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
L
------------
I
S
F
F
P
E
L
----
K
------
D
E
I
S
F
V
-
A
E
N
G
A
L
V
-
Y
E
-
H
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
-
V
I
G
E
L
L
K
D
-
K
Q
L
N
F
V
-
A
--
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
---
V
A
L
M
A
K
H
Y
H
-
R
--
L
----------------
K
--
P
V
K
D
Y
Q
E
I
-----
D
D
V
L
F
K
F
S
L
N
L
P
D
E
Q
I
P
L
V
I
D
---
K
L
H
V
A
L
D
G
I
M
K
P
V
T
S
G
F
-
G
-------
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
----
M
A
R
Y
S
F
----
A
M
GNAA
E
N
----
I
K
Q
I
A
R
Y
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
-
21
PsiBlast_CBE
94.77
40%
-114
- C1 -
-
1RLT
2
SUPH_ECOLI
D:
[3-269]
--
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
A
-
K
T
Y
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
L
------------
I
S
F
F
P
E
L
----
K
------
D
E
I
S
F
V
-
A
E
N
G
A
L
V
-
Y
E
-
H
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
-
V
I
G
E
L
L
K
D
-
K
Q
L
N
F
V
-
A
--
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
---
V
A
L
M
A
K
H
Y
H
-
R
--
L
----------------
K
--
P
V
K
D
Y
Q
E
I
-----
D
D
V
L
F
K
F
S
L
N
L
P
D
E
Q
I
P
L
V
I
D
---
K
L
H
V
A
L
D
G
I
M
K
P
V
T
S
G
F
-
G
-------
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
----
M
A
R
Y
S
F
----
A
M
GNAA
E
N
----
I
K
Q
I
A
R
Y
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
-
26
PsiBlast_CBE
93.72
40%
-114
- C1 -
-
1RLM
1
SUPH_ECOLI
B:
[2-269]
-
A
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
A
-
K
T
Y
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
L
------------
I
S
F
F
P
E
L
----
K
------
D
E
I
S
F
V
-
A
E
N
G
A
L
V
-
Y
E
-
H
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
-
V
I
G
E
L
L
K
D
-
K
Q
L
N
F
V
-
A
--
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
---
V
A
L
M
A
K
H
Y
H
-
R
--
L
----------------
K
--
P
V
K
D
Y
Q
E
I
-----
D
D
V
L
F
K
F
S
L
N
L
P
D
E
Q
I
P
L
V
I
D
---
K
L
H
V
A
L
D
G
I
M
K
P
V
T
S
G
F
-
G
-------
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
----
M
A
R
Y
S
F
----
A
M
GNAA
E
N
----
I
K
Q
I
A
R
Y
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
-
25
PsiBlast_CBE
93.43
40%
-109
- C1 -
-
1RLM
2
SUPH_ECOLI
C:
[2-269]
-
A
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
A
-
K
T
Y
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
L
------------
I
S
F
F
P
E
L
----
K
------
D
E
I
S
F
V
-
A
E
N
G
A
L
V
-
Y
E
-
H
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
-
V
I
G
E
L
L
K
D
-
K
Q
L
N
F
V
-
A
--
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
---
V
A
L
M
A
K
H
Y
H
-
R
--
L
----------------
K
--
P
V
K
D
Y
Q
E
I
-----
D
D
V
L
F
K
F
S
L
N
L
P
D
E
Q
I
P
L
V
I
D
---
K
L
H
V
A
L
D
G
I
M
K
P
V
T
S
G
F
-
G
-------
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
----
M
A
R
Y
S
F
----
A
M
GNAA
E
N
----
I
K
Q
I
A
R
Y
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
-
1
PsiBlast_PDB
92.27
40%
-107
- C1 -
-
1RLM
2
SUPH_ECOLI
A:
[2-269]
-
A
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
A
-
K
T
Y
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
L
------------
I
S
F
F
P
E
L
----
K
------
D
E
I
S
F
V
-
A
E
N
G
A
L
V
-
Y
E
-
H
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
-
V
I
G
E
L
L
K
D
-
K
Q
L
N
F
V
-
A
--
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
---
V
A
L
M
A
K
H
Y
H
-
R
--
L
----------------
K
--
P
V
K
D
Y
Q
E
I
-----
D
D
V
L
F
K
F
S
L
N
L
P
D
E
Q
I
P
L
V
I
D
---
K
L
H
V
A
L
D
G
I
M
K
P
V
T
S
G
F
-
G
-------
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
----
M
A
R
Y
S
F
----
A
M
GNAA
E
N
----
I
K
Q
I
A
R
Y
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
-
22
PsiBlast_CBE
92.16
40%
-109
- C1 -
-
1RLT
2
SUPH_ECOLI
C:
[3-269]
--
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
A
-
K
T
Y
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
L
------------
I
S
F
F
P
E
L
----
K
------
D
E
I
S
F
V
-
A
E
N
G
A
L
V
-
Y
E
-
H
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
-
V
I
G
E
L
L
K
D
-
K
Q
L
N
F
V
-
A
--
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
---
V
A
L
M
A
K
H
Y
H
-
R
--
L
----------------
K
--
P
V
K
D
Y
Q
E
I
-----
D
D
V
L
F
K
F
S
L
N
L
P
D
E
Q
I
P
L
V
I
D
---
K
L
H
V
A
L
D
G
I
M
K
P
V
T
S
G
F
-
G
-------
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
----
M
A
R
Y
S
F
----
A
M
GNAA
E
N
----
I
K
Q
I
A
R
Y
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
-
2
PsiBlast_PDB
91.96
40%
-106
- C1 -
-
1RLT
1
SUPH_ECOLI
A:
[3-269]
--
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
A
-
K
T
Y
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
L
------------
I
S
F
F
P
E
L
----
K
------
D
E
I
S
F
V
-
A
E
N
G
A
L
V
-
Y
E
-
H
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
-
V
I
G
E
L
L
K
D
-
K
Q
L
N
F
V
-
A
--
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
---
V
A
L
M
A
K
H
Y
H
-
R
--
L
----------------
K
--
P
V
K
D
Y
Q
E
I
-----
D
D
V
L
F
K
F
S
L
N
L
P
D
E
Q
I
P
L
V
I
D
---
K
L
H
V
A
L
D
G
I
M
K
P
V
T
S
G
F
-
G
-------
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
----
M
A
R
Y
S
F
----
A
M
GNAA
E
N
----
I
K
Q
I
A
R
Y
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
-
23
PsiBlast_CBE
90.20
40%
-109
- C1 -
-
1RLT
1
SUPH_ECOLI
B:
[3-269]
--
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
A
-
K
T
Y
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
L
------------
I
S
F
F
P
E
L
----
K
------
D
E
I
S
F
V
-
A
E
N
G
A
L
V
-
Y
E
-
H
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
-
V
I
G
E
L
L
K
D
-
K
Q
L
N
F
V
-
A
--
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
---
V
A
L
M
A
K
H
Y
H
-
R
--
L
----------------
K
--
P
V
K
D
Y
Q
E
I
-----
D
D
V
L
F
K
F
S
L
N
L
P
D
E
Q
I
P
L
V
I
D
---
K
L
H
V
A
L
D
G
I
M
K
P
V
T
S
G
F
-
G
-------
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
----
M
A
R
Y
S
F
----
A
M
GNAA
E
N
----
I
K
Q
I
A
R
Y
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
-
45
HHSearch
87.07
41%
-50
- C1 -
-
1RLM
1
SUPH_ECOLI
D:
[2-269]
-
A
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
A
-
K
T
Y
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
L
------------
I
S
F
F
P
E
L
----
K
------
D
E
I
S
F
V
-
A
E
N
G
A
L
V
-
Y
E
-
H
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
V
I
G
E
L
L
K
D
K
--
Q
L
N
F
V
-
A
--
C
G
L
Q
S
A
Y
V
S
E
N
A
P
E
A
F
---
V
A
L
M
A
K
H
Y
H
-
R
--
L
----------------
K
--
P
V
K
D
Y
Q
E
I
-----
D
D
V
L
F
K
F
S
L
N
L
P
D
E
Q
I
P
L
V
I
D
K
L
H
V
A
---
L
D
G
I
M
K
P
V
T
S
G
F
-
G
-------
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
----
M
A
R
Y
S
F
----
A
M
----
G
N
AAEN
I
K
Q
I
A
R
Y
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
N
T
Y
P
F
-
50
HHSearch
75.93
33%
-42
- C1 -
-
3L7Y
-
?
A:
[36-302]
-
S
V
K
V
I
A
T
D
M
D
G
T
F
L
N
S
K
-
G
S
Y
D
H
N
R
F
Q
R
I
L
K
Q
L
Q
E
R
D
I
R
F
V
V
A
S
S
N
P
Y
R
Q
L
------------
R
E
H
F
P
D
C
----
H
------
E
Q
L
T
F
V
-
G
E
N
G
A
N
I
-
I
S
-
K
N
Q
S
L
I
E
V
F
Q
Q
R
E
D
I
A
S
-
I
I
Y
F
I
E
E
K
Y
P
Q
A
V
I
A
-
L
--
S
G
E
K
K
G
Y
L
K
K
G
V
S
E
N
I
---
V
K
M
L
S
P
F
F
P
-
V
--
L
----------------
E
--
L
V
N
S
F
S
P
L
-----
P
E
R
F
F
K
L
T
L
Q
V
K
E
E
E
S
A
Q
I
M
K
A
I
A
D
Y
--
K
T
S
Q
R
L
V
G
T
A
S
G
F
-
G
-------
Y
I
D
I
I
T
K
G
L
H
K
G
W
A
L
Q
Q
L
L
K
R
W
N
F
T
S
D
H
L
M
A
F
G
D
G
G
N
D
I
E
M
L
K
----
L
A
K
Y
S
Y
----
A
M
----
A
N
AP
K
N
V
K
A
A
A
N
Y
Q
A
K
-
S
N
D
E
S
G
V
L
D
V
I
D
N
Y
L
A
S
-----
4
PsiBlast_PDB
72.32
33%
-14
- C1 -
-
3L7Y
-
?
A:
[36-297]
-
S
V
K
V
I
A
T
D
M
D
G
T
F
L
N
S
K
-
G
S
Y
D
H
N
R
F
Q
R
I
L
K
Q
L
Q
E
R
D
I
R
F
V
V
A
S
S
N
P
Y
R
Q
L
------------
R
E
H
F
P
D
C
----
H
------
E
Q
L
T
F
V
-
G
E
N
G
A
N
I
-
I
S
-
K
N
Q
S
L
I
E
V
F
Q
Q
R
E
D
I
A
S
-
I
I
Y
F
I
E
E
K
-
Y
P
Q
A
V
I
A
L
--
S
G
E
K
K
G
Y
L
K
K
G
V
S
E
N
I
---
V
K
M
L
S
P
F
F
P
-
V
--
L
----------------
E
--
L
V
N
S
F
S
P
L
P-----
E
R
F
F
K
L
T
L
Q
V
K
E
E
E
S
A
Q
I
M
K
A
I
--
A
D
Y
K
T
S
Q
R
L
V
G
T
A
S
G
F
-
G
-------
Y
I
D
I
I
T
K
G
L
H
K
G
W
A
L
Q
Q
L
L
K
R
W
N
F
T
S
D
H
L
M
A
F
G
D
G
G
N
D
I
E
M
L
K
----
L
A
K
Y
S
Y
----
A
M
ANAP
K
N
----
V
K
A
A
A
N
Y
Q
A
K
-
S
N
D
E
S
G
V
L
D
V
I
D
----------
46
HHSearch
59.31
20%
-64
- C1 -
-
3DAO
1
?
B:
[20-283]
-
M
I
K
L
I
A
T
D
I
D
G
T
L
V
K
D
G
-
S
L
L
I
D
P
E
Y
M
S
V
I
D
R
L
I
D
K
G
I
I
F
V
V
C
S
G
R
Q
F
S
S
E
------------
F
K
L
F
A
P
I
----
K
------
H
K
L
L
Y
I
-
T
D
G
G
T
V
V
-
R
T
-
P
K
E
I
L
K
T
Y
P
M
D
E
D
I
W
K
G
-
M
C
R
M
V
R
D
E
L
P
A
C
D
Y
F
-
A
--
A
T
P
D
F
C
F
A
E
D
G
G
S
-
P
I
---
F
H
L
L
R
D
S
Y
G
F
E
--
M
----------------
R
--
E
V
D
D
I
T
R
L
D----
R
N
D
I
I
K
F
T
V
F
H
P
D
K
-
C
E
E
L
C
T
P
V
F
I
P
--
A
W
N
K
K
A
H
L
A
A
A
G
K
-
E
-------
W
V
D
C
N
A
K
G
V
S
K
W
T
A
L
S
Y
L
I
D
R
F
D
L
L
P
D
E
V
C
C
F
G
D
N
L
N
D
I
E
M
L
Q
----
N
A
G
I
S
Y
----
A
V
----
S
N
AR
Q
E
V
I
A
A
A
K
H
T
C
A
-
P
Y
W
E
N
G
V
L
S
V
L
K
S
F
L
-------
48
HHSearch
59.08
19%
-32
- C1 -
-
4ZEV
-
?
B:
[27-295]
D
E
I
K
I
I
F
T
A
L
D
G
T
L
L
N
S
E
-
N
K
V
S
-
E
Q
N
L
E
S
L
I
R
A
Q
E
K
G
I
K
V
V
I
A
T
G
R
S
I
F
S
V
------------
E
N
V
I
G
E
H
V
K
K
N
R
I-----
S
L
L
P
G
I
-
Y
M
N
G
C
V
T
F
D
E
-
K
G
S
R
V
I
D
R
I
M
N
N
D
L
K
M
E
-
I
H
E
F
S
K
Q
I
N
I
S
K
Y
A
I
-
W
--
F
C
L
E
K
T
Y
C
F
E
I
N
D
--------
C
I
R
E
Y
M
E
-
V
EA
L
N
P
--------------
D
--
V
I
E
D
N
M
L
E
-----
G
L
T
V
Y
K
V
L
F
S
L
P
E
N
I
L
E
N
T
L
K
L
C
R
E
K
---
F
S
H
R
I
N
V
A
N
T
F
Q
-
S
-------
Y
V
E
L
F
H
Q
H
T
N
K
F
E
G
V
K
E
I
C
K
Y
Y
N
I
S
L
N
N
A
L
A
M
G
D
G
E
N
D
I
E
M
L
S
----
G
L
T
H
S
V
----
G
V
----
H
N
AS
E
K
V
K
N
S
A
A
Y
V
G
P
-
S
N
N
E
H
A
I
S
H
V
L
K
T
F
C
D
------
49
HHSearch
57.54
19%
-25
- C1 -
-
4ZEX
1
?
A:
[27-295]
D
E
I
K
I
I
F
T
A
L
D
G
T
L
L
N
S
E
-
N
K
V
S
-
E
Q
N
L
E
S
L
I
R
A
Q
E
K
G
I
K
V
V
I
A
T
G
R
S
I
F
S
V
------------
E
N
V
I
G
E
H
V
K
K
N
R
I-----
S
L
L
P
G
I
-
Y
M
N
G
C
V
T
F
D
E
-
K
G
S
R
V
I
D
R
I
M
N
N
D
L
K
M
E
-
I
H
E
F
S
K
Q
I
N
I
S
K
Y
A
I
-
W
--
F
C
L
E
K
T
Y
C
F
E
I
N
D
--------
C
I
R
E
Y
M
E
-
V
E
A
L
N
P
--------------
D
--
V
I
E
D
N
M
L
E
-----
G
L
T
V
Y
K
V
L
F
S
L
P
E
N
I
L
E
N
T
L
K
L
C
R
E
K
---
F
S
H
R
I
N
V
A
N
T
F
Q
-
S
-------
Y
V
E
L
F
H
Q
H
T
N
K
F
E
G
V
K
E
I
C
K
Y
Y
N
I
S
L
N
N
A
L
A
M
G
D
G
E
N
D
I
E
M
L
S
----
G
L
T
H
S
V
----
G
V
----
H
N
AS
E
K
V
K
N
S
A
A
Y
V
G
P
-
S
N
N
E
H
A
I
S
H
V
L
K
T
F
C
D
------
5
PsiBlast_PDB
57.18
23%
-15
- C1 -
-
4DW8
3
?
A:
[6-268]
---
K
L
I
V
L
D
L
D
G
T
L
T
N
S
K
-
K
E
I
S
-
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
------------
V
P
L
A
N
E
L
RM--
N
------
E
F
G
G
F
I
L
S
Y
N
G
G
E
I
-
I
N
W
E
S
K
E
M
M
Y
E
N
V
L
P
N
E
V
V
P
-
V
L
--
Y
E
C
A
-
R
T
N
H
L
S
-
I
--
L
T
Y
D
G
A
E
I
V
T
E
N
S
L
D
P
---
Y
V
Q
K
E
A
F
L
N
-
K
--
M
----------------
A
--
I
R
E
T
---------
N
D
F
L
T
D
I
T
L
P
V
A
K
---
C
L
I
V
G
D
A
G
K
L
I
P
V
E
S
E
L
C
I
R
L
Q
G
K
I
-
N
V
F
R
SEPY
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
----
F
A
G
M
G
V
----
A
M
GNAQ
E
P
----
V
K
K
A
A
D
Y
I
T
L
-
T
N
D
E
D
G
V
A
E
A
I
E
R
I
--------
56
HHSearch
56.94
22%
-22
- C1 -
-
1NRW
-
YWPJ_BACSU
A:
[4-288]
--
M
K
L
I
A
I
D
L
D
G
T
L
L
N
S
K
-
H
Q
V
S
-
L
E
N
E
N
A
L
R
Q
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
V
------------
M
S
I
F
E
P
L
----
G
------
I
K
T
W
V
I
-
S
A
N
G
A
V
I
H
D
P
-
E
G
R
L
Y
H
H
E
T
I
D
K
K
R
A
Y
D
-
I
L
S
W
L
E
S
E
--
N
Y
Y
Y
E
-
V
--
F
T
G
S
A
I
Y
T
P
Q
N
G
R
E
L
L
D
V
E
L
D
R
F
R
S
A
N
P
-
E
AD
L
S
V
L
K
Q
A
A
E
V
Q
Y
S
Q
SG
F
A
--
Y
I
N
S
F
Q
E
L
FEAD
E
P
I
D
F
Y
N
I
L
G
F
S
F
F
--
K
E
K
L
E
A
G
W
K
R
Y
--
E
H
A
E
D
L
T
L
V
S
S
A
E
-
H
-------
N
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
----
A
A
G
K
G
V
----
A
M
----
G
N
AR
E
D
I
K
S
I
A
D
A
V
T
L
-
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
-------
6
PsiBlast_PDB
56.80
23%
-13
- C1 -
-
3NIW
1
?
A:
[6-268]
---
K
L
I
V
L
D
L
D
G
T
L
T
N
S
K
-
K
E
I
S
-
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
------------
V
P
L
A
N
E
L
RM--
N
------
E
F
G
G
F
I
L
S
Y
N
G
G
E
I
-
I
N
W
E
S
K
E
M
M
Y
E
N
V
L
P
N
E
V
V
P
-
V
L
--
Y
E
C
A
-
R
T
N
H
L
S
-
I
--
L
T
Y
D
G
A
E
I
V
T
E
N
S
L
D
P
---
Y
V
Q
K
E
A
F
L
N
-
K
--
M
----------------
A
--
I
R
E
T
---------
N
D
F
L
T
D
I
T
L
P
V
A
K
---
C
L
I
V
G
D
A
G
K
L
I
P
V
E
S
E
L
C
I
R
L
Q
G
K
I
-
N
V
F
R
SEPY
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
----
F
A
G
M
G
V
----
A
M
GNAQ
E
P
----
V
K
K
A
A
D
Y
I
T
L
-
T
N
D
E
D
G
V
A
E
A
I
E
R
I
--------
47
HHSearch
56.23
18%
-26
- C1 -
-
2B30
-
?
D:
[25-300]
A
D
I
K
L
L
L
I
D
F
D
G
T
L
F
V
D
K
D
I
K
V
P
-
S
E
N
I
D
A
I
K
E
A
I
E
K
G
Y
M
V
S
I
C
T
G
R
S
K
V
G
I
------------
L
S
A
F
G
E
E
----
N
LKKMNF
Y
G
M
P
G
V
-
Y
I
N
G
T
I
V
Y
D
Q
-
I
G
Y
T
L
L
D
E
T
I
E
T
D
V
Y
A
E
-
L
I
S
Y
L
V
E
K
N
L
V
N
Q
T
I
-
F
--
H
R
G
E
S
N
Y
V
T
E
D
N
K
Y
-----
A
D
F
L
Q
K
M
Y
S
-
E
NR
S
----------------
I
--
I
I
R
-
H
N
E
M
LK---
Y
R
T
M
N
K
L
M
I
V
L
D
P
S
E
S
K
T
V
I
G
N
L
K
Q
K
---
F
K
N
K
L
T
I
F
T
T
Y
N
-
G
-------
H
A
E
V
T
K
L
G
H
D
K
Y
T
G
I
N
Y
L
L
K
H
Y
N
I
S
N
D
Q
V
L
V
V
G
D
A
E
N
D
I
A
M
L
S
----
N
F
K
Y
S
F
----
A
V
----
A
N
ATDS
A
K
S
H
A
K
C
V
L
P
V
S
H
R
E
G
A
V
A
Y
L
L
K
K
V
F
D
L
K
----
15
PsiBlast_PDB
54.78
22%
3
- C1 -
-
4ZEV
1
?
A:
[29-290]
--
I
K
I
I
F
T
A
L
D
G
T
L
L
N
S
E
-
N
K
V
S
E
Q
N
-
L
E
S
L
I
R
A
Q
E
K
G
I
K
V
V
I
A
T
G
R
S
I
F
S
V
E
N
V
I
G
E
H
V
K
K
NR
I
S
L
L
P
G
I
YM--
N
------
G
C
V
T
F
--
D
E
K
G
S
R
V
-
I
D
-
R
-------
I
M
N
N
D
L
K
M
E
-
I
H
E
F
S
K
Q
I
-
N
I
S
K
Y
A
-
I
W
F
C
L
E
K
T
Y
C
F
E
I
N
D
C
I
R
E
---
Y
M
E
V
----
E
-
A
--
L
----------------
N
P
D
V
I
E
D
N
M
L
E
-----
G
L
T
V
Y
K
V
L
F
S
L
P
E
N
----
I
L
E
N
T
L
K
L
C
R
E
K
F
S
H
R
I
N
V
A
N
T
F
Q
S
-------
Y
V
E
L
F
H
Q
H
T
N
K
F
E
G
V
K
E
I
C
K
Y
Y
N
I
S
L
N
N
A
L
A
M
G
D
G
E
N
D
I
E
M
L
S
G
L
T
H
S
V
G
V
H
N
----
A
S
----
E
K
----
V
K
N
S
A
A
Y
V
G
P
-
S
N
N
E
H
A
I
S
H
V
L
-----------