@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUY4: (2017-12-21 )
MSVVAFKQVDVFTSQAFKGNPVAVIMDASTLTSEQMQAIANWTNLSETTFVLPAIDSQADYQVRIFTPQSELPFAGHPTIGTAYALLEAGLVKAKEGQLVQQCAAGLVTLTVNDSNHISFELPKPKITPLDALQTQKLAEILKCKINTQWNAALVDVGARWVVLQAVNAKAVLASQPDLNALKQFSLEMKVTGSTIYGFYEESNEQKRIEVRSFAPAYGVNEDPVCGSGNGSVASFIRYHSILPAQNDVMLSSQGQALGREGQLQLELHQDKILVGGAAVTCIDGTIKL
Atome Classification :
(20 SA)
.........10........20....----.----...30........40........50........60........70........80........90........100.......110---.....----..120-..---..--..-.130.......140...--...-.150.------........160.......170.......180.......190.......200-.......210.......220.......230.......240...--....250-........260------........-----.270---.-----........280.......-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
V
V
A
F
K
Q
V
D
V
F
TSQAFKGN
P
V
A
V
I
----
M
----DASTL
T
S
E
Q
M
Q
A
I
A
NWTNLSE
T
T
F
V
L
PAIDSQA
D
Y
Q
V
R
I
F
TPQSELPFAGHPT
I
G
T
A
Y
A
L
L
E
A
G
LVKAKE
G
Q
L
V
Q
Q
CAA
G
L
V
T
L
T
V---NDSN
H
----
I
S
F
EL-PK---PK--IT-
P
L
D
A
L
Q
T
Q
K
L
A
E
I
L
K
C
K--INT-QW--
N
------
A
A
L
VDVGA
R
W
V
V
L
Q
AVN
A
K
A
V
LASQP
D
L
N
A
L
K
QF
S
L
E
M
K
V
TG
S
T
I
Y
G
F
YEE-SNE
Q
K
R
I
E
V
RSFAPAYGVNEDPVCGSGN
G
S
V
A
S
F
I
R
Y
H
SILPA--QN
D
V
M
L--SSQGQALGR--------EG
Q
L
Q
L
E
L-----HQ-----
D
-----
K
I
L
VG
G
A
A
V
T
C
IDGTIKL-
25
HHSearch
74.88
33%
-60
- C2 -
-
1T6K
-
PHZF_PSEFL
A:
[1-278]
--
M
H
N
Y
V
I
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
----
F
----
D
A
D
D
L
P
P
A
Q
M
Q
R
I
A
R
E
M
N
L
S
E
S
T
F
V
L
K
P
R
-
N
G
G
D
A
L
I
R
I
F
T
P
V
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
G
A
H
T
D
N
----
H
R
L
Y
L
E
T
Q
M
G
T
I
A
F
E
L
---
E
R
Q
N
G
----
S
V
I
A
A
S
M
D
Q
--
P
I
P
T
W
T
-
A
L
G
--
R
D
A
E
L
L
K
A
L
G
I
S
--
D
-
S
-
T
F
--
P
------
I
E
I
Y
H
N
G
P
R
H
V
F
V
G
L
P
S
I
D
A
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
D
----
M
A
I
N
C
F
A
G
A
-----
G
-
R
R
W
R
S
R
M
F
S
P
A
Y
G
V
V
E
D
A
A
T
G
S
A
A
G
P
L
A
I
H
L
A
R
H
G
Q
I
E
---
F
G
Q
P
V
E
--
I
L
Q
G
V
E
I
G
R
--------
P
S
L
M
F
A
K
A
-----
E
G
-----
R
AEQLT
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
-
42
Fugue
73.68
37%
-2
- C2 -
-
1YM5
-
YHI9_YEAST
A:
[2-295]
T
L
M
V
P
F
K
Q
V
D
V
F
T
E
K
P
F
M
G
N
P
V
A
V
I
----
N
FLEI
D
E
N
E
V
S
Q
E
E
L
Q
A
I
A
N
W
T
N
L
S
E
T
T
F
L
F
K
P
S
D
K
K
Y
D
Y
K
L
R
I
F
T
P
R
S
E
L
P
F
A
G
H
P
T
I
G
S
C
K
A
F
L
E
F
T
K
N
T
-
T
A
T
S
L
V
Q
E
C
K
I
G
A
V
P
I
T
I
---
N
E
-
G
L
----
I
S
F
K
A
-
P
M
---
A
D
--
Y
E
-
S
I
S
S
E
M
I
A
D
Y
E
K
A
I
G
----
L
K
F
-
I
K
--
P
------
P
A
L
L
H
T
G
P
E
W
I
V
A
L
V
E
D
A
E
T
C
F
N
A
N
P
N
F
A
M
L
A
H
Q
T
K
Q
N
D
H
V
G
I
I
L
A
G
P
K
K
E
-
A
A
I
K
N
S
Y
E
M
R
A
F
A
P
V
I
N
V
Y
E
D
P
V
C
G
S
G
S
V
A
L
A
R
Y
L
Q
E
V
Y
-
K
F
E
--
K
T
T
D
I
T
--
I
S
E
G
G
R
L
K
R
--------
N
G
L
M
L
A
S
I
-----
K
K
-----
E
ADN
S
T
S
Y
Y
I
A
G
H
A
T
T
V
I
D
G
K
I
K
V
H
21
HHSearch
73.24
32%
-60
- C2 -
-
1XUB
-
PHZF_PSEFL
A:
[21-298]
--
M
H
N
Y
V
I
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
----
F
----
D
A
D
D
L
P
P
A
Q
M
Q
R
I
A
R
E
M
N
L
S
E
S
T
F
V
L
K
P
R
-
N
G
G
D
A
L
I
R
I
F
T
P
V
N
E
L
P
F
A
G
A
P
L
L
G
T
A
I
A
L
G
A
H
T
D
N
----
H
R
L
Y
L
E
T
Q
M
G
T
I
A
F
E
L
---
E
R
Q
N
G
----
S
V
I
A
A
S
M
D
Q--
P
I
P
T
W
T
-
A
L
G
--
R
D
A
E
L
L
K
A
L
G
I
S
--
D
-
S
-
T
F
--
P
------
I
E
I
Y
H
N
G
P
R
H
V
F
V
G
L
P
S
I
D
A
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
D
----
M
A
I
N
C
F
A
G
A
-----
G
-
R
R
W
R
S
R
M
F
S
P
A
Y
G
V
V
E
D
A
A
T
G
S
A
A
G
P
L
A
I
H
L
A
R
H
G
Q
I
E
---
F
G
Q
P
V
E
--
I
L
Q
G
V
E
I
G
R
--------
P
S
L
M
F
A
K
A
-----
E
G
RAEQL
T
-----
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
-
1
PsiBlast_PDB
73.19
37%
11
- C2 -
-
1YM5
-
YHI9_YEAST
A:
[4-294]
--
M
V
P
F
K
Q
V
D
V
F
T
E
K
P
F
M
G
N
P
V
A
V
I
N
FLE
I
----
D
E
N
E
V
S
Q
E
E
L
Q
A
I
A
N
W
T
N
L
S
E
T
T
F
L
F
K
P
S
D
K
K
Y
D
Y
K
L
R
I
F
T
P
R
S
E
L
P
F
A
G
H
P
T
I
G
S
C
K
A
F
L
E
F
-
T
K
N
T
T
A
T
S
L
V
Q
E
C
K
I
G
A
V
P
I
T
I
---
N
E
G
-
L
----
I
S
F
K
A
-
P
--------
M
A
-
D
Y
E
S
I
S
S
E
M
I
A
D
Y
E
K
A
---
I
G
L
-
K
F
I
K
P
------
P
A
L
L
H
T
G
P
E
W
I
V
A
L
V
E
D
A
E
T
C
F
N
A
N
P
N
F
A
M
L
A
H
Q
T
K
Q
N
D
H
V
G
I
I
L
A
G
P
K
K
E
-
A
A
I
K
N
S
Y
E
M
R
A
F
A
P
V
I
N
V
Y
E
D
P
V
C
G
S
G
S
V
A
L
A
R
Y
L
Q
E
V
Y
K
F
E
K
--
T
T
D
I
T
I
--
S
E
G
G
R
-
L
K
R
--------
N
G
L
M
L
A
S
I
-----
K
K
-----
E
ADN
S
T
S
Y
Y
I
A
G
H
A
T
T
V
I
D
G
K
I
K
V
-
4
PsiBlast_PDB
72.00
33%
-46
- C2 -
-
1T6K
-
PHZF_PSEFL
A:
[7-278]
--------
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
----
F
----
D
A
D
D
L
P
P
A
Q
M
Q
R
I
A
R
E
M
N
L
S
E
S
T
F
V
L
K
P
R
N
G
-
G
D
A
L
I
R
I
F
T
P
V
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
----
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
M
G
T
I
A
F
E
L
---
E
R
Q
N
G
SVI
A
A
S
M
D
Q
-
P
I
---
P
T
--
W
T
-
A
L
G
-----
R
D
A
E
L
L
K
A
L
GI
S
D
S
-
T
F
--
P
------
I
E
I
Y
H
N
G
P
R
H
V
F
V
G
L
P
S
I
D
A
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
-
D
M
A
I
N
C
F
A
G
A
G
---------
R
R
W
R
S
R
M
F
S
P
A
Y
G
V
V
E
D
A
A
T
G
S
A
A
G
P
L
A
I
H
L
A
R
H
G
Q
I
E
F
--
G
Q
P
V
E
I
---
L
Q
G
V
E
I
G
R
P
S
L
M
F
A
K
A
E
G
R
A
E
--------
Q
L
-----
T
-----
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
-
19
PsiBlast_CBE
71.41
33%
-45
- C2 -
-
1U1W
2
PHZF_PSEFL
B:
[27-298]
--------
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
----
F
----
D
A
D
D
L
P
P
A
Q
M
Q
R
I
A
R
E
M
N
L
S
E
S
T
F
V
L
K
P
R
N
G
-
G
D
A
L
I
R
I
F
T
P
V
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
----
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
M
G
T
I
A
F
E
L
---
E
R
Q
N
G
SVI
A
A
S
M
D
Q
-
P
I
---
P
T
--
W
T
-
A
L
G
-----
R
D
A
E
L
L
K
A
L
GI
S
D
S
-
T
F
--
P
------
I
E
I
Y
H
N
G
P
R
H
V
F
V
G
L
P
S
I
D
A
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
-
D
M
A
I
N
C
F
A
G
A
G
---------
R
R
W
R
S
R
M
F
S
P
A
Y
G
V
V
E
D
A
A
T
G
S
A
A
G
P
L
A
I
H
L
A
R
H
G
Q
I
E
F
--
G
Q
P
V
E
I
---
L
Q
G
V
E
I
G
R
P
S
L
M
F
A
K
A
E
G
R
A
E
--------
Q
L
-----
T
-----
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
-
6
PsiBlast_PDB
70.95
33%
-44
- C2 -
-
1U1X
1
PHZF_PSEFL
A:
[27-298]
--------
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
----
F
----
D
A
D
D
L
P
P
A
Q
M
Q
R
I
A
R
E
M
N
L
S
E
S
T
F
V
L
K
P
R
N
G
-
G
D
A
L
I
R
I
F
T
P
V
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
----
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
M
G
T
I
A
F
E
L
---
E
R
Q
N
G
SVI
A
A
S
M
D
Q
-
P
I
---
P
T
--
W
T
-
A
L
G
-----
R
D
A
E
L
L
K
A
L
GI
S
D
S
-
T
F
--
P
------
I
E
I
Y
H
N
G
P
R
H
V
F
V
G
L
P
S
I
D
A
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
-
D
M
A
I
N
C
F
A
G
A
G
---------
R
R
W
R
S
R
M
F
S
P
A
Y
G
V
V
E
D
A
A
T
G
S
A
A
G
P
L
A
I
H
L
A
R
H
G
Q
I
E
F
--
G
Q
P
V
E
I
---
L
Q
G
V
E
I
G
R
P
S
L
M
F
A
K
A
E
G
R
A
E
--------
Q
L
-----
T
-----
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
-
7
PsiBlast_PDB
70.83
33%
-46
- C2 -
-
1XUA
1
PHZF_PSEFL
A:
[27-298]
--------
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
----
F
----
D
A
D
D
L
P
P
A
Q
M
Q
R
I
A
R
E
M
N
L
S
E
S
T
F
V
L
K
P
R
N
G
-
G
D
A
L
I
R
I
F
T
P
V
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
----
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
M
G
T
I
A
F
E
L
---
E
R
Q
N
G
SVI
A
A
S
M
D
Q
-
P
I
---
P
T
--
W
T
-
A
L
G
-----
R
D
A
E
L
L
K
A
L
GI
S
D
S
-
T
F
--
P
------
I
E
I
Y
H
N
G
P
R
H
V
F
V
G
L
P
S
I
D
A
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
-
D
M
A
I
N
C
F
A
G
A
G
---------
R
R
W
R
S
R
M
F
S
P
A
Y
G
V
V
E
D
A
A
T
G
S
A
A
G
P
L
A
I
H
L
A
R
H
G
Q
I
E
F
--
G
Q
P
V
E
I
---
L
Q
G
V
E
I
G
R
P
S
L
M
F
A
K
A
E
G
R
A
E
--------
Q
L
-----
T
-----
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
-
17
PsiBlast_CBE
70.66
33%
-44
- C2 -
-
1XUA
1
PHZF_PSEFL
B:
[27-298]
--------
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
----
F
----
D
A
D
D
L
P
P
A
Q
M
Q
R
I
A
R
E
M
N
L
S
E
S
T
F
V
L
K
P
R
N
G
-
G
D
A
L
I
R
I
F
T
P
V
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
----
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
M
G
T
I
A
F
E
L
---
E
R
Q
N
G
SVI
A
A
S
M
D
Q
-
P
I
---
P
T
--
W
T
-
A
L
G
-----
R
D
A
E
L
L
K
A
L
GI
S
D
S
-
T
F
--
P
------
I
E
I
Y
H
N
G
P
R
H
V
F
V
G
L
P
S
I
D
A
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
-
D
M
A
I
N
C
F
A
G
A
G
---------
R
R
W
R
S
R
M
F
S
P
A
Y
G
V
V
E
D
A
A
T
G
S
A
A
G
P
L
A
I
H
L
A
R
H
G
Q
I
E
F
--
G
Q
P
V
E
I
---
L
Q
G
V
E
I
G
R
P
S
L
M
F
A
K
A
E
G
R
A
E
--------
Q
L
-----
T
-----
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
-
18
PsiBlast_CBE
70.61
33%
-44
- C2 -
-
1U1X
1
PHZF_PSEFL
B:
[27-298]
--------
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
----
F
----
D
A
D
D
L
P
P
A
Q
M
Q
R
I
A
R
E
M
N
L
S
E
S
T
F
V
L
K
P
R
N
G
-
G
D
A
L
I
R
I
F
T
P
V
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
----
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
M
G
T
I
A
F
E
L
---
E
R
Q
N
G
SVI
A
A
S
M
D
Q
-
P
I
---
P
T
--
W
T
-
A
L
G
-----
R
D
A
E
L
L
K
A
L
GI
S
D
S
-
T
F
--
P
------
I
E
I
Y
H
N
G
P
R
H
V
F
V
G
L
P
S
I
D
A
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
-
D
M
A
I
N
C
F
A
G
A
G
---------
R
R
W
R
S
R
M
F
S
P
A
Y
G
V
V
E
D
A
A
T
G
S
A
A
G
P
L
A
I
H
L
A
R
H
G
Q
I
E
F
--
G
Q
P
V
E
I
---
L
Q
G
V
E
I
G
R
P
S
L
M
F
A
K
A
E
G
R
A
E
--------
Q
L
-----
T
-----
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
-
5
PsiBlast_PDB
70.48
33%
-43
- C2 -
-
1U1W
2
PHZF_PSEFL
A:
[27-298]
--------
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
----
F
----
D
A
D
D
L
P
P
A
Q
M
Q
R
I
A
R
E
M
N
L
S
E
S
T
F
V
L
K
P
R
N
G
-
G
D
A
L
I
R
I
F
T
P
V
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
----
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
M
G
T
I
A
F
E
L
---
E
R
Q
N
G
SVI
A
A
S
M
D
Q
-
P
I
---
P
T
--
W
T
-
A
L
G
-----
R
D
A
E
L
L
K
A
L
GI
S
D
S
-
T
F
--
P
------
I
E
I
Y
H
N
G
P
R
H
V
F
V
G
L
P
S
I
D
A
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
-
D
M
A
I
N
C
F
A
G
A
G
---------
R
R
W
R
S
R
M
F
S
P
A
Y
G
V
V
E
D
A
A
T
G
S
A
A
G
P
L
A
I
H
L
A
R
H
G
Q
I
E
F
--
G
Q
P
V
E
I
---
L
Q
G
V
E
I
G
R
P
S
L
M
F
A
K
A
E
G
R
A
E
--------
Q
L
-----
T
-----
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
-
9
PsiBlast_PDB
70.40
32%
-41
- C2 -
-
1U1V
1
PHZF_PSEFL
A:
[27-298]
--------
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
----
F
----
D
A
D
D
L
P
P
A
Q
M
Q
R
I
A
R
E
M
N
L
S
E
S
T
F
V
L
K
P
R
N
G
-
G
D
A
L
I
R
I
F
T
P
V
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
----
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
M
G
T
I
A
F
E
L
---
E
R
Q
N
G
SVI
A
A
S
M
D
Q
-
P
I
---
P
T
--
W
T
-
A
L
G
-----
R
D
A
E
L
L
K
A
L
GI
S
D
S
-
T
F
--
P
------
I
E
I
Y
H
N
G
P
R
H
V
F
V
G
L
P
S
I
D
A
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
------
D
M
A
I
N
C
F
----
A
G
A
G
R
R
W
R
S
R
M
F
S
P
A
Y
G
V
V
E
D
A
A
T
G
S
A
A
G
P
L
A
I
H
L
A
R
H
G
Q
I
E
F
--
G
Q
P
V
E
I
---
L
Q
G
V
E
I
G
R
P
S
L
M
F
A
K
A
E
G
R
A
E
--------
Q
L
-----
T
-----
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
-
10
PsiBlast_PDB
70.02
32%
-43
- C2 -
-
1XUB
-
PHZF_PSEFL
A:
[27-298]
--------
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
----
F
----
D
A
D
D
L
P
P
A
Q
M
Q
R
I
A
R
E
M
N
L
S
E
S
T
F
V
L
K
P
R
N
G
-
G
D
A
L
I
R
I
F
T
P
V
N
E
L
P
F
A
G
A
P
L
L
G
T
A
I
A
L
----
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
M
G
T
I
A
F
E
L
---
E
R
Q
N
G
SVI
A
A
S
M
D
Q
-
P
I
---
P
T
--
W
T
-
A
L
G
-----
R
D
A
E
L
L
K
A
L
GI
S
D
S
-
T
F
--
P
------
I
E
I
Y
H
N
G
P
R
H
V
F
V
G
L
P
S
I
D
A
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
-
D
M
A
I
N
C
F
A
G
A
G
---------
R
R
W
R
S
R
M
F
S
P
A
Y
G
V
V
E
D
A
A
T
G
S
A
A
G
P
L
A
I
H
L
A
R
H
G
Q
I
E
F
--
G
Q
P
V
E
I
---
L
Q
G
V
E
I
G
R
P
S
L
M
F
A
K
A
E
G
R
A
E
--------
Q
L
-----
T
-----
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
-
8
PsiBlast_PDB
69.80
32%
-45
- C2 -
-
5IWE
7
PHZF_PSEFL
A:
[27-298]
--------
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
----
F
----
D
A
D
D
L
P
P
A
Q
M
Q
R
I
A
R
E
M
N
L
S
Q
S
T
F
V
L
K
P
R
N
G
-
G
D
A
L
I
R
I
F
T
P
V
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
----
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
M
G
T
I
A
F
E
L
---
E
R
Q
N
G
SVI
A
A
S
M
D
Q
-
P
I
---
P
T
--
W
T
-
A
L
G
-----
R
D
A
E
L
L
K
A
L
GI
S
D
S
-
T
F
--
P
------
I
E
I
Y
H
N
G
P
R
H
V
F
V
G
L
P
S
I
D
A
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
-
D
M
A
I
N
C
F
A
G
A
G
---------
R
R
W
R
S
R
M
F
S
P
A
Y
G
V
V
E
D
A
A
T
G
S
A
A
G
P
L
A
I
H
L
A
R
H
G
Q
I
E
F
--
G
Q
P
V
E
I
---
L
Q
G
V
E
I
G
R
P
S
L
M
F
A
K
A
E
G
R
A
E
--------
Q
L
-----
T
-----
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
-
24
HHSearch
69.42
28%
-24
- C2 -
-
1SDJ
-
YDDE_ECOLI
A:
[11-306]
H
M
K
P
Q
V
Y
H
V
D
A
F
T
S
Q
P
F
R
G
N
S
A
G
V
V
----
F
----
P
A
D
N
L
S
E
A
Q
M
Q
L
I
A
R
E
L
G
H
S
E
T
A
F
L
L
H
S
D
--
D
S
D
V
R
I
R
Y
F
T
P
T
V
E
V
P
I
C
G
H
A
T
V
A
A
H
Y
V
R
A
K
V
L
G
L
G
--
N
C
T
I
W
Q
T
S
L
A
G
K
H
R
V
T
I
---
E
K
H
N
-----
D
D
Y
R
I
S
L
E
Q
G
T
P
G
--
F
E
P
P
L
E
G
E
T
R
A
A
I
I
N
A
L
H
L
T
ED
D
I
L
P
G
L
--
P
------
I
Q
V
A
T
T
G
H
S
K
V
M
I
P
L
K
P
E
V
D
I
D
A
L
S
P
D
L
N
A
L
T
A
I
S
K
K
I
G
C
N
G
F
F
P
F
Q
I
R
P
G
---
K
-
N
E
T
D
G
R
M
F
S
P
A
I
G
I
V
E
D
P
V
T
G
N
A
N
G
P
M
G
A
W
L
V
H
H
N
V
L
P
H
D
G
N
V
L
R
V
K
--
G
H
Q
G
R
A
L
G
R
--------
D
G
M
I
E
V
T
V
-----
T
I
R
DNQP
E
-----
K
V
T
I
S
G
T
A
V
I
L
F
H
A
E
W
A
I
-
28
HHSearch
69.23
27%
-77
- C2 -
-
4DUN
2
?
A:
[3-261]
--
A
M
E
Y
Y
I
V
D
S
F
A
T
K
L
F
K
G
N
P
A
G
V
C
----
V
----
L
D
R
R
I
P
L
E
L
M
Q
K
I
A
E
E
N
N
L
P
E
T
A
F
V
V
K
G
---
K
G
N
Y
E
L
R
W
F
T
P
K
A
E
I
D
L
C
G
H
A
T
L
A
A
A
Y
V
I
S
N
F
I
D
V
N
--
V
K
K
I
D
F
F
T
Q
S
G
K
L
E
V
T
R
---
N
G
N
-------
L
Y
E
M
I
F
----
P
E
--
I
M
-
P
I
E
I
E
L
S
P
Q
Q
A
N
L
I
G
C
V
----------
P
------
S
D
V
--
Y
S
S
R
D
L
I
L
L
L
N
S
E
Q
E
V
I
N
Y
K
P
N
Y
A
Q
L
R
K
L
T
D
W
---
L
G
I
I
I
T
A
Q
G
-
S
---
N
-
T
D
F
V
S
R
Y
F
C
P
E
L
D
-
S
E
D
P
V
T
G
S
S
H
C
N
L
I
P
Y
W
S
E
K
L
G
------
K
H
K
M
V
--
A
A
Q
L
S
N
--
R
--------
G
G
I
I
Q
C
E
V
-----
L
K
D----
N
-----
T
V
K
I
S
G
E
A
V
L
F
M
Q
G
T
I
K
I
-
23
HHSearch
69.15
37%
19
- C2 -
-
1YM5
-
YHI9_YEAST
A:
[2-294]
T
L
M
V
P
F
K
Q
V
D
V
F
T
E
K
P
F
M
G
N
P
V
A
V
I
----
N
FLEI
D
E
N
E
V
S
Q
E
E
L
Q
A
I
A
N
W
T
N
L
S
E
T
T
F
L
F
K
P
S
D
K
K
Y
D
Y
K
L
R
I
F
T
P
R
S
E
L
P
F
A
G
H
P
T
I
G
S
C
K
A
F
L
E
F
T
K
N
T
T
-
A
T
S
L
V
Q
E
C
K
I
G
A
V
P
I
T
I
---
N
E
G
-------
L
I
S
F
K
A
P
M
--
A
D
--
Y
E
-
S
I
S
S
E
M
I
A
D
Y
E
K
A
I
G
L
K
--
F
---
I
K
--
P
------
P
A
L
L
H
T
G
P
E
W
I
V
A
L
V
E
D
A
E
T
C
F
N
A
N
P
N
F
A
M
L
A
H
Q
T
K
Q
N
D
H
V
G
I
I
L
A
G
P
K
K
E
A
A
I
K
-
N
S
Y
E
M
R
A
F
A
P
V
I
N
V
Y
E
D
P
V
C
G
S
G
S
V
A
L
A
R
Y
L
Q
E
V
Y
K
F
E
---
K
T
T
D
I
T
--
I
S
E
G
G
R
L
K
R
--------
N
G
L
M
L
A
S
I
-----
K
K
-----
E
ADN
S
T
S
Y
Y
I
A
G
H
A
T
T
V
I
D
G
K
I
K
V
-
26
HHSearch
67.82
28%
-71
- C2 -
-
1S7J
-
?
B:
[1-260]
-
M
S
Y
P
Y
Y
I
V
D
A
F
A
E
E
V
F
K
G
N
P
A
A
V
Y
----
V
----
L
E
K
W
L
P
E
A
V
M
Q
N
I
A
I
E
N
N
L
S
E
T
A
F
T
V
K
E
---
G
Q
S
Y
A
L
R
W
F
T
P
E
R
E
I
D
L
C
G
H
A
T
L
A
T
A
F
V
L
F
N
Y
Y
S
V
A
--
E
E
T
L
H
F
T
S
Q
S
G
P
L
A
V
T
K
---
K
E
E
-------
Y
Y
Y
L
D
F
P
Y--
I
L
--
P
E
-
R
I
P
--
I
L
P
E
Y
E
A
A
L
G
T
-----------
K
------
I
Y
E
A
Y
L
G
-
R
D
L
F
F
V
L
K
D
E
E
T
V
A
K
I
T
P
D
F
S
A
L
K
A
L
D
L
G
--
V
-
G
V
I
V
T
A
S
G
D
----
S
-
V
D
F
V
S
R
T
F
F
P
K
L
R
I
N
E
D
P
V
C
G
S
A
H
A
N
L
I
P
Y
W
G
K
R
L
N
------
Q
T
T
L
S
--
A
Y
Q
V
S
P
--
R
--------
G
G
F
L
T
C
E
V
-----
K
E
-----
N
-----
R
V
I
I
G
G
T
A
K
L
F
A
K
G
E
A
Y
L
-
3
PsiBlast_PDB
67.12
31%
-14
- C2 -
-
1QY9
2
YDDE_ECOLI
A:
[7-286]
-------
H
V
D
A
F
T
S
Q
P
F
R
G
N
S
A
G
V
V
----
F
----
P
A
D
N
L
S
E
A
Q
M
Q
L
I
A
R
E
L
G
H
S
E
T
A
F
L
L
H
S
D
D
S
--
D
V
R
I
R
Y
F
T
P
T
V
E
V
P
I
C
G
H
A
T
V
A
A
H
Y
--
V
R
A
K
V
L
G
L
G
N
C
T
I
W
Q
T
S
L
A
G
K
H
R
V
T
I
E
K
H
N
D
D
Y
R
----
I
S
L
E
Q
-
G
T
---
P
G
--
F
E
-
P
--
P
L
E
G
E
T
R
A
A
I
I
N
A
L
--
H
L
T
-
E
D
--
D
ILPGLP
I
Q
V
A
T
T
G
H
S
K
V
M
I
P
L
K
P
E
V
D
I
D
A
L
S
P
D
L
N
A
L
T
A
I
S
K
K
I
G
C
N
G
F
F
P
F
Q
I
R
P
G
-
K
N
E
---
T
D
G
R
M
F
S
P
A
I
G
I
V
E
D
P
V
T
G
N
A
N
G
P
M
G
A
W
L
V
H
H
N
V
L
P
H
--
D
G
N
V
L
R
V
K
G
H
Q
G
R
A
L
G
R
--------
D
G
M
I
E
V
T
V
T
I
R
DN
Q
P
-----
E
-----
K
V
T
I
S
G
T
A
V
----------
2
PsiBlast_PDB
66.33
31%
-12
- C2 -
-
1SDJ
-
YDDE_ECOLI
A:
[18-297]
-------
H
V
D
A
F
T
S
Q
P
F
R
G
N
S
A
G
V
V
----
F
----
P
A
D
N
L
S
E
A
Q
M
Q
L
I
A
R
E
L
G
H
S
E
T
A
F
L
L
H
S
D
D
S
--
D
V
R
I
R
Y
F
T
P
T
V
E
V
P
I
C
G
H
A
T
V
A
A
H
Y
--
V
R
A
K
V
L
G
L
G
N
C
T
I
W
Q
T
S
L
A
G
K
H
R
V
T
I
E
K
H
N
D
D
Y
R
----
I
S
L
E
Q
-
G
T
---
P
G
--
F
E
-
P
--
P
L
E
G
E
T
R
A
A
I
I
N
A
L
--
H
L
T
-
E
D
--
D
ILPGLP
I
Q
V
A
T
T
G
H
S
K
V
M
I
P
L
K
P
E
V
D
I
D
A
L
S
P
D
L
N
A
L
T
A
I
S
K
K
I
G
C
N
G
F
F
P
F
Q
I
R
P
G
-
K
N
E
---
T
D
G
R
M
F
S
P
A
I
G
I
V
E
D
P
V
T
G
N
A
N
G
P
M
G
A
W
L
V
H
H
N
V
L
P
H
--
D
G
N
V
L
R
V
K
G
H
Q
G
R
A
L
G
R
--------
D
G
M
I
E
V
T
V
T
I
R
DN
Q
P
-----
E
-----
K
V
T
I
S
G
T
A
V
----------