@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUY9: (2017-12-21 )
MNIHVEIDTHWCLEQLLQEGRITERDKLLVQTTNRQKDQLKWHPLQWIAHFNLKDQHHVQAHLSLNRLCQWFADRAQLPLFVIDPLKADVSALTQVMSQEFAIRNHILAVEVHADRIVIGTDQPFQTDWLNNLEKSLAPKKIERVFLNPEQLQRYLREYYQVSRAVNSAQKDAAHDRDNKGVEALLQLGDSQNPDANDQHIVKLVDWILQFAFEQSASDIHMEPRKDNGKVRFRIDGVLHTIYNMPSNTLTAVISRIKILGRLNVAEKRKPQDGRLKTRTPKGQETELRLSTLPTAFGEKLVMRIFDPDVLVRSFQQLGFDQSLLQQWQRITQNSHGIILVTGPTGSGKTTTLYSSLKQLATEQVNVCTIEDPIEMLEPSFNQMQVNHAIELGFADGVRALMRQDPDIIMIGEIRDQDTANMAIQAALTGHLVLSTLHTNDAPSSLTRLHDLGVQPFLTAATILGVLAQRLVRKLCPHCKQQTHINEDEWQHLTFDYIMEMPEKVYRAVGCEECRHTGYKGRIGIYEFMPVSLELKHLISSHATLNELRSQTKKESVEPLRIAGARKVIEGLTTLEEVLRVVPLN
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240..--..--...250.-......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360-.-...-....370.....----..380--.........---390---.......400.......410.......420.......430.......440......------.450------...------....460..-.....470.......480.......490.......--500...-....510.......520.......530.......540.......550.---......560.......570.......580...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
I
H
V
E
I
D
T
H
W
C
L
E
Q
L
L
QEGRITER
D
K
L
L
V
QTTNRQKDQLKWH
P
L
Q
W
I
A
HFNLK
D
Q
H
H
V
Q
A
H
L
S
L
N
R
L
C
Q
W
F
ADRAQL
P
L
F
V
IDP
L
K
A
D
V
S
A
L
T
Q
V
M
S
Q
E
F
A
IRN
H
I
L
A
V
E
V
HA
D
R
I
V
I
GTDQPF
Q
T
D
W
L
N
N
L
E
K
SL
A
P
K
K
I
E
R
VFL
N
P
E
Q
L
Q
R
Y
L
R
E
Y
Y
Q
V
S
R
A
V
N
S
A
Q
KDAAHDRDN
K
G
V
E
A
L
L
Q
LGDSQNPDA
N
D
Q
H
I
V
K
L
V
D
W
I
L
Q
F
A
F
EQSASDIHMEPRKDN
G
K
V
R
F
R
I
D
G
V
L
H
T
I
YN--MP--
S
N
T
L
T
A
V
-
I
S
R
I
K
I
L
GRLNVAEKRKPQDGRLKTRTPKGQE
T
E
L
R
L
S
TL
P
T
A
F
G
E
K
L
V
M
R
IF
D
P
D
V
L
V
R
S
F
Q
Q
LGF
D
Q
S
L
L
Q
Q
W
Q
R
ITQNSH
G
I
I
L
V
TGPTGSG
K
T
T
T
L
Y
S
S
L
K
Q
L
-
A
-
T
-EQV-
N
V
C
TIED
P
I
E
M
L----EPS----F
N
Q
M
Q
V
N
H
A
---
I
EL---G
F
A
D
G
V
R
A
L
M
RQDP
D
I
I
M
I
G
EIRDQDTA
N
M
A
I
Q
A
A
LTG
H
L
V
L
S
T
LHTNDA
P
S
S
L
T
R
------
L
H
DL------GV
Q
------
P
F
L
T
A
A
T
I
L
-
G
V
L
A
Q
R
L
V
R
K
L
C
P
H
C
KQQTHI
N
E
D
E
W
Q
H
L
T
F
D
Y
I
M
--
E
M
P
E
K
V
-
Y
R
AV
G
C
E
E
C
R
HTGYKGRI
G
I
Y
E
FMPV
S
L
E
L
K
H
L
I
S
SH
A
T
L
N
E
L
R
S
Q
T
K
---KESVE
P
L
R
I
A
G
A
R
K
V
I
E
G
L
T
T
L
E
E
V
L
R
VVPLN
50
HHSearch
88.16
46%
-101
- C3 -
-
5IT5
1
?
C:
[3-384]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
P
--
K
G
A
L
N
A
V
-
I
S
V
V
K
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
-
E
G
A
I
D
V
D
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
-
A
-
T
-
P
D
K
-
N
T
Q
T
I
E
D
P
V
E
Y
E
----
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
---
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
------
L
D
E
M
------
G
V
E
------
P
F
N
I
S
A
A
L
I
-
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
P
E
T
L
R
R
L
G
L
S
E
A
E
--
I
Q
G
A
R
L
-
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
---
R
K
G
M
K
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
A
R
T
I
--
49
HHSearch
88.05
46%
-103
- C3 -
-
5IT5
1
?
F:
[3-384]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
P
--
K
G
A
L
N
A
V
-
I
S
V
V
K
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
-
E
G
A
I
D
V
D
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
-
A
-
T
-
P
D
K
-
N
T
Q
T
I
E
D
P
V
E
Y
E
----
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
---
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
------
L
D
E
M
------
G
V
E
------
P
F
N
I
S
A
A
L
I
-
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
P
E
T
L
R
R
L
G
L
S
E
A
E
--
I
Q
G
A
R
L
-
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
---
R
K
G
M
K
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
A
R
T
I
--
29
PsiBlast_CBE
87.89
46%
-104
- C3 -
-
5IT5
1
?
D:
[5-380]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
P
--
K
G
A
L
N
A
V
-
I
S
V
V
K
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
-
G
A
I
D
V
D
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
-
A
-
T
-
P
D
K
-
N
T
Q
T
I
E
D
P
V
E
Y
E
----
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
---
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
------
L
D
E
M
------
G
V
E
------
P
F
N
I
S
A
A
L
I
-
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
P
E
T
L
R
R
L
G
L
S
E
A
E
--
I
Q
G
A
R
L
-
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
---
R
K
G
M
K
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
------
30
PsiBlast_CBE
87.74
46%
-102
- C3 -
-
5IT5
1
?
C:
[5-380]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
P
--
K
G
A
L
N
A
V
-
I
S
V
V
K
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
-
G
A
I
D
V
D
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
-
A
-
T
-
P
D
K
-
N
T
Q
T
I
E
D
P
V
E
Y
E
----
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
---
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
------
L
D
E
M
------
G
V
E
------
P
F
N
I
S
A
A
L
I
-
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
P
E
T
L
R
R
L
G
L
S
E
A
E
--
I
Q
G
A
R
L
-
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
---
R
K
G
M
K
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
------
32
PsiBlast_CBE
87.72
46%
-106
- C3 -
-
5IT5
1
?
A:
[5-380]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
P
--
K
G
A
L
N
A
V
-
I
S
V
V
K
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
-
G
A
I
D
V
D
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
-
A
-
T
-
P
D
K
-
N
T
Q
T
I
E
D
P
V
E
Y
E
----
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
---
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
------
L
D
E
M
------
G
V
E
------
P
F
N
I
S
A
A
L
I
-
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
P
E
T
L
R
R
L
G
L
S
E
A
E
--
I
Q
G
A
R
L
-
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
---
R
K
G
M
K
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
------
3
PsiBlast_PDB
87.72
46%
-104
- C3 -
-
5IT5
1
?
F:
[5-380]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
P
--
K
G
A
L
N
A
V
-
I
S
V
V
K
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
-
G
A
I
D
V
D
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
-
A
-
T
-
P
D
K
-
N
T
Q
T
I
E
D
P
V
E
Y
E
----
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
---
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
------
L
D
E
M
------
G
V
E
------
P
F
N
I
S
A
A
L
I
-
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
P
E
T
L
R
R
L
G
L
S
E
A
E
--
I
Q
G
A
R
L
-
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
---
R
K
G
M
K
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
------
31
PsiBlast_CBE
87.35
46%
-108
- C3 -
-
5IT5
1
?
B:
[5-380]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
P
--
K
G
A
L
N
A
V
-
I
S
V
V
K
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
-
G
A
I
D
V
D
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
-
A
-
T
-
P
D
K
-
N
T
Q
T
I
E
D
P
V
E
Y
E
----
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
---
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
------
L
D
E
M
------
G
V
E
------
P
F
N
I
S
A
A
L
I
-
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
P
E
T
L
R
R
L
G
L
S
E
A
E
--
I
Q
G
A
R
L
-
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
---
R
K
G
M
K
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
------
28
PsiBlast_CBE
85.82
46%
-104
- C3 -
-
5IT5
1
?
E:
[5-380]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
P
--
K
G
A
L
N
A
V
-
I
S
V
V
K
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
-
G
A
I
D
V
D
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
-
A
-
T
-
P
D
K
-
N
T
Q
T
I
E
D
P
V
E
Y
E
----
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
---
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
------
L
D
E
M
------
G
V
E
------
P
F
N
I
S
A
A
L
I
-
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
P
E
T
L
R
R
L
G
L
S
E
A
E
--
I
Q
G
A
R
L
-
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
---
R
K
G
M
K
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
------
45
HHSearch
83.47
35%
-107
- C3 -
-
5TSH
1
?
C:
[200-586]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
P
--
L
K
L
K
N
A
I
-
T
S
R
I
K
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
----
Q
D
M
D
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
--
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
-
N
-
K
-
T
T
E
-
N
I
S
T
A
E
D
P
V
E
F
N
----
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
---
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
------
L
L
N
M
------
G
V
E
------
P
F
L
V
A
S
A
V
N
-
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
P
I
Q
A
L
I
D
A
G
V
S
P
D
E
--
G
P
S
Y
V
C
-
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
---
R
L
G
I
K
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
T
V
A
-
27
PsiBlast_CBE
82.46
38%
-90
- C3 -
-
5TSG
1
?
C:
[201-583]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
P
--
L
K
L
K
N
A
I
-
T
S
R
I
K
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
-------
M
D
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
N
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
-
N
-
K
-
T
T
E
-
N
I
S
T
A
E
D
P
V
E
F
N
----
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
---
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
------
L
L
N
M
------
G
V
E
------
P
F
L
V
A
S
A
V
N
-
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
PD
E
G
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
---
R
L
G
I
K
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
----
1
PsiBlast_PDB
82.17
38%
-90
- C3 -
-
5TSG
1
?
B:
[201-583]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
P
--
L
K
L
K
N
A
I
-
T
S
R
I
K
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
L
----
D
M
D
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
N
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
-
N
-
K
-
T
T
E
-
N
I
S
T
A
E
D
P
V
E
F
N
----
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
---
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
------
L
L
N
M
------
G
V
E
------
P
F
L
V
A
S
A
V
N
-
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
PD
E
G
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
---
R
L
G
I
K
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
----
21
PsiBlast_CBE
81.89
38%
-90
- C3 -
-
5TSH
1
?
F:
[200-583]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
P
--
L
K
L
K
N
A
I
-
T
S
R
I
K
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
------
M
D
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
N
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
-
N
-
K
-
T
T
E
-
N
I
S
T
A
E
D
P
V
E
F
N
----
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
---
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
------
L
L
N
M
------
G
V
E
------
P
F
L
V
A
S
A
V
N
-
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
PD
E
G
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
---
R
L
G
I
K
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
----
24
PsiBlast_CBE
81.01
38%
-90
- C3 -
-
5TSH
1
?
C:
[200-583]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
P
--
L
K
L
K
N
A
I
-
T
S
R
I
K
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
----
Q
D
M
D
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
--
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
-
N
-
K
-
T
T
E
-
N
I
S
T
A
E
D
P
V
E
F
N
----
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
---
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
------
L
L
N
M
------
G
V
E
------
P
F
L
V
A
S
A
V
N
-
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
PD
E
G
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
---
R
L
G
I
K
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
----
2
PsiBlast_PDB
80.97
38%
-90
- C3 -
-
5TSH
1
?
A:
[202-583]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
P
--
L
K
L
K
N
A
I
-
T
S
R
I
K
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
-------
M
D
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
----
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
-
N
-
K
-
T
T
E
-
N
I
S
T
A
E
D
P
V
E
F
N
----
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
---
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
------
L
L
N
M
------
G
V
E
------
P
F
L
V
A
S
A
V
N
-
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
PD
E
G
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
---
R
L
G
I
K
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
----
25
PsiBlast_CBE
80.96
38%
-96
- C3 -
-
5TSH
1
?
B:
[201-583]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
P
--
L
K
L
K
N
A
I
-
T
S
R
I
K
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
--------
D
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
----
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
-
N
-
K
-
T
T
E
-
N
I
S
T
A
E
D
P
V
E
F
N
----
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
---
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
------
L
L
N
M
------
G
V
E
------
P
F
L
V
A
S
A
V
N
-
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
PD
E
G
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
---
R
L
G
I
K
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
----
22
PsiBlast_CBE
80.64
38%
-91
- C3 -
-
5TSH
1
?
E:
[202-583]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
P
--
L
K
L
K
N
A
I
-
T
S
R
I
K
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
L
G
G
G
Q
D
M
D
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
N
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
-
N
-
K
-
T
T
E
-
N
I
S
T
A
E
D
P
V
E
F
N
----
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
---
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
------
L
L
N
M
------
G
V
E
------
P
F
L
V
A
S
A
V
N
-
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
PD
E
G
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
---
R
L
G
I
K
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
----
5
PsiBlast_PDB
80.13
45%
-
- C3 -
-
4KSS
-
GSPE_VIBCH
A:
[121-514]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
I
I
K
L
I
N
A
M
L
G
E
A
I
K
E
G
A
S
D
I
H
I
E
T
F
E
K
T
L
S
I
R
F
R
V
D
G
V
L
R
E
V
L
---
A
P
--
S
R
K
L
S
S
L
L
V
S
R
V
K
V
M
A
K
L
D
I
A
E
K
R
V
P
Q
D
G
R
I
S
L
------
A
V
D
V
R
V
S
T
M
P
S
S
H
G
E
R
V
V
M
R
L
L
D
K
-----
D
L
H
S
L
G
M
T
A
H
N
H
D
N
F
R
R
L
I
K
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
-
N
-
S
-
S
E
R
-
N
I
L
T
V
E
D
P
I
E
F
D
----
I
D
G
----
I
G
Q
T
Q
V
N
P
R
---
V
D
M
---
T
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
------
L
R
D
M
------
G
I
E
------
P
F
L
I
S
S
S
L
L
-
G
V
L
A
Q
R
L
V
R
T
L
C
P
D
C
K
E
P
--
Y
E
A
D
K
E
Q
R
K
L
F
-------
E
P
L
I
L
-
Y
R
A
T
G
C
P
K
C
N
H
K
G
Y
R
G
R
T
G
I
H
E
L
L
L
V
D
D
A
L
Q
E
L
I
H
S
E
A
G
E
Q
A
M
E
K
H
I
R
---
A
-
T
T
P
S
I
R
D
D
G
L
D
K
V
R
Q
G
I
T
S
L
E
E
V
M
R
V
----
23
PsiBlast_CBE
79.75
38%
-93
- C3 -
-
5TSH
1
?
D:
[202-583]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
P
--
L
K
L
K
N
A
I
-
T
S
R
I
K
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
-----
D
M
D
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
--
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
-
N
-
K
-
T
T
E
-
N
I
S
T
A
E
D
P
V
E
F
N
----
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
---
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
------
L
L
N
M
------
G
V
E
------
P
F
L
V
A
S
A
V
N
-
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
PD
E
G
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
---
R
L
G
I
K
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
----
4
PsiBlast_PDB
79.75
45%
-
- C3 -
-
4KSR
-
GSPE_VIBCH
A:
[121-516]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
I
I
K
L
I
N
A
M
L
G
E
A
I
K
E
G
A
S
D
I
H
I
E
T
F
E
K
T
L
S
I
R
F
R
V
D
G
V
L
R
E
V
L
---
A
P
--
S
R
K
L
S
S
L
L
V
S
R
V
K
V
M
A
K
L
D
I
A
E
K
R
V
P
Q
D
G
R
I
S
L
------
A
V
D
V
R
V
S
T
M
P
S
S
H
G
E
R
V
V
M
R
L
L
D
K
-----
D
L
H
S
L
G
M
T
A
H
N
H
D
N
F
R
R
L
I
K
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
-
N
-
S
-
S
E
R
-
N
I
L
T
V
E
D
P
I
E
F
D
----
I
D
G
----
I
G
Q
T
Q
V
N
P
R
---
V
D
M
---
T
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
------
L
R
D
M
------
G
I
E
------
P
F
L
I
S
S
S
L
L
-
G
V
L
A
Q
R
L
V
R
T
L
C
P
D
C
K
E
P
--
Y
E
A
D
K
E
Q
R
K
L
F
-------
E
P
L
I
L
-
Y
R
A
T
G
C
P
K
C
N
H
K
G
Y
R
G
R
T
G
I
H
E
L
L
L
V
D
D
A
L
Q
E
L
I
H
S
E
A
G
E
Q
A
M
E
K
H
I
R
---
A
-
T
T
P
S
I
R
D
D
G
L
D
K
V
R
Q
G
I
T
S
L
E
E
V
M
R
V
----
26
PsiBlast_CBE
79.39
38%
-81
- C3 -
-
5TSG
1
?
D:
[201-583]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
P
--
L
K
L
K
N
A
I
-
T
S
R
I
K
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
L
G
---
D
M
D
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
N
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
-
N
-
K
-
T
T
E
-
N
I
S
T
A
E
D
P
V
E
F
N
----
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
---
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
------
L
L
N
M
------
G
V
E
------
P
F
L
V
A
S
A
V
N
-
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
-
V
S
PD
E
G
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
---
R
L
G
I
K
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
----
52
HHSearch
56.69
32%
7
- C3 -
-
5FL3
2
?
A:
[10-351]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
L
V
E
M
L
K
A
M
V
Q
A
R
A
S
D
I
H
L
Q
A
G
---
A
P
P
T
V
R
I
D
G
K
L
R
P
F
G
N
R
P
L
T
--
P
K
E
V
E
A
I
-
A
R
A
L
L
T
P
E
Q
L
E
E
L
E
Y
R
K
E
M
D
F
A
Y
T
---
I
P
-
G
V
A
R
F
R
C
N
L
L
R
Q
R
G
S
F
G
L
V
M
R
V
V
S
E
V
--
I
P
S
F
E
A
L
G
L
P
R
E
V
M
E
S
---
L
A
A
K
E
R
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
L
I
D
H
I
-
N
-
L
H
Y
A
K
-
N
I
I
T
I
E
D
P
I
E
F
L
----
H
K
H
----
K
K
S
L
V
V
Q
R
E
V
GL
D
T
D
---
S
F
Y
T
G
L
K
Y
A
L
R
Q
D
P
D
V
I
M
V
G
E
M
R
D
R
E
T
V
E
A
A
L
M
A
A
Q
T
G
H
L
V
L
S
T
L
H
T
L
D
A
W
R
T
I
N
R
------
I
I
D
F
------
F
P
L
HE
H
R
Q
V
R
V
L
L
A
E
S
L
L
-
G
I
L
S
Q
R
L
L
P
K
A
D
G
---------------------------------------------
Q
G
R
V
L
A
L
E
I
L
I
A
T
P
Y
V
R
E
L
L
K
D
E
E
K
T
P
Q
I
K
E
A
M
M
E
GS
L
Y
G
M
R
T
F
D
Q
H
L
V
E
L
Y
T
E
G
L
I
S
L
E
D
A
L
S
A
A
T
--
51
HHSearch
51.57
30%
18
* C3 *
-
3JVV
1
PILT_PSEAE
C:
[2-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
E
L
L
A
F
S
A
K
Q
G
A
S
D
L
H
L
S
A
G
---
L
P
P
M
I
R
V
D
G
D
V
R
R
I
N
L
PP
L
E
--
H
K
Q
V
H
A
L
-
I
Y
D
I
M
N
D
K
Q
--
R
K
D
F
E
E
F
L
E
T
D
F
S
F
E
-
V
P
-
G
V
A
R
F
R
V
N
A
F
N
Q
N
R
G
A
G
A
V
F
R
T
I
P
S
K
--
V
L
T
M
E
E
L
G
M
G
E
----
V
F
K
R
V
S
D
V
P
R
G
L
V
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
M
L
D
Y
L
-
N
-
N
T
K
Y
H
-
H
I
L
T
I
E
D
P
I
E
F
V
----
H
E
S
KKCL
V
N
Q
R
E
V
H
R
----
D
T
L
---
G
F
S
E
A
L
R
S
A
L
R
E
D
P
D
I
I
L
V
G
E
M
R
D
L
E
T
I
R
L
A
L
T
A
A
E
T
G
H
L
V
F
G
T
L
H
T
T
S
A
A
K
T
I
D
R
------
V
V
D
V
------
F
P
A
EEKAMV
R
S
M
L
S
E
S
L
Q
-
S
V
I
S
Q
T
L
I
K
K
I
G
----------------------------------------------
G
G
R
V
A
A
H
E
I
M
I
G
T
P
A
I
R
N
L
I
R
E
D
K
-
V
A
Q
M
Y
S
A
I
Q
TGG
S
L
G
M
Q
T
L
D
M
C
L
K
-----
G
L
I
S
R
E
N
A
R
E
K
A
K
--
6
PsiBlast_PDB
48.64
34%
-11
- C3 -
-
5FL3
2
?
A:
[10-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
L
V
E
M
L
K
A
M
V
Q
----
A
R
A
S
D
I
H
L
Q
A
---
G
A
P
P
T
V
R
I
D
G
K
L
R
P
F
G
N
--
R
P
L
T
P
K
E
V
E
A
I
-
A
R
A
L
L
T
P
E
Q
L
E
E
L
E
Y
R
K
E
M
D
--
F
A
Y
T
I
P
G
V
A
R
F
R
C
N
L
L
R
Q
R
G
S
F
G
--
L
V
M
R
V
V
S
E
--
V
I
P
S
F
E
A
L
G
L
P
R
E
V
M
E
S
---
L
A
A
K
E
R
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
L
I
D
H
I
-
N
-
L
-
H
Y
A
K
N
I
I
T
I
E
D
P
I
E
F
L
----
H
K
H
----
K
K
S
L
V
V
Q
R
E
---
V
G
L
DTD
S
F
Y
T
G
L
K
Y
A
L
R
Q
D
P
D
V
I
M
V
G
E
M
R
D
R
E
T
V
E
A
A
L
M
A
A
Q
T
G
H
L
V
L
S
T
L
H
T
L
D
A
W
R
T
I
N
R
I
I
D
FFP
L
H
E
H
------
R
Q
V
------
R
V
L
L
A
E
S
L
L
-
G
I
L
S
Q
R
L
L
P
K
---------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
45.92
37%
-23
- C3 -
-
3JVV
1
PILT_PSEAE
C:
[91-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
G
A
V
F
R
T
I
P
S
K
V
L
--
T
M
E
E
L
G
M
G
E
V
----
F
K
R
V
S
D
V
P
R
G
L
V
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
M
L
D
Y
L
-
N
N
T
-
K
Y
H
-
H
I
L
T
I
E
D
P
I
E
F
V
----
H
E
S
KKCL
V
N
Q
R
E
V
-
H
R
---
D
T
L
---
G
F
S
E
A
L
R
S
A
L
R
E
D
P
D
I
I
L
V
G
E
M
R
D
L
E
T
I
R
L
A
L
T
A
A
E
T
G
H
L
V
F
G
T
L
H
T
T
S
A
A
K
T
I
D
R
------
V
V
D
V
FPAEEK
A
M
V
------
R
S
M
L
S
E
S
L
Q
-
S
V
I
S
Q
T
L
I
K
K
I
--------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
42.44
40%
-22
- C3 -
-
2EWW
1
?
A:
[119-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
K
L
G
L
P
D
K
V
L
E
L
C
H
R
----
K
M
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
I
D
Y
I
N
Q
-
T
-
K
S
Y
-
H
I
I
T
I
E
D
P
I
E
Y
V
F
K
HK
K
S
I
----
V
N
Q
R
E
V
G
E
D
---
T
K
----
S
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
------
I
V
D
I
FPLNQ-
Q
E
Q
------
V
R
I
V
L
S
F
I
L
Q
G
I
I
S
Q
R
L
L
P
K
I
--------------------------------------------------------------------------------------------------------------------