@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VV20: (2017-12-21 )
MPPLPNSHMFKMSHLKKKISLESYYSAADILKKLEELTGLVYLQDDNNPVIGFLPKNYLIVQNNQNFLFTKTDLNKYKFSSYIENLLDFTQFQSQELKNSNREKISFKGGYIGFISYDFSAHQFINNQSHKQPSLFIGSYYSFIKKINNEWYFFSDENNAFEIFNYLSALLNKPSSKLQKNNFKLEQNIHPRWSKNTYLTAFHKIQEYIKAGDCYQINLTQEFKANFTGSLLNKADELWNLTNAPYSGYLKLTEFELLSCSPELFIEFNVDKQIKTRPIKGTMPRYENKEQDLLSKQTLKNSKKDQAENVMIVDLLRNDLSIYANTGSVKTTKLFEIESFNQVHHMVSEITATLKNDINPIQMLLTALPGGSITGAPKIRAMQIIAELEGAPRGAYCGTLGYFNFDGTGRWNILIRSFQQHQNQLSIWAGGGITIASEAEAEYQESLDKISAMLNLMNSTAE
Atome Classification :
(20 SA)
-.........10........20........30....-.------..--.40......-------..50........60........70.....--------------------------------------...80........90......-..100.......110......----.120.....----..130.......140........150.........160---......--------...170......--.----180-.......190.......200.......210.......220......--.230...--....240.......250.------...----...260.......-270........280.......------290---........--300........310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MPPLPN
S
H
M
F
K
M
S
H
L
K
K
K
I
S
L
E
S
Y
Y
S
A
A
D
I
L
K
K
L
E
-
E
------LT--
G
L
V
Y
L
QDDN-------N
P
V
I
G
F
LPK
N
Y
L
I
V
QNNQ
N
F
L
F
T
KTDL
N
K
--------------------------------------
Y
K
F
S
S
Y
I
E
N
L
L
D
F
T
Q
F
Q
S
Q
E
L
-KNSNR
E
K
I
S
FKG
G
Y
I
G
F
I
S
YD----F
S
A
H
Q
F
INN----QSHKQPSL
F
I
G
S
Y
-
Y
S
F
I
K
K
INN
E
--
W
Y
F
FSDEN
N
A
-----
F
E
I
F
N
Y
--------
L
S
A
L
LNKPS
S
K
L--Q----KNN-
F
K
LEQNIHPRWSKN
T
Y
L
T
A
F
H
K
I
Q
E
Y
I
KAG
D
C
Y
Q
I
NL
T
Q
E
F
KANF
T
--
G
S
L
L
N
K
A
--
D
E
L
WNLTNAPYS
G
Y
L
K
L
T
------
E
F
E
----
L
LSCS
P
E
L
F
I
E
FN-V-DKQIKTRPIKGTMPRYE
N
K
------
E
Q
----
D
L
L
S
K
Q
T
L--K-NSKKDQAE
N
V
M
I
V
D
L
LRND
L
S
I
Y
ANTGS
V
K
T
T
K
L
F
E
I
E
S
F
N
Q
V
H
H
M
V
S
E
I
T
A
T
L
KNDI
N
P
I
Q
M
L
L
T
ALPGGSITGAP
K
I
R
A
M
Q
I
I
A
E
LEGAPRGAYCGTLGYFNFDGTG
R
W
N
I
L
I
R
S
F
Q
Q
H
QNQ
L
S
I
WAGG
G
I
T
I
A
S
E
A
E
A
E
Y
Q
E
S
L
D
K
I
S
A
M
L
N
L
M
NSTAE
4
PsiBlast_PDB
81.60
35%
-69
- C1 -
-
1QDL
-
TRPE_SULSO
A:
[78-414]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
G
G
M
I
G
Y
I
S
Y
D
------
A
V
R
F
W
E
K
----
I
R
D
L
K
P
A
A
E
D
W
P
Y
-
A
E
F
F
T
P
D
N
I
I
--
I
Y
----
D
H
N
E
-----
G
K
V
--
Y
--------
V
N
A
D
L
S
S
V
G
G
C
G
--
D
----
I
G
E
-
F
K
V
-
S
F
Y
D
E
S
L
N
K
N
S
Y
E
R
I
V
S
E
S
L
E
Y
I
R
S
G
Y
I
F
Q
V
V
L
S
R
F
Y
R
Y
I
F
S
--
G
D
P
L
R
I
Y
--
Y
N
L
R
R
I
N
P
S
P
Y
M
F
Y
L
K
F
D
------
E
K
Y
----
L
I
G
S
S
P
E
L
L
F
R
V
Q
---
D
N
I
V
E
T
Y
P
I
A
G
T
R
P
R
G
A
D
Q
------
E
E
----
D
L
K
L
E
L
E
L
--
M
-
N
S
E
K
D
K
A
E
H
L
M
L
V
D
L
A
R
N
D
L
G
K
V
C
V
P
G
T
V
K
V
P
E
L
M
Y
V
E
K
Y
S
H
V
Q
H
I
V
S
K
V
I
G
T
L
K
K
K
Y
N
A
L
N
V
L
S
A
T
F
P
A
G
T
V
S
G
A
P
K
P
M
A
M
N
I
I
E
T
L
E
E
Y
K
R
G
P
Y
A
G
A
V
G
F
I
S
A
D
G
N
A
E
F
A
I
A
I
R
T
A
F
L
N
K
E
L
L
R
I
H
A
G
A
G
I
V
Y
D
S
N
P
E
S
E
Y
F
E
T
E
H
K
L
K
A
L
---------
32
HHSearch
78.42
33%
13
- C1 -
-
1K0E
1
PABB_ECOLI
B:
[3-452]
---------
T
L
S
P
A
V
I
--
T
L
L
W
R
Q
D
A
-
A
E
F
Y
F
S
R
L
S
-
H
------
L
P
--
W
A
M
L
L
H
S
G
Y
ADHPYSR
F
D
I
V
V
A
E
P
I
C
T
L
T
T
F
G
K
E
T
V
V
S
E
S
E
K
--
R
--------------------------------------
T
T
T
T
D
D
P
L
Q
V
L
Q
Q
V
L
D
R
A
D
I
R
--
P
T
H
N
E
D
L
P
F
Q
G
G
A
L
G
L
F
G
Y
D
----
L
G
R
R
F
E
S
L
P
E
IAE
Q
D
I
V
L
P
D
M
A
V
G
I
Y
-
D
W
A
L
I
V
D
H
Q
R
H
T
V
S
L
L
S
H
N
D
V
N
------
A
R
R
A
W
--------
L
E
S
Q
Q
F
S
-------
P
----
Q
E
D
-
F
T
L
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
S
--
G
D
E
W
Q
A
F
--
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
E
------
Q
G
A
----
I
L
S
L
S
P
E
R
F
I
L
C
D
-
N
-
S
-
E
I
Q
T
R
--------------------------------------
A
K
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
--------------
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
Q
L
E
----
33
HHSearch
78.37
33%
23
- C1 -
-
1K0E
2
PABB_ECOLI
A:
[3-452]
---------
T
L
S
P
A
V
I
--
T
L
L
W
R
Q
D
A
-
A
E
F
Y
F
S
R
L
S
-
H
------
L
P
--
W
A
M
L
L
H
S
G
Y
ADHPYSR
F
D
I
V
V
A
E
P
I
C
T
L
T
T
F
G
K
E
T
V
V
S
E
S
E
K
--
R
--------------------------------------
T
T
T
T
D
D
P
L
Q
V
L
Q
Q
V
L
D
R
A
D
I
R
--
P
T
H
N
E
D
L
P
F
Q
G
G
A
L
G
L
F
G
Y
D
----
L
G
R
R
F
E
S
L
P
EIAE
Q
D
I
V
L
P
D
M
A
V
G
I
Y
-
D
W
A
L
I
V
D
H
Q
R
H
T
V
S
L
L
S
H
N
D
V
N
------
A
R
R
A
W
--------
L
E
S
Q
Q
F
S
-------
P
----
Q
E
D
-
F
T
L
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
S
--
G
D
E
W
Q
A
F
--
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
E
------
Q
G
A
----
I
L
S
L
S
P
E
R
F
I
L
C
D
-
N
-
S
-
E
I
Q
T
R
P
I
K
G
T
L
P
R
--------------------------
A
-
N
S
A
K
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
F
V
V
E
P
F
P
A
V
H
H
L
V
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
Q
L
E
----
36
HHSearch
77.79
24%
22
- C1 -
-
5CWA
4
TRPE_MYCTO
A:
[21-506]
--------
A
E
H
R
V
V
P
V
T
R
K
V
L
A
D
S
E
T
-
P
L
S
A
Y
R
K
L
A
-
A
N-----
R
P
--
G
T
F
L
L
E
S
A
E
NGRSWSR
W
S
F
I
G
A
G
A
P
T
A
L
T
V
R
E
G
Q
A
V
W
L
G
A
V
P
-
K
D
--------------------------------------
A
P
T
G
G
D
P
L
R
A
L
Q
V
T
L
E
L
L
A
T
A
D----
P
G
L
P
P
L
S
G
G
M
V
G
F
F
A
Y
D
----
M
V
R
R
L
E
R
L
P
ERAV
D
D
L
C
L
P
D
M
L
L
L
L
A
-
T
D
V
A
A
V
D
H
H
E
G
T
I
T
L
I
A
N
A
V
N
W
NGT--
D
E
R
V
D
W
A
Y
D
D
A
V
A
R
L
D
V
M
T
A
A
L
G
Q
P
L
P
S
T
----
V
A
T
F
S
R
P
E
P
R
H
R
A
Q
R
T
V
E
E
Y
G
A
I
V
E
Y
L
V
D
Q
I
A
A
G
E
A
F
Q
V
V
P
S
Q
R
F
E
M
D
T
D
--
V
D
P
I
D
V
Y
--
R
I
L
R
V
T
N
P
S
P
Y
M
Y
L
L
Q
V
P
N
SDGAV
D
F
S
----
I
V
G
S
S
P
E
A
L
V
T
V
H
-
E
-
G
-
W
A
T
T
H
P
I
A
G
T
R
W
R
G
R
T
D
------
D
E
----
D
V
L
L
E
K
E
L
--
L
-
A
D
D
K
E
R
A
E
H
L
M
L
V
D
L
G
R
N
D
L
G
R
V
C
T
P
G
T
V
R
V
E
D
Y
S
H
I
E
R
Y
S
H
V
M
H
L
V
S
T
V
T
G
K
L
G
E
G
R
T
A
L
D
A
V
T
A
C
F
P
A
G
T
L
S
G
A
P
K
V
R
A
M
E
L
I
E
E
V
E
K
T
R
R
G
L
Y
G
G
V
V
G
Y
L
D
F
A
G
N
A
D
F
A
I
A
I
R
T
A
L
M
R
N
G
T
A
Y
V
Q
A
G
G
G
V
V
A
D
S
N
G
S
Y
E
Y
N
E
A
R
N
K
A
R
A
V
L
N
A
I
A
A
A
E
-
39
HHSearch
74.85
31%
10
* C1 *
-
1QDL
-
TRPE_SULSO
A:
[10-420]
-------------------------
A
S
P
F
E
V
F
K
C
I
E
R
D
------
F
K
--
V
A
G
L
L
E
S
I
-R------
Y
S
V
I
A
W
S
T
N
G
Y
L
K
I
H
--------------------------------------------------------
D
D
P
V
N
I
L
N
G
Y
L
K
D
L
K
L
-----
A
D
I
P
G
L
F
K
G
G
M
I
G
Y
I
S
Y
D
----
A
V
R
F
W
E
K
I
R
DLKP
A
A
E
D
W
P
Y
A
E
F
F
T
P
-
D
N
I
I
I
Y
D
H
N
E
G
K
V
Y
V
N
A
D
L
S
S
V
------
G
---
G
--------
C
G
----
D
I
-------------
G
-
E
F
K
V
S
F
Y
D
E
S
L
N
K
N
S
Y
E
R
I
V
S
E
S
L
E
Y
I
R
S
G
Y
I
F
Q
V
V
L
S
R
F
Y
R
Y
I
F
S
--
G
D
P
L
R
I
Y
--
Y
N
L
R
R
I
N
P
S
P
Y
M
F
Y
L
K
F
D
------
E
K
Y
----
L
I
G
S
S
P
E
L
L
F
R
V
Q
-
D
-
N
-
I
V
E
T
Y
P
I
A
G
T
R
P
R
G
A
D
Q
------
E
E
----
D
L
K
L
E
L
E
L
--
M
-
N
S
E
K
D
K
A
E
H
L
M
L
V
D
L
A
R
N
D
L
G
K
V
C
V
P
G
T
V
K
V
P
E
L
M
Y
V
E
K
Y
S
H
V
Q
H
I
V
S
K
V
I
G
T
L
K
K
K
Y
N
A
L
N
V
L
S
A
T
F
P
A
G
T
V
S
G
A
P
K
P
M
A
M
N
I
I
E
T
L
E
E
Y
K
R
G
P
Y
A
G
A
V
G
F
I
S
A
D
G
N
A
E
F
A
I
A
I
R
T
A
F
L
N
K
E
L
L
R
I
H
A
G
A
G
I
V
Y
D
S
N
P
E
S
E
Y
F
E
T
E
H
K
L
K
A
L
K
T
A
I
G
V
---
34
HHSearch
73.78
25%
20
- C1 -
-
4GRH
5
?
A:
[2-454]
--------
S
H
G
T
H
A
P
L
I
H
P
L
P
H
P
-----
I
D
L
L
A
L
Q
Q
-
H
------
D
P
AR
F
P
L
L
M
E
S
T
A
SQ
G
R
---
W
S
L
L
L
V
A
Q
G
D
G
L
R
L
D
A
D
G
Q
V
R
D
Q
H
----
D
--------------------------------------
L
V
Q
P
G
T
F
L
Q
A
L
D
R
A
W
Q
H
E
R
L
S
--
H
D
G
S
H
S
L
P
F
R
G
G
W
A
L
M
L
D
Y
E
----
V
A
S
Q
I
E
P
V
L
P
A
R
A
R
G
D
G
R
P
T
A
L
A
L
R
C
-
P
A
A
V
L
H
D
H
H
N
E
A
S
F
V
I
A
E
A
G
E
Q
------
A
L
L
D
A
--------
L
V
A
L
A
S
A
A
L
P
E
---
A
-----
G
Q
-
G
W
Q
P
P
Q
A
V
G
E
D
A
P
Q
R
F
T
D
G
V
R
R
V
I
E
Y
L
R
A
G
D
V
F
Q
V
N
L
S
R
R
W
N
A
Q
F
A
AP
V
S
P
Q
A
L
Y
--
A
Q
L
R
R
A
N
P
A
P
F
A
G
L
F
S
A
H
------
G
R
H
----
V
V
S
S
S
P
E
R
L
V
S
V
H
-
A
-
G
-
H
A
Q
T
R
P
I
A
G
T
R
P
R
F
E
G
-------
D
D
--------------------
E
R
A
E
H
V
M
L
I
D
L
E
R
N
D
L
G
R
I
C
L
P
G
T
V
V
V
D
E
L
M
T
V
E
S
Y
A
H
V
H
H
I
V
S
N
V
S
G
H
L
R
P
E
V
T
P
G
E
V
I
A
A
T
F
P
G
G
T
I
T
G
C
P
K
V
R
C
M
Q
I
I
S
E
L
E
Q
V
P
R
G
A
Y
T
G
A
F
G
W
L
N
R
D
G
D
L
D
L
N
I
L
I
R
T
A
E
V
D
G
H
E
V
S
F
R
T
G
A
G
I
V
V
D
S
D
P
D
K
E
L
D
E
T
R
A
K
A
R
G
L
L
R
A
L
G
----
26
Fugue
73.11
31%
7
- C1 -
-
1K0E
2
PABB_ECOLI
A:
[3-453]
T
L
S
P
A
V
I
T
L
L
W
R
Q
D
A
A
E
F
Y
F
S
R
L
S
H
L
P
W
A
M
L
L
H
S
G
Y
-
A
------
D
H
-------
P
Y
S
R
-------
F
D
I
V
V
A
E
P
I
C
T
L
T
T
F
G
K
E
T
V
V
S
E
S
E
K
R
T
T
--------------------------------------
T
T
-
D
D
P
L
Q
V
L
Q
Q
V
L
D
R
A
D
I
R
P
-
T
H
N
--
E
D
L
P
F
Q
G
G
A
L
G
L
F
G
Y
D
----
L
G
R
R
F
E
S
L
P
----
E
I
A
E
Q
D
I
V
L
P
D
M
A
-
V
G
I
Y
----
D
W
--
A
L
I
V
D
H
Q
R
H
T
-----
V
S
L
L
S
H
--------
N
D
V
N
A
R
R
A
W
L
E
S
--
Q
QFSP
Q
E
D
-
F
T
L
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
S
--
G
D
E
W
Q
A
F
--
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
E
------
Q
G
A
----
I
L
S
L
S
P
E
R
F
I
L
C
D
---
N
S
E
I
Q
T
R
P
I
K
G
T
L
P
R
--------------------------
A
-
N
S
A
K
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
F
V
V
E
P
F
P
A
V
H
H
L
V
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
Q
L
E
K
---
40
HHSearch
70.42
21%
-2
- C1 -
-
1I1Q
1
TRPE_SALTY
A:
[7-514]
------------
T
L
E
L
L
T
C
D
A
A
Y
R
E
N
-
P
T
A
L
F
H
Q
V
C
G
D
------
R
P
--
A
T
L
L
L
E
S
A
D
IDSKDD
L
K
S
L
L
L
V
D
S
A
L
R
I
T
A
L
G
D
T
V
T
I
Q
A
L
S
D
N
G
A
S
L
L
P
L
L
D
T
A
LPAG
V
E
N
D
V
L
PA
G
R
V
L
R
F
P
P
V
S
PLLD
E
N
A
R
L
C
S
L
S
V
F
D
A
F
R
L
L
Q
G
V
V
N
I
P
------
T
Q
E
R
E
A
M
F
F
G
G
L
F
A
Y
D
----
L
V
A
G
F
E
A
L
P
HLE-
A
G
N
N
C
P
D
Y
C
F
Y
L
A
-
E
T
L
M
V
I
D
H
Q
K
K
S
T
R
I
Q
A
S
L
F
T
A
S
D
R
E
K
Q
R
L
N
A
R
--------
L
A
Y
L
S
Q
Q
L
T
Q
P
A
--
P
P
L
--
P
V
T
-
P
V
P
D
M
R
C
E
C
N
Q
S
D
D
A
F
G
A
V
V
R
Q
L
Q
K
A
I
R
A
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
P
---
S
P
L
A
A
Y
--
Y
V
L
K
K
S
N
P
S
P
Y
M
F
F
M
Q
D
N
------
D
F
T
----
L
F
G
A
S
P
E
S
S
L
K
Y
D
-
A
A
S
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
A
DGTLD
R
D
L
----
D
S
R
I
E
L
D
M
--
R
-
T
D
H
K
E
L
S
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
T
P
G
S
R
Y
V
A
D
L
T
K
V
D
R
Y
S
Y
V
M
H
L
V
S
R
V
V
G
E
L
R
H
D
L
D
A
L
H
A
Y
R
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
D
A
E
G
Q
R
R
G
S
Y
G
G
A
V
G
Y
F
T
A
H
G
D
L
D
T
C
I
V
I
R
S
A
L
V
E
N
G
I
A
T
V
Q
A
G
A
G
I
V
L
D
S
V
P
Q
S
E
A
D
E
T
R
N
K
A
R
A
V
L
R
A
I
A
T
A
H
-
37
HHSearch
69.94
26%
9
- C1 -
-
5KCK
2
?
A:
[4-449]
----------------
E
R
I
I
H
G
D
V
L
S
-
P
I
L
A
Y
M
R
L
K
-
G
-------
Q
--
H
K
V
I
L
E
S
I
P
A
R
-----
F
S
I
L
A
Y
N
P
V
F
E
I
K
F
E
N
G
V
L
Y
Q
N
G
Q
--------------------------------------------
V
I
D
R
D
P
L
D
F
L
Y
E
V
I
H
K
S
Q
------
H
H
S
E
L
P
F
G
G
G
A
I
G
F
V
G
Y
D
----
M
I
S
L
Y
E
E
I
G
QIPE
D
T
I
G
T
P
D
M
H
F
F
V
Y
-
E
S
Y
M
V
F
D
H
K
K
E
K
I
H
V
I
E
D
A
L
Y
S
ERS
Q
-
E
A
L
E
K
S
--------
L
N
Q
V
L
E
E
L
R
I
P
A
--
P
NEF-
E
D
L
-
D
L
S
P
L
D
F
K
P
H
I
A
P
H
K
F
E
G
M
V
E
T
A
R
D
L
I
R
N
G
D
M
F
Q
C
V
L
S
Q
R
F
S
A
E
V
T
--
G
N
P
F
D
F
Y
--
R
N
L
R
V
T
N
P
S
N
Y
L
Y
F
Y
D
F
G
------
D
Y
Q
----
I
I
G
A
S
P
E
S
L
V
S
V
K
-
N
-
G
-
I
V
T
T
N
P
I
A
---------------
E
E
----
D
K
A
L
A
T
D
L
--
L
-
S
D
E
K
E
T
A
E
H
R
M
L
V
D
L
G
R
N
D
I
G
R
I
S
E
T
T
S
V
Q
V
T
K
Y
M
E
V
E
L
F
R
Y
V
M
H
L
T
S
V
V
K
G
R
L
L
P
E
L
T
A
M
D
A
L
K
A
T
L
P
A
G
T
V
S
G
A
P
K
I
R
A
M
R
R
I
Y
E
L
E
T
E
K
R
G
V
Y
A
G
A
I
G
Y
L
S
A
T
G
D
M
D
L
A
I
A
I
R
T
M
I
L
K
N
Q
R
A
Y
V
Q
A
G
A
G
I
V
Y
D
S
I
A
Q
N
E
Y
Q
E
T
I
N
K
A
K
S
M
T
R
-------
38
HHSearch
69.62
22%
10
- C1 -
-
1I7Q
3
TRPE_SERMA
A:
[4-513]
---------
K
P
Q
L
T
L
L
K
V
Q
A
S
Y
R
--
G
D
P
T
T
L
F
H
Q
L
C
-
G
A-----
R
P
--
A
T
L
L
L
E
S
A
E
INDKQNL
Q
S
L
L
V
I
D
S
A
L
R
I
T
A
L
G
H
T
V
S
V
Q
A
L
T
A
N
G
P
A
L
L
P
L
L
D
E
A
LPPE
V
R
N
Q
A
R
PN
G
R
E
L
T
F
P
AIDAVQD
E
D
A
R
L
R
S
L
S
V
F
D
A
L
R
T
I
L
T
L
V
D
S
------
P
A
D
E
R
E
A
V
M
L
G
G
L
F
A
Y
D
----
L
V
A
G
F
E
N
L
P
ALR-
Q
D
Q
R
C
P
D
F
C
F
Y
L
A
-
E
T
L
L
V
L
D
H
Q
R
G
S
A
R
L
Q
A
S
V
F
S
E
Q
A
S
E
A
Q
R
L
Q
H
R
--------
L
E
Q
L
Q
A
E
L
Q
Q
P
P
Q-
P
I---
P
H
Q
-
K
L
E
N
M
Q
L
S
C
N
Q
S
D
E
E
Y
G
A
V
V
S
E
L
Q
E
A
I
R
Q
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
P
---
A
P
L
G
P
Y
--
Q
T
L
K
D
N
N
P
S
P
Y
M
F
F
M
Q
D
D
------
D
F
T
----
L
F
G
A
S
P
E
S
A
L
K
Y
D
-
A
G
N
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
A
DGSLD
L
D
L
----
D
S
R
I
E
L
E
M
--
R
-
T
D
H
K
E
L
A
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
Q
A
G
S
R
Y
V
A
D
L
T
K
V
D
R
Y
S
F
V
M
H
L
V
S
R
V
V
G
T
L
R
A
D
L
D
V
L
H
A
Y
Q
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
A
L
R
S
T
R
R
G
S
Y
G
G
R
V
G
Y
F
T
A
V
R
N
L
D
T
C
I
V
I
R
S
A
Y
V
E
D
G
H
R
T
V
Q
A
G
A
G
V
V
Q
D
S
I
P
E
R
E
A
D
E
T
R
N
K
A
R
A
V
L
R
A
I
A
T
A
H
-
1
PsiBlast_PDB
68.38
39%
22
- C1 -
-
1K0E
2
PABB_ECOLI
A:
[91-448]
------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
-
R
P
T
H
N
E
D
L
P
F
Q
G
G
A
L
G
L
F
G
Y
D
L
G
R
R
F
E
S
L
P
E
I
A
E
----
Q
D
I
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
--
T
V
S
L
L
S
H
N
D
V
-----
N
A
R
R
A
W
--------
L
E
S
Q
Q
F
S
P
-----------
Q
E
D
-
F
T
L
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
S
--
G
D
E
W
Q
A
F
--
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
E
------
Q
G
A
----
I
L
S
L
S
P
E
R
F
I
L
C
D
---
N
S
E
I
Q
T
R
P
I
K
G
T
L
P
R
---------------------------A
N
S
A
K
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
F
V
V
E
P
F
P
A
V
H
H
L
V
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
--------
21
PsiBlast_CBE
67.68
39%
18
- C1 -
-
1K0G
1
PABB_ECOLI
B:
[91-448]
------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
-
R
P
T
H
N
E
D
L
P
F
Q
G
G
A
L
G
L
F
G
Y
D
L
G
R
R
F
E
S
L
P
E
I
A
E
----
Q
D
I
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
--
T
V
S
L
L
S
H
N
D
V
-----
N
A
R
R
A
W
--------
L
E
S
Q
Q
F
S
P
-----------
Q
E
D
-
F
T
L
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
S
--
G
D
E
W
Q
A
F
--
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
E
------
Q
G
A
----
I
L
S
L
S
P
E
R
F
I
L
C
D
---
N
S
E
I
Q
T
R
P
I
K
G
--------------------------------------
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
-----------
L
V
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
--------
2
PsiBlast_PDB
66.97
39%
22
- C1 -
-
1K0G
1
PABB_ECOLI
A:
[91-448]
------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
-
R
P
T
H
N
E
D
L
P
F
Q
G
G
A
L
G
L
F
G
Y
D
L
G
R
R
F
E
S
L
P
E
I
A
E
----
Q
D
I
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
--
T
V
S
L
L
S
H
N
D
V
-----
N
A
R
R
A
W
--------
L
E
S
Q
Q
F
S
P
-----------
Q
E
D
-
F
T
L
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
S
--
G
D
E
W
Q
A
F
--
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
E
------
Q
G
A
----
I
L
S
L
S
P
E
R
F
I
L
C
D
---
N
S
E
I
Q
T
R
P
I
K
-------------------------------------
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
F
V
---------
L
V
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
--------
41
HHSearch
65.66
18%
20
- C1 -
-
3VEH
2
MBTI_MYCTU
B:
[19-450]
-----------------
S
I
P
M
P
A
G
V
N
-
P
A
D
L
A
A
E
L
A
-
A
V
VTESV
D
E
--
D
Y
L
L
Y
E
C
D
G
Q
------
W
V
-
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
--------------------------------------
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
-----------
L
E
T
D
Q
A
F
G
W
V
A
F
E
----
F
G
V
H
R
Y
G
L
Q
QR--
L
A
P
H
T
P
L
A
R
V
F
S
P
-
R
T
R
I
M
V
S
E
K
E
I
R
L
F
D
A
G
I
R
H
----------
R
E
A
--------
I
D
R
L
L
A
T
G
V
-----------
R
E
-
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
--
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
------
G
I
R
----
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
-
G
-
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
------
A
I
----
D
R
L
A
R
D
D
L
--
E
-
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
---
42
HHSearch
65.37
18%
19
- C1 -
-
3LOG
2
MBTI_MYCTU
D:
[19-450]
-----------------
S
I
P
M
P
A
G
V
N
-
P
A
D
L
A
A
E
L
A
-
A
VVTESV
D
E
--
D
Y
L
L
Y
E
C
D
G
Q------
W
V
-
L
A
A
G
V
Q
A
M
V
E
L
D
S
D
E
L
R
V
I
R
D
G
V
T
R
R
--------------------------------------
Q
Q
W
S
G
R
P
G
A
A
L
G
E
A
V
D
R
L
L
-----------
L
E
T
D
Q
A
F
G
W
V
A
F
E
----
F
G
V
H
R
Y
G
L
Q
QR--
L
A
P
H
T
P
L
A
R
V
F
S
P
-
R
T
R
I
M
V
S
E
K
E
IR
L
F
D
A
G
I
R
H
----------
R
E
A
--------
I
D
R
L
L
A
T
G
V
-----------
R
E
-
V
P
Q
S
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
A
--
I
D
F
P
L
T
Y
--
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
G
------
G
I
R
----
A
L
G
Y
S
P
E
L
V
T
A
V
R
A
D
-
G
-
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
P
------
A
I
----
D
R
L
A
R
D
D
L
--
E
-
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
T
P
Y
L
V
A
---
22
PsiBlast_CBE
64.50
39%
33
- C1 -
-
1K0E
1
PABB_ECOLI
B:
[91-448]
------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
-
R
P
T
H
N
E
D
L
P
F
Q
G
G
A
L
G
L
F
G
Y
D
L
G
R
R
F
E
S
L
P
E
I
A
E
----
Q
D
I
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
--
T
V
S
L
L
S
H
N
D
V
-----
N
A
R
R
A
W
--------
L
E
S
Q
Q
F
S
P
-----------
Q
E
D
-
F
T
L
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
S
--
G
D
E
W
Q
A
F
--
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
E
------
Q
G
A
----
I
L
S
L
S
P
E
R
F
I
L
C
D
---
N
S
E
I
Q
T
R
--------------------------------------
A
K
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
--------------
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
--------
31
Fugue
61.55
19%
-13
- C1 -
-
3HWO
1
ENTC_ECOLI
A:
[16-394]
-
M
A
T
L
A
P
N
R
F
F
F
M
S
---------------------------------------------------------
P
Y
R
S
F
T
T
S
G
C
F
A
R
F
D
E
P
A
V
N
G
D
--------------------------------------
S
P
D
S
P
F
Q
Q
K
L
A
A
L
F
A
D
A
K
A
Q
G
-
I
K
N
P
--------
V
M
V
G
A
I
P
F
D
------------------
P
R
Q
P
S
S
L
Y
I
------------
P
E
--
S
W
Q
S
F
S
R
Q
E
K
-----
Q
A
S
A
R
R
--------
F
T
R
S
Q
S
L
N
V
V
E
R
--
Q
----
A
I
P
------------
E
Q
T
T
F
E
Q
M
V
A
R
A
A
A
L
T
A
T
P
Q
V
D
K
V
V
L
S
R
L
I
D
I
T
T
D
--
A
A
I
-
D
S
G
--
V
L
L
E
R
L
I
A
Q
N
P
V
S
Y
N
F
H
V
------
P
L
A
DG
G
V
L
L
G
A
S
P
E
L
L
L
R
K
D
---
G
E
R
F
S
S
I
P
L
A
G
S
A
R
R
Q
P
D
E
------
V
L
----
D
R
E
A
G
N
R
L
--
L
-
A
S
E
K
D
R
H
E
H
E
L
V
T
Q
A
M
K
E
V
L
R
E
R
S
S
E
L
H
V
P
S
S
--
P
Q
L
I
T
T
P
T
L
W
H
L
A
T
P
F
E
G
K
A
N
S
Q
E
N
A
L
T
L
A
C
L
L
H
P
T
P
A
L
S
G
F
P
H
Q
A
A
T
Q
V
I
A
E
L
E
P
F
D
R
E
L
F
G
G
I
V
G
W
C
D
S
E
G
N
G
E
W
V
V
T
I
R
C
A
K
L
R
E
N
Q
V
R
L
F
A
G
A
G
I
V
P
A
S
S
P
L
G
E
W
R
E
T
G
V
K
L
S
T
M
L
N
V
F
G
L
H
--
3
PsiBlast_PDB
60.67
35%
6
- C1 -
-
4GRH
3
?
A:
[190-454]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
Q
R
F
T
D
G
V
R
R
V
I
E
Y
L
R
A
G
D
V
F
Q
V
N
L
S
R
R
W
N
A
Q
F
A
--
A
P
V
S
P
Q
A
L
Y
A
Q
L
R
R
A
N
P
A
P
F
A
G
L
F
S
A
H
------
G
R
H
----
V
V
S
S
S
P
E
R
L
V
S
V
H
-
A
--
G
H
A
Q
T
R
P
I
A
G
T
R
P
R
F
E
G
D
------
D
---------------------
E
R
A
E
H
V
M
L
I
D
L
E
R
N
D
L
G
R
I
C
L
P
G
T
V
V
V
D
E
L
M
T
V
E
S
Y
A
H
V
H
H
I
V
S
N
V
S
G
H
L
R
P
E
V
T
P
G
E
V
I
A
A
T
F
P
G
G
T
I
T
G
C
P
K
V
R
C
M
Q
I
I
S
E
L
E
Q
V
P
R
G
A
Y
T
G
A
F
G
W
L
N
R
D
G
D
L
D
L
N
I
L
I
R
T
A
E
V
D
G
H
E
V
S
F
R
T
G
A
G
I
V
V
D
S
D
P
D
K
E
L
D
E
T
R
A
K
A
R
G
L
L
R
A
L
G
----
9
PsiBlast_PDB
60.61
30%
-12
- C1 -
-
1I7S
1
TRPE_SERMA
A:
[240-512]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
Y
G
A
V
V
S
E
L
Q
E
A
I
R
Q
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
P
--
A
P
L
-
G
P
Y
--
Q
T
L
K
D
N
N
P
S
P
Y
M
F
F
M
Q
D
D
------
D
F
T
----
L
F
G
A
S
P
E
S
A
L
K
Y
D
-
A
G
N
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
A
------
D
G
SLD
L
D
L
D
S
R
I
E
L
E
M
R
-
T
D
H
K
E
L
A
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
Q
A
G
S
R
Y
V
A
D
L
T
K
V
D
R
Y
S
F
V
M
H
L
V
S
R
V
V
G
T
L
R
A
D
L
D
V
L
H
A
Y
Q
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
A
L
R
S
T
R
R
G
S
Y
G
G
R
V
G
Y
F
T
A
V
R
N
L
D
T
C
I
V
I
R
S
A
Y
V
E
D
G
H
R
T
V
Q
A
G
A
G
V
V
Q
D
S
I
P
E
R
E
A
D
E
T
R
N
K
A
R
A
V
L
R
A
I
A
T
A
--
44
HHSearch
60.41
17%
-10
- C1 -
-
2FN0
-
?
A:
[18-436]
---------------------
Q
W
L
P
T
-
I
S
G
V
L
R
Q
F
A
-
E
------
E
E
--
C
Y
V
Y
E
R
P
P
C
W
------
Y
L
G
K
G
C
Q
A
R
L
H
I
N
A
D
G
T
Q
A
T
F
I
D
D
A
G
-
E
Q
--------------------------------------
K
W
A
V
D
S
I
A
D
C
A
R
R
F
M
A
H
P
Q
-----------
V
K
G
R
R
V
Y
G
Q
V
G
F
N
----
F
A
A
H
A
R
G
I
A
F
---
N
A
G
E
W
P
L
L
T
L
T
V
P
-
R
E
E
L
I
F
E
K
G
N
--
V
T
V
Y
A
D
------------------------------------------------
A
P
L
A
V
D
T
A
L
N
G
E
A
Y
K
Q
Q
V
A
R
A
V
A
E
I
R
R
G
E
Y
V
K
V
I
V
S
R
A
I
P
L
P
S
R
--
I
D
M
P
A
T
L
--
L
Y
G
R
Q
A
N
T
P
V
R
S
F
M
F
R
Q
E
------
G
R
E
----
A
L
G
F
S
P
E
L
V
M
S
V
T
-
G
-
N
-
K
V
V
T
E
P
L
A
G
T
R
D
R
M
G
N
P
------
E
H
----
N
K
A
K
E
A
E
L
--
L
-
H
D
S
K
E
V
L
E
H
I
L
S
V
K
E
A
I
A
E
L
E
A
V
C
L
P
G
S
V
V
V
E
D
L
M
S
V
R
Q
R
G
S
V
Q
H
L
G
S
G
V
S
G
Q
L
A
E
N
K
D
A
W
D
A
F
T
V
L
F
P
S
I
T
A
S
G
I
P
K
N
A
A
L
N
A
I
M
Q
I
E
K
T
P
R
E
L
Y
S
G
A
I
L
L
L
D
D
-
T
R
F
D
A
A
L
V
L
R
S
V
F
Q
D
S
Q
R
C
W
I
Q
A
G
A
G
I
I
A
Q
S
T
P
E
R
E
L
T
E
T
R
E
K
L
A
S
I
A
P
Y
L
M
----