@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VV48: (2017-12-22 )
MKFSKILVANRGEIAVRVMQTAKAMGYQTVAVYSDADRNARHVQEADEAVYIGASKVSESYLSIAKIIEACKKTGADAVHPGYGFLSENTDFAQACIDNQITFIGPTASAIELMGSKRLSKIAMIEAGVPCVPGYEGDRQDLEYLATQAEQIGFPIMVKASAGGGGRGMRLVQQASELFEALQTARSEAENAFGSGELILEKAVIAPRHVEIQVFGDTHGNYVYLFERDCSIQRRHQKVVEEAPCPVMTPELRQKMGEAAVAAAKTCAYVGAGTVEFLLDASGAFYFLEMNTRLQVEHPVTELITGLDLVEWQLRVANGEQLPLKQQELTLNGHAIEVRLYAEDPRQDFLPQTGKILRWKPAALPNVRIDHGMLATDEVSPFYDPMVAKVIAYGKTREDAIRLLARAVDDSVLLGVNSNKQFLVNLLRHPVVVAGDTNTAFIQQHFKNDPSLHYQVLSLETLAIAAALFSQSKGPAVWQTGLGVPLPLKLQTADQQIQLQLSSVNNTFTVQFCEQVVCIDVLEKTPEQLVYLIDGVRRRVQYVLDDDQLYLDRDNGNVLIRNMTYAAPEATDVAGDGKIRAPMDGAVVNILVNEGDQVVKGQTLLILEAMKIQQQIKSDVDGVVDEILGQQGQQVKKRQMLFSIQI
Atome Classification :
(58 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130......-.140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.-.......290.......300.......310.......320.......330.......340.......350.......360..-.-..--...370.......380.......390.......400........410.......420.......430.......440....-.------.--.-450.-----------......460.....-..--------470.----------....----..-480--------........490--.......500.......510...---...-.-520----.-....-..-------.530-......-----------.540.......550.......560.....----------..---570-----.........580.......590.......600.......610.......620.......630.......640....--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MK
F
S
K
I
L
V
ANRG
E
I
A
V
R
V
M
Q
T
A
K
AMG
Y
Q
T
V
A
V
Y
SDADRN
A
R
H
V
Q
EAD
E
A
V
Y
I
G
A
S
K
V
S
E
S
Y
L
S
I
A
K
I
I
E
A
C
K
KTGADAVHPGYGFLSEN
T
D
F
A
Q
A
C
IDN
Q
I
T
F
IGP
T
A
S
A
I
E
L
M
G
S
K
R
L
S
K
I
A
M
IEAGVPCVPGYEG
D
-
R
Q
D
L
E
Y
L
A
T
Q
A
E
QIG
F
P
I
M
V
K
A
SAGGGG
R
G
M
R
L
V
Q
Q
A
S
E
L
F
E
A
L
Q
T
A
R
S
E
A
ENAFGSG
E
L
I
L
E
KAVIAP
R
H
V
E
I
Q
V
F
GDTHG
N
Y
V
Y
L
FERDC
S
I
Q
R
R
H
Q
K
V
V
E
EAPCPVM
T
P
E
L
R
Q
K
M
G
E
A
A
V
A
A
A
K
T
C
A
Y
VGA
G
T
V
E
F
L
LDA-S-G
A
F
Y
F
L
EMN
T
R
L
Q
V
EH
P
V
T
E
L
I
TGL
D
L
V
E
W
Q
L
R
VANGEQLPLKQ
Q
E
L
T
LNG
H
A
I
E
V
R
L
Y
AED
P
R
Q
DFLPQTG
K
I
L
R
WK-PAA-L-PN--
V
R
IDHGMLATDEVSP
F
Y
D
P
M
V
A
K
V
I
AYGK
T
R
E
D
A
I
-
R
L
L
A
R
AVDD
S
V
L
L
G
VNS
N
K
Q
F
L
V
N
L
LRH
P
V
V
V
AGDT
N
T
A
F
I
Q
Q
H
F-K------N--D-P
S
L
H
-----------
Y
Q
V
L
S
L
E
T
L
A
I
A
A
A
-
L
F
--------SQSK----------GP
A
V
----
W
Q-TG---------LGVPL
P
L
K
L
QT--AD
Q
Q
I
Q
L
Q
L
SSVN
N
T
F
T
V
Q
F
C
E
Q
---
V
V
C
-
I
-
D
-
V
----
L
-EK
T
P
-
E
Q
-------
L
V
Y
L
-
I
D
G
V
R
R
-----------
R
V
Q
Y
V
LDDD
Q
L
Y
L
DRDNG
N
V
L
I
RNMTYAA----------PE---A-------TDVAGDG
K
I
RAPMD
G
A
V
V
N
I
L
VNEGD
Q
V
VKG
Q
T
L
L
I
L
E
A
M
K
I
Q
Q
Q
I
K
S
D
V
D
G
V
V
D
E
I
L
G
QQ
G
Q
Q
V
K
K
R
Q
M
L
F
S
IQI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.82
48%
-49
- C3 -
-
3U9S
1
?
A:
[30-663]
-----
R
L
L
V
A
N
R
G
E
I
A
C
R
V
M
R
S
A
R
A
L
G
I
G
S
V
A
V
H
S
D
I
D
R
H
A
R
H
V
A
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A
D
I
A
V
D
L
G
G
A
K
P
A
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Y
L
R
G
D
R
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I
A
A
A
L
A
S
G
A
Q
A
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P
G
Y
G
F
L
S
E
N
A
D
F
A
R
A
C
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E
A
G
L
L
F
L
G
P
P
A
A
A
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A
M
G
S
K
S
A
A
K
A
L
M
E
E
A
G
V
P
L
V
P
G
Y
H
G
E
-
A
Q
D
L
E
T
F
R
R
E
A
G
R
I
G
Y
P
V
L
L
K
A
A
A
------
M
K
V
V
E
R
E
A
E
L
A
E
A
L
S
S
A
Q
R
--------
A
R
M
L
V
E
K
Y
L
L
K
P
R
H
V
E
I
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V
F
A
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L
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N
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R
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V
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A
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A
A
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A
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Y
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V
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F
L
L
D
E
-
R
-
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F
F
F
M
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M
N
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L
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H
P
V
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A
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G
L
D
L
V
A
W
Q
I
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A
R
G
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A
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L
T
Q
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Q
V
P
L
N
G
H
A
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V
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L
Y
A
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D
P
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L
P
A
S
G
R
L
M
L
Y
R
-
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A
A
-
A
G
P
G
--
R
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V
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M
L
A
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L
I
A
W
G
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T
R
E
E
A
R
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R
L
L
A
M
L
A
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T
S
V
-
G
G
L
R
T
N
L
A
F
L
R
R
I
L
G
H
P
A
F
A
A
A
E
L
D
T
G
F
I
A
R
H
--
Q
------
D
--
D
-
L
L
P
A
-----------
P
Q
A
L
P
E
H
F
W
Q
A
A
A
E
-
A
W
--------
L
Q
S
E
PGHRRDDDPH
S
P
W
S
RNDG
W
R
-
S
A
---------
L
A
R
E
S
D
L
M
L
R
C
--
R
D
E
R
-----------------------
R
C
-
V
-
R
-
L
----
R
-
H
A
S
P
-
S
Q
Y
R
L
D
GD
D
L
V
S
R
-
V
D
G
V
T
R
-----------
R
S
A
A
L
R
R
G
R
Q
L
F
L
E
W
E
G
E
L
L
A
I
E
A
V
D
--------------------------------
G
G
L
S
A
P
M
N
G
S
I
V
R
V
L
V
E
P
G
Q
T
V
E
A
G
A
T
L
V
V
L
E
A
M
K
M
E
H
S
I
R
A
P
H
A
G
V
V
K
A
L
Y
C
S
E
G
E
L
V
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.22
48%
-56
- C3 -
-
3U9T
-
?
A:
[51-639]
-----
R
L
L
V
A
N
R
G
E
I
A
C
R
V
M
R
S
A
R
A
L
G
I
G
S
V
A
V
H
S
D
I
D
R
H
A
R
H
V
A
E
A
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I
A
V
D
L
G
G
A
K
P
A
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Y
L
R
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R
I
I
A
A
A
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A
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G
A
Q
A
I
H
P
G
Y
G
F
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E
N
A
D
F
A
R
A
C
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E
A
G
L
L
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L
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P
P
A
A
A
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D
A
M
G
S
K
S
A
A
K
A
L
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E
A
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P
L
V
P
G
Y
H
G
E
-
A
Q
D
L
E
T
F
R
R
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A
G
R
I
G
Y
P
V
L
L
K
A
A
A
------
M
K
V
V
E
R
E
A
E
L
A
E
A
L
S
S
A
Q
R
--------
A
R
M
L
V
E
K
Y
L
L
K
P
R
H
V
E
I
Q
V
F
A
D
R
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G
H
C
L
Y
L
N
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A
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A
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A
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L
L
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R
-
G
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F
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F
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N
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A
I
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A
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A
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R
L
M
L
Y
R
-
E
A
A
-
A
G
P
G
--
R
R
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D
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G
D
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Y
D
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L
A
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L
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G
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T
R
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A
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R
L
L
A
M
L
A
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-
G
G
L
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N
L
A
F
L
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L
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P
A
F
A
A
A
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L
D
T
G
F
I
A
R
H
--
Q
------
D
--
D
-
L
L
P
A
-----------
P
Q
A
L
P
E
H
F
W
Q
A
A
A
E
-
A
W
--------
L
Q
S
E
PGHRRDDDPH
S
P
W
S
RNDG
W
R
-
S
A
---------
L
A
R
E
S
D
L
M
L
R
C
--
R
D
E
R
-----------------------
R
C
-
V
-
R
-
L
----
R
-
H
A
S
P
-
S
Q
Y
R
L
D
GD
D
L
V
S
R
-
V
D
G
V
T
R
-----------
R
S
A
A
L
R
R
G
R
Q
L
F
L
E
W
E
G
E
L
L
A
I
E
A
V
D
P
I
A
----------
E
A
---
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
73.98
48%
-52
- C3 -
-
3U9S
1
?
A:
[26-671]
-
R
S
I
Q
R
L
L
V
A
N
R
G
E
I
A
C
R
V
M
R
S
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R
A
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A
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A
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A
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A
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--------
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------
D
--
L
-
L
P
A
P
-----------
Q
A
L
--
P
E
H
F
W
Q
A
A
A
E
A
W
L
Q
S
E
PGHR
R
D
D
D
----------
P
H
S
P
----
W
S
-
R
N
---------
D
G
W
R
S
---
A
L
A
--
R
E
S
D
L
M
L
R
C
R
D
E
R
R
C
V
R
L
R
H
A
S
P
SQ-
Y
R
--------------
L
D
G
-
D
D
-------
L
V
S
R
-
V
D
G
V
T
R
-----------
R
S
A
A
L
R
R
G
R
Q
L
F
L
E
W
E
G
-
E
L
--
L
A
I
E
A
V
D
-----------------------------
G
G
L
S
A
P
M
N
G
S
I
V
R
V
L
V
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Q
T
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A
T
L
V
V
L
E
A
M
K
M
E
H
S
I
R
A
P
H
A
G
V
V
K
A
L
Y
C
S
E
G
E
L
V
E
E
G
T
P
L
V
E
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
73.28
42%
-65
- C3 -
-
3N6R
1
?
G:
[2-681]
---
F
N
K
I
L
I
A
N
R
G
E
I
A
C
R
V
I
K
T
A
R
K
M
G
I
S
T
V
A
I
Y
S
D
A
D
K
Q
A
L
H
V
Q
M
A
D
E
A
V
H
I
G
P
P
P
A
N
Q
S
Y
I
V
I
D
K
V
M
A
A
I
R
A
T
G
A
Q
A
V
H
P
G
Y
G
F
L
S
E
N
S
K
F
A
E
A
L
E
A
E
G
V
I
F
V
G
P
P
K
G
A
I
E
A
M
G
D
K
I
T
S
K
K
I
A
Q
E
A
N
V
S
T
V
P
G
Y
M
G
L
-
I
E
D
A
D
E
A
V
K
I
S
N
Q
I
G
Y
P
V
M
I
K
A
S
A
------
M
R
I
A
W
N
D
Q
E
A
R
E
G
F
Q
S
S
K
N
--------
D
R
I
F
I
E
K
F
V
T
Q
P
R
H
I
E
I
Q
V
L
C
D
S
H
G
N
G
I
Y
L
G
E
R
E
C
S
I
Q
R
R
N
Q
K
V
V
E
E
A
P
S
P
F
L
D
E
A
T
R
R
A
M
G
E
Q
A
V
A
L
A
K
A
V
G
Y
A
S
A
G
T
V
E
F
I
V
D
G
-
Q
-
K
N
F
Y
F
L
E
M
N
T
R
L
Q
V
E
H
P
V
T
E
L
I
T
G
V
D
L
V
E
Q
M
I
R
V
A
A
G
E
P
L
S
I
T
Q
G
D
V
K
L
T
G
W
A
I
E
N
R
L
Y
A
E
D
P
Y
R
G
F
L
P
S
I
G
R
L
T
R
Y
R
-
P
P
A
-
E
-
A
A
--
V
R
N
D
T
G
V
Y
E
G
G
E
I
S
M
Y
Y
D
P
M
I
A
K
L
C
T
W
A
P
T
R
A
A
A
I
-
E
A
M
R
I
A
L
D
S
F
E
V
E
G
I
G
H
N
L
P
F
L
S
A
V
M
D
H
P
K
F
I
S
G
D
M
T
T
A
F
I
A
E
E
Y
-
P
------
E
--
G
-
F
E
G
V
-----------
N
L
P
E
T
D
L
R
R
V
A
A
A
A
-
A
A
---------
M
H
R
----------
V
A
E
I
----
R
R
T
R
V
---------
S
G
R
M
D
---
N
H
E
RR
V
G
T
E
W
V
V
T
L
Q
G
A
D
F
P
V
T
I
A
A
D
H
D
GST
V
S
F
D
D
G
S
S
M
RVTS
D
W
T
P
G
D
-
Q
L
-------
A
N
L
M
-
V
D
G
A
P
L
-----------
V
L
K
V
G
K
I
S
G
G
F
R
I
R
T
R
G
-
A
D
--
L
K
V
H
V
R
T
PRQAELARLM
P
E
---
K
-------
L
P
P
D
T
S
K
M
L
L
C
P
M
P
G
L
I
V
K
V
D
V
E
V
G
Q
E
V
Q
E
G
Q
A
L
C
T
I
E
A
M
K
M
E
N
I
L
R
A
E
K
K
G
V
V
A
K
I
N
A
S
A
G
N
S
L
A
V
D
D
V
I
M
E
F
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
72.48
41%
-61
- C3 -
-
3N6R
1
?
K:
[2-671]
---
F
N
K
I
L
I
A
N
R
G
E
I
A
C
R
V
I
K
T
A
R
K
M
G
I
S
T
V
A
I
Y
S
D
A
D
K
Q
A
L
H
V
Q
M
A
D
E
A
V
H
I
G
P
P
P
A
N
Q
S
Y
I
V
I
D
K
V
M
A
A
I
R
A
T
G
A
Q
A
V
H
P
G
Y
G
F
L
S
E
N
S
K
F
A
E
A
L
E
A
E
G
V
I
F
V
G
P
P
K
G
A
I
E
A
M
G
D
K
I
T
S
K
K
I
A
Q
E
A
N
V
S
T
V
P
G
Y
M
G
L
-
I
E
D
A
D
E
A
V
K
I
S
N
Q
I
G
Y
P
V
M
I
K
A
S
A
------
M
R
I
A
W
N
D
Q
E
A
R
E
G
F
Q
S
S
K
N
--------
D
R
I
F
I
E
K
F
V
T
Q
P
R
H
I
E
I
Q
V
L
C
D
S
H
G
N
G
I
Y
L
G
E
R
E
C
S
I
Q
R
R
N
Q
K
V
V
E
E
A
P
S
P
F
L
D
E
A
T
R
R
A
M
G
E
Q
A
V
A
L
A
K
A
V
G
Y
A
S
A
G
T
V
E
F
I
V
D
G
-
Q
-
K
N
F
Y
F
L
E
M
N
T
R
L
Q
V
E
H
P
V
T
E
L
I
T
G
V
D
L
V
E
Q
M
I
R
V
A
A
G
E
P
L
S
I
T
Q
G
D
V
K
L
T
G
W
A
I
E
N
R
L
Y
A
E
D
P
Y
R
G
F
L
P
S
I
G
R
L
T
R
Y
R
-
P
P
A
E----AA
V
R
N
D
T
G
V
Y
E
G
G
E
I
S
M
Y
Y
D
P
M
I
A
K
L
C
T
W
A
P
T
R
A
A
A
I
-
E
A
M
R
I
A
L
D
S
F
E
V
E
G
I
G
H
N
L
P
F
L
S
A
V
M
D
H
P
K
F
I
S
G
D
M
T
T
A
F
I
A
E
E
Y
-
P
EGFEGV
N
--
L
-
P
E
T
D
LRRVAAAAAAM
H
R
V
A
E
I
R
R
T
R
V
S
G
R
-
M
D
--------
N
H
E
R
----------------------
R
---------
V
G
T
E
W
V
V
T
L
Q
G
--
A
D
--
F
P
V
T
I
A
A
D
H
D
G
S
T
V
S
F
D
D
G
---
S
S
M
-
R
-
V
-
T
----
S
-
D
W
T
P
G
D
Q
-------
L
A
N
L
M
V
D
G
A
P
L
VLKVGKISGGF
R
I
R
T
R
G
A
D
L
K
V
H
V
R
T
P
R
Q
A
E
L
A
R
L
M
P
E
K
L
----------
P
P
---
D
-------
T
----
S
K
M
L
L
C
P
M
P
G
L
I
V
K
V
D
V
E
V
G
Q
E
V
Q
E
G
Q
A
L
C
T
I
E
A
M
K
M
E
N
I
L
R
A
E
K
K
G
V
V
A
K
I
N
A
S
A
G
N
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
72.28
41%
-60
- C3 -
-
3N6R
1
?
G:
[2-671]
---
F
N
K
I
L
I
A
N
R
G
E
I
A
C
R
V
I
K
T
A
R
K
M
G
I
S
T
V
A
I
Y
S
D
A
D
K
Q
A
L
H
V
Q
M
A
D
E
A
V
H
I
G
P
P
P
A
N
Q
S
Y
I
V
I
D
K
V
M
A
A
I
R
A
T
G
A
Q
A
V
H
P
G
Y
G
F
L
S
E
N
S
K
F
A
E
A
L
E
A
E
G
V
I
F
V
G
P
P
K
G
A
I
E
A
M
G
D
K
I
T
S
K
K
I
A
Q
E
A
N
V
S
T
V
P
G
Y
M
G
L
-
I
E
D
A
D
E
A
V
K
I
S
N
Q
I
G
Y
P
V
M
I
K
A
S
A
------
M
R
I
A
W
N
D
Q
E
A
R
E
G
F
Q
S
S
K
N
--------
D
R
I
F
I
E
K
F
V
T
Q
P
R
H
I
E
I
Q
V
L
C
D
S
H
G
N
G
I
Y
L
G
E
R
E
C
S
I
Q
R
R
N
Q
K
V
V
E
E
A
P
S
P
F
L
D
E
A
T
R
R
A
M
G
E
Q
A
V
A
L
A
K
A
V
G
Y
A
S
A
G
T
V
E
F
I
V
D
G
-
Q
-
K
N
F
Y
F
L
E
M
N
T
R
L
Q
V
E
H
P
V
T
E
L
I
T
G
V
D
L
V
E
Q
M
I
R
V
A
A
G
E
P
L
S
I
T
Q
G
D
V
K
L
T
G
W
A
I
E
N
R
L
Y
A
E
D
P
Y
R
G
F
L
P
S
I
G
R
L
T
R
Y
R
-
P
P
A
E----AA
V
R
N
D
T
G
V
Y
E
G
G
E
I
S
M
Y
Y
D
P
M
I
A
K
L
C
T
W
A
P
T
R
A
A
A
I
-
E
A
M
R
I
A
L
D
S
F
E
V
E
G
I
G
H
N
L
P
F
L
S
A
V
M
D
H
P
K
F
I
S
G
D
M
T
T
A
F
I
A
E
E
Y
-
P
EGFEGV
N
--
L
-
P
E
T
D
LRRVAAAAAAM
H
R
V
A
E
I
R
R
T
R
V
S
G
R
-
M
D
--------
N
H
E
R
----------------------
R
---------
V
G
T
E
W
V
V
T
L
Q
G
--
A
D
--
F
P
V
T
I
A
A
D
H
D
G
S
T
V
S
F
D
D
G
---
S
S
M
-
R
-
V
-
T
----
S
-
D
W
T
P
G
D
Q
-------
L
A
N
L
M
V
D
G
A
P
L
VLKVGKISGGF
R
I
R
T
R
G
A
D
L
K
V
H
V
R
T
P
R
Q
A
E
L
A
R
L
M
P
E
K
L
----------
P
P
---
D
-------
T
----
S
K
M
L
L
C
P
M
P
G
L
I
V
K
V
D
V
E
V
G
Q
E
V
Q
E
G
Q
A
L
C
T
I
E
A
M
K
M
E
N
I
L
R
A
E
K
K
G
V
V
A
K
I
N
A
S
A
G
N
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
72.25
48%
-60
- C3 -
-
3U9T
-
?
A:
[47-639]
-
R
S
I
Q
R
L
L
V
A
N
R
G
E
I
A
C
R
V
M
R
S
A
R
A
L
G
I
G
S
V
A
V
H
S
D
I
D
R
H
A
R
H
V
A
E
A
D
I
A
V
D
L
G
G
A
K
P
A
D
S
Y
L
R
G
D
R
I
I
A
A
A
L
A
S
G
A
Q
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
R
A
C
E
E
A
G
L
L
F
L
G
P
P
A
A
A
I
D
A
M
G
S
K
S
A
A
K
A
L
M
E
E
A
G
V
P
L
V
P
G
Y
H
G
E
-
A
Q
D
L
E
T
F
R
R
E
A
G
R
I
G
Y
P
V
L
L
K
A
A
A
------
M
K
V
V
E
R
E
A
E
L
A
E
A
L
S
S
A
Q
R
--------
A
R
M
L
V
E
K
Y
L
L
K
P
R
H
V
E
I
Q
V
F
A
D
R
H
G
H
C
L
Y
L
N
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
L
G
A
E
L
R
R
A
M
G
E
A
A
V
R
A
A
Q
A
I
G
Y
V
G
A
G
T
V
E
F
L
L
D
E
-
R
-
G
Q
F
F
F
M
E
M
N
T
R
L
Q
V
E
H
P
V
T
E
A
I
T
G
L
D
L
V
A
W
Q
I
R
V
A
R
G
E
A
L
P
L
T
Q
E
Q
V
P
L
N
G
H
A
I
E
V
R
L
Y
A
E
D
P
E
G
D
F
L
P
A
S
G
R
L
M
L
Y
R
-
E
A
A
A
G
-
P
G
--
R
R
V
D
S
G
V
R
E
G
D
E
V
S
P
F
Y
D
P
M
L
A
K
L
I
A
W
G
E
T
R
E
E
A
R
-
Q
R
L
L
A
M
L
A
E
T
S
V
G
G
L
R
T
N
L
A
F
L
R
R
I
L
G
H
P
A
F
A
A
A
E
L
D
T
G
F
I
A
R
H
Q
-
D
------
D
--
L
-
L
P
A
P
-----------
Q
A
L
--
P
E
H
F
W
Q
A
A
A
E
A
W
L
Q
S
E
PGHR
R
D
D
D
----------
P
H
S
P
----
W
S
-
R
N
---------
D
G
W
R
S
---
A
L
A
--
R
E
S
D
L
M
L
R
C
R
D
E
R
R
C
V
R
L
R
H
A
S
P
SQ-
Y
R
--------------
L
D
G
-
D
D
-------
L
V
S
R
-
V
D
G
V
T
R
-----------
R
S
A
A
L
R
R
G
R
Q
L
F
L
E
W
E
G
-
E
L
--
L
A
I
E
A
V
D
----------
P
I
AEA
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
72.14
41%
-59
- C3 -
-
3N6R
1
?
I:
[2-671]
---
F
N
K
I
L
I
A
N
R
G
E
I
A
C
R
V
I
K
T
A
R
K
M
G
I
S
T
V
A
I
Y
S
D
A
D
K
Q
A
L
H
V
Q
M
A
D
E
A
V
H
I
G
P
P
P
A
N
Q
S
Y
I
V
I
D
K
V
M
A
A
I
R
A
T
G
A
Q
A
V
H
P
G
Y
G
F
L
S
E
N
S
K
F
A
E
A
L
E
A
E
G
V
I
F
V
G
P
P
K
G
A
I
E
A
M
G
D
K
I
T
S
K
K
I
A
Q
E
A
N
V
S
T
V
P
G
Y
M
G
L
-
I
E
D
A
D
E
A
V
K
I
S
N
Q
I
G
Y
P
V
M
I
K
A
S
A
------
M
R
I
A
W
N
D
Q
E
A
R
E
G
F
Q
S
S
K
N
--------
D
R
I
F
I
E
K
F
V
T
Q
P
R
H
I
E
I
Q
V
L
C
D
S
H
G
N
G
I
Y
L
G
E
R
E
C
S
I
Q
R
R
N
Q
K
V
V
E
E
A
P
S
P
F
L
D
E
A
T
R
R
A
M
G
E
Q
A
V
A
L
A
K
A
V
G
Y
A
S
A
G
T
V
E
F
I
V
D
G
-
Q
-
K
N
F
Y
F
L
E
M
N
T
R
L
Q
V
E
H
P
V
T
E
L
I
T
G
V
D
L
V
E
Q
M
I
R
V
A
A
G
E
P
L
S
I
T
Q
G
D
V
K
L
T
G
W
A
I
E
N
R
L
Y
A
E
D
P
Y
R
G
F
L
P
S
I
G
R
L
T
R
Y
R
-
P
P
A
E----AA
V
R
N
D
T
G
V
Y
E
G
G
E
I
S
M
Y
Y
D
P
M
I
A
K
L
C
T
W
A
P
T
R
A
A
A
I
-
E
A
M
R
I
A
L
D
S
F
E
V
E
G
I
G
H
N
L
P
F
L
S
A
V
M
D
H
P
K
F
I
S
G
D
M
T
T
A
F
I
A
E
E
Y
-
P
EGFEGV
N
--
L
-
P
E
T
D
LRRVAAAAAAM
H
R
V
A
E
I
R
R
T
R
V
S
G
R
-
M
D
--------
N
H
E
R
----------------------
R
---------
V
G
T
E
W
V
V
T
L
Q
G
--
A
D
--
F
P
V
T
I
A
A
D
H
D
G
S
T
V
S
F
D
D
G
---
S
S
M
-
R
-
V
-
T
----
S
-
D
W
T
P
G
D
Q
-------
L
A
N
L
M
V
D
G
A
P
L
VLKVGKISGGF
R
I
R
T
R
G
A
D
L
K
V
H
V
R
T
P
R
Q
A
E
L
A
R
L
M
P
E
K
L
----------
P
P
---
D
-------
T
----
S
K
M
L
L
C
P
M
P
G
L
I
V
K
V
D
V
E
V
G
Q
E
V
Q
E
G
Q
A
L
C
T
I
E
A
M
K
M
E
N
I
L
R
A
E
K
K
G
V
V
A
K
I
N
A
S
A
G
N
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
HHSearch
69.88
44%
-91
- C3 -
-
3OUU
4
?
A:
[4-446]
-
M
E
I
K
S
I
L
I
A
N
R
G
E
I
A
L
R
A
L
R
T
I
K
E
M
G
K
K
A
I
C
V
Y
S
E
A
D
K
D
A
L
Y
L
K
Y
A
D
A
S
I
C
I
G
K
A
R
S
S
E
S
Y
L
N
I
P
A
I
I
A
A
A
E
I
A
E
A
D
A
I
F
P
G
Y
G
F
L
S
E
N
Q
N
F
V
E
I
C
A
K
H
N
I
K
F
I
G
P
S
V
E
A
M
N
L
M
S
D
K
S
K
A
K
Q
V
M
Q
R
A
G
V
P
V
I
P
G
S
D
G
A
-
L
A
G
A
E
A
A
K
K
L
A
K
E
I
G
Y
P
V
I
L
K
A
A
A
G
G
G
G
R
G
M
R
V
V
E
N
E
K
D
L
E
K
A
Y
W
S
A
E
S
E
A
M
T
A
F
G
D
G
T
M
Y
M
E
K
Y
I
Q
N
P
R
H
I
E
V
Q
V
I
G
D
S
F
G
N
V
I
H
V
G
E
R
D
C
S
M
Q
R
R
H
Q
K
L
I
E
E
S
P
A
I
L
L
D
E
K
T
R
T
R
L
H
E
T
A
I
K
A
A
K
A
I
G
Y
E
G
A
G
T
F
E
F
L
V
D
K
-
N
-
L
D
F
Y
F
I
E
M
N
T
R
L
Q
V
E
H
C
V
S
E
M
V
S
G
I
D
I
I
E
Q
M
I
K
V
A
E
G
Y
A
L
P
S
Q
E
S
-
I
K
L
N
G
H
S
I
E
C
R
I
T
A
E
D
S
-
K
T
F
L
P
S
P
G
K
I
T
K
Y
I
-
P
P
A
-
G
-
R
N
--
V
R
M
E
S
H
C
Y
Q
D
Y
S
V
P
A
Y
Y
D
S
M
I
G
K
L
V
V
W
A
E
D
R
N
K
A
I
-
A
K
M
K
V
A
L
D
E
L
L
I
S
G
I
K
T
T
K
D
F
H
L
S
M
M
E
N
P
D
F
I
N
N
N
Y
D
T
N
Y
L
A
R
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
HHSearch
69.67
44%
-93
- C3 -
-
3OUZ
13
?
A:
[4-446]
-
M
E
I
K
S
I
L
I
A
N
R
G
E
I
A
L
R
A
L
R
T
I
K
E
M
G
K
K
A
I
C
V
Y
S
E
A
D
K
D
A
L
Y
L
K
Y
A
D
A
S
I
C
I
G
K
A
R
S
S
E
S
Y
L
N
I
P
A
I
I
A
A
A
E
I
A
E
A
D
A
I
F
P
G
Y
G
F
L
S
E
N
Q
N
F
V
E
I
C
A
K
H
N
I
K
F
I
G
P
S
V
E
A
M
N
L
M
S
D
K
S
K
A
K
Q
V
M
Q
R
A
G
V
P
V
I
P
G
S
D
G
A
-
L
A
G
A
E
A
A
K
K
L
A
K
E
I
G
Y
P
V
I
L
K
A
A
A
G
G
G
G
R
G
M
R
V
V
E
N
E
K
D
L
E
K
A
Y
W
S
A
E
S
E
A
M
T
A
F
G
D
G
T
M
Y
M
E
K
Y
I
Q
N
P
R
H
I
E
V
Q
V
I
G
D
S
F
G
N
V
I
H
V
G
E
R
D
C
S
M
Q
R
R
H
Q
K
L
I
E
E
S
P
A
I
L
L
D
E
K
T
R
T
R
L
H
E
T
A
I
K
A
A
K
A
I
G
Y
E
G
A
G
T
F
E
F
L
V
D
K
-
N
-
L
D
F
Y
F
I
E
M
N
T
R
L
Q
V
E
H
C
V
S
E
M
V
S
G
I
D
I
I
E
Q
M
I
K
V
A
E
G
Y
A
L
P
S
Q
E
S
-
I
K
L
N
G
H
S
I
E
C
R
I
T
A
E
D
S
-
K
T
F
L
P
S
P
G
K
I
T
K
Y
I
-
P
P
A
-
G
-
R
N
--
V
R
M
E
S
H
C
Y
Q
D
Y
S
V
P
A
Y
Y
D
S
M
I
G
K
L
V
V
W
A
E
D
R
N
K
A
I
-
A
K
M
K
V
A
L
D
E
L
L
I
S
G
I
K
T
T
K
D
F
H
L
S
M
M
E
N
P
D
F
I
N
N
N
Y
D
T
N
Y
L
A
R
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
69.32
41%
-58
- C3 -
-
3N6R
1
?
C:
[2-671]
---
F
N
K
I
L
I
A
N
R
G
E
I
A
C
R
V
I
K
T
A
R
K
M
G
I
S
T
V
A
I
Y
S
D
A
D
K
Q
A
L
H
V
Q
M
A
D
E
A
V
H
I
G
P
P
P
A
N
Q
S
Y
I
V
I
D
K
V
M
A
A
I
R
A
T
G
A
Q
A
V
H
P
G
Y
G
F
L
S
E
N
S
K
F
A
E
A
L
E
A
E
G
V
I
F
V
G
P
P
K
G
A
I
E
A
M
G
D
K
I
T
S
K
K
I
A
Q
E
A
N
V
S
T
V
P
G
----------------------------------------------------------------------
V
T
Q
P
R
H
I
E
I
Q
V
L
C
D
S
H
G
N
G
I
Y
L
G
E
R
E
C
S
I
Q
R
R
N
Q
K
V
V
E
E
A
P
S
P
F
L
D
E
A
T
R
R
A
M
G
E
Q
A
V
A
L
A
K
A
V
G
Y
A
S
A
G
T
V
E
F
I
V
D
G
-
Q
-
K
N
F
Y
F
L
E
M
N
T
R
L
Q
V
E
H
P
V
T
E
L
I
T
G
V
D
L
V
E
Q
M
I
R
V
A
A
G
E
P
L
S
I
T
Q
G
D
V
K
L
T
G
W
A
I
E
N
R
L
Y
A
E
D
P
Y
R
G
F
L
P
S
I
G
R
L
T
R
Y
R
-
P
P
A
E
----
A
A
V
R
N
D
T
G
V
Y
E
G
G
E
I
S
M
Y
Y
D
P
M
I
A
K
L
C
T
W
A
P
T
R
A
A
A
I
-
E
A
M
R
I
A
L
D
S
F
E
V
E
G
I
G
H
N
L
P
F
L
S
A
V
M
D
H
P
K
F
I
S
G
D
M
T
T
A
F
I
A
E
E
Y
-
P
E
G
FE
G
V
N
--
L
-
P
E
T
D
L
R
R
V
A
A
A
A
A
A
M
H
R
V
A
E
I
R
R
T
R
V
S
G
R
-
M
D
--------
N
H
E
R
----------------------
R
---------
V
G
T
E
W
V
V
T
L
Q
G
--
A
D
--
F
P
V
T
I
A
A
D
H
D
G
S
T
V
S
F
D
D
G
---
S
S
M
-
R
-
V
-
T
----
S
-
D
W
T
P
G
D
Q
-------
L
A
N
L
M
V
D
G
A
P
L
V
L
K
V
G
K
I
SGGF
R
I
R
T
R
G
A
D
L
K
V
H
V
R
T
P
R
Q
A
E
L
A
R
L
M
P
E
K
L
----------
P
P
---
D
-------
T
----
S
K
M
L
L
C
P
M
P
G
L
I
V
K
V
D
V
E
V
G
Q
E
V
Q
E
G
Q
A
L
C
T
I
E
A
M
K
M
E
N
I
L
R
A
E
K
K
G
V
V
A
K
I
N
A
S
A
G
N
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.04
46%
-96
- C3 -
-
1ULZ
-
?
A:
[3-443]
----
N
K
V
L
V
A
N
R
G
E
I
A
V
R
I
I
R
A
C
K
E
L
G
I
P
T
V
A
I
Y
N
E
V
E
S
T
A
R
H
V
K
L
A
D
E
A
Y
M
I
G
T
D
P
L
-
D
T
Y
L
N
K
Q
R
I
I
N
L
A
L
E
V
G
A
D
A
I
H
P
G
Y
G
F
L
A
E
N
A
E
F
A
K
M
C
E
E
A
G
I
T
F
I
G
P
H
W
K
V
I
E
L
M
G
D
K
A
R
S
K
E
V
M
K
K
A
G
V
P
V
V
P
G
S
D
G
V
-
L
K
S
L
E
E
A
K
A
L
A
R
E
I
G
Y
P
V
L
L
K
A
T
A
G
G
G
G
R
G
I
R
I
C
R
N
E
E
E
L
V
K
N
Y
E
Q
A
S
R
E
A
E
K
A
F
G
R
G
D
L
L
L
E
K
F
I
E
N
P
K
H
I
E
Y
Q
V
L
G
D
K
H
G
N
V
I
H
L
G
E
R
D
C
S
I
Q
R
R
N
Q
K
L
V
E
I
A
P
S
L
I
L
T
P
E
K
R
E
Y
Y
G
N
I
V
T
K
A
A
K
E
I
G
Y
Y
N
A
G
T
M
E
F
I
A
D
Q
-
E
-
G
N
L
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
S
E
M
V
T
G
I
D
I
V
K
W
Q
I
K
I
A
A
G
E
P
L
T
I
K
Q
E
D
V
K
F
N
G
Y
A
I
E
C
R
I
N
A
E
D
P
K
K
N
F
A
P
S
T
R
V
I
E
R
Y
Y
-
V
P
G
-
G
-
F
G
--
I
R
V
E
H
A
A
A
R
G
F
E
V
T
P
Y
Y
D
S
M
I
A
K
L
I
T
W
A
P
T
W
D
E
A
V
-
E
R
M
R
A
A
L
E
T
Y
E
I
T
G
V
K
T
T
I
P
L
L
I
N
I
M
K
E
K
D
F
K
A
G
K
F
T
T
K
Y
L
E
E
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Fugue
68.84
39%
-62
- C3 -
-
3N6R
1
?
A:
[2-681]
---
F
N
K
I
L
I
A
N
R
G
E
I
A
C
R
V
I
K
T
A
R
K
M
G
I
S
T
V
A
I
Y
S
D
A
D
K
Q
A
L
H
V
Q
M
A
D
E
A
V
H
I
G
P
P
P
A
N
Q
S
Y
I
V
I
D
K
V
M
A
A
I
R
A
T
G
A
Q
A
V
H
P
G
Y
G
F
L
S
E
N
S
K
F
A
E
A
L
E
A
E
G
V
I
F
V
G
-------------------------------------------------
P
P
K
G
A
I
E
A
M
G
---------------------
D
K
I
T
S
K
K
I
A
Q
E
A
N
V
S
T
V
P
G
V
T
Q
P
R
H
I
E
I
Q
V
L
C
D
S
H
G
N
G
I
Y
L
G
E
R
E
C
S
I
Q
R
R
N
Q
K
V
V
E
E
A
P
S
P
F
L
D
E
A
T
R
R
A
M
G
E
Q
A
V
A
L
A
K
A
V
G
Y
A
S
A
G
T
V
E
F
I
V
D
G
-
Q
-
K
N
F
Y
F
L
E
M
N
T
R
L
Q
V
E
H
P
V
T
E
L
I
T
G
V
D
L
V
E
Q
M
I
R
V
A
A
G
E
P
L
S
I
T
Q
G
D
V
K
L
T
G
W
A
I
E
N
R
L
Y
A
E
D
P
Y
R
G
F
L
P
S
I
G
R
L
T
R
Y
R
-
P
P
A
-
E
-
A
A
--
V
R
N
D
T
G
V
Y
E
G
G
E
I
S
M
Y
Y
D
P
M
I
A
K
L
C
T
W
A
P
T
R
A
A
A
I
-
E
A
M
R
I
A
L
D
S
F
E
V
E
G
I
G
H
N
L
P
F
L
S
A
V
M
D
H
P
K
F
I
S
G
D
M
T
T
A
F
I
A
E
E
Y
-
P
------
E
--
G
F
E
G
V
N
-----------
L
P
E
T
D
L
R
R
V
A
A
A
A
A
-
A
M
--------
H
R
V
A
----------
E
I
R
R
----
T
R
-
V
S
GRMDNH
E
R
R
V
G
T
E
W
V
V
T
L
Q
G
--
A
D
F
P
V
T
I
A
A
D
H
D
G
S
T
V
S
F
D
D
G
S
S
---
M
R
V
-
T
-
S
-
D
----
W
-
T
P
G
D
-
Q
L
-------
A
N
L
M
-
V
D
G
A
P
L
-----------
V
L
K
V
G
K
I
S
G
G
F
R
I
R
T
R
G
A
D
L
K
V
H
V
R
T
P
R
Q
----------
A
E
---
L
A
R
L
M
P
E
K
L
P
P
D
T
S
K
M
L
L
C
P
M
P
G
L
I
V
K
V
D
V
E
V
G
Q
E
V
Q
E
G
Q
A
L
C
T
I
E
A
M
K
M
E
N
I
L
R
A
E
K
K
G
V
V
A
K
I
N
A
S
A
G
N
S
L
A
V
D
D
V
I
M
E
F
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
68.54
41%
-57
- C3 -
-
3N6R
1
?
E:
[2-671]
---
F
N
K
I
L
I
A
N
R
G
E
I
A
C
R
V
I
K
T
A
R
K
M
G
I
S
T
V
A
I
Y
S
D
A
D
K
Q
A
L
H
V
Q
M
A
D
E
A
V
H
I
G
P
P
P
A
N
Q
S
Y
I
V
I
D
K
V
M
A
A
I
R
A
T
G
A
Q
A
V
H
P
G
Y
G
F
L
S
E
N
S
K
F
A
E
A
L
E
A
E
G
V
I
F
V
G
P
P
K
G
A
I
E
A
M
G
D
K
I
T
S
K
K
I
A
Q
E
A
N
V
S
T
V
P
G
----------------------------------------------------------------------
V
T
Q
P
R
H
I
E
I
Q
V
L
C
D
S
H
G
N
G
I
Y
L
G
E
R
E
C
S
I
Q
R
R
N
Q
K
V
V
E
E
A
P
S
P
F
L
D
E
A
T
R
R
A
M
G
E
Q
A
V
A
L
A
K
A
V
G
Y
A
S
A
G
T
V
E
F
I
V
D
G
-
Q
-
K
N
F
Y
F
L
E
M
N
T
R
L
Q
V
E
H
P
V
T
E
L
I
T
G
V
D
L
V
E
Q
M
I
R
V
A
A
G
E
P
L
S
I
T
Q
G
D
V
K
L
T
G
W
A
I
E
N
R
L
Y
A
E
D
P
Y
R
G
F
L
P
S
I
G
R
L
T
R
Y
R
-
P
P
A
E----AA
V
R
N
D
T
G
V
Y
E
G
G
E
I
S
M
Y
Y
D
P
M
I
A
K
L
C
T
W
A
P
T
R
A
A
A
I
-
E
A
M
R
I
A
L
D
S
F
E
V
E
G
I
G
H
N
L
P
F
L
S
A
V
M
D
H
P
K
F
I
S
G
D
M
T
T
A
F
I
A
E
E
Y
-
P
EGFEGV
N
--
L
-
P
E
T
D
LRRVAAAAAAM
H
R
V
A
E
I
R
R
T
R
V
S
G
R
-
M
D
--------
N
H
E
R
----------------------
R
---------
V
G
T
E
W
V
V
T
L
Q
G
--
A
D
--
F
P
V
T
I
A
A
D
H
D
G
S
T
V
S
F
D
D
G
---
S
S
M
-
R
-
V
-
T
----
S
-
D
W
T
P
G
D
Q
-------
L
A
N
L
M
V
D
G
A
P
L
VLKVGKISGGF
R
I
R
T
R
G
A
D
L
K
V
H
V
R
T
P
R
Q
A
E
L
A
R
L
M
P
E
K
L
----------
P
P
---
D
-------
T
----
S
K
M
L
L
C
P
M
P
G
L
I
V
K
V
D
V
E
V
G
Q
E
V
Q
E
G
Q
A
L
C
T
I
E
A
M
K
M
E
N
I
L
R
A
E
K
K
G
V
V
A
K
I
N
A
S
A
G
N
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
68.31
41%
-58
- C3 -
-
3N6R
1
?
A:
[2-671]
---
F
N
K
I
L
I
A
N
R
G
E
I
A
C
R
V
I
K
T
A
R
K
M
G
I
S
T
V
A
I
Y
S
D
A
D
K
Q
A
L
H
V
Q
M
A
D
E
A
V
H
I
G
P
P
P
A
N
Q
S
Y
I
V
I
D
K
V
M
A
A
I
R
A
T
G
A
Q
A
V
H
P
G
Y
G
F
L
S
E
N
S
K
F
A
E
A
L
E
A
E
G
V
I
F
V
G
P
P
K
G
A
I
E
A
M
G
D
K
I
T
S
K
K
I
A
Q
E
A
N
V
S
T
V
P
G
----------------------------------------------------------------------
V
T
Q
P
R
H
I
E
I
Q
V
L
C
D
S
H
G
N
G
I
Y
L
G
E
R
E
C
S
I
Q
R
R
N
Q
K
V
V
E
E
A
P
S
P
F
L
D
E
A
T
R
R
A
M
G
E
Q
A
V
A
L
A
K
A
V
G
Y
A
S
A
G
T
V
E
F
I
V
D
G
-
Q
-
K
N
F
Y
F
L
E
M
N
T
R
L
Q
V
E
H
P
V
T
E
L
I
T
G
V
D
L
V
E
Q
M
I
R
V
A
A
G
E
P
L
S
I
T
Q
G
D
V
K
L
T
G
W
A
I
E
N
R
L
Y
A
E
D
P
Y
R
G
F
L
P
S
I
G
R
L
T
R
Y
R
-
P
P
A
E----A
A
V
R
N
D
T
G
V
Y
E
G
G
E
I
S
M
Y
Y
D
P
M
I
A
K
L
C
T
W
A
P
T
R
A
A
A
I
-
E
A
M
R
I
A
L
D
S
F
E
V
E
G
I
G
H
N
L
P
F
L
S
A
V
M
D
H
P
K
F
I
S
G
D
M
T
T
A
F
I
A
E
E
Y
-
P
EGFE
G
V
N
--
L
-
P
E
T
D
L
R
R
V
A
A
A
A
A
A
M
H
R
V
A
E
I
R
R
T
R
V
S
G
R
-
M
D
--------
N
H
E
R
----------------------
R
---------
V
G
T
E
W
V
V
T
L
Q
G
--
A
D
--
F
P
V
T
I
A
A
D
H
D
G
S
T
V
S
F
D
D
G
---
S
S
M
-
R
-
V
-
T
----
S
-
D
W
T
P
G
D
Q
-------
L
A
N
L
M
V
D
G
A
P
L
V
L
K
V
G
K
I
SG
G
F
R
I
R
T
R
G
A
D
L
K
V
H
V
R
T
P
R
Q
A
E
L
A
R
L
M
P
E
K
L
----------
P
P
---
D
-------
T
----
S
K
M
L
L
C
P
M
P
G
L
I
V
K
V
D
V
E
V
G
Q
E
V
Q
E
G
Q
A
L
C
T
I
E
A
M
K
M
E
N
I
L
R
A
E
K
K
G
V
V
A
K
I
N
A
S
A
G
N
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
67.99
48%
-101
- C3 -
-
4RZQ
2
ACCC_HAEIN
A:
[22-462]
---
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
P
A
P
S
A
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
-----
A
K
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
----------
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
----------
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
S
F
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
K
T
-
F
L
P
S
P
G
K
V
N
H
L
H
-
S
P
G
-
G
-
L
G
--
V
R
W
D
S
H
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
-
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Fugue
67.80
47%
5
- C3 -
-
3U9T
-
?
A:
[46-639]
Y
R
S
I
Q
R
L
L
V
A
N
R
G
E
I
A
C
R
V
M
R
S
A
R
A
L
G
I
G
S
V
A
V
H
S
D
I
D
R
H
A
R
H
V
A
E
A
D
I
A
V
D
L
G
G
A
K
P
A
D
S
Y
L
R
G
D
R
I
I
A
A
A
L
A
S
G
A
Q
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
R
A
C
E
E
A
G
L
L
F
L
G
P
P
A
A
A
I
D
A
M
G
S
K
S
A
A
K
A
L
M
E
E
A
G
V
P
L
V
P
G
Y
H
G
E
-
A
Q
D
L
E
T
F
R
R
E
A
G
R
I
G
Y
P
V
L
L
K
A
A
------
A
M
K
V
V
E
R
E
A
E
L
A
E
A
L
--------
S
S
A
Q
R
A
R
M
L
V
E
K
Y
L
L
K
P
R
H
V
E
I
Q
V
F
A
D
R
H
G
H
C
L
Y
L
N
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
L
G
A
E
L
R
R
A
M
G
E
A
A
V
R
A
A
Q
A
I
G
Y
V
G
A
G
T
V
E
F
L
L
D
E
-
R
-
G
Q
F
F
F
M
E
M
N
T
R
L
Q
V
E
H
P
V
T
E
A
I
T
G
L
D
L
V
A
W
Q
I
R
V
A
R
G
E
A
L
P
L
T
Q
E
Q
V
P
L
N
G
H
A
I
E
V
R
L
Y
A
E
D
P
E
G
D
F
L
P
A
S
G
R
L
M
L
Y
R
E
A
A
A
-
G
-
P
G
--
R
R
V
D
S
G
V
R
E
G
D
E
V
S
P
F
Y
D
P
M
L
A
K
L
I
A
W
G
E
T
R
E
E
A
R
-
Q
R
L
L
A
M
L
A
E
T
S
V
G
G
L
R
T
N
L
A
F
L
R
R
I
L
G
H
P
A
F
A
A
A
E
L
D
T
G
F
I
A
R
H
Q
-
D
------
D
L
L
P
-
A
P
Q
A
-----------
L
P
E
H
F
W
Q
A
A
A
E
A
W
L
-
Q
S
--------
E
P
G
H
----------
R
R
D
D
----
D
P
-
H
S
---------
P
W
S
R
N
D
G
W
R
S
A
--
L
A
R
E
S
D
L
M
L
R
C
R
D
E
R
R
C
V
R
L
R
H
A
---
S
P
----
S
-
Q
----
Y
-
R
L
D
G
-
D
D
-------
L
V
S
R
-
V
D
G
V
T
R
-----------
R
S
A
A
L
R
R
G
R
Q
L
F
L
E
W
E
G
E
L
L
A
I
E
A
V
D
P
I
A
----------
E
A
---
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.79
47%
-51
- C3 -
-
2VPQ
1
?
A:
[3-444]
-----
K
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
C
V
G
P
T
L
S
K
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
V
P
G
S
D
G
L
-
M
K
D
V
S
E
A
K
K
I
A
K
K
I
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
E
M
G
N
A
A
V
R
A
A
K
A
V
N
Y
E
N
A
G
T
I
E
F
I
Y
D
L
-
N
D
N
K
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
D
V
L
P
Y
K
Q
E
D
I
K
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
F
M
P
S
P
G
K
I
E
Q
Y
L
-
A
P
G
-
G
-
Y
G
--
V
R
I
E
S
A
C
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
H
E
P
T
R
D
E
A
I
-
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
Q
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
66.48
47%
-49
- C3 -
-
2VPQ
1
?
B:
[3-444]
-----
K
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
C
V
G
P
T
L
S
K
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
V
P
G
S
D
G
L
-
M
K
D
V
S
E
A
K
K
I
A
K
K
I
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
E
M
G
N
A
A
V
R
A
A
K
A
V
N
Y
E
N
A
G
T
I
E
F
I
Y
D
L
-
N
D
N
K
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
D
V
L
P
Y
K
Q
E
D
I
K
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
F
M
P
S
P
G
K
I
E
Q
Y
L
-
A
P
G
-
G
-
Y
G
--
V
R
I
E
S
A
C
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
H
E
P
T
R
D
E
A
I
-
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
Q
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
66.46
48%
-99
- C3 -
-
4MV9
3
ACCC_HAEIN
A:
[22-462]
---
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
P
A
P
S
A
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
V
P
G
S
D
----
N
D
I
A
K
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
-----------
V
V
R
S
E
D
A
L
E
E
-------------------
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
S
F
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
K
T
-
F
L
P
S
P
G
K
V
N
H
L
H
-
S
P
G
-
G
-
L
G
--
V
R
W
D
S
H
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
-
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
HHSearch
66.40
47%
-48
- C3 -
-
2VPQ
1
?
B:
[2-446]
----
K
K
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
C
V
G
P
T
L
S
K
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
V
P
G
S
D
G
L
-
M
K
D
V
S
E
A
K
K
I
A
K
K
I
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
E
M
G
N
A
A
V
R
A
A
K
A
V
N
Y
E
N
A
G
T
I
E
F
I
Y
D
L
N
D
-
N
K
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
D
V
L
P
Y
K
Q
E
D
I
K
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
F
M
P
S
P
G
K
I
E
Q
Y
L
-
A
P
G
-
G
-
Y
G
--
V
R
I
E
S
A
C
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
H
E
P
T
R
D
E
A
I
-
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
Q
N
S
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
66.40
48%
-25
- C3 -
-
2W71
1
ACCC_ECOLI
C:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
66.13
47%
-30
- C3 -
-
3G8D
1
ACCC_ECOLI
B:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
A
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
66.00
48%
-26
- C3 -
-
2W6N
1
ACCC_ECOLI
B:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
65.98
48%
-28
- C3 -
-
2V58
1
ACCC_ECOLI
B:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
65.88
47%
-28
- C3 -
-
3RV4
3
ACCC_ECOLI
A:
[5-445]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
E
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
65.83
48%
-30
- C3 -
-
2W6O
1
ACCC_ECOLI
A:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
65.73
48%
-25
- C3 -
-
2V5A
1
ACCC_ECOLI
A:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
65.73
47%
-27
- C3 -
-
3JZI
1
ACCC_ECOLI
A:
[23-466]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
65.72
47%
-23
- C3 -
-
1DV2
1
ACCC_ECOLI
B:
[5-445]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
K
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
65.72
48%
-27
- C3 -
-
2W70
1
ACCC_ECOLI
B:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
65.71
48%
-26
- C3 -
-
2J9G
1
ACCC_ECOLI
A:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
--
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
65.67
47%
-29
- C3 -
-
3JZI
1
ACCC_ECOLI
B:
[23-465]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
65.64
48%
-27
- C3 -
-
2W71
1
ACCC_ECOLI
A:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
65.48
47%
-24
- C3 -
-
3JZF
1
ACCC_ECOLI
B:
[23-466]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
K
L
G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
65.31
48%
-26
- C3 -
-
2W70
1
ACCC_ECOLI
A:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
65.30
48%
-28
- C3 -
-
3RUP
2
ACCC_ECOLI
A:
[5-445]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
65.25
48%
-23
- C3 -
-
3G8C
2
ACCC_ECOLI
B:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
65.25
48%
-28
- C3 -
-
3RV3
2
ACCC_ECOLI
A:
[5-445]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
65.21
48%
-30
- C3 -
-
2VR1
1
ACCC_ECOLI
A:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
--
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
65.20
48%
-27
- C3 -
-
3G8C
2
ACCC_ECOLI
A:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
65.14
47%
-29
- C3 -
-
1DV2
1
ACCC_ECOLI
A:
[5-445]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
K
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
65.12
48%
-26
- C3 -
-
2V59
1
ACCC_ECOLI
A:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
65.11
48%
-28
- C3 -
-
2J9G
1
ACCC_ECOLI
B:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
--
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
---
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
65.07
48%
-25
- C3 -
-
2W6P
1
ACCC_ECOLI
A:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
65.06
48%
-26
- C3 -
-
2W6N
1
ACCC_ECOLI
A:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
64.98
48%
-24
- C3 -
-
2V58
1
ACCC_ECOLI
A:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.96
48%
-25
- C3 -
-
4MV4
3
ACCC_HAEIN
A:
[22-462]
---
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
P
A
P
S
A
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
V
S
N
D
I
A
K
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
G
G
G
---
M
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
A
K
A
A
F
N
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
S
F
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
K
T
-
F
L
P
S
P
G
K
V
N
H
L
H
-
S
P
G
-
G
-
L
G
--
V
R
W
D
S
H
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
-
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
64.91
45%
-27
- C3 -
-
2VQD
1
ACCC_PSEAE
A:
[2-447]
---
L
E
K
V
L
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
E
L
M
H
L
S
L
A
D
E
S
V
C
I
G
P
A
P
A
T
Q
S
Y
L
Q
I
P
A
I
I
A
A
A
E
V
T
G
A
T
A
I
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
Q
I
E
R
S
G
F
T
F
V
G
P
T
A
E
V
I
R
L
M
G
D
K
V
S
A
K
D
A
M
K
R
A
G
V
P
T
V
P
G
S
D
G
P
L
P
E
D
E
E
T
A
L
A
I
A
R
E
V
G
Y
P
V
I
I
K
A
A
G
G
G
G
G
R
G
M
R
V
V
Y
D
E
S
E
L
I
K
S
A
K
L
T
R
T
E
A
G
A
A
F
G
N
P
M
V
Y
L
E
K
F
L
T
N
P
R
H
V
E
V
Q
V
L
S
D
G
Q
G
N
A
I
H
L
G
D
R
D
C
S
L
Q
R
R
H
Q
K
V
I
E
E
A
P
A
P
G
I
D
E
K
A
R
Q
E
V
F
A
R
C
V
Q
A
C
I
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
E
--
N
-
G
R
F
Y
F
I
E
M
N
T
R
V
Q
V
E
H
P
V
S
E
M
V
T
G
V
D
I
V
K
E
M
L
R
I
A
S
G
E
K
L
S
I
R
Q
E
D
V
V
I
R
G
H
A
L
E
C
R
I
N
A
E
D
P
K
T
-
F
M
P
S
P
G
K
V
K
H
F
H
-
A
P
G
-
G
-
N
G
--
V
R
V
D
S
H
L
Y
S
G
Y
S
V
P
P
N
Y
D
S
L
V
G
K
V
I
T
Y
G
A
D
R
D
E
A
L
-
A
R
M
R
N
A
L
D
E
L
I
V
D
G
I
K
T
N
T
E
L
H
K
D
L
V
R
D
A
A
F
C
K
G
G
V
N
I
H
Y
L
E
K
K
L
-
G
------
M
--
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
64.91
48%
-29
- C3 -
-
3RUP
2
ACCC_ECOLI
B:
[5-445]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
64.81
48%
-23
- C3 -
-
2W6O
1
ACCC_ECOLI
C:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
64.78
48%
-25
- C3 -
-
2V59
1
ACCC_ECOLI
B:
[2-442]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
64.75
48%
-26
- C3 -
-
3RV3
2
ACCC_ECOLI
B:
[5-445]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
Q
P
L
S
I
K
Q
E
E
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
-
A
P
G
-
G
-
F
G
--
V
R
W
E
S
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
-
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.68
48%
-27
- C3 -
-
4MV1
3
ACCC_HAEIN
A:
[22-462]
---
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
P
A
P
S
A
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
V
S
N
D
I
A
K
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
------
M
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
--------
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
S
F
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
K
T
-
F
L
P
S
P
G
K
V
N
H
L
H
-
S
P
G
-
G
-
L
G
--
V
R
W
D
S
H
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
-
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.52
48%
-25
- C3 -
-
4MV3
2
ACCC_HAEIN
A:
[22-462]
---
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
P
A
P
S
A
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
V
S
N
D
I
A
K
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
------
M
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
A
K
A
A
F
N
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
S
F
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
K
T
-
F
L
P
S
P
G
K
V
N
H
L
H
-
S
P
G
-
G
-
L
G
--
V
R
W
D
S
H
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
-
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
63.94
48%
-26
- C3 -
-
4MV8
1
ACCC_HAEIN
A:
[22-462]
---
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
P
A
P
S
A
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
V
P
G
S
D
G
P
V
S
N
D
I
A
K
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
G
-----
M
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
----------
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
E
--
N
-
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
S
F
K
Q
E
D
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
K
T
-
F
L
P
S
P
G
K
V
N
H
L
H
-
S
P
G
-
G
-
L
G
--
V
R
W
D
S
H
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
-
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Fugue
62.68
33%
9
- C3 -
-
3VA7
9
?
A:
[28-1236]
K
K
P
F
E
T
V
L
I
A
N
R
G
E
I
A
V
R
I
M
K
T
L
K
R
M
G
I
K
S
V
A
V
Y
S
D
P
D
K
Y
S
Q
H
V
T
D
A
D
F
S
V
A
L
H
G
R
T
A
A
E
T
Y
L
D
I
D
K
I
I
N
A
A
K
K
T
G
A
Q
A
I
I
P
G
Y
G
F
L
S
E
N
A
D
F
S
D
R
C
S
Q
--------------------------------------------------------
E
N
I
V
F
V
G
P
S
G
D
A
I
R
K
L
G
L
K
H
S
A
R
E
I
A
E
R
A
K
V
P
L
V
P
N
-----------------
A
R
H
V
E
I
Q
M
M
G
D
G
F
G
K
A
I
A
I
G
E
R
D
C
S
L
Q
R
R
N
Q
K
V
I
E
E
T
P
A
P
N
L
P
E
A
T
R
A
K
M
R
A
A
S
E
R
L
G
S
L
L
K
Y
K
C
A
G
T
V
E
F
I
Y
D
E
Q
R
-
D
E
F
Y
F
L
E
V
N
A
R
L
Q
V
E
H
P
I
T
E
M
V
T
G
L
D
L
V
E
W
M
L
R
I
A
A
N
D
S
P
D
F
D
N
T
K
I
E
V
S
G
A
S
I
E
A
R
L
Y
A
E
N
P
V
K
D
F
R
P
S
P
G
Q
L
T
S
V
S
-
F
P
----
S
W
--
A
R
V
D
T
W
V
K
K
G
T
N
V
S
A
E
Y
D
P
T
L
A
K
I
I
V
H
G
K
D
R
N
D
A
I
-
M
K
L
N
Q
A
L
N
E
T
A
V
Y
G
C
I
T
N
I
D
Y
L
R
S
I
A
S
S
K
M
F
K
E
A
K
V
A
T
K
V
L
D
S
F
D
-
Y
------
K
--
P
-
C
A
F
E
-----------
V
L
A
P
G
A
N
T
-----
S
-
V
Q
--------
D
Y
P
G
----------
R
T
G
Y
----
W
R
-
I
G
---------
V
P
P
S
G
P
M
------
D
S
Y
S
F
R
L
A
N
R
V
V
G
N
N
S
K
S
P
A
L
E
I
---
T
L
N
-
G
-
P
-
K
----
L
-
L
F
H
T
-
E
T
-------
V
I
A
V
-
S
G
----------------
G
T
V
S
C
T
L
N
D
A
Q
I
A
Q
N
E
P
I
E
V
K
R
G
D
I
L
S
V
----------
G
K
---
V
-------
T
V
------------
G
C
R
A
Y
L
S
I
R
G
G
--------------
I
D
V
P
E
Y
L
G
S
R
S
T
F
A
M
G
N
M
G
G
Y
N
G
R
I
L
K
L
G
D
V
L
F
L
N
Q
P
ELSVSSLPAPDFEPQAAPKSL
L
P
T
L
S
TNK
D
W
K
I
G
V
T
C
GPHGSIDLFK
E
E
Y
I
E
Q
F
F
N
D
K
W
K
V
H
YNSNRF
G
V
R
L
I
G
P
K
P
K
W
ARSDGGEAGLHPSNAH
D
Y
V
Y
S
LGAINFTGD
E
P
V
I
I
T
CDGPSLGGFVCQAVVAEAE
L
W
K
V
G
Q
LTPG
D
T
I
Q
F
V
P
L
S
Y
G
V
A
R
Q
L
K
E
S
Q
D
K
S
I
D
NFEEGSLLELSDDKILPKYENPIL
A
V
L
P
KKSDLS
P
K
V
T
Y
R
Q
A
G
DR
Y
I
L
V
E
Y
G
ELEFD
L
N
I
C
Y
R
I
N
R
L
I
H
Q
V
E
R
H
QTVGIV
E
M
S
Q
G
VR
S
V
L
I
E
F
D
GSKIN
Q
K
A
L
L
K
C
L
I
A
Y
E
S
E
I
Q
F
D
KN
W
N
V
K
S
K
I
F
K
L
P
M
A
F
ED
S
K
T
L
D
C
V
T
R
Y
R
E
TIRSEAPWLPN
N
V
D
F
I
A
D
V
N
DID
R
N
D
V
K
N
M
L
Y
S
A
K
F
M
V
LGLGDVFLGSPCAVPLDPRH
R
Y
L
G
T
K
Y
NPSRTYTARG
V
V
G
I
G
GM
Y
M
C
I
YNAEGSPGGYQLV
G
R
T
I
TAWDKLVIGDHPIDHPWLLTPF
D
Q
V
E
F
Y
P
V
T
E
E
E
L
E
V
I
I
E
D
N
D
N
GKFKID
V
E
E
S
I
F
D
H
K
E
Y
L
A
W
I
N
E
N
I
D
S
I
V
A
F
Q
E
A
QGG
E
K
A
D
E
F
A
R
L
I
Q
VANAELKKSEEYPDDAE
L
L
Y
S
E
Y
T
G
R
FWKPVAAVG
D
H
V
E
AGDGVIIIEAMKTE
M
V
V
G
A
T
K
S
G
K
VYKILHKNG
D
M
V
E
AGDLVAVIV
106
PsiBlast_CBE
57.33
40%
-28
- C3 -
-
3VA7
6
?
A:
[31-512]
---
F
E
T
V
L
I
A
N
R
G
E
I
A
V
R
I
M
K
T
L
K
R
M
G
I
K
S
V
A
V
Y
S
D
P
D
K
Y
S
Q
H
V
T
D
A
D
F
S
V
A
L
H
G
R
T
A
A
E
T
Y
L
D
I
D
K
I
I
N
A
A
K
K
T
G
A
Q
A
I
I
P
G
Y
G
F
L
S
E
N
A
D
F
S
D
R
C
S
Q
E
N
I
V
F
V
G
P
S
G
D
A
I
R
K
L
G
L
K
H
S
A
R
E
I
A
E
R
A
K
V
P
L
V
P
-------------------------------------------------------------------------
N
A
R
H
V
E
I
Q
M
M
G
D
G
F
G
K
A
I
A
I
G
E
R
D
C
S
L
Q
R
R
N
Q
K
V
I
E
E
T
P
A
P
N
L
P
E
A
T
R
A
K
M
R
A
A
S
E
R
L
G
S
L
L
K
Y
K
C
A
G
T
V
E
F
I
Y
D
E
-
Q
R
D
E
F
Y
F
L
E
V
N
A
R
L
Q
V
E
H
P
I
T
E
M
V
T
G
L
D
L
V
E
W
M
L
R
I
A
A
N
D
S
P
D
F
D
N
T
K
I
E
V
S
G
A
S
I
E
A
R
L
Y
A
E
N
P
V
K
D
F
R
P
S
P
G
Q
L
T
S
----
V
S
-
F
-
P
S
W-
A
R
V
D
T
W
V
K
K
G
T
N
V
S
A
E
Y
D
P
T
L
A
K
I
I
V
H
G
K
D
R
N
D
A
I
-
M
K
L
N
Q
A
L
N
E
T
A
V
Y
G
C
I
T
N
I
D
Y
L
R
S
I
A
S
S
K
M
F
K
E
A
K
V
A
T
K
V
L
D
-----------------
S
F
D
-----------
Y
K
P
C
A
F
E
V
L
A
P
G
A
N
-
T
S
--------
V
Q
D
Y
----------
P
G
R
T
----
G
Y
-
W
R
---------
I
G
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------