@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VVA4: (2017-12-23 )
MVDFAEHRKALLCNDAQSIADYESAMGEAVKAVSAWLQNEKMYTGGSIKELRSAISFQPSKEGMGVQQSLQRMIELFLNKSLKVHHPHSLAHLHCPTMVMSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIDWLRQKVGYGSGQAGVFTSGGTQSNLMGVLLARDWCIAKNWKDENGNPWSGQRDGIPAEAMKNVKVICSENAHFSVQKNMAMMGMGFQSVVTVPVNENAQMDVDALEKTMAHLQAEGKVVACVVATAGTTDAGAIDPLKKIREITNKYGSWMHIDAAWGGALILSNDYRAMLDGIELSDSITLDFHKHYFQSISCGAFLLKDEANYRFMHYEAEYLNSAYDEEHGVPNLVSKSLQTTRRFDALKLWMTIESLGEELYGSMIDHGVKLTREVADYIKATDGLELLVEPQFASVLFRVVPEGYPVEFIDSLNQNVADELFARGEANIGVTKVGNVQSLKMTTLSPVVTVDNVKNLLAQVLAEAERIKDAIASGNYVPPID
Atome Classification :
(20 SA)
.........10........20........30.-.-...-..-----.-----40--.........50....-..--..60.-.......70........80........90........100.......110.......120.......130.......140-..--------..-...150.......160.......170.......180.......--190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330...----------.---.-.-.-340---...-....---.350.......360.......370.......380.......390.......400.......410.....--.--.420.......430--..--------.-----.--....440.......450----.......460-..-.....470.......480.......490.......500.......510
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MV
D
F
A
E
H
R
K
A
L
LCN
D
A
Q
S
I
A
D
Y
E
S
A
M
G
E
A
V
K
A
-
V
-
S
A
W
-
L
Q-----N-----E---KMYTGG
S
I
K
E
L
R
S
A
I-SF--QPSKE-GM
G
V
Q
Q
S
L
Q
R
M
I
E
L
F
L
NKS
L
K
VHHPHS
L
A
HLH
C
P
T
M
V
M
S
Q
I
A
E
V
L
I
N
ATNQSMDSWDQSPAG
S
L
M
E
V
Q
L
I
D
W
L
R
Q
KVGYG-SG--------QA-
G
V
F
TSGGTQSN
L
M
G
V
L
L
ARD
W
C
I
AKNWKDENGNPWSGQRDGI
P
--
A
E
A
MK
N
V
K
V
I
CSENA
H
F
S
V
Q
K
N
M
A
M
MGMGF
Q
S
V
V
T
V
PVNENAQM
D
V
D
A
L
E
K
T
M
A
H
L
QAEG
K
V
V
A
C
V
V
ATAGTTDAGA
I
D
P
L
K
K
I
R
E
I
T
N
KYG
S
W
M
H
I
DAAWG
G
A
L
I
LSN
D
Y
R
A
M
LDGIELSD
S
I
T
L
D
F
H
K
H
Y
F
Q
SISC
G
A
F
L
L
KDE----------A---N-
Y
-
R
-
F
-
M
---
H
Y
E
-
A
E
Y
L
---
N
S
AYDEEHG
V
P
N
L
V
S
K
S
L
Q
T
T
R
R
F
D
A
L
K
L
W
M
T
I
E
S
L
G
E
E
L
Y
G
S
M
I
D
H
G
V
K
L
T
R
E
V
A
D
Y
I
KATDG
L
E
L
L
V--E--P
Q
F
A
S
V
L
F
R
VVPE---GY--------
P
-----
V
--
E
F
I
D
S
L
N
Q
N
V
A
D
E
L
F
AR----GEANI
G
V
T
KV-G
N
-
V
Q
S
L
K
M
TTLS
P
V
V
T
V
D
N
V
K
N
L
L
A
Q
V
L
A
E
A
E
R
I
K
D
A
I
ASGNYVPPID
26
HHSearch
79.46
40%
-17
- C1 -
-
2QMA
2
?
A:
[16-496]
---
Q
E
E
W
K
K
H
F
I
H
T
G
E
L
G
S
A
E
F
A
S
V
M
S
H
T
T
S
A
M
K
-
S
V
F
-
E
Q
-----
V
-----
N
---
A
P
Y
S
G
M
D
P
K
A
L
E
D
A
I
-
N
A
--
V
D
L
D
N
K
N
A
P
L
K
S
V
I
D
D
V
A
E
L
V
A
K
N
A
I
F
T
Q
H
P
D
C
I
A
H
L
H
T
P
P
L
M
P
A
V
A
A
E
A
M
I
A
A
L
N
Q
S
M
D
S
W
D
Q
A
S
S
A
T
Y
V
E
Q
K
V
V
N
W
L
C
D
K
Y
D
L
S
-
E
K
--------
A
D
-
G
I
F
T
S
G
G
T
Q
S
N
Q
M
G
L
M
L
A
R
D
W
I
A
D
K
L
------
S
G
H
S
I
Q
K
L
G
L
P
--
D
Y
A
D
K
-
L
R
I
V
C
S
K
K
S
H
F
T
V
Q
K
S
A
S
W
M
G
L
G
E
K
A
V
M
T
V
D
A
N
A
D
G
T
M
D
I
T
K
L
D
E
V
I
A
Q
A
K
A
E
G
L
I
P
F
A
I
V
G
T
A
G
T
T
D
H
G
A
I
D
D
L
D
F
I
A
D
M
A
V
K
H
D
M
W
M
H
V
D
G
A
Y
G
G
A
L
I
L
S
S
-
H
K
S
R
L
K
G
V
E
R
A
H
S
I
S
V
D
F
H
K
L
F
Y
Q
T
I
S
C
G
A
L
L
V
N
D
K
----------
S
---
N
-
F
-
K
-
F
-
L
---
L
H
---------------------------
A
T
T
K
R
F
D
A
L
K
V
F
M
T
M
Q
N
V
G
P
K
A
L
G
D
M
Y
D
H
L
L
A
Q
T
L
E
V
A
D
M
I
R
T
N
D
Q
F
E
L
L
A
--
E
--
P
S
L
S
T
V
L
F
R
A
T
H
E
---
T
A
------------------
D
L
D
E
L
N
K
A
L
R
L
E
A
L
T
R
----
G
I
A
V
L
G
E
T
I
V
-
D
G
-
K
T
A
L
K
F
T
I
L
N
P
C
L
T
T
S
D
F
E
S
L
L
S
K
I
N
M
L
A
V
E
L
--------------
1
PsiBlast_PDB
75.83
38%
-17
- C1 -
-
2QMA
2
?
A:
[32-489]
-------------------
A
E
F
A
S
V
M
S
H
T
T
S
A
-
M
K
S
V
F
-
E
Q
-----
V
-----
N
---
A
P
Y
S
G
M
D
P
K
A
L
E
D
A
I
N
A
V
--
D
L
D
N
K
-
N
A
P
L
K
S
V
I
D
D
V
A
E
L
V
A
K
N
A
I
F
T
Q
H
P
D
C
I
A
H
L
H
T
P
P
L
M
P
A
V
A
A
E
A
M
I
A
A
L
N
Q
S
M
D
S
W
D
Q
A
S
S
A
T
Y
V
E
Q
K
V
V
N
W
L
C
D
K
Y
D
L
S
-
E
K
--------
A
D
-
G
I
F
T
S
G
G
T
Q
S
N
Q
M
G
L
M
L
A
R
D
W
I
A
D
K
----
L
S
G
H
--
S
I
Q
K
L
G
L
P
--
D
Y
A
D
K
-
L
R
I
V
C
S
K
K
S
H
F
T
V
Q
K
S
A
S
W
M
G
L
G
E
K
A
V
M
T
V
D
A
N
A
D
G
T
M
D
I
T
K
L
D
E
V
I
A
Q
A
K
A
E
G
L
I
P
F
A
I
V
G
T
A
G
T
T
D
H
G
A
I
D
D
L
D
F
I
A
D
M
A
V
K
H
D
M
W
M
H
V
D
G
A
Y
G
G
A
L
I
L
S
S
-
H
K
S
R
L
K
G
V
E
R
A
H
S
I
S
V
D
F
H
K
L
F
Y
Q
T
I
S
C
G
A
L
L
V
N
D
K
----------
S
---
N
-
F
-
K
-
F
-
L
---
L
H
---------------------------
A
T
T
K
R
F
D
A
L
K
V
F
M
T
M
Q
N
V
G
P
K
A
L
G
D
M
Y
D
H
L
L
A
Q
T
L
E
V
A
D
M
I
R
T
N
D
Q
F
E
L
L
A
--
E
--
P
S
L
S
T
V
L
F
R
A
T
H
E
---
T
A
--------
D
----------
L
D
E
L
N
K
A
L
R
L
E
A
L
T
R
----
G
I
A
V
L
G
E
T
I
V
-
D
G
-
K
T
A
L
K
F
T
I
L
N
P
C
L
T
T
S
D
F
E
S
L
L
S
K
I
---------------------
3
PsiBlast_PDB
73.73
27%
-77
- C1 -
-
4OBU
2
?
E:
[67-473]
-------------------------------------------------------------------------------
E
K
-
G
R
P
V
N
E
V
V
S
E
M
M
N
E
V
Y
R
Y
R
G
D
A
N
H
P
R
F
F
S
F
V
P
G
P
A
S
S
V
S
W
L
G
D
I
M
T
S
A
Y
N
I
H
A
G
G
S
K
L
A
P
M
V
N
C
I
E
Q
E
V
L
K
W
L
A
K
Q
V
G
F
T
-
E
N
--------
P
G
-
G
V
F
V
S
G
G
S
M
A
N
I
T
A
L
T
A
A
R
D
----
N
K
L
T
D
I
N
-----------------
L
H
L
G
T
A
Y
I
S
D
Q
T
H
S
S
V
A
K
G
L
R
I
I
G
I
T
D
S
R
I
R
R
I
P
T
N
S
H
F
Q
M
D
T
T
K
L
E
E
A
I
E
T
D
K
K
S
G
Y
I
P
F
V
V
I
G
T
A
G
T
T
N
T
G
S
I
D
P
L
T
E
I
S
A
L
C
K
K
H
D
M
W
F
H
I
D
G
A
Y
G
A
S
V
L
L
S
P
K
Y
K
S
L
L
T
G
T
G
L
A
D
S
I
S
W
D
A
H
K
W
L
F
Q
T
Y
G
C
A
M
V
L
V
K
D
I
----------
R
---
N
L
F
-
H
-
S
-
F
---
H
V
N
-
P
E
Y
L
-----------------
D
I
G
M
E
L
T
R
P
A
R
G
L
K
L
W
L
T
L
Q
V
L
G
S
D
L
I
G
S
A
I
E
H
G
F
Q
L
A
V
W
A
E
E
A
L
N
P
K
K
D
W
E
I
V
S
--
P
--
A
Q
M
A
M
I
N
F
R
Y
A
P
K
---
D
L
--------
T
-----
K
--
E
E
Q
D
I
L
N
E
K
I
S
H
R
I
L
E
S
----
G
Y
A
A
I
F
T
T
V
L
-
N
G
-
K
T
V
L
R
I
C
A
I
H
P
E
A
T
Q
E
D
M
Q
H
T
I
------------------------
6
PsiBlast_PDB
73.20
29%
-81
- C1 -
-
4RM1
3
?
B:
[63-474]
--------------------------------------------------------------------------------
E
-
A
A
A
T
E
A
T
L
L
Q
A
I
R
D
M
V
D
G
S
M
N
P
A
N
P
G
Y
I
G
H
M
D
P
M
P
A
T
M
A
I
L
G
D
L
V
A
A
A
V
N
N
N
M
L
S
L
E
M
S
P
S
F
S
R
L
E
T
L
L
L
R
A
I
A
G
L
F
G
L
G
-
E
Q
--------
A
G
-
G
V
L
T
S
G
G
S
L
A
N
L
Q
A
L
------
A
V
A
R
N
V
A
F
D
S
V
E
P
------
G
I
T
--
G
L
A
Q
R
P
V
-
I
F
A
S
E
A
A
H
T
S
L
Q
K
A
A
M
L
L
G
L
G
T
A
A
V
I
P
V
R
A
T
A
D
S
R
M
D
P
E
D
L
R
A
R
I
D
Q
A
R
G
A
G
Q
H
P
F
C
V
V
A
T
A
G
T
T
T
T
G
N
I
D
P
L
A
E
I
G
A
I
A
R
E
H
G
L
W
F
H
V
D
A
A
Y
G
G
A
L
V
F
S
E
R
H
R
W
R
L
A
G
I
E
Q
A
D
S
I
T
F
N
P
Q
K
W
L
Y
V
A
K
T
C
A
M
V
L
F
R
D
A
----------
G
---
V
-
L
E
R
-
A
-
F
---
R
I
P
-
A
P
Q
M
---
R
A
T
----
D
G
F
I
N
L
G
E
I
G
V
Q
G
T
R
H
A
D
V
V
K
L
W
L
T
L
Q
H
I
G
Q
Q
G
Y
A
R
L
I
D
D
G
Y
R
L
A
E
R
V
V
E
G
V
R
Q
R
P
F
L
R
L
A
G
--
E
--
I
D
T
N
I
V
C
F
R
G
E
P
D
---
W
L
--------
P
-----
A
--
E
R
W
D
D
W
N
A
A
L
Q
A
L
L
L
R
E
----
G
K
I
F
L
S
L
P
V
Y
-
R
G
-
G
R
W
L
R
A
V
L
L
N
P
Y
T
T
D
A
V
I
D
A
M
F
K
Q
I
---------------------
4
PsiBlast_PDB
72.80
27%
-69
- C1 -
-
4OBV
3
?
D:
[67-473]
-------------------------------------------------------------------------------
E
K
-
G
R
P
V
N
E
V
V
S
E
M
M
N
E
V
Y
R
Y
R
G
D
A
N
H
P
R
F
F
S
F
V
P
G
P
A
S
S
V
S
W
L
G
D
I
M
T
S
A
Y
N
I
H
A
G
G
S
K
L
A
P
M
V
N
C
I
E
Q
E
V
L
K
W
L
A
K
Q
V
G
F
T
-
E
N
--------
P
G
-
G
V
F
V
S
G
G
S
M
A
N
I
T
A
L
T
A
A
R
D
----
N
K
L
T
D
I
N
-----------------
L
H
L
G
T
A
Y
I
S
D
Q
T
H
S
S
V
A
K
G
L
R
I
I
G
I
T
D
S
R
I
R
R
I
P
T
N
S
H
F
Q
M
D
T
T
K
L
E
E
A
I
E
T
D
K
K
S
G
Y
I
P
F
V
V
I
G
T
A
G
T
T
N
T
G
S
I
D
P
L
T
E
I
S
A
L
C
K
K
H
D
M
W
F
H
I
D
G
A
Y
G
A
S
V
L
L
S
P
K
Y
K
S
L
L
T
G
T
G
L
A
D
S
I
S
W
D
A
H
K
W
L
F
Q
T
Y
G
C
A
M
V
L
V
K
D
I
----------
R
---
N
L
F
-
H
-
S
-
F
---
H
V
N
-
P
E
Y
L
---
K
D
L
E
---
D
N
V
-
N
T
W
D
I
G
M
E
L
T
R
P
A
R
G
L
K
L
W
L
T
L
Q
V
L
G
S
D
L
I
G
S
A
I
E
H
G
F
Q
L
A
V
W
A
E
E
A
L
N
P
K
K
D
W
E
I
V
S
--
P
--
A
Q
M
A
M
I
N
F
R
Y
A
P
K
---
D
L
--------
T
-----
K
--
E
E
Q
D
I
L
N
E
K
I
S
H
R
I
L
E
S
----
G
Y
A
A
I
F
T
T
V
L
-
N
G
-
K
T
V
L
R
I
C
A
I
H
P
E
A
T
Q
E
D
M
Q
H
T
I
------------------------
46
Fugue
72.50
21%
-26
- C1 -
-
1JS3
3
DDC_PIG
A:
[1-476]
-------------
M
N
A
S
D
F
R
R
R
G
K
E
M
V
D
Y
M
A
D
-
Y
-
L
E
G
-
I
E
-----
G
-----
R
---
Q
V
Y
P
D
V
Q
P
G
Y
L
R
P
L
I
-
P
A
--
T
A
P
Q
E
-
P
D
T
F
E
D
I
L
Q
D
V
E
K
I
I
M
P
G
V
T
H
W
H
S
P
Y
F
F
A
Y
F
P
T
A
S
S
Y
P
A
M
L
A
D
M
L
C
G
A
I
G
C
I
G
F
S
W
A
A
S
P
A
C
T
E
L
E
T
V
M
M
D
W
L
G
K
M
L
Q
L
P
-
E
A
FLAGEAGE
G
G
-
G
V
I
Q
G
S
A
S
E
A
T
L
V
A
L
L
A
A
R
T
K
V
V
R
R
L
Q
A
A
S
P
G
L
T
--------
Q
--
G
A
V
L
E
K
L
V
A
Y
A
S
D
Q
A
H
S
S
V
E
R
A
G
L
I
G
G
V
---
K
L
K
A
I
P
S
D
G
K
F
A
M
R
A
S
A
L
Q
E
A
L
E
R
D
K
A
A
G
L
I
P
F
F
V
V
A
T
L
G
T
T
S
C
C
S
F
D
N
L
L
E
V
G
P
I
C
H
E
E
D
I
W
L
H
V
D
A
A
Y
A
G
S
A
F
I
C
P
E
F
R
H
L
L
N
G
V
E
F
A
D
S
F
N
F
N
P
H
K
W
L
L
V
N
F
D
C
S
A
M
W
V
K
R
-------------------------------
R
T
D
L
---
T
G
A
F
K
S
G
L
-
I
T
D
Y
R
H
W
Q
L
P
L
G
R
R
F
R
S
L
K
M
W
F
V
F
R
M
Y
G
V
K
G
L
Q
A
Y
I
R
K
H
V
Q
L
S
H
E
F
E
A
F
V
L
Q
D
P
R
F
E
V
C
A
--
E
--
V
T
L
G
L
V
C
F
R
L
K
G
S
-------------------------
D
G
L
N
E
A
L
L
E
R
I
N
S
A
----
R
K
I
H
L
V
P
C
R
L
-
R
G
-
Q
F
V
L
R
F
A
I
C
S
R
K
V
E
S
G
H
V
R
L
A
W
E
H
I
R
G
L
A
A
E
L
L
A
------------
7
PsiBlast_PDB
72.16
29%
-82
- C1 -
-
4RJ0
1
?
B:
[63-474]
--------------------------------------------------------------------------------
E
-
A
A
A
T
E
A
T
L
L
Q
A
I
R
D
M
V
D
G
S
M
N
P
A
N
P
G
Y
I
G
H
M
D
P
M
P
A
T
M
A
I
L
G
D
L
V
A
A
A
V
N
N
N
M
L
S
L
E
M
S
P
S
F
S
R
L
E
T
L
L
L
R
A
I
A
G
L
F
G
L
G
-
E
Q
--------
A
G
-
G
V
L
T
S
G
G
S
L
A
N
L
Q
A
L
------
A
V
A
R
N
V
A
F
D
S
V
E
P
------
G
I
T
--
G
L
A
Q
R
P
V
-
I
F
A
S
E
A
A
H
T
S
L
Q
K
A
A
M
L
L
G
L
G
T
A
A
V
I
P
V
R
A
T
A
D
S
R
M
D
P
E
D
L
R
A
R
I
D
Q
A
R
G
A
G
Q
H
P
F
C
V
V
A
T
A
G
T
T
T
T
G
N
I
D
P
L
A
E
I
G
A
I
A
R
E
H
G
L
W
F
H
V
D
A
A
Y
G
G
A
L
V
F
S
E
R
H
R
W
R
L
A
G
I
E
Q
A
D
S
I
T
F
N
P
Q
K
W
L
Y
V
A
K
T
C
A
M
V
L
F
R
D
A
----------
G
---
V
-
L
E
R
-
A
-
F
---
R
I
P
-
A
P
N
M
---
R
A
T
----
D
G
F
I
N
L
G
E
I
G
V
Q
G
T
R
H
A
D
V
V
K
L
W
L
T
L
Q
H
I
G
Q
Q
G
Y
A
R
L
I
D
D
G
Y
R
L
A
E
R
V
V
E
G
V
R
Q
R
P
F
L
R
L
A
G
--
E
--
I
D
T
N
I
V
C
F
R
G
E
P
D
---
W
L
--------
P
-----
A
--
E
R
W
D
D
W
N
A
A
L
Q
A
L
L
L
R
E
----
G
K
I
F
L
S
L
P
V
Y
-
R
G
-
G
R
W
L
R
A
V
L
L
N
P
Y
T
T
D
A
V
I
D
A
M
F
K
Q
I
---------------------
9
PsiBlast_PDB
71.68
29%
-82
- C1 -
-
4RIT
8
?
B:
[63-463]
--------------------------------------------------------------------------------
E
-
A
A
A
T
E
A
T
L
L
Q
A
I
R
D
M
V
D
G
S
M
N
P
A
N
P
G
Y
I
G
H
M
D
P
M
P
A
T
M
A
I
L
G
D
L
V
A
A
A
V
N
N
N
M
L
S
L
E
M
S
P
S
F
S
R
L
E
T
L
L
L
R
A
I
A
G
L
F
G
L
G
-
E
Q
--------
A
G
-
G
V
L
T
S
G
G
S
L
A
N
L
Q
A
L
------
A
V
A
R
N
V
A
F
D
S
V
E
P
------
G
I
T
--
G
L
A
Q
R
P
V
-
I
F
A
S
E
A
A
H
T
S
L
Q
K
A
A
M
L
L
G
L
G
T
A
A
V
I
P
V
R
A
T
A
D
S
R
M
D
P
E
D
L
R
A
R
I
D
Q
A
R
G
A
G
Q
H
P
F
C
V
V
A
T
A
G
T
T
T
T
G
N
I
D
P
L
A
E
I
G
A
I
A
R
E
H
G
L
W
F
H
V
D
A
A
Y
G
G
A
L
V
F
S
E
R
H
R
W
R
L
A
G
I
E
Q
A
D
S
I
T
F
N
P
Q
K
W
L
Y
V
A
K
T
C
A
M
V
L
F
R
D
A
----------
G
---
V
-
L
E
R
-
A
-
F
---
R
I
P
-
A
--------------
G
F
I
N
L
G
E
I
G
V
Q
G
T
R
H
A
D
V
V
K
L
W
L
T
L
Q
H
I
G
Q
Q
G
Y
A
R
L
I
D
D
G
Y
R
L
A
E
R
V
V
E
G
V
R
Q
R
P
F
L
R
L
A
G
--
E
--
I
D
T
N
I
V
C
F
R
G
E
P
D
---
W
L
--------
P
-----
A
--
E
R
W
D
D
W
N
A
A
L
Q
A
L
L
L
R
E
----
G
K
I
F
L
S
L
P
V
Y
-
R
G
-
G
R
W
L
R
A
V
L
L
N
P
Y
T
T
--------------------------------
5
PsiBlast_PDB
71.64
29%
-83
- C1 -
-
4RIZ
-
?
A:
[63-474]
--------------------------------------------------------------------------------
E
-
A
A
A
T
E
A
T
L
L
Q
A
I
R
D
M
V
D
G
S
M
N
P
A
N
P
G
Y
I
G
H
M
D
P
M
P
A
T
M
A
I
L
G
D
L
V
A
A
A
V
N
N
N
M
L
S
L
E
M
S
P
S
F
S
R
L
E
T
L
L
L
R
A
I
A
G
L
F
G
L
G
-
E
Q
--------
A
G
-
G
V
L
T
S
G
G
S
L
A
N
L
Q
A
L
------
A
V
A
R
N
V
A
F
D
S
V
E
P
------
G
I
T
--
G
L
A
Q
R
P
V
-
I
F
A
S
E
A
A
H
T
S
L
Q
K
A
A
M
L
L
G
L
G
T
A
A
V
I
P
V
R
A
T
A
D
S
R
M
D
P
E
D
L
R
A
R
I
D
Q
A
R
G
A
G
Q
H
P
F
C
V
V
A
T
A
G
T
T
T
T
G
N
I
D
P
L
A
E
I
G
A
I
A
R
E
H
G
L
W
F
H
V
D
A
A
Y
G
G
A
L
V
F
S
E
R
H
R
W
R
L
A
G
I
E
Q
A
D
S
I
T
F
N
P
Q
K
W
L
Y
V
A
K
T
C
A
M
V
L
F
R
D
A
----------
G
---
V
-
L
E
R
-
A
-
F
---
R
I
P
-
A
P
Q
M
---
R
A
T
----
D
G
F
I
N
L
G
E
I
G
V
Q
G
T
R
H
A
D
V
V
K
L
W
L
T
L
Q
H
I
G
Q
Q
G
Y
A
R
L
I
D
D
G
Y
R
L
A
E
R
V
V
E
G
V
R
Q
R
P
F
L
R
L
A
G
--
E
--
I
D
T
N
I
V
C
F
R
G
E
P
D
---
W
L
--------
P
-----
A
--
E
R
W
D
D
W
N
A
A
L
Q
A
L
L
L
R
E
----
G
K
I
F
L
S
L
P
V
Y
-
R
G
-
G
R
W
L
R
A
V
L
L
N
P
Y
T
T
D
A
V
I
D
A
M
F
K
Q
I
---------------------
24
HHSearch
69.12
27%
-39
- C1 -
-
4RM1
-
?
C:
[4-480]
M
D
S
R
F
L
P
A
T
A
F
I
D
P
E
G
R
N
R
N
E
V
E
R
L
V
Q
Q
V
V
D
L
-
I
-
L
A
K
-
L
T
-----
G
-----
A
AE-
R
P
P
---
M
P
E
T
---
L
P
-
G
P
--
I
T
I
P
E
A
A
A
T
E
A
T
L
L
Q
A
I
-
R
D
M
V
D
G
S
M
N
P
A
N
P
G
Y
I
G
H
M
D
P
M
P
A
T
M
A
I
L
G
D
L
V
A
A
A
V
N
N
N
M
L
S
L
E
M
S
P
S
F
S
R
L
E
T
L
L
L
R
A
I
A
G
L
F
G
L
G
-
E
Q
--------
A
G
-
G
V
L
T
S
G
G
S
L
A
N
L
Q
A
L
A
V
A
R
N
V
A
F
D
S
V
-------
E
--
P
G
I
T
G
L
-----
A
Q
R
-
P
V
I
F
A
S
E
A
A
H
T
S
L
Q
K
A
A
M
L
L
G
L
G
T
A
A
V
I
P
V
R
A
T
A
D
S
R
M
D
P
E
D
L
R
A
R
I
D
Q
A
R
G
A
G
Q
H
P
F
C
V
V
A
T
A
G
T
T
T
T
G
N
I
D
P
L
A
E
I
G
A
I
A
R
E
H
G
L
W
F
H
V
D
A
A
Y
G
G
A
L
V
F
S
E
R
H
R
W
R
L
A
G
I
E
Q
A
D
S
I
T
F
N
P
Q
K
W
L
Y
V
A
K
T
C
A
M
V
L
F
R
D
A
----------
G
---
V
-
L
-
E
R
A
-
F
---
R
I
P
-
A
P
Q
M
---
R
A
-
D
----
G
F
I
N
L
G
E
I
G
V
Q
G
T
R
H
A
D
V
V
K
L
W
L
T
L
Q
H
I
G
Q
Q
G
Y
A
R
L
I
D
D
G
Y
R
L
A
E
R
V
V
E
G
V
R
Q
R
P
F
L
R
L
A
G
--
E
--
I
D
T
N
I
V
C
F
R
G
E
P
D
---
W
L
--------
P
-----
A
--
E
R
W
D
D
W
N
A
A
L
Q
A
L
L
L
R
E
----
G
K
I
F
L
S
L
P
V
Y
-
R
G
-
G
R
W
L
R
A
V
L
L
N
P
Y
T
T
D
A
V
I
D
A
M
F
K
Q
I
D
R
F
A
G
R
---------------
23
HHSearch
68.17
27%
-23
* C1 *
-
4RIT
8
?
B:
[8-483]
----
F
L
P
A
T
A
F
I
D
P
E
G
R
N
R
N
E
V
E
R
L
V
Q
Q
V
V
D
L
-
I
-
L
A
K
-
L
T
-----
G
-----
A
---
A
E
R
P
-
P
M
P
E
T
V
D
-
L
P
-
G
P
--
I
T
I
P
E
A
A
A
T
E
A
T
L
L
Q
A
I
R
D
-
M
V
D
G
S
M
N
P
A
N
P
G
Y
I
G
H
M
D
P
M
P
A
T
M
A
I
L
G
D
L
V
A
A
A
V
N
N
N
M
L
S
L
E
M
S
P
S
F
S
R
L
E
T
L
L
L
R
A
I
A
G
L
F
G
L
G
-
E
Q
--------
A
G
-
G
V
L
T
S
G
G
S
L
A
N
L
Q
A
L
A
V
A
R
N
V
A
F
D
S
V
-------
E
--
P
G
I
T
G
L
-----
A
Q
R
-
P
V
I
F
A
S
E
A
A
H
T
S
L
Q
K
A
A
M
L
L
G
L
G
T
A
A
V
I
P
V
R
A
T
A
D
S
R
M
D
P
E
D
L
R
A
R
I
D
Q
A
R
G
A
G
Q
H
P
F
C
V
V
A
T
A
G
T
T
T
T
G
N
I
D
P
L
A
E
I
G
A
I
A
R
E
H
G
L
W
F
H
V
D
A
A
Y
G
G
A
L
V
F
S
E
R
H
R
W
R
L
A
G
I
E
Q
A
D
S
I
T
F
N
P
Q
K
W
L
Y
V
A
K
T
C
A
M
V
L
F
R
D
A
----------
G
---
V
-
L
-
E
R
A
-
F
---
R
I
P
-
A
--------------
G
F
I
N
L
G
E
I
G
V
Q
G
T
R
H
A
D
V
V
K
L
W
L
T
L
Q
H
I
G
Q
Q
G
Y
A
R
L
I
D
D
G
Y
R
L
A
E
R
V
V
E
G
V
R
Q
R
P
F
L
R
L
A
G
--
E
--
I
D
T
N
I
V
C
F
R
G
E
P
D
---
W
L
--------
P
-----
A
--
E
R
W
D
D
W
N
A
A
L
Q
A
L
L
L
R
E
----
G
K
I
F
L
S
L
P
V
Y
-
R
G
-
G
R
W
L
R
A
V
L
L
N
P
Y
T
T
D
A
V
I
D
A
M
F
K
Q
I
D
R
F
A
G
R
E
R
G
------------
10
PsiBlast_PDB
68.05
29%
-82
- C1 -
-
4RLG
2
?
A:
[63-463]
--------------------------------------------------------------------------------
E
-
A
A
A
T
E
A
T
L
L
Q
A
I
R
D
M
V
D
G
S
M
N
P
A
N
P
G
Y
I
G
H
M
D
P
M
P
A
T
M
A
I
L
G
D
L
V
A
A
A
V
N
N
N
M
L
S
L
E
M
S
P
S
F
S
R
L
E
T
L
L
L
R
A
I
A
G
L
F
G
L
G
-
E
Q
--------
A
G
-
G
V
L
T
S
G
G
S
L
A
N
L
Q
A
L
------
A
V
A
R
N
V
A
F
D
S
V
E
P
------
G
I
T
--
G
L
A
Q
R
P
V
-
I
F
A
S
E
A
A
H
T
S
L
Q
K
A
A
M
L
L
G
L
G
T
A
A
V
I
P
V
R
A
T
A
D
S
R
M
D
P
E
D
L
R
A
R
I
D
Q
A
R
G
A
G
Q
H
P
F
C
V
V
A
T
A
G
T
T
T
T
G
N
I
D
P
L
A
E
I
G
A
I
A
R
E
H
G
L
W
F
H
V
D
A
A
Y
G
G
A
L
V
F
S
E
R
H
R
W
R
L
A
G
I
E
Q
A
D
S
I
T
F
N
P
Q
K
W
L
Y
V
A
K
T
C
A
M
V
L
F
R
D
A
----------
G
---
V
-
L
E
R
-
A
-
F
---
R
I
P
-
A
-
Y
M
---
R
------
D
G
F
I
N
L
G
E
I
G
V
Q
G
T
R
H
A
D
V
V
K
L
W
L
T
L
Q
H
I
G
Q
Q
G
Y
A
R
L
I
D
D
G
Y
R
L
A
E
R
V
V
E
G
V
R
Q
R
P
F
L
R
L
A
G
--
E
--
I
D
T
N
I
V
C
F
R
G
E
P
D
---
W
L
--------
P
-----
A
--
E
R
W
D
D
W
N
A
A
L
Q
A
L
L
L
R
E
----
G
K
I
F
L
S
L
P
V
Y
-
R
G
-
G
R
W
L
R
A
V
L
L
N
P
Y
T
T
--------------------------------
30
HHSearch
67.38
21%
-14
- C1 -
-
1JS3
3
DDC_PIG
A:
[3-476]
------------------
A
S
D
F
R
R
R
G
K
E
M
V
D
Y
-
M
-
A
D
Y
-
L
E
G
IE--
G
-----
R
---
Q
V
Y
P
D
V
Q
P
G
Y
L
R
P
L
I
-
P
---
A
T
A
P
Q
E
P
D
T
F
E
D
I
L
Q
D
V
E
K
I
I
M
P
G
V
T
H
W
H
S
P
Y
F
F
A
Y
F
P
T
A
S
S
Y
P
A
M
L
A
D
M
L
C
G
A
I
G
C
I
G
F
S
W
A
A
S
P
A
C
T
E
L
E
T
V
M
M
D
W
L
G
K
M
L
Q
L
P
-
E
A
FLAGEAGE
G
G
-
G
V
I
Q
G
S
A
S
E
A
T
L
V
A
L
L
A
A
R
T
K
V
V
R
R
L
---------
Q
A
A
S
P
G
L
T
Q
G
A
V
L
E
K
-
L
V
A
Y
A
S
D
Q
A
H
S
S
V
E
R
A
G
L
I
G
G
V
K
---
L
K
A
I
P
S
D
G
K
F
A
M
R
A
S
A
L
Q
E
A
L
E
R
D
K
A
A
G
L
I
P
F
F
V
V
A
T
L
G
T
T
S
C
C
S
F
D
N
L
L
E
V
G
P
I
C
H
E
E
D
I
W
L
H
V
D
A
A
Y
A
G
S
A
F
I
C
P
E
F
R
H
L
L
N
G
V
E
F
A
D
S
F
N
F
N
P
H
K
W
L
L
V
N
F
D
C
S
A
M
W
V
K
R
R
----------
T
---
D
-
L
-
T
G
A
-
F
---
K
----------------
S
G
L
I
T
D
Y
R
H
W
Q
L
P
L
G
R
R
F
R
S
L
K
M
W
F
V
F
R
M
Y
G
V
K
G
L
Q
A
Y
I
R
K
H
V
Q
L
S
H
E
F
E
A
F
V
L
Q
D
P
R
F
E
V
C
A
--
E
--
V
T
L
G
L
V
C
F
R
L
K
G
S
---
D
----------------------
G
L
N
E
A
L
L
E
R
I
N
S
A
----
R
K
I
H
L
V
P
C
R
L
-
R
G
-
Q
F
V
L
R
F
A
I
C
S
R
K
V
E
S
G
H
V
R
L
A
W
E
H
I
R
G
L
A
A
E
L
L
A
------------
8
PsiBlast_PDB
67.28
27%
-40
- C1 -
-
2OKK
2
DCE2_HUMAN
A:
[80-491]
-------------------------------------------------------------------------------------------------
L
K
Y
A
I
K
T
G
H
P
R
Y
F
N
Q
L
S
T
G
L
D
M
V
G
L
A
A
D
W
L
T
S
T
A
N
T
N
M
F
T
Y
E
I
A
P
V
F
V
L
L
E
Y
V
T
L
K
K
M
R
E
I
I
G
W
P
-
G
G
--------
S
G
D
G
I
F
S
P
G
G
A
I
S
N
M
Y
A
M
M
I
A
R
F
K
M
F
P
E
--
V
K
E
K
G
-------------
M
A
A
L
P
R
L
I
A
F
T
S
E
H
S
H
F
S
L
K
K
G
A
A
A
L
G
I
G
T
D
S
V
I
L
I
K
C
D
E
R
G
K
M
I
P
S
D
L
E
R
R
I
L
E
A
K
Q
K
G
F
V
P
F
L
V
S
A
T
A
G
T
T
V
Y
G
A
F
D
P
L
L
A
V
A
D
I
C
K
K
Y
K
I
W
M
H
V
D
A
A
W
G
G
G
L
L
M
S
R
K
H
K
W
K
L
S
G
V
E
R
A
N
S
V
T
W
N
P
H
K
M
M
G
V
P
L
Q
C
S
A
L
L
V
R
E
E
----------
G
L
M
Q
N
-
C
-
N
-
Q
-
M
---
H
--------------
D
L
S
Y
D
T
G
D
---
K
A
L
Q
C
G
R
H
V
D
V
F
K
L
W
L
M
W
R
A
K
G
T
T
G
F
E
A
H
V
D
K
C
L
E
L
A
E
Y
L
Y
N
I
I
K
N
R
E
G
Y
E
M
V
F
--
D
GK
P
Q
H
T
N
V
C
F
W
Y
I
P
P
---
S
L
--------
R
-----
T
LE
E
R
M
S
R
L
S
K
-
V
A
P
V
I
K
A
R
M
M
E
Y
G
T
T
M
V
S
Y
Q
P
L
-
G
D
K
V
N
F
F
R
M
V
I
S
N
P
A
A
T
H
Q
D
I
D
F
L
I
E
E
I
---------------------
31
HHSearch
66.41
28%
-5
- C1 -
-
2JIS
2
CSAD_HUMAN
A:
[33-514]
---------------
A
G
D
P
V
A
V
E
A
L
L
R
A
V
F
G
V
-
V
-
V
D
E
A
I
Q
KGTSV
S
-----
Q
---
K
V
C
E
W
K
E
P
E
E
L
K
Q
L
L
-
D
---
L
E
L
R
S
Q
G
E
S
Q
K
Q
I
L
E
R
C
R
A
V
-
I
R
Y
S
V
K
T
G
H
P
R
F
F
N
Q
L
F
S
G
L
D
P
H
A
L
A
G
R
I
I
T
E
S
L
N
T
S
Q
Y
T
Y
E
I
A
P
V
F
V
L
M
E
E
E
V
L
R
K
L
R
A
L
V
G
W
S
--
S
--------
G
D
-
G
I
F
C
P
G
G
S
I
S
N
M
Y
A
V
N
L
A
R
Y
Q
R
Y
P
D
C
-----------
K
Q
R
G
L
R
--
T
L
P
P
--
L
A
L
F
T
S
K
E
C
H
Y
S
I
Q
K
G
A
A
F
L
G
L
G
T
D
S
V
R
V
V
K
A
D
E
R
G
K
M
V
P
E
D
L
E
R
Q
I
G
M
A
E
A
E
G
A
V
P
F
L
V
S
A
T
S
G
T
T
V
L
G
A
F
D
P
L
E
A
I
A
D
V
C
Q
R
H
G
L
W
L
H
V
D
A
A
W
G
G
S
V
L
L
S
Q
T
H
R
H
L
L
D
G
I
Q
R
A
D
S
V
A
W
N
P
H
K
L
L
A
A
G
L
Q
C
S
A
L
L
L
Q
D
T
S---------
N
---
L
-
L
-
K
-
R
-
C
H--
G
S
-------------
K
F
Y
D
V
A
L
D
T
G
D
K
V
V
Q
C
G
R
R
V
D
C
L
K
L
W
L
M
W
K
A
Q
G
D
Q
G
L
E
R
R
I
D
Q
A
F
V
L
A
R
Y
L
V
E
E
M
K
K
R
E
G
F
E
L
V
M
--
E
--
P
E
F
V
N
V
C
F
W
F
V
P
P
---
S
L
RGKQESPD
Y
-----
H
--
E
R
L
S
K
V
A
P
V
L
K
E
R
M
V
K
E
----
G
S
M
M
I
G
Y
Q
P
H
-
G
T
R
G
N
F
F
R
V
V
V
A
N
S
A
L
T
C
A
D
M
D
F
L
L
N
E
L
E
R
L
G
Q
D
---------------
11
PsiBlast_PDB
64.65
24%
-29
- C1 -
-
3VP6
2
DCE1_HUMAN
A:
[87-498]
-------------------------------------------------------------------------------------------------
L
K
Y
G
V
R
T
G
H
P
R
F
F
N
Q
L
S
T
G
L
D
I
I
G
L
A
G
E
W
L
T
S
T
A
N
T
N
M
F
T
Y
E
I
A
P
V
F
V
L
M
E
Q
I
T
L
K
K
M
R
E
I
V
G
W
S
-
S
K
--------
D
G
D
G
I
F
S
P
G
G
A
I
S
N
M
Y
S
I
M
A
A
R
-------------
Y
K
Y
F
P
E
V
K
T
K
G
--
M
A
A
V
P
K
L
V
L
F
T
S
E
Q
S
H
Y
S
I
K
K
A
G
A
A
L
G
F
G
T
D
N
V
I
L
I
K
C
N
E
R
G
K
I
I
P
A
D
F
E
A
K
I
L
E
A
K
Q
K
G
Y
V
P
F
Y
V
N
A
T
A
G
T
T
V
Y
G
A
F
D
P
I
Q
E
I
A
D
I
C
E
K
Y
N
L
W
L
H
V
D
A
A
W
G
G
G
L
L
M
S
R
K
H
R
H
K
L
N
G
I
E
R
A
N
S
V
T
W
N
P
H
K
M
M
G
V
L
L
Q
C
S
A
I
L
V
K
E
K
G
I
L
Q
G
C
NQMH
A
---
S
-
Y
-
L
-
F
-
Q
QDK
H
Y
D
-
V
S
Y
---------------
D
T
G
D
K
A
I
Q
C
G
R
H
V
D
I
F
K
F
W
L
M
W
K
A
K
G
T
V
G
F
E
N
Q
I
N
K
C
L
E
L
A
E
Y
L
Y
A
K
I
K
N
R
E
E
F
E
M
V
F
NG
E
--
P
E
H
T
N
V
C
F
W
Y
I
P
Q
SLR
G
V
--------
P
D
S
P
Q
R
R
--
E
K
L
H
K
V
A
P
K
I
K
A
L
M
M
E
S
----
G
T
T
M
V
G
Y
Q
P
Q
-
G
D
K
A
N
F
F
R
M
V
I
S
N
P
A
A
T
Q
S
D
I
D
F
L
I
E
E
I
---------------------
12
PsiBlast_PDB
64.39
25%
-25
- C1 -
-
2OKJ
3
DCE1_HUMAN
A:
[84-495]
-------------------------------------------------------------------------------------------------
L
K
Y
G
V
R
T
G
H
P
R
F
F
N
Q
L
S
T
G
L
D
I
I
G
L
A
G
E
W
L
T
S
T
A
N
T
N
M
F
T
Y
E
I
A
P
V
F
V
L
M
E
Q
I
T
L
K
K
M
R
E
I
V
G
W
S
-
S
K
--------
D
G
D
G
I
F
S
P
G
G
A
I
S
N
M
Y
S
I
M
A
A
R
-------------
Y
K
Y
F
P
E
V
K
T
K
G
--
M
A
A
V
P
K
L
V
L
F
T
S
E
Q
S
H
Y
S
I
K
K
A
G
A
A
L
G
F
G
T
D
N
V
I
L
I
K
C
N
E
R
G
K
I
I
P
A
D
F
E
A
K
I
L
E
A
K
Q
K
G
Y
V
P
F
Y
V
N
A
T
A
G
T
T
V
Y
G
A
F
D
P
I
Q
E
I
A
D
I
C
E
K
Y
N
L
W
L
H
V
D
A
A
W
G
G
G
L
L
M
S
R
K
H
R
H
K
L
N
G
I
E
R
A
N
S
V
T
W
N
P
H
K
M
M
G
V
L
L
Q
C
S
A
I
L
V
K
E
K
----------
G
---
I
-
L
-
Q
-
G
-
C
---
N
Q
M
C
A
G
Y
L
FQP
D
K
Q
Y
D
V
S
Y
D
T
G
D
---
K
A
I
Q
C
G
R
H
V
D
I
F
K
F
W
L
M
W
K
A
K
G
T
V
G
F
E
N
Q
I
N
K
C
L
E
L
A
E
Y
L
Y
A
K
I
K
N
R
E
E
F
E
M
V
F
NG
E
--
P
E
H
T
N
V
C
F
W
Y
I
P
Q
SLR
G
V
--------
P
D
S
P
Q
R
R
--
E
K
L
H
K
V
A
P
K
I
K
A
L
M
M
E
S
----
G
T
T
M
V
G
Y
Q
P
Q
-
G
D
K
A
N
F
F
R
M
V
I
S
N
P
A
A
T
Q
S
D
I
D
F
L
I
E
E
I
---------------------
32
HHSearch
63.52
28%
-3
- C1 -
-
2JIS
2
CSAD_HUMAN
B:
[33-514]
---------------
A
G
D
P
V
A
V
E
A
L
L
R
A
V
F
G
V
-
V
-
V
D
E
A
I
Q
KGTSV
S
-----
Q
---
K
V
C
E
W
K
E
P
E
E
L
K
Q
L
L
-
D
---
L
E
L
R
S
Q
G
E
S
Q
K
Q
I
L
E
R
C
R
A
V
-
I
R
Y
S
V
K
T
G
H
P
R
F
F
N
Q
L
F
S
G
L
D
P
H
A
L
A
G
R
I
I
T
E
S
L
N
T
S
Q
Y
T
Y
E
I
A
P
V
F
V
L
M
E
E
E
V
L
R
K
L
R
A
L
V
G
W
S
--
S
--------
G
D
-
G
I
F
C
P
G
G
S
I
S
N
M
Y
A
V
N
L
A
R
Y
Q
R
Y
P
D
C
-----------
K
Q
R
G
L
R
--
T
L
P
P
--
L
A
L
F
T
S
K
E
C
H
Y
S
I
Q
K
G
A
A
F
L
G
L
G
T
D
S
V
R
V
V
K
A
D
E
R
G
K
M
V
P
E
D
L
E
R
Q
I
G
M
A
E
A
E
G
A
V
P
F
L
V
S
A
T
S
G
T
T
V
L
G
A
F
D
P
L
E
A
I
A
D
V
C
Q
R
H
G
L
W
L
H
V
D
A
A
W
G
G
S
V
L
L
S
Q
T
H
R
H
L
L
D
G
I
Q
R
A
D
S
V
A
W
N
P
H
K
L
L
A
A
G
L
Q
C
S
A
L
L
L
Q
D
T
S---------
N
---
L
-
L
-
K
-
R
-
C
H
--
G
S
Q
-
A
S
Y
L
---
F
Q
Q
D
K
F
Y
D
V
A
L
D
T
G
D
K
V
V
Q
C
G
R
R
V
D
C
L
K
L
W
L
M
W
K
A
Q
G
D
Q
G
L
E
R
R
I
D
Q
A
F
V
L
A
R
Y
L
V
E
E
M
K
K
R
E
G
F
E
L
V
M
--
E
--
P
E
F
V
N
V
C
F
W
F
V
P
P
---
S
L
RGKQESPD
Y
-----
H
--
E
R
L
S
K
V
A
P
V
L
K
E
R
M
V
K
E
----
G
S
M
M
I
G
Y
Q
P
H
-
G
T
R
G
N
F
F
R
V
V
V
A
N
S
A
L
T
C
A
D
M
D
F
L
L
N
E
L
E
R
L
G
Q
D
---------------
27
HHSearch
62.13
23%
3
- C1 -
-
2OKJ
3
DCE1_HUMAN
B:
[13-503]
-------------
P
A
K
N
G
E
E
Q
T
V
Q
F
L
L
E
V
V
D
I
-
L
-
L
N
Y
-
V
R
-----
K
TFDRS
T
---
K
V
L
D
F
H
H
P
H
Q
L
L
E
G
M
-
E
G
FN
L
E
L
S
D
H
P
E
S
L
E
Q
I
L
V
D
C
R
D
T
L
-
K
Y
G
V
R
T
G
H
P
R
F
F
N
Q
L
S
T
G
L
D
I
I
G
L
A
G
E
W
L
T
S
T
A
N
T
N
M
F
T
Y
E
I
A
P
V
F
V
L
M
E
Q
I
T
L
K
K
M
R
E
I
V
G
W
S
S
K
D
--------
G
D
-
G
I
F
S
P
G
G
A
I
S
N
M
Y
S
I
M
A
A
R
Y
K
Y
F
P
E
V
-----------
K
T
K
G
M
A
--
A
V
P
K
--
L
V
L
F
T
S
E
Q
S
H
Y
S
I
K
K
A
G
A
A
L
G
F
G
T
D
N
V
I
L
I
K
C
N
E
R
G
K
I
I
P
A
D
F
E
A
K
I
L
E
A
K
Q
K
G
Y
V
P
F
Y
V
N
A
T
A
G
T
T
V
Y
G
A
F
D
P
I
Q
E
I
A
D
I
C
E
K
Y
N
L
W
L
H
V
D
A
A
W
G
G
G
L
L
M
S
R
K
H
R
H
K
L
N
G
I
E
R
A
N
S
V
T
W
N
P
H
K
M
M
G
V
L
L
Q
C
S
A
I
L
V
K
E
K
----------
G
---
I
-
L
-
Q
-
G
C
N
---
Q
M
C
-
A
G
Y
L
---
F
Q
P
D
K
Q
Y
D
V
S
Y
D
T
G
D
K
A
I
Q
C
G
R
H
V
D
I
F
K
F
W
L
M
W
K
A
K
G
T
V
G
F
E
N
Q
I
N
K
C
L
E
L
A
E
Y
L
Y
A
K
I
K
N
R
E
E
F
E
M
V
F
NG
E
--
P
E
H
T
N
V
C
F
W
Y
I
P
Q
---
S
L
RGVPDSPQ
R
-----
R
--
E
K
L
H
K
V
A
P
K
I
K
A
L
M
M
E
S
----
G
T
T
M
V
G
Y
Q
P
Q
G
D
K
-
A
N
F
F
R
M
V
I
S
N
P
A
A
T
Q
S
D
I
D
F
L
I
E
E
I
E
R
L
G
Q
D
L
H
-------------
29
HHSearch
62.05
26%
8
- C1 -
-
4OBU
2
?
E:
[16-488]
------------
T
E
Y
I
L
N
S
T
Q
L
E
E
A
I
K
S
F
V
H
D
-
F
-
C
A
E
-
K
H
-----
E
-----
I
HDQ
P
V
V
V
E
A
K
E
H
Q
E
D
K
I
K
--
Q
--
I
K
I
P
E
K
G
R
P
V
N
E
V
V
S
E
M
M
N
E
V
Y
R
Y
R
G
D
A
N
H
P
R
F
F
S
F
V
P
G
P
A
S
S
V
S
W
L
G
D
I
M
T
S
A
Y
N
I
H
A
G
G
S
K
L
A
P
M
V
N
C
I
E
Q
E
V
L
K
W
L
A
K
Q
V
G
F
T
-
E
N
--------
P
G
-
G
V
F
V
S
G
G
S
M
A
N
I
T
A
L
T
A
A
R
D
N
K
L
T
D
I
--------------
N
-----
L
-
H
L
-
G
T
A
Y
I
S
D
Q
T
H
S
S
V
A
K
G
L
R
I
I
G
I
T
D
S
R
I
R
R
I
P
T
N
S
H
F
Q
M
D
T
T
K
L
E
E
A
I
E
T
D
K
K
S
G
Y
I
P
F
V
V
I
G
T
A
G
T
T
N
T
G
S
I
D
P
L
T
E
I
S
A
L
C
K
K
H
D
M
W
F
H
I
D
G
A
Y
G
A
S
V
L
L
S
P
K
Y
K
S
L
L
T
G
T
G
L
A
D
S
I
S
W
D
A
H
K
W
L
F
Q
T
Y
G
C
A
M
V
L
V
K
D
I
----------
R
---
N
-
L
-
F
H
S
-
F
---
H
V
N
-
P
E
Y
L
-----------------
D
I
G
M
E
L
T
R
P
A
R
G
L
K
L
W
L
T
L
Q
V
L
G
S
D
L
I
G
S
A
I
E
H
G
F
Q
L
A
V
W
A
E
E
A
L
N
P
K
K
D
W
E
I
V
S
--
P
--
A
Q
M
A
M
I
N
F
R
Y
A
P
K
---
D
L
--------
T
-----
K
--
E
E
Q
D
I
L
N
E
K
I
S
H
R
I
L
E
S
----
G
Y
A
A
I
F
T
T
V
L
-
N
G
-
K
T
V
L
R
I
C
A
I
H
P
E
A
T
Q
E
D
M
Q
H
T
I
D
L
L
D
Q
Y
G
R
E
I
Y
T
E
M
K
---------