@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U1G7: (2017-12-20 )
MPCHKEPIKKELVTLNYRNDIRNVAIIAHVDHGKTTLVDELLKQSDTLDAHTQLQERAMDSNALEKERGITILAKNTAVDYKGIRVNIMDTPGHADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKALEQHITPIVVVNKIDKPSARPEHVVDEVLELFIELGADDDQLDFPVIYASALNGTSSLSDDPADQEPTMAPIFDTIIEKIPAPVDNSDEPLQFQVSLLDYNDYVGRIGIGRVFRGTIKVGDQVALIKLDGTVKKFRVTKLFGFFGLKRLEIQEAKAGDLIAVSGMEDIFVGETVTPVDHQDALPILHIDEPTLQMTFLVNNSPFAGREGKFVTARKIEERLMAELQTDVSLRVEPTNSPDAWTVSGRGELHLSILIENMRREGYELQVSRPEVIEKEIDGVKCEPFERVQIDTPEEYMGSVIESLSLRKGEMQDMVHTGNGQIRLTFLTPARGLIGYSTEFLSMTRGYGIMNHTFDQYLPMLPGQIGGRHQGALVSIDTGKATTYSIMSIEERGTVFVEPGTEVYEGMIIGENSRDNDLTVNITKAKQMTNVRSATKDQTSVIKKPKQLTLEESLEFLNDDEYCEVTPESIRLRKQILEKNAREKASKKKK
Atome Classification :
(20 SA)
.........10........20........30........40........50-.-------.--......60........70........80.-------.-----......90........100.......110.......120.......130.......140.......150-----------.-----------......160-----------------------....----.--------------------------------.-----------------------------------------------------------------------.--------------------------------------------------------------.-------------------------------------------170----------------------------------------------------------.--------------------------.------------.------------..-----....180.......190----------------------------------------------------------------------------------.----------------------------------------------------------------.--------------------------------------------------------------------.-----------------------------.--------------------------..-.-200........210.....---------------------------.--------------------.220.......230.-..-....240.......250.......260------.---------------......270.......280.......290..----.....300.-.-......310-.---.--.------.....-.-320........330.......340.......350.......360......---.370.......380.......390..--.-....400.......--410----------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------.---------------------------------------------------------.......420.......430.......440-.......450-.......460...-....470.......480.......--490.......500......----------------.510.......520.......530.......540.-......550.......560.......570.......580.......590.......600.......610.......620.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPC
H
K
E
P
I
K
K
E
L
V
T
L
NYRNDIR
N
V
A
I
I
A
H
VDHG
K
T
T
L
V
D
E
L
L
KQSDT
L
D
A
H
-
T
-------
Q
--
L
Q
E
RAMDSNALEKER
G
I
T
I
L
AKN
T
A
VDYK-------
G
-----
I
R
V
N
I
M
DTPGHADF
G
G
E
V
E
R
I
M
K
MVD
G
V
V
L
V
V
DAYEGTM
P
Q
T
R
F
V
L
K
K
A
L
E
QHI
T
P
I
V
V
V
NKIDKPSAR-----------
P
-----------
E
H
V
V
D
E
V
L
------------------------
E
L
F
I
----
E
--------------------------------L-----------------------------------------------------------------------G--------------------------------------------------------------A-------------------------------------------D------------------------------------------------------------D--------------------------D------------Q------------LD-----F
P
V
I
Y
A
SALNGTSSLSD----------------------------------------------------------------------------------D----------------------------------------------------------------P--------------------------------------------------------------------A-----------------------------D--------------------------QE-P-T-MA
P
I
F
D
T
I
I
E
KIPAPVD---------------------------N--------------------SDE
P
L
Q
F
Q
V
S
L
LDYN-DY-VGRIGI
G
R
V
F
R
G
T
I
KVG
D
Q
V
A
L
I
K
LDG------T---------------
V
K
K
F
R
V
T
K
L
F
G
F
FG
L
K
R
L
E
I
QEAKAG
D
L
I
A
V----SGMEDI-FV-G-ETVTPVD---H---Q--D------AL
P
I
L
-
H
-I-DEP
T
L
Q
M
T
F
L
VNNSPFAGREG
K
F
V
T
A
R
K
I
E
E
R
L
M
A
E
L
QTD
V
S
L
R
V
EPT---NSPD
A
W
T
VSGR
G
E
L
H
L
S
I
L
I
E
N
M
R
RE--G-
Y
E
L
QVS
R
P
E
V
I
E
K
E--I------------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------------------------------------------------------------------------------------G---------------------------------------------------------VKCEPF
E
R
V
QID
T
P
E
E
Y
M
G
S
V
I
E
S
L
SLRK
G
-
E
M
Q
D
M
V
HTGN-G
Q
I
R
L
T
F
LTPARG-LIGY
S
T
E
F
L
S
M
T
RGYGI
M
N
H
T
F
D
Q
--
Y
LPMLPGQIGGRHQ
G
A
L
V
S
----------------
I
DTGK
A
T
T
Y
S
I
M
S
I
EER
G
T
V
F
VEPGTE
V
Y
E
G
M
I
IG-ENSRDN
D
L
T
V
N
I
T
K
A
K
Q
M
T
N
V
R
SATK
D
Q
T
S
V
IKKPKQL
T
L
E
E
S
L
E
F
LNDDEYCEV
T
P
E
S
I
R
L
R
K
Q
I
L
E
K
N
A
R
E
K
ASKKKK
4
PsiBlast_PDB
87.67
53%
-81
- C1 -
-
4ZCI
2
TYPA_ECOLI
A:
[39-635]
--------------------
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
-------
D
-----
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
------------------------
D
L
F
V
----
N
--------------------------------
L
-----------------------------------------------------------------------
D
--------------------------------------------------------------
A
-------------------------------------------
T
------------------------------------------------------------
D
--------------------------
E
------------
Q
------------
L
D
-----
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
------------------------------------------------------------------------------------
D
----------------------------------------------------------------
H
--------------------------------------------------------------------
E
-----------------------------
D
--------------------------
M
A
-
E
-
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
-
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
L
G
E
L
-
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
---
V
--
E
------
A
L
P
A
L
-
S
-
V
-
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
---
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
E
--
I
------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------
R
K
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----
119
HHSearch
87.09
53%
-81
- C1 -
-
4ZCI
2
TYPA_ECOLI
B:
[35-635]
----------------
M
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
-------
D
-----
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
------------------------
D
L
F
V
----
N
--------------------------------
L
-----------------------------------------------------------------------
D
--------------------------------------------------------------
A
-------------------------------------------
T
------------------------------------------------------------
D
--------------------------
E
------------
Q
------------
L
D
-----
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
D
H
----------------------------------------------------------------------------------
E
----------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------------------------
M
A
-
E
-
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
-
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
L
G
E
L
-
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
---
V
--
E
------
A
L
P
A
L
-
S
-
V
-
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
---
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
E
--
I
------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------
R
K
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----
23
PsiBlast_CBE
86.57
53%
-83
- C1 -
-
4ZCI
2
TYPA_ECOLI
B:
[39-635]
--------------------
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
-------
D
-----
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
------------------------
D
L
F
V
----
N
--------------------------------
L
-----------------------------------------------------------------------
D
--------------------------------------------------------------
A
-------------------------------------------
T
------------------------------------------------------------
D
--------------------------
E
------------
Q
------------
L
D
-----
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
------------------------------------------------------------------------------------
D
----------------------------------------------------------------
H
--------------------------------------------------------------------
E
-----------------------------
D
--------------------------
M
A
-
E
-
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
-
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
L
G
E
L
-
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
---
V
--
E
------
A
L
P
A
L
-
S
-
V
-
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
---
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
E
--
I
------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------
R
K
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----
5
PsiBlast_PDB
86.19
53%
-81
- C1 -
-
4ZCL
3
TYPA_ECOLI
A:
[39-635]
--------------------
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
-------
D
-----
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
------------------------
D
L
F
V
----
N
--------------------------------
L
-----------------------------------------------------------------------
D
--------------------------------------------------------------
A
-------------------------------------------
T
------------------------------------------------------------
D
--------------------------
E
------------
Q
------------
L
D
-----
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
------------------------------------------------------------------------------------
D
----------------------------------------------------------------
H
--------------------------------------------------------------------
E
-----------------------------
D
--------------------------
M
A
-
E
-
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
-
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
L
G
E
L
-
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
---
V
--
E
------
A
L
P
A
L
-
S
-
V
-
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
---
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
E
--
I
------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------
R
K
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----
22
PsiBlast_CBE
86.04
53%
-79
- C1 -
-
4ZCL
3
TYPA_ECOLI
B:
[39-635]
--------------------
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
-------
D
-----
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
------------------------
D
L
F
V
----
N
--------------------------------
L
-----------------------------------------------------------------------
D
--------------------------------------------------------------
A
-------------------------------------------
T
------------------------------------------------------------
D
--------------------------
E
------------
Q
------------
L
D
-----
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
------------------------------------------------------------------------------------
D
----------------------------------------------------------------
H
--------------------------------------------------------------------
E
-----------------------------
D
--------------------------
M
A
-
E
-
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
-
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
L
G
E
L
-
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
---
V
--
E
------
A
L
P
A
L
-
S
-
V
-
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
---
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
E
--
I
------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------
R
K
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----
1
PsiBlast_PDB
85.36
53%
-79
- C1 -
-
4ZCM
3
TYPA_ECOLI
A:
[39-635]
--------------------
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
-------
D
-----
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
------------------------
D
L
F
V
----
N
--------------------------------
L
-----------------------------------------------------------------------
D
--------------------------------------------------------------
A
-------------------------------------------
T
------------------------------------------------------------
D
--------------------------
E
------------
Q
------------
L
D
-----
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
------------------------------------------------------------------------------------
D
----------------------------------------------------------------
H
--------------------------------------------------------------------
E
-----------------------------
D
--------------------------
M
A
-
E
-
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
-
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
L
G
E
L
-
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
---
V
--
E
------
A
L
P
A
L
-
S
-
V
-
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
---
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
E
--
I
------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------
R
K
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----
21
PsiBlast_CBE
84.96
53%
-78
- C1 -
-
4ZCM
3
TYPA_ECOLI
B:
[39-635]
--------------------
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
-------
D
-----
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
------------------------
D
L
F
V
----
N
--------------------------------
L
-----------------------------------------------------------------------
D
--------------------------------------------------------------
A
-------------------------------------------
T
------------------------------------------------------------
D
--------------------------
E
------------
Q
------------
L
D
-----
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
------------------------------------------------------------------------------------
D
----------------------------------------------------------------
H
--------------------------------------------------------------------
E
-----------------------------
D
--------------------------
M
A
-
E
-
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
-
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
L
G
E
L
-
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
---
V
--
E
------
A
L
P
A
L
-
S
-
V
-
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
---
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
E
--
I
------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------
R
K
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----
2
PsiBlast_PDB
78.00
53%
-68
- C5 -
-
5A9W
1
TYPA_ECOLI
A:
[5-604]
--------------------
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
T
--------------------------
L
E
K
E
R
G
I
T
I
L
A
K
N
T
A
---
N
-------
D
-----
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
--
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
------------------------
D
L
F
V
----
N
--------------------------------
L
-----------------------------------------------------------------------
D
--------------------------------------------------------------
A
-------------------------------------------
T
------------------------------------------------------------
D
--------------------------
E
------------
Q
------------
L
D
-----
F
P
I
V
Y
A
S
A
L
N
---
G
L
------------------------------------------------------------------------------------
D
----------------------------------------------------------------
H
--------------------------------------------------------------------
E
-----------------------------
D
--------------------------
M
A
-
E
-
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
-
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
---
E
L
-
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
---
V
--
E
------
A
L
P
A
L
-
S
-
V
-
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
---
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
E
--
I
------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------
R
K
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
G
K
K
L
T
N
----------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
R
A
P
-
3
PsiBlast_PDB
77.27
53%
-62
- C5 -
-
5A9X
1
TYPA_ECOLI
A:
[5-602]
--------------------
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
-----------------------------
K
E
R
G
I
T
I
L
A
K
N
T
A
-----------
D
-----
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
------------------------
D
L
F
V
----
N
--------------------------------
L
-----------------------------------------------------------------------
D
--------------------------------------------------------------
A
-------------------------------------------
T
------------------------------------------------------------
D
--------------------------
E
------------
Q
------------
L
D
-----
F
P
I
V
Y
A
S
A
L
N
---
G
L
------------------------------------------------------------------------------------
D
----------------------------------------------------------------
H
--------------------------------------------------------------------
E
-----------------------------
D
--------------------------
M
A
-
E
-
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
-
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
---
E
L
-
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
---
V
--
E
------
A
L
P
A
L
-
S
-
V
-
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
---
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
E
--
I
------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------
R
K
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
-----------------
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
R
---
134
HHSearch
63.30
33%
-
- C1 -
-
1ZN0
-
EFG_THET8
B:
[8-682]
----------------
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
A
V
------------------------------------
T
T
C
F
W
K
-------
D
-----
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
-----------
L
-----------
W
L
V
I
R
T
M
Q
------------------------
E
R
L
G
----
A
--------------------------------
R
PVVM
Q
L
P
I
G
REDTFSGIIDVLRM
K
A
Y
T
Y
GNDL---------------------------------------
G
T
D
I
R
E
I
P
IPEEY
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
-------------------
P
-------------------------------------------
T
------------------------------------------------------------
E
--------------------------
E
------------
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
-----
T
P
V
F
L
G
S
A
L
K
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
IP
P
I
K
G
T
T
PEG
E
V
V
E
IHP---------
D
--------------------
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
-
P
Y
-
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
-
T
K
G
-----------------------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
-
I
T
-
G
-
D
T
L
V
G
E
D
---
A
---
P
R-
V
------
I
L
E
S
I
-
E
-
V
-
P
E
P
V
I
D
V
----
A
I
E
P
K
T
K
A
D
--
Q
E
---
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
---
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F-
K
-
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T-
I
------------------------------------------------------------------------------------------------------
T
K
P
V
D
V
E
G
K
F
I
R
QTGG
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
RGSG
F
E
F
V
N
AIVGGVIPKEY
I
P
A
V
Q
K
G
I
E
E
A
M
QSGPLIGFPV
V
D
I
K
V
T
LY
D
G
S
Y
A
EVDSS
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
-----------------------------------------------
P
---------------------------------------------------------
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
-
Q
I
L
G
M
E
P
R
G
--
N
A
Q
V
I
R
A
F
V
P
L
A
E
-
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
--
Y
Q
E
V
P
K
Q
------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
62.74
33%
3
- C1 -
-
2BM0
1
?
A:
[6-682]
--------------
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
-
A
---------------------------
T
I
T
A
A
V
T
T
C
F
W
K
-------
D
-----
H
R
I
N
I
I
D
A
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
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A
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V
V
F
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S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
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A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
-----------
L
-----------
W
L
V
I
R
T
M
Q
------------------------
E
R
L
G
----
A
RPVVM
Q
L
P
I
G
REDTFSGIIDVLRM
K
A
Y
T
Y
GND
L
-----------------------------------------------------------------------
G
TDIREIPIPEEY
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
GEE-------------------
P
-------------------------------------------
T
------------------------------------------------------------
E
--------------------------
E
------------
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
-----
T
P
V
F
L
G
S
A
L
K
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
IP
P
I
K
G
T
T
PEG
E
V
V
E
I
H
P---------
D
--------------------
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
-
P
Y
-
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
-
T
K
G
-----------------------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
-
I
T
-
G
-
D
T
L
V
G
E
D
---
A
---
P
R-
V
------
I
L
E
S
I
-
E
-
V
-
P
E
P
V
I
D
V
A
I
----
E
P
K
T
K
A
D
--
Q
E
---
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
---
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F-
K
-
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
-
I
------------------------------------------------------------------------------------------------------
T
K
P
V
D
V
E
G
K
F
I
R
QTGG
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
PRGS
G
F
E
F
V
N
AIVGGVIPKEY
I
P
A
V
Q
K
G
I
E
E
A
M
QSGPLIGFPVVD
I
K
V
T
L
Y
D
G
S
Y
H
EVDSS
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D-----------------------------------------------
P
---------------------------------------------------------
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
-
Q
I
L
G
M
E
P
R
G
--
N
A
Q
V
I
R
A
F
V
P
L
A
E
-
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
--
Y
Q
E
V
P
K
Q
------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
58.00
31%
10
- C1 -
-
2XEX
-
EFG_STAAU
B:
[5-681]
---------------
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
-
G
-----------
G
A
S
Q
M
D
W
M
E
Q
E
--------
S
A
A
T
T
A
A
W
E
-------
G
-----
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
-----------
F
-----------
E
Y
S
V
S
T
L
H
D
RLQANAAPI
Q
L
P
I
G
AEDEFEAII
D
L
V
E
M
K
C
F
K
--------------------------------
Y
TNDL-------------------------------------------------------------------
G
--------------------------------------------------------------
T
E
I
E
E
I
E
IPEDH
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
DEEI
S
------------------------------------------------------------
V
--------------------------
S
E
L
K
E
A
I
R
Q
A
T
T
N
V
------------
E
F
-----
Y
P
V
L
C
G
T
A
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
-
K
-
G
-
V
Q
L
M
L
D
A
V
I
D
Y
L
P
S
P
L
D
VK
P
I
I
G
H
R
ASNPE
E
E
V
I
A
K
A-------
D
--------------------
D
S
A
E
F
A
A
L
A
F
K
V
M
T
D
-
P
Y
-
V
G
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
-
T
K
G
-----------------------
K
R
E
R
V
G
R
L
L
Q
M
H
A
N
S
R
Q
E
I
D
T
V
Y
S
G
D
I
A
A
A
----
V
G
L
K
D
T
-
G
T
-
G
-
D
T
L
C
G
E
K
---
N
---
D
--
I
------
I
L
E
S
M
-
E
-
F
-
P
E
P
V
I
H
L
----
S
V
E
P
K
S
K
A
D
--
Q
D
---
K
M
T
Q
A
L
V
K
L
Q
E
E
D
P
T
F
H
A
H
T
--------
Q
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F-
N
-
V
E
C
N
V
G
A
P
M
V
S
Y
R
E
T
-
F
------------------------------------------------------------------------------------------------------
K
S
S
A
Q
V
Q
G
K
F
S
R
Q
SGG
R
G
Q
Y
G
D
V
H
I
E
F
T
P
N
E
TGA
G
F
E
F
E
N
AIVGGVVPREY
I
P
S
V
E
A
G
L
K
D
A
M
E
N
GVLAG
Y
P
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
DVDSS
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
CD-----------------------------------------------
P
---------------------------------------------------------
V
I
L
E
P
M
M
K
V
T
I
E
M
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
-
R
V
D
G
M
E
P
R
G
--
N
A
Q
V
V
N
A
Y
V
P
L
S
E
-
M
F
G
Y
A
T
S
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
--
Y
A
E
V
P
K
S
------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
57.62
31%
26
- C1 -
-
3J0E
-
EFG_ECOLI
H:
[4-692]
---------------
T
P
I
A
R
Y
R
N
I
G
I
S
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
F
Y
T
G
V
N
H
K
I
-
G
-------
E
VH
D
G
A
A
T
M
D
W
M
E
Q
E
Q
E
R
G
I
T
I
T
S
A
A
T
T
A
F
W
S
GMAKQYE
P
-----
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
V
M
V
Y
C
A
V
G
G
V
Q
P
Q
S
E
T
V
W
R
Q
A
N
K
Y
K
V
P
R
I
A
F
V
N
K
M
D
R
M
G
A
N
-----------
F
-----------
L
K
V
V
N
Q
I
K
------------------------
T
R
L
G
----
A
--------------------------------
N
-----------------------------------------------------------------------
P
VPLQLAIGAEEHFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMVELANEWHQNLIESAAE
A
-------------------------------------------
S
------------------------------------------------------------
E
ELMEKYLGGEELTEAEIKGALRQRVL
N
------------
N
------------
E
I
-----
I
L
V
T
C
G
S
A
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
K
-
G
-
V
Q
A
M
L
D
A
V
I
D
Y
L
P
S
P
V
D
---------------------------
V
PAINGILDDGKDTPAERHAS
D
D
E
P
F
S
A
L
A
F
K
I
A
T
D
-
P
F
-
V
G
N
L
T
F
F
R
V
Y
S
G
V
V
N
S
G
D
T
V
L
N
S
-
V
K
A
-----------------------
A
R
E
R
F
G
R
I
V
Q
M
H
A
N
K
R
E
E
I
K
E
V
R
A
G
D
I
A
A
A
----
I
G
L
K
D
V
-
T
T
-
G
-
D
T
L
C
D
P
D
---
A
---
P
--
I
------
I
L
E
R
M
-
E
-
F
-
P
E
P
V
I
S
I
A
V
E
----
P
K
T
K
A
D
--
Q
E
---
K
M
G
L
A
L
G
R
L
A
K
E
D
P
S
F
R
V
W
T
D
---
E
E
S
N
Q
T
I
I
A
G
M
G
E
L
H
L
D
I
I
V
D
R
M
K
R
E
F-
N
-
V
E
A
N
V
G
K
P
Q
V
A
Y
R
E
T-
I
------------------------------------------------------------------------------------------------------
R
QKVTDVEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAK-------------------------------------------
P
---------------------------------------------------------
V
L
L
E
P
I
M
K
V
E
V
E
T
P
E
E
N
T
G
D
V
I
G
D
L
S
R
R
R
G
-
M
L
K
G
Q
E
S
E
V
--
T
G
V
K
I
H
A
E
V
P
L
S
E
-
M
F
G
Y
A
T
Q
L
R
S
L
T
K
G
R
A
S
Y
T
M
E
F
L
K
--
Y
D
E
A
P
S
N
------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
55.55
25%
4
- C1 -
-
5MQF
-
U5S1_HUMAN
B:
[123-910]
--------------
M
D
N
S
E
L
I
R
N
V
T
L
C
G
H
L
H
H
G
K
T
C
F
V
D
C
L
I
E
Q
T
H
P
E
I
R
K
R
Y
-------
D
--
Q
D
L
C
Y
T
D
I
L
F
T
E
Q
E
R
G
V
G
I
K
S
T
P
V
T
V
V
L
P
-------
D
TKG
K
S
Y
L
F
N
I
M
D
T
P
G
H
V
N
F
S
D
E
V
T
A
G
L
R
I
S
D
G
V
V
L
F
I
D
A
A
E
G
V
M
L
N
T
E
R
L
I
K
H
A
V
Q
E
R
L
A
V
T
V
C
I
N
K
I
D
R
L
I
L
E
L
KLP
P
T
D
A
Y
Y
K
L
-----------
R
H
I
V
D
E
V
N
------------------------
G
L
I
S
----
M
--------------------------------
Y
-----------------------------------------------------------------------
S
--------------------------------------------------------------
T
-------------------------------------------
D
------------------------------------------------------------
E
---------------------------------------
N
------------
L
I
LSPLL
G
N
V
C
F
S
S
S
Q
Y
S
I
C
F
T
L
G
S
F
A
K
I
Y
A
D
T
FGDINY
Q
E
F
A
K
R
LWG
D
I
Y
F
N
PKT
R
K
F
T
KKAPTSSSQRSFVEFI
L
E
P
L
Y
K
I
L
A
Q
V
VGDVDTS
L
P
R
T
L
D
E
L
G
I
H
L
T
----------------------------------------------------------------
K
--------------------------------------------------------------------
E
E
L
K
LNI
R
P
L
L
R
L
V
C
---------------
K
--------------------------
K
F
-
F
-
G
E
F
T
G
F
V
D
M
C
V
Q
H
I
P
S
P
K
V
G
A
K
P
K
I
E
H
T
YTGGVDS
D
L
G
E
A
M
S
D
C
--
D
--------------------
P
D
G
P
L
M
C
H
T
T
K
M
Y
S
T
D
D
G
-
V
Q
F
H
A
F
G
R
V
L
S
G
T
I
H
A
G
Q
P
V
K
V
L
G
E
N
Y
TLEDEE
D
---------------
S
Q
I
C
T
V
G
R
L
W
I
S
V
A
R
Y
H
I
E
V
N
R
V
P
A
G
N
W
V
L
I
----
E
G
V
D
Q
P
I
V
K
-
T
-
A
T
I
T
E
P
R
---
G
NEE
A
--
Q
------
I
F
R
P
L
-
K
-
F
N
T
T
S
V
I
K
I
----
A
V
E
P
V
N
P
S
E
--
L
P
---
K
M
L
D
G
L
R
K
V
N
K
S
Y
P
S
L
T
T
K
V
E
----
E
S
G
E
H
V
I
L
G
T
G
E
L
Y
L
D
C
V
M
H
D
L
R
K
M
YS
E
-
I
D
I
K
V
A
D
P
V
V
T
F
C
E
T
-
V
------------------------------------------------------------------------------------------------------
V
ETSS
L
K
C
F
A
E
T
PNK
K
N
K
I
T
M
I
A
E
P
L
E
K
G
L
A
E
D
I
E
N
EVVQITWN
R
K
K
L
G
E
F
F
Q
T
K
YDWD
L
L
A
A
R
S
IWAFGPDATGP
N
I
L
V
D
D
T
L
P
S
E
V
D
K
A
L
L
G
S
V
K
D
S
I
V
Q
G
F
Q
W
G
T
R
E
GPLCDELIRN
V
K
F
K
I
L
D
A
V
V
A
QEPLHRGGGQI
I
P
T
A
R
R
V
V
Y
S
A
F
L
M
A
T
P
---------------------------------------------------------
R
L
M
E
P
Y
Y
F
V
E
V
Q
A
P
A
D
C
V
S
A
V
Y
T
V
L
A
R
R
R
G
-
H
V
T
Q
D
A
P
I
P
G
S
P
L
Y
T
I
K
A
F
I
P
A
I
D
-
S
F
G
F
E
T
D
L
R
T
H
T
Q
G
Q
A
F
S
L
S
V
F
H
H
--
W
Q
I
V
P
G
D
------------------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
55.17
20%
-5
- C1 -
-
5GMK
-
SN114_YEAST
C:
[128-943]
---------------
N
I
P
E
R
I
I
N
V
G
V
I
G
P
L
H
S
G
K
T
S
L
M
D
L
L
V
I
D
S
H
K
R
I
P
D
-
M
SKNVELG
W
--
K
P
L
R
Y
L
D
N
L
K
Q
E
I
D
R
G
L
S
I
K
L
N
G
S
T
L
L
C
T
DLESK--
S
-----
R
M
I
N
F
L
D
A
P
G
H
V
N
F
M
D
E
T
A
V
A
L
A
A
S
D
L
V
L
I
V
I
D
V
V
E
G
V
T
F
V
V
E
Q
L
I
K
Q
S
I
K
N
N
V
A
M
C
F
V
I
N
K
L
D
R
L
I
L
D
-----------
L
KLPPMDAYLKL
N
H
I
I
A
N
I
N
------------------------
S
F
T
K
----
G
--------------------------------
N
-----------------------------------------------------------------------
V
--------------------------------------------------------------
F
-------------------------------------------
S
----------------------------------------------------------------------------------------------------
P
------------
I
D
-----
N
N
I
I
F
A
S
T
K
L
G
F
T
F
T
I
K
----------------------------------------------------------------------------------
E
FVSYYYAHSIPSSKIDDFTTRLWGSVYYHKGNFRTKPFENVEKYPTFVEFILIPLYKIFSYALS
M
EKD-----------------------------------------------------------------
K
LKNL-------------------------
L
RSNFRVNLSQEALQYDPQPFLKHVLQ
L
I
F
R
-
Q
-
Q
T
G
L
V
D
A
I
T
R
C
Y
Q
-
P
F
E
LFDNKTAHLSIPGKS------------
T
--------------------
P
E
G
T
L
W
A
H
V
L
K
T
V
D
Y
--
G
-
G
A
E
W
S
L
V
R
I
Y
S
G
L
L
K
R
G
D
T
V
R
I
L
D
T
S
Q
------
S
ESREDDE--------
T
P
S
C
E
V
E
E
I
G
L
L
G
G
R
Y
V
Y
P
V
H
E
A
H
K
G
Q
I
V
L
I
----
K
G
I
S
S
A
-
Y
I
K
S
-
A
T
L
Y
S
V
K
---
S
---
K
--
E
DMKQLK
F
F
K
P
L
-
D
Y
I
-
T
E
A
V
F
----
K
I
V
L
Q
P
L
L
P
R
E
--
L
P
---
K
L
L
D
A
L
N
K
I
S
K
Y
Y
P
G
V
I
I
K
V
E
----
E
S
G
E
H
V
I
L
G
N
G
E
L
Y
M
D
C
L
L
Y
D
L
R
A
S
YA
K
-
I
E
I
K
I
S
D
P
L
T
V
F
S
E
SC
S
NSRLGEENLPGLSISVAAEPMDSKMIQDLSRNTLGKGQNCLDIDGIMDNPRKLSKILRTEYGWDSLASRNVWSFYNGNVLINDTLPDEISPELLSKYKEQII
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
FYWAVKEGPLAEEPIYGVQYKLLSISVPSDVNIDVMKSQIIPLMKKACYVGLLTAIP
I
L
L
E
P
I
Y
E
V
D
I
T
V
H
A
P
L
L
P
I
V
E
E
L
M
K
K
R
R
G
S
R
I
Y
K
T
I
K
V
A
G
T
P
L
L
E
V
R
G
Q
V
P
V
I
E
-
S
A
G
F
E
T
D
L
R
L
S
T
N
G
L
G
M
C
Q
L
Y
F
W
H
KI
W
R
K
V
P
G
D
------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
54.99
23%
1
- C1 -
-
3JB9
-
SN114_SCHPO
B:
[136-924]
---------------
T
G
T
D
D
V
R
S
F
I
V
A
G
H
L
H
H
G
K
S
A
L
L
D
L
L
V
Y
Y
T
H
P
D
T
K
P
-
P
K------
R
--
R
S
L
R
Y
T
D
T
H
Y
L
E
R
E
R
V
M
S
I
K
S
T
P
L
T
L
A
V
S
-------
D
MK
G
K
T
F
A
F
Q
C
I
D
T
P
G
H
V
D
F
V
D
E
V
A
A
P
M
A
I
S
D
G
V
V
L
V
V
D
V
I
E
G
V
M
I
N
T
T
R
I
I
K
H
A
I
L
H
D
M
P
I
V
L
V
L
N
K
V
D
R
L
I
L
E
LRLP
P
N
D
A
Y
H
K
L
-----------
R
H
V
I
D
E
V
N
------------------------
D
N
I
C
----
Q
--------------------------------
I
-----------------------------------------------------------------------
S
--------------------------------------------------------------
K
-------------------------------------------
D
------------------------------------------------------------
L
K
Y
R
V
----------------------
S
------------
P
------------
E
L
-----
G
N
V
C
F
A
S
C
D
L
G
Y
C
F
T
-
L
----------------------------------------------------------------------------------
S
----------------------------------------------------------------
S
F
A
K
L
Y
I
D
R
H
GGID
V
D
L
F
S
K
R
LWGD
I
Y
F
D
SKTRKFAKQSLDGSGVR
S
F
V
H
F
I
L
E
P
L
Y
K
L
H
T
L
T
I
S
DE
A
E
K
L
K
K
H
L
S
S
F
QIYLK
P
K
D
Y
L
LDP
K
P
L
L
Q
L
I
C
A
--------------------------
S
F
-
F
G
F
-
P
V
G
F
V
N
A
V
T
R
H
I
P
S
P
R
E
N
A
A
R
K
A
S
Q
S
YIGPINS
S
I
G
K
A
I
L
E
MSR
E
--------------------
E
S
A
P
L
V
M
H
V
T
K
L
Y
N
T
-
V
D
A
N
N
F
Y
A
F
A
R
V
Y
S
G
Q
V
K
K
G
Q
K
V
K
V
L
G
E
N
Y
SLEDEE
D
---------------
M
V
V
A
H
I
A
E
I
C
V
P
C
A
R
Y
R
L
H
V
D
G
A
V
A
G
M
L
V
L
L
----
G
G
V
D
N
S
-
I
S
-
K
T
A
T
I
V
S
D
N
LK
D
D
---
P
--
Y
------
I
F
R
P
I
A
H
-
M
-
S
E
S
V
F
K
V
----
A
V
E
P
H
N
P
S
E
--
L
P
---
K
L
L
D
G
L
R
K
T
N
K
S
Y
P
L
S
I
T
K
V
E
----
E
S
G
E
H
T
I
F
G
T
G
E
M
Y
M
D
C
L
L
Y
D
L
R
T
L
Y-
S
E
I
E
I
R
V
S
D
P
V
A
R
F
C
E
T
-
A
V
D
TSS
I
K
C
F
S
D
T
PNKK
N
R
I
T
M
V
V
E
P
L
E
K
G
I
S
N
D
I
E
N
GKVNINWP
Q
K
R
I
S
E
F
F
Q
K
NYDWD
L
L
A
S
R
S
IWAFGPDDRGT
N
I
L
R
D
D
T
L
S
T
D
V
D
K
N
V
L
N
S
V
K
E
Y
I
K
-
Q
G
F
Q
W
G
T
REGPLCD
E
T
I
R
N
V
N
F
R
L
M
D
V
V
L
A
P
E
QIYRGGGQI
I
P
T
A
R
R
V
C
Y
S
S
F
L
T
A
S
-----------------------------------------------------------------------------------------------------
P
---------------------------------------------------------
R
L
M
E
P
V
Y
M
V
E
V
H
A
P
A
D
S
L
P
I
I
Y
D
L
L
T
R
R
R
G
-
H
V
L
Q
D
I
P
R
P
G
S
P
L
Y
L
V
R
A
L
I
P
V
I
D
-
S
C
G
F
E
T
D
L
R
V
H
T
Q
G
Q
A
M
C
Q
M
V
F
D
H
--
W
Q
V
V
P
G
D
------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
53.81
25%
23
- C1 -
-
2DY1
1
?
A:
[6-652]
-----------------
G
A
M
I
R
T
V
A
L
V
G
H
A
G
S
G
K
T
T
L
T
E
A
L
L
Y
K
T
G
A
K
E
R
R
-
G
-------
R
VE
E
G
T
T
T
T
D
Y
T
P
E
A
K
L
H
R
T
T
V
R
T
G
V
A
P
L
L
F
R
-------
G
-----
H
R
V
F
L
L
D
A
P
G
Y
G
D
F
V
G
E
I
R
G
A
L
E
A
A
D
A
A
L
V
A
V
S
A
E
A
G
V
Q
V
G
T
E
R
A
W
T
V
A
E
R
L
G
L
P
R
M
V
V
V
T
K
L
D
K
G
G
D
------------
Y
-----------
Y
A
L
L
E
D
L
R
------------------------
S
T
L
G
----
P
--------------------------------
I
LPI
D
L
P
L
Y
E
GGKWVGLIDVFHG
K
A
Y
R
Y
E
NG
E
E
R
E
A
E
VPPEE
R
E
R
V
Q
R
F
R
Q
E
V
L
E
A
I
V
E
T
D
E
G
L
L
E
K
Y
L
E
G
E
E
--------------------------------------------------------------
V
-------------------------------------------
T
------------------------------------------------------------
G
--------------------------
E
A
L
E
K
A
F
H
E
A
V
R
R
G
------------
L
L
-----
Y
P
V
A
L
A
S
G
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
I
-
G
-
V
L
P
L
L
E
L
I
L
E
A
L
P
S
P
T
E
R--------------------------
F
--------------------
G
D
G
P
P
L
A
K
V
F
K
V
Q
V
D
-
P
F
-
M
G
Q
V
A
Y
L
R
L
Y
R
G
R
L
K
P
G
D
S
L
Q
S
E
-
A
-------------------------
G
Q
V
R
L
P
H
L
Y
V
P
M
G
K
D
L
L
E
V
E
E
A
E
A
G
F
V
L
G
V
----
P
K
A
E
G
L
-
H
R
-
G
-
M
V
L
W
Q
G
E
---
K
---
P
ES
E
------
E
V
P
F
A
-
R
-
L
-
P
D
P
N
V
P
V
----
A
L
H
P
K
G
R
T
D
--
E
A
---
R
L
G
E
A
L
R
K
L
L
E
E
D
P
S
L
K
L
E
R
Q
---
E
E
T
G
E
L
L
L
W
G
H
G
E
L
H
L
A
T
A
K
E
R
L
Q
D
Y
--
G
-
V
E
V
E
F
S
V
P
K
V
P
Y
R
E
T
-
I
------------------------------------------------------------------------------------------------------
K
K
V
A
E
G
Q
G
K
Y
K
K
Q
T
GG
H
G
Q
Y
G
D
V
W
L
R
L
E
P
A
S
E
Y
G
F
E
W
RITGGVIPSKY
Q
E
A
I
E
E
G
I
K
E
A
A
KKGVLAGFPVMG
F
K
A
I
VY
N
G
S
Y
H
EVDSS
D
L
A
F
Q
I
A
A
S
L
A
F
K
K
V
M
A
E
AH--------------------------------------------------
P
---------------------------------------------------------
V
L
L
E
P
I
Y
R
L
K
V
L
A
P
Q
E
R
V
G
D
V
L
S
D
L
Q
A
R
R
G
-
R
I
L
G
M
E
Q
E
G
--
A
L
S
V
V
H
A
E
V
P
L
A
E
-
V
L
E
Y
Y
K
A
L
P
G
L
T
G
G
A
G
A
Y
T
L
E
F
S
H
--
Y
A
E
V
P
P
H
------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
52.51
28%
22
- C1 -
-
3DEG
-
LEPA_ECOLI
C:
[2-541]
------------------
K
N
I
R
N
F
S
I
I
A
H
I
D
H
G
K
S
T
L
S
D
R
I
I
Q
I
C
G
G
L
S
D
R
-
E
----------
M
E
A
Q
V
L
D
S
M
D
L
E
R
E
R
G
I
T
I
K
A
Q
S
V
T
L
D
Y
K
ASDGE--
T
-----
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
V
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
L
E
V
V
P
V
L
N
K
I
D
L
P
A
A
D
-----------
P
-----------
E
R
V
A
E
E
I
E
------------------------
D
I
V
--------------------------------------------------------------------------------------------------------------
G
--------------------------------------------------------------
I
-------------------------------------------
D
------------------------------------------------------------------------------------------------------------------
A
-----
T
D
A
V
R
C
S
A
K
T
G
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
V
Q
D
V
L
E
R
L
V
R
D
I
P
P
P
E
G
---------------------------
D
--------------------
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
D
-
N
Y
-
L
G
V
V
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
K
V
M
S
-
T
G
-----------------------
Q
T
Y
N
A
D
R
L
G
I
F
T
P
-
K
Q
V
D
R
T
E
L
K
C
G
E
V
G
W
L
VCAI
K
D
I
H
G
A
-
P
V
-
G
-
D
T
L
T
L
A
R
---
N
---
P
AE
K
------
A
L
P
G
F
-
K
-----
K
V
K
P
Q
V
Y
A
-
G
L
F
P
V
S
S
D
D
--
Y
E
---
A
F
R
D
A
L
G
K
L
S
L
N
D
A
S
L
F
Y
E
P
E
SSS
A
L
G
F
G
F
R
C
G
F
L
G
L
L
H
M
E
I
I
Q
E
R
L
E
R
E
Y-
D
-
L
D
L
I
T
T
A
P
T
V
V
Y
E
V
--
E
T-----------------------------------------------------------------------------------------------------
T
SREVIYVDSPSKLPAVNNI------------------------------------------------------------------------------------------------------------------------------------------
Y
---------------------------------------------------------
E
L
R
E
P
I
A
E
C
H
M
L
L
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
-
V
Q
T
N
M
V
Y
H
G
--
N
Q
V
A
L
T
Y
E
I
P
M
A
E
V
V
L
D
F
F
D
R
L
K
S
T
S
R
G
Y
A
S
L
D
Y
N
F
K
R
--
F
Q
A
S
---
D
M
V
--
R
V
D
V
L
I
N
GERVDALALITHRDNS
Q
N
R
G
R
E
L
V
E
K
M
K
D
L
I
P
R
Q
Q
F
D
I
A
I
Q
A
A
I
G
-
T
H
I
I
A
R
S
T
------------------------------------------------------------------------------
138
HHSearch
52.44
20%
-7
- C1 -
-
5LJ3
-
SN114_YEAST
C:
[128-943]
---------------
N
I
P
E
R
I
I
N
V
G
V
I
G
P
L
H
S
G
K
T
S
L
M
D
L
L
V
I
D
S
H
K
R
I
P
D
-
M
SKNVELG
W
--
K
P
L
R
Y
L
D
N
L
K
Q
E
I
D
R
G
L
S
I
K
L
N
G
S
T
L
L
C
T
DLESK--
S
-----
R
M
I
N
F
L
D
A
P
G
H
V
N
F
M
D
E
T
A
V
A
L
A
A
S
D
L
V
L
I
V
I
D
V
V
E
G
V
T
F
V
V
E
Q
L
I
K
Q
S
I
K
N
N
V
A
M
C
F
V
I
N
K
L
D
R
L
I
L
D
-----------
L
KLPPMDAYLKL
N
H
I
I
A
N
I
N
------------------------
S
F
T
K
----
G
--------------------------------
N
-----------------------------------------------------------------------
V
--------------------------------------------------------------
F
-------------------------------------------
S
----------------------------------------------------------------------------------------------------
P
------------
I
D
-----
N
N
I
I
F
A
S
T
K
L
G
F
T
F
T
I
K
----------------------------------------------------------------------------------
E
FVSYYYAHSIPSSKIDDFTTRLWGSVYYHKGNFRTKPFENVEKYPTFVEFILIPLYKIFSYALS
M
EKD-----------------------------------------------------------------
K
LKNL-------------------------
L
RSNFRVNLSQEALQYDPQPFLKHVLQ
L
I
F
R
-
Q
-
Q
T
G
L
V
D
A
I
T
R
C
Y
Q
-
P
F
E
LFDNKTAHLSIPGKS------------
T
--------------------
P
E
G
T
L
W
A
H
V
L
K
T
V
D
Y
--
G
-
G
A
E
W
S
L
V
R
I
Y
S
G
L
L
K
R
G
D
T
V
R
I
L
D
T
S
Q
------
S
ESRQKRQLHDIEDDE
T
P
S
C
E
V
E
E
I
G
L
L
G
G
R
Y
V
Y
P
V
H
E
A
H
K
G
Q
I
V
L
I
----
K
G
I
S
S
A
-
Y
I
K
S
-
A
T
L
Y
S
V
K
---
S
---
K
--
E
DMKQLK
F
F
K
P
L
-
D
Y
I
-
T
E
A
V
F
----
K
I
V
L
Q
P
L
L
P
R
E
--
L
P
---
K
L
L
D
A
L
N
K
I
S
K
Y
Y
P
G
V
I
I
K
V
E
----
E
S
G
E
H
V
I
L
G
N
G
E
L
Y
M
D
C
L
L
Y
D
L
R
A
S
YA
K
-
I
E
I
K
I
S
D
P
L
T
V
F
S
E
SC
S
NESFASIPVSNISVAAEPMDSKMIQDLSRPRKLSKILRTEYGWDSLASRNVWSFYNLINDTLPDEISPELLSKYKEQII-----------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
FYWAVKEGPLAEEPIYGVQYKLLSISVPSDVNIDVMKSQIIPLMKKACYVGLLTAIP
I
L
L
E
P
I
Y
E
V
D
I
T
V
H
A
P
L
L
P
I
V
E
E
L
M
K
K
R
R
G
S
R
I
Y
K
T
I
K
V
A
G
T
P
L
L
E
V
R
G
Q
V
P
V
I
E
-
S
A
G
F
E
T
D
L
R
L
S
T
N
G
L
G
M
C
Q
L
Y
F
W
H
KI
W
R
K
V
P
G
D
------------------------------------------------------------------------------------------------------------------------------------------------
149
HHSearch
51.97
33%
-23
* C1 *
-
5VH6
-
EFG_BACSU
A:
[7-403]
--------------
E
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
F
Y
T
G
R
I
---------------------------------
I
T
S
A
A
T
T
A
Q
W
K
-------
G
-----
Y
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
A
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
I
G
A
D
-----------
F
-----------
L
Y
S
V
G
T
L
R
------------------------
D
R
L
Q
----
A
--------------------------------
N
-----------------------------------------------------------------------
A
H-------------------------------------------------------------
A
IQLPIGAEDNFEGI-----------------------------
I
DLVEN
V
A
Y
F
Y
EDDLGTRSDAKEIPEEY
K
E
Q
A
E
E
L
R
N
S
L
I
E
A
V
C
E
L
D
E
E
L
M
D
K
Y
L
E
G
E
E
I
T
I
--------------------------
D
E
L
K
A
--------
G
I
R
K
G
T
L
N
V----
E
F
-----
Y
P
V
L
V
G
S
A
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
-
K
-
G
-
V
Q
L
V
L
D
A
V
L
D
Y
L
P
A
P
T
D
VAA
I
K
G
T
R
P
DTN
E
E
I
E
R
H
S--------
S
--------------------
D
E
E
P
F
S
A
L
A
F
K
V
M
T
D
-
P
Y
-
V
G
K
L
T
F
F
R
V
Y
S
G
T
L
D
S
G
S
Y
V
K
N
S
-
T
K
G
-----------------------
K
R
E
R
V
G
R
I
L
Q
M
H
A
N
S
R
E
E
I
S
T
V
Y
A
G
D
I
A
A
A
----
V
G
L
K
D
T
-
T
T
-
G
-
D
T
L
C
D
E
K
---
D
---
L
--
V
------
I
L
E
S
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------