@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U2U9: (2017-12-23 )
MIFSERMGEMTRLRAADIAAGYENKKIIENMSVTIPEGKITSLIGPNGSGKSTLLKSFTRILPVKSGKIIVNNSDISTYSSKELAKKIALLAQTSEHPTGMTVEEVVSYGRYPYQKLFSGMDTQDHEAIEWALDATGLAGFRMRDIATLSGGQTQRVWIAMALAQETDILILDEPTTFLDPAHQLEILQLLTEINQMKQTTILMSIHDINHASRFSDYLLAMKNGKLITEGTPEEVITKECMKKIFEIDATIVTLPRTNKPVFLTYDLLPKEQEDQL
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80.---.-------------..---.-...90...-.....-100...-----....110---........-.120...-....130---.......140......----.150.......160...------....170.......180.......190.......200.......210.......220.......230.....-------.-.240.......250.......260.......270.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
F
S
E
R
M
G
E
M
T
R
L
R
A
A
D
IAAGYENK
K
I
IEN
M
S
V
TIPEG
K
I
T
S
L
IGPNGS
G
K
S
T
L
L
K
S
F
T
R
I
L
PVKS
G
K
I
I
V
NNSDISTY
S
S
K
---
E
-------------
L
A
---
K
-
K
I
A
L
L
AQT-SEHPT-GM
T
V
E
E
-----
V
V
S
YG-----R
Y
P
Y
Q
K
L
F-SGMDTQ
D
-
H
E
A
I
E
W
A
---LDATGLA
G
F
R
M
R
D
I
A
T----LSGGQ
T
Q
R
V
W
I
A
M
ALAQ------ET
D
I
L
I
LDEPTTFLD
P
A
H
Q
L
E
I
L
Q
L
L
T
E
I
N
Q
M
K
Q
T
T
I
L
M
S
I
HDIN
H
A
S
R
F
S
D
Y
L
L
A
MKN
G
K
L
ITEGT
P
E
E
V
I
-------
T
-
K
E
C
M
K
K
I
F
EID
A
T
I
V
TLPRTNK
P
V
F
L
T
Y
DLLPKEQEDQL
1
PsiBlast_PDB
80.55
32%
-65
- C1 -
-
4G1U
-
HMUV_YERPE
C:
[12-260]
------------
L
E
A
S
H
L
H
Y
H
V
Q
Q
Q
A
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
H
L
L
G
Q
N
L
N
S
W
Q
P
K
---
A
-------------
L
A
---
R
-
T
R
A
V
M
R
Q
Y
-
S
E
L
A
F
-
P
F
S
V
S
E
-----
V
I
Q
M
G
-----
R
A
P
Y
G
-------
G
S
Q
D
-
R
Q
A
L
Q
Q
V
---
M
A
Q
T
D
C
L
A
L
A
Q
R
D
Y
R
V
----
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
WQPQP
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
-------
N
-
A
E
T
L
T
Q
W
Y
Q
A
D
L
G
V
S
R
H
P
E
S
A
L
P
----------------
28
PsiBlast_CBE
77.42
31%
-119
- C1 -
-
3TUI
1
METN_ECOLI
D:
[37-253]
--------------------
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
---
E
-------------
L
T
---
K
-
A
R
R
Q
I
G
M
I
-
F
Q
H
F
N
-
L
L
S
S
R
T
-----
V
F
G
N
V
-----
A
L
P
L
E
L
D
N
-
T
P
K
D
E
V
K
-
R
R
V
T
E
L
----
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-------
S
----------------------------------------
12
PsiBlast_PDB
75.36
31%
-122
- C1 -
-
3TUI
1
METN_ECOLI
C:
[37-253]
--------------------
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
---
E
-------------
L
T
---
K
-
A
R
R
Q
I
G
M
I
-
F
Q
H
F
N
-
L
L
S
S
R
T
-----
V
F
G
N
V
-----
A
L
P
L
E
L
D
N
-
T
P
K
D
E
V
K
-
R
R
V
T
E
L
----
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-------
S
----------------------------------------
27
PsiBlast_CBE
73.95
31%
-117
- C1 -
-
3TUI
1
METN_ECOLI
G:
[37-253]
--------------------
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
---
E
-------------
L
T
---
K
-
A
R
R
Q
I
G
M
I
-
F
Q
H
F
N
-
L
L
S
S
R
T
-----
V
F
G
N
V
-----
A
L
P
L
E
L
D
N
-
T
P
K
D
E
V
K
-
R
R
V
T
E
L
----
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-------
S
----------------------------------------
13
PsiBlast_PDB
73.72
31%
-125
- C1 -
-
3TUZ
1
METN_ECOLI
C:
[37-253]
--------------------
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
---
E
-------------
L
T
---
K
-
A
R
R
Q
I
G
M
I
-
F
Q
H
F
N
-
L
L
S
S
R
T
-----
V
F
G
N
V
-----
A
L
P
L
E
L
D
N
-
T
P
K
D
E
V
K
-
R
R
V
T
E
L
----
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-------
S
----------------------------------------
25
PsiBlast_CBE
73.55
31%
-120
- C1 -
-
3TUZ
1
METN_ECOLI
D:
[37-253]
--------------------
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
---
E
-------------
L
T
---
K
-
A
R
R
Q
I
G
M
I
-
F
Q
H
F
N
-
L
L
S
S
R
T
-----
V
F
G
N
V
-----
A
L
P
L
E
L
D
N
-
T
P
K
D
E
V
K
-
R
R
V
T
E
L
----
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-------
S
----------------------------------------
11
PsiBlast_PDB
73.49
31%
-126
- C1 -
-
3DHW
-
METN_ECOLI
C:
[14-230]
--------------------
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
---
E
-------------
L
T
---
K
-
A
R
R
Q
I
G
M
I
-
F
Q
H
F
N
-
L
L
S
S
R
T
-----
V
F
G
N
V
-----
A
L
P
L
E
L
D
N
-
T
P
K
D
E
V
K
-
R
R
V
T
E
L
----
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-------
S
----------------------------------------
23
PsiBlast_CBE
73.48
31%
-126
- C1 -
-
3TUZ
1
METN_ECOLI
H:
[37-253]
--------------------
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
---
E
-------------
L
T
---
K
-
A
R
R
Q
I
G
M
I
-
F
Q
H
F
N
-
L
L
S
S
R
T
-----
V
F
G
N
V
-----
A
L
P
L
E
L
D
N
-
T
P
K
D
E
V
K
-
R
R
V
T
E
L
----
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-------
S
----------------------------------------
24
PsiBlast_CBE
72.00
31%
-120
- C1 -
-
3TUZ
1
METN_ECOLI
G:
[37-253]
--------------------
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
---
E
-------------
L
T
---
K
-
A
R
R
Q
I
G
M
I
-
F
Q
H
F
N
-
L
L
S
S
R
T
-----
V
F
G
N
V
-----
A
L
P
L
E
L
D
N
-
T
P
K
D
E
V
K
-
R
R
V
T
E
L
----
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-------
S
----------------------------------------
14
PsiBlast_PDB
70.77
31%
-125
- C1 -
-
3TUJ
-
METN_ECOLI
C:
[14-230]
--------------------
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
---
E
-------------
L
T
---
K
-
A
R
R
Q
I
G
M
I
-
F
Q
H
F
N
-
L
L
S
S
R
T
-----
V
F
G
N
V
-----
A
L
P
L
E
L
D
N
-
T
P
K
D
E
V
K
-
R
R
V
T
E
L
----
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-------
S
----------------------------------------
26
PsiBlast_CBE
70.48
31%
-125
- C1 -
-
3TUI
1
METN_ECOLI
H:
[37-253]
--------------------
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
---
E
-------------
L
T
---
K
-
A
R
R
Q
I
G
M
I
-
F
Q
H
F
N
-
L
L
S
S
R
T
-----
V
F
G
N
V
-----
A
L
P
L
E
L
D
N
-
T
P
K
D
E
V
K
-
R
R
V
T
E
L
----
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-------
S
----------------------------------------
53
HHSearch
67.19
26%
-118
* C1 *
-
4YER
2
?
A:
[3-254]
---------
E
D
I
I
V
V
E
N
L
V
K
K
F
G
D
F
E
A
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
W
V
A
G
H
D
V
L
K
-
E
P
R
---
E
-------------
V
R
---
R
-
K
I
G
I
V
F
Q
D
-
Q
S
L
D
R
-
E
L
T
A
Y
E
-----
N
M
Y
I
H
-----
G
K
I
Y
G
Y
---
G
--
G
E
K
L
-
K
K
R
I
L
E
L
---
L
E
F
V
E
L
L
E
F
K
D
K
P
V
K
T
----
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
------
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
Y
I
S
K
M
K
K
E
H
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
A
L
G
T
P
T
E
L
K
-------
R
----------------------------------------
54
HHSearch
66.32
22%
-126
- C1 -
-
3RLF
2
MALK_ECOLI
A:
[2-223]
----------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
-----
P
-------------
A
E
---
R
-
G
V
G
M
V
F
Q
S
-
Y
A
L
Y
P
-
H
L
S
V
A
E
-----
N
M
S
F
G
-----
L
K
L
A
G
A
-----
K
K
E
V
I
-
N
Q
R
V
N
Q
V
---
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
----
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
-------
H
----------------------------------------
43
PsiBlast_CBE
64.97
31%
-36
- C1 -
-
1B0U
1
HISP_SALTY
A:
[5-241]
----------
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
K
---
D
GQLKVAD
K
N
Q
L
R
L
L
R
---
T
-
R
L
T
M
V
F
Q
H
-
F
N
L
W
S
-
H
M
T
V
L
E
-----
N
V
M
E
A
-------
P
I
Q
V
L
---
G
L
S
K
---
H
D
A
R
E
R
A
---
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
K
YPVH
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
------
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
T
M
V
V
V
T
-
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
------------------------------------------------
20
PsiBlast_PDB
64.93
29%
-20
- C1 -
-
2OLK
1
?
A:
[38-263]
-------------------------
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
-------------
V
R
---
E
-
E
V
G
M
V
F
Q
R
-
F
N
L
F
P
-
H
M
T
V
L
N
-----
N
I
T
L
A
PMKVR
K
W
P
R
E
K
--------
A
E
-
A
K
A
M
E
L
----
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
-
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
DRPQH
E
R
T
-
K
A
F
L
S
K
V
F
-------------------------------
29
PsiBlast_CBE
64.83
31%
-62
- C1 -
-
4HLU
1
ECFA1_THEMA
C:
[11-230]
-----------
R
I
E
L
N
S
V
S
F
R
Y
N
G
D
Y
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
-
A
G
E
I
F
L
D
G
S
P
A
D
P
F
L
-------------------
L
R
---
K
-
N
V
G
Y
V
F
Q
N
P
S
S
Q
I
I
-
G
A
T
V
E
E
-----
D
V
A
F
S
-----
L
E
-----
I
-
M
G
L
D
E
S
E
M
R
K
R
I
K
K
V
---
L
E
L
V
G
L
S
G
L
A
A
A
D
P
L
N
----
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
------
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
K
N
E
G
K
G
I
I
L
V
T
-
H
E
L
E
Y
L
D
D
M
-
D
F
I
L
H
I
S
N
G
T
I
D
F
C
G
S
W
E
E
F
V
-------
E
-
R
E
-------------------------------------
2
PsiBlast_PDB
64.60
33%
-24
- C1 -
-
3GFO
-
ECFA3_CLOP1
A:
[24-241]
---------------------------
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
D
-
Y
S
R
K
G
I
M
K
-------------
L
R
---
E
-
S
I
G
I
V
F
Q
D
-
P
D
N
Q
L
F
S
A
S
V
Y
Q
-----
D
V
S
F
G
A
V
N
M
-
K
L
P
E
D
E
I
----------
R
K
R
V
D
N
A
---
L
K
R
T
G
I
E
H
L
K
D
K
P
T
H
C
----
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
------
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
-------
A
E
K
E
V
I
R
K
V
--------------------------------
19
PsiBlast_PDB
62.92
29%
-28
- C1 -
-
2OLJ
3
?
A:
[38-263]
-------------------------
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
-
K
-------------
V
R
---
E
-
E
V
G
M
V
F
Q
R
-
F
N
L
F
P
-
H
M
T
V
L
N
-----
N
I
T
L
A
PMKVR
K
W
P
R
E
K
--------
A
E
-
A
K
A
M
E
L
----
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
-
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
RPQH
E
R
T
-
K
A
F
L
S
K
V
F
-------------------------------
55
HHSearch
62.68
22%
-122
- C1 -
-
2AWN
1
MALK_ECOLI
B:
[2-223]
----------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
-----
P
-------------
A
E
---
R
-
G
V
G
M
V
F
Q
S
-
Y
A
L
Y
P
-
H
L
S
V
A
E
-----
N
M
S
F
G
-----
L
K
L
A
G
A
-----
K
K
E
V
I
-
N
Q
R
V
N
Q
V
---
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
----
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
-------
H
----------------------------------------
36
PsiBlast_CBE
61.18
31%
-26
- C1 -
-
1G6H
1
LIVG_METJA
A:
[5-241]
---------
M
E
I
L
R
T
E
N
I
V
K
Y
F
G
E
F
K
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
K
D
I
T
N
K
E
P
A
---
E
-------------
L
Y
---
H
Y
G
I
V
R
T
F
Q
T
-
P
Q
P
L
K
-
E
M
T
V
L
E
N
L
L
I
G
E
I
C
P
G
-----
E
S
P
L
N
S
L
F
Y
K
K
W
I
P
K
E
-
E
E
M
V
E
K
A
F
K
I
L
E
F
L
K
L
S
H
L
Y
D
R
K
A
G
E
----
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
------
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
-
K
A
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
------------------------------------------------
34
PsiBlast_CBE
58.68
31%
-26
- C1 -
-
1G9X
1
LIVG_METJA
B:
[5-241]
---------
M
E
I
L
R
T
E
N
I
V
K
Y
F
G
E
F
K
A
L
D
G
V
S
I
S
V
C
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
K
D
I
T
N
K
E
P
A
---
E
-------------
L
Y
---
H
Y
G
I
V
R
T
F
Q
T
-
P
Q
P
L
K
-
E
M
T
V
L
E
NLLIG
E
I
N
P
G
-----
E
S
P
L
N
S
L
F
Y
K
K
W
I
P
K
E
-
E
E
M
V
E
K
A
FKI
L
E
F
L
K
L
S
H
L
Y
D
R
K
A
G
E
----
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
------
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
-
K
A
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
------------------------------------------------
33
PsiBlast_CBE
58.03
31%
-20
- C1 -
-
1G9X
1
LIVG_METJA
C:
[5-241]
---------
M
E
I
L
R
T
E
N
I
V
K
Y
F
G
E
F
K
A
L
D
G
V
S
I
S
V
C
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
K
D
I
T
N
K
E
P
A
---
E
-------------
L
Y
---
H
Y
G
I
V
R
T
F
Q
T
-
P
Q
P
L
K
-
E
M
T
V
L
E
NLLIG
E
I
N
P
G
-----
E
S
P
L
N
S
L
F
Y
K
K
W
I
P
K
E
-
E
E
M
V
E
K
A
FKI
L
E
F
L
K
L
S
H
L
Y
D
R
K
A
G
E
----
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
------
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
-
K
A
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
------------------------------------------------
22
PsiBlast_CBE
55.75
31%
-8
- C1 -
-
5X40
2
CBIO_RHOCB
B:
[31-244]
-------------------------
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
V
L
L
G
G
T
-
A
T
G
H
S
R
K
---
D
-------------
L
T
GWR
R
-
R
V
G
L
V
L
Q
D
-
A
D
D
Q
L
F
A
T
T
V
F
E
-----
D
V
S
F
G
-------
P
L
N
L
G
L
-
S
--
E
A
E
A
-
R
A
R
V
E
E
A
---
L
A
A
L
S
I
S
D
L
R
D
R
P
T
H
M
----
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
------
R
P
E
V
L
L
L
D
Q
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
L
L
R
G
L
-
R
A
A
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
R
T
G
R
V
L
A
E
G
A
A
E
A
V
L
-------
S
-
D
R
A
------------------------------------
10
PsiBlast_PDB
53.14
31%
-12
- C1 -
-
5X40
2
CBIO_RHOCB
A:
[31-244]
-------------------------
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
V
L
L
G
G
T
-
A
T
G
H
S
R
K
---
D
-------------
L
T
G
W
R
R
-
R
V
G
L
V
L
Q
D
-
A
D
D
Q
L
F
A
T
T
V
F
E
-----
D
V
S
F
G
-------
P
L
N
L
G
L
-
S
--
E
A
E
A
-
R
A
R
V
E
E
A
---
L
A
A
L
S
I
S
D
L
R
D
R
P
T
H
M
----
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
------
R
P
E
V
L
L
L
D
Q
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
L
L
R
G
L
-
R
A
A
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
R
T
G
R
V
L
A
E
G
A
A
E
A
V
L
-------
S
-
D
R
A
------------------------------------