@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XWP1: (2017-12-31 )
MPKNKNETLCVEDLRHAEYYEMQNTFDDLYAKSKNGDIFTHLMDIILSRENILLAYRNIKANAGSKTAGTDGTIIKDIGKLPAETVVKKVRYIVAGSPHGYRPKPVRRKEIPKPNGKTRPLGIPCMWDRLIQQCIKQVLEPICEAKFSENSYGFRPNRSVENAIKATYNRLQISQLHYVIEFDIKGFFDNVNHSKLIKQIWAMGIRDKHLIFILKRILKAPIKMTNGTITYPEKGTPQGGIISPLLANIVLNELDHWVESQWQENPVTKNYVVHINKSGSPCKSNAYKEMKKTKLKEMYMVRYADDFRVFCRYKESAEKAKIAITQWIEQRLKLEVSQEKTRIVNVRKRYSDFLGFKIKMIPRRKKLVVKSHISDKQFKNQKDKLVSQAKKIASPSKGKTELEETRLYNSMVLGMQNYYQIATNVNLDCMKLNRAVMAIFTNRLGTNKRGRLRKTGRQLTTKEATRYGKSKMLRYVAGEGEPIFPVGYIQHRKPMAKVYLANCYTLEGRKFIHTNLSVDKLLMYQLMKLSLENRTIEYADNRISLFSAQHGKCAITLEEFQQANEIHCHHIVPTGAGGNDDYKNLILVKEAVHRLIHAKTEETIQKYIALLKLNKVQLIRLNKYRVLAGNQELNLI
Atome Classification :
(20 SA)
-------------.........10........20........30.......--.40........50........60........70.---.......80........90........100.......110..-..-.-.--.120.......--130.......140.......150.......160......-.170.......180.......190.------------------------......200...---.....210.......220.......230.------.--.....240........250....--------..---------.260.......270----...-----------......280.......290.......300.......310---------..-.......320......-.330.......340.....----..350.......360....-------....370---------------.......380........390..--.------------....-----400....-...410.......420.......430.......440....-...450.......460....-..----.470.......480.......----------490-.......500.......510.......520.......530.......540.---......-550.......560.......570.....----..580.-......590......--------------------.600.......610....-...620.......630....----------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------MPKNKNET
L
C
V
E
D
L
R
H
A
E
Y
Y
E
M
Q
N
T
F
D
D
L
YAKSKNG
D
I
--
F
T
H
L
M
D
I
I
LSRE
N
I
L
L
A
Y
R
N
IKANAGSKTAGTD
G
---
T
I
I
K
D
I
GKL
P
A
E
T
V
V
K
K
V
R
Y
I
V
AGSPHGYRPKPVRRKEIPKP-NG-K-T--RPLGI
P
C
M
W
D
R
--
L
I
Q
Q
C
I
K
Q
V
L
E
P
I
C
EAKFSENSYGFRPNR
S
V
E
N
A
I
K
A
T
Y
-
N
R
L
Q
I
S
Q
L
H
Y
V
I
E
F
DI
K
G
FFDNV
N
H
------------------------
S
K
L
I
K
Q
I
W
-
A
MG---IRD
K
H
L
I
F
I
L
K
R
I
L
KAPIKMTN
G
T
I
TYPE------K--GTPQGG
I
-
I
S
P
L
L
A
N
I
V
L
N
E
L
D
H
--------
W
V
---------
E
S
Q
WQENPVTK
N
------
Y
V
V
-----------
H
INKSGSPCK
S
N
A
Y
K
E
M
K
K
T
K
L
K
E
M
Y
M
V
R
YADD
F
R
V
F
-----------
C
R
-YKESA
E
K
A
K
I
A
I
T
Q
W
I
-
E
Q
R
L
K
L
EVSQE
K
T
R
I
V
N
V
R
----
K
R
Y
S
D
FL
G
F
K
I
K
M-IPRRK-------K
L
V
V
K
SH---------------IS
D
K
Q
F
K
N
-
Q
K
D
K
L
V
S
Q
A
K
K
IAS--P------------SKGK-----
T
E
L
E
E
T
R
-
L
Y
N
S
M
V
L
G
M
Q
N
Y
Y
Q
I
ATNV
N
L
D
C
M
K
L
N
R
A
V
M
A
I
F
T
N
RLGT-NKR
G
R
L
R
K
TGRQ
L
T
T
K
E
A
T
R-Y
G
----
K
S
K
M
L
R
Y
VAGEG
E
P
I
F
P
V
G
Y
I
----------
Q
HR-KPM
A
K
V
Y
L
A
N
C
Y
T
LEG
R
K
F
I
HTNL
S
V
D
K
L
L
M
Y
Q
L
M
K
L
SLEN
R
T
I
E
YAD
N
R
I
---
S
L
F
SAQ-HG
K
C
A
I
T
L
E
E
F
Q
Q
ANE
I
H
C
H
H
I
V
PTGAG----GND
D
Y
K
-
N
L
I
L
V
K
E
A
V
H
R
L
I
HA--------------------
K
T
E
E
T
I
Q
K
Y
I
A
L
L
KLN
K
V
-
Q
L
I
R
LN
K
Y
R
V
LAGNQELNLI----------------------
43
Fugue
79.83
37%
-114
- C3 -
-
5HHJ
4
?
A:
[12-305]
------------------------------------------------
R
M
D
--
T
S
S
L
M
E
Q
I
L
S
N
D
N
L
N
R
A
Y
L
Q
V
V
R
N
K
G
A
E
--
G
V
D
G
---
M
K
Y
T
E
L
K
E
Y
L
A
K
N
G
E
I
I
K
E
Q
L
R
---
I
R
K
Y
K
P
Q
P
V
R
R
V
E
I
P
K
P
-
D
G
-
G
-
V
--
R
N
L
G
V
P
T
V
T
D
R
--
F
I
Q
Q
A
I
A
Q
V
L
T
P
I
Y
E
E
Q
F
H
D
H
S
Y
G
F
R
P
N
R
C
A
Q
Q
A
I
L
T
A
L
-
D
M
M
N
-
D
G
N
D
W
I
V
D
I
D
L
E
K
F
F
D
T
V
N
H
------------------------
D
K
L
M
T
I
I
G
-
R
-
T
---
I
K
D
G
D
V
I
S
I
V
R
K
Y
L
V
S
G
I
-
M
I
D
D
E
Y
E
D
S
I
------
V
--
G
T
P
Q
G
G
N
-
L
S
P
L
L
A
N
I
M
L
N
E
L
D
K
--------
E
M
---------
E
K
----------------------------------------------------
R
G
L
N
F
V
R
Y
A
D
D
C
I
I
M
-----------
V
G
-
S
E
M
S
A
N
R
V
M
R
N
I
S
R
F
I
-
E
E
K
L
G
L
K
V
N
M
T
K
S
K
V
D
R
P
R
----
G
I
--
K
Y
L
G
F
G
F
Y
Y
-
D
T
S
A
Q
-------
Q
F
K
A
K
P
H
---------------
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
77.35
37%
-122
- C3 -
-
5HHJ
4
?
A:
[15-294]
-----------------------------------------------------
T
S
S
L
M
E
Q
I
L
S
N
D
N
L
N
R
A
Y
L
Q
V
V
R
--
N
K
G
A
E
G
V
D
G
---
M
K
Y
T
E
L
K
E
Y
L
A
K
-
N
G
E
I
I
K
E
Q
L
R
I
--
R
K
Y
K
P
Q
P
V
R
R
V
E
I
P
K
P
-
D
G
-
G
-
V
--
R
N
L
G
V
P
T
V
T
D
R
--
F
I
Q
Q
A
I
A
Q
V
L
T
P
I
Y
E
E
Q
F
H
D
H
S
Y
G
F
R
P
N
R
C
A
Q
Q
A
I
L
T
A
L
-
D
M
M
N
D
-
G
N
D
W
I
V
D
I
D
L
E
K
F
F
D
T
V
N
H
------------------------
D
K
L
M
T
I
I
G
-
R
T
I
---
K
D
G
D
-
V
I
S
I
V
R
K
Y
L
V
S
G
I
M
I
D
D
-
E
Y
E
D
S
I
------
V
--
G
T
P
Q
G
G
N
-
L
S
P
L
L
A
N
I
M
L
N
E
L
D
K
--------
E
M
---------
E
K
----------------------------------------------------
R
G
L
N
F
V
R
Y
A
D
D
C
I
I
M
-----------
V
G
-
S
E
M
S
A
N
R
V
M
R
N
I
S
R
F
I
-
E
E
K
L
G
L
K
V
N
M
T
K
S
K
V
D
R
------
P
R
G
I
K
Y
L
G
F
G
F
Y
Y
-
D
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
75.26
37%
-97
- C3 -
-
5HHL
-
?
A:
[3-282]
-----------------------------------------------------
T
S
N
L
M
E
Q
I
L
S
S
D
N
L
N
R
A
Y
L
Q
V
V
R
--
N
K
G
A
E
G
V
D
G
---
M
K
Y
T
E
L
K
E
H
L
A
K
-
N
G
E
T
I
K
G
Q
L
R
T
--
R
K
Y
K
P
Q
P
A
R
R
V
E
I
P
K
P
-
D
G
-
G
-
V
--
R
N
L
G
V
P
T
V
T
D
R
--
F
I
Q
Q
A
I
A
Q
V
L
T
P
I
Y
E
E
Q
F
H
D
H
S
Y
G
F
R
P
N
R
C
A
Q
Q
A
I
L
T
A
L
-
N
I
M
N
D
-
G
N
D
W
I
V
D
I
D
L
E
K
F
F
D
T
V
N
H
------------------------
D
K
L
M
T
L
I
G
-
R
T
I
---
K
D
G
D
-
V
I
S
I
V
R
K
Y
L
V
S
G
I
M
I
D
D
-
E
Y
E
D
S
I
------
V
--
G
T
P
Q
G
G
N
-
L
S
P
L
L
A
N
I
M
L
N
E
L
D
K
--------
E
M
---------
E
K
----------------------------------------------------
R
G
L
N
F
V
R
Y
A
D
D
C
I
I
M
-----------
V
G
-
S
E
M
S
A
N
R
V
M
R
N
I
S
R
F
I
E
E
-
K
L
G
L
K
V
N
M
T
K
S
K
V
D
R
------
P
S
G
L
K
Y
L
G
F
G
F
Y
F
-
D
P
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.13
35%
5
- C3 -
-
5HHL
-
?
A:
[4-291]
------------------------------------------------------
S
N
L
M
E
Q
I
L
S
S
D
N
L
N
R
A
Y
L
Q
V
V
R
N
K
G
A
E
--
G
V
D
G
MKY
T
E
L
K
E
H
L
A
K
N
G
E
T
I
K
G
Q
L
R
------
T
R
K
Y
K
P
Q
P
A
R
R
V
E
I
P
K
P
-
D
G
-
G
-
V
--
R
N
L
G
V
P
T
V
T
D
R
--
F
I
Q
Q
A
I
A
Q
V
L
T
P
I
Y
E
E
Q
F
H
D
H
S
Y
G
F
R
P
N
R
C
A
Q
Q
A
I
L
T
A
L
-
N
I
M
N
D
G
N
-
D
W
I
V
D
I
D
L
E
K
F
F
D
T
V
N
H
------------------------
D
K
L
M
T
L
I
--
G
R
T
---
I
K
D
G
D
V
I
S
I
V
R
K
Y
L
V
S
G
I
-
M
I
D
D
E
Y
E
D
S
I
------
V
--
G
T
P
Q
G
G
N
-
L
S
P
L
L
A
N
I
M
L
N
E
L
D
------------------------------------------------------------------
K
E
M
E
K
R
G
L
N
---
F
V
R
Y
A
D
D
C
I
I
M
-----------
V
G
-
S
E
M
S
A
N
R
V
M
R
N
I
S
R
F
I
-
E
E
K
L
G
L
K
V
N
M
T
K
S
K
V
--
D
R
----
P
S
G
L
K
Y
L
G
F
G
F
Y
F
-
D
P
R
A
H
-------
Q
F
K
A
K
P
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_CBE
69.05
36%
-3
- C3 -
-
5HHJ
1
?
B:
[16-287]
------------------------------------------------------
S
S
L
M
E
Q
I
L
S
N
D
N
L
N
R
A
Y
L
Q
V
V
R
N
K
G
A
E
--
G
V
D
G
MKY
T
E
L
K
E
Y
L
A
K
N
G
E
I
I
K
E
Q
L
R
I
------
R
K
Y
K
P
Q
P
V
R
R
V
E
I
P
K
P
-
D
G
-
G
-
V
--
R
N
L
G
V
P
T
V
T
D
R
--
F
I
Q
Q
A
I
A
Q
V
L
T
P
I
Y
E
E
Q
F
H
D
H
S
Y
G
F
R
P
N
R
C
A
Q
Q
A
I
L
T
A
L
-
D
M
M
N
D
G
N
-
D
W
I
V
D
I
D
L
E
K
F
F
D
T
V
N
H
------------------------
D
K
L
M
-
T
I
I
-
G
R
T
---
I
K
D
G
D
V
I
S
I
V
R
K
Y
L
V
S
G
I
-
M
I
D
D
E
Y
E
D
S
I
------
V
--
G
T
P
Q
G
G
N
-
L
S
P
L
L
A
N
I
M
L
N
E
L
D
------------------------------------------------------------------
K
E
M
E
K
R
G
L
N
---
F
V
R
Y
A
D
D
C
I
I
M
-----------
V
G
-
S
E
M
S
A
N
R
V
M
R
N
I
S
R
F
I
-
E
E
K
L
G
L
K
V
N
M
T
K
S
K
V
--
D
R
----
P
R
G
I
K
Y
L
G
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
67.62
36%
-6
- C3 -
-
5HHJ
4
?
A:
[16-287]
------------------------------------------------------
S
S
L
M
E
Q
I
L
S
N
D
N
L
N
R
A
Y
L
Q
V
V
R
N
K
G
A
E
--
G
V
D
G
MKY
T
E
L
K
E
Y
L
A
K
N
G
E
I
I
K
E
Q
L
R
I
------
R
K
Y
K
P
Q
P
V
R
R
V
E
I
P
K
P
-
D
G
-
G
-
V
--
R
N
L
G
V
P
T
V
T
D
R
--
F
I
Q
Q
A
I
A
Q
V
L
T
P
I
Y
E
E
Q
F
H
D
H
S
Y
G
F
R
P
N
R
C
A
Q
Q
A
I
L
T
A
L
-
D
M
M
N
D
G
N
-
D
W
I
V
D
I
D
L
E
K
F
F
D
T
V
N
H
------------------------
D
K
L
M
-
T
I
I
-
G
R
T
---
I
K
D
G
D
V
I
S
I
V
R
K
Y
L
V
S
G
I
-
M
I
D
D
E
Y
E
D
S
I
------
V
--
G
T
P
Q
G
G
N
-
L
S
P
L
L
A
N
I
M
L
N
E
L
D
------------------------------------------------------------------
K
E
M
E
K
R
G
L
N
---
F
V
R
Y
A
D
D
C
I
I
M
-----------
V
G
-
S
E
M
S
A
N
R
V
M
R
N
I
S
R
F
I
-
E
E
K
L
G
L
K
V
N
M
T
K
S
K
V
--
D
R
----
P
R
G
I
K
Y
L
G
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
64.65
34%
24
- C3 -
-
5IRG
-
?
A:
[17-303]
-------------------------------------------------------
S
L
M
E
Q
I
L
S
N
D
N
L
N
R
A
Y
L
Q
V
V
R
N
K
G
A
E
--
G
V
D
G
MKY
T
E
L
K
E
Y
L
A
K
N
G
E
I
I
K
E
Q
L
R
I
------
R
K
Y
K
P
Q
P
V
R
R
V
E
I
P
K
P
-
D
G
-
G
-
V
---
N
L
G
V
P
T
V
T
D
R
--
F
I
Q
Q
A
I
A
Q
V
L
T
P
I
Y
E
E
Q
F
H
D
H
S
Y
G
F
R
P
N
R
C
A
Q
Q
A
I
L
T
A
L
-
D
M
M
N
D
G
N
-
D
W
I
V
D
I
D
L
E
K
F
F
D
T
V
N
H
------------------------
D
K
L
-
M
T
I
I
-
G
R
T
---
I
K
D
G
D
V
I
S
I
V
R
K
Y
L
V
S
G
I
M
I
D
D
---
E
Y
E
D
------
S
IV
G
T
P
Q
G
G
N
-
L
S
P
L
L
A
N
I
M
L
N
E
L
D
------------------------------------------------------------------
K
E
M
E
K
R
G
L
N
---
F
V
R
Y
A
D
D
C
I
I
M
-----------
V
G
-
S
E
M
S
A
N
R
V
M
R
N
I
S
R
F
I
-
E
E
K
L
G
L
K
V
N
M
T
K
S
K
V
--
D
R
----
P
R
G
I
K
Y
L
G
F
G
F
Y
Y
-
D
T
S
A
Q
-------
Q
F
K
A
K
P
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.21
34%
22
- C3 -
-
5HHK
2
?
A:
[16-303]
------------------------------------------------------
S
S
L
M
E
Q
I
L
S
N
D
N
L
N
R
A
Y
L
Q
V
V
R
N
K
G
A
E
--
G
V
D
G
MKY
T
E
L
K
E
Y
L
A
K
N
G
E
I
I
K
E
Q
L
R
I
------
R
K
Y
K
P
Q
P
V
R
R
V
E
I
P
K
P
-
D
G
-
G
-
V
--
R
N
L
G
V
P
T
V
T
D
R
--
F
I
Q
Q
A
I
A
Q
V
L
T
P
I
Y
E
E
Q
F
H
D
H
S
Y
G
F
R
P
N
R
C
A
Q
Q
A
I
L
T
A
L
-
D
M
M
N
D
G
N
-
D
W
I
V
D
I
D
L
E
K
F
F
D
T
V
N
H
------------------------
D
K
L
-
M
T
I
I
-
G
R
T
---
I
K
D
G
D
V
I
S
I
V
R
K
Y
L
V
S
G
I
M
I
D
D
---
E
Y
E
D
------
S
IV
G
T
P
Q
G
G
N
-
L
S
P
L
L
A
N
I
M
L
N
E
L
D
------------------------------------------------------------------
K
E
M
E
K
R
G
L
N
---
F
V
R
Y
A
D
D
C
I
I
M
-----------
V
G
-
S
E
M
S
A
N
R
V
M
R
N
I
S
R
F
I
-
E
E
K
L
G
L
K
V
N
M
T
K
S
K
V
--
D
R
----
P
R
G
I
K
Y
L
G
F
G
F
Y
Y
-
D
T
S
A
Q
-------
Q
F
K
A
K
P
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
62.38
31%
30
- C3 -
-
5G2X
1
LTRA_LACLC
C:
[4-591]
-------------------------
T
M
A
I
L
E
R
I
S
K
N
-------
S
Q
E
N
I
D
E
V
--
F
T
R
L
Y
R
Y
L
L
R
P
D
I
Y
Y
V
A
Y
Q
N
L
Y
S
N
---
K
G
A
S
T
K
G
---
I
L
D
D
T
A
D
G
F
S
E
E
K
I
K
K
I
I
Q
S
L
K
D
G
T
---
Y
Y
P
Q
P
V
R
R
M
Y
I
A
K
K
-
N
S
-
K
-
K
M-
R
P
L
G
I
P
T
F
T
D
K
--
L
I
Q
E
A
V
R
I
I
L
E
S
I
Y
E
P
V
F
E
D
V
S
H
G
F
R
P
Q
R
S
C
H
T
A
L
K
T
I
K
-
R
--
E
F
G
G
A
R
W
F
V
E
G
D
I
K
G
C
F
D
N
I
D
H
------------------------
V
T
L
I
G
-
L
I
-
N
L
K
---
I
K
D
M
K
M
S
Q
L
I
Y
K
F
L
K
A
G
-
Y
L
E
N
W
Q
Y
H
K
T
Y
------
S
--
G
T
P
Q
G
G
I
-
L
S
P
L
L
A
N
I
Y
L
H
E
L
D
K
--------
F
V
-----------------------------------------------
L
Q
L
K
M
K
F
D
R
E
S
P
E
R
I
T
P
E
K
Y
-
V
R
Y
A
D
D
F
I
I
S
-----------
V
K
G
S
K
E
D
C
Q
W
I
K
E
Q
L
K
L
F
I
-
H
N
K
L
K
M
E
L
S
E
E
K
T
L
I
T
H
-
S
----
S
Q
P
A
R
F
L
G
Y
D
I
R
V
-
V
K
K
R
T
LNGSV--
E
L
L
I
P
L
Q
---------------
D
K
I
R
Q
F
I
F
-
D
K
K
I
A
I
Q
K
K
D
S
S
W
F
--
P
------------
V
H
R
K
YLIRS
T
D
L
E
I
I
T
-
I
Y
N
S
E
L
R
G
I
C
N
Y
Y
G
L
A
S
N
--
F
N
Q
L
N
Y
F
A
Y
L
M
E
Y
S
C
L
K
T
I
A
-
S
K
H
K
G
T
L
S
K
T
I
S
M
F
K
D
G
S
G
S
-
W
G
----
I
P
Y
E
I
K
-------------------------------------------
Q
G
K
Q
---------
R
R
V
L
Y
G
Y
A
R
N
T
L
E
N
R
L
------------------
K
A
K
C
C
E
L
C
G
T
S
D
E
N
T
S
Y
E
I
H
H
V
-------------------------------------------------------------------
N
R
K
-
T
L
V
V
C
F
H
C
H
---------------------------------
19
HHSearch
56.79
27%
24
- C3 -
-
5G2X
1
LTRA_LACLC
C:
[8-591]
--------------------------------------
L
E
R
I
S
K
N
S
Q
E
N
I
D
EV
F
T
R
L
Y
R
Y
L
L
R
P
D
I
Y
Y
V
A
Y
Q
N
L
Y
S
N
---
K
G
A
S
T
K
G
---
I
L
D
D
T
A
D
G
F
S
E
E
K
I
K
K
I
I
Q
S
L
K
D
---
G
T
Y
Y
P
Q
P
V
R
R
M
Y
I
A
K
K
-
N
S
K
K
-
M
--
R
P
L
G
I
P
T
F
T
D
K
--
L
I
Q
E
A
V
R
I
I
L
E
S
I
Y
E
P
V
F
E
D
V
S
H
G
F
R
P
Q
R
S
C
H
T
A
L
K
T
I
K
-
R
E
F
G
--
G
A
R
W
F
V
E
G
D
I
K
G
C
F
D
N
I
D
H
------------------------
V
T
L
I
G
L
I
N
-
L
K
I
---
K
D
-
M
K
M
S
Q
L
I
Y
K
F
L
K
A
G
Y
L
E
N
W
-
Q
Y
H
K
T
Y
------
S
--
G
T
P
Q
G
G
I
-
L
S
P
L
L
A
N
I
Y
L
H
E
L
D
K
--------
F
V
---------
L
Q
L
K
M
K
F
D
R
E
S
P
ERITPE---------------------------------------
K
Y
V
R
Y
A
D
D
F
I
I
S
-----------
V
K
G
S
K
E
D
C
Q
W
I
K
E
Q
L
K
L
F
I
-
H
N
K
L
K
M
E
L
S
E
E
K
T
L
I
T
H
-
S
----
S
Q
P
A
R
F
L
G
Y
D
I
R
V
------VKKRTLN
G
S
V
E
L
L
I
---------------
P
L
Q
D
K
I
R
Q
-
F
I
F
----
D
K
K
I
A
I
Q
--
K
KDSSWFPVHRKY
L
I
R
S
-----
T
D
L
E
I
I
T
-
I
Y
N
S
E
L
R
G
I
C
N
Y
Y
G
L
A
S
N
F
N
-
Q
L
N
Y
F
A
Y
L
M
E
Y
S
C
L
K
T
I
A
S
-
K
H
K
G
T
---
L
S
K
T
I
--
S
M
F
K
D
G
S
G
----
S
W
G
---
I
P
Y
-
E
I
K
----
Q
G
K
Q
----------
R
R
---------------------------------------------
V
L
Y
G
Y
A
R
N
---
T
L
E
N
R
L
K
A
K
C
C
E
L
C
G
T
S
D
E
-
N
T
S
Y
E
I
H
H
V
N
---------------R
K
T
L
V
V
C
F
H
C
H
--------------------------------------------------------------------------------------
3
PsiBlast_PDB
51.13
32%
38
- C3 -
-
5G2X
1
LTRA_LACLC
C:
[21-491]
-------------------------------------------------
E
V
--
F
T
R
L
Y
R
Y
L
L
R
P
D
I
Y
Y
V
A
Y
Q
N
L
Y
S
N
K
G
A
S
T
K
G
-------
I
L
D
D
T
A
D
G
F
S
E
E
K
I
K
K
I
--
I
Q
S
L
K
D
G
T
Y
Y
P
Q
P
V
R
R
M
Y
I
A
K
K
-
N
S
-
K
K
M
--
R
P
L
G
I
P
T
F
T
D
K
--
L
I
Q
E
A
V
R
I
I
L
E
S
I
Y
E
P
V
F
E
D
V
S
H
G
F
R
P
Q
R
S
C
H
T
A
L
K
T
I
---
K
R
E
F
G
G
A
R
W
F
V
E
G
D
I
K
G
C
F
D
N
I
D
H
------------------------
V
T
L
I
G
L
I
--
N
L
K
---
I
K
D
M
K
M
S
Q
L
I
Y
K
F
L
K
A
G
Y
-
L
E
N
W
Q
Y
H
K
T
Y
------
S
--
G
T
P
Q
G
G
I
-
L
S
P
L
L
A
N
I
Y
L
H
E
L
D
K
--------
F
V
LQLKMKFDR
E
S
P
E
R
I
T
P
E
------------------------------------------------
K
Y
V
R
Y
A
D
D
F
I
I
S
-----------
V
K
G
S
K
E
D
C
Q
W
I
K
E
Q
L
K
L
F
I
-
H
N
K
L
K
M
E
L
S
E
E
K
T
L
I
T
H
S
S
----
Q
P
-
A
R
F
L
G
Y
D
I
R
V
--------------------VKKRTLNGSVELLIP
L
Q
D
K
I
R
Q
F
-
I
F
D
K
K
I
A
I
Q
K
K
D
S
S
WF
P
------------
V
H
R
K
YLIRS
T
D
L
E
I
I
T
-
I
Y
N
S
E
L
R
G
I
C
N
Y
Y
G
L
A
S
N
F
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
46.95
20%
-138
- C3 -
-
2FJX
1
A:
[119-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
Q
W
Y
T
V
L
D
L
K
D
A
F
F
C
L
R
L
------------------------
H
P
T
S
Q
P
L
F
-
A
F
E
---
W
R
D
P
-
E
M
G
I
-----------
S
G
---
Q
L
T
W
------
T
--
R
L
P
Q
G
F
K
-
N
S
P
T
L
F
D
E
A
L
H
R
D
L
A
--------
D
F
---------
R
I
Q
--------------------------------------------------
H
P
D
L
I
L
L
Q
Y
V
D
D
L
L
L
A
-----------
A
T
-
S
E
L
D
C
Q
Q
G
T
R
A
L
L
Q
T
L
-
G
-
N
L
G
Y
R
A
S
A
K
K
A
Q
I
C
Q
-------
K
Q
V
K
Y
L
G
Y
L
L
K
E
-
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
45.47
20%
-133
- C3 -
-
4XPC
4
A:
[123-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
Q
W
Y
T
V
L
D
L
K
D
A
F
F
C
L
R
L
------------------------
H
P
T
S
Q
P
L
F
-
A
F
E
---
W
R
D
P
-
E
--------------
S
G
---
Q
L
T
W
------
T
--
R
L
P
Q
G
F
K
-
N
S
P
T
L
F
D
E
A
L
H
R
D
L
A
--------
D
F
---------
R
I
Q
H
--------------------------------------------------
P
D
L
I
L
L
Q
Y
V
D
D
L
L
L
A
-----------
A
T
-
S
E
L
D
C
Q
Q
G
T
R
A
L
L
Q
T
L
-
G
-
N
L
G
Y
R
A
S
A
K
K
A
Q
I
C
Q
-------
K
Q
V
K
Y
L
G
Y
L
L
K
E
-
G
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
45.32
17%
22
* C2 *
-
5G0J
1
?
A:
[17-772]
VQGKS
K
A
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
--
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
---
E
E
L
K
T
L
A
E
K
Y
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
-
F
-
S
IN
R
P
P
G
H
H
A
Q
A
D
K
--
M
N
G
F
C
M
--
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
R
------
V
Q
R
V
L
I
V
D
W
-
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
EDGSFWPHLKESDSSSVGSGAGQ
G
Y
N
I
N
L
P
W
N
K
V
G
---
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
AGFDAV
I
--
G
D
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
Q
GR
L
V
L
A
L
---------
E
G
G
Y
N
L
Q
S
T
A
E
G
------
V
C
A
S
M
R
S
L
L
GDPCP
H
L
P
S
S
G
A
P
C
-
E
S
A
L
K
S
I
S
K
T
-
I
S
D
L
Y
--
P
F
W
K
S
L
Q
T
F
EGGPLSEVSP
L
P
A
-
P
V
C
A
E
V
K
V
S
S
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
S
H
H
P
E
L
P
----
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
-------
H
R
I
P
A
R
L
---------------
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
I
K
S
--
S
--
E
------------
H
M
K
P
-----
R
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
----
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
--
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
-
F
C
FFN
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
WDVHHG
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
-
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
M
G
D
P
E
Y
M
A
A
F
-
H
H
L
V
M
P
I
A
R
E
F
A
-------
P
E
L
V
L
V
S
A
G
FDAA
R
G
D
P
L
G
-
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
MSLAAGR
V
L
I
I
L
E
G
GYN
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
APFWSSLRVNIPESLRLSL
31
HHSearch
41.93
15%
-132
- C3 -
-
4OL8
-
YG31B_YEAST
B:
[145-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
Q
I
F
T
T
L
D
L
H
S
G
Y
H
Q
I
P
M
------------------------
E
P
K
D
R
Y
K
T
-
A
F
V
---
T
P
S
------------------
G
---
K
Y
E
Y
------
T
--
V
M
P
F
G
L
V
-
N
A
P
S
T
F
A
R
Y
M
A
D
T
F
R
--------
D
L
-----------------------------------------------------------------
R
F
V
N
V
Y
L
D
D
I
L
I
F
-----------
S
E
-
S
P
E
E
H
W
K
H
L
D
T
V
L
E
R
L
-
K
-
N
E
N
L
I
V
K
K
K
K
C
K
F
A
S
-------
E
E
T
E
F
L
G
Y
S
I
G
I
-
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
36.94
16%
-55
- C3 -
-
1T03
-
?
A:
[102-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
------------------------
D
E
D
F
R
K
Y
T
-
A
F
T
---
I
P
S
I
N
-----------
N
E
T
---
P
G
I
R
Y
Q
Y
------
N
--
V
L
P
Q
G
W
K
-
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
--------
P
F
---------
K
K
Q
--------------------------------------------------
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
-----------
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
-
L
-
R
W
G
L
T
T
P
D
K
K
H
Q
K
--------
E
P
P
F
L
W
M
G
Y
E
L
H
P
-
D
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
34.23
16%
12
- C3 -
-
3DU5
-
?
B:
[183-397]
----------------------------------------------------------------------------------------------------------------------------
V
L
N
I
I
P
K
Q
-
D
--
N
-
F
--
R
A
I
V
S
I
F
P
D
S
A
RK
P
F
F
K
L
L
T
S
K
I
Y
K
V
L
E
E
------
K
Y
K
T
S
-
G
S
L
Y
T
C
W
S
E
F
T
-
Q
K
T
Q
--
G
Q
I
Y
G
I
K
V
D
I
R
D
A
Y
G
N
V
K
I
------------------------
P
V
L
C
K
L
I
Q
-
S
I
P
THL
L
D
S
E
-
K
K
N
F
I
V
D
H
I
S
N
Q
F
V
A
F
R
R
K
I
Y
K
W
N
------
H
--
G
L
L
Q
G
D
P
-
L
S
G
C
L
C
E
L
Y
M
A
F
M
D
R
--------
L
Y
---------
F
S
N
L
-------------------------------------------------
D
K
D
A
F
I
H
R
T
V
D
D
Y
F
F
C
-----------
S
P
-
H
P
H
K
V
Y
D
F
-----
E
L
L
-
I
-
K
G
V
Y
Q
V
N
P
T
K
T
R
T
N
L
P
T
HRHP
Q
D
E
I
P
Y
C
G
K
I
F
N
L
-
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
33.86
13%
-49
- C4 -
-
3MKT
-
?
A:
[2-461]
------------------------------------
E
N
S
V
H
R
Y
K
K
E
A
S
N
L
I
--
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
I
M
A
G
G
V
S
A
I
D
M
A
A
---
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
V
G
L
--
L
M
A
L
V
P
V
-----------
V
A
Q
L
-
N
G
-
A
-
G
--
R
Q
H
K
I
P
F
E
V
H
Q
--
G
L
I
L
A
L
L
V
S
V
P
I
I
A
V
L
F
Q
T
Q
F
I
I
R
F
M
D
V
E
E
A
M
A
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
P
A
Y
L
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
------------------------
T
K
P
A
-------------
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
------
L
--
G
G
V
G
C
G
V
-
A
T
A
I
V
Y
W
I
M
L
L
L
L
L
F
--------
Y
I
---------
V
T
S
K
R
L
A
----------------------------------
H
V
K
V
F
E
T
F
H
K
P
Q
P
K
E
L
I
R
L
F
R
L
G
F
P
V
A
A
-----------
A
L
-
F
F
E
V
T
L
F
A
V
V
A
L
L
------------
V
A
P
L
G
S
T
V
V
A
A
----
H
Q
V
A
L
N
F
S
S
L
V
F
M
-
F
P
M
S
I
-------
G
A
A
V
S
I
R
---------------
V
G
H
K
L
G
E
Q
-
D
T
K
G
A
------------------------------------------
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
V
V
V
A
L
A
M
Q
L
L
L
F
A
A
I
Y
Q
C
M
D
A
V
Q
-
V
V
----
A
A
G
S
L
R
G
Y
K
D
---------------------------------------
M
T
A
I
F
H
R
T
F
I
S
Y
W
V
L
G
L
P
T
G
Y
I
L
G
M
T
N
----------------------------------------
W
L
T
E
Q
P
L
G
----
A
K
G
F
W
L
-
G
F
I
I
G
L
S
A
A
A
L
M
L
G
Q
--------------------
R
L
Y
W
L
Q
K
Q
S
D
D
V
Q
L
H
L
A
A
-
K
-----------------------------------------
23
HHSearch
33.74
16%
35
- C3 -
-
5CQG
-
?
A:
[183-397]
----------------------------------------------------------------------------------------------------------------------------
V
L
N
I
I
P
K
Q
-
D
--
N
-
F
--
R
A
I
V
S
I
F
P
D
S
A
R
K
P
F
F
K
L
L
T
S
K
I
Y
K
V
L
E
E
------
K
Y
K
T
S
-
G
S
L
Y
T
C
W
S
E
F
T
-
Q
K
T
Q
--
G
Q
I
Y
G
I
K
V
D
I
R
D
A
Y
G
N
V
K
I
------------------------
P
V
L
C
K
L
I
Q
-
S
I
P
THL
L
D
S
E
-
K
K
N
F
I
V
D
H
I
S
N
Q
F
V
A
F
R
R
K
I
Y
K
W
N
------
H
--
G
L
L
Q
G
D
P
-
L
S
G
C
L
C
E
L
Y
M
A
F
M
D
R
--------
L
Y
---------
F
S
N
L
-------------------------------------------------
D
K
D
A
F
I
H
R
T
V
D
D
Y
F
F
C
-----------
S
P
-
H
P
H
K
V
Y
D
F
-----
E
L
L
-
I
-
K
G
V
Y
Q
V
N
P
T
K
T
R
T
N
L
P
T
HRHP
Q
D
E
I
P
Y
C
G
K
I
F
N
L
-
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
33.61
10%
-116
- C3 -
-
5X42
-
?
A:
[22-84]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
R
F
K
S
Y
E
Q
---
K
I
F
Q
R
D
-
R
Y
T
C
Q
F
C
G
F
Q
A
----
A
L
Y
Q
D
I
V
N
L
D
G
D
Y
----
T
N
N
R
L
S
-
N
L
V
T
A
C
C
F
C
A
Q
C
F
F
V
--------------------
E
S
V
----------------------------------------------------------