@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XY17: (2018-01-07 )
MAQRTIYCGLVSEQQLEQTVTLKGWVQKRRDLGGVIFIDLRDREGIVQIVFNPEINKEAWEIADKCRSEYVIEVTGEVRRRGENAVNPKMATGEFEVIASEIVILNQAKTPPFQIEDDQAISDEIRLKYRYLDLRRPKMTKNIKLRNATTKAIRHYLDDNDFLDIETPYLGKSTPEGARDYLVPSRVHAGHFYALPQSPQLFKQLLMNAGFDRYYQIVRCFRDEDLRGDRQPEFTQVDIETTFLTAEEIQTYTEGLIAKVMKEVRGIEVTLPFPRMTYDEAMARYGSDKPDTRFDMELIDLSDTVKEVEFKVFQMALENGGVVKALNAKGAADRYSRKDMDQLGQYVGQFGAKGLAWLKVEEDGLKGPIAKFMGEATEAIIKATDAKPGDLLMFGADKSEIVAAALGAIRTRLGKELGLIDESKFNFLWVTDWPQFEFSEEEGRYVSAHHPFTMPKEEDIPLLAEDPAKVYAEAYDIVLNGYELGGGSIRIHTRELQEKVLETLGFTKEQMEEQFGFLLTALDYGFPPHGGIALGLDRFAMLLAGEDNIREVIAFPKNGKAADVMSDAPSMVSPLQLFELNIDVTNIEE
Atome Classification :
(23 SA)
.........10........20........30........40........50-........60........70........80........90........100.......110.....------.--.----.120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230........240...-....250.......260.....-------------..270.......280.......290.......300.......310..-....-.-320.......330.......340.......350.......360-----..-----.....370.-..-.-.-.-.380.......390.......400.......410.......420.......430.......440---------........450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAQR
T
I
Y
C
GLV
S
E
Q
Q
L
E
Q
T
V
T
L
K
G
W
V
Q
K
R
RDLG
G
V
I
F
I
D
LRDRE
G
I
V
Q
I
V
F-NPEI
N
K
E
A
W
E
I
A
D
K
CRS
E
Y
V
I
E
V
T
G
E
V
R
RRGENAVNPKMATG
E
F
E
V
I
A
S
E
I
V
I
L
NQAKTP-
P
F
QIE------D--D----QAI
S
D
E
I
R
L
K
Y
R
Y
L
DLRRPKMTK
N
I
K
LRNA
T
T
K
A
I
R
H
Y
LDDN
D
F
L
DIETPYLGKSTPEGARDYLVPSRVHA
G
H
F
YALPQ
S
P
Q
L
F
K
Q
L
L
M
NA
G
F
D
R
Y
Y
Q
I
V
R
C
F
RDEDLRGDRQ-PE
F
T
Q
V
D
I
E
T
T
F
L
T
-
A
E
E
I
Q
T
Y
T
E
G
L
I
A
K
V
M
K
E
VRG
I
-------------
E
V
T
LPFPRM
T
Y
D
E
A
M
A
RYGSDKPDTRF
D
M
E
L
IDL
S
D
T
V
K
E
V
E
F
K
V
F
Q
-
M
A
L
E-N-G
G
V
V
K
A
LNAKGAADRY
S
R
K
D
M
D
Q
L
G
Q
Y
V
G
QFGAK
G
L
A
W
L
K
VEE-----DG-----LK
G
P
I
A
K
F
M
-
G
E
-
A
-
T
-
E
-
A
I
I
KATDAKPG
D
L
L
M
FGA
D
K
S
E
I
V
A
A
A
L
G
A
I
R
T
R
L
G
K
ELGLIDESK
F
N
F
L
W
VTDWPQFEFSEE----------EG
R
Y
V
SAHHPFTMPKEEDIPLLAED
P
A
K
V
Y
A
E
A
Y
D
I
V
L
N
G
Y
E
LGG
G
S
I
R
I
H
T
R
E
L
Q
E
K
V
L
E
T
LGF
T
K
E
Q
M
E
E
Q
F
G
F
L
L
T
A
L
DYGFPPHG
G
I
A
L
G
L
D
R
F
A
M
L
LAGED
N
I
R
E
V
IAFPKNGKA
A
D
V
MSDAPSMVS
P
L
Q
L
F
E
L
N
I
D
VTNIEE
41
HHSearch
84.80
55%
-14
- C7 -
-
1C0A
2
SYD_ECOLI
A:
[1-584]
--
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
-
D
P
D
R
-
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
D
V
L
-
P
L
D
S
N
--------------
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
T
-
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
-------------
D
-
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
-
G
P
A
N
D
P
-
K
G
R
V
A
A
L
R
V
P
G
G
A
-
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGL
E
G
-----
I
N
S
P
V
A
K
F
L
-
N
A
E
I
-
I
-
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
D
D
G
-----------
E
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
----
21
PsiBlast_CBE
84.70
53%
-11
- C7 -
-
1IL2
1
SYD_ECOLI
B:
[2-585]
---
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
-
D
P
D
-
R
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
D
V
L
-
P
--
L
D
------
S
--
N
----
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
T
-
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
-------------
D
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
-
P
-
K
G
R
V
A
A
L
R
V
P
G
G
A
S
-
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGL
E
G
-----
I
N
S
P
V
A
K
F
L
N
A
E
-
I
-
I
-
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
-
D
D
G
----------
E
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
---
2
PsiBlast_PDB
84.57
53%
-11
- C7 -
-
1IL2
1
SYD_ECOLI
A:
[2-585]
---
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
-
D
P
D
-
R
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
D
V
L
-
P
--
L
D
------
S
--
N
----
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
T
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A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
-------------
D
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
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F
A
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F
A
G
P
A
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-
P
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K
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A
A
L
R
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G
A
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L
T
R
K
Q
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D
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Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGL
E
G
-----
I
N
S
P
V
A
K
F
L
N
A
E
-
I
-
I
-
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
-
D
D
G
----------
E
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
---
43
HHSearch
84.54
54%
-
- C7 -
-
4WJ3
-
SYDND_PSEAE
O:
[2-588]
--
M
R
S
H
Y
C
G
Q
L
N
E
S
L
D
G
Q
E
V
T
L
C
G
W
V
H
R
R
R
D
H
G
G
V
I
F
L
D
V
R
D
R
E
G
L
A
Q
V
V
F
-
D
P
D
R
A
-
E
T
F
A
K
A
D
R
V
R
S
E
F
V
V
K
I
T
G
K
V
R
L
R
P
E
G
A
R
N
P
N
M
A
S
G
S
I
E
V
L
G
Y
E
L
E
V
L
N
Q
A
E
T
P
-
P
F
P
L
D
------
E
--
Y
----
S
D
V
G
E
E
T
R
L
R
Y
R
F
I
D
L
R
R
P
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
L
D
D
N
G
F
L
D
V
E
T
P
I
L
G
R
P
T
P
E
G
A
R
D
Y
L
V
P
S
R
T
Y
P
G
H
F
F
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
F
D
R
Y
Y
Q
I
A
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
I
E
T
S
F
L
D
-
E
S
D
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
E
V
L
D
V
-------------
E
-
F
D
E
F
P
H
M
P
F
E
E
A
M
R
R
Y
G
S
D
K
P
D
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
F
S
-
G
P
A
N
D
P
-
K
G
R
V
A
A
L
R
V
P
G
A
A
-
S
M
P
R
S
Q
I
D
D
Y
T
K
F
V
G
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGV
E
G
-----
L
Q
S
P
I
V
K
F
I
-
P
E
A
N
-
L
-
N
-
V
I
L
D
R
V
G
A
V
D
G
D
I
V
F
F
G
A
D
K
A
K
I
V
C
D
A
L
G
A
L
R
I
K
V
G
H
D
L
K
L
L
T
-
R
E
W
A
P
M
W
V
V
D
F
P
M
F
E
E
N
D
-----------
D
G
S
L
S
A
L
H
H
P
F
T
S
P
K
C
T
P
-
A
E
L
E
A
N
P
G
A
A
L
S
R
A
Y
D
M
V
L
N
G
T
E
L
G
G
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
L
G
I
D
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
K
Y
G
A
P
P
H
G
G
L
A
F
G
L
D
R
L
V
M
L
M
T
G
A
S
S
I
R
E
V
I
A
F
P
K
T
Q
S
A
G
D
V
M
T
Q
A
P
G
S
V
D
G
K
A
L
R
E
L
H
I
R
L
R
E
Q
P
-
3
PsiBlast_PDB
84.53
53%
-11
- C7 -
-
1C0A
2
SYD_ECOLI
A:
[2-584]
---
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
-
D
P
D
-
R
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
D
V
L
-
P
--
L
D
------
S
--
N
----
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
T
-
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
-------------
D
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
-
P
-
K
G
R
V
A
A
L
R
V
P
G
G
A
S
-
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGL
E
G
-----
I
N
S
P
V
A
K
F
L
N
A
E
-
I
-
I
-
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
-
D
D
G
----------
E
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
----
1
PsiBlast_PDB
84.53
53%
-13
- C7 -
-
1EQR
-
SYD_ECOLI
A:
[2-588]
---
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
-
D
P
D
-
R
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
D
V
L
-
P
--
L
D
------
S
--
N
----
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
T
-
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
-------------
D
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
-
P
-
K
G
R
V
A
A
L
R
V
P
G
G
A
S
-
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGL
E
G
-----
I
N
S
P
V
A
K
F
L
N
A
E
-
I
-
I
-
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
-
D
D
G
----------
E
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
K
A
E
62
Fugue
84.27
54%
-11
- C7 -
-
1C0A
2
SYD_ECOLI
A:
[1-585]
--
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
-
D
P
D
-
R
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
D
V
L
-
P
L
D
S
N
------
H
--
V
----
N
--
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
T
-
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
-------------
D
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
-
G
P
A
N
-
D
P
K
G
R
V
A
A
L
R
V
P
G
G
A
S
-
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
-----
R
A
KGLEG
I
N
S
P
V
A
K
F
L
N
A
E
-
I
-
I
-
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
D
-
D
G
----------
E
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
---
4
PsiBlast_PDB
84.16
53%
-
- C7 -
-
4WJ3
-
SYDND_PSEAE
M:
[3-582]
---
R
S
H
Y
C
G
Q
L
N
E
S
L
D
G
Q
E
V
T
L
C
G
W
V
H
R
R
R
D
H
G
G
V
I
F
L
D
V
R
D
R
E
G
L
A
Q
V
V
F
-
D
P
D
-
R
A
E
T
F
A
K
A
D
R
V
R
S
E
F
V
V
K
I
T
G
K
V
R
L
R
P
E
G
A
R
N
P
N
M
A
S
G
S
I
E
V
L
G
Y
E
L
E
V
L
N
Q
A
E
T
P
-
P
F
P
L
D
------
E
--
Y
----
S
D
V
G
E
E
T
R
L
R
Y
R
F
I
D
L
R
R
P
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
L
D
D
N
G
F
L
D
V
E
T
P
I
L
G
R
P
T
P
E
G
A
R
D
Y
L
V
P
S
R
T
Y
P
G
H
F
F
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
F
D
R
Y
Y
Q
I
A
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
I
E
T
S
F
L
D
-
E
S
D
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
E
V
L
D
V
-------------
E
F
D
-
E
F
P
H
M
P
F
E
E
A
M
R
R
Y
G
S
D
K
P
D
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
F
S
G
P
A
N
D
-
P
-
K
G
R
V
A
A
L
R
V
P
G
A
A
S
-
M
P
R
S
Q
I
D
D
Y
T
K
F
V
G
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGV
E
G
-----
L
Q
S
P
I
V
K
F
I
-
P
E
-
A
-
N
L
N
-
V
I
L
D
R
V
G
A
V
D
G
D
I
V
F
F
G
A
D
K
A
K
I
V
C
D
A
L
G
A
L
R
I
K
V
G
H
D
L
K
L
L
T
R
-
E
W
A
P
M
W
V
V
D
F
P
M
F
E
-
E
N
D
----------
D
G
S
L
S
A
L
H
H
P
F
T
S
P
K
C
T
P
A
E
L
E
A
-
N
P
G
A
A
L
S
R
A
Y
D
M
V
L
N
G
T
E
L
G
G
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
L
G
I
D
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
K
Y
G
A
P
P
H
G
G
L
A
F
G
L
D
R
L
V
M
L
M
T
G
A
S
S
I
R
E
V
I
A
F
P
K
T
Q
S
A
G
D
V
M
T
Q
A
P
G
S
V
D
G
K
A
L
R
E
L
H
I
-------
42
HHSearch
84.00
54%
-22
- C7 -
-
4WJ4
1
SYDND_PSEAE
A:
[10-594]
--
M
R
S
H
Y
C
G
Q
L
N
E
S
L
D
G
Q
E
V
T
L
C
G
W
V
H
R
R
R
D
H
G
G
V
I
F
L
D
V
R
D
R
E
G
L
A
Q
V
V
F
-
D
P
D
R
A
-
E
T
F
A
K
A
D
R
V
R
S
E
F
V
V
K
I
T
G
K
V
R
L
R
P
E
G
A
R
N
P
N
M
A
S
G
S
I
E
V
L
G
Y
E
L
E
V
L
N
Q
A
E
T
P
-
P
F
P
L
D
------
E
--
Y
----
S
D
V
G
E
E
T
R
L
R
Y
R
F
I
D
L
R
R
P
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
L
D
D
N
G
F
L
D
V
E
T
P
I
L
G
R
P
T
P
E
G
A
R
D
Y
L
V
P
S
R
T
Y
P
G
H
F
F
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
F
D
R
Y
Y
Q
I
A
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
I
E
T
S
F
L
D
-
E
S
D
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
E
V
L
D
V
-------------
E
-
F
D
E
F
P
H
M
P
F
E
E
A
M
R
R
Y
G
S
D
K
P
D
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
F
S
-
G
P
A
N
D
P
-
K
G
R
V
A
A
L
R
V
P
G
A
A
-
S
M
P
R
S
Q
I
D
D
Y
T
K
F
V
G
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGV
E
G
-----
L
Q
S
P
I
V
K
F
I
-
P
E
A
N
-
L
-
N
-
V
I
L
D
R
V
G
A
V
D
G
D
I
V
F
F
G
A
D
K
A
K
I
V
C
D
A
L
G
A
L
R
I
K
V
G
H
D
L
K
L
L
T
-
R
E
W
A
P
M
W
V
V
D
F
P
M
F
E
E
N
D
-----------
D
G
S
L
S
A
L
H
H
P
F
T
S
P
K
C
T
P
-
A
E
L
E
A
N
P
G
A
A
L
S
R
A
Y
D
M
V
L
N
G
T
E
L
G
G
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
L
G
I
D
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
K
Y
G
A
P
P
H
G
G
L
A
F
G
L
D
R
L
V
M
L
M
T
G
A
S
S
I
R
E
V
I
A
F
P
K
T
Q
S
A
G
D
V
M
T
Q
A
P
G
S
V
D
G
K
A
L
R
E
L
H
I
R
L
R
E
---
5
PsiBlast_PDB
83.40
53%
-21
- C7 -
-
4WJ4
1
SYDND_PSEAE
A:
[11-590]
---
R
S
H
Y
C
G
Q
L
N
E
S
L
D
G
Q
E
V
T
L
C
G
W
V
H
R
R
R
D
H
G
G
V
I
F
L
D
V
R
D
R
E
G
L
A
Q
V
V
F
-
D
P
D
-
R
A
E
T
F
A
K
A
D
R
V
R
S
E
F
V
V
K
I
T
G
K
V
R
L
R
P
E
G
A
R
N
P
N
M
A
S
G
S
I
E
V
L
G
Y
E
L
E
V
L
N
Q
A
E
T
P
-
P
F
P
L
D
------
E
--
Y
----
S
D
V
G
E
E
T
R
L
R
Y
R
F
I
D
L
R
R
P
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
L
D
D
N
G
F
L
D
V
E
T
P
I
L
G
R
P
T
P
E
G
A
R
D
Y
L
V
P
S
R
T
Y
P
G
H
F
F
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
F
D
R
Y
Y
Q
I
A
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
I
E
T
S
F
L
D
-
E
S
D
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
E
V
L
D
V
-------------
E
F
D
-
E
F
P
H
M
P
F
E
E
A
M
R
R
Y
G
S
D
K
P
D
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
F
S
G
P
A
N
D
-
P
-
K
G
R
V
A
A
L
R
V
P
G
A
A
S
-
M
P
R
S
Q
I
D
D
Y
T
K
F
V
G
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGV
E
G
-----
L
Q
S
P
I
V
K
F
I
-
P
E
-
A
-
N
L
N
-
V
I
L
D
R
V
G
A
V
D
G
D
I
V
F
F
G
A
D
K
A
K
I
V
C
D
A
L
G
A
L
R
I
K
V
G
H
D
L
K
L
L
T
R
-
E
W
A
P
M
W
V
V
D
F
P
M
F
E
-
E
N
D
----------
D
G
S
L
S
A
L
H
H
P
F
T
S
P
K
C
T
P
A
E
L
E
A
-
N
P
G
A
A
L
S
R
A
Y
D
M
V
L
N
G
T
E
L
G
G
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
L
G
I
D
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
K
Y
G
A
P
P
H
G
G
L
A
F
G
L
D
R
L
V
M
L
M
T
G
A
S
S
I
R
E
V
I
A
F
P
K
T
Q
S
A
G
D
V
M
T
Q
A
P
G
S
V
D
G
K
A
L
R
E
L
H
I
-------
11
PsiBlast_PDB
80.89
47%
-38
- C7 -
-
5W25
5
?
A:
[25-604]
---
R
S
H
A
A
G
L
L
R
E
G
D
A
G
Q
Q
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
I
A
Q
V
V
F
-
R
D
P
Q
D
T
E
V
L
A
Q
A
H
R
L
R
A
E
F
C
V
S
V
A
G
V
V
E
I
R
P
E
G
N
A
N
P
E
I
A
T
G
E
I
E
V
N
A
T
S
L
T
V
L
G
E
C
A
P
L
-
P
F
Q
L
----------
D
----
E
P
A
G
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
D
D
P
A
A
A
I
R
L
R
S
R
V
N
A
A
A
R
A
V
L
A
R
H
D
F
V
E
I
E
T
P
T
I
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
H
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
R
A
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
D
-
A
E
D
I
I
A
I
S
E
E
V
L
T
E
L
W
A
L
I
-
G
Y
-------------
R
I
P
T
P
I
P
R
I
G
Y
A
E
A
M
R
R
F
G
T
D
K
P
D
L
R
F
G
L
E
L
V
E
C
T
D
F
F
S
D
T
T
F
R
V
F
Q
-
A
P
Y
-------
V
G
A
V
V
M
P
G
G
A
S
Q
-
P
R
R
T
L
D
G
W
Q
D
W
A
K
Q
R
G
H
R
G
L
A
Y
V
L
V
A
E
-----
D
G
T
----
L
G
G
P
V
A
K
N
L
-
T
E
-
A
-
E
-
R
T
G
L
A
D
H
V
G
A
K
P
G
D
C
I
F
F
S
A
G
P
V
K
S
S
R
A
L
L
G
A
A
R
V
E
I
A
N
R
L
G
L
I
D
P
D
A
W
A
F
V
W
V
V
D
P
P
L
F
E
P
A
D
E
A
T
A
A
GEVAVG
S
G
A
W
T
A
V
H
H
A
F
T
A
P
K
P
E
W
E
D
R
I
E
S
D
T
G
S
V
L
A
D
A
Y
D
I
V
C
N
G
H
E
I
G
G
G
S
V
R
I
H
R
R
D
I
Q
E
R
V
F
A
V
M
G
L
D
K
A
E
A
E
E
K
F
G
F
L
L
E
A
F
M
F
G
A
P
P
H
G
G
I
A
F
G
W
D
R
T
T
A
L
L
A
G
M
D
S
I
R
E
V
I
A
F
P
K
T
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
A
Q
Q
R
K
E
S
---------
9
PsiBlast_PDB
80.88
46%
-36
- C7 -
-
4O2D
3
SYDND_MYCS2
A:
[23-604]
-
V
L
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
-
R
---
E
G
D
V
L
A
A
A
H
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
A
P
L
-
P
F
Q
L
-------
D
--
E
----
Q
A
-
G
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
--
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
E
-
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
T
I
-
G
Y
-------------
D
L
P
L
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
K
D
T
T
F
R
V
F
Q
-
A
P
Y
-------
V
G
A
V
V
M
P
G
G
A
S
Q
-
P
R
R
T
L
D
G
W
Q
E
F
A
K
Q
R
G
H
K
G
L
A
Y
V
L
V
G
E
-----
D
G
T
----
L
G
G
P
V
A
K
N
L
-
S
D
-
A
E
R
-
D
-
G
L
V
A
H
V
G
A
N
P
G
D
C
I
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
L
I
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
E
A
A
D
E
A
T
A
A
GDVAVG
S
G
A
W
T
A
M
H
H
A
F
T
A
P
K
P
D
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
I
D
------
39
HHSearch
80.39
47%
-36
- C7 -
-
4RMF
2
SYDND_MYCS2
A:
[2-580]
--
L
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
-
R
E
G
D
---
V
L
A
A
A
H
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
A
P
L
-
P
F
Q
L
D
------
E
--------
Q
A
G
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
R
A
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
E
-
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
T
I
G
-
Y
-------------
D
L
P
L
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
K
D
T
T
F
R
V
F
Q
--------
A
P
Y
V
G
A
V
V
M
P
G
G
A
-
S
Q
P
R
R
T
L
D
G
W
Q
E
F
A
K
Q
R
G
H
K
G
L
A
Y
V
L
V
G
E
D----
G
T
-----
L
G
G
P
V
A
K
N
L
-
S
D
A
E
-
R
-
D
-
G
L
V
A
H
V
G
A
N
P
G
D
C
I
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
L
I
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
E
A
A
D
E
ATAAGDVAVG
S
G
A
W
T
A
M
H
H
A
F
T
A
P
K
P
D
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
--------
7
PsiBlast_PDB
79.69
51%
23
- C7 -
-
1G51
1
SYD_THETH
A:
[2-579]
--
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
-
H
P
--
A
S
P
A
Y
A
T
A
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
K
T
P
-
P
F
P
V
D
AGWRG
E
E
--
E
----
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
E
-
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
-------------
E
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
-
E
A
E
S
------
V
K
A
L
A
L
P
K
A
---
L
S
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
-----
F
S
G
G
V
A
K
F
L
-
E
P
-
V
-
R
-
E
-
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
L
K
R
E
G
-
F
R
F
L
W
V
V
D
F
P
L
L
E
W
D
E
E
----------
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
---
10
PsiBlast_PDB
79.49
46%
-34
- C7 -
-
4RMF
2
SYDND_MYCS2
A:
[3-580]
---
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
-
R
---
E
G
D
V
L
A
A
A
H
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
A
P
L
-
P
F
Q
L
-------
D
--
E
----
Q
A
-
G
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
R
A
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
E
-
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
T
I
-
G
Y
-------------
D
L
P
L
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
K
D
T
T
F
R
V
F
Q
-
A
P
Y
-------
V
G
A
V
V
M
P
G
G
A
S
Q
-
P
R
R
T
L
D
G
W
Q
E
F
A
K
Q
R
G
H
K
G
L
A
Y
V
L
V
G
E
-----
D
G
T
----
L
G
G
P
V
A
K
N
L
-
S
D
-
A
E
R
-
D
-
G
L
V
A
H
V
G
A
N
P
G
D
C
I
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
L
I
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
E
A
A
D
E
ATAAGDVAVG
S
G
A
W
T
A
M
H
H
A
F
T
A
P
K
P
D
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
--------
44
HHSearch
79.42
53%
23
- C7 -
-
1L0W
-
B:
[1001-1579]
-
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
-
H
P
A
S
--
P
A
Y
A
T
A
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
K
T
P
-
P
F
P
V
D
------
A
GW
R
GEEE
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
E
-
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
-------------
E
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
------
E
-
A
E
S
V
K
A
L
A
L
P
K
A
---
L
S
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
-----
F
S
G
G
V
A
K
F
L
-
E
P
-
V
-
R
-
E
-
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
L
K
R
-
E
G
F
R
F
L
W
V
V
D
F
P
L
L
E
W
D
E
E
----------
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
---
24
PsiBlast_CBE
79.40
51%
25
- C7 -
-
1G51
2
SYD_THETH
B:
[2-579]
--
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
-
H
P
--
A
S
P
A
Y
A
T
A
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
K
T
P
-
P
F
P
V
D
AGWRGE
E
--
E
----
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
E
-
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
-------------
E
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
-
E
A
E
S
------
V
K
A
L
A
L
P
K
A
---
L
S
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
-----
F
S
G
G
V
A
K
F
L
-
E
P
-
V
-
R
-
E
-
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
L
K
R
E
G
-
F
R
F
L
W
V
V
D
F
P
L
L
E
W
D
E
E
----------
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
---
8
PsiBlast_PDB
79.24
51%
26
- C7 -
-
1L0W
-
SYD_THETH
A:
[2-579]
--
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
-
H
P
--
A
S
P
A
Y
A
T
A
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
K
T
P
-
P
F
P
V
D
AGWRG
E
E
--
E
----
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
E
-
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
-------------
E
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
-
E
A
E
S
------
V
K
A
L
A
L
P
K
A
---
L
S
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
-----
F
S
G
G
V
A
K
F
L
-
E
P
-
V
-
R
-
E
-
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
L
K
R
E
G
-
F
R
F
L
W
V
V
D
F
P
L
L
E
W
D
E
E
----------
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
---
6
PsiBlast_PDB
78.78
51%
29
- C7 -
-
1EFW
-
SYD_THETH
A:
[2-579]
--
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
-
H
P
--
A
S
P
A
Y
A
T
A
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
K
T
P
-
P
F
P
V
D
AGWRGE
E
--
E
----
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
E
-
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
-------------
E
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
-
E
A
E
S
------
V
K
A
L
A
L
P
K
A
---
L
S
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
-----
F
S
G
G
V
A
K
F
L
-
E
P
-
V
-
R
-
E
-
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
L
K
R
E
G
-
F
R
F
L
W
V
V
D
F
P
L
L
E
W
D
E
E
----------
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
---
45
HHSearch
78.59
53%
26
- C7 -
-
1EFW
-
SYD_THETH
B:
[1-579]
-
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
-
H
P
A
S
--
P
A
Y
A
T
A
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
K
T
P
-
P
F
P
V
D
------
A
GW
R
GEEE
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
E
-
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
-------------
E
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
------
E
-
A
E
S
V
K
A
L
A
L
P
K
A
---
L
S
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
-----
F
S
G
G
V
A
K
F
L
-
E
P
-
V
-
R
-
E
-
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
L
K
R
-
E
G
F
R
F
L
W
V
V
D
F
P
L
L
E
W
D
E
E
----------
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
---
26
PsiBlast_CBE
77.31
47%
-36
- C7 -
-
5W25
5
?
B:
[25-604]
---
R
S
H
A
A
G
L
L
R
E
G
D
A
G
Q
Q
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
I
A
Q
V
V
F
-
R
D
P
Q
D
T
E
V
L
A
Q
A
H
R
L
R
A
E
F
C
V
S
V
A
G
V
V
E
I
R
P
E
G
N
A
N
P
E
I
A
T
G
E
I
E
V
N
A
T
S
L
T
V
L
G
E
C
A
P
L
-
P
F
Q
L
----------
D
----
E
P
A
G
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
D
D
P
A
A
A
I
R
L
R
S
R
V
N
A
A
A
R
A
V
L
A
R
H
D
F
V
E
I
E
T
P
T
I
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
H
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
R
A
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
D
-
A
E
D
I
I
A
I
S
E
E
V
L
T
E
L
W
A
L
I
-
G
Y
-------------
R
I
P
T
P
I
P
R
I
G
Y
A
E
A
M
R
R
F
G
T
D
K
P
D
L
R
F
G
L
E
L
V
E
C
T
D
F
F
S
D
T
T
F
R
V
F
Q
-
A
P
Y
-------
V
G
A
V
V
M
P
G
G
A
S
Q
-
P
R
-----------------
L
A
Y
V
L
V
A
E
-----
D
G
T
----
L
G
G
P
V
A
K
N
L
-
T
E
-
A
-
E
-
R
T
G
L
A
D
H
V
G
A
K
P
G
D
C
I
F
F
S
A
G
P
V
K
S
S
R
A
L
L
G
A
A
R
V
E
I
A
N
R
L
G
L
I
D
P
D
A
W
A
F
V
W
V
V
D
P
P
L
F
E
P
A
D
E
A
T
A
A
GEVAVG
S
G
A
W
T
A
V
H
H
A
F
T
A
P
K
P
E
W
E
D
R
I
E
S
D
T
G
S
V
L
A
D
A
Y
D
I
V
C
N
G
H
E
I
G
G
G
S
V
R
I
H
R
R
D
I
Q
E
R
V
F
A
V
M
G
L
D
K
A
E
A
E
E
K
F
G
F
L
L
E
A
F
M
F
G
A
P
P
H
G
G
I
A
F
G
W
D
R
T
T
A
L
L
A
G
M
D
S
I
R
E
V
I
A
F
P
K
T
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
A
Q
Q
R
K
E
S
---------
25
PsiBlast_CBE
72.48
46%
-37
- C7 -
-
4O2D
3
SYDND_MYCS2
B:
[23-604]
-
V
L
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
-
R
---
E
G
D
V
L
A
A
A
H
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
A
P
L
-
P
F
Q
L
-------
D
--
E
----
Q
A
-
G
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
--
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
E
-
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
T
I
-
G
Y
-------------
D
L
P
L
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
-----------
P
Y
-------
V
G
A
V
V
M
P
-------------
W
Q
E
F
A
K
Q
R
G
--------------------------------------------------------
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
L
I
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
E
A
A
D
E
A
T
A
A
GDVAVG
S
G
A
W
T
A
M
H
H
A
F
T
A
P
K
P
D
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
I
D
------
13
PsiBlast_PDB
47.37
35%
-6
- C7 -
-
3NEL
1
SYD_THEKO
A:
[3-293]
---
R
T
H
Y
S
S
E
I
T
E
E
L
N
G
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
G
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
K
K
V
D
P
E
L
F
K
L
I
P
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
------
F
T
P
K
A
K
L
G
-
F
E
I
L
P
E
K
I
V
V
L
N
R
A
E
T
P
L
P
L
D
P
T
------
G
--
K
----
V
K
A
E
L
D
T
R
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
-
L
F
P
M
K
Y
F
E
E
D
A
F
-
L
A
Q
S
P
Q
L
Y
K
Q
I
M
M
A
S
G
L
D
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
E
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
E
H
N
A
K
E
L
D
I
L
N
F
E
L
E
E
P
K
L
P
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------