@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZ32: (2018-01-12 )
MAHIHFDYSKVAPFVNEQELGYMQSQVTAAHNELREGTGAGSDFRGWIDLPTNYDKEEFARIKEAAKKIQSDSEVLVVIGIGGSYLGARAAIDFLNHTFFNLLDSNTRKAPQIFFAGNSISSTYIADLIEVIGDRDFSVNVISKSGTTTEPAIAFRVFKELLVKKYGQEEANKRIYATTDKAKGAVKVEADAEGWETFVIPDDIGGRFSVLTAVGLLPIAVSGADIDALMQGAADASKAYSSDKLEENEAYQYAAMRNILYRKGKVTELLINYEPGMQYFSEWWKQLYGESEGKDQKGIYPSSANFSTDLHSLGQFIQEGRRNIFETVVKVEKPRKSITIPEQAEDLDGLGYLQGKEVDFVNTKAFEGTLLAHTDGDVPNLLVKIPEMDAYTLGYTMYFFEIAVGISGYLNGINPFDQPGVEAYKKNMFALLGKPGFEDLAKELNERL
Atome Classification :
(20 SA)
.........10----.........20....-----....30........40...----...-----..50----.------------....-...60........70--------.---------........80........90........100......-.110.......120.......130.......140.......150.......160.......-170.......180.......190....---...200.......210....-...220...-....230.......240.......250.......260-.--......270.......280.......290..----------.----------..--------..300.......310.......320..---.....330..-.--------...-------------------.340--..-.....350.......360..----..-----...370--------...--.....380.......390.......400.......410.......420.......430.......440......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
H
I
H
F
D
Y
S
K
-----VAPFV
N
E
Q
E
L
G
Y
M
Q
S
-----
Q
V
T
A
A
H
N
E
L
R
EGTGAGSD
F
----
R
G
W
-----IDLP----T------------NY
D
K
-
E
E
F
A
R
I
K
E
A
A
K
K
IQ---------S---------DS
E
V
L
V
V
I
GIGG
S
Y
L
G
A
R
A
A
I
D
F
L
N
H
T
F
F
N
L
LDSNTR-KA
P
Q
I
F
F
AGNSI
S
S
T
Y
I
A
D
L
I
E
V
IGDRD
F
S
V
N
V
I
SKSGTTTE
P
A
I
A
F
R
V
F
K
E
L
L
V
K
KY
G
Q
E
-
E
AN
K
R
I
Y
A
TTDKAK
G
A
V
K
V
E
ADAEG
W
E
---
T
F
V
IPDDIGG
R
F
S
V
L
T
AVG
L
-
L
P
I
AVSGA
D
-
I
D
A
L
M
QGAA
D
A
S
KAYSSDKLEEN
E
A
Y
Q
Y
A
A
M
R
N
I
L
YR-K--G
K
V
T
E
L
L
I
NYE
P
G
M
Q
Y
F
S
E
W
W
K
Q
L
YGESEGK----------D----------QK--------GIYPSSANF
S
T
D
L
H
S
L
G
Q
F
I
Q
E
G
R
R
N
I
---
F
E
T
V
V
K
VEKP-R--------KSI-------------------TIPE--QA-EDLDGLGYLQGKE
V
D
F
V
NTK----AF-----
E
G
T
L
L
---------AHT--DGDVP
N
L
L
V
KIPEMD
A
Y
T
LG
Y
T
M
Y
F
F
E
I
A
VG
I
S
G
Y
LNGINPFDQP
G
V
E
A
Y
K
K
N
M
F
A
L
LGKP
G
F
E
D
L
A
K
E
L
N
ERL
1
PsiBlast_PDB
90.43
66%
-93
- C5 -
-
3IFS
-
G6PI_BACAN
A:
[7-452]
--
H
V
T
F
D
Y
S
K
-----
A
L
S
F
I
G
E
H
E
I
T
Y
L
R
D
-----
A
V
K
V
T
H
H
A
I
H
E
K
T
G
A
G
N
D
F
----
L
G
W
-----
V
D
L
P
----
L
------------
Q
Y
D
K
-
E
E
F
A
R
I
Q
K
C
A
E
K
I
K
---------
N
---------
D
S
D
I
L
L
V
V
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
M
L
N
H
S
F
Y
N
T
L
S
K
E
Q
R
-
K
T
P
Q
V
L
F
V
G
Q
N
I
S
S
T
Y
M
K
D
L
M
D
V
L
E
G
K
D
F
S
I
N
V
I
S
K
S
G
T
T
T
E
P
A
L
A
F
R
I
F
R
K
L
L
E
E
K
Y
G
K
E
-
E
A
R
K
R
I
Y
A
T
T
D
K
A
R
G
A
L
K
T
L
A
D
N
E
G
Y
E
---
T
F
V
I
P
D
D
V
G
G
R
F
S
V
L
T
P
V
G
L
-
L
P
I
A
V
S
G
L
N
-
I
E
E
M
M
K
G
A
A
A
G
R
D
D
F
G
T
S
E
L
E
E
N
P
A
Y
Q
Y
A
V
V
R
N
A
L
Y
N
-
K
--
G
K
T
I
E
M
L
I
N
Y
E
P
A
L
Q
Y
F
A
E
W
W
K
Q
L
F
G
E
S
E
G
K
----------
D
----------
Q
K
--------
G
I
F
P
S
S
A
N
F
S
T
D
L
H
S
L
G
Q
Y
V
Q
E
G
R
R
D
L
---
F
E
T
V
L
K
V
G
K
S
-
T
--------
H
E
L
-------------------
T
I
E
S
--
E
E
-
N
D
L
D
G
L
N
Y
L
A
G
E
T
V
D
F
V
N
T
K
----
A
Y
-----
E
G
T
L
L
---------
A
H
S
--
D
G
G
V
P
N
L
I
V
N
I
P
E
L
N
E
Y
T
F
G
Y
L
V
Y
F
F
E
K
A
C
A
M
S
G
Y
L
L
G
V
N
P
F
D
Q
P
G
V
E
A
Y
K
K
N
M
F
A
L
L
G
K
P
G
F
E
E
L
K
A
E
L
E
E
R
L
2
PsiBlast_PDB
89.06
65%
-89
- C5 -
-
3FF1
1
G6PI_STAAC
A:
[5-446]
-
T
H
I
Q
L
D
F
S
K
-----
T
L
E
F
F
G
E
H
E
L
K
Q
Q
Q
E
-----
I
V
K
S
I
H
K
T
I
H
E
G
T
G
A
G
S
D
F
----
L
G
W
-----
V
D
L
P
----
V
------------
D
Y
D
K
-
E
E
F
S
R
I
V
E
A
S
K
R
I
K
---------
E
---------
N
S
D
V
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
M
L
T
S
S
F
-----
R
N
S
N
-
E
Y
P
E
I
V
F
V
G
N
H
L
S
S
T
Y
T
K
E
L
V
D
Y
L
A
D
K
D
F
S
V
N
V
I
S
K
S
G
T
T
T
E
P
A
V
A
F
R
L
F
K
Q
L
V
E
E
R
Y
G
K
E
-
E
A
Q
K
R
I
F
A
T
T
D
K
E
K
G
A
L
K
Q
L
A
T
N
E
G
Y
E
---
T
F
I
V
P
D
D
V
G
G
R
Y
S
V
L
T
A
V
G
L
-
L
P
I
A
T
A
G
I
N
-
I
E
A
M
M
I
G
A
A
K
A
R
E
E
L
S
S
D
K
L
E
E
N
I
A
Y
Q
Y
A
T
I
R
N
I
L
Y
A
-
K
--
G
Y
T
T
E
M
L
I
N
Y
E
P
S
M
Q
Y
F
N
E
W
W
K
Q
L
F
G
E
S
E
G
K
----------
D
----------
F
K
--------
G
I
Y
P
S
S
A
N
Y
T
T
D
L
H
S
L
G
Q
Y
V
Q
E
G
R
R
F
L
---
F
E
T
V
V
K
V
N
H
P
-
K
--------
Y
D
I
-------------------
T
I
E
K
--
D
S
-
D
D
L
D
G
L
N
Y
L
A
G
K
T
I
D
E
V
N
T
K
----
A
F
-----
E
G
T
L
L
---------
A
H
T
--
D
G
G
V
P
N
M
V
V
N
I
P
Q
L
D
E
E
T
F
G
Y
V
V
Y
F
F
E
L
A
C
A
M
S
G
Y
Q
L
G
V
N
P
F
N
Q
P
G
V
E
A
Y
K
Q
N
M
F
A
L
L
G
K
P
G
F
E
D
L
K
K
E
L
E
E
R
L
23
HHSearch
88.69
67%
-88
- C5 -
-
3FF1
1
G6PI_STAAC
B:
[4-445]
M
T
H
I
Q
L
D
F
S
K
-----
T
L
E
F
F
G
E
H
E
L
K
Q
Q
Q
E
-----
I
V
K
S
I
H
K
T
I
H
E
G
T
G
A
G
S
D
F
----
L
G
W
-----
V
D
L
P
----
V
------------
D
Y
D
K
-
E
E
F
S
R
I
V
E
A
S
K
R
I
K
---------
E
---------
N
S
D
V
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
M
L
T
S
S
F
R
N
S
-----
N
-
E
Y
P
E
I
V
F
V
G
N
H
L
S
S
T
Y
T
K
E
L
V
D
Y
L
A
D
K
D
F
S
V
N
V
I
S
K
S
G
T
T
T
E
P
A
V
A
F
R
L
F
K
Q
L
V
E
E
R
Y
G
K
E
-
E
A
Q
K
R
I
F
A
T
T
D
K
E
K
G
A
L
K
Q
L
A
T
N
E
G
Y
E
---
T
F
I
V
P
D
D
V
G
G
R
Y
S
V
L
T
A
V
G
L
-
L
P
I
A
T
A
G
I
N
-
I
E
A
M
M
I
G
A
A
K
A
R
E
E
L
S
S
D
K
L
E
E
N
I
A
Y
Q
Y
A
T
I
R
N
I
L
Y
A
-
K
--
G
Y
T
T
E
M
L
I
N
Y
E
P
S
M
Q
Y
F
N
E
W
W
K
Q
L
F
G
E
S
E
G
K
----------
D
----------
F
K
--------
G
I
Y
P
S
S
A
N
Y
T
T
D
L
H
S
L
G
Q
Y
V
Q
E
G
R
R
F
L
---
F
E
T
V
V
K
V
N
H
P
-
K
--------
Y
D
I
-------------------
T
I
E
K
--
D
S
-
D
D
L
D
G
L
N
Y
L
A
G
K
T
I
D
E
V
N
T
K
----
A
F
-----
E
G
T
L
L
---------
A
H
T
--
D
G
G
V
P
N
M
V
V
N
I
P
Q
L
D
E
E
T
F
G
Y
V
V
Y
F
F
E
L
A
C
A
M
S
G
Y
Q
L
G
V
N
P
F
N
Q
P
G
V
E
A
Y
K
Q
N
M
F
A
L
L
G
K
P
G
F
E
D
L
K
K
E
L
E
E
R
-
4
PsiBlast_PDB
88.28
64%
-91
- C5 -
-
1C7Q
1
G6PIB_GEOSE
A:
[3-443]
---
I
S
F
D
Y
S
N
-----
A
L
P
F
M
Q
E
N
E
L
D
Y
L
S
E
-----
F
V
K
A
A
H
H
M
L
H
E
R
K
G
P
G
S
D
F
----
L
G
W
-----
V
D
W
P
----
I
------------
R
Y
D
K
-
N
E
F
S
R
I
K
Q
A
A
E
R
I
R
---------
N
---------
H
S
D
A
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
A
L
S
H
T
F
H
N
Q
M
N
D
T
T
-----
Q
I
Y
F
A
G
Q
N
I
S
S
T
Y
I
S
H
L
L
D
V
L
E
G
K
D
L
S
I
N
V
I
S
K
S
G
T
T
T
E
P
A
I
A
F
R
I
F
R
D
Y
M
E
K
K
Y
G
K
E
-
E
A
R
K
R
I
Y
V
T
T
D
R
T
K
G
A
L
K
K
L
A
D
Q
E
G
Y
E
---
T
F
V
I
P
D
N
I
G
G
R
Y
S
V
L
T
A
V
G
L
-
L
P
I
A
V
A
G
L
N
-
I
D
R
M
M
E
G
A
A
S
A
Y
H
K
Y
N
N
P
D
L
L
T
N
E
S
Y
Q
Y
A
A
V
R
N
I
L
Y
R
-
K
--
G
K
A
I
E
L
L
V
N
Y
E
P
S
L
H
Y
V
S
E
W
W
K
Q
L
F
G
E
S
E
G
K
----------
D
----------
Q
K
--------
G
L
F
P
A
S
V
D
F
T
T
D
L
H
S
M
G
Q
Y
V
Q
E
G
R
R
N
L
---
I
E
T
V
L
H
V
K
K
P
-
Q
--------
I
E
L
-------------------
T
I
Q
E
--
D
P
-
E
N
I
D
G
L
N
F
L
A
G
K
T
L
D
E
V
N
K
K
----
A
F
-----
Q
G
T
L
L
---------
A
H
V
--
D
G
G
V
P
N
L
I
V
E
L
D
E
M
N
E
Y
T
F
G
E
M
V
Y
F
F
E
K
A
C
G
I
S
G
H
L
L
G
V
N
P
F
D
Q
P
G
V
E
A
Y
K
K
N
M
F
A
L
L
G
K
P
G
F
E
D
E
K
A
A
L
M
K
R
L
6
PsiBlast_PDB
87.89
64%
-92
- C5 -
-
2PGI
-
G6PIB_GEOSE
A:
[3-443]
---
I
S
F
D
Y
S
N
-----
A
L
P
F
M
Q
E
N
E
L
D
Y
L
S
E
-----
F
V
K
A
A
H
H
M
L
H
E
R
K
G
P
G
S
D
F
----
L
G
W
-----
V
D
W
P
----
I
------------
R
Y
D
K
-
N
E
F
S
R
I
K
Q
A
A
E
R
I
R
---------
N
---------
H
S
D
A
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
A
L
S
H
T
F
H
N
Q
M
N
D
T
T
-----
Q
I
Y
F
A
G
Q
N
I
S
S
T
Y
I
S
H
L
L
D
V
L
E
G
K
D
L
S
I
N
V
I
S
K
S
G
T
T
T
E
P
A
I
A
F
R
I
F
R
D
Y
M
E
K
K
Y
G
K
E
-
E
A
R
K
R
I
Y
V
T
T
D
R
T
K
G
A
L
K
K
L
A
D
Q
E
G
Y
E
---
T
F
V
I
P
D
N
I
G
G
R
Y
S
V
L
T
A
V
G
L
-
L
P
I
A
V
A
G
L
N
-
I
D
R
M
M
E
G
A
A
S
A
Y
H
K
Y
N
N
P
D
L
L
T
N
E
S
Y
Q
Y
A
A
V
R
N
I
L
Y
R
-
K
--
G
K
A
I
E
L
L
V
N
Y
E
P
S
L
H
Y
V
S
E
W
W
K
Q
L
F
G
E
S
E
G
K
----------
D
----------
Q
K
--------
G
L
F
P
A
S
V
D
F
T
T
D
L
H
S
M
G
Q
Y
V
Q
E
G
R
R
N
L
---
I
E
T
V
L
H
V
K
K
P
-
Q
--------
I
E
L
-------------------
T
I
Q
E
--
D
P
-
E
N
I
D
G
L
N
F
L
A
G
K
T
L
D
E
V
N
K
K
----
A
F
-----
Q
G
T
L
L
---------
A
H
V
--
D
G
G
V
P
N
L
I
V
E
L
D
E
M
N
E
Y
T
F
G
E
M
V
Y
F
F
E
K
A
C
G
I
S
G
H
L
L
G
V
N
P
F
D
Q
P
G
V
E
A
Y
K
K
N
M
F
A
L
L
G
K
P
G
F
E
D
E
K
A
A
L
M
K
R
L
3
PsiBlast_PDB
87.89
64%
-92
- C5 -
-
1B0Z
-
G6PIB_GEOSE
A:
[3-443]
---
I
S
F
D
Y
S
N
-----
A
L
P
F
M
Q
E
N
E
L
D
Y
L
S
E
-----
F
V
K
A
A
H
H
M
L
H
E
R
K
G
P
G
S
D
F
----
L
G
W
-----
V
D
W
P
----
I
------------
R
Y
D
K
-
N
E
F
S
R
I
K
Q
A
A
E
R
I
R
---------
N
---------
H
S
D
A
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
A
L
S
H
T
F
H
N
Q
M
N
D
T
T
-----
Q
I
Y
F
A
G
Q
N
I
S
S
T
Y
I
S
H
L
L
D
V
L
E
G
K
D
L
S
I
N
V
I
S
K
S
G
T
T
T
E
P
A
I
A
F
R
I
F
R
D
Y
M
E
K
K
Y
G
K
E
-
E
A
R
K
R
I
Y
V
T
T
D
R
T
K
G
A
L
K
K
L
A
D
Q
E
G
Y
E
---
T
F
V
I
P
D
N
I
G
G
R
Y
S
V
L
T
A
V
G
L
-
L
P
I
A
V
A
G
L
N
-
I
D
R
M
M
E
G
A
A
S
A
Y
H
K
Y
N
N
P
D
L
L
T
N
E
S
Y
Q
Y
A
A
V
R
N
I
L
Y
R
-
K
--
G
K
A
I
E
L
L
V
N
Y
E
P
S
L
H
Y
V
S
E
W
W
K
Q
L
F
G
E
S
E
G
K
----------
D
----------
Q
K
--------
G
L
F
P
A
S
V
D
F
T
T
D
L
H
S
M
G
Q
Y
V
Q
E
G
R
R
N
L
---
I
E
T
V
L
H
V
K
K
P
-
Q
--------
I
E
L
-------------------
T
I
Q
E
--
D
P
-
E
N
I
D
G
L
N
F
L
A
G
K
T
L
D
E
V
N
K
K
----
A
F
-----
Q
G
T
L
L
---------
A
H
V
--
D
G
G
V
P
N
L
I
V
E
L
D
E
M
N
E
Y
T
F
G
E
M
V
Y
F
F
E
K
A
C
G
I
S
G
H
L
L
G
V
N
P
F
D
Q
P
G
V
E
A
Y
K
K
N
M
F
A
L
L
G
K
P
G
F
E
D
E
K
A
A
L
M
K
R
L
5
PsiBlast_PDB
87.55
64%
-98
- C5 -
-
1C7R
1
G6PIB_GEOSE
A:
[3-443]
---
I
S
F
D
Y
S
N
-----
A
L
P
F
M
Q
E
N
E
L
D
Y
L
S
E
-----
F
V
K
A
A
H
H
M
L
H
E
R
K
G
P
G
S
D
F
----
L
G
W
-----
V
D
W
P
----
I
------------
R
Y
D
K
-
N
E
F
S
R
I
K
Q
A
A
E
R
I
R
---------
N
---------
H
S
D
A
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
A
L
S
----------
T
-----
Q
I
Y
F
A
G
Q
N
I
S
S
T
Y
I
S
H
L
L
D
V
L
E
G
K
D
L
S
I
N
V
I
S
K
S
G
T
T
T
E
P
A
I
A
F
R
I
F
R
D
Y
M
E
K
K
Y
G
K
E
-
E
A
R
K
R
I
Y
V
T
T
D
R
T
K
G
A
L
K
K
L
A
D
Q
E
G
Y
E
---
T
F
V
I
P
D
N
I
G
G
R
Y
S
V
L
T
A
V
G
L
-
L
P
I
A
V
A
G
L
N
-
I
D
R
M
M
E
G
A
A
S
A
Y
H
K
Y
N
N
P
D
L
L
T
N
E
S
Y
Q
Y
A
A
V
R
N
I
L
Y
R
-
K
--
G
K
A
I
E
L
L
V
N
Y
E
P
S
L
H
Y
V
S
E
W
W
K
Q
L
F
G
E
S
E
G
K
----------
D
----------
Q
K
--------
G
L
F
P
A
S
V
D
F
T
T
D
L
H
S
M
G
Q
Y
V
Q
E
G
R
R
N
L
---
I
E
T
V
L
H
V
K
K
P
-
Q
--------
I
E
L
-------------------
T
I
Q
E
--
D
P
-
E
N
I
D
G
L
N
F
L
A
G
K
T
L
D
E
V
N
K
K
----
A
F
-----
Q
G
T
L
L
---------
A
H
V
--
D
G
G
V
P
N
L
I
V
E
L
D
E
M
N
E
Y
T
F
G
E
M
V
Y
F
F
E
K
A
C
G
I
S
G
H
L
L
G
V
N
P
F
D
Q
P
G
V
E
A
Y
K
K
N
M
F
A
L
L
G
K
P
G
F
E
D
E
K
A
A
L
M
K
R
L
32
HHSearch
65.55
30%
-61
- C5 -
-
1ZZG
-
G6PI_THET8
A:
[1-415]
--
M
L
R
L
D
T
R
F
-----
L
P
G
-
F
-
P
E
A
L
S
R
H
G
P
-----
L
L
E
E
A
R
R
R
L
L
A
K
R
G
E
P
G
S
M
----
L
G
W
-----
M
D
L
P
----
E
--------------
D
T
-
E
T
L
R
E
V
R
R
Y
R
E
-
A
N
---------
P
---------
W
V
E
D
F
V
L
I
G
I
G
G
S
A
L
G
P
K
A
L
E
A
A
F
N
E
S
------------
G
V
R
F
H
Y
L
-
D
H
V
E
P
E
P
I
L
R
L
L
R
T
L
D
P
R
K
T
L
V
N
A
V
S
K
S
G
S
T
A
E
T
L
A
G
L
A
V
F
L
K
W
L
K
A
H
L
G
E
D
-
W
-
R
R
H
L
V
V
T
T
D
P
K
E
G
P
L
R
A
F
A
E
R
E
G
L
K
---
A
F
A
I
P
K
E
V
G
G
R
F
S
A
L
S
P
V
G
L
-
L
P
L
A
F
A
G
A
D
-
L
D
A
L
L
M
G
A
R
K
A
N
E
T
A
L
-
A
P
L
E
E
S
L
P
L
K
T
A
L
L
L
H
-
L
H
--
R
--
H
L
P
V
H
V
F
M
V
Y
S
E
R
L
S
H
L
P
S
W
F
V
Q
L
H
D
E
S
L
G
K
----------
V
DRQG
Q
-----
R
V
--------
G
T
T
A
V
P
A
L
G
P
K
D
Q
H
A
Q
V
Q
L
F
R
E
G
P
L
D
K
---
L
L
A
L
V
I
P
E
A
P
-
L
--------
E
D
V
-------------------
E
I
P
E
---
V
-
E
G
L
E
A
A
S
Y
L
F
G
K
T
L
F
Q
L
L
K
A
----
E
A
-----
E
A
T
Y
E
---------
A
L
A
--
E
A
G
Q
R
V
Y
A
L
F
L
P
E
V
S
P
Y
A
V
G
W
L
M
Q
H
L
M
W
Q
T
A
F
L
G
E
L
W
E
V
N
A
F
D
Q
P
G
V
E
L
G
K
V
L
T
R
K
R
L
A
G
--------------
27
HHSearch
64.53
31%
-13
- C5 -
-
2Q8N
2
G6PI_THEMA
B:
[31-453]
-------------------
L
T
D
E
D
V
K
S
V
E
E
-----
K
V
T
S
A
V
R
N
F
V
E
N
T
P
D
----------
F
-----
A
K
--------------------
L
D
R
-
S
W
I
D
S
V
K
S
L
E
-
D
W
I
---------
I
---------
N
F
D
T
V
V
V
L
G
I
G
G
S
G
L
G
N
L
A
L
H
Y
S
L
R
P
L
N
W
N
E
M
T
R
E
E
R
N
G
Y
A
R
V
F
V
V
-
D
N
V
D
P
D
L
M
S
S
V
L
D
R
I
D
P
K
T
T
L
F
N
V
I
S
K
S
G
S
T
A
E
V
M
A
T
Y
S
I
A
R
G
I
L
E
A
Y
G
L
-
D
--
P
R
E
H
M
L
I
T
T
D
P
E
K
G
F
L
R
K
L
V
K
E
E
G
F
R
---
S
L
E
V
P
P
G
V
G
G
R
F
S
V
L
T
P
V
G
L
-
L
S
A
M
A
E
G
I
D
-
I
D
E
L
H
E
G
A
K
D
A
F
E
K
S
M
K
E
N
I
L
E
N
P
A
A
M
I
A
L
T
H
Y
L
Y
L
N
-
K
--
G
K
S
I
S
V
M
M
A
Y
S
N
R
M
I
Y
L
V
D
W
Y
R
Q
L
W
A
E
S
L
G
K
----------
R
YNLKGEEV--
F
T
--------
G
Q
T
P
V
K
A
L
G
A
T
D
Q
H
S
Q
I
Q
L
Y
N
E
G
P
N
D
K
---
V
I
T
F
L
R
V
E
N
F
-
D
--------
R
E
I
-------------------
V
I
P
----
E
-
T
G
R
A
E
L
S
Y
L
A
R
K
K
L
S
E
L
L
L
A
----
E
Q
-----
T
G
T
E
E
---------
A
L
R
--
E
N
N
R
P
N
M
R
V
T
F
D
G
L
T
P
Y
N
V
G
Q
F
F
A
Y
Y
E
A
A
T
A
F
M
G
Y
L
L
E
I
N
P
F
D
Q
P
G
V
E
L
G
K
K
I
T
F
A
L
M
G
R
E
G
Y
T
Y
E
I
K
E
R
----
7
PsiBlast_PDB
62.51
30%
32
- C5 -
-
2Q8N
2
G6PI_THEMA
A:
[15-457]
---
L
K
F
D
F
S
N
LFEPN
I
S
G
G
L
T
D
E
D
V
K
S
V
E
E
-----
K
V
T
S
A
V
R
N
F
V
E
N
T
---
P
D
F
AKLD
R
S
W
-----
I
D
--------------------------------
S
V
K
S
L
E
---------
D
W
I
I
------
N
F
D
T
V
V
V
L
G
I
G
G
S
G
L
G
N
L
A
L
H
Y
S
L
R
P
L
N
W
N
E
M
T
R
E
E
R
-
N
G
Y
A
R
V
F
V
V
D
N
V
D
P
D
L
M
S
S
V
L
D
R
I
D
P
K
T
T
L
F
N
V
I
S
K
S
G
S
T
A
E
V
M
A
T
Y
S
I
A
R
G
I
L
-
E
A
Y
G
L
D
--
P
R
E
H
M
L
I
T
T
D
P
E
K
G
F
L
R
K
L
V
K
E
E
G
F
R
---
S
L
E
V
P
P
G
V
G
G
R
F
S
V
L
T
P
V
G
L
-
L
S
A
M
A
E
G
I
D
-
I
D
E
L
H
E
G
A
K
D
A
F
E
K
S
M
K
E
N
I
L
E
N
P
A
A
M
I
A
L
T
H
Y
L
Y
L
N
-
K
--
G
K
S
I
S
V
M
M
A
Y
S
N
R
M
I
Y
L
V
D
W
Y
R
Q
L
W
A
E
S
L
G
K
----------
R
----------
Y
N
LKGEEVF
T
G
Q
T
P
V
K
A
L
G
A
T
D
Q
H
S
Q
I
Q
L
Y
N
E
G
P
N
D
K
---
V
I
T
F
L
R
V
E
N
F
-
D
--------
R
E
I
-------------------
V
I
P
E
TG
R
A
-
E
----
L
S
Y
L
A
R
K
K
L
S
E
L
L
L
A
----
E
Q
-----
T
G
T
E
E
---------
A
L
R
--
E
N
N
R
P
N
M
R
V
T
F
D
G
L
T
P
Y
N
V
G
Q
F
F
A
Y
Y
E
A
A
T
A
F
M
G
Y
L
L
E
I
N
P
F
D
Q
P
G
V
E
L
G
K
K
I
T
F
A
L
M
G
R
E
G
Y
T
Y
E
I
K
E
R
S
K
K
V
8
PsiBlast_PDB
58.43
30%
4
- C5 -
-
1ZZG
-
G6PI_THET8
A:
[26-406]
---------------------------------------
A
R
R
R
L
L
A
K
R
G
E
P
G
S
M
----
L
G
W
-----
M
D
L
P
----
E
------------
D
T
E
T
L
R
E
V
R
R
Y
R
E
A
N
P
W
V
E
---------
D
-------------
F
V
L
I
G
I
G
G
S
A
L
G
P
K
A
L
-----
E
A
A
F
N
--
E
S
G
V
R
------
F
H
Y
L
D
H
V
E
P
E
P
I
L
R
L
L
R
T
L
D
P
R
K
T
L
V
N
A
V
S
K
S
G
S
T
A
E
T
L
A
G
L
A
V
F
L
K
W
L
K
A
H
L
G
-
E
-
D
W
R
R
H
L
V
V
T
T
D
P
K
E
G
P
L
R
A
F
A
E
R
E
G
L
K
---
A
F
A
I
P
K
E
V
G
G
R
F
S
A
L
S
P
V
G
L
-
L
P
L
A
F
A
G
A
D
-
L
D
A
L
L
M
G
A
R
K
A
N
E
T
-
A
L
A
P
L
E
E
S
L
P
L
K
T
A
L
L
L
H
--
L
H
-
R
--
H
L
P
V
H
V
F
M
V
Y
S
E
R
L
S
H
L
P
S
W
F
V
Q
L
H
D
E
S
L
G
K
VDRQG-----
Q
----------
R
V
--------
G
T
T
A
V
P
A
L
G
P
K
D
Q
H
A
Q
V
Q
L
F
R
E
G
P
L
D
K
---
L
L
A
L
V
I
P
E
A
P
-
L
--------
E
D
V
-------------------
E
I
P
E
---
V
-
E
G
L
E
A
A
S
Y
L
F
G
K
T
L
F
Q
L
L
K
A
----
E
A
-----
E
A
T
Y
E
---------
A
L
A
--
E
A
G
Q
R
V
Y
A
L
F
L
P
E
V
S
P
Y
A
V
G
W
L
M
Q
H
L
M
W
Q
T
A
F
L
G
E
L
W
E
V
N
A
F
D
Q
P
G
V
E
L
G
K
-----------------------
19
PsiBlast_PDB
56.64
23%
-45
- C5 -
-
2CXT
4
G6PI_MOUSE
A:
[152-520]
---------------------------------------------------------------------------------------------------------------------------------
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
--------
A
L
K
P
Y
S
K
-
G
G
P
R
V
W
F
V
S
N
-
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
D
P
-
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
-
E
F
G
I
D
P
Q
N
---
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
L
S
I
A
L
H
V
G
F
D
H
-
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
-
A
P
V
L
L
A
L
L
G
I
W
Y
I
-
N
CY
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
YITKSGARVD
H
----------
Q
T
--------
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
--------
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
--
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
----
V
F
-----
E
G
-------------------
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
----------------------
15
PsiBlast_PDB
56.49
23%
-47
- C5 -
-
2CXP
4
G6PI_MOUSE
A:
[152-520]
---------------------------------------------------------------------------------------------------------------------------------
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
--------
A
L
K
P
Y
S
K
-
G
G
P
R
V
W
F
V
S
N
-
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
D
P
-
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
-
E
F
G
I
D
P
Q
N
---
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
L
S
I
A
L
H
V
G
F
D
H
-
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
-
A
P
V
L
L
A
L
L
G
I
W
Y
I
-
N
CY
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
YITKSGARVD
H
----------
Q
T
--------
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
--------
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
KG
K
L
P
E
--
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
----
V
F
-----
E
G
-------------------
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
----------------------
20
PsiBlast_PDB
55.98
23%
-46
- C5 -
-
2CXU
2
G6PI_MOUSE
A:
[152-520]
---------------------------------------------------------------------------------------------------------------------------------
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
--------
A
L
K
P
Y
S
K
-
G
G
P
R
V
W
F
V
S
N
-
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
D
P
-
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
-
E
F
G
I
D
P
Q
N
---
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
L
S
I
A
L
H
V
G
F
D
H
-
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
-
A
P
V
L
L
A
L
L
G
I
W
Y
I
-
N
CY
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
YITKSGARVD
H
----------
Q
T
--------
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
--------
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
--
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
----
V
F
-----
E
G
-------------------
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
----------------------
18
PsiBlast_PDB
55.85
23%
-45
- C5 -
-
2CXS
4
G6PI_MOUSE
A:
[152-520]
---------------------------------------------------------------------------------------------------------------------------------
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
--------
A
L
K
P
Y
S
K
-
G
G
P
R
V
W
F
V
S
N
-
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
D
P
-
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
-
E
F
G
I
D
P
Q
N
---
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
L
S
I
A
L
H
V
G
F
D
H
-
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
-
A
P
V
L
L
A
L
L
G
I
W
Y
I
-
N
CY
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
YITKSGARVD
H
----------
Q
T
--------
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
--------
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
KG
K
L
P
E
--
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
----
V
F
-----
E
G
-------------------
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
----------------------
35
HHSearch
55.54
22%
14
- C5 -
-
3HJB
1
G6PI_VIBCH
A:
[73-554]
--
D
I
L
V
D
Y
S
K
-----
N
L
--
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
T
D
L
Q
S
A
I
T
A
M
F
K
G
E
A
I
N
Q
T
E
----
D
R
A
V
L
H
T
A
L
R
N
R
----
S
NS
P
V
L
V
NGEDV
M
P
A
V
N
-
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
GEWKGFTG
K
---------
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
V
P
Y
K
----------
N
H
L
T
V
H
F
V
-
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
D
W
F
L
K
A
A
G
D
E
A
H
V
A
K
H
F
A
A
L
S
T
N
G
-
K
A
V
----
A
E
F
G
I
D
TDN
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
L
-
S
I
I
L
S
I
G
Y
D
N
F
V
E
L
L
A
G
A
H
E
M
D
Q
H
F
V
N
T
P
F
E
S
N
I
P
V
I
L
A
L
I
G
I
W
Y
N
N
F
H
--
G
A
E
S
E
A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
----------
Y
VDRNGNPVTY
Q
T
--------
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
---
P
C
D
F
I
A
P
A
V
S
H
N
LVGD
H
---
H
Q
K
-------------------
L
M
S
N
--
F
F
-
A
Q
T
E
A
L
--
A
F
G
K
S
A
Q
A
V
Q
A
E
L
E
K
A
G
K
S
A
A
E
I
A
A
L
V
P
---------
F
K
V
F-
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
D
S
A
A
--------
17
PsiBlast_PDB
55.39
23%
-45
- C5 -
-
2CXR
4
G6PI_MOUSE
A:
[152-520]
---------------------------------------------------------------------------------------------------------------------------------
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
--------
A
L
K
P
Y
S
K
-
G
G
P
R
V
W
F
V
S
N
-
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
D
P
-
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
-
E
F
G
I
D
P
Q
N
---
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
L
S
I
A
L
H
V
G
F
D
H
-
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
-
A
P
V
L
L
A
L
L
G
I
W
Y
I
-
N
CY
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
YITKSGARVD
H
----------
Q
T
--------
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
--------
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
--
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
----
V
F
-----
E
G
-------------------
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
----------------------
13
PsiBlast_PDB
55.32
23%
-45
- C5 -
-
2CXN
2
G6PI_MOUSE
A:
[152-520]
---------------------------------------------------------------------------------------------------------------------------------
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
--------
A
L
K
P
Y
S
K
-
G
G
P
R
V
W
F
V
S
N
-
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
D
P
-
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
-
E
F
G
I
D
P
Q
N
---
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
L
S
I
A
L
H
V
G
F
D
H
-
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
-
A
P
V
L
L
A
L
L
G
I
W
Y
I
-
N
CY
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
YITKSGARVD
H
----------
Q
T
--------
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
--------
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
--
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
----
V
F
-----
E
G
-------------------
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
----------------------
16
PsiBlast_PDB
55.27
23%
-45
- C5 -
-
2CXQ
4
G6PI_MOUSE
A:
[152-520]
---------------------------------------------------------------------------------------------------------------------------------
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
--------
A
L
K
P
Y
S
K
-
G
G
P
R
V
W
F
V
S
N
-
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
D
P
-
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
-
E
F
G
I
D
P
Q
N
---
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
L
S
I
A
L
H
V
G
F
D
H
-
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
-
A
P
V
L
L
A
L
L
G
I
W
Y
I
-
N
CY
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
YITKSGARVD
H
----------
Q
T
--------
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
--------
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
KG
K
L
P
E
--
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
----
V
F
-----
E
G
-------------------
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
----------------------
25
HHSearch
55.26
23%
21
- C5 -
-
2CXT
4
G6PI_MOUSE
A:
[50-534]
--
H
I
L
V
D
Y
S
K
-----
N
L
--
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
----
D
R
A
V
L
H
V
A
L
R
N
R
SNT
P
I
K
V
DGKDV
M
----
P
E
V
N
-
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
---------
S
GDWKGYTGK
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
---------
G
G
P
R
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
-
T
A
K
V
K
E
F
G
I
D
-
P
Q
N
---
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
--
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
----------
Y
ITKSGARVDH
Q
T
--------
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
---
P
C
D
F
L
I
P
V
Q
T
-
Q
HPIRKG
L
H
H
K
I
-------------------
L
L
A
N
--
F
L
-
A
Q
T
E
--
A
L
M
K
G
K
-
L
P
E
E
A
R
K
----
E
L
-----
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
VF
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
A
--------