@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZA0: (2018-01-13 )
MDKPIHVFSEIGKLKTVLLKRPGQEVENLTPDIMDRLLFDDIPYLPIAQEEHDNFAKTLQNEGVETLYLEKLAAEAIDAGNVKEQFLNKMLDESHIASNAVREGLHEFLLSMETQEMVDKIMAGVRTKDIEVRSSSLYDLSADDDYPFYMDPMPNLYFTRDPSASMGNGMTVNKMTFEARRRESMFTEYILKHHPRFANKGIEVWLDRENPDHIEGGDELILSDKVVAVGISQRTNAKALEKLARHLFAKNSGFEKVLAIKIPNNRAMMHLDTVFTMVDHDKFTIHPAIQSKDGKMDVFTIEPDGDDIKITHSDNLHETMKAALGLDDLVLIPTGNGDEIVAPREQWNDGSNTLAIAPGVVVTYNRNYVSNELLRSYGIKVLEINSSELSRGRGGPRCMSQPLVREDLK
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70.......--.80-.--........90...-.-..-.-.100.......110..-.-.....120.......130...---.----....140....----...150.......160.......170.......180.......190.......200.....----.-.210.----......220.......230.......240.......-250........260.......270.......280.......290.......300..-----..---...310...-..---...320-........---------330.-....--.--.340.......350.......360.......370.......380.......390.......400.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDK
P
I
H
V
F
S
E
I
G
K
L
K
T
V
L
L
KRP
G
Q
E
V
E
NL
T
P
D
I
M
D
R
L
L
FDDIPYLPIAQ
E
E
H
D
N
F
A
K
T
L
Q
NEGV
E
T
L
Y
L
E
K
L
A
A
E
AID--AG--
N
--
V
K
E
Q
F
L
N
K
M
L
D
E
S
-
H
-
I
A
-
S
-
N
A
V
R
E
G
L
H
E
F
L
L
S
-
M
E
-
T
-
Q
E
M
V
D
K
I
M
AGVRT
K
D
I
-
E
V
RS---S----
S
L
Y
DLSADDDY----PFYMDPMP
N
L
Y
F
TRDPSASMGN
G
M
T
V
N
K
M
T
F
E
A
R
R
R
E
S
M
F
T
E
Y
I
L
K
HHP
R
F
ANKG
I
E
V
W
L
D----R-ENPDH----IEGG
D
E
L
I
LSD
K
V
V
A
V
GISQRT
N
A
K
A
L
E
K
L
A
R
H
L
F
A-KN-SGF
E
K
V
L
A
I
K
IPNN
R
A
M
M
H
L
D
T
V
F
T
MVDHD
K
F
T
I
HPAIQSKDG
K
M
D
V
F
T
IEPD-----G
D
---
D
I
K
I
T-HSD-
N
L
---
H
E
T
M
K
--
A
ALGLD
D
L
---------
V
L
I
P-TGNG--D--EIVAP
R
E
QWNDGS
N
T
L
A
IAP
G
V
V
V
T
YNR
N
Y
V
S
N
E
L
L
R
S
YG
I
K
V
L
E
IN
S
S
E
L
SRGRGGPRCMSQ
P
L
V
R
EDLK
1
PsiBlast_PDB
86.47
51%
3
- C5 -
-
4BOF
1
ARCA_STRPY
A:
[6-411]
---
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
L
V
--
T
P
--
E
--
I
R
E
A
F
I
D
E
Y
L
S
E
A
-
N
-
I
R
-
G
-
R
A
T
K
K
A
I
R
E
L
L
M
A
-
I
E
D
N
-
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
E
I
P
A
---
S
EK--
G
L
T
D
L
-
V
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
D
----
R
-
N
E
T
T
R
----
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
-
Q
N
-
L
G
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
E
---
G
D
L
R
V
Y
S
V
T
Y
D
-----
N
E
---
E
L
H
I
V
-
E
E
K
G
D
L
---
A
E
L
L
A
--
A
N
L
G
V
E
K
V
---------
D
L
I
R
-
C
G
G
D
--
N
--
L
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
14
PsiBlast_CBE
85.37
51%
6
- C5 -
-
4BOF
2
ARCA_STRPY
F:
[6-411]
---
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
L
V
--
T
P
--
E
--
I
R
E
A
F
I
D
E
Y
L
S
E
A
-
N
-
I
R
-
G
-
R
A
T
K
K
A
I
R
E
L
L
M
A
-
I
E
D
N
-
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
E
I
P
A
---
S
EK--
G
L
T
D
L
-
V
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
D
----
R
-
N
E
T
T
R
----
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
-
Q
N
-
L
G
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
E
---
G
D
L
R
V
Y
S
V
T
Y
D
-----
N
E
---
E
L
H
I
V
-
E
E
K
G
D
L
---
A
E
L
L
A
--
A
N
L
G
V
E
K
V
---------
D
L
I
R
-
C
G
G
D
--
N
--
L
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
13
PsiBlast_CBE
84.52
51%
8
- C5 -
-
4BOF
1
ARCA_STRPY
G:
[6-411]
---
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
L
V
--
T
P
--
E
--
I
R
E
A
F
I
D
E
Y
L
S
E
A
-
N
-
I
R
-
G
-
R
A
T
K
K
A
I
R
E
L
L
M
A
-
I
E
D
N
-
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
E
I
P
A
---
S
EK--
G
L
T
D
L
-
V
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
D
----
R
-
N
E
T
T
R
----
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
-
Q
N
-
L
G
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
E
---
G
D
L
R
V
Y
S
V
T
Y
D
-----
N
E
---
E
L
H
I
V
-
E
E
K
G
D
L
---
A
E
L
L
A
--
A
N
L
G
V
E
K
V
---------
D
L
I
R
-
C
G
G
D
--
N
--
L
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
35
HHSearch
84.39
52%
8
- C5 -
-
4BOF
-
ARCA_STRPY
H:
[5-411]
--
T
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
L
V
--
T
P
--
E
--
I
R
E
A
F
I
D
E
Y
L
S
E
A
-
N
-
I
R
-
G
-
R
A
T
K
K
A
I
R
E
L
L
M
A
I
E
D
-
N
-
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
-
P
E
I
P
ASE
K
----
G
L
T
D
L
V
-
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
D
----
R
-
N
E
T
T
R
----
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
-
Q
N
-
L
G
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
E
G
D
-
L
--
R
V
Y
S
V
T
Y
D
-----
N
E
---
E
L
H
I
V
E
E
K
G
-
D
L
---
A
E
L
L
A
--
A
N
L
G
V
E
K
V
---------
D
L
I
R
-
C
G
G
D
--
N
--
L
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
36
HHSearch
83.25
52%
9
- C5 -
-
4BOF
-
ARCA_STRPY
B:
[5-411]
--
T
P
I
H
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
L
V
--
T
P
--
E
--
I
R
E
A
F
I
D
E
Y
L
S
E
A
-
N
-
I
R
-
G
-
R
A
T
K
K
A
I
R
E
L
L
M
A
I
E
D
-
N
-
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
-
P
E
I
P
ASE
K
----
G
L
T
D
L
V
-
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
D
----
R
-
N
E
T
T
R
----
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
-
Q
N
-
L
G
F
K
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
E
I
E
G
D
-
L
--
R
V
Y
S
V
T
Y
D
-----
N
E
---
E
L
H
I
V
E
E
K
G
-
D
L
---
A
E
L
L
A
--
A
N
L
G
V
E
K
V
---------
D
L
I
R
-
C
G
G
D
--
N
--
L
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
-
8
PsiBlast_PDB
76.95
34%
-18
- C5 -
-
2AAF
-
ARCA_PSEAE
A:
[8-416]
----
L
G
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
I
Q
--
N
P
--
E
--
A
L
K
W
I
L
D
R
K
I
T
A
D
-
S
-
V
G
-
L
-
G
L
T
S
E
-
L
R
S
W
L
E
S
-
L
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
-
P
A
-
S
---
E
----
G
A
N
I
L
K
M
Y
R
E
Y
LGHS
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
----
D
-
P
D
K
D
H
GS
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
-
K
G
-
A
A
-
E
R
V
I
V
A
G
L
P
K
S
R
A
A
M
A
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
E
V
V
K
E
---
I
V
P
F
S
L
R
P
D
PSSPY
G
M
---
N
I
R
-
R
-
E
E
K
-
T
F
---
L
E
V
V
A
--
E
S
L
G
L
K
K
L
---------
R
V
V
E
-
T
G
------------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
-
M
T
C
P
I
V
R
D
P
I
-
9
PsiBlast_PDB
76.27
34%
-10
- C5 -
-
1RXX
-
ARCA_PSEAE
A:
[8-416]
----
L
G
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
I
Q
--
N
P
--
E
--
A
L
K
W
I
L
D
R
K
I
T
A
D
-
S
-
V
G
-
L
-
G
L
T
S
E
-
L
R
S
W
L
E
S
-
L
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
-
P
A
-
S
---
E
----
G
A
N
I
L
K
M
Y
R
E
Y
LGHS
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
----
D
-
P
D
K
D
H
GS
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
-
K
G
-
A
A
-
E
R
V
I
V
A
G
L
P
K
--
A
A
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
E
V
V
K
E
---
I
V
P
F
S
L
R
P
D
PSSPY
G
M
---
N
I
R
R
E
-
E
K
T
-
F
L
----
E
V
V
A
--
E
S
L
G
L
K
K
L
---------
R
V
V
E
-
T
G
-
G
--
N
--
S
F
--
E
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
C
M
T
C
P
I
V
R
D
P
I
-
31
PsiBlast_CBE
76.05
34%
-23
- C5 -
-
2A9G
1
ARCA_PSEAE
C:
[8-416]
----
L
G
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
I
Q
--
N
P
--
E
--
A
L
K
W
I
L
D
R
K
I
T
A
D
-
S
-
V
G
-
L
-
G
L
T
S
E
-
L
R
S
W
L
E
S
-
L
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
-
P
A
-
S
---
E
----
G
A
N
I
L
K
M
Y
R
E
Y
LGHS
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
----
D
-
P
D
K
D
H
GS
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
-
K
G
-
A
A
-
E
R
V
I
V
A
G
L
P
K
---
A
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
E
V
V
K
E
---
I
V
P
F
S
L
R
P
D
PSSPY
G
M
---
N
I
R
-
R
-
E
E
K
-
T
F
---
L
E
V
V
A
--
E
S
L
G
L
K
K
L
---------
R
V
V
E
-
T
G
------------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
A
M
T
C
P
I
V
R
D
P
I
-
3
PsiBlast_PDB
75.96
34%
-24
- C5 -
-
2ACI
-
ARCA_PSEAE
A:
[8-416]
----
L
G
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
I
Q
--
N
P
--
E
--
A
L
K
W
I
L
D
R
K
I
T
A
D
-
S
-
V
G
-
L
-
G
L
T
S
E
-
L
R
S
W
L
E
S
-
L
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
-
P
A
-
S
---
E
----
G
A
N
I
L
K
M
Y
R
E
Y
LGHS
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
A
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
----
D
-
P
D
K
D
H
GS
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
-
K
G
-
A
A
-
E
R
V
I
V
A
G
L
P
K
---
A
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
E
V
V
K
E
---
I
V
P
F
S
L
R
P
D
PSSPY
G
M
---
N
I
R
-
R
-
E
E
K
-
T
F
---
L
E
V
V
A
--
E
S
L
G
L
K
K
L
---------
R
V
V
E
-
T
G
------------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
C
M
T
C
P
I
V
R
D
P
I
-
32
PsiBlast_CBE
75.87
34%
-11
- C5 -
-
2A9G
1
ARCA_PSEAE
B:
[8-416]
----
L
G
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
I
Q
--
N
P
--
E
--
A
L
K
W
I
L
D
R
K
I
T
A
D
-
S
-
V
G
-
L
-
G
L
T
S
E
-
L
R
S
W
L
E
S
-
L
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
-
P
A
-
S
---
E
----
G
A
N
I
L
K
M
Y
R
E
Y
LGHS
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
----
D
-
P
D
K
D
H
GSST
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
-
K
G
-
A
A
-
E
R
V
I
V
A
G
L
P
K
S
R
--
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
E
V
V
K
E
---
I
V
P
F
S
L
R
P
D
PSSPY
G
M
---
N
I
R
-
R
-
E
E
K
-
T
F
---
L
E
V
V
A
--
E
S
L
G
L
K
K
L
---------
R
V
V
E
-
T
G
---------
A
A
E
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
A
M
T
C
P
I
V
R
D
P
I
-
4
PsiBlast_PDB
75.85
34%
-13
- C5 -
-
2A9G
1
ARCA_PSEAE
A:
[8-416]
----
L
G
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
I
Q
--
N
P
--
E
--
A
L
K
W
I
L
D
R
K
I
T
A
D
-
S
-
V
G
-
L
-
G
L
T
S
E
-
L
R
S
W
L
E
S
-
L
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
-
P
A
-
S
---
E
----
G
A
N
I
L
K
M
Y
R
E
Y
L
GHS
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
----
D
-
P
D
K
D
H
GS
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
-
K
G
-
A
A
-
E
R
V
I
V
A
G
L
P
K
S
R
A
A
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
E
V
V
K
E
---
I
V
P
F
S
L
R
P
D
PSSPY
G
M
---
N
I
R
-
R
-
E
E
K
-
T
F
---
L
E
V
V
A
--
E
S
L
G
L
K
K
L
---------
R
V
V
E
-
T
G
------------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
A
M
T
C
P
I
V
R
D
P
I
-
40
HHSearch
75.69
35%
-2
- C5 -
-
1LXY
3
ARCA_MYCAR
B:
[6-408]
K
F
K
G
I
H
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
Y
D
--
L
A
SQ
E
--
A
K
D
K
L
I
E
E
F
L
E
D
S
-
E
-
P
V
-
L
S
E
E
H
K
V
V
V
R
N
F
L
K
A
K
K
T
-
S
-
R
E
L
V
E
I
M
M
A
G
I
T
K
Y
D
L
-
G
I
E
A
-----------------
D
H
----
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
--
N
T
P
W
Y
Y
D
----
P
-
S
L
K
L
S
----
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
V
A
-
N
K
E
C
E
F
K
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
I
A
N
D
V
F
K
-
F
W
D
Y
D
L
V
N
G
-----
G
A
---
E
P
Q
P
V
E
N
G
L
-
P
L
---
E
G
L
L
Q
SI
I
N
K
K
P
V
------------
L
I
P
-
I
A
G
E
--
G
AS
Q
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K
7
PsiBlast_PDB
75.46
34%
-17
- C5 -
-
2ABR
-
ARCA_PSEAE
A:
[8-416]
----
L
G
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
I
Q
--
N
P
--
E
--
A
L
K
W
I
L
D
R
K
I
T
A
D
-
S
-
V
G
-
L
-
G
L
T
S
E
-
L
R
S
W
L
E
S
-
L
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
-
P
A
-
S
---
E
----
G
A
N
I
L
K
M
Y
R
E
Y
LGHS
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
----
D
-
P
D
K
D
H
GSST
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
-
K
G
-
A
A
-
E
R
V
I
V
A
G
L
P
K
S
---
M
H
L
A
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
E
V
V
K
E
---
I
V
P
F
S
L
R
P
D
PSSPY
G
M
---
N
I
R
-
R
-
E
E
K
-
T
F
---
L
E
V
V
A
--
E
S
L
G
L
K
K
L
---------
R
V
V
E
-
T
G
------------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
-
M
T
C
P
I
V
R
D
P
I
-
39
HHSearch
75.16
38%
-0
- C5 -
-
4E4J
-
?
B:
[35-432]
---
G
I
N
V
Y
S
E
I
G
E
L
K
E
V
L
V
H
T
P
G
D
E
I
R
Y
T
A
P
S
R
L
E
E
L
L
F
S
A
V
L
K
A
D
T
A
I
E
E
H
K
G
F
V
K
I
L
Q
N
N
G
I
K
V
I
Q
L
C
D
L
V
A
E
T
Y
E
--
L
C
SK
E
--
V
R
N
S
F
I
E
Q
Y
L
D
E
A
-
L
-
P
V
L
K
-
K
E
I
R
P
V
V
K
D
Y
L
L
S
-
F
P
-
T
-
V
Q
M
V
R
K
M
M
S
G
I
L
A
N
E
L
-
N
I
K
-----------------
Q
D
N
----
P
L
I
I
D
G
M
P
N
L
Y
F
T
R
D
P
F
A
S
M
G
N
G
V
S
I
N
C
M
K
Y
P
T
R
K
R
E
V
I
F
S
R
F
V
F
T
N
N
P
K
Y
K
--
N
T
P
R
Y
F
D
----
I
V
G
N
N
G
T
----
I
E
G
G
D
I
F
I
Y
N
S
K
T
L
V
I
G
N
S
E
R
T
N
F
A
A
I
E
S
V
A
K
N
I
Q
A
-
N
K
D
C
T
F
E
R
I
V
V
I
N
V
P
P
M
P
N
L
M
H
L
D
T
W
L
T
M
L
D
Y
D
K
F
L
Y
S
P
N
M
M
N
V
-
L
--
K
I
W
E
I
D
L
N
-----
V
K
---
P
V
K
F
V
E
K
K
G
-
T
L
---
E
E
V
L
Y
SI
I
D
K
K
P
I
------------
L
I
P
-
I
A
G
K
GA
N
--
Q
L
D
I
D
I
E
T
H
F
D
G
T
N
Y
L
T
I
A
P
G
V
V
V
G
Y
E
R
N
E
K
T
Q
K
A
L
V
E
A
G
I
K
V
L
S
F
N
G
S
Q
L
S
L
G
M
G
S
A
R
C
M
S
M
P
L
I
R
E
N
L
K
38
HHSearch
75.10
33%
-12
- C5 -
-
2AAF
-
ARCA_PSEAE
C:
[7-417]
---
K
L
G
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
I
Q
--
N
P
--
E
--
A
L
K
W
I
L
D
R
K
I
T
A
D
---
S
V
-
G
-
L
G
L
T
S
E
L
R
S
W
L
E
S
-
L
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
-
P
A
S
E
---
G
ANIL
K
M
Y
R
E
Y
-
L
G
H
S
----
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
DPDK
D
-
H
G
S
S
T
----
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
-
K
--
G
A
A
E
R
V
I
V
A
G
L
P
K
S
R
A
A
M
A
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
E
V
V
K
E
-
I
--
V
P
F
S
L
R
P
D
-----
P
S
SPY
G
M
N
I
R
R
E
E
K
-
T
F
---
L
E
V
V
A
--
E
S
L
G
L
K
------------
K
L
R
-
V
V
E
T
G--------
E
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
-
M
T
C
P
I
V
R
D
P
I
D
30
PsiBlast_CBE
74.88
34%
-8
- C5 -
-
2A9G
1
ARCA_PSEAE
D:
[8-416]
----
L
G
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
I
Q
--
N
P
--
E
--
A
L
K
W
I
L
D
R
K
I
T
A
D
-
S
-
V
G
-
L
-
G
L
T
S
E
-
L
R
S
W
L
E
S
-
L
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
-
P
A
-
S
---
E
----
G
A
N
I
L
K
M
Y
R
E
Y
LGHS
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
----
D
-
P
D
K
D
H
GSST
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
-
K
G
-
A
A
-
E
R
V
I
V
A
G
L
P
K
S
R
A
A
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
E
V
V
K
E
---
I
V
P
F
S
L
R
P
D
PSSPY
G
M
---
N
I
R
-
R
-
E
E
K
-
T
F
---
L
E
V
V
A
--
E
S
L
G
L
K
K
L
---------
R
V
V
E
-
T
G
-
G
----------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
A
M
T
C
P
I
V
R
D
P
I
-
6
PsiBlast_PDB
74.79
36%
13
- C5 -
-
1S9R
3
ARCA_MYCAR
A:
[9-409]
--
K
G
I
H
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
Y
D
--
L
A
--
S
Q
E
A
K
D
K
L
I
E
E
F
L
E
D
S
-
E
P
V
L
-
S
-
E
E
H
K
V
V
V
R
N
F
L
K
A
-
K
K
-
T
S
R
E
L
V
E
I
M
M
A
G
I
------------------
T
K
Y
D
L
G
I
E
A
D
H
----
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
N
T
--
P
W
Y
Y
D
----
P
-
S
L
K
L
S
----
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
V
A
N
K
E
-
C
E
F
K
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
I
A
N
------
D
V
F
K
F
W
------------
D
Y
D
L
V
-
N
G
G
-
A
E
---
P
Q
P
V
E
--
N
G
L
P
L
E
G
L
L
Q
S
I
IN
K
K
P
V
L
I
P
I
A
G
E
G
A-
S
--
Q
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K
5
PsiBlast_PDB
74.65
36%
15
- C5 -
-
1LXY
3
ARCA_MYCAR
A:
[8-408]
--
K
G
I
H
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
Y
D
--
L
A
--
S
Q
E
A
K
D
K
L
I
E
E
F
L
E
D
S
-
E
P
V
L
-
S
-
E
E
H
K
V
V
V
R
N
F
L
K
A
-
K
K
-
T
S
R
E
L
V
E
I
M
M
A
G
I
------------------
T
K
Y
D
L
G
I
E
A
D
H
----
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
N
T
--
P
W
Y
Y
D
----
P
-
S
L
K
L
S
----
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
V
A
N
K
E
-
C
E
F
K
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
I
A
N
------
D
V
F
K
F
W
------------
D
Y
D
L
V
-
N
G
G
-
A
E
---
P
Q
P
V
E
--
N
G
L
P
L
E
G
L
L
Q
S
I
IN
K
K
P
V
L
I
P
I
A
G
E
G
A-
S
--
Q
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K
2
PsiBlast_PDB
74.50
37%
5
- C5 -
-
4E4J
-
?
A:
[36-432]
----
I
N
V
Y
S
E
I
G
E
L
K
E
V
L
V
H
T
P
G
D
E
I
R
Y
T
A
P
S
R
L
E
E
L
L
F
S
A
V
L
K
A
D
T
A
I
E
E
H
K
G
F
V
K
I
L
Q
N
N
G
I
K
V
I
Q
L
C
D
L
V
A
E
T
Y
E
L
C
S
K
--
E
--
V
R
N
S
F
I
E
Q
Y
L
D
E
A
L
P
-
V
L
-
K
-
K
E
I
R
P
V
V
K
D
Y
L
L
S
-
F
P
-
T
-
V
Q
M
V
R
K
M
M
S
G
I
L
A
N
E
L
-
N
I
K
Q
-----------------
D
N
----
P
L
I
I
D
G
M
P
N
L
Y
F
T
R
D
P
F
A
S
M
G
N
G
V
S
I
N
C
M
K
Y
P
T
R
K
R
E
V
I
F
S
R
F
V
F
T
N
N
P
K
Y
K
N
T
--
P
R
Y
F
D
I---
V
-
G
N
N
G
T
----
I
E
G
G
D
I
F
I
Y
N
S
K
T
L
V
I
G
N
S
E
R
T
N
F
A
A
I
E
S
V
A
K
N
I
Q
A
N
K
D
-
C
T
F
E
R
I
V
V
I
N
V
P
P
M
P
N
L
M
H
L
D
T
W
L
T
M
L
D
Y
D
K
F
L
Y
S
P
N
M
M
N
V
---
L
K
I
W
E
I
D
L
N
-----
V
K
---
P
V
K
F
V
-
E
K
K
-
G
T
---
L
E
E
V
L
--
Y
S
I
I
D
K
K
P
---------
I
L
I
P
I
A
G
K
G
A-
N
--
Q
L
D
I
D
I
E
T
H
F
D
G
T
N
Y
L
T
I
A
P
G
V
V
V
G
Y
E
R
N
E
K
T
Q
K
A
L
V
E
A
G
I
K
V
L
S
F
N
G
S
Q
L
S
L
G
M
G
S
A
R
C
M
S
M
P
L
I
R
E
N
L
K
33
PsiBlast_CBE
74.32
36%
16
- C5 -
-
1LXY
3
ARCA_MYCAR
B:
[8-408]
--
K
G
I
H
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
Y
D
--
L
A
--
S
QE
A
K
D
K
L
I
E
E
F
L
E
D
S
-
E
P
V
L
-
S
-
E
E
H
K
V
V
V
R
N
F
L
K
A
-
K
K
-
T
S
R
E
L
V
E
I
M
M
A
G
I
------------------
T
K
Y
D
L
G
I
E
A
D
H
----
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
N
T
--
P
W
Y
Y
D
----
P
-
S
L
K
L
S
----
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
V
A
N
K
E
-
C
E
F
K
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
I
A
N
------
D
V
F
K
F
W
------------
D
Y
D
L
V
-
N
G
G
-
A
E
---
P
Q
P
V
E
--
N
G
L
P
L
E
G
L
LQSIINKKP
V
L
I
P
I
A
G
E
G
A-
S
--
Q
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K
34
PsiBlast_CBE
74.19
36%
15
- C5 -
-
1S9R
3
ARCA_MYCAR
B:
[9-409]
--
K
G
I
H
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
Y
D
--
L
A
--
S
QE
A
K
D
K
L
I
E
E
F
L
E
D
S
-
E
P
V
L
-
S
-
E
E
H
K
V
V
V
R
N
F
L
K
A
-
K
K
-
T
S
R
E
L
V
E
I
M
M
A
G
I
------------------
T
K
Y
D
L
G
I
E
A
D
H
----
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
N
T
--
P
W
Y
Y
D
----
P
-
S
L
K
L
S
----
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
V
A
N
K
E
-
C
E
F
K
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
I
A
N
------
D
V
F
K
F
W
------------
D
Y
D
L
V
-
N
G
G
-
A
E
---
P
Q
P
V
E
--
N
G
L
P
L
E
G
L
LQSIINKKP
V
L
I
P
I
A
G
E
G
A-
S
--
Q
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K
41
HHSearch
73.90
35%
3
- C5 -
-
1S9R
3
ARCA_MYCAR
A:
[7-409]
K
F
K
G
I
H
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
Y
D
--
L
A
S
Q
E
--
A
K
D
K
L
I
E
E
F
L
E
D
S
-
E
-
P
V
-
L
S
E
E
H
K
V
V
V
R
N
F
L
K
A
K
K
T
-
S
-
R
E
L
V
E
I
M
M
A
G
I
T
K
Y
D
L
-
G
I
E
A
-----------------
D
H
----
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
--
N
T
P
W
Y
Y
D
----
P
-
S
L
K
L
S
----
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
V
A
-
N
K
E
C
E
F
K
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
I
A
N
D
V
F
K
-
F
W
D
Y
D
L
V
N
G
-----
G
A
---
E
P
Q
P
V
E
N
G
L
-
P
L
E
G
L
L
Q
S
I
---
I
N
K
K
P
V
------------
L
I
P
-
I
A
G
E
GA
S
--
Q
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K