@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y0S5: (2018-01-22 )
MKTAFLFSGQGAQYQGMGKDLYEEAVVKQTFDEASEILGYDMAELCFTENERLDQTQYTQPAILTVSIAYYRLLKEHGIIPDAALGLSLGEYSALVASNALSFTEAVALVAKRGAYMTEAAPAGSGKMVAVMNAPIETIEESCHEASKYGIVSPANYNTPQQIVIGGEEKAVDEAVLLLKEKGFKRMIPLNVSGPFHTAILEPAAKKLAKDLSQIQFSEPSFPIISNTTTEIMKKETIAGLLEQQVMQPVRFYESIHKLKTIGIEQVIEVGPGKVLSGFMKKIDKTIPVLRVENKQTFDETIAIL
Atome Classification :
(23 SA)
.........10.....-...---20-..-.-...-..30........40.....-.-.-.50-.-...--.....60......-..70...-..-.-.-.80----....----....90........100.......110.......120.......130.......140.....-..150.......160.......170.......180.......-.190.......200.......210.......220......-.----230-.-..-.-....240.......250.......260.......270.......280.......290.......300...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
T
A
F
L
FSGQGAQYQG-M
G
K
---
D
L
-
Y
E
-
E
-
A
V
V
-
K
Q
T
F
D
E
A
S
E
I
L
G
Y
D
M
A
E
L
C-F-T-EN--E-RLD--QTQYTQ
P
A
I
L
T
V
S
-
I
A
Y
Y
R
L
L
-
K
E-H-G-IIP----
D
A
A
L----GLSL
G
E
Y
S
A
L
V
A
SN
A
L
S
F
T
E
A
V
A
L
V
A
KRGAYMTEAAPAGSG
K
M
V
A
V
MNA
P
I
E
T
I
E
E
S
C
H
E
A
S
-KYGIVSPANYNTP
Q
Q
I
V
IGGEEK
A
V
D
E
A
V
L
L
L
K
E-KGF
K
R
MI-PLNVSGP
F
H
T
A
I
L
E
P
A
A
K
K
L
A
K
D
L
S
Q
IQFSEPS
F
P
IISN
T
-
T
----
T
-
E
-
I
-
M
K
-
K
-
E
T
I
A
G
L
L
E
Q
Q
V
M
Q
P
V
R
F
Y
E
S
I
H
K
L
K
T
I
G
I
E
Q
V
I
EVG
P
G
K
V
L
S
G
F
M
K
K
I
D
KTI
P
V
L
R
VENKQ
T
F
D
E
T
IAIL
1
PsiBlast_PDB
83.90
62%
0
- C1 -
-
3IM8
-
?
A:
[3-300]
-
K
T
A
F
L
F
A
G
Q
G
A
Q
Y
L
G
-
M
G
R
---
D
F
-
Y
D
-
Q
Y
P
I
V
-
K
E
T
I
D
R
A
S
Q
V
L
G
Y
D
L
R
Y
L
I
-
D
-
T
-
E
E
--
D
-
K
L
N
--
Q
T
R
Y
T
Q
P
A
I
L
A
T
S
-
V
A
I
Y
R
L
L
-
Q
E
-
K
-
G
-
Y
Q
P
----
D
M
V
A
----
G
L
S
L
G
E
Y
S
A
L
V
A
S
G
A
L
D
F
E
D
A
V
A
L
V
A
K
R
G
A
Y
M
E
E
A
A
P
A
D
S
G
K
M
V
A
V
L
N
T
P
V
E
V
I
E
E
A
C
Q
K
A
S
-
E
L
G
V
V
T
P
A
N
Y
N
T
P
A
Q
I
V
I
A
G
E
V
V
A
V
D
R
A
V
E
L
L
Q
E
-
A
G
A
K
R
L
I
-
P
L
K
V
S
G
P
F
H
T
S
L
L
E
P
A
S
Q
K
L
A
E
T
L
A
Q
V
S
F
S
D
F
T
C
P
L
V
G
N
T
-
E
----
A
-
A
-
V
-
M
Q
-
K
-
E
D
I
A
Q
L
L
T
R
Q
V
K
E
P
V
R
F
Y
E
S
I
G
V
M
Q
E
A
G
I
S
N
F
I
E
I
G
P
G
K
V
L
S
G
F
V
K
K
I
D
Q
T
A
H
L
A
H
V
E
D
Q
A
S
L
-------
9
PsiBlast_PDB
74.69
42%
-24
- C1 -
-
2G2Y
-
FABD_ECOLI
A:
[4-291]
---
A
F
V
F
P
G
Q
G
S
Q
T
V
G
-
M
L
A
---
D
M
-
A
A
-
S
Y
P
I
V
-
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
-
Q
-
Q
G
P
A
--
E
-
E
L
N
--
K
T
W
Q
T
Q
P
A
L
L
T
A
S
-
V
A
L
Y
R
V
W
-
Q
Q
-
Q
-
G
G
K
A
P
----
A
M
M
A
----
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
K
A
C
E
E
A
A
-
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
-
D
----
V
-
K
-
C
E
T
N
-
G
-
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
------------------
43
HHSearch
74.66
40%
-12
* C1 *
-
2G1H
1
FABD_ECOLI
A:
[2-305]
-
Q
F
A
F
V
F
P
G
Q
G
S
Q
T
V
G
-
M
L
A
---
D
M
-
A
A
-
S
Y
P
I
V
-
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
-
Q
-
Q
G
P
A
--
E
-
E
L
N
--
K
T
W
Q
T
Q
P
A
L
L
T
A
S
-
V
A
L
Y
R
V
W
-
Q
Q
-
Q
G
G
-
K
A
P
----
A
M
M
A
----
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
K
A
C
E
E
A
A
-
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
-
D
----
V
-
K
C
E
-
T
N
-
G
-
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
----
8
PsiBlast_PDB
73.97
42%
-24
- C1 -
-
2G2O
-
FABD_ECOLI
A:
[4-291]
---
A
F
V
F
P
G
Q
G
S
Q
T
V
G
-
M
L
A
---
D
M
-
A
A
-
S
Y
P
I
V
-
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
-
Q
-
Q
G
P
A
--
E
-
E
L
N
--
K
T
W
Q
T
Q
P
A
L
L
T
A
S
-
V
A
L
Y
R
V
W
-
Q
Q
-
Q
-
G
G
K
A
P
----
A
M
M
A
----
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
K
A
C
E
E
A
A
-
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
-
D
----
V
-
K
-
C
E
T
N
-
G
-
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
------------------
7
PsiBlast_PDB
73.25
42%
-23
- C1 -
-
2G1H
1
FABD_ECOLI
A:
[4-291]
---
A
F
V
F
P
G
Q
G
S
Q
T
V
G
-
M
L
A
---
D
M
-
A
A
-
S
Y
P
I
V
-
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
-
Q
-
Q
G
P
A
--
E
-
E
L
N
--
K
T
W
Q
T
Q
P
A
L
L
T
A
S
-
V
A
L
Y
R
V
W
-
Q
Q
-
Q
-
G
G
K
A
P
----
A
M
M
A
----
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
K
A
C
E
E
A
A
-
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
-
D
----
V
-
K
-
C
E
T
N
-
G
-
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
------------------
10
PsiBlast_PDB
72.85
42%
-24
- C1 -
-
2G2Z
2
FABD_ECOLI
A:
[4-291]
---
A
F
V
F
P
G
Q
G
S
Q
T
V
G
-
M
L
A
---
D
M
-
A
A
-
S
Y
P
I
V
-
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
-
Q
-
Q
G
P
A
--
E
-
E
L
N
--
K
T
W
Q
T
Q
P
A
L
L
T
A
S
-
V
A
L
Y
R
V
W
-
Q
Q
-
Q
-
G
G
K
A
P
----
A
M
M
A
----
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
K
A
C
E
E
A
A
-
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
-
D
----
V
-
K
-
C
E
T
N
-
G
-
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
------------------
3
PsiBlast_PDB
72.50
43%
-16
- C1 -
-
3HJV
5
?
A:
[8-309]
-
K
F
A
I
V
F
P
G
Q
G
S
Q
A
V
G
-
M
L
A
---
D
L
-
A
E
-
Q
Y
A
V
V
-
K
Q
T
F
A
E
A
S
E
V
L
G
Y
D
L
W
A
L
V
-
Q
-
D
-
G
P
V
-
E
-
D
L
N
--
Q
T
F
R
T
Q
P
A
L
L
A
A
S
-
V
A
I
W
R
V
W
-
Q
Q
-
L
-
G
-
L
E
Q
----
P
A
V
L
A
---
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
K
Q
A
I
K
L
V
E
L
R
G
Q
L
M
Q
Q
A
V
P
A
G
T
G
A
M
Y
A
I
I
G
L
E
D
E
A
I
A
K
A
C
A
D
A
A
-
Q
G
E
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
Q
K
D
A
V
E
R
A
G
V
L
C
K
E
-
A
G
A
K
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
E
L
A
K
T
L
A
E
L
E
F
N
A
P
Q
I
P
V
I
N
N
V
-
D
VVAE
T
-
D
-
P
-
V
K
-----
I
K
D
A
L
I
R
Q
L
Y
S
P
V
R
W
T
E
C
V
E
Q
M
S
A
Q
G
V
E
K
L
I
E
-
G
P
G
K
V
L
T
G
L
T
K
R
I
V
K
T
L
E
G
V
A
V
N
D
V
A
S
L
D
------
11
PsiBlast_PDB
72.47
42%
-22
- C1 -
-
1MLA
-
FABD_ECOLI
A:
[5-292]
---
A
F
V
F
P
G
Q
G
S
Q
T
V
G
-
M
L
A
---
D
M
-
A
A
-
S
Y
P
I
V
-
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
-
Q
-
Q
G
P
A
--
E
-
E
L
N
--
K
T
W
Q
T
Q
P
A
L
L
T
A
S
-
V
A
L
Y
R
V
W
-
Q
Q
-
Q
-
G
G
K
A
P
----
A
M
M
A
----
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
K
A
C
E
E
A
A
-
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
-
D
----
V
-
K
-
C
E
T
N
-
G
-
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
------------------
13
PsiBlast_PDB
72.03
40%
-17
- C1 -
-
3TQE
3
?
A:
[9-299]
---
A
F
V
F
P
G
Q
G
S
Q
H
L
G
-
M
L
A
---
E
L
G
L
Q
-
Q
-
P
I
V
-
L
E
T
F
Q
Q
A
S
S
A
L
A
Y
D
L
W
A
L
V
Q
H
-
G
-
P
Q
--
E
-
R
L
D
--
Q
T
Q
F
T
Q
P
A
L
L
T
A
D
-
V
A
I
F
R
C
W
-
E
A
L
G
-
G
-
P
K
P
----
Q
V
M
A
----
G
H
S
L
G
E
Y
A
A
L
V
C
A
G
A
L
K
F
E
E
A
V
K
L
V
E
K
R
G
Q
Y
M
Q
E
A
V
P
V
G
E
G
A
M
G
A
I
I
G
L
N
E
A
E
I
E
S
I
C
E
N
A
A
-
L
G
Q
V
V
Q
P
A
N
L
N
S
T
D
Q
T
V
I
S
G
H
S
E
A
V
D
R
A
L
N
M
A
K
T
-
E
G
A
K
I
A
K
-
R
I
P
V
S
V
P
S
H
C
P
L
M
Q
P
A
A
D
R
L
A
Q
D
I
A
K
I
S
I
D
S
P
K
V
P
V
I
H
N
V
D
V
----
V
-
D
-
H
-
N
E
-
A
-
N
I
I
R
G
A
L
I
K
Q
L
V
R
P
V
R
W
V
E
T
I
K
Y
I
E
E
Q
G
I
K
V
F
M
E
C
G
P
D
N
K
L
A
G
L
I
K
R
I
D
R
Q
S
E
I
L
---------------
17
PsiBlast_PDB
70.70
34%
-69
- C1 -
-
4RR5
-
FABD_SYNY3
A:
[1-289]
M
K
T
A
W
V
F
P
G
Q
G
S
Q
A
V
G
-
M
G
V
---
D
L
-
L
S
-
T
-
A
I
A
-
K
E
K
Y
Q
Q
A
E
E
I
L
G
W
S
V
V
E
K
C
-
Q
-
G
-
D
E
--
A
-
S
L
A
--
L
T
Q
N
T
Q
P
C
L
Y
V
I
E
-
A
I
L
A
D
L
L
-
R
D
-
K
-
G
-
F
Q
P
----
D
Y
V
A
----
G
H
S
L
G
E
Y
S
A
L
Y
A
A
G
V
F
D
F
A
T
G
L
Q
L
V
K
Q
R
S
E
V
M
---
A
S
A
S
G
G
M
M
A
A
L
M
K
F
D
Q
T
Q
L
Q
Q
A
L
T
D
N
T
-
E
---
V
V
L
A
N
D
N
S
P
E
Q
V
V
I
S
G
T
V
A
G
V
E
A
I
L
A
N
V
K
A
----
R
R
A
V
-
P
L
K
V
S
G
A
F
H
S
S
F
M
A
Q
P
S
Q
S
F
A
Q
T
L
T
A
C
H
F
N
D
A
T
V
P
V
L
S
N
V
-
D
P---
S
-
P
-
T
-
Q
N
-
G
-
D
R
L
K
E
K
L
I
Q
Q
M
T
G
S
V
R
W
R
E
T
M
V
N
L
G
E
I
G
A
T
D
Y
W
E
V
G
P
G
K
V
L
T
G
L
C
K
---
R
T
C
P
D
L
N
L
K
N
I
G
Q
L
D
D
-----
46
HHSearch
70.22
34%
-73
- C1 -
-
4RR5
-
FABD_SYNY3
A:
[1-291]
M
K
T
A
W
V
F
P
G
Q
G
S
Q
A
V
G
-
M
G
V
---
D
L
-
L
S
-
T
-
A
I
A
-
K
E
K
Y
Q
Q
A
E
E
I
L
G
W
S
V
V
E
K
C
-
Q
-
G
-
D
E
--
A
-
S
L
A
--
L
T
Q
N
T
Q
P
C
L
Y
V
I
E
-
A
I
L
A
D
L
L
-
R
D
-
K
-
G
-
F
Q
P
----
D
Y
V
A
----
G
H
S
L
G
E
Y
S
A
L
Y
A
A
G
V
F
D
F
A
T
G
L
Q
L
V
K
Q
R
S
E
V
M
A
S
A
S
G
---
G
M
M
A
A
L
M
K
F
D
Q
T
Q
L
Q
Q
A
L
T
D
----
N
T
E
V
V
L
A
N
D
N
S
P
E
Q
V
V
I
S
G
T
V
A
G
V
E
A
I
L
A
N
V
K
A
-
R
---
R
A
V
-
P
L
K
V
S
G
A
F
H
S
S
F
M
A
Q
P
S
Q
S
F
A
Q
T
L
T
A
C
H
F
N
D
A
T
V
P
V
L
S
N
V
-
D
----
P
-
S
P
T
-
Q
N
-
G
-
D
R
L
K
E
K
L
I
Q
Q
M
T
G
S
V
R
W
R
E
T
M
V
N
L
G
E
I
G
A
T
D
Y
W
E
V
G
P
G
K
V
L
T
G
L
C
K
R
T
C
P
D
L
N
L
K
N
I
G
Q
L
D
D
L
N
------
14
PsiBlast_PDB
68.91
40%
-18
- C1 -
-
3H0P
-
FABD_SALTY
A:
[8-295]
---
A
F
V
F
P
G
Q
G
S
Q
S
V
G
M
L
A
E
---
M
A
-
A
N
-
Y
-
P
I
V
-
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
-
Q
-
Q
G
P
A
--
E
-
E
L
N
--
K
T
W
Q
T
Q
P
A
L
L
T
A
S
-
V
A
L
W
R
V
W
-
Q
Q
-
Q
-
G
G
K
M
P
----
A
L
M
A
----
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
N
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
G
M
S
A
I
I
G
L
D
D
A
S
I
A
K
A
C
E
E
S
A
-
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
S
A
P
T
V
P
V
V
N
N
V
-
D
----
V
-
K
-
C
E
T
D
-
A
-
A
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
F
I
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
------------------
38
HHSearch
67.43
39%
-17
- C1 -
-
3K89
1
?
A:
[5-310]
-
T
L
A
F
V
F
P
G
Q
G
S
Q
S
L
G
-
M
L
A
---
E
L
-
S
E
-
L
H
P
Q
I
-
R
E
T
F
A
E
A
S
E
G
A
G
V
D
L
W
A
L
S
-
Q
-
G
G
P
E
--
E
-
M
L
N
--
R
T
E
Y
T
Q
P
A
L
L
A
A
G
-
V
A
V
W
R
L
W
-
T
A
Q
R
-
G
-
Q
R
P
----
A
L
L
A
----
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
A
G
V
G
A
M
A
A
V
L
G
A
E
D
A
V
V
L
E
V
C
A
E
A
A
-
G
S
Q
V
V
V
P
A
N
F
N
S
P
G
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
-
R
G
V
R
K
A
V
-
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
I
P
V
V
Q
N
V
-
D
----
A
-
R
V
H
-
D
G
-
S
-
A
A
I
R
Q
A
L
V
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
Q
G
I
T
R
I
A
E
C
G
P
G
K
V
L
S
G
L
I
K
R
I
D
K
S
L
D
A
R
P
L
A
T
P
A
D
Y
A
G
A
L
D
--
21
PsiBlast_CBE
66.12
35%
5
- C1 -
-
3QAT
1
?
B:
[6-316]
-
G
A
A
F
T
F
P
G
Q
G
S
Q
L
I
G
-
M
G
K
---
V
L
-
T
E
-
Q
-
F
V
A
A
R
M
V
F
E
E
V
D
D
A
L
S
E
K
L
S
D
I
I
-
F
E
G
-
P
A
--
D
-
V
L
T
--
L
T
A
N
A
Q
P
A
L
M
A
V
S
-
M
A
V
I
R
V
M
-
E
Q
-
L
-
G
-
L
N
V
----
E
K
K
V
K
F
V
A
G
H
S
L
G
E
Y
S
A
L
C
A
A
G
T
F
S
L
T
D
T
A
R
L
L
R
I
R
G
N
A
M
Q
A
A
V
A
V
G
E
G
S
M
A
A
L
I
G
L
D
E
K
D
V
E
E
I
C
E
I
V
A
-
E
E
G
L
C
Q
I
A
N
D
N
G
G
G
Q
I
V
I
S
G
E
A
K
A
V
E
T
A
V
E
V
A
S
Q
-
K
G
A
K
R
A
V
-
L
L
P
V
S
A
P
F
H
S
A
L
M
Q
P
A
A
N
A
M
K
N
A
L
L
T
V
N
K
T
A
P
I
V
P
L
I
A
N
V
-
S
----
V
I
P
-
E
-
S
D
-
P
-
E
R
I
V
S
L
L
V
Q
Q
V
T
G
R
V
R
W
R
E
T
I
E
W
I
S
A
N
G
V
N
T
L
F
E
I
G
S
G
K
V
L
T
G
L
A
R
R
I
N
K
D
I
K
A
L
T
V
G
T
A
E
E
I
E
A
A
L
R
V
L
4
PsiBlast_PDB
65.93
38%
-20
- C- -
-
3EZO
-
?
A:
[0-304]
M
K
F
A
F
V
F
P
G
Q
G
S
Q
S
V
G
-
M
L
N
---
A
F
-
A
D
-
V
-
A
V
V
-
R
E
T
L
D
E
A
S
D
A
L
G
Q
D
I
G
K
L
I
-
A
-
D
G
P
A
--
D
-
E
L
N
--
L
T
T
N
T
Q
P
V
M
L
T
A
A
-
Y
A
C
Y
R
A
W
-
Q
Q
-
A
-
G
G
A
Q
P
----
S
I
V
A
----
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
A
I
A
F
R
D
A
L
P
L
V
R
F
R
A
Q
A
M
Q
T
A
V
P
V
G
V
G
G
M
A
A
I
L
G
L
D
D
D
T
V
R
A
V
C
A
E
A
S
-
A
T
G
V
V
E
A
V
N
F
N
A
P
A
Q
V
V
I
A
G
T
K
A
G
I
E
K
A
C
E
I
A
K
E
-
K
G
A
K
R
A
L
-
P
L
P
V
S
A
P
F
H
S
S
L
L
K
P
A
S
D
K
L
R
E
Y
L
A
G
V
D
V
K
A
P
K
I
S
V
V
N
N
I
-
D
----
V
-
A
-
V
-
V
S
-
D
P
A
A
I
K
D
A
L
V
R
Q
A
A
G
P
V
R
W
V
E
C
V
Q
H
I
A
R
E
G
V
T
H
V
I
E
C
G
P
G
K
V
L
A
G
L
T
K
R
I
D
G
N
L
V
G
A
S
V
F
D
P
A
S
L
D
E
A
L
---
15
PsiBlast_PDB
65.89
35%
3
- C1 -
-
3QAT
1
?
A:
[5-316]
M
G
A
A
F
T
F
P
G
Q
G
S
Q
L
I
G
-
M
G
K
---
V
L
-
T
E
-
Q
-
F
V
A
A
R
M
V
F
E
E
V
D
D
A
L
S
E
K
L
S
D
I
I
-
F
E
G
-
P
A
--
D
-
V
L
T
--
L
T
A
N
A
Q
P
A
L
M
A
V
S
-
M
A
V
I
R
V
M
-
E
Q
-
L
-
G
-
L
N
V
----
E
K
K
V
K
F
V
A
G
H
S
L
G
E
Y
S
A
L
C
A
A
G
T
F
S
L
T
D
T
A
R
L
L
R
I
R
G
N
A
M
Q
A
A
V
A
V
G
E
G
S
M
A
A
L
I
G
L
D
E
K
D
V
E
E
I
C
E
I
V
A
-
E
E
G
L
C
Q
I
A
N
D
N
G
G
G
Q
I
V
I
S
G
E
A
K
A
V
E
T
A
V
E
V
A
S
Q
-
K
G
A
K
R
A
V
-
L
L
P
V
S
A
P
F
H
S
A
L
M
Q
P
A
A
N
A
M
K
N
A
L
L
T
V
N
K
T
A
P
I
V
P
L
I
A
N
V
-
S
----
V
I
P
-
E
-
S
D
-
P
-
E
R
I
V
S
L
L
V
Q
Q
V
T
G
R
V
R
W
R
E
T
I
E
W
I
S
A
N
G
V
N
T
L
F
E
I
G
S
G
K
V
L
T
G
L
A
R
R
I
N
K
D
I
K
A
L
T
V
G
T
A
E
E
I
E
A
A
L
R
V
L
2
PsiBlast_PDB
65.65
45%
-
- C1 -
-
3PTW
-
?
A:
[3-308]
-
K
L
G
F
L
F
A
G
Q
G
A
Q
Y
V
G
-
M
G
K
E
F
F
D
N
-
F
E
-
E
-
S
---
K
E
V
F
K
R
S
S
E
A
L
G
I
D
M
E
E
L
C
-
F
-
N
-
D
P
--
E
G
L
L
N
--
K
T
E
F
T
Q
P
A
I
I
T
T
N
-
M
A
I
L
T
A
L
-
D
K
-
L
-
G
-
V
K
S
----
H
I
S
C
----
G
L
S
L
G
E
Y
S
A
L
I
H
S
G
A
I
N
F
E
D
G
V
K
L
V
K
K
R
G
K
F
M
Q
E
A
V
A
E
G
I
G
G
M
V
A
V
L
R
M
T
P
E
Q
V
D
E
I
I
E
K
S
S
-
P
Y
G
I
V
E
G
A
N
Y
N
S
P
G
Q
I
V
I
S
G
E
L
V
A
L
E
K
A
M
E
F
I
K
E
-
V
G
-
G
R
A
I
-
K
L
P
V
S
A
P
F
H
C
S
M
L
Q
P
A
A
E
K
L
E
D
E
L
N
K
I
S
I
N
K
L
N
G
I
V
M
S
N
V
-
K
----
G
-
E
A
Y
-
L
E
-
D
-
D
N
I
I
E
L
L
T
S
Q
V
K
K
P
V
L
F
I
N
D
I
E
K
M
I
E
S
G
V
D
T
F
I
E
I
G
P
G
K
A
L
S
G
F
V
K
K
I
N
K
N
V
T
V
L
N
V
E
D
L
K
S
L
E
K
T
L
S
K
L
47
HHSearch
65.51
39%
4
- C1 -
-
3IM9
-
FABD_STAAM
A:
[11-308]
-
H
M
A
I
I
F
P
G
Q
G
A
Q
K
V
G
-
M
A
Q
---
D
L
-
F
N
-
N
N
D
Q
A
-
T
E
I
L
T
S
A
A
K
T
L
D
F
D
I
L
E
T
M
-
F
-
T
D
E
E
--
G
-
K
L
G
--
E
T
E
N
T
Q
P
A
L
L
T
H
S
-
S
A
L
L
A
A
L
-
K
N
-----
L
N
P
----
D
F
T
M
----
G
H
S
L
G
E
Y
S
S
L
V
A
A
D
V
L
S
F
E
D
A
V
K
I
V
R
K
R
G
Q
L
M
A
Q
A
F
P
T
G
V
G
S
M
A
A
V
L
G
L
D
F
D
K
V
D
E
I
C
K
S
L
S
S
D
D
K
I
I
E
P
A
N
I
N
C
P
G
Q
I
V
V
S
G
H
K
A
L
I
D
E
L
V
E
K
G
K
S
-
L
G
A
K
R
V
M
-
P
L
A
V
S
G
P
F
H
S
S
L
M
K
V
I
E
E
D
F
S
S
Y
I
N
Q
F
E
W
R
D
A
K
F
P
V
V
Q
N
V
-
N
----
A
-
Q
G
E
-
T
D
-
K
-
E
V
I
K
S
N
M
V
K
Q
L
Y
S
P
V
Q
F
I
N
S
T
E
W
L
I
D
Q
G
V
D
H
F
I
E
I
G
P
G
K
V
L
S
G
L
I
K
K
I
N
R
D
V
K
L
T
S
I
Q
T
L
E
D
--------
39
HHSearch
65.04
36%
2
- C1 -
-
3QAT
1
?
A:
[6-315]
-
G
A
A
F
T
F
P
G
Q
G
S
Q
L
I
G
-
M
G
K
---
V
L
-
T
E
-
Q
F
V
A
A
-
R
M
V
F
E
E
V
D
D
A
L
S
E
K
L
S
D
I
I
-
F
-
E
G
P
A
--
D
-
V
L
T
--
L
T
A
N
A
Q
P
A
L
M
A
V
S
-
M
A
V
I
R
V
M
-
E
Q
-
L
-
G
-
L
N
V
EKKV
K
F
V
A
----
G
H
S
L
G
E
Y
S
A
L
C
A
A
G
T
F
S
L
T
D
T
A
R
L
L
R
I
R
G
N
A
M
Q
A
A
V
A
V
G
E
G
S
M
A
A
L
I
G
L
D
E
K
D
V
E
E
I
C
E
I
V
A
-
E
E
G
L
C
Q
I
A
N
D
N
G
G
G
Q
I
V
I
S
G
E
A
K
A
V
E
T
A
V
E
V
A
S
Q
-
K
G
A
K
R
A
V
-
L
L
P
V
S
A
P
F
H
S
A
L
M
Q
P
A
A
N
A
M
K
N
A
L
L
T
V
N
K
T
A
P
I
V
P
L
I
A
N
V
-
S
----
V
-
I
P
E
-
S
D
-
P
-
E
R
I
V
S
L
L
V
Q
Q
V
T
G
R
V
R
W
R
E
T
I
E
W
I
S
A
N
G
V
N
T
L
F
E
I
G
S
G
K
V
L
T
G
L
A
R
R
I
N
K
D
I
K
A
L
T
V
G
T
A
E
E
I
E
A
A
L
R
V
-
5
PsiBlast_PDB
64.10
40%
-30
- C1 -
-
3K89
1
?
A:
[7-294]
---
A
F
V
F
P
G
Q
G
S
Q
S
L
G
-
M
L
A
---
E
L
-
S
E
L
H
-
P
Q
I
-
R
E
T
F
A
E
A
S
E
G
A
G
V
D
L
W
A
L
S
Q
G
-
G
-
P
E
--
E
-
M
L
N
--
R
T
E
Y
T
Q
P
A
L
L
A
A
G
-
V
A
V
W
R
L
W
T
A
Q
-
R
-
G
-
Q
R
P
----
A
L
L
A
----
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
A
G
V
G
A
M
A
A
V
L
G
A
E
D
A
V
V
L
E
V
C
A
E
A
A
-
G
S
Q
V
V
V
P
A
N
F
N
S
P
G
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
-
R
G
V
R
K
A
V
-
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
I
P
V
V
Q
N
V
-
D
----
A
-
R
-
V
-
H
D
G
S
-
A
A
I
R
Q
A
L
V
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
Q
G
I
T
R
I
A
E
C
G
P
G
K
V
L
S
G
L
I
K
R
I
D
K
S
L
------------------
6
PsiBlast_PDB
63.83
40%
-30
- C1 -
-
3R97
1
?
A:
[7-294]
---
A
F
V
F
P
G
Q
G
S
Q
S
L
G
-
M
L
A
---
E
L
-
S
E
L
H
-
P
Q
I
-
R
E
T
F
A
E
A
S
E
G
A
G
V
D
L
W
A
L
S
Q
G
-
G
-
P
E
--
E
-
M
L
N
--
R
T
E
Y
T
Q
P
A
L
L
A
A
G
-
V
A
V
W
R
L
W
T
A
Q
-
R
-
G
-
Q
R
P
----
A
L
L
A
----
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
A
G
V
G
A
M
A
A
V
L
G
A
E
D
A
V
V
L
E
V
C
A
E
A
A
-
G
S
Q
V
V
V
P
A
N
F
N
S
P
G
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
-
R
G
V
R
K
A
V
-
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
I
P
V
V
Q
N
V
-
D
----
A
-
R
-
V
-
H
D
G
S
-
A
A
I
R
Q
A
L
V
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
Q
G
I
T
R
I
A
E
C
G
P
G
K
V
L
S
G
L
I
K
R
I
D
K
S
L
------------------
18
PsiBlast_PDB
60.74
37%
-23
- C1 -
-
5DZ7
3
PKSE_BACSU
A:
[24-299]
----
Y
V
F
P
G
Q
G
S
Q
Q
K
G
-
M
G
Q
---
G
L
-
F
E
-
Q
---
Y
-
Q
H
L
T
D
Q
A
D
Q
I
L
G
Y
S
I
E
K
L
C
---
T
-
E
K
--
S
-
Y
L
D
VN
H
T
E
Y
T
Q
P
A
L
Y
V
V
N
A
L
S
Y
L
K
R
V
-
E
E
-
T
-
G
-
R
K
P
----
D
F
A
A
----
G
H
S
L
G
E
Y
N
A
L
M
A
A
G
A
F
D
F
E
T
G
L
R
L
V
K
K
R
G
E
L
M
G
R
I
T
G
G
G
---
M
A
A
V
I
G
L
S
K
E
Q
V
T
A
V
L
E
E
H
R
-
L
Y
D
I
-
D
V
A
N
E
N
T
P
Q
Q
I
V
I
S
G
P
K
K
E
I
E
K
A
R
A
V
F
E
N
T
K
D
V
K
L
F
H
-
P
L
N
V
S
G
A
F
H
S
R
Y
M
N
E
A
K
Q
V
F
K
Q
Y
I
D
S
F
Q
F
A
P
L
A
I
P
V
I
S
N
V
-
Y
----
A
-
E
-
P
-
Y
H
-
Q
-
D
R
L
K
D
T
L
S
E
Q
M
D
N
T
V
K
W
T
D
S
I
R
F
L
M
G
R
G
E
M
E
F
A
E
I
G
P
G
T
V
L
T
G
L
I
H
R
I
----------------------
19
PsiBlast_PDB
59.96
37%
-29
- C1 -
-
5DZ6
3
PKSC_BACSU
A:
[4-281]
----
Y
V
F
P
G
Q
G
S
Q
K
Q
G
-
M
G
S
---
G
L
-
F
D
-
E
---
F
-
K
E
L
T
D
Q
A
D
E
I
L
G
Y
S
I
K
R
L
C
-
L
---
E
N
PY
S
-
N
L
N
--
K
T
Q
F
T
Q
P
A
L
Y
V
V
N
A
L
S
Y
L
K
K
I
-
R
D
-
E
-
E
-
V
K
P
----
D
F
V
A
----
G
H
S
L
G
E
Y
N
A
L
F
A
A
E
A
F
D
F
E
T
G
L
Q
L
V
R
K
R
G
E
L
M
S
L
I
S
---
N
G
G
M
A
A
V
M
G
L
N
E
E
Q
V
A
K
A
L
K
E
Y
H
-
L
H
D
-
V
D
I
A
N
V
N
A
P
Y
Q
I
V
I
S
G
K
K
D
E
I
E
K
A
A
S
L
F
E
T
-
M
T
E
V
T
M
V
L
P
L
N
V
S
G
A
F
H
S
R
Y
M
N
K
A
K
E
E
F
E
E
F
L
H
A
F
Y
F
S
P
P
S
I
P
V
I
S
N
V
-
Y
----
A
-
K
-
P
-
Y
T
-
Y
-
E
F
M
K
Q
T
L
A
D
Q
I
N
H
S
V
K
W
T
D
S
I
S
Y
L
M
K
K
A
A
M
E
F
E
E
V
G
P
G
N
V
L
T
G
L
I
H
R
I
K
K
--------------------