@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y276: (2018-01-28 )
MTELIIGGVTASTLAEKYKTPLYVYDEEKMRQTMLSFKRGFVSKRFDTKVLYASKAFQTIEMLHLVREYGFGLDVVSGGEIYTALQADFPRDTIYFHGNNKTPEELIYALENDLLHIVADNLMEVELLAELSQRYLKKICIMLRLNVGVEAHTHEYIVTAHIDSKFGMSYESKECQQALQLIKESSYLELEGFHAHIGSQIFDVTAWLAEIDKLTNYLTDFDQPLSLNLGGGFGIRYTQNDQPIPVEEALKKLIEYTEEALEKRKLTIRQLLIEPGRSIVGEAGTTLYTIGFIKKTPHKKYYFVDGGMTDNIRPALYQAEYDCDLAAKLSEEKTEKVTIAGKMCESGDVVIKEAYLPKAESGDLLAVYSTGAYGYSMSSNYNRATRPAVVFVNNGQSRLIVRRQAFSDLLRGEVSYDPS
Atome Classification :
(25 SA)
.........10........20.......----.30........40...----.....------50........60........70........80........90---.........100......---.110.......120---.........130.......140.......150..-.....160.......170.......180....---...190.......200......---.210.......220--.---------.-..----.-.---.-..230.......240......---.250......---.260.......270.......280.......290..-----...-----..300.......310.......320-..-...---.----.--330.....---..340.......350.-------.-------...-.-.360.......370.......380-.......390.-.-.....400.......410.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
E
L
I
IGG
V
T
A
S
T
L
A
E
K
YKT
P
L
Y
V
Y
D
E
E
----
K
M
R
Q
T
M
L
S
F
K
R
G
F
V
SK----RFDT
K
------
V
L
Y
A
S
K
A
F
Q
T
I
E
M
L
H
L
V
R
E
YGFG
L
D
VVSGG
E
I
Y
T
A
L
QADFP----R
D
T
I
Y
F
HGNNK
T
P
E
E
L
I
Y
---
A
L
E
N
D
L
L
H
I
V
A
D
-----
N
L
M
E
V
E
L
L
A
E
L
S
Q
R
Y
L
K
K
I
C
I
M
L
R
LNVG
V
E
AHT
H
-
E
Y
I
V
T
A
HIDSKFGMSY
E
S
K
E
C
Q
Q
A
L
Q
L
I
KESS---
Y
L
E
L
E
G
F
H
A
H
I
G
S
Q
I
F
D
V
T
A
W
L
---
A
E
I
D
K
L
T
N
Y
L
TD----F---------D-Q
P
----
L
-
S
---
L
-NLGGGF
G
I
R
YTQNDQPI
P
V
E
E
---
A
L
K
K
L
I
E
Y
T
E
---
E
A
L
E
K
R
K
L
T
I
R
Q
L
L
IEP
G
R
S
I
VGEAG
T
T
L
Y
T
I
G
F
I
K-----KTP-----H
K
K
Y
Y
F
VDGGMTDNI
R
P
A
L
YQAEYD-
C
D
-
L
A
A
---
K
----L--SEEKT
E
K
V
---
T
I
A
GKMCESG
D
V
V
I
K
E-------A-------YLP-K-AESG
D
L
L
A
V
Y
STGAYGYSMSSNYN-RATR
P
A
V
V
F
V
N-N-GQ
S
R
L
I
V
R
R
Q
A
F
S
D
L
L
RGEVSYDPS
33
HHSearch
92.83
42%
-70
- C3 -
-
2O0T
-
DCDA_MYCTU
B:
[26-448]
---
V
C
I
A
G
I
P
L
T
Q
L
A
Q
E
Y
G
T
P
L
F
V
I
D
E
D
----
D
F
R
S
R
C
R
E
T
A
A
A
F
G
S
G
-------
A
N
------
V
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
S
E
E
G
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
S
F
P
----
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
---
A
V
K
A
G
V
G
H
I
V
V
D
-----
S
M
T
E
I
E
R
L
D
A
I
A
G
E
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
-
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
A
V
R
R
V
F
A
T
D
---
H
L
R
L
V
G
L
H
S
H
I
G
S
Q
I
F
D
V
D
G
F
E
---
L
A
A
H
R
V
I
G
L
L
R
D
VVGE
F
GPEK-----
T
A
Q
I
----
A
-
T
---
V
-
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
P
P
P
I
A
E
---
L
A
A
K
L
G
T
I
V
S
---
D
E
S
T
A
V
G
L
P
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
K
-----
D
V
D
VSATA
H
R
R
Y
V
S
V
D
G
G
M
S
D
N
I
R
T
A
L
Y
G
A
Q
Y
D
-
V
R
-
L
V
S
---
R
----
V
--
S
D
A
P
P
V
P
A
---
R
L
V
G
K
H
C
E
S
G
D
I
I
V
R
D
-------
T
-------
W
V
P
-
D
D
I
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
Y
S
L
S
S
R
Y
N
-
M
V
G
R
P
A
V
V
A
V
H
-
A
-
G
N
A
R
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
V
-----
32
HHSearch
91.77
42%
-66
- C3 -
-
1HKV
4
DCDA_MYCTU
A:
[24-446]
---
V
C
I
A
G
I
P
L
T
Q
L
A
Q
E
Y
G
T
P
L
F
V
I
D
E
D
----
D
F
R
S
R
C
R
E
T
A
A
A
F
G
S
G
-------
A
N
------
V
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
S
E
E
G
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
S
F
P
----
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
---
A
V
K
A
G
V
G
H
I
V
V
D
-----
S
M
T
E
I
E
R
L
D
A
I
A
G
E
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
-
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
A
V
R
R
V
F
A
T
D
---
H
L
R
L
V
G
L
H
S
H
I
G
S
Q
I
F
D
V
D
G
F
E
---
L
A
A
H
R
V
I
G
L
L
R
D
V
V
G
E
F
GPEK-----
T
A
Q
I
----
A
-
T
---
V
-
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
P
P
P
I
A
E
---
L
A
A
K
L
G
T
I
V
S
---
D
E
S
T
A
V
G
L
P
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
K
-----
D
V
D
VSAT
A
H
R
R
Y
V
S
V
D
G
G
M
S
D
N
I
R
T
A
L
Y
G
A
Q
Y
D
-
V
R
-
L
V
S
---
R
----
V
--
S
D
A
P
P
V
P
A
---
R
L
V
G
K
H
C
E
S
G
D
I
I
V
R
D
-------
T
-------
W
V
P
-
D
D
I
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
Y
S
L
S
S
R
Y
N
-
M
V
G
R
P
A
V
V
A
V
H
-
A
-
G
N
A
R
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
V
-----
40
HHSearch
85.36
34%
-104
- C3 -
-
2YXX
1
DCDA_THEMA
A:
[3-385]
---------
I
L
R
K
V
A
E
I
H
G
T
P
T
Y
V
Y
F
E
E
----
T
L
R
K
R
S
R
L
V
K
E
V
F
E
G
V
------
N
L
L
------
P
T
F
A
V
K
A
N
N
N
P
V
L
L
K
I
L
R
E
E
G
F
G
M
D
V
V
T
K
G
E
L
L
A
A
K
L
A
G
V
P
----
S
H
T
V
V
W
N
G
N
G
K
S
R
D
Q
M
E
H
---
F
L
R
E
D
V
R
I
V
N
V
D
-----
S
F
E
E
M
E
I
W
R
E
L
N
P
---
E
G
V
E
Y
F
I
R
V
N
P
E
V
D
A
K
T
H
-
P
H
I
S
T
G
L
K
K
H
K
F
G
I
P
--
L
E
D
L
D
S
F
M
E
R
---
F
R
---
S
M
N
I
R
G
L
H
V
H
I
G
S
Q
I
T
R
V
E
P
F
V
---
E
A
F
S
K
V
V
R
A
S
E
R
----
Y
---------
G
--
F
----
E
-
E
---
I
-
N
I
G
G
G
W
G
I
N
Y
S
G
E
--
E
L
D
L
S
S
---
Y
R
E
K
V
V
P
D
L
K
-----------
R
F
K
R
V
I
V
E
I
G
R
Y
I
V
A
P
S
G
Y
L
L
L
R
V
V
L
V
K
-----
R
R
H
-----
N
K
A
F
V
V
V
D
G
G
M
N
V
L
I
R
P
A
L
Y
S
A
Y
H
R
--
I
-
F
V
L
---
G
-------
K
Q
G
K
E
M
R
A
---
D
V
V
G
P
L
C
E
S
G
D
V
I
A
Y
D
-------
R
-------
E
L
P
-
E
-
V
E
P
G
D
I
I
A
V
E
N
A
G
A
Y
G
Y
T
M
S
N
N
Y
N
-
S
T
T
R
P
A
E
V
L
V
R
-
E
N
G
R
I
S
L
I
R
R
R
E
T
E
M
D
I
F
K
D
V
V
-----
9
PsiBlast_PDB
83.76
32%
-101
- C3 -
-
2YXX
1
DCDA_THEMA
A:
[7-382]
-------------
V
A
E
I
H
G
T
P
T
Y
V
Y
F
E
E
----
T
L
R
K
R
S
R
L
V
K
E
V
F
--
E
----
G
V
N
L
L
------
P
T
F
A
V
K
A
N
N
N
P
V
L
L
K
I
L
R
E
E
G
F
G
M
D
V
V
T
K
G
E
L
L
A
A
K
L
A
G
V
P
----
S
H
T
V
V
W
N
G
N
G
K
S
R
D
Q
M
E
H
---
F
L
R
E
D
V
R
I
V
N
V
D
-----
S
F
E
E
M
E
I
W
R
E
L
N
P
---
E
G
V
E
Y
F
I
R
V
N
P
E
V
D
A
K
T
H
-
P
H
I
S
T
G
L
K
K
H
K
F
G
I
P
L
E
D
L
D
S
-----
F
M
E
R
F
R
---
S
M
N
I
R
G
L
H
V
H
I
G
S
Q
I
T
R
V
E
P
F
V
---
E
A
F
S
K
V
V
R
A
S
E
R
----
Y
---------
G
-
F
E
------
E
---
I
-
N
I
G
G
G
W
G
I
N
Y
S
G
E
E
L
------------
D
L
S
S
Y
R
E
---
K
V
V
P
D
L
K
-
R
F
K
R
V
I
V
E
I
G
R
Y
I
V
A
P
S
G
Y
L
L
L
R
V
V
L
V
K
-----
R
R
H
-----
N
K
A
F
V
V
V
D
G
G
M
N
V
L
I
R
P
A
L
Y
S
A
Y
H
R
-
I
F
-
V
L
G
---
K
----
Q
--
G
K
E
M
--
R
A
---
D
V
V
G
P
L
C
E
S
G
D
V
I
A
Y
D
-------
R
-------
E
L
P
-
E
-
V
E
P
G
D
I
I
A
V
E
N
A
G
A
Y
G
Y
T
M
S
N
N
Y
N
-
S
T
T
R
P
A
E
V
L
V
R
E
N
-
G
R
I
S
L
I
R
R
R
E
T
E
M
D
I
F
K
--------
2
PsiBlast_PDB
82.97
40%
-14
- C3 -
-
2O0T
-
DCDA_MYCTU
A:
[26-449]
---
V
C
I
A
G
I
P
L
T
Q
L
A
Q
E
Y
G
T
P
L
F
V
I
D
E
D
D
F
R
S
R
C
R
E
T
A
A
A
F
G
S
G
-----------
A
N
------
V
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
S
E
E
G
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
S
F
P
----
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
---
A
V
K
A
G
V
G
H
I
V
V
D
-----
S
M
T
E
I
E
R
L
D
A
I
A
G
E
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
-
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
A
V
R
R
V
F
A
T
D
---
H
L
R
L
V
G
L
H
S
H
I
G
S
Q
I
F
D
V
D
G
F
E
---
L
A
A
H
R
V
I
G
L
L
R
D
----
V
V
G
E
FGPEKT
A
-
Q
I
----
A
-
T
---
V
-
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
P
P
P
I
A
E
---
L
A
A
K
L
G
T
I
V
S
---
D
E
S
T
A
V
G
L
P
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
K
D
V
DVS
A
T
A
-----
H
R
R
Y
V
S
V
D
G
G
M
S
D
N
I
R
T
A
L
Y
G
A
Q
Y
D
-
V
R
-
L
V
S
---
R
----
V
--
S
D
A
P
P
V
P
A
---
R
L
V
G
K
H
C
E
S
G
D
I
I
V
R
D
-------
T
-------
W
V
P
D
D
-
I
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
Y
S
L
S
S
R
Y
N
-
M
V
G
R
P
A
V
V
A
V
H
-
A
-
G
N
A
R
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
V
R
----
21
PsiBlast_CBE
82.54
40%
-14
- C3 -
-
1HKV
4
DCDA_MYCTU
B:
[24-446]
---
V
C
I
A
G
I
P
L
T
Q
L
A
Q
E
Y
G
T
P
L
F
V
I
D
E
D
DFRS
R
C
R
E
T
A
A
A
F
G
S
G
-----------
A
N
------
V
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
S
E
E
G
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
S
F
P
----
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
---
A
V
K
A
G
V
G
H
I
V
V
D
-----
S
M
T
E
I
E
R
L
D
A
I
A
G
E
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
-
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
A
V
R
R
V
F
A
T
D
---
H
L
R
L
V
G
L
H
S
H
I
G
S
Q
I
F
D
V
D
G
F
E
---
L
A
A
H
R
V
I
G
L
L
R
D
----
V
VGEFGPEKT
A
-
Q
I
----
A
-
T
---
V
-
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
P
P
P
I
A
E
---
L
A
A
K
L
G
T
I
V
S
---
D
E
S
T
A
V
G
L
P
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
K
DVDVS
A
T
A
-----
H
R
R
Y
V
S
V
D
G
G
M
S
D
N
I
R
T
A
L
Y
G
A
Q
Y
D
-
V
R
-
L
V
S
---
R
----
V
--
S
D
A
P
P
V
P
A
---
R
L
V
G
K
H
C
E
S
G
D
I
I
V
R
D
-------
T
-------
W
V
P
D
D
-
I
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
Y
S
L
S
S
R
Y
N
-
M
V
G
R
P
A
V
V
A
V
H
-
A
-
G
N
A
R
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
V
-----
3
PsiBlast_PDB
82.20
40%
-16
- C3 -
-
1HKW
-
DCDA_MYCTU
A:
[24-446]
---
V
C
I
A
G
I
P
L
T
Q
L
A
Q
E
Y
G
T
P
L
F
V
I
D
E
D
D
F
R
S
R
C
R
E
T
A
A
A
F
G
S
G
-----------
A
N
------
V
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
S
E
E
G
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
S
F
P
----
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
---
A
V
K
A
G
V
G
H
I
V
V
D
-----
S
M
T
E
I
E
R
L
D
A
I
A
G
E
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
-
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
A
V
R
R
V
F
A
T
D
---
H
L
R
L
V
G
L
H
S
H
I
G
S
Q
I
F
D
V
D
G
F
E
---
L
A
A
H
R
V
I
G
L
L
R
D
----
V
V
G
E
FG
P
E
K
T
A
-
Q
I
----
A
-
T
---
V
-
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
P
P
P
I
A
E
---
L
A
A
K
L
G
T
I
V
S
---
D
E
S
T
A
V
G
L
P
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
K
D
V
D
VS
A
T
A
-----
H
R
R
Y
V
S
V
D
G
G
M
S
D
N
I
R
T
A
L
Y
G
A
Q
Y
D
-
V
R
-
L
V
S
---
R
----
V
--
S
D
A
P
P
V
P
A
---
R
L
V
G
K
H
C
E
S
G
D
I
I
V
R
D
-------
T
-------
W
V
P
D
D
-
I
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
Y
S
L
S
S
R
Y
N
-
M
V
G
R
P
A
V
V
A
V
H
-
A
-
G
N
A
R
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
V
-----
1
PsiBlast_PDB
82.02
40%
-15
- C3 -
-
1HKV
4
DCDA_MYCTU
A:
[24-446]
---
V
C
I
A
G
I
P
L
T
Q
L
A
Q
E
Y
G
T
P
L
F
V
I
D
E
D
D
F
R
S
R
C
R
E
T
A
A
A
F
G
S
G
-----------
A
N
------
V
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
S
E
E
G
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
S
F
P
----
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
---
A
V
K
A
G
V
G
H
I
V
V
D
-----
S
M
T
E
I
E
R
L
D
A
I
A
G
E
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
-
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
A
V
R
R
V
F
A
T
D
---
H
L
R
L
V
G
L
H
S
H
I
G
S
Q
I
F
D
V
D
G
F
E
---
L
A
A
H
R
V
I
G
L
L
R
D
----
V
V
G
E
FGPEKT
A
-
Q
I
----
A
-
T
---
V
-
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
P
P
P
I
A
E
---
L
A
A
K
L
G
T
I
V
S
---
D
E
S
T
A
V
G
L
P
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
K
D
V
D
VS
A
T
A
-----
H
R
R
Y
V
S
V
D
G
G
M
S
D
N
I
R
T
A
L
Y
G
A
Q
Y
D
-
V
R
-
L
V
S
---
R
----
V
--
S
D
A
P
P
V
P
A
---
R
L
V
G
K
H
C
E
S
G
D
I
I
V
R
D
-------
T
-------
W
V
P
D
D
-
I
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
Y
S
L
S
S
R
Y
N
-
M
V
G
R
P
A
V
V
A
V
H
-
A
-
G
N
A
R
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
V
-----
6
PsiBlast_PDB
81.49
35%
-57
- C3 -
-
2P3E
-
DCDA_AQUAE
A:
[17-410]
--
E
L
F
I
E
G
V
S
L
K
E
L
A
Q
T
F
G
T
P
L
Y
V
Y
S
S
N
----
F
I
K
E
R
F
E
A
Y
R
K
A
F
P
--------
D
A
L
------
I
C
Y
A
V
K
A
N
F
N
P
H
L
V
K
L
L
G
E
L
G
A
G
A
D
I
V
S
G
G
E
L
Y
L
A
K
K
A
G
I
P
----
P
E
R
I
V
Y
A
G
V
G
K
T
E
K
E
L
T
D
---
A
V
D
S
E
I
L
M
F
N
V
E
-----
S
R
Q
E
L
D
V
L
N
E
I
A
G
K
L
G
K
K
A
R
I
A
I
R
V
N
P
-----------------
S
K
F
G
V
--
D
I
R
E
A
Q
K
E
Y
E
Y
A
S
K
L
E
---
N
L
E
I
V
G
I
H
C
H
I
G
S
Q
I
L
D
I
S
P
Y
R
---
E
A
V
E
K
V
V
S
L
Y
E
S
----
L
---------
T
-
Q
K
GFDI
K
-
Y
---
L
-
D
I
G
G
G
L
G
I
K
Y
K
P
E
D
K
----
E
P
---
A
P
Q
D
L
A
D
L
L
K
---
D
L
L
--
V
K
A
K
I
---
I
L
E
P
G
R
S
I
M
G
N
A
G
I
L
I
T
Q
V
Q
F
L
K
-----
D
K
G
-----
S
K
H
F
I
I
V
D
A
G
M
N
D
L
I
R
P
S
I
Y
N
A
-
Y
H
-
H
I
-
I
P
V
---
E
----
T
--
K
E
---
V
V
A
---
D
I
V
G
P
I
C
E
T
G
D
F
L
A
L
D
-------
R
-------
E
I
E
-
E
-
V
Q
R
G
E
Y
L
A
V
L
S
A
G
A
Y
G
F
A
M
S
S
H
Y
N
-
M
R
P
R
A
A
E
V
L
V
E
-
N
-
G
S
V
K
L
I
R
K
R
E
N
Y
-------------
36
HHSearch
81.03
30%
-67
* C3 *
-
4XG1
5
?
B:
[11-419]
--
R
L
F
V
E
G
L
P
V
E
Q
V
V
K
K
T
G
T
P
A
Y
I
Y
S
R
A
----
T
I
E
R
H
W
Q
A
F
D
S
A
A
G
K
H
------
P
H
L
------
I
C
Y
A
V
K
A
N
S
N
L
A
V
L
N
L
M
A
R
M
G
S
G
F
D
I
V
S
V
G
E
L
M
R
V
I
Q
A
G
G
D
----
P
K
K
I
V
F
S
G
V
G
K
T
E
I
E
I
S
A
---
A
L
Q
A
N
I
M
C
F
N
V
E
-----
S
I
S
E
L
Y
R
I
N
S
V
A
K
A
L
N
V
K
A
P
I
S
I
R
I
N
P
N
I
D
A
G
T
H
-
P
Y
I
S
T
G
L
K
E
N
K
F
G
I
E
--
I
E
Q
A
L
D
V
Y
K
I
A
S
D
L
E
---
F
L
E
I
K
G
V
D
C
H
I
G
S
Q
L
T
E
I
A
P
F
I
---
E
A
L
D
K
L
L
I
L
I
D
L
L
A
E
-
K
---------
G
I
T
I
----
S
-
H
---
L
-
D
L
G
G
G
L
G
V
P
Y
D
D
E
-
T
P
P
E
P
A
E
---
Y
M
T
A
I
I
N
R
M
A
----------
G
R
S
L
K
L
I
F
E
P
G
R
A
I
M
A
N
A
G
V
L
V
T
K
V
E
F
L
K
-----
L
N
-------
K
N
F
A
I
V
D
A
A
M
N
D
L
I
R
P
A
L
Y
S
A
W
Q
N
-
I
I
-
P
L
N
---
T
DYQD
G
--
Q
D
R
P
V
R
S
Y
---
D
I
V
G
P
I
C
E
T
G
D
F
L
G
K
E
-------
R
-------
Q
L
A
---
L
A
E
G
D
Y
L
V
I
R
S
T
G
A
Y
G
S
T
M
S
S
N
Y
N
-
S
R
C
R
A
A
E
I
L
V
D
-
G
-
E
K
A
F
I
V
R
E
R
E
E
L
K
D
L
W
R
G
E
H
I
L
---
46
HHSearch
78.91
34%
-50
- C3 -
-
2P3E
-
DCDA_AQUAE
B:
[18-417]
---
L
F
I
E
G
V
S
L
K
E
L
A
Q
T
F
G
T
P
L
Y
V
Y
S
S
N
----
F
I
K
E
R
F
E
A
Y
R
K
A
F
P
D
A
--------
L
------
I
C
Y
A
V
K
A
N
F
N
P
H
L
V
K
L
L
G
E
L
G
A
G
A
D
I
V
S
G
G
E
L
Y
L
A
K
K
A
G
I
P
----
P
E
R
I
V
Y
A
G
V
G
K
T
E
K
E
L
T
D
---
A
V
D
S
E
I
L
M
F
N
V
E
-----
S
R
Q
E
L
D
V
L
N
E
I
A
G
K
L
G
K
K
A
R
I
A
I
R
V
N
P
-----------------
S
K
F
G
V
D
--
I
R
E
A
Q
K
E
Y
E
Y
A
S
K
L
E
---
N
L
E
I
V
G
I
H
C
H
I
G
S
Q
I
L
D
I
S
P
Y
R
---
E
A
V
E
K
V
V
S
L
Y
E
S
L
T
Q
-
K
---------
G
F
D
I
----
K
-
Y
---
L
-
D
I
G
G
G
L
G
I
K
Y
K
P
E
D
K
E
P
A
P
Q
D
---
L
A
D
L
L
K
D
L
L
E
---
N
-------
V
K
A
K
I
I
L
E
P
G
R
S
I
M
G
N
A
G
I
L
I
T
Q
V
Q
F
L
K
-----
D
K
G
-----
S
K
H
F
I
I
V
D
A
G
M
N
D
L
I
R
P
S
I
Y
N
A
Y
H
H
-
I
I
-
P
V
E
---
T
-------
K
E
R
K
K
V
V
A
---
D
I
V
G
P
I
C
E
T
G
D
F
L
A
L
D
-------
R
-------
E
I
E
-
E
-
V
Q
R
G
E
Y
L
A
V
L
S
A
G
A
Y
G
F
A
M
S
S
H
Y
N
-
M
R
P
R
A
A
E
V
L
V
E
-
N
-
G
S
V
K
L
I
R
K
R
E
N
Y
D
Y
I
V
E
P
S
------
41
HHSearch
78.52
31%
-46
- C3 -
-
2QGH
2
DCDA_HELPX
A:
[23-419]
---------
N
Y
E
E
L
F
Q
T
H
K
T
P
F
Y
L
Y
D
F
D
----
K
I
K
Q
A
F
L
N
Y
K
E
A
F
K
G
R
------
K
S
L
------
I
C
Y
A
L
K
A
N
S
N
L
S
I
L
S
L
L
A
H
L
E
S
G
A
D
C
V
S
I
G
E
I
Q
R
A
L
K
A
G
I
K
----
P
Y
R
I
V
F
S
G
V
G
K
S
A
F
E
I
E
Q
---
A
L
K
L
N
I
L
F
L
N
V
E
-----
S
F
M
E
L
K
T
I
E
T
I
A
Q
S
L
G
I
K
A
R
I
S
I
R
I
N
P
N
I
D
A
K
T
H
-
P
Y
I
S
T
G
L
K
E
N
K
F
G
V
G
--
E
K
E
A
L
E
M
F
L
W
A
K
K
S
A
---
F
L
E
P
V
S
V
H
F
H
I
G
S
Q
L
L
D
L
E
P
I
I
---
E
A
S
Q
K
V
A
K
I
A
K
S
L
I
A
-
L
---------
G
I
D
L
----
R
-
F
---
F
-
D
V
G
G
G
I
G
V
S
Y
E
N
E
-
E
T
I
K
L
Y
D
---
Y
A
Q
G
I
L
N
A
L
Q
---
G
----
L
---
D
L
T
I
I
C
E
P
G
R
S
I
V
A
E
S
G
E
L
I
T
Q
V
L
Y
E
K
-----
K
-------
N
K
R
F
V
I
V
D
A
G
M
N
D
F
L
R
P
S
L
Y
H
A
K
H
A
-
I
R
-
V
I
T
---
P
----
S
-----
E
I
S
P
C
---
D
V
V
G
P
V
C
E
S
S
D
T
F
L
K
D
-------
A
-------
H
L
P
-
E
-
L
E
P
G
D
K
I
A
I
E
K
V
G
A
Y
G
S
S
M
A
S
Q
Y
N
-
S
R
P
K
L
L
E
L
A
L
E
-
D
--
K
I
R
V
I
R
K
R
E
A
L
E
D
L
W
R
L
E
E
-----
7
PsiBlast_PDB
78.14
33%
-40
- C3 -
-
2QGH
2
DCDA_HELPX
A:
[27-418]
-------------
L
F
Q
T
H
K
T
P
F
Y
L
Y
D
F
D
----
K
I
K
Q
A
F
L
N
Y
K
E
A
F
K
G
R
----
K
--
S
L
------
I
C
Y
A
L
K
A
N
S
N
L
S
I
L
S
L
L
A
H
L
E
S
G
A
D
C
V
S
I
G
E
I
Q
R
A
L
K
A
G
I
K
----
P
Y
R
I
V
F
S
G
V
G
K
S
A
F
E
I
E
Q
---
A
L
K
L
N
I
L
F
L
N
V
E
-----
S
F
M
E
L
K
T
I
E
T
I
A
Q
S
L
G
I
K
A
R
I
S
I
R
I
N
P
N
I
D
A
K
T
H
-
P
Y
I
S
T
G
L
K
E
N
K
F
G
V
G
--
E
K
E
A
L
E
M
F
L
W
A
K
K
S
A
---
F
L
E
P
V
S
V
H
F
H
I
G
S
Q
L
L
D
L
E
P
I
I
E
A
S
Q
K
V
A
K
I
A
K
S
L
I
A
----
L
---------
G
-
I
D
----
L
-
R
---
F
F
D
V
G
G
G
I
G
V
S
Y
-
E
N
E
E
T
I
----------
K
L
Y
D
Y
A
Q
G
I
L
N
A
L
Q
G
L
D
L
T
I
---
I
C
E
P
G
R
S
I
V
A
E
S
G
E
L
I
T
Q
V
L
Y
E
K
-----
K
-------
N
K
R
F
V
I
V
D
A
G
M
N
D
F
L
R
P
S
L
Y
H
A
K
H
A
-
I
R
-
V
I
T
---
P
----
S
-----
E
I
S
P
C
---
D
V
V
G
P
V
C
E
S
S
D
T
F
L
K
D
-------
A
-------
H
L
P
-
E
-
L
E
P
G
D
K
I
A
I
E
K
V
G
A
Y
G
S
S
M
A
S
Q
Y
N
-
S
R
P
K
L
L
E
L
A
L
E
-
D
--
K
I
R
V
I
R
K
R
E
A
L
E
D
L
W
R
L
E
------
42
HHSearch
77.56
31%
-44
- C3 -
-
3C5Q
3
DCDA_HELPX
A:
[23-419]
---------
N
Y
E
E
L
F
Q
T
H
K
T
P
F
Y
L
Y
D
F
D
----
K
I
K
Q
A
F
L
N
Y
K
E
A
F
K
G
R
------
K
S
L
------
I
C
Y
A
L
K
A
N
S
N
L
S
I
L
S
L
L
A
H
L
E
S
G
A
D
C
V
S
I
G
E
I
Q
R
A
L
K
A
G
I
K
----
P
Y
R
I
V
F
S
G
V
G
K
S
A
F
E
I
E
Q
---
A
L
K
L
N
I
L
F
L
N
V
E
-----
S
F
M
E
L
K
T
I
E
T
I
A
Q
S
L
G
I
K
A
R
I
S
I
R
I
N
P
N
I
D
A
K
T
H
-
P
Y
L
S
T
G
L
K
E
N
K
F
G
V
G
--
E
K
E
A
L
E
M
F
L
W
A
K
K
S
A
---
F
L
E
P
V
S
V
H
F
H
I
G
S
Q
L
L
D
L
E
P
I
I
---
E
A
S
Q
K
V
A
K
I
A
K
S
L
I
A
-
L
---------
G
I
D
L
----
R
-
F
---
F
-
D
V
G
G
G
I
G
V
S
Y
E
N
E
-
E
T
I
K
L
Y
D
---
Y
A
Q
G
I
L
N
A
L
Q
---
G
----
L
---
D
L
T
I
I
C
E
P
G
R
S
I
V
A
E
S
G
E
L
I
T
Q
V
L
Y
E
K
-----
K
-------
N
K
R
F
V
I
V
D
A
G
M
N
D
F
L
R
P
S
L
Y
H
A
K
H
A
-
I
R
-
V
I
T
---
P
----
S
-----
E
I
S
P
C
---
D
V
V
G
P
V
C
E
S
S
D
T
F
L
K
D
-------
A
-------
H
L
P
-
E
-
L
E
P
G
D
K
I
A
I
E
K
V
G
A
Y
G
S
S
M
A
S
Q
Y
N
-
S
R
P
K
L
L
E
L
A
L
E
-
D
--
K
I
R
V
I
R
K
R
E
A
L
E
D
L
W
R
L
E
E
-----
38
HHSearch
76.95
32%
-49
- C3 -
-
3N2B
-
DCDA_VIBCH
A:
[35-439]
--
Q
L
W
A
E
Q
V
P
L
A
D
L
A
N
Q
Y
G
T
P
L
Y
V
Y
S
R
A
----
T
L
E
R
H
W
H
A
F
D
K
S
V
G
D
Y
------
P
H
L
------
I
C
Y
A
V
K
A
N
S
N
L
G
V
L
N
T
L
A
R
L
G
S
G
F
D
I
V
S
V
G
E
L
E
R
V
L
A
A
G
G
D
----
P
S
K
V
V
F
S
G
V
G
K
T
E
A
E
M
K
R
---
A
L
Q
L
K
I
K
C
F
N
V
E
-----
S
E
P
E
L
Q
R
L
N
K
V
A
G
E
L
G
V
K
A
P
I
S
L
R
I
N
P
D
V
D
A
K
T
H
-
P
Y
I
S
T
G
L
R
D
N
K
F
G
I
T
--
F
D
R
A
A
Q
V
Y
R
L
A
H
S
L
P
---
N
L
D
V
H
G
I
D
C
H
I
G
S
Q
L
T
A
L
A
P
F
I
---
D
A
T
D
R
L
L
A
L
I
D
S
L
K
A
-
E
---------
G
I
H
I
----
R
-
H
---
L
-
D
V
G
G
G
L
G
V
V
Y
------
P
Q
P
S
E
---
Y
A
K
A
L
L
D
R
L
E
---
R
H
------
R
D
L
E
L
I
F
E
P
G
R
A
I
A
A
N
A
G
V
L
V
T
K
V
E
F
L
K
-----
H
T
-------
K
N
F
A
I
I
D
A
A
M
N
D
L
I
R
-------
Q
D
-
I
I
-
P
L
R
---
P
-------
R
Q
G
E
A
Q
T
Y
---
D
L
V
G
P
V
C
E
T
S
D
F
L
G
K
D
-------
R
-------
D
L
V
---
L
Q
E
G
D
L
L
A
V
R
S
S
G
A
Y
G
F
T
M
S
S
N
Y
N
-
T
R
P
R
V
A
E
V
M
V
D
-
G
-
N
K
T
Y
L
V
R
Q
R
E
E
L
S
S
L
W
A
L
E
S
V
L
---
39
HHSearch
76.72
32%
-55
- C3 -
-
3N2B
-
DCDA_VIBCH
B:
[35-439]
--
Q
L
W
A
E
Q
V
P
L
A
D
L
A
N
Q
Y
G
T
P
L
Y
V
Y
S
R
A
----
T
L
E
R
H
W
H
A
F
D
K
S
V
G
D
Y
------
P
H
L
------
I
C
Y
A
V
K
A
N
S
N
L
G
V
L
N
T
L
A
R
L
G
S
G
F
D
I
V
S
V
G
E
L
E
R
V
L
A
A
G
G
D
----
P
S
K
V
V
F
S
G
V
G
K
T
E
A
E
M
K
R
---
A
L
Q
L
K
I
K
C
F
N
V
E
-----
S
E
P
E
L
Q
R
L
N
K
V
A
G
E
L
G
V
K
A
P
I
S
L
R
I
N
P
D
V
-----------------
F
G
I
T
--
F
D
R
A
A
Q
V
Y
R
L
A
H
S
L
P
---
N
L
D
V
H
G
I
D
C
H
I
G
-----
L
A
P
F
I
---
D
A
T
D
R
L
L
A
L
I
D
S
L
K
A
-
E
---------
G
I
H
I
----
R
-
H
---
L
-
D
V
G
G
G
L
G
V
V
Y
-----
P
P
Q
P
S
E
---
Y
A
K
A
L
L
D
R
L
E
---
R
H
------
R
D
L
E
L
I
F
E
P
G
R
A
I
A
A
N
A
G
V
L
V
T
K
V
E
F
L
K
-----
H
T
E
-----
H
K
N
F
A
I
I
D
A
A
M
N
D
L
I
R
P
A
L
Y
Q
A
W
Q
D
-
I
I
-
P
L
R
---
P
-------
R
Q
G
E
A
Q
T
Y
---
D
L
V
G
P
V
C
E
T
S
D
F
L
G
K
D
-------
R
-------
D
L
V
---
L
Q
E
G
D
L
L
A
V
R
S
S
G
A
Y
G
F
T
M
S
S
N
Y
N
-
T
R
P
R
V
A
E
V
M
V
D
-
G
-
N
K
T
Y
L
V
R
Q
R
E
E
L
S
S
L
W
A
L
E
S
V
L
---
10
PsiBlast_PDB
76.46
32%
-50
- C3 -
-
3N2B
-
DCDA_VIBCH
A:
[41-432]
--------
V
P
L
A
D
L
A
N
Q
Y
G
T
P
L
Y
V
Y
S
R
A
----
T
L
E
R
H
W
H
A
F
D
K
S
V
--
G
----
D
Y
P
H
L
------
I
C
Y
A
V
K
A
N
S
N
L
G
V
L
N
T
L
A
R
L
G
S
G
F
D
I
V
S
V
G
E
L
E
R
V
L
A
A
G
G
D
----
P
S
K
V
V
F
S
G
V
G
K
T
E
A
E
M
K
R
---
A
L
Q
L
K
I
K
C
F
N
V
E
-----
S
E
P
E
L
Q
R
L
N
K
V
A
G
E
L
G
V
K
A
P
I
S
L
R
I
N
P
D
V
D
A
K
T
H
-
P
Y
I
S
T
G
L
R
D
N
K
F
G
I
T
F
D
--
R
A
A
Q
V
Y
R
L
A
H
S
L
P
---
N
L
D
V
H
G
I
D
C
H
I
G
S
Q
L
T
A
L
A
P
F
I
---
D
A
T
D
R
L
L
A
L
I
D
S
----
L
---------
K
-
A
E
GIHI
R
-
H
---
L
-
D
V
G
G
G
L
G
V
V
Y
-----
P
Q
P
S
E
Y
---
A
-
K
A
L
L
D
R
L
E
------
R
H
R
D
L
---
E
L
I
F
E
P
G
R
A
I
A
A
N
A
G
V
L
V
T
K
V
E
F
L
K
-----
H
T
-------
K
N
F
A
I
I
D
A
A
M
N
D
L
I
R
-------
Q
D
-
I
--
I
P
L
---
R
----
P
--
R
Q
G
E
A
Q
T
Y
---
D
L
V
G
P
V
C
E
T
S
D
F
L
G
K
D
-------
R
-------
D
L
V
-
L
-
Q
E
-
G
D
L
L
A
V
R
S
S
G
A
Y
G
F
T
M
S
S
N
Y
N
-
T
R
P
R
V
A
E
V
M
V
D
-
G
-
N
K
T
Y
L
V
R
Q
R
E
E
L
S
S
L
----------
30
PsiBlast_CBE
76.42
31%
-45
- C3 -
-
4XG1
5
?
B:
[12-416]
---
L
F
V
E
G
L
P
V
E
Q
V
V
K
K
T
G
T
P
A
Y
I
Y
S
R
A
----
T
I
E
R
H
W
Q
A
F
D
S
A
--
A
G
----
K
H
P
H
L
------
I
C
Y
A
V
K
A
N
S
N
L
A
V
L
N
L
M
A
R
M
G
S
G
F
D
I
V
S
V
G
E
L
M
R
V
I
Q
A
G
G
D
----
P
K
K
I
V
F
S
G
V
G
K
T
E
I
E
I
S
A
---
A
L
Q
A
N
I
M
C
F
N
V
E
-----
S
I
S
E
L
Y
R
I
N
S
V
A
K
A
L
N
V
K
A
P
I
S
I
R
I
N
P
N
I
D
A
G
T
H
-
P
Y
I
S
T
G
L
K
E
N
K
F
G
I
-----
E
I
E
Q
A
L
D
V
Y
K
I
A
S
D
LE
F
L
E
I
K
G
V
D
C
H
I
G
S
Q
L
T
E
I
A
P
F
I
E
--
A
L
D
K
L
L
I
L
I
D
L
L
----
A
---------
E
-
K
G
----
I
-
T
ISH
L
-
D
L
G
G
G
L
G
V
P
Y
D
D
E
T
P
P
E
P
A
-----------
E
Y
M
T
---
A
I
I
N
R
M
A
G
R
S
L
K
L
I
F
E
P
G
R
A
I
M
A
N
A
G
V
L
V
T
K
V
E
F
L
K
-----
L
N
-------
K
N
F
A
I
V
D
A
A
M
N
D
L
I
R
P
A
L
Y
S
A
W
Q
N
I
I
P
-
L
N
T
---
D
----
Y
--
Q
D
G
Q
D
R
P
V
R
S
Y
D
I
V
G
P
I
C
E
T
G
D
F
L
G
K
E
-------
R
-------
Q
L
A
-
L
-
A
E
-
G
D
Y
L
V
I
R
S
T
G
A
Y
G
S
T
M
S
S
N
Y
N
-
S
R
C
R
A
A
E
I
L
V
D
-
G
-
E
K
A
F
I
V
R
E
R
E
E
L
K
D
L
W
R
G
E
------
49
HHSearch
76.28
30%
-52
- C3 -
-
3VAB
3
?
A:
[32-441]
--
V
L
H
A
E
N
V
S
L
P
E
I
A
K
A
V
G
T
P
F
Y
V
Y
S
R
A
----
T
I
E
R
H
F
R
V
F
H
D
A
F
A
D
M
------
D
T
L
------
V
T
Y
A
L
K
A
N
S
N
Q
A
V
L
T
A
L
A
K
L
G
A
G
A
D
T
V
S
Q
G
E
I
R
R
A
L
A
A
G
I
P
----
A
N
R
I
V
F
S
G
V
G
K
T
P
R
E
M
D
F
---
A
L
E
A
G
I
Y
C
F
N
V
E
-----
S
E
P
E
L
E
I
L
S
A
R
A
V
A
A
G
K
V
A
P
V
S
L
R
I
N
P
D
V
D
A
K
T
H
-
A
K
I
---
K
S
E
N
K
F
G
I
P
--
R
D
K
A
R
A
A
Y
A
R
A
A
S
L
P
---
G
L
N
V
V
G
I
D
M
H
I
G
S
Q
I
I
D
L
E
P
F
D
---
N
A
F
A
L
M
A
E
L
V
K
E
L
Q
A
-
D
---------
G
H
N
I
----
R
-
H
---
V
-
D
V
G
G
G
L
G
I
P
Y
R
T
P
--
P
P
P
P
V
A
---
Y
A
Q
I
V
A
K
H
I
K
---
P
L
----
G
---
L
K
T
V
F
E
P
G
R
L
I
V
G
N
A
G
L
L
V
T
E
V
I
F
V
K
-----
E
G
D
-----
A
K
N
F
V
I
V
D
A
A
M
N
D
L
I
R
P
T
L
Y
D
A
F
H
D
-
I
R
-
P
V
I
---
M
P---
N
--
D
N
A
P
R
I
R
A
---
D
F
V
G
P
V
C
E
T
G
D
Y
L
G
L
D
-------
R
-------
E
V
A
-
K
-
P
A
P
G
D
L
I
A
I
C
T
T
G
A
Y
G
A
V
L
S
S
T
Y
N
-
S
R
L
L
I
P
E
V
L
G
D
-
G
-
E
R
Y
H
V
V
R
P
R
R
T
Y
E
E
L
L
A
L
D
S
V
P
D
--
8
PsiBlast_PDB
75.84
32%
-36
- C3 -
-
3C5Q
3
DCDA_HELPX
A:
[27-418]
-------------
L
F
Q
T
H
K
T
P
F
Y
L
Y
D
F
D
----
K
I
K
Q
A
F
L
N
Y
K
E
A
F
K
G
R
----
K
--
S
L
------
I
C
Y
A
L
K
A
N
S
N
L
S
I
L
S
L
L
A
H
L
E
S
G
A
D
C
V
S
I
G
E
I
Q
R
A
L
K
A
G
I
K
----
P
Y
R
I
V
F
S
G
V
G
K
S
A
F
E
I
E
Q
---
A
L
K
L
N
I
L
F
L
N
V
E
-----
S
F
M
E
L
K
T
I
E
T
I
A
Q
S
L
G
I
K
A
R
I
S
I
R
I
N
P
N
I
D
A
K
T
H
-
P
Y
L
S
T
G
L
K
E
N
K
F
G
V
G
--
E
K
E
A
L
E
M
F
L
W
A
K
K
S
A
---
F
L
E
P
V
S
V
H
F
H
I
G
S
Q
L
L
D
L
E
P
I
I
E
A
S
Q
K
V
A
K
I
A
K
S
L
I
A
----
L
---------
G
-
I
D
----
L
-
R
---
F
F
D
V
G
G
G
I
G
V
S
Y
-
E
N
E
E
T
I
----------
K
L
Y
D
Y
A
Q
G
I
L
N
A
L
Q
G
L
D
L
T
I
---
I
C
E
P
G
R
S
I
V
A
E
S
G
E
L
I
T
Q
V
L
Y
E
K
-----
K
-------
N
K
R
F
V
I
V
D
A
G
M
N
D
F
L
R
P
S
L
Y
H
A
K
H
A
-
I
R
-
V
I
T
---
P
----
S
-----
E
I
S
P
C
---
D
V
V
G
P
V
C
E
S
S
D
T
F
L
K
D
-------
A
-------
H
L
P
-
E
-
L
E
P
G
D
K
I
A
I
E
K
V
G
A
Y
G
S
S
M
A
S
Q
Y
N
-
S
R
P
K
L
L
E
L
A
L
E
-
D
--
K
I
R
V
I
R
K
R
E
A
L
E
D
L
W
R
L
E
------
5
PsiBlast_PDB
70.81
36%
19
- C3 -
-
1TUF
2
DCDA_METJA
A:
[16-428]
-----
I
D
G
Y
D
A
I
E
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
----
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
--
K
----
R
W
E
E
E
TG
K
E
F
I
V
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
----
S
K
K
I
V
F
N
G
N
C
K
T
K
E
E
I
I
M
---
G
I
E
A
N
I
R
A
F
N
V
D
-----
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
-
P
K
I
S
T
G
L
K
K
N
K
F
G
L
D
V
E
S
G
I
A
M
K
A
I
K
M
A
L
E
M
E
---
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
---
E
E
T
R
K
V
M
D
F
V
V
E
----
L
---------
K
-
E
E
GIEI
E
-
D
---
V
-
N
L
G
G
G
L
G
I
P
Y
Y
K
-
D
K
Q
I
P
T
Q
K
---
D
L
A
D
A
I
I
N
T
M
---
L
K
Y
-
K
D
K
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
-----
E
T
P
-----
V
T
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
-
Y
H
-
H
I
-
I
N
C
---
K
----
V
--
K
N
E
K
-
E
V
V
---
S
I
A
G
G
L
C
E
S
S
D
V
F
G
R
D
-------
R
-------
E
L
D
-
K
-
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
-
A
R
G
R
P
R
M
V
L
T
S
-
K
-
K
G
V
F
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
-----
34
HHSearch
70.54
34%
5
- C3 -
-
1TUF
2
DCDA_METJA
B:
[13-431]
--
R
F
F
I
D
G
Y
D
A
I
E
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
----
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
K
R
W
EEET
G
K
E
F
I
------
V
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
----
S
K
K
I
V
F
N
G
N
C
K
T
K
E
E
I
I
M
---
G
I
E
A
N
I
R
A
F
N
V
D
-----
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
-
P
K
I
S
T
G
L
K
K
N
K
F
G
L
D
V
E
S
G
I
A
M
K
A
I
K
M
A
L
E
M
E
---
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
---
E
E
T
R
K
V
M
D
F
V
V
E
LKE-
E
---------
G
I
E
I
----
E
-
D
---
V
-
N
L
G
G
G
L
G
I
P
Y
Y
K
D
K
Q
I
P
T
Q
K
D
---
L
A
D
A
I
I
N
T
M
L
---
K
Y
K
D
--
K
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
-----
E
T
P
-----
V
T
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
----
I
I
N
---
C
----
K
--
V
K
N
E
K
E
V
V
---
S
I
A
G
G
L
C
E
S
S
D
V
F
G
R
D
-------
R
-------
E
L
D
-
K
-
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
-
A
R
G
R
P
R
M
V
L
T
S
-
K
-
K
G
V
F
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
V
P
P
--
44
HHSearch
68.79
31%
-19
- C3 -
-
1KNW
2
DCDA_ECOLI
A:
[11-418]
----
D
L
T
A
E
N
L
L
R
L
P
A
E
F
G
C
P
V
W
V
Y
D
A
Q
----
I
I
R
R
Q
I
A
A
L
K
Q
-
F
D
----------
V
------
V
R
F
A
Q
K
A
C
S
N
I
H
I
L
R
L
M
R
E
Q
G
V
K
V
D
S
V
S
L
G
E
I
E
R
A
L
A
A
G
Y
N
PQTH
P
D
D
I
V
F
T
A
D
V
I
D
Q
A
T
L
E
R
---
V
S
E
L
Q
I
-
P
V
N
A
G
-----
S
V
D
M
L
D
Q
L
G
Q
V
S
----
P
G
H
R
V
W
L
R
V
N
P
G
F
G
H
G
H
S
-
Q
K
T
N
T
G
G
E
N
S
K
H
G
I
W
--
Y
T
D
L
P
A
A
L
D
V
I
Q
-
R
H
---
H
L
Q
L
V
G
I
H
M
H
I
G
S
G
V
-
D
Y
A
H
L
E
---
Q
V
C
G
A
M
V
R
Q
V
I
E
----
F
---------
G
Q
D
L
----
Q
-
A
---
I
-
S
A
G
G
G
L
S
V
P
Y
Q
Q
G
E
E
A
V
D
T
E
H
Y
Y
G
L
W
N
A
A
R
E
Q
I
A
---
R
H
L
----
G
H
P
V
K
L
E
I
E
P
G
R
F
L
V
A
Q
S
G
V
L
I
T
Q
V
R
S
V
K
-----
Q
M
G
-----
S
R
H
F
V
L
V
D
A
G
F
N
D
L
M
R
P
A
M
Y
G
S
Y
H
H
-
I
S
-
A
L
A
---
A
DG--
R
SL
E
H
A
P
T
V
E
T
---
V
V
A
G
P
L
C
E
S
G
D
V
F
T
Q
Q
EG
G
N
V
E
T
R
-------
A
L
P
-
E
-
V
K
A
G
D
Y
L
V
L
H
D
T
G
A
Y
G
A
S
M
S
S
N
Y
N
-
S
R
P
L
L
P
E
V
L
F
D
-
N
-
G
Q
A
R
L
I
R
R
R
Q
T
I
E
E
L
L
A
L
E
------
13
PsiBlast_PDB
67.75
31%
-10
- C3 -
-
1KO0
2
DCDA_ECOLI
A:
[20-409]
-------------
L
P
A
E
F
G
C
P
V
W
V
Y
D
A
Q
----
I
I
R
R
Q
I
A
A
L
K
Q
----------
F
D
V
-------
V
R
F
A
Q
K
A
C
S
N
I
H
I
L
R
L
M
R
E
Q
G
V
K
V
D
S
V
S
L
G
E
I
E
R
A
L
A
A
G
Y
N
----
P
Q
T
--------
H
P
D
D
I
V
F
T
AD
V
I
D
Q
A
T
L
E
R
V
S
E
L
QIPV
N
A
G
S
V
D
M
L
D
Q
L
G
Q
-
V
S
P
G
H
R
V
W
L
R
V
N
P
G
F
-
G
H
G
H
S
Q
K
T
N
T
G
G
E
N
S
K
H
G
I
W
Y
--
T
D
L
P
A
A
L
D
V
I
Q
R
H
----
H
L
Q
L
V
G
I
H
M
H
I
G
S
G
V
-
D
Y
A
H
L
E
---
Q
V
C
G
A
M
V
R
Q
V
I
E
----
F
---------
G
-
Q
D
----
L
Q
A
---
I
-
S
A
G
G
G
L
S
V
P
Y
Q
Q
G
E
E
A
V
D
T
E
H
----
Y
Y
G
L
W
N
A
A
R
---
E
Q
I
A
R
H
L
G
H
P
V
K
L
E
I
E
P
G
R
F
L
V
A
Q
S
G
V
L
I
T
Q
V
R
S
V
K
-----
Q
M
G
-----
S
R
H
F
V
L
V
D
A
G
F
N
D
L
M
R
P
A
M
Y
G
S
Y
H
H
-
I
S
A
L
A
A
DGR
S
----
L
--
E
H
A
P
T
V
E
T
---
V
V
A
G
P
L
C
E
S
G
D
V
F
T
Q
Q
-------
E
G
G
N
V
E
T
R
A
L
P
-
E
-
V
K
A
G
D
Y
L
V
L
H
D
T
G
A
Y
G
A
S
M
S
S
N
Y
N
S
R
P
L
L
P
E
V
L
F
-
D
-
N
-
G
Q
A
R
L
I
R
R
R
Q
---------------
12
PsiBlast_PDB
67.30
31%
-10
- C3 -
-
1KNW
2
DCDA_ECOLI
A:
[20-409]
-------------
L
P
A
E
F
G
C
P
V
W
V
Y
D
A
Q
----
I
I
R
R
Q
I
A
A
L
K
Q
----------
F
D
V
-------
V
R
F
A
Q
K
A
C
S
N
I
H
I
L
R
L
M
R
E
Q
G
V
K
V
D
S
V
S
L
G
E
I
E
R
A
L
A
A
G
Y
N
----
P
Q
T
--------
H
P
D
D
I
V
F
T
A
D
V
I
D
Q
A
T
L
E
R
V
S
E
L
QIPV
N
A
G
S
V
D
M
L
D
Q
L
G
Q
-
V
S
P
G
H
R
V
W
L
R
V
N
P
G
F
-
G
H
G
H
S
Q
K
T
N
T
G
G
E
N
S
K
H
G
I
W
Y
--
T
D
L
P
A
A
L
D
V
I
Q
R
H
----
H
L
Q
L
V
G
I
H
M
H
I
G
S
G
V
-
D
Y
A
H
L
E
---
Q
V
C
G
A
M
V
R
Q
V
I
E
----
F
---------
G
-
Q
D
----
L
Q
A
---
I
-
S
A
G
G
G
L
S
V
P
Y
Q
Q
G
E
E
A
V
D
T
E
H
----
Y
Y
G
L
W
N
A
A
R
---
E
Q
I
A
R
H
L
G
H
P
V
K
L
E
I
E
P
G
R
F
L
V
A
Q
S
G
V
L
I
T
Q
V
R
S
V
K
-----
Q
M
G
-----
S
R
H
F
V
L
V
D
A
G
F
N
D
L
M
R
P
A
M
Y
G
S
Y
H
H
-
I
S
A
L
A
A
DGR
S
----
L
--
E
H
A
P
T
V
E
T
---
V
V
A
G
P
L
C
E
S
G
D
V
F
T
Q
Q
-------
E
G
G
N
V
E
T
R
A
L
P
-
E
-
V
K
A
G
D
Y
L
V
L
H
D
T
G
A
Y
G
A
S
M
S
S
N
Y
N
S
R
P
L
L
P
E
V
L
F
-
D
-
N
-
G
Q
A
R
L
I
R
R
R
Q
---------------