@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HDA10_HUMAN: (2017-06-15 )
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA
Atome Classification :
(54 SA)
-------.........10........--20-.........30........40........50........60........70-----..-......80...--.------...--------------.90-----------.........100.......110.......120.......130.......140.......150.......--160-...-.....170.......180.......190.......200.......210.......220.......---230.......240.......250.......260.......270--.......280.......290.----.----.....300.......310.......320.---......330--........340.......350......------.360.......370.......380--------------.......390.......400.......410.......420..---.....430.......440.......450----........460.......470.......480------.......------..490.......500.......------510.......520.......530---------.......540-------.......---.550.......560.......570.......580-----......--...590.......600.......610--.........620.......630.......640.......650.......660.......----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------M
G
T
A
L
V
Y
HEDM
T
A
TRLLWD--D--PECEIE
R
P
E
R
L
T
A
A
L
D
R
L
R
QR
G
L
E
Q
R
C
L
R
LSAREAS
E
E
ELGLVH
S
P
E
Y
V
S
L
-----
V
R
-
E
T
Q
VL
G
K
E
E
L
Q
--
A
------LSG--------------QF------------
D
A
I
Y
FHPST
F
H
C
A
R
L
AAGA
G
L
Q
L
V
D
A
V
L
T
G
A
V
QN
G
L
A
LVRPPGHHGQRAAAN
G
F
C
V
FNN
V
A
I
A
AA
H
A
K
Q
--K-H-G
L
H
-
R
I
L
V
V
D
W
DVHHGQ
G
I
Q
Y
L
FEDDP
S
V
L
Y
F
S
W
H
RYEHG
R
F
WPFLRESDADAVGRGQGL
G
F
T
V
NLPWN---QVGMG
N
A
D
Y
V
A
A
F
L
H
L
L
L
P
L
A
FEFDP
E
L
V
L
V
SAGFDSAIGDPE--GQMQA
T
P
E
C
F
A
H
L
T
Q
L
L
Q
V
LA----G----G
R
V
C
A
V
LEGG
Y
H
L
E
S
L
A
E
S
V
C
M
T
V
Q
T
L
LG---DPAPPLSG---
P
M
A
P
C
Q
S
A
L
E
S
I
Q
S
A
R
AAQAP
H
W
K
S
L
Q
------QQDVTAVPMSPSSHSPEGRPPPLL--------------PGGP
V
C
K
A
AASA
P
S
S
L
LDQPCLCPAPSV
R
T
A
V
A
L
TTP
D
I
T
L
V
---L
P
P
D
V
I
Q
Q
E
A
S
A
L
R
E
E
T
E
A
W
AR
P
H
E
S
L
-----
A
R
E
E
A
L
T
A
L
G
K
L
L
Y
L
L
D
G
M
LDGQVNSGIA--------ATPAS
A
A
------
A
A
T
L
D
V
A
V
R
R
G
L
S
H
G
A
Q
R
L
L
C
V
------
A
LGQLDRPPDLAHDG
R
S
L
W
L
N
I
R---------GK
E
A
A
A
L
S
M
--------
F
HVSTPL---PVMT
G
G
F
L
S
C
I
L
G
L
V
L
P
L
AYGFQP
D
L
V
L
V
A
LG-------PGHGLQ--G
P
H
A
A
L
L
A
A
M
L
R
GLAG
G
R
V
L
A
L
LE----ENST
P
Q
L
A
G
I
L
A
R
V
LNGEAPPSLGPSSVA
S
P
E
D
V
Q
A
L
M
Y
L
R
GQLEPQ
W
K
M
L
QCHPHLVA----
89
HHSearch
85.69
54%
-122
- C3 -
-
5G0G
9
?
A:
[24-379]
--------
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
------
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
-----
M
K
-
S
T
Q
N
M
T
E
E
E
L
K
--
T
------
L
A
E
--------------
K
Y
------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
--
R
-
H
-
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
----
Q
----
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
---
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
------
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
78.62
53%
0
- C- -
-
5G0I
5
?
B:
[40-417]
--------
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
AS
H
--
P
E
C
----
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
-----
M
K
-
S
T
Q
N
M
T
E
E
E
L
K
--
T
------
L
A
E
--------------
K
Y
------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
--
R
-
H
-
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
----
Q
----
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
---
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.62
53%
0
- C- -
-
5G0I
5
?
A:
[40-416]
--------
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
AS
H
--
P
E
C
----
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
-----
M
K
-
S
T
Q
N
M
T
E
E
E
L
K
--
T
------
L
A
E
--------------
K
Y
------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
--
R
-
H
-
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
----
Q
----
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
---
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
76.29
52%
-80
- C3 -
-
5EDU
4
HDAC6_HUMAN (first)
A:
[391-745]
---------
T
G
L
V
Y
D
Q
N
M
M
N
H
C
N
L
W
D
--
S
--
H
H
P
E
V
--
P
Q
R
I
L
R
I
M
C
R
L
E
E
L
G
L
A
G
R
C
L
T
L
T
P
R
P
A
T
E
A
E
L
L
T
C
H
S
A
E
Y
V
G
H
-----
L
R
-
A
T
E
K
M
K
T
R
E
L
H
--
R
------
E
S
S
--------------
N
F
------------
D
S
I
Y
I
C
P
S
T
F
A
C
A
Q
L
A
T
G
A
A
C
R
L
V
E
A
V
L
S
G
E
V
L
N
G
A
A
V
V
R
P
P
G
H
H
A
E
Q
D
A
A
C
G
F
C
F
F
N
S
V
A
V
A
A
R
H
A
Q
T
--
I
-
S
-
G
H
A
L
R
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
M
F
E
D
D
P
S
V
L
Y
V
S
L
H
R
Y
D
H
G
T
F
F
P
M
G
D
E
G
A
S
S
Q
I
G
R
A
A
G
T
G
F
T
V
N
V
A
W
N
---
G
P
R
M
G
D
A
D
Y
L
A
A
W
H
R
L
V
L
P
I
A
Y
E
F
N
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
C
Q
V
S
P
E
G
Y
A
H
L
T
H
L
L
M
G
L
A
----
S
----
G
R
I
I
L
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
A
A
C
T
R
S
L
L
G
---
D
P
P
P
L
L
T
L
---
P
R
P
P
L
S
G
A
L
A
S
I
T
E
T
I
Q
V
H
R
R
Y
W
R
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
HHSearch
75.50
52%
-74
- C3 -
-
5EDU
4
HDAC6_HUMAN (first)
B:
[389-745]
-------
S
R
T
G
L
V
Y
D
Q
N
M
M
N
H
C
N
L
W
D
------
S
H
H
P
E
V
P
Q
R
I
L
R
I
M
C
R
L
E
E
L
G
L
A
G
R
C
L
T
L
T
P
R
P
A
T
E
A
E
L
L
T
C
H
S
A
E
Y
V
G
H
-----
L
R
-
A
T
E
K
M
K
T
R
E
L
H
--
R
------
E
S
S
--------------
N
F
------------
D
S
I
Y
I
C
P
S
T
F
A
C
A
Q
L
A
T
G
A
A
C
R
L
V
E
A
V
L
S
G
E
V
L
N
G
A
A
V
V
R
P
P
G
H
H
A
E
Q
D
A
A
C
G
F
C
F
F
N
S
V
A
V
A
A
R
H
A
Q
T
--
I
-
S
G
H
A
L
-
R
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
M
F
E
D
D
P
S
V
L
Y
V
S
L
H
R
Y
D
H
G
T
F
F
P
M
G
D
E
G
A
S
S
Q
I
G
R
A
A
G
T
G
F
T
V
N
V
A
W
N
---
G
P
R
M
G
D
A
D
Y
L
A
A
W
H
R
L
V
L
P
I
A
Y
E
F
N
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
C
Q
V
S
P
E
G
Y
A
H
L
T
H
L
L
M
G
L
A
----
S
----
G
R
I
I
L
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
A
A
C
T
R
S
L
L
G
---
D
P
P
P
L
L
T
-----
R
P
P
L
S
G
A
L
A
S
I
T
E
T
I
Q
V
H
R
R
Y
W
R
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Fugue
75.02
39%
-6
- C3 -
-
5G0J
9
?
A:
[17-772]
VQGKS
K
A
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
--
A
SH
P
E
C
----
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
-----
M
K
-
S
T
Q
N
M
T
E
E
E
L
K
--
T
------
L
A
E
--------------
K
Y
------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
--
R
-
H
-
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
----
Q
----
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
---
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
TFEGGP
L
S
E
V
S
P
L
P
A
P
V
C
A
E
V
K
V
S
S
P
I
T
G
L
V
Y
D
QRMMLHHNMWD
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
HS
S
K
H
I
S
I
I
K
S
S
E
H
M
K
P
R
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
NE
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
IVRPPGHH
A
E
K
D
T
A
C
GFCFFN
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
WDVHH
G
N
G
T
Q
H
I
F
E
E
---
D
D
S
V
L
Y
I
S
L
H
RYEDGAFFP
N
S
E
D
A
N
Y
D
K
VGLGKGRG
Y
N
V
N
I
P
W
NGG
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
FDAARGD
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
A
G
R
V
L
I
I
L
E
G
GYN
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
V
N
I
P
E
S
L
RLSL
5
PsiBlast_PDB
74.78
52%
-75
- C3 -
-
5EDU
4
HDAC6_HUMAN (first)
B:
[391-745]
---------
T
G
L
V
Y
D
Q
N
M
M
N
H
C
N
L
W
D
--
S
--
H
H
P
E
V
--
P
Q
R
I
L
R
I
M
C
R
L
E
E
L
G
L
A
G
R
C
L
T
L
T
P
R
P
A
T
E
A
E
L
L
T
C
H
S
A
E
Y
V
G
H
-----
L
R
-
A
T
E
K
M
K
T
R
E
L
H
--
R
------
E
S
S
--------------
N
F
------------
D
S
I
Y
I
C
P
S
T
F
A
C
A
Q
L
A
T
G
A
A
C
R
L
V
E
A
V
L
S
G
E
V
L
N
G
A
A
V
V
R
P
P
G
H
H
A
E
Q
D
A
A
C
G
F
C
F
F
N
S
V
A
V
A
A
R
H
A
Q
T
--
I
-
S
-
G
H
A
L
R
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
M
F
E
D
D
P
S
V
L
Y
V
S
L
H
R
Y
D
H
G
T
F
F
P
M
G
D
E
G
A
S
S
Q
I
G
R
A
A
G
T
G
F
T
V
N
V
A
W
N
---
G
P
R
M
G
D
A
D
Y
L
A
A
W
H
R
L
V
L
P
I
A
Y
E
F
N
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
C
Q
V
S
P
E
G
Y
A
H
L
T
H
L
L
M
G
L
A
----
S
----
G
R
I
I
L
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
A
A
C
T
R
S
L
L
G
---
D
P
P
P
L
L
T
-----
R
P
P
L
S
G
A
L
A
S
I
T
E
T
I
Q
V
H
R
R
Y
W
R
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
HHSearch
73.63
45%
-69
- C3 -
-
5G0H
14
?
A:
[406-763]
--------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
------
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
--
I
T
R
-
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------
V
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
HHSearch
73.11
46%
-69
- C3 -
-
5EEI
12
?
A:
[8-364]
-------
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
------
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
--
I
T
R
-
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
72.64
46%
-64
- C3 -
-
5EEM
3
?
A:
[10-363]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
-----
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
72.28
46%
-63
- C3 -
-
5EF8
7
?
B:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
IT
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
72.03
46%
-61
- C3 -
-
5EEN
5
?
A:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.98
46%
-62
- C3 -
-
5EF7
4
?
A:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.97
46%
-61
- C3 -
-
5EEN
4
?
B:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
IT
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
-------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
71.94
46%
-60
- C3 -
-
5EFH
9
?
A:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.82
46%
-63
- C3 -
-
5EFG
4
?
D:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
IT
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
71.73
46%
-60
- C3 -
-
5EEI
8
?
B:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
IT
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
71.64
46%
-61
- C3 -
-
5EFJ
9
?
D:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
IT
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
-
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
71.58
45%
-60
- C3 -
-
5EFN
6
?
B:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
IT
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.58
53%
-42
- C3 -
-
5EEF
7
?
A:
[9-363]
--------
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
----S-
H
--
P
E
C
----
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
-----
M
K
-
S
T
Q
N
M
T
E
E
E
L
K
--
T
------
L
A
E
--------------
K
Y
------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
--
R
-
H
-
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
----
Q
----
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
---
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
71.56
45%
-61
- C3 -
-
5EFN
5
?
A:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
71.53
46%
-61
- C3 -
-
5EF7
5
?
B:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
IT
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
-----
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.38
46%
-61
- C3 -
-
5EEM
5
?
B:
[10-363]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
IT
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
------
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.92
46%
-61
- C3 -
-
5EF8
6
?
A:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
70.90
45%
-60
- C3 -
-
5EFK
8
?
B:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
F
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
-
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.62
46%
-60
- C3 -
-
5EEK
30
?
A:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
-----
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.95
46%
-58
- C3 -
-
5EFB
4
?
D:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
IT
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
-----
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.24
46%
-61
- C3 -
-
5EFH
7
?
D:
[10-364]
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
--
H
H
P
E
L
--
P
Q
R
I
S
R
I
F
-
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
-----
I
K
-
S
S
E
H
M
K
P
R
D
L
N
--
R
------
L
G
D
--------------
E
Y
------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
IT
R
-
E
-
S
L
--
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
---
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
--
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
69.12
53%
-21
- C3 -
-
5EEF
6
?
B:
[9-363]
--------
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
AS
H
--
P
E
C
----
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
-----
M
K
-
S
T
Q
N
M
T
E
E
E
L
K
--
T
------
L
A
E
--------------
K
Y
------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
--
R
-
H
-
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
----
Q
----
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
---
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
67.78
53%
-17
- C3 -
-
5G0G
9
?
A:
[24-378]
--------
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
AS
H
--
P
E
C
----
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
-----
M
K
-
S
T
Q
N
M
T
E
E
E
L
K
--
T
------
L
A
E
--------------
K
Y
------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
--
R
-
H
-
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
----
Q
----
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
---
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
64.28
35%
-114
- C3 -
-
5JI5
6
?
A:
[10-314]
--------
A
T
G
F
Y
S
H
A
D
C
L
Q
H
E
M
G
--------
Q
W
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
L
A
D
E
A
A
L
L
R
V
H
T
K
A
H
V
D
Y
-----
L
R
-
A
R
S
P
Q
S
G
-------------
Y
A
E
--------------
I
D
------------
P
D
T
S
M
N
P
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
--
V
-
H
-
K
L
E
-
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
---
P
F
Y
P
F
T
G
A
--------
D
N
Q
A
P
N
M
C
N
V
P
I
A
---
A
-
R
S
K
G
M
V
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
E
D
D
L
--
G
N
M
A
L
V
E
D
D
Y
A
W
I
T
Q
Q
I
R
L
V
A
D
K
YA
K
----
G
R
I
V
S
C
L
E
G
G
Y
N
L
S
A
L
G
R
S
V
V
A
H
V
R
A
L
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
64.15
37%
-79
- C3 -
-
2VQV
8
B:
[10-394]
---------
T
G
L
V
Y
D
T
L
M
L
K
-----------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
L
-----
L
Y
-
G
T
N
P
L
----------------------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
--
R
-
L
-
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
GGL
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
PL
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
----
G
----
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
---
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------
R
T
T
S
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
64.14
38%
-34
- C3 -
-
3C10
5
HDAC7_HUMAN
A:
[40-420]
---------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
--
D
--
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
-----
L
Y
-
G
T
N
P
L
S
R
L
K
L
D
N
G
K
------
L
A
G
L
L
A
QVMLPCGGVGV
D
T
------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
--
Q
-
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
GGL
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
PL
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
----
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
---
N
R
V
D
P
L
S
E
EGW
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
64.08
37%
-29
- C3 -
-
5A2S
4
B:
[10-388]
---------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
--
S
--
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
YGTNP
A
N
-
R
Q
K
L
D
S
K
K
L
L
G
--
S
------
L
A
S
--------------
V
F
VRLPCGGVGVDS
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
--
R
-
L
-
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
GGL
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
PL
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
----
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
---
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
63.82
37%
-79
- C3 -
-
2VQV
6
HDAC4_HUMAN
A:
[10-394]
---------
T
G
L
V
Y
D
T
L
M
L
K
------------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
L
-----
L
Y
-
G
T
N
P
-----------------------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
--
R
-
L
-
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
GGL
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
PL
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
----
G
----
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
---
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------
R
T
T
S
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
63.02
38%
-32
- C3 -
-
3C0Z
5
HDAC7_HUMAN
A:
[40-420]
---------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
--
D
--
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
-----
L
Y
-
G
T
N
P
L
S
R
L
K
L
D
N
G
K
------
L
A
G
L
L
A
QVMLPCGGVGV
D
T
------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
--
Q
-
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
GGL
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
PL
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
----
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
---
N
R
V
D
P
L
S
E
EGW
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
62.70
37%
-50
- C3 -
-
4CBT
3
HDAC4_HUMAN
B:
[10-388]
---------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
--
S
--
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
L
-----
L
Y
-
G
T
N
P
-----------------------------------S-----------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
--
R
-
L
-
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
GGL
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
PL
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
----
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N--
D
P
L
P
E
K
V
L
---
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
62.27
38%
-31
- C3 -
-
3ZNS
5
HDAC7_HUMAN
B:
[40-420]
---------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
--
D
--
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
-----
L
Y
-
G
T
N
P
L
S
R
L
K
L
D
N
G
K
------
L
A
G
L
L
A
QVMLPCGGVGV
D
T
------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
--
Q
-
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
GGL
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
PL
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
----
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
---
N
R
V
D
P
L
S
E
EGW
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
61.77
37%
-28
- C3 -
-
5A2S
4
HDAC4_HUMAN
A:
[10-388]
---------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
--
S
--
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
A
N
-
R
Q
K
L
D
S
K
K
L
L
G
--
S
------
L
A
S
--------------
V
F
V
R
L
PCGGVGVDS
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
--
R
-
L
-
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
GGL
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
PL
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
----
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
---
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
61.38
37%
-75
- C3 -
-
4CBT
3
C:
[10-389]
---------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
--------
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
L
-----
L
Y
-
G
T
N
P
L
-----------------------------------------------
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
--
R
-
L
---
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
GGL
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
PL
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
----
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NE------
K
V
L
---
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
59.96
37%
-37
- C3 -
-
2VQM
5
A:
[10-394]
---------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
-----------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
L
-----
L
Y
-
G
T
N
P
L
N
R
Q
------K
K
L
L
G
S
L
A
S
--------------
V
F
VRLPCGGVGVDS
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
--
R
-
L
-
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
GGL
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
PL
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
----
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
---
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------
R
T
T
S
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
59.37
38%
-15
- C3 -
-
3C10
5
HDAC7_HUMAN
B:
[40-420]
---------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
--
D
--
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
-----
L
Y
-
G
T
N
P
L
S
-----------------VMLPCGGVGV----
D
T
------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
--
Q
-
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
GGL
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
PL
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
----
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
---
N
R
V
D
P
L
S
E
EGW
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
59.25
38%
-16
- C3 -
-
3ZNR
5
HDAC7_HUMAN
A:
[40-420]
---------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
--
D
--
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
-----
L
Y
-
G
T
N
P
L
S
-----------------VMLPCGGVGV----
D
T
------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
--
Q
-
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
GGL
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
PL
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
----
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
---
N
R
V
D
P
L
S
E
EGW
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
59.04
38%
-14
- C3 -
-
3C0Z
5
HDAC7_HUMAN
B:
[40-420]
---------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
--
D
--
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
-----
L
Y
-
G
T
N
P
L
S
-----------------VMLPCGGVGV----
D
T
------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
--
Q
-
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
GGL
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
PL
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
----
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
---
N
R
V
D
P
L
S
E
EGW
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
58.71
38%
-16
* C3 *
-
3ZNS
5
HDAC7_HUMAN
A:
[40-420]
---------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
--
D
--
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
-----
L
Y
-
G
T
N
P
L
S
-----------------VMLPCGGVGV----
D
T
------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
--
Q
-
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
GGL
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
PL
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
----
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
---
N
R
V
D
P
L
S
E
EGW
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
58.57
37%
-43
- C3 -
-
2VQQ
6
B:
[10-394]
---------
T
G
L
V
Y
D
T
L
M
L
K
H
------------------
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
L
-----
L
Y
-
G
T
N
P
L
----------------------------------DS----------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
--
R
-
L
-
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
GGL
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
PL
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
----
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
---
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------
R
T
T
S
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
58.55
37%
-42
- C3 -
-
2VQO
6
B:
[10-394]
---------
T
G
L
V
Y
D
T
L
M
L
K
-----------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
L
-----
L
Y
-
G
T
N
P
L
----------------------------------DS----------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
--
R
-
L
-
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
GGL
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
PL
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
----
G
----
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
---
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------
R
T
T
S
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
58.40
37%
-31
- C3 -
-
2VQJ
9
A:
[10-394]
---------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
--
S
--
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
L
-----
L
Y
-
G
T
N
P
L
N
R
Q
K
L
D
--
S
K
K
L
L
G
S
L
A
S
--------------
V
F
VRLPCGGVGVDS
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
--
R
-
L
-
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
GGL
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
PL
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
----
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
---
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------
R
T
T
S
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
57.80
38%
-14
- C3 -
-
3C10
5
C:
[40-419]
---------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
--
D
--
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
-----
L
Y
-
G
T
N
P
-------------------LPCGGVGV------
D
T
------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
--
Q
-
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
GGL
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
PL
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
----
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
---
N
R
V
D
P
L
S
E
EGW
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
57.58
37%
-27
- C3 -
-
2VQO
7
HDAC4_HUMAN
A:
[10-394]
---------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
----------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
L
-----
L
Y
-
G
T
N
P
L
----------------------------------VDS---------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
--
R
-
L
-
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
GGL
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
PL
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
----
G
----
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
---
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------
R
T
T
S
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
57.23
38%
-13
- C3 -
-
3ZNS
5
C:
[40-419]
---------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
--
D
--
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
-----
L
Y
-
G
T
N
P
-------------------LPCGGVGV------
D
T
------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
--
Q
-
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
GGL
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
PL
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
----
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
---
N
R
V
D
P
L
S
E
EGW
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
56.18
38%
-13
- C3 -
-
3C0Z
5
C:
[40-419]
---------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
--
D
--
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
-----
L
Y
-
G
T
N
P
-------------------LPCGGVGV------
D
T
------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
--
Q
-
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
GGL
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
PL
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
----
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
---
N
R
V
D
P
L
S
E
EGW
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
55.79
37%
-28
- C3 -
-
2VQQ
7
HDAC4_HUMAN
A:
[10-394]
---------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
---------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
L
-----
L
Y
-
G
T
N
P
L
----------------------------------VDS---------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
--
R
-
L
-
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
GGL
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
PL
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
----
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
---
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------
R
T
T
S
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
53.50
34%
-57
- C3 -
-
5JI5
6
?
A:
[10-312]
--------
A
T
G
F
Y
S
H
A
D
C
L
Q
H
E
M
G
Q
W
--
H
--
P
E
C
----
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
L
A
D
E
A
A
L
L
R
V
H
T
K
A
H
V
D
Y
-----
L
R
A
R
S
P
Q
S
G
Y
A
E
I
D
--
P
------
D
T
S
--------------------------------
M
N
P
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
--
V
-
H
-
K
L
E
-
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
P
---
F
Y
P
F
--------
T
G
A
D
N
Q
A
P
N
M
C
N
V
P
I
A
---
A
R
S
K
G
M
V
V
R
E
A
I
D
M
-
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
E
D
D
L
--
G
N
M
A
L
V
E
D
D
Y
A
W
I
T
Q
Q
I
R
L
V
A
----
D
K
YAK
G
R
I
V
S
C
L
E
G
G
Y
N
L
S
A
L
G
R
S
V
V
A
H
V
R
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------