@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HDA11_HUMAN: (2017-06-15 )
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
Atome Classification :
(20 SA)
.........10........20........30........40........50........-60-----...-----.....70........80.......-----.90----..---.---------......---100.-----....--...110.......120.......130--.--.--.--......140.......150.......160.......-170.......180.......190.......200.--.---..-------...210..--..---.---------.---------...220-----------....-.---..230.......240.......250.......260.......270..-----.....280.----......290.......300..-.-..-..310.......320--..-----...--...330.......340-......---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
ML
H
T
T
Q
L
Y
Q
HVPETRW
P
I
V
YSPRY
N
I
T
F
M
GLEKLHPFDAG
K
W
G
K
V
I
N
F
L
K
E
E
KLLSD
S
M
-
L
V
-----
E
AR-----EASEE
D
L
L
V
V
H
T
R
R
Y
L
N
E
L
K
W
S
F
A
-----
V
A
-----TI---T---------EIP
P
V
I
---F
L
-
P
-----
N
F
L
V
--
Q
R
K
V
L
R
P
L
RTQTG
G
T
I
M
A
G
K
L
A
V
E----R--G--
W
--
A
I
NVGGGFHHCSSDRGG
G
F
C
A
Y
A
D
I
T
L
A
I
K
F
L
F
E
R
V
-EGIS
R
A
T
I
I
D
L
DAHQGNGHERDFMDD
K
R
V
Y
I
M
D
V
--Y---NR-------HIYP--
G
D
--
R
F
---
A
---------
K
---------
Q
A
I
R
R
K
-----------
V
E
L
E-W---GTE
D
D
E
Y
L
D
K
V
E
R
N
I
K
K
S
L
Q
E
HLP
D
V
V
V
YNAGTDILEGDRLG
G
L
SIS-----
P
A
GIV
K
R
D
E
----
L
V
F
R
M
VRGRRV
P
I
L
M
VTSGGY-
Q
-
K
R
-
T
A
R
I
I
A
D
S
I
L
N
L
FG---LG-----LIG--PESPSVSAQNSDTPL--LPPAVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Fugue
70.62
26%
-39
- C5 -
-
4QA5
9
HDAC8_HUMAN
A:
[14-377]
---------
L
V
P
----
V
Y
I
Y
S
P
E
Y
V
S
M
C
D
S
L
A
K
I
----
P
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
H
K
Q
M
R
-
I
V
-----
K
P
K
-----
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
S
Q
-----
E
G
-----
D
D
---
D
---------
H
P
D
S
I
E
---
Y
G
-
L
-----
G
Y
D
C
PA
T
E
G
I
F
D
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
----
G
MC
K
--
V
--
A
I
N
W
S
G
G
W
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
F
-
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
T
F
S
F
T
S
K
V
M
T
V
S
L
--
H
K
F
-
S
P
-------
G
F
F
P
--
G
T
--
G
D
---
V
---------
S
---------
D
V
G
L
G
K
GRYY
S
V
N
----
V
P
I
Q
-
D
---
G
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
M
C
S
F
N
M
T
-----
P
V
G
I
G
K
C
L
K
----
Y
I
L
Q
W
----
Q
L
A
T
L
I
L
G
G
G
G
F
N
L
-
A
N
-
T
A
R
C
W
T
Y
L
T
G
V
I
L
G
---
K
T
-----
L
S
S
EI
P
D
H
E
F
F
T
A
Y
G
P
D
Y
V
L
E
I
T
P
S
C
R
P
DRNE
P
H
R
I
Q
Q
I
L
N
Y
I
K
G
N
L
K
HVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
68.17
23%
-39
- C5 -
-
5DC8
4
HDAC8_HUMAN
A:
[14-326]
-------------
L
V
P
V
Y
I
Y
S
P
E
Y
V
S
M
C
----
D
S
L
A
K
I
P
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
H
K
Q
M
R
-
I
V
-----
K
P
K
-----
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
S
Q
-----
E
G
-----
D
D
---
D
HP-------
D
S
I
E
Y
G
---
L
G
-
Y
-----
D
C
P
A
--
T
E
G
I
F
D
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
GM--
C
--
K
--
V
--
A
I
N
W
S
G
G
W
A
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
----
F
E
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
--
H
---
K
F
S
P-----
G
F
F
P
--
G
T
--
G
D
---
V
---------
S
DVGLGKG--
R
Y
Y
S
V
N
-----------
V
P
I
Q
-
D
---
G
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
M
C
S
F
N
M
T
-----
P
V
G
I
G
K
C
L
K
----
Y
I
L
Q
W
----
Q
L
A
T
L
I
L
G
G
G
G
F
-
N
-
L
A
N
T
A
R
C
W
T
Y
L
T
G
V
I
L
G
---
K
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
67.01
26%
13
- C5 -
-
5G0J
4
?
A:
[45-355]
----------------------------------
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
-
Q
V
-----
E
A
R
-----
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
-----
M
T
E
E
E
L
K
T
L
---
A
---------
E
K
Y
D
S
V
---
Y
L
H
P
-----
G
F
F
S
--
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
--
R
----
N
--
G
--
F
--
S
I
N
R
P
P
G
-
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
--
H
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
--
H
---
R
Y
EDGSFWP
H
L
K
E
--
S
D
--
S
S
SVG
S
---------
G
---------
A
G
Q
G
Y
N
-----------
I
N
L
P
-
W
NKV
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
G
G
M
Q
V
S
-----
P
E
C
F
S
I
L
T
H
----
M
L
K
G
V
A
Q
G
R
---
L
V
L
A
L
E
G
G
Y
-
N
L
Q
S
-
T
A
E
G
V
C
A
S
M
R
S
L
-----
L
G
-----
D
P
C
--
P
H
L
P
S
S
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
66.37
26%
10
- C5 -
-
5G0I
5
?
A:
[60-392]
----------------------------------
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
-
Q
V
-----
E
A
R
-----
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
-----
M
T
E
E
E
L
K
T
L
---
A
---------
E
K
Y
D
S
V
---
Y
L
H
P
-----
G
F
F
S
--
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
--
R
----
N
--
G
--
F
--
S
I
N
R
P
P
G
-
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
--
H
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
--
H
---
R
Y
EDGSFWP
H
L
K
E
--
S
D
--
S
S
SVG
S
---------
G
---------
A
G
Q
G
Y
N
-----------
I
N
L
P
-
W
NKV
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
G
G
M
Q
V
S
-----
P
E
C
F
S
I
L
T
H
----
M
L
K
G
V
A
Q
G
R
---
L
V
L
A
L
E
G
G
Y
-
N
L
Q
S
-
T
A
E
G
V
C
A
S
M
R
S
L
-----
L
G
-----
D
P
C
--
P
H
L
P
S
S
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.32
26%
11
- C5 -
-
5EEF
7
?
A:
[29-339]
----------------------------------
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
-
Q
V
-----
E
A
R
-----
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
-----
M
T
E
E
E
L
K
T
L
---
A
---------
E
K
Y
D
S
V
---
Y
L
H
P
-----
G
F
F
S
--
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
--
R
----
N
--
G
--
F
--
S
I
N
R
P
P
G
-
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
--
H
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
--
H
---
R
Y
EDGSFWP
H
L
K
E
--
S
D
--
S
S
SVG
S
---------
G
---------
A
G
Q
G
Y
N
-----------
I
N
L
P
-
W
NKV
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
G
G
M
Q
V
S
-----
P
E
C
F
S
I
L
T
H
----
M
L
K
G
V
A
Q
G
R
---
L
V
L
A
L
E
G
G
Y
-
N
L
Q
S
-
T
A
E
G
V
C
A
S
M
R
S
L
-----
L
G
-----
D
P
C
--
P
H
L
P
S
S
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.25
26%
8
- C5 -
-
5G0G
8
?
A:
[44-354]
----------------------------------
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
-
Q
V
-----
E
A
R
-----
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
-----
M
T
E
E
E
L
K
T
L
---
A
---------
E
K
Y
D
S
V
---
Y
L
H
P
-----
G
F
F
S
--
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
--
R
----
N
--
G
--
F
--
S
I
N
R
P
P
G
-
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
--
H
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
--
H
---
R
Y
EDGSFWP
H
L
K
E
--
S
D
--
S
S
SVG
S
---------
G
---------
A
G
Q
G
Y
N
-----------
I
N
L
P
-
W
NKV
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
G
G
M
Q
V
S
-----
P
E
C
F
S
I
L
T
H
----
M
L
K
G
V
A
Q
G
R
---
L
V
L
A
L
E
G
G
Y
-
N
L
Q
S
-
T
A
E
G
V
C
A
S
M
R
S
L
-----
L
G
-----
D
P
C
--
P
H
L
P
S
S
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
66.05
23%
-41
- C5 -
-
5G0G
8
?
A:
[21-346]
-----------
K
A
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
-
Q
V
-----
E
A
R
-----
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
-----
M
T
-----
E
E
---
E
---------
L
K
T
L
A
E
---
K
Y
-
D
-----
S
V
Y
L
--
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
SQLR
N
--
G
--
F
--
S
I
N
R
P
P
G
-
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
--
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
--
H
---
R
Y
EDG----
S
F
W
P
--
H
L
--
K
E
---
S
DSSSVGSGA
G
---------
Q
G
Y
N
I
N
-----------
L
P
W
N
K
V
---
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
G
G
M
Q
V
S
-----
P
E
C
F
S
I
L
T
H
----
M
L
K
G
V
A
---
Q
G
R
L
V
L
A
L
E
G
G
Y
-
N
-
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
-----
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
66.00
25%
-6
- C5 -
-
4QA2
5
HDAC8_HUMAN
A:
[19-314]
------------------
I
Y
S
P
E
Y
V
S
M
C
D
S
L
A
K
I
P
-----
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
H
K
Q
M
R
I
V
-----
K
P
K
-----
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
-
K
V
S
-----
Q
E
-----
G
--------------------YG-
L
G
-
Y
-----
D
C
P
A
--
T
E
G
I
F
D
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
----
G
--
M
--
C
K
V
A
I
N
W
S
G
G
W
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
F
-
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
---
S
P
-------
G
F
F
P
--
G
T
--
G
D
---
V
---------
S
---------
D
V
G
L
G
K
GRYY
S
V
N
----
V
P
I
Q
-
D
---
G
I
Q
D
E
K
Y
Y
Q
N
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
M
C
S
F
N
M
T
-----
P
V
G
I
G
K
--------
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
G
G
G
G
Y
-
N
L
A
N
-
T
A
R
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Fugue
65.98
23%
-35
- C5 -
-
4BZ7
6
?
C:
[2-446]
--------------
S
V
G
I
V
Y
G
D
Q
Y
R
Q
L
C
C
S
----
S
P
K
F
G
D
R
Y
A
L
V
M
D
L
I
N
A
Y
K
L
I
P
E
L
S
-
R
V
P
P
LQW
D
S
P
-----
S
R
M
Y
E
A
V
T
A
F
H
S
T
E
Y
V
D
A
L
K
K
L
Q
M
-----
L
H
C
E---
E
L
---
T
---------
A
D
D
E
L
L
---
M
D
-
S
F
SLNY
D
C
P
G
--
F
P
S
V
F
D
Y
S
L
A
A
V
Q
G
S
L
A
A
A
S
A
L
I
C
----
R
--
H
CE
V
--
V
I
N
W
G
G
G
W
H
H
A
K
R
S
E
A
S
G
F
C
Y
L
N
D
I
V
L
A
I
H
R
L
V
S
S
-----
T
R
V
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
E
A
F
W
Y
S
P
R
V
V
T
F
S
V
--
H
H
A
-
S
P
-------
G
F
F
P
GT
G
T
--
W
N
---
M
---------
K
---------
L
P
I
F
L
N
G
AGRGRFS
A
F
N
L
P
L
E
-
E
---
G
I
N
D
L
D
W
S
N
A
I
G
P
I
L
D
S
L
N
I
V
I
Q
P
S
Y
V
V
V
Q
C
G
A
D
C
L
A
T
D
P
H
R
I
F
R
L
T
-----
N
F
Y
P
S
E
C
S
L
S
G
Y
L
Y
A
I
K
K
I
L
S
W
K
V
P
T
L
I
L
G
G
G
G
Y
N
F
-
P
D
-
T
A
R
L
W
T
R
V
T
A
L
T
I
E
---
E
V
KG
K
K
M
T
I
S
--
P
E
I
P
E
H
S
Y
F
S
R
Y
G
P
D
--
F
E
L
D
I
D
Y
F
P
H
ETLDSI
Q
K
H
H
R
R
I
L
E
Q
L
R
N
Y
A
D
L
N
KLIYD
Y
D
Q
V
Y
Q
L
Y
N
LTGMGSLVPR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.73
26%
-13
- C5 -
-
3EZP
6
HDAC8_HUMAN
A:
[19-314]
------------------
I
Y
S
P
E
Y
V
S
M
C
D
S
L
A
K
I
-----
P
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
H
K
Q
M
R
I
V
-----
K
P
K
-----
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
-
K
V
S
-----
Q
------------------------
D
S
I
EYG
L
G
-
Y
-----
N
C
P
A
--
T
E
G
I
F
D
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
----
G
--
M
--
C
K
V
A
I
N
W
S
G
G
W
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
F
-
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
---
S
P
-------
G
F
F
P
--
G
T
--
G
D
---
V
---------
S
---------
D
V
G
L
G
K
GRYY
S
V
N
----
V
P
I
Q
-
D
---
G
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
M
C
S
F
N
M
T
-----
P
V
G
I
G
K
--------
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
G
G
G
G
Y
-
N
L
A
N
-
T
A
R
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
65.58
23%
-45
- C5 -
-
4BZ7
10
?
A:
[2-368]
--------------
S
V
G
I
V
Y
G
D
Q
Y
R
Q
L
C
----
C
S
S
P
K
F
G
D
R
Y
A
L
V
M
D
L
I
N
A
Y
K
L
I
P
E
L
S
-
R
V
-----
P
P
L
QWDS
P
S
R
M
Y
E
A
V
T
A
F
H
S
T
E
Y
V
D
A
L
K
K
L
Q
M
-----
L
H
-----
C
E
---
E
KELT
A
D
D
E
L
L
M
D
S
F
S
---
L
N
-
Y
-----
D
C
P
G
--
F
P
S
V
F
D
Y
S
L
A
A
V
Q
G
S
L
A
A
A
S
A
L
I
C
----
R
HC
E
--
V
--
V
I
N
W
G
G
G
W
H
H
A
K
R
S
E
A
S
G
F
C
Y
L
N
D
I
V
L
A
I
H
R
L
V
S
S
T
P--
Q
T
R
V
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
E
A
F
W
Y
S
P
R
V
V
T
F
S
V
--
H
---
H
A
S
P-----
G
F
F
P
--
G
T
--
G
T
---
W
---------
N
IFLNGAGRG
R
F
S
A
F
N
-----------
L
P
L
E
-
E
---
G
I
N
D
L
D
W
S
N
A
I
G
P
I
L
D
S
L
N
I
V
I
Q
P
S
Y
V
V
V
Q
C
G
A
D
C
L
A
T
D
P
H
R
I
F
R
L
T
NFYPS
L
S
G
Y
L
Y
A
I
K
----
K
I
L
----
S
W
K
V
P
T
L
I
L
G
G
G
G
Y
-
N
-
F
P
D
T
A
R
L
W
T
R
V
T
A
L
T
I
E
---
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.22
25%
-8
- C5 -
-
1T64
6
HDAC8_HUMAN
A:
[19-314]
------------------
I
Y
S
P
E
Y
V
S
M
C
D
S
L
A
K
I
-----
P
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
H
K
Q
M
R
I
V
-----
K
P
K
-----
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
-
K
V
S
-----
Q
E
-----
G
D
---
D
---------
D
H
P
D
S
I
EYG
L
G
-
Y
-----
D
C
P
A
--
T
E
G
I
F
D
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
----
G
--
M
--
C
K
V
A
I
N
W
S
G
G
W
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
F
-
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
---
S
P
-------
G
F
F
P
--
G
T
--
G
D
---
V
---------
S
---------
D
V
G
L
G
K
GRYY
S
V
N
----
V
P
I
Q
-
D
---
G
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
M
C
S
F
N
M
T
-----
P
V
G
I
G
K
--------
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
G
G
G
G
Y
-
N
L
A
N
-
T
A
R
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Fugue
65.20
26%
-5
- C5 -
-
5G0J
9
?
A:
[17-772]
------
V
Q
G
K
S
K
A
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
-
Q
V
-----
E
A
R
-----
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
MT
E
E
E
L
K
-----
T
L
---
A
---------
E
K
Y
D
S
V
---
Y
L
H
P
-----
G
F
F
S
--
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
------
N
--
G
--
F
--
S
I
N
R
P
P
G
-
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
--
H
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
--
H
R
Y
E
D
G
-------
S
F
W
P
--
H
L
--
K
E
---
S
---------
D
SSSVGSG--
A
G
Q
G
Y
N
-----------
I
N
L
P
-
W
NKV
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
G
G
M
Q
V
S
-----
P
E
C
F
S
I
L
T
H
----
M
L
K
G
V
A
Q
G
R
---
L
V
L
A
L
E
G
G
Y
N
L
-
Q
S
-
T
A
E
G
V
C
A
S
M
R
S
L
L
G
DPC
P
H
-----
L
P
S
--
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
--
I
S
D
L
Y
P
FWKSLQTFEGGPLSEVSP
L
P
A
P
V
C
A
E
VKVSS
P
I
T
G
L
V
Y
D
QRMMLHHNMWDSHHPELPQ
R
I
S
R
I
F
S
R
H
E
E
L
RLLSR
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
CHS
S
K
H
I
S
I
I
K
S
SEHMK
P
R
D
L
N
R
L
G
D
EYNS
I
F
I
S
NE
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
GQVR
N
A
V
A
IVRPPGHHAEKDTACGFCFFN
T
A
A
L
T
A
R
Y
A
Q
S
I
T
RES
L
R
V
L
I
V
D
WDVHHG
N
G
T
Q
H
I
F
EEDDS
V
L
Y
I
S
L
H
RYEDGAFFPNSEDANYDKVGLGKGRGY
N
V
N
IPWNGGKMG
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
APE
L
V
L
V
SAGFDAARGDPLGG
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
MSLAAGR
V
L
I
I
L
E
G
GYN
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
GDSPPSLDHLTPLK
T
S
A
T
V
S
I
N
N
V
L
R
A
H
APFWSSLRVNIPESLRLSL
16
PsiBlast_PDB
65.19
25%
-7
- C5 -
-
4QA1
7
HDAC8_HUMAN
A:
[19-314]
------------------
I
Y
S
P
E
Y
V
S
M
C
D
S
L
A
K
I
P
-----
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
H
K
Q
M
R
I
V
-----
K
P
K
-----
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
-
K
V
S
-----
Q
E
--------------------------EYG
L
G
-
Y
-----
D
C
P
A
--
T
E
G
I
F
D
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
----
G
--
M
--
C
K
V
A
I
N
W
S
G
G
W
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
F
-
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
T
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
---
S
P
-------
G
F
F
P
--
G
T
--
G
D
---
V
---------
S
---------
D
V
G
L
G
K
GRYY
S
V
N
----
V
P
I
Q
-
D
---
G
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
M
C
S
F
N
M
T
-----
P
V
G
I
G
K
--------
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
G
G
G
G
Y
-
N
L
A
N
-
T
A
R
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
65.07
25%
-12
- C5 -
-
1T69
2
HDAC8_HUMAN
A:
[19-314]
------------------
I
Y
S
P
E
Y
V
S
M
C
D
S
L
A
K
I
-----
P
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
H
K
Q
M
R
I
V
-----
K
P
K
-----
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
-
K
V
S
-----
Q
-----------------------
P
D
S
I
EYG
L
G
-
Y
-----
D
C
P
A
--
T
E
G
I
F
D
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
----
G
--
M
--
C
K
V
A
I
N
W
S
G
G
W
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
F
-
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
---
S
P
-------
G
F
F
P
--
G
T
--
G
D
---
V
---------
S
---------
D
V
G
L
G
K
GRYY
S
V
N
----
V
P
I
Q
-
D
---
G
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
M
C
S
F
N
M
T
-----
P
V
G
I
G
K
--------
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
G
G
G
G
Y
-
N
L
A
N
-
T
A
R
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
64.92
23%
-37
- C5 -
-
4A69
8
HDAC3_HUMAN
A:
[2-318]
------------
A
K
T
V
A
Y
F
Y
D
P
D
V
G
N
F
H
Y
G
--
A
G
H
P
M
K
P
H
R
L
A
L
T
H
S
L
V
L
H
Y
G
L
Y
K
K
M
I
-
V
F
-----
K
P
Y
-----
Q
A
S
Q
H
D
M
C
R
F
H
S
E
D
Y
I
D
F
L
Q
R
V
S
P
-----
T
N
-----
M
Q
---
G
F
T
K
------
S
L
N
A
F
N
---
V
G
-
D
-----
D
C
P
V
--
F
P
G
L
F
E
F
C
S
R
Y
T
G
A
S
L
Q
G
A
T
Q
L
N
N
KI--
C
--
D
--
I
--
A
I
N
W
A
G
G
L
H
H
A
K
K
F
E
A
S
G
F
C
Y
V
N
D
I
V
I
G
I
L
E
L
L
K
Y
----
H
P
R
V
L
Y
I
D
I
D
I
H
H
G
D
G
V
Q
E
A
F
Y
L
T
D
R
V
M
T
V
S
F
--
H
---
K
Y
G
N-----
Y
F
F
P
--
G
T
--
G
D
---
M
---------
Y
EVGAESG--
R
Y
Y
C
L
N
-----------
V
P
L
R
-
D
---
G
I
D
D
Q
S
Y
K
H
L
F
Q
P
V
I
N
Q
V
V
D
F
Y
Q
P
T
C
I
V
L
Q
C
G
A
D
S
L
G
C
D
R
L
G
C
F
N
L
S
-----
I
R
G
H
G
E
C
V
E
----
Y
V
K
S
F
----
N
I
P
L
L
V
L
G
G
G
G
Y
-
T
-
V
R
N
V
A
R
C
W
T
Y
E
T
S
L
L
V
E
---
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
64.68
24%
-33
- C5 -
-
4LY1
7
HDAC2_HUMAN
A:
[2-317]
------------
K
K
K
V
C
Y
Y
Y
D
G
D
I
G
N
Y
Y
Y
G
--
Q
G
H
P
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Y
G
L
Y
R
K
M
E
-
I
Y
-----
R
P
H
-----
K
A
T
A
E
E
M
T
K
Y
H
S
D
E
Y
I
K
F
L
R
S
I
R
P
-----
D
N
-----
M
S
EY
S
K
---------
Q
M
Q
R
F
N
---
V
G
-
E
-----
D
C
P
V
--
F
D
G
L
F
E
F
C
Q
L
S
T
G
G
S
V
A
G
A
V
K
L
N
R
QQ--
T
--
D
--
M
--
A
V
N
W
A
G
G
L
H
H
A
K
K
S
E
A
S
G
F
C
Y
V
N
D
I
V
L
A
I
L
E
L
L
K
Y
----
H
Q
R
V
L
Y
I
D
I
D
I
H
H
G
D
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
S
F
--
H
---
K
Y
G
------
E
Y
F
P
--
G
T
--
G
D
---
L
---------
R
DIGAGKG--
K
Y
Y
A
V
N
-----------
F
P
M
R
-
D
---
G
I
D
D
E
S
Y
G
Q
I
F
K
P
I
I
S
K
V
M
E
M
Y
Q
P
S
A
V
V
L
Q
C
G
A
D
S
L
S
G
D
R
L
G
C
F
N
L
T
-----
V
K
G
H
A
K
C
V
E
----
V
V
K
T
F
----
N
L
P
L
L
M
L
G
G
G
G
Y
-
T
-
I
R
N
V
A
R
C
W
T
Y
E
T
A
V
A
L
D
---
C
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
64.62
22%
-48
- C5 -
-
5EDU
4
HDAC6_HUMAN (first)
B:
[382-715]
------
A
Q
T
N
A
A
A
S
R
T
G
L
V
Y
D
Q
N
M
M
N
H
C
N
L
W
D
S
H
H
P
E
V
P
Q
R
I
L
R
I
M
C
R
L
E
E
L
G
L
A
G
R
C
L
-
T
L
-----
T
P
R
-----
P
A
T
E
A
E
L
L
T
C
H
S
A
E
Y
V
G
H
L
R
A
T
E
K
-----
M
K
-----
T
R
---
E
---------
L
H
R
E
S
S
---
N
F
-
D
-----
S
I
Y
I
--
C
P
S
T
F
A
C
A
Q
L
A
T
G
A
A
C
R
L
V
E
A
V
L
S
GEVL
N
--
G
--
A
--
A
V
V
R
P
P
G
-
H
H
A
E
Q
D
A
A
C
G
F
C
F
F
N
S
V
A
V
A
A
R
H
A
Q
T
I
S
-
G
H
A
L
R
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
M
F
E
D
D
P
S
V
L
Y
V
S
L
--
H
---
R
Y
DHG----
T
F
F
P
--
M
G
DE
G
A
---
S
SQIGRAA--
G
---------
T
G
F
T
V
N
-----------
V
A
W
N
G
P
---
R
M
G
D
A
D
Y
L
A
A
W
H
R
L
V
L
P
I
A
Y
E
F
N
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
G
G
C
Q
V
S
-----
P
E
G
Y
A
H
L
T
H
----
L
L
M
G
L
A
---
S
G
R
I
I
L
I
L
E
G
G
Y
-
N
-
L
T
S
I
S
E
S
M
A
A
C
T
R
S
L
L
G
---
D
P
-----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
64.45
25%
-11
- C5 -
-
3EW8
5
HDAC8_HUMAN
A:
[19-314]
------------------
I
Y
S
P
E
Y
V
S
M
C
D
S
L
A
K
I
-----
P
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
H
K
Q
M
R
I
V
-----
K
P
K
-----
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
S
Q
-----
E
G
-------------------------
E
---
Y
G
-
L
-----
G
Y
L
C
PA
T
E
G
I
F
D
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
----
G
--
M
--
C
K
V
A
I
N
W
S
G
G
W
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
F
-
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
---
S
P
-------
G
F
F
P
--
G
T
--
G
D
---
V
---------
S
---------
D
V
G
L
G
K
GRYY
S
V
N
----
V
P
I
Q
-
D
---
G
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
M
C
S
F
N
M
T
-----
P
V
G
I
G
K
--------
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
G
G
G
G
Y
-
N
L
A
N
-
T
A
R
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.30
25%
-12
- C5 -
-
3MZ4
5
HDAC8_HUMAN
A:
[19-314]
------------------
I
Y
S
P
E
Y
V
S
M
C
D
S
L
A
K
I
P
-----
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
H
K
Q
M
R
I
V
-----
K
P
K
-----
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
S
Q
--------------------------------
E
---
Y
G
-
L
-----
G
Y
L
C
PA
T
E
G
I
F
D
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
----
G
--
M
--
C
K
V
A
I
N
W
S
G
G
W
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
F
-
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
---
S
P
-------
G
F
F
P
--
G
T
--
G
D
---
V
---------
S
---------
D
V
G
L
G
K
GRYY
S
V
N
----
V
P
I
Q
-
D
---
G
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
M
C
S
F
N
M
T
-----
P
V
G
I
G
K
--------
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
G
G
G
G
Y
-
N
L
A
N
-
T
A
R
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------