@TOME V2.3
(Mar 2018)

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Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : HDA11_HUMAN: (2017-06-15 )
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP

Atome Classification :

(20 SA) .........10........20........30........40........50........-60-----...-----.....70........80.......-----.90----..---.---------......---100.-----....--...110.......120.......130--.--.--.--......140.......150.......160.......-170.......180.......190.......200.--.---..-------...210..--..---.---------.---------...220-----------....-.---..230.......240.......250.......260.......270..-----.....280.----......290.......300..-.-..-..310.......320--..-----...--...330.......340-......---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome) (Ident) (Tito) (Num) (QMean) (Ligand) (Uniprot) MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSM-LV-----EAR-----EASEEDLLVVHTRRYLNELKWSFA-----VA-----TI---T---------EIPPVI---FL-P-----NFLV--QRKVLRPLRTQTGGTIMAGKLAVE----R--G--W--AINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERV-EGISRATIIDLDAHQGNGHERDFMDDKRVYIMDV--Y---NR-------HIYP--GD--RF---A---------K---------QAIRRK-----------VELE-W---GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSIS-----PAGIVKRDE----LVFRMVRGRRVPILMVTSGGY-Q-KR-TARIIADSILNLFG---LG-----LIG--PESPSVSAQNSDTPL--LPPAVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78 Fugue 70.6226% -39 - C5 - - 4QA5 HDAC8_HUMAN A:[14-377] ---------LVP----VYIYSPEYVSMCDSLAKI----PKRASMVHSLIEAYALHKQMR-IV-----KPK-----VASMEEMATFHTDAYLQHLQKVSQ-----EG-----DD---D---------HPDSIE---YG-L-----GYDCPATEGIFDYAAAIGGATITAAQCLID----GMCK--V--AINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKF-E---RILYVDLDLHHGDGVEDTFSFTSKVMTVSL--HKF-SP-------GFFP--GT--GD---V---------S---------DVGLGKGRYYSVN----VPIQ-D---GIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMT-----PVGIGKCLK----YILQW----QLATLILGGGGFNL-AN-TARCWTYLTGVILG---KT-----LSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52 HHSearch 68.1723% -39 - C5 - - 5DC8 HDAC8_HUMAN A:[14-326] -------------LVPVYIYSPEYVSMC----DSLAKIPKRASMVHSLIEAYALHKQMR-IV-----KPK-----VASMEEMATFHTDAYLQHLQKVSQ-----EG-----DD---DHP-------DSIEYG---LG-Y-----DCPA--TEGIFDYAAAIGGATITAAQCLIDGM--C--K--V--AINWSGGWAHAKKDEASGFCYLNDAVLGILRLRRK----FERILYVDLDLHHGDGVEDAFSFTSKVMTVSL--H---KFSP-----GFFP--GT--GD---V---------SDVGLGKG--RYYSVN-----------VPIQ-D---GIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMT-----PVGIGKCLK----YILQW----QLATLILGGGGF-N-LANTARCWTYLTGVILG---KT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1 PsiBlast_PDB 67.0126% 13 - C5 - - 5G0J ? A:[45-355] ----------------------------------HPECPARVSTVMEMLETEGLLGRCV-QV-----EAR-----AVTEDELLLVHTKEYVELMKSTQN-----MTEEELKTL---A---------EKYDSV---YLHP-----GFFS--SACLSVGSVLQLVDKVMTSQL--R----N--G--F--SINRPPG-HHAQADKMNGFCMFNNLAIAARYAQKR--HRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSV--H---RYEDGSFWPHLKE--SD--SSSVGS---------G---------AGQGYN-----------INLP-WNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVS-----PECFSILTH----MLKGVAQGR---LVLALEGGY-NLQS-TAEGVCASMRSL-----LG-----DPC--PHLPSSGA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2 PsiBlast_PDB 66.3726% 10 - C5 - - 5G0I ? A:[60-392] ----------------------------------HPECPARVSTVMEMLETEGLLGRCV-QV-----EAR-----AVTEDELLLVHTKEYVELMKSTQN-----MTEEELKTL---A---------EKYDSV---YLHP-----GFFS--SACLSVGSVLQLVDKVMTSQL--R----N--G--F--SINRPPG-HHAQADKMNGFCMFNNLAIAARYAQKR--HRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSV--H---RYEDGSFWPHLKE--SD--SSSVGS---------G---------AGQGYN-----------INLP-WNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVS-----PECFSILTH----MLKGVAQGR---LVLALEGGY-NLQS-TAEGVCASMRSL-----LG-----DPC--PHLPSSGA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3 PsiBlast_PDB 66.3226% 11 - C5 - - 5EEF ? A:[29-339] ----------------------------------HPECPARVSTVMEMLETEGLLGRCV-QV-----EAR-----AVTEDELLLVHTKEYVELMKSTQN-----MTEEELKTL---A---------EKYDSV---YLHP-----GFFS--SACLSVGSVLQLVDKVMTSQL--R----N--G--F--SINRPPG-HHAQADKMNGFCMFNNLAIAARYAQKR--HRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSV--H---RYEDGSFWPHLKE--SD--SSSVGS---------G---------AGQGYN-----------INLP-WNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVS-----PECFSILTH----MLKGVAQGR---LVLALEGGY-NLQS-TAEGVCASMRSL-----LG-----DPC--PHLPSSGA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4 PsiBlast_PDB 66.2526% 8 - C5 - - 5G0G ? A:[44-354] ----------------------------------HPECPARVSTVMEMLETEGLLGRCV-QV-----EAR-----AVTEDELLLVHTKEYVELMKSTQN-----MTEEELKTL---A---------EKYDSV---YLHP-----GFFS--SACLSVGSVLQLVDKVMTSQL--R----N--G--F--SINRPPG-HHAQADKMNGFCMFNNLAIAARYAQKR--HRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSV--H---RYEDGSFWPHLKE--SD--SSSVGS---------G---------AGQGYN-----------INLP-WNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVS-----PECFSILTH----MLKGVAQGR---LVLALEGGY-NLQS-TAEGVCASMRSL-----LG-----DPC--PHLPSSGA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51 HHSearch 66.0523% -41 - C5 - - 5G0G ? A:[21-346] -----------KATGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCV-QV-----EAR-----AVTEDELLLVHTKEYVELMKSTQN-----MT-----EE---E---------LKTLAE---KY-D-----SVYL--HPGFFSSACLSVGSVLQLVDKVMTSQLRN--G--F--SINRPPG-HHAQADKMNGFCMFNNLAIAARYAQKRH--RVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSV--H---RYEDG----SFWP--HL--KE---SDSSSVGSGAG---------QGYNIN-----------LPWNKV---GMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVS-----PECFSILTH----MLKGVA---QGRLVLALEGGY-N-LQSTAEGVCASMRSLLG---DP-----C------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14 PsiBlast_PDB 66.0025% -6 - C5 - - 4QA2 HDAC8_HUMAN A:[19-314] ------------------IYSPEYVSMCDSLAKIP-----KRASMVHSLIEAYALHKQMRIV-----KPK-----VASMEEMATFHTDAYLQHLQ-KVS-----QE-----G--------------------YG-LG-Y-----DCPA--TEGIFDYAAAIGGATITAAQCLID----G--M--CKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKF-E---RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKF---SP-------GFFP--GT--GD---V---------S---------DVGLGKGRYYSVN----VPIQ-D---GIQDEKYYQNCESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMT-----PVGIGK--------CLKYILQWQLATLILGGGGY-NLAN-TARC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77 Fugue 65.9823% -35 - C5 - - 4BZ7 ? C:[2-446] --------------SVGIVYGDQYRQLCCS----SPKFGDRYALVMDLINAYKLIPELS-RVPPLQWDSP-----SRMYEAVTAFHSTEYVDALKKLQM-----LHCE---EL---T---------ADDELL---MD-SFSLNYDCPG--FPSVFDYSLAAVQGSLAAASALIC----R--HCEV--VINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSS-----TRVLYVDLDLHHGDGVEEAFWYSPRVVTFSV--HHA-SP-------GFFPGTGT--WN---M---------K---------LPIFLNGAGRGRFSAFNLPLE-E---GINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLT-----NFYPSECSLSGYLYAIKKILSWKVPTLILGGGGYNF-PD-TARLWTRVTALTIE---EVKGKKMTIS--PEIPEHSYFSRYGPD--FELDIDYFPHETLDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQLYNLTGMGSLVPR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13 PsiBlast_PDB 65.7326% -13 - C5 - - 3EZP HDAC8_HUMAN A:[19-314] ------------------IYSPEYVSMCDSLAKI-----PKRASMVHSLIEAYALHKQMRIV-----KPK-----VASMEEMATFHTDAYLQHLQ-KVS-----Q------------------------DSIEYGLG-Y-----NCPA--TEGIFDYAAAIGGATITAAQCLID----G--M--CKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKF-E---RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKF---SP-------GFFP--GT--GD---V---------S---------DVGLGKGRYYSVN----VPIQ-D---GIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMT-----PVGIGK--------CLKYILQWQLATLILGGGGY-NLAN-TARC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58 HHSearch 65.5823% -45 - C5 - - 4BZ7 ? A:[2-368] --------------SVGIVYGDQYRQLC----CSSPKFGDRYALVMDLINAYKLIPELS-RV-----PPLQWDSPSRMYEAVTAFHSTEYVDALKKLQM-----LH-----CE---EKELTADDELLMDSFS---LN-Y-----DCPG--FPSVFDYSLAAVQGSLAAASALIC----RHCE--V--VINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSSTP--QTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSV--H---HASP-----GFFP--GT--GT---W---------NIFLNGAGRGRFSAFN-----------LPLE-E---GINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPSLSGYLYAIK----KIL----SWKVPTLILGGGGY-N-FPDTARLWTRVTALTIE---E-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18 PsiBlast_PDB 65.2225% -8 - C5 - - 1T64 HDAC8_HUMAN A:[19-314] ------------------IYSPEYVSMCDSLAKI-----PKRASMVHSLIEAYALHKQMRIV-----KPK-----VASMEEMATFHTDAYLQHLQ-KVS-----QE-----GD---D---------DHPDSIEYGLG-Y-----DCPA--TEGIFDYAAAIGGATITAAQCLID----G--M--CKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKF-E---RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKF---SP-------GFFP--GT--GD---V---------S---------DVGLGKGRYYSVN----VPIQ-D---GIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMT-----PVGIGK--------CLKYILQWQLATLILGGGGY-NLAN-TARC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79 Fugue 65.2026% -5 - C5 - - 5G0J ? A:[17-772] ------VQGKSKATGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCV-QV-----EAR-----AVTEDELLLVHTKEYVELMKSTQNMTEEELK-----TL---A---------EKYDSV---YLHP-----GFFS--SACLSVGSVLQLVDKVMTSQLR------N--G--F--SINRPPG-HHAQADKMNGFCMFNNLAIAARYAQKR--HRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSV--HRYEDG-------SFWP--HL--KE---S---------DSSSVGSG--AGQGYN-----------INLP-WNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVS-----PECFSILTH----MLKGVAQGR---LVLALEGGYNL-QS-TAEGVCASMRSLLGDPCPH-----LPS--SGAPCESALKSISKT--ISDLYPFWKSLQTFEGGPLSEVSPLPAPVCAEVKVSSPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLRVNIPESLRLSL
16 PsiBlast_PDB 65.1925% -7 - C5 - - 4QA1 HDAC8_HUMAN A:[19-314] ------------------IYSPEYVSMCDSLAKIP-----KRASMVHSLIEAYALHKQMRIV-----KPK-----VASMEEMATFHTDAYLQHLQ-KVS-----QE--------------------------EYGLG-Y-----DCPA--TEGIFDYAAAIGGATITAAQCLID----G--M--CKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKF-E---RILYVDLDLHHGDGVEDTFSFTSKVMTVSLHKF---SP-------GFFP--GT--GD---V---------S---------DVGLGKGRYYSVN----VPIQ-D---GIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMT-----PVGIGK--------CLKYILQWQLATLILGGGGY-NLAN-TARC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------