@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HDAC4_HUMAN: (2017-06-15 )
MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL
Atome Classification :
(61 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130...-....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650--........660.......670.......680.......690.......700.......710.......720........730.......740.......750...-....760.......770.......780.......790.......800.......810.......820......-.830-.......840.......850.......860.......870..--..--.--.--.880.......890...-....900....----...910.......920.......930.......940.......950......-.960---..----......970.......980.......990.......1000......-1010......1020......1030......1040......1050......1060......1070......1080.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSSQSHPDGLSGRDQ
P
V
E
LLN
P
A
RVNHMPSTV
D
V
ATALPLQVAPSAV
P
M
D
L
R
LDHQFSLPVA
E
P
A
L
R
E
Q
Q
L
Q
Q
E
L
L
A
L
K
Q
K
Q
Q
I
Q
R
Q
I
L
I
A
E
F
Q
R
Q
H
E
Q
L
S
R
Q
H
E
A
Q
L
H
E
H
I
K
Q
Q
Q
E
M
L
A
M
K
H
Q
Q
E
L
L
E
H
Q
R
K
L
E
-
R
H
R
Q
E
Q
E
L
E
K
Q
H
R
E
Q
K
L
Q
Q
L
K
N
K
EKGKESAVA
S
T
E
V
K
M
K
L
Q
E
F
V
L
N
K
K
K
A
L
A
HR
N
L
N
H
CISSDP
R
Y
W
YGKTQHSSLDQSSPPQSGVSTSYNHP
V
L
G
M
YDAKDDFPLRKTASEP
N
L
K
L
R
S
R
L
K
Q
K
V
A
E
R
RSSPLLRRKDG
P
V
V
T
A
L
KKRPLDVTD
S
A
CSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIP
A
E
T
S
L
A
H
R
L
V
AREGSAAPLPLYTSPSLP
N
I
T
L
GLPATGPSAGTAGQ
Q
D
A
E
RL
T
L
P
A
L
Q
Q
R
L
S
LFPGTHLTPYLSTSPLERDGGA
A
H
S
P
L
L
Q
H
M
V
L
LEQPPAQAP
L
V
TGLGALP
L
H
A
Q
S
LV
G
A
DRV
S
P
S
I
H
K
L
R
QHRPLGRTQSAPLP
Q
N
A
Q
A
L
Q
H
L
V
I
Q
Q
Q
H
Q
Q
F
L
E
K
H
K
Q
Q
F
Q
Q
Q
Q
L
Q
M
N
KIIPKPSEPARQPESH
P
E
E
T
E
E
E
L
R
E
H
Q
A
L
LDE
P
Y
L
D
RLPGQ
K
E
A
H
A
QAG
V
Q
V
KQEPIESDEEEAEPPREVEPGQRQP
S
E
Q
E
L
L
F
R
Q
Q
A
L
L
L
E
Q
Q
R
I
H
Q
L
R
N
Y
Q
A
SMEAAG
I
P
VSFGGHRPL
S
R
AQSSPAS
A
T
F
P
V
SVQEPPTKPR---F
T
T
G
L
V
Y
D
T
L
M
L
K
H
QCTCGSSSSH
P
E
HA
G
R
I
Q
S
I
W
S
R
L
Q
ETGLRG
K
C
E
CIRG
R
K
A
T
L
E
E
L
Q
T
V
H
SEA
H
T
-
L
L
YGTNPL
N
R
QKL
D
S
K
K
L
L
G
S
L
A
S
V
F
VRLPCGGVG-VD
S
D
T
I
W
N
E
V
H
SA
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
VATGELKN
G
F
A
VVRPPGHHAEEST
P
M
G
F
C
YF
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-LSV
S
-
K
I
L
I
V
D
W
D
VHHGNGTQQAFYSDP
S
V
L
Y
M
S
L
H
RYDDGNFFPGS--GA--P--D--EVGTGPGV
G
F
N
V
N
M
A
F
T-GGLDPPMG
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
EFAP
D
V
V
L
VSSGFDAVEGHPTPLGGYN
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----GL----AG
G
R
I
V
L
A
L
EGGHD
L
T
A
IC
D
A
S
E
A
C
V
S
A
L
LGNELDP
L
P
E
K
V
L
Q
QRP-N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
TAG
R
S
L
I
E
A
QTCENEEA
E
T
V
T
A
M
A
S
L
SVGVKPAEKRPDEEPMEEEPPL
1
PsiBlast_PDB
84.62
100%
-111
- C4 -
-
2VQJ
9
A:
[6-407]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
---
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
V
F
V
R
L
P
C
G
G
V
G
-
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
N
E
---------------------------------
2
PsiBlast_PDB
83.45
100%
-114
- C4 -
-
2VQM
5
A:
[6-407]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
---
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
-------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
N
R
Q
----
K
K
L
L
G
S
L
A
S
V
F
V
R
L
P
C
G
G
V
G
-
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
N
E
---------------------------------
29
PsiBlast_CBE
83.03
99%
-115
- C4 -
-
4CBY
6
HDAC4_HUMAN
B:
[8-387]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
V
F
V
R
L
P
C
G
G
V
G
-
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
-----------------------------------------------------
6
PsiBlast_PDB
82.29
99%
-115
- C4 -
-
4CBY
5
HDAC4_HUMAN
A:
[9-388]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
V
F
V
R
L
P
C
G
G
V
G
-
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
----------------------------------------------------
27
PsiBlast_CBE
81.98
99%
-119
- C4 -
-
4CBY
5
D:
[9-389]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
V
F
V
R
L
P
C
G
G
V
G
-
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
---------------------------------------------------
28
PsiBlast_CBE
81.52
99%
-117
- C4 -
-
4CBY
5
HDAC4_HUMAN
C:
[9-388]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
V
F
V
R
L
P
C
G
G
V
G
-
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
----------------------------------------------------
26
PsiBlast_CBE
81.37
99%
-115
- C4 -
-
5A2S
4
B:
[9-388]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
V
F
V
R
L
P
C
G
G
V
G
-
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
----------------------------------------------------
3
PsiBlast_PDB
80.98
99%
-107
- C4 -
-
2VQQ
7
HDAC4_HUMAN
A:
[7-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
-----------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
----------------------------
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
-----------------------------------
7
PsiBlast_PDB
80.78
99%
-112
- C4 -
-
5A2S
4
HDAC4_HUMAN
A:
[9-388]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
V
F
V
R
L
P
C
G
G
V
G
-
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
----------------------------------------------------
4
PsiBlast_PDB
80.73
99%
-111
- C4 -
-
2VQO
7
HDAC4_HUMAN
A:
[7-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
----------------------------
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
-----------------------------------
23
PsiBlast_CBE
80.69
99%
-111
- C4 -
-
2VQO
6
B:
[7-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
F
T
T
G
L
V
Y
D
T
L
M
L
K
-------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
-----------------------------
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
-----------------------------------
21
PsiBlast_CBE
80.44
99%
-109
- C4 -
-
2VQQ
6
B:
[7-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
--------------
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
-----------------------------
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
-----------------------------------
22
PsiBlast_CBE
79.88
99%
-114
- C4 -
-
2VQV
8
B:
[7-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
F
T
T
G
L
V
Y
D
T
L
M
L
K
-------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
-------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
-----------------------------------
5
PsiBlast_PDB
78.98
99%
-113
- C4 -
-
2VQV
6
HDAC4_HUMAN
A:
[7-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
F
T
T
G
L
V
Y
D
T
L
M
L
K
--------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
--------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
-----------------------------------
25
PsiBlast_CBE
78.19
100%
-110
- C4 -
-
4CBT
3
HDAC4_HUMAN
B:
[5-388]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
R
---
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
-------------------------------
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
--
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
----------------------------------------------------
24
PsiBlast_CBE
76.80
100%
-114
- C4 -
-
4CBT
3
C:
[4-389]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
P
R
---
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
----
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
--------------------------------
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
--
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
-
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
------
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
---------------------------------------------------
31
PsiBlast_CBE
76.76
71%
-112
- C4 -
-
3ZNS
5
HDAC7_HUMAN
B:
[38-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
--
V
M
L
P
C
G
G
V
G
-
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
-
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
---------------------------------------------------
30
PsiBlast_CBE
74.63
71%
-115
- C4 -
-
3ZNS
5
C:
[39-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
---------------------
L
P
C
G
G
V
G
-
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
-
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
----------------------------------------------------
32
PsiBlast_CBE
74.30
71%
-112
- C4 -
-
3ZNR
4
C:
[39-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
---------------------
L
P
C
G
G
V
G
-
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
-
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
----------------------------------------------------
36
PsiBlast_CBE
73.91
71%
-111
- C4 -
-
3C0Z
5
C:
[39-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
---------------------
L
P
C
G
G
V
G
-
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
-
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
----------------------------------------------------
34
PsiBlast_CBE
73.36
71%
-114
- C4 -
-
3C10
5
C:
[39-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
---------------------
L
P
C
G
G
V
G
-
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
-
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
----------------------------------------------------
10
PsiBlast_PDB
71.06
71%
-10
- C4 -
-
3C10
5
HDAC7_HUMAN
A:
[35-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLP
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
--
V
M
L
P
C
G
G
V
G
-
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
-
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
---------------------------------------------------
9
PsiBlast_PDB
69.37
71%
-10
- C4 -
-
3C0Z
5
HDAC7_HUMAN
A:
[35-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLP
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
--
V
M
L
P
C
G
G
V
G
-
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
-
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
---------------------------------------------------
11
PsiBlast_PDB
68.40
71%
3
- C4 -
-
3ZNR
5
HDAC7_HUMAN
A:
[36-421]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LP-
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
-----------------
V
M
L
P
C
G
G
V
G
-
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
-
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
--------------------------------------------------
12
PsiBlast_PDB
68.25
71%
1
- C4 -
-
3ZNS
5
HDAC7_HUMAN
A:
[36-421]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LP-
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
-----------------
V
M
L
P
C
G
G
V
G
-
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
-
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
--------------------------------------------------
37
PsiBlast_CBE
67.43
71%
-1
- C4 -
-
3C0Z
5
HDAC7_HUMAN
B:
[36-421]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LP-
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
-----------------
V
M
L
P
C
G
G
V
G
-
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
-
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
--------------------------------------------------
35
PsiBlast_CBE
66.77
71%
-3
- C4 -
-
3C10
5
HDAC7_HUMAN
B:
[36-421]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LP-
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
-----------------
V
M
L
P
C
G
G
V
G
-
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
-
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
--------------------------------------------------
153
HHSearch
63.91
40%
-74
- C4 -
-
5G0G
9
?
A:
[22-380]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
--
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
-
E
L
M
K
S
T
Q
N
M
T
E
----
E
E
L
-----
K
T
L
----
A
---
E
-
K
Y
D
S
V
Y
L
H
-
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
--
K
E
SD
S
--
S
--
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
V
G
----
M
E
S
G
D
----
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
--
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
-
M
L
K
----
G
V
----
A
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
P
C
P
H
L
P
S
S
---
G
A
P
-
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
F
--------------------------------------------------
14
PsiBlast_PDB
62.45
41%
-57
- C4 -
-
5G0J
5
?
A:
[385-761]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
E
V
S
P
L
P
A
P
V
C
A
E
V
K
V
S
S
P
---------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
20
PsiBlast_PDB
61.93
42%
-61
- C4 -
-
5EF7
4
?
A:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
47
PsiBlast_CBE
61.77
42%
-60
- C4 -
-
5EF8
7
?
B:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
48
PsiBlast_CBE
61.52
42%
-61
- C4 -
-
5EF8
6
?
A:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
18
PsiBlast_PDB
61.42
42%
-62
- C4 -
-
5EEM
5
?
B:
[10-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
-----------------------------------------------------
152
HHSearch
61.11
45%
-51
- C4 -
-
5G0H
14
?
A:
[404-763]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
----
P
R
D
L
-------------
N
R
L
G
-
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
--
E
D
AN
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
---
T
P
L
-
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
V
N
--------------------------------------------------
55
PsiBlast_CBE
61.07
42%
-61
- C4 -
-
5EFN
5
?
A:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
17
PsiBlast_PDB
61.03
42%
-61
- C4 -
-
5EEK
30
?
A:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
--
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
49
PsiBlast_CBE
61.02
42%
-61
- C4 -
-
5EF7
5
?
B:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
D
--
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
43
PsiBlast_CBE
60.98
42%
-61
- C4 -
-
5EFH
9
?
A:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
19
PsiBlast_PDB
60.87
42%
-63
- C4 -
-
5EEN
4
?
B:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
----
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
53
PsiBlast_CBE
60.76
42%
-58
- C4 -
-
5EFK
8
?
B:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
F
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
-
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
50
PsiBlast_CBE
60.72
42%
-59
- C4 -
-
5EEN
5
?
A:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
54
PsiBlast_CBE
60.61
42%
-62
- C4 -
-
5EFN
6
?
B:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
42
PsiBlast_CBE
60.51
42%
-59
- C4 -
-
5EFH
7
?
D:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
-
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
13
PsiBlast_PDB
60.48
41%
-61
- C4 -
-
5G0H
14
?
A:
[404-761]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
---------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
46
PsiBlast_CBE
60.27
42%
-59
- C4 -
-
5EFB
4
?
D:
[10-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
---------------
N
E
S
Y
T
C
--
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
----
P
P
S
L
--
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
----------------------------------------------------
58
PsiBlast_CBE
59.14
38%
-45
- C4 -
-
5EEF
7
?
A:
[10-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
V
D
A
F
T
R
F
H
-------
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
------
L
A
E
K
Y
-------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
--
K
E
--
S
--
D
SS
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
----
K
V
G
M
E
S
G
D
----
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
-
M
L
K
----
G
V
----
A
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
S
G
A
P
-
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
----------------------------------------------------
56
PsiBlast_CBE
58.21
38%
-43
* C4 *
-
5G0G
9
?
A:
[25-378]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
--
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
------
L
A
E
K
Y
-------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
--
K
E
--
S
--
D
SS
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
----
K
V
G
M
E
S
G
D
----
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
-
M
L
K
----
G
V
----
A
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
S
G
A
P
-
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
----------------------------------------------------
57
PsiBlast_CBE
58.07
38%
-44
- C4 -
-
5EEF
6
?
B:
[10-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
--
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
------
L
A
E
K
Y
-------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
--
K
E
--
S
--
D
SS
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
----
K
V
G
M
E
S
G
D
----
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
-
M
L
K
----
G
V
----
A
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
S
G
A
P
-
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
----------------------------------------------------
171
Fugue
57.80
33%
-7
- C4 -
-
5G0J
9
?
A:
[17-772]
V
Q
G
K
S
K
A
T
G
-------
T
G
L
V
Y
--------------------------------------------------------------------
V
D
A
F
T
R
F
H
C
L
W
D
A
S
H
P
----
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
---------
E
E
E
L
K
T
L
A
E
K
Y
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
---
T
S
Q
L
R
N
G
F
S
--
I
N
R
P
P
-
G
H
H
A
Q
A
D
--
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
R
V
Q
R
V
L
I
V
D
--------------
W
D
V
H
H
G
-----------------------
Q
G
I
Q
Y
I
F
E
E
D
P
---
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
------------
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
--
N
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
---------------
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
---
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
Q
G
-----------
R
L
V
L
A
L
E
-----------------------------------------------------------
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
------
P
C
P
H
L
P
S
S
G
A
P
C
-------
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
------
F
E
G
G
-
P
L
S
E
V
S
P
L
P
A
P
V
C
A
E
V
K
V
S
S
P
I
---------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
--
W
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
-
H
M
K
P
R
D
L
N
R
L
G
D
E
Y
N
S
I
F
---------------
I
S
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
--
E
D
--
A
NY
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
-
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
--
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
---
L
T
P
L
-
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------
V
N
I
P
E
S
L
R
L
S
L
------------------
161
HHSearch
51.85
34%
-111
- C4 -
-
5JI5
6
?
A:
[10-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
G
F
Y
S
H
A
D
C
L
Q
H
E
M
G
----
Q
W
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
L
A
D
E
A
A
L
L
R
V
H
T
K
A
H
V
-
D
Y
L
R
A
R
S
P
Q
S
---------------------
G
Y
A
E
-
I
D
P
D
T
S
M
N
P
-
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
V
-
H
K
L
E
-
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
---
P
F
Y
P
F
T
--
G
A
--
D
--
N
--------
Q
A
P
N
M
C
N
V
P
I
A
-
A
R
----
S
K
G
M
V
----
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
E
D
--
D
L
G
N
M
A
L
V
E
D
D
Y
A
W
I
T
Q
-
Q
I
R
----
L
V
A
D
K
Y
A
K
G
R
I
V
S
C
L
E
G
G
Y
N
L
S
A
L
G
R
S
V
V
A
H
V
R
A
L
A
D
-------------------------------------------------------------------------------------------
79
PsiBlast_CBE
43.00
31%
-51
- C4 -
-
5JI5
6
?
A:
[28-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
L
A
D
E
A
A
L
L
R
V
H
T
K
A
H
-----------------------
V
D
Y
L
R
A
R
S
P
Q
S
G
Y
A
E
I
D
P
D
T
S
M
N
P
-
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
V
-
H
K
L
E
-
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
P
---
F
Y
P
F
T
--
G
A
--
D
--
N
--
Q
---
A
P
N
M
C
N
V
P
I
A
A
R
S
-
K
G
M
-------
V
----
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
--
H
R
E
D
D
L
G
N
M
A
L
V
E
D
D
Y
A
W
I
T
Q
-
Q
I
R
L
V
A
D
K
Y
----
A
K
G
R
I
V
S
C
L
E
G
G
Y
N
L
S
A
L
G
R
S
V
V
A
H
V
R
A
L
---------------------------------------------------------------------------------------------
92
PsiBlast_CBE
35.79
33%
-47
- C4 -
-
4ZUP
8
APHA_MYCRA
A:
[142-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
---------
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
D
P
I
S
F
--
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
----
A
A
----
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
--------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
35.78
33%
-47
- C4 -
-
4ZUQ
6
APHA_MYCRA
B:
[142-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
---------
P
M
G
R
G
T
PYSV
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
D
P
I
S
F
--
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
----
A
A
----
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
--------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
35.61
33%
-46
- C4 -
-
4ZUN
4
APHA_MYCRA
B:
[142-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
---------
P
M
G
R
G
T
PYSV
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
D
P
I
S
F
--
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
----
A
A
----
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
--------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
35.50
33%
-47
- C4 -
-
4ZUP
6
APHA_MYCRA
B:
[142-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
---------
P
M
G
R
G
T
PYSV
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
D
P
I
S
F
--
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
----
A
A
----
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
--------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
35.48
33%
-45
- C4 -
-
4ZUN
5
APHA_MYCRA
A:
[142-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
---------
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
D
P
I
S
F
--
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
----
A
A
----
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
--------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
35.33
33%
-47
- C4 -
-
4ZUM
5
APHA_MYCRA
B:
[142-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
---------
P
M
G
R
G
T
PYSV
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
D
P
I
S
F
--
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
----
A
A
----
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
--------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
35.24
33%
-46
- C4 -
-
4ZUO
6
APHA_MYCRA
B:
[142-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
---------
P
M
G
R
G
T
PYSV
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
D
P
I
S
F
--
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
----
A
A
----
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
--------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
35.15
33%
-46
- C4 -
-
4ZUO
5
APHA_MYCRA
A:
[142-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
---------
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
D
P
I
S
F
--
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
----
A
A
----
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
--------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
35.11
33%
-47
- C4 -
-
4ZUM
6
APHA_MYCRA
A:
[142-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
---------
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
D
P
I
S
F
--
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
----
A
A
----
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
--------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
33.69
33%
-47
- C4 -
-
4ZUQ
6
APHA_MYCRA
A:
[142-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
---------
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
D
P
I
S
F
--
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
----
A
A
----
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
--------------------------------------------------------------------------------------------------------