@TOME V2.3
(Mar 2018)

Ref. - - Doc.
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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : HDAC4_HUMAN: (2017-06-15 )
MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL

Atome Classification :

(61 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130...-....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650--........660.......670.......680.......690.......700.......710.......720........730.......740.......750...-....760.......770.......780.......790.......800.......810.......820......-.830-.......840.......850.......860.......870..--..--.--.--.880.......890...-....900....----...910.......920.......930.......940.......950......-.960---..----......970.......980.......990.......1000......-1010......1020......1030......1040......1050......1060......1070......1080.
(Atome) (Ident) (Tito) (Num) (QMean) (Ligand) (Uniprot) MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLE-RHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPR---FTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL
1 PsiBlast_PDB 84.62100%-111 - C4 - - 2VQJ A:[6-407] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PR---FTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENE---------------------------------
2 PsiBlast_PDB 83.45100%-114 - C4 - - 2VQM A:[6-407] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PR---FTTGLVYDTLMLKHQCTCG-------HAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPLNRQ----KKLLGSLASVFVRLPCGGVG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENE---------------------------------
29 PsiBlast_CBE 83.0399%-115 - C4 - - 4CBY HDAC4_HUMAN B:[8-387] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPANRQKLDSKKLLGSLASVFVRLPCGGVG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCL-----------------------------------------------------
6 PsiBlast_PDB 82.2999%-115 - C4 - - 4CBY HDAC4_HUMAN A:[9-388] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPANRQKLDSKKLLGSLASVFVRLPCGGVG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQ----------------------------------------------------
27 PsiBlast_CBE 81.9899%-119 - C4 - - 4CBY D:[9-389] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPANRQKLDSKKLLGSLASVFVRLPCGGVG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQR---------------------------------------------------
28 PsiBlast_CBE 81.5299%-117 - C4 - - 4CBY HDAC4_HUMAN C:[9-388] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPANRQKLDSKKLLGSLASVFVRLPCGGVG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQ----------------------------------------------------
26 PsiBlast_CBE 81.3799%-115 - C4 - - 5A2S B:[9-388] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPANRQKLDSKKLLGSLASVFVRLPCGGVG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQ----------------------------------------------------
3 PsiBlast_PDB 80.9899%-107 - C4 - - 2VQQ HDAC4_HUMAN A:[7-405] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R---FTTGLVYDTLMLKHQ-----------HAGRIQSIWSRLQETGLRGKCEAIRGRKATLEELQTVHSEAHT-LLYGTNPL----------------------------VDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE-----------------------------------
7 PsiBlast_PDB 80.7899%-112 - C4 - - 5A2S HDAC4_HUMAN A:[9-388] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPANRQKLDSKKLLGSLASVFVRLPCGGVG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQ----------------------------------------------------
4 PsiBlast_PDB 80.7399%-111 - C4 - - 2VQO HDAC4_HUMAN A:[7-405] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R---FTTGLVYDTLMLKHQ------------AGRIQSIWSRLQETGLRGKCEAIRGRKATLEELQTVHSEAHT-LLYGTNPL----------------------------VDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE-----------------------------------
23 PsiBlast_CBE 80.6999%-111 - C4 - - 2VQO B:[7-405] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R---FTTGLVYDTLMLK-------------HAGRIQSIWSRLQETGLRGKCEAIRGRKATLEELQTVHSEAHT-LLYGTNPL-----------------------------DSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE-----------------------------------
21 PsiBlast_CBE 80.4499%-109 - C4 - - 2VQQ B:[7-405] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R---FTTGLVYDTLMLKH--------------GRIQSIWSRLQETGLRGKCEAIRGRKATLEELQTVHSEAHT-LLYGTNPL-----------------------------DSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE-----------------------------------
22 PsiBlast_CBE 79.8899%-114 - C4 - - 2VQV B:[7-405] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R---FTTGLVYDTLMLK-------------HAGRIQSIWSRLQETGLRGKCEAIRGRKATLEELQTVHSEAHT-LLYGTNPL-------------------------------DTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQR-LSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GA--P--D--EVGTGPGVGFNVNMAFT-GGLDPPMGDAE----YLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK-QLM----GL----AGGRIVLALEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRP-NANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE-----------------------------------