@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HDAC5_HUMAN: (2017-06-15 )
MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
Atome Classification :
(92 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680........690.......700.......710.......720.......730.......740...-....-750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850......-.860-.......870.......880.......890.......900--..--.--.--...910.......920.......930.......940.......950.......960.......970.......----980......-.990--.----..----....1000.....--.1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNSPNESDGMSGREPS
L
E
I
LPRTSLHSI
P
V
T
V
E
V
KPVLPRAMPSSMGGGGGGSPSP
V
E
L
R
G
A
L
VGSVD
P
T
L
R
E
Q
Q
L
Q
Q
E
L
L
A
L
K
Q
Q
Q
Q
L
Q
K
Q
L
L
F
A
E
F
Q
K
Q
H
D
H
L
T
R
Q
H
E
V
Q
L
Q
K
H
L
K
Q
Q
Q
E
M
L
A
A
K
Q
Q
Q
E
M
L
A
A
K
R
Q
Q
E
L
E
Q
Q
R
Q
R
E
Q
Q
R
Q
E
E
L
E
K
Q
R
L
E
Q
Q
L
L
I
LRNKEKS
K
E
SAIAS
T
E
V
K
L
R
L
Q
E
F
L
L
SKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEP
N
L
K
V
R
S
R
L
K
Q
K
V
A
E
R
RSSPLLRRKDG
T
V
I
S
T
F
KK
R
A
V
E
I
TGAGP
G
A
S
S
V
C
NSAPGSGPSSPNSSHS
T
I
AENGFTGSVPNI
P
T
E
MLPQHRALPLDSSPN
Q
F
S
L
YTSPSLP
N
I
S
LG
L
Q
A
T
V
T
V
TNSHLTASPKLS
T
Q
Q
E
A
E
R
Q
A
L
Q
S
L
R
QGG
T
L
T
G
K
FMSTSSIPG
C
L
L
G
V
A
LEGDGSPH
G
H
A
S
L
L
Q
H
V
L
L
L
E
Q
A
RQQS
T
L
I
A
V
PLHGQSPLV
T
G
E
R
V
A
T
S
M
R
T
V
GKLPRHRPLSRTQSSPLPQ
S
P
Q
A
L
Q
Q
L
V
M
Q
Q
Q
H
Q
Q
F
L
E
K
Q
K
Q
Q
Q
L
Q
L
G
K
I
L
T
KTGELPRQPTTH
P
E
E
T
E
E
E
L
T
E
Q
Q
E
V
L
LGEGALTMPREGSTESE
S
T
Q
E
D
L
E
EEDEEDDGEE
E
E
D
C
I
Q
V
KDEEGESGAEEGPDLEEPGA
G
Y
K
K
L
FSDAQPLQ
P
L
Q
V
Y
QAPL
S
L
ATV
P
H
Q
A
LGRTQSSPAAPGGMKSPPD
Q
P
V
K
H
L
-
F
TT
G
V
V
Y
D
T
F
M
L
K
H
QCMCGNTHVH
P
E
HA
G
R
I
Q
S
I
W
S
R
L
Q
ET
G
L
L
S
K
C
E
R
IRGRKA
T
L
D
E
I
Q
T
V
H
S
-
E
Y
H
T
-
L
L
YGTSPL
N
R
QKL
D
S
K
K
LL
G
P
I
SQ
K
M
Y
A
V
LPCGGIGVD
S
D
T
V
W
N
E
MHS
S
S
A
V
R
M
A
V
G
C
L
L
E
L
A
F
K
V
AAGELKN
G
F
A
I
IRPPGHHAEEST
A
M
G
F
C
FF
N
S
V
A
I
T
A
K
L
L
Q
Q
K-LNVG-
K
V
L
I
V
D
W
D
I
HHGNGTQQAFYNDP
S
V
L
Y
I
S
L
H
R
YDNGNFFP--GS--G--A--PEEVGGGPGV
G
Y
N
V
N
V
A
W
TGGVDPPIG
D
V
E
Y
L
T
A
F
R
T
V
V
M
P
I
A
HEFSP
D
V
V
L
V
SAG
F
D
A
V
E
GHLSPLGG
Y
S
V
T
----
A
R
C
F
G
H
L
T
R
-
Q
L
M
T
--L----AG----
G
R
V
V
L
A
L
EGGHD
L
--
T
A
IC
D
A
S
E
A
C
V
S
A
L
L
S
V
ELQP
L
D
E
A
V
L
QQKPNI
N
A
V
A
T
L
E
K
V
I
E
I
Q
S
K
H
W
S
C
V
Q
K
F
A
A
G
L
G
R
S
L
R
E
AQAGETE
E
A
E
T
V
S
A
M
A
L
L
S
V
G
A
E
Q
A
Q
A
A
AAREHSPRPAEEPMEQEPAL
6
PsiBlast_PDB
80.61
77%
-120
- C4 -
-
4CBY
5
HDAC4_HUMAN
A:
[9-388]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------------------------------------------------------------
27
PsiBlast_CBE
80.38
77%
-122
- C4 -
-
4CBY
5
D:
[9-389]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
-----------------------------------------------------------
29
PsiBlast_CBE
80.35
77%
-119
- C4 -
-
4CBY
6
HDAC4_HUMAN
B:
[8-387]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
-------------------------------------------------------------
28
PsiBlast_CBE
80.33
77%
-121
- C4 -
-
4CBY
5
HDAC4_HUMAN
C:
[9-388]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------------------------------------------------------------
1
PsiBlast_PDB
80.24
76%
-116
- C4 -
-
2VQJ
9
A:
[8-407]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
L
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
N
E
-----------------------------------------
26
PsiBlast_CBE
80.21
77%
-120
- C4 -
-
5A2S
4
B:
[9-388]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------------------------------------------------------------
7
PsiBlast_PDB
80.10
77%
-118
- C4 -
-
5A2S
4
HDAC4_HUMAN
A:
[9-388]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------------------------------------------------------------
2
PsiBlast_PDB
78.83
76%
-119
- C4 -
-
2VQM
5
A:
[8-407]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
-------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
L
N
R
Q
----
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
N
E
-----------------------------------------
4
PsiBlast_PDB
77.15
76%
-115
- C4 -
-
2VQO
7
HDAC4_HUMAN
A:
[8-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
L
----------------------------
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
Y
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
-------------------------------------------
3
PsiBlast_PDB
76.97
76%
-112
- C4 -
-
2VQQ
7
HDAC4_HUMAN
A:
[8-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
-----------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
L
----------------------------
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
-------------------------------------------
23
PsiBlast_CBE
76.61
76%
-117
- C4 -
-
2VQO
6
B:
[8-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
-------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
L
-----------------------------
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
Y
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
-------------------------------------------
25
PsiBlast_CBE
76.52
77%
-115
- C4 -
-
4CBT
3
HDAC4_HUMAN
B:
[8-388]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
-------------------------------
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
--
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
------------------------------------------------------------
22
PsiBlast_CBE
76.48
76%
-117
- C4 -
-
2VQV
8
B:
[8-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
-------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
L
-------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
Y
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
-------------------------------------------
5
PsiBlast_PDB
76.43
76%
-117
- C4 -
-
2VQV
6
HDAC4_HUMAN
A:
[8-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
--------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
--------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
Y
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
-------------------------------------------
21
PsiBlast_CBE
76.11
76%
-115
- C4 -
-
2VQQ
6
B:
[8-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
--------------
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
L
-----------------------------
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
-------------------------------------------
31
PsiBlast_CBE
75.99
66%
-117
- C4 -
-
3ZNS
5
HDAC7_HUMAN
B:
[38-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
----
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
N
--
L
----
A
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
-----------------------------------------------------------
24
PsiBlast_CBE
74.20
77%
-118
- C4 -
-
4CBT
3
C:
[8-389]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
----
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
T
-
L
L
Y
G
T
N
P
L
--------------------------------
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
--
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
----
A
R
C
F
G
Y
L
T
K
-
Q
L
M
G
--
L
----
A
G
----
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
------
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
-----------------------------------------------------------
32
PsiBlast_CBE
73.88
66%
-116
- C4 -
-
3ZNR
4
C:
[39-419]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
V
-
L
L
Y
G
T
N
P
----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
----
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
N
--
L
----
A
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------------------------------------------------------------
38
PsiBlast_CBE
73.61
66%
-117
- C4 -
-
3C0Y
4
C:
[39-419]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
V
-
L
L
Y
G
T
N
-----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
----
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
N
--
L
----
A
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------------------------------------------------------------
34
PsiBlast_CBE
73.54
66%
-118
- C4 -
-
3C10
5
C:
[39-419]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
V
-
L
L
Y
G
T
N
P
----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
----
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
N
--
L
----
A
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------------------------------------------------------------
30
PsiBlast_CBE
73.40
66%
-119
- C4 -
-
3ZNS
5
C:
[39-419]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
V
-
L
L
Y
G
T
N
P
----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
----
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
N
--
L
----
A
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------------------------------------------------------------
36
PsiBlast_CBE
73.37
66%
-114
- C4 -
-
3C0Z
5
C:
[39-419]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
V
-
L
L
Y
G
T
N
P
----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
----
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
N
--
L
----
A
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
------------------------------------------------------------
9
PsiBlast_PDB
71.83
66%
-49
- C4 -
-
3C0Z
5
HDAC7_HUMAN
A:
[35-420]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
----
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
N
--
L
----
A
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
-----------------------------------------------------------
10
PsiBlast_PDB
71.71
66%
-45
- C4 -
-
3C10
5
HDAC7_HUMAN
A:
[35-420]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
----
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
N
--
L
----
A
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
-----------------------------------------------------------
12
PsiBlast_PDB
70.41
66%
-47
- C4 -
-
3ZNS
5
HDAC7_HUMAN
A:
[36-421]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
----
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
N
--
L
----
A
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
----------------------------------------------------------
11
PsiBlast_PDB
70.31
66%
-48
- C4 -
-
3ZNR
5
HDAC7_HUMAN
A:
[36-421]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
----
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
N
--
L
----
A
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
----------------------------------------------------------
37
PsiBlast_CBE
70.28
66%
-49
- C4 -
-
3C0Z
5
HDAC7_HUMAN
B:
[36-421]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
----
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
N
--
L
----
A
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
----------------------------------------------------------
35
PsiBlast_CBE
70.10
66%
-48
- C4 -
-
3C10
5
HDAC7_HUMAN
B:
[36-421]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
--
G
--
A
--
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
----
A
K
C
F
G
Y
M
T
Q
-
Q
L
M
N
--
L
----
A
G
----
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
----------------------------------------------------------
190
HHSearch
62.70
45%
-59
- C4 -
-
5G0H
14
?
A:
[404-763]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
----
P
R
D
L
--------------
N
R
L
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
--
E
--
D
AN
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
---
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
V
N
----------------------------------------------------------
48
PsiBlast_CBE
62.56
42%
-60
- C4 -
-
5EF8
6
?
A:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
20
PsiBlast_PDB
62.47
42%
-59
- C4 -
-
5EF7
4
?
A:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
49
PsiBlast_CBE
62.38
42%
-59
- C4 -
-
5EF7
5
?
B:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
--
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
17
PsiBlast_PDB
61.98
42%
-60
- C4 -
-
5EEK
30
?
A:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
--
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
46
PsiBlast_CBE
61.97
42%
-60
- C4 -
-
5EFB
4
?
D:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
--
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
47
PsiBlast_CBE
61.86
42%
-58
- C4 -
-
5EF8
7
?
B:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
55
PsiBlast_CBE
61.73
42%
-59
- C4 -
-
5EFN
5
?
A:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
18
PsiBlast_PDB
61.68
42%
-62
- C4 -
-
5EEM
5
?
B:
[10-363]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
---
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
-------------------------------------------------------------
43
PsiBlast_CBE
61.62
42%
-58
- C4 -
-
5EFH
9
?
A:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
50
PsiBlast_CBE
61.59
42%
-57
- C4 -
-
5EEN
5
?
A:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
19
PsiBlast_PDB
61.43
42%
-60
- C4 -
-
5EEN
4
?
B:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
----
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
14
PsiBlast_PDB
61.42
42%
-59
- C4 -
-
5G0H
14
?
A:
[407-761]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
-
W
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
54
PsiBlast_CBE
61.40
42%
-60
- C4 -
-
5EFN
6
?
B:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
53
PsiBlast_CBE
61.34
42%
-57
- C4 -
-
5EFK
8
?
B:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
F
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
-
H
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
15
PsiBlast_PDB
61.33
42%
-55
- C4 -
-
5G0J
5
?
A:
[407-761]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
-
W
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
42
PsiBlast_CBE
61.20
42%
-57
- C4 -
-
5EFH
7
?
D:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
-
D
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
-
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
ED
A
--
N
--
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
----
P
E
G
Y
A
H
L
T
H
-
Q
L
M
S
--
L
----
A
A
----
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
L
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
------------------------------------------------------------
191
HHSearch
60.32
38%
-69
- C4 -
-
5G0G
9
?
A:
[21-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
-
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
--
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
-
K
E
Y
V
-
E
L
M
K
S
T
Q
N
M
T
E
----
E
E
L
------
K
T
L
----
A
---
E
K
Y
D
S
V
Y
L
H
-
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
--
H
L
--
K
ES
D
--
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
V
---
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
--
P
K
G
G
M
Q
V
S
----
P
E
C
F
S
I
L
T
H
-
M
L
K
G
--
V
----
A
Q
----
G
R
L
V
L
A
L
E
G
G
Y
N
L
--
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
P
C
P
H
L
P
S
S
---
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
-----------------------------------------------------------
58
PsiBlast_CBE
60.00
37%
-43
* C4 *
-
5G0G
9
?
A:
[25-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
A
S
H
--
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
-
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
------
L
A
E
K
Y
-------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
HL
K
E
--
S
--
D
--
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
-
K
V
G
M
E
S
G
D
--
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
--
D
P
K
G
G
M
Q
V
S
----
P
E
C
F
S
I
L
T
H
-
M
L
K
G
--
V
----
A
Q
----
G
R
L
V
L
A
L
E
G
G
Y
N
L
--
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
F
----------------------------------------------------------
59
PsiBlast_CBE
59.12
37%
-43
- C4 -
-
5EEF
6
?
B:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
A
S
H
--
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
-
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
------
L
A
E
K
Y
-------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
HL
K
E
--
S
--
D
--
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
-
K
V
G
M
E
S
G
D
--
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
--
D
P
K
G
G
M
Q
V
S
----
P
E
C
F
S
I
L
T
H
-
M
L
K
G
--
V
----
A
Q
----
G
R
L
V
L
A
L
E
G
G
Y
N
L
--
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
-----------------------------------------------------------
60
PsiBlast_CBE
58.87
37%
-44
- C4 -
-
5EEF
7
?
A:
[10-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
V
D
A
F
T
R
F
H
-----
S
H
--
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
-
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
------
L
A
E
K
Y
-------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
HL
K
E
--
S
--
D
--
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
-
K
V
G
M
E
S
G
D
--
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
--
D
P
K
G
G
M
Q
V
S
----
P
E
C
F
S
I
L
T
H
-
M
L
K
G
--
V
----
A
Q
----
G
R
L
V
L
A
L
E
G
G
Y
N
L
--
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
-----------------------------------------------------------
199
HHSearch
53.84
34%
-115
- C4 -
-
5JI5
6
?
A:
[10-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
G
F
Y
S
H
A
D
C
L
Q
H
E
M
----
G
Q
W
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
L
A
D
E
A
A
L
L
R
V
H
T
-
K
A
H
V
-
D
Y
L
R
A
R
S
P
Q
S
----------------------
G
Y
A
E
I
D
P
D
T
S
M
N
P
-
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
V
-
H
K
L
E
-
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
---
P
F
Y
P
--
F
T
--
G
--
A
--
D
N
------
Q
A
P
N
M
C
N
V
P
I
A
A
R
----
S
K
G
M
V
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
E
D
--
D
L
G
N
M
A
L
V
----
E
D
D
Y
A
W
I
T
Q
-
Q
I
R
L
--
V
A
D
K
Y
A
K
----
G
R
I
V
S
C
L
E
G
G
Y
N
L
--
S
A
L
G
R
S
V
V
A
H
V
R
A
L
A
D
--------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
47.16
32%
-48
- C4 -
-
5JI5
6
?
A:
[28-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
L
A
D
E
A
A
L
L
R
V
H
T
-
K
A
H
V
D
Y
L
R
A
R
S
P
----------------
Q
S
G
Y
A
-------
E
I
D
P
D
T
S
M
N
P
-
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
V
-
H
K
L
E
-
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
P
---
F
Y
P
--
F
T
--
G
--
A
--
D
N
Q
---
A
P
N
M
-
C
N
V
P
I
A
A
R
S
------
K
G
M
V
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
--
H
R
E
D
D
L
G
N
M
A
L
V
----
E
D
D
Y
A
W
I
T
Q
-
Q
I
R
L
--
V
----
A
D
K
YAK
G
R
I
V
S
C
L
E
G
G
Y
N
L
--
S
A
L
G
R
S
V
V
A
H
V
R
A
L
A
D
--------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
44.49
31%
-132
- C4 -
-
3F0R
5
HDAC8_HUMAN
C:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
44.43
31%
-131
- C4 -
-
1T69
2
HDAC8_HUMAN
A:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
44.22
31%
-130
- C4 -
-
5D1B
5
HDAC8_HUMAN
B:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
44.21
31%
-129
- C4 -
-
3F0R
5
HDAC8_HUMAN
A:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
44.12
31%
-132
- C4 -
-
3SFF
4
HDAC8_HUMAN
A:
[119-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
44.09
31%
-127
- C4 -
-
3SFH
6
HDAC8_HUMAN
A:
[119-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
43.85
31%
-133
- C4 -
-
5FCW
7
?
A:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
43.73
31%
-132
- C4 -
-
5FCW
7
?
B:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
43.67
31%
-130
- C4 -
-
1W22
5
HDAC8_HUMAN
B:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
43.66
31%
-126
- C4 -
-
5D1B
5
HDAC8_HUMAN
A:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
43.57
31%
-129
- C4 -
-
1T64
5
HDAC8_HUMAN
A:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
43.54
31%
-130
- C4 -
-
1T64
5
HDAC8_HUMAN
B:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
AN
T
A
R
C
--------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
43.47
31%
-131
- C4 -
-
1T67
4
HDAC8_HUMAN
A:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
43.29
31%
-130
- C4 -
-
1W22
5
HDAC8_HUMAN
A:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
43.27
31%
-128
- C4 -
-
3F0R
5
HDAC8_HUMAN
B:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
43.25
31%
-131
- C4 -
-
3F07
4
HDAC8_HUMAN
A:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
43.16
31%
-130
- C4 -
-
2V5X
5
HDAC8_HUMAN
A:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
42.82
31%
-129
- C4 -
-
2V5X
5
HDAC8_HUMAN
B:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
42.80
31%
-131
- C4 -
-
3F07
4
HDAC8_HUMAN
B:
[118-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
----
P
V
G
I
G
K
C
L
K
-
Y
I
L
Q
--
W
----
Q
L
----
A
T
L
I
L
G
-
G
G
G
Y
N
L
A
N
T
A
R
C
--------------------------------------------------------------------------------------------------------------
123
PsiBlast_CBE
42.02
31%
-137
- C4 -
-
5DC7
4
HDAC8_HUMAN
B:
[118-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
A
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
P
V
G
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
----
G
G
----
G
G
F
N
L
A
---------------------------------------------------------------------------------------------------------------------------
118
PsiBlast_CBE
41.81
32%
-132
- C4 -
-
5DC8
4
HDAC8_HUMAN
A:
[118-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
A
-------
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
P
V
G
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
----
G
G
----
G
G
F
N
L
A
---------------------------------------------------------------------------------------------------------------------------
121
PsiBlast_CBE
41.62
31%
-136
- C4 -
-
5DC6
4
HDAC8_HUMAN
B:
[118-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
N
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
PVGI
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
LI
L
----
G
G
----
G
G
F
N
L
A
---------------------------------------------------------------------------------------------------------------------------
122
PsiBlast_CBE
41.53
31%
-137
- C4 -
-
5DC6
3
HDAC8_HUMAN
A:
[118-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
N
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
P
V
G
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
----
G
G
----
G
G
F
N
L
A
---------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
41.32
32%
-132
- C4 -
-
2V5W
6
HDAC8_HUMAN
B:
[118-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
P
V
G
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
----
G
G
----
G
G
F
N
L
A
---------------------------------------------------------------------------------------------------------------------------
119
PsiBlast_CBE
41.31
31%
-132
- C4 -
-
4QA5
7
HDAC8_HUMAN
B:
[118-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
T
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
P
V
G
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
----
G
G
----
G
G
F
N
L
A
---------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
41.13
32%
-135
- C4 -
-
4QA7
6
HDAC8_HUMAN
A:
[118-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
P
V
G
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
----
G
G
----
G
G
F
N
L
A
---------------------------------------------------------------------------------------------------------------------------
112
PsiBlast_CBE
41.11
32%
-134
- C4 -
-
2V5W
5
HDAC8_HUMAN
A:
[118-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
P
V
G
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
----
G
G
----
G
G
F
N
L
A
---------------------------------------------------------------------------------------------------------------------------
115
PsiBlast_CBE
40.90
32%
-130
- C4 -
-
4QA6
8
HDAC8_HUMAN
B:
[118-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
N
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
PVGI
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
LI
L
----
G
G
----
G
G
F
N
L
A
---------------------------------------------------------------------------------------------------------------------------
124
PsiBlast_CBE
40.81
31%
-135
- C4 -
-
5DC7
3
HDAC8_HUMAN
A:
[118-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
A
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
P
V
G
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
----
G
G
----
G
G
F
N
L
A
---------------------------------------------------------------------------------------------------------------------------
120
PsiBlast_CBE
40.68
31%
-129
- C4 -
-
4QA5
7
HDAC8_HUMAN
A:
[118-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
T
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
P
V
G
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
----
G
G
----
G
G
F
N
L
A
---------------------------------------------------------------------------------------------------------------------------
116
PsiBlast_CBE
40.68
32%
-130
- C4 -
-
4QA6
8
HDAC8_HUMAN
A:
[118-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
-
N
W
S
G
G
W
-------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
K
-
F
E
---
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
--
G
T
--
G
--
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
N
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
--
D
P
M
C
S
F
N
M
T
P
V
G
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
I
L
----
G
G
----
G
G
F
N
L
A
---------------------------------------------------------------------------------------------------------------------------
127
PsiBlast_CBE
39.89
31%
-76
- C4 -
-
4ZUQ
6
APHA_MYCRA
B:
[142-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L-
G
--
Y
--
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
-----
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
--
D
P
I
S
F
F
K
L
T
----
S
P
D
Y
I
T
M
G
R
-
T
I
A
A
-------
S
G
----
V
P
L
L
V
V
M
E
G
G
Y
G
V
--
P
E
I
---------------------------------------------------------------------------------------------------------------
134
PsiBlast_CBE
39.72
31%
-74
- C4 -
-
4ZUN
5
APHA_MYCRA
A:
[142-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L-
G
--
Y
--
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
-----
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
--
D
P
I
S
F
F
K
L
T
----
S
P
D
Y
I
T
M
G
R
-
T
I
A
A
-------
S
G
----
V
P
L
L
V
V
M
E
G
G
Y
G
V
--
P
E
I
---------------------------------------------------------------------------------------------------------------
129
PsiBlast_CBE
39.32
31%
-74
- C4 -
-
4ZUP
6
APHA_MYCRA
B:
[142-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L-
G
--
Y
--
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
-----
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
--
D
P
I
S
F
F
K
L
T
----
S
P
D
Y
I
T
M
G
R
-
T
I
A
A
-------
S
G
----
V
P
L
L
V
V
M
E
G
G
Y
G
V
--
P
E
I
---------------------------------------------------------------------------------------------------------------
132
PsiBlast_CBE
39.17
31%
-75
- C4 -
-
4ZUO
5
APHA_MYCRA
A:
[142-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L-
G
--
Y
--
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
-----
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
--
D
P
I
S
F
F
K
L
T
----
S
P
D
Y
I
T
M
G
R
-
T
I
A
A
-------
S
G
----
V
P
L
L
V
V
M
E
G
G
Y
G
V
--
P
E
I
---------------------------------------------------------------------------------------------------------------
136
PsiBlast_CBE
38.74
31%
-75
- C4 -
-
4ZUM
6
APHA_MYCRA
A:
[142-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L-
G
--
Y
--
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
-----
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
--
D
P
I
S
F
F
K
L
T
----
S
P
D
Y
I
T
M
G
R
-
T
I
A
A
-------
S
G
----
V
P
L
L
V
V
M
E
G
G
Y
G
V
--
P
E
I
---------------------------------------------------------------------------------------------------------------
133
PsiBlast_CBE
38.71
31%
-74
- C4 -
-
4ZUN
4
APHA_MYCRA
B:
[142-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L-
G
--
Y
--
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
-----
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
--
D
P
I
S
F
F
K
L
T
----
S
P
D
Y
I
T
M
G
R
-
T
I
A
A
-------
S
G
----
V
P
L
L
V
V
M
E
G
G
Y
G
V
--
P
E
I
---------------------------------------------------------------------------------------------------------------
128
PsiBlast_CBE
38.62
31%
-76
- C4 -
-
4ZUQ
6
APHA_MYCRA
A:
[142-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L-
G
--
Y
--
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
-----
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
--
D
P
I
S
F
F
K
L
T
----
S
P
D
Y
I
T
M
G
R
-
T
I
A
A
-------
S
G
----
V
P
L
L
V
V
M
E
G
G
Y
G
V
--
P
E
I
---------------------------------------------------------------------------------------------------------------
131
PsiBlast_CBE
38.55
31%
-73
- C4 -
-
4ZUO
6
APHA_MYCRA
B:
[142-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L-
G
--
Y
--
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
-----
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
--
D
P
I
S
F
F
K
L
T
----
S
P
D
Y
I
T
M
G
R
-
T
I
A
A
-------
S
G
----
V
P
L
L
V
V
M
E
G
G
Y
G
V
--
P
E
I
---------------------------------------------------------------------------------------------------------------
130
PsiBlast_CBE
38.51
31%
-73
- C4 -
-
4ZUP
8
APHA_MYCRA
A:
[142-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L-
G
--
Y
--
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
-----
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
--
D
P
I
S
F
F
K
L
T
----
S
P
D
Y
I
T
M
G
R
-
T
I
A
A
-------
S
G
----
V
P
L
L
V
V
M
E
G
G
Y
G
V
--
P
E
I
---------------------------------------------------------------------------------------------------------------
135
PsiBlast_CBE
38.05
31%
-74
- C4 -
-
4ZUM
5
APHA_MYCRA
B:
[142-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L-
G
--
Y
--
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
-----
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
--
D
P
I
S
F
F
K
L
T
----
S
P
D
Y
I
T
M
G
R
-
T
I
A
A
-------
S
G
----
V
P
L
L
V
V
M
E
G
G
Y
G
V
--
P
E
I
---------------------------------------------------------------------------------------------------------------