@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HDAC6_HUMAN: (2017-06-15 )
MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHPH
Atome Classification :
(51 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490-.....-..-500.......510.......520.......530--.........540.----......550........560------.----------------...-------------...570.......580.......590.......600.......610.......620.......630..---.....640........650.......660.......670.......680.......690.......700.....---..710.......720.......730.......740....--.--..750.......760.....----..770--.........780.......790.......800-.........810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTSTGQDS
T
T
T
R
Q
R
RSRQNPQSPPQDSSVTSKRNIKKGAVPRSI
P
N
L
A
E
V
K
KKG
K
M
K
K
L
G
Q
A
M
E
E
D
L
I
VGLQGMDL
N
L
E
A
E
ALAGT
G
L
V
L
D
EQLN
E
F
H
C
LWDDSFPE
G
P
E
R
L
H
A
I
K
E
Q
L
I
Q
E
G
L
L
D
R
C
V
S
F
Q
A
R
FAEKE
E
L
M
L
V
H
S
L
E
Y
I
D
L
M
E
T
T
Q
YMNEG
E
L
R
V
L
A
DTY
D
S
V
Y
LHPNSY
S
C
A
C
LASG
S
V
L
R
L
V
D
A
V
L
G
A
E
I
RN
G
M
A
I
IRPPGH
H
A
Q
H
S
LMD
G
Y
C
M
F
N
H
V
A
V
A
A
R
Y
A
Q
Q
K
H
R
I
R
R
V
L
I
V
D
W
DVHHGQG
T
Q
F
T
FDQDP
S
V
L
Y
F
S
I
H
R
YEQGRFWPHLKASNWSTTGFGQGQ
G
Y
T
I
NV
P
W
N
QVGMR
D
A
D
Y
I
A
A
F
L
H
V
L
L
P
V
A
LEFQP
Q
L
V
L
V
AAG
F
D
ALQGDPKGEMAATP
A
G
F
A
Q
L
T
H
L
L
M
GLAG
G
K
L
I
L
S
LEGGY
N
L
R
A
L
A
E
G
V
S
A
S
L
H
T
LLGDPCPMLESPGAPCRSA
Q
A
S
V
S
C
A
L
E
A
L
E
P
F
W
E
V
L
VRSTETVERDNMEEDNVEESEEEGPWEPP
V
L
P
I
LT
W
P
V
L
QSRTG
L
V
Y
D
Q
N
M
M
N
H-CNLWD-SH-H
P
E
V
P
Q
R
I
L
R
I
M
C
R
L
E
E
LGLA
G
R
C
L
T
LTPRP----ATE
A
E
L
L
T
CHS
A
E
----
Y
V
G
H
L
R
A
-
T
E
K
M
K
T
R
E
L
H
RE------S----------------SNF-------------
D
S
I
Y
ICPS
T
F
A
C
A
Q
LA
T
G
A
A
C
R
L
V
E
A
V
LSGEVLN
G
A
A
VVRPPGHHAEQDAA
C
G
F
C
F
F
N
S
V
A
V
A
A
R
H
A
Q---TISG
H
A
L
-
R
I
L
I
V
D
W
D
V
HHGNGTQHMFEDDP
S
V
L
Y
V
S
L
H
RYDHGTFFPMGDEGASSQIGRAAGT
G
F
T
V
N
V
A
WNG---PRMG
D
A
D
Y
L
A
A
W
H
R
L
V
L
P
I
A
Y
EFNP
E
L
V
L
V
SAGFDAARG--D--PLGGCQVSP
E
G
Y
A
H
L
T
H
L
L
M
----
G
LA----S
G
R
I
I
L
I
L
EGGYN
L
T
S
I
S
E
S
M
A
A
C
T
R
S
L
LG---DPP
P
L
L
TLPRPPLS
G
A
L
A
S
I
T
E
T
I
Q
V
H
R
R
Y
W
R
SL
R
V
M
K
V
EDREGPSSS
K
L
V
TKKAPQPAK
P
R
L
A
E
R
M
T
T
R
E
K
K
V
L
E
A
GMGKVTSASFGEESTPGQTNS
E
T
A
V
V
A
L
TQDQPSEAATG
G
A
T
L
A
Q
T
I
S
E
A
AIG
G
A
MLGQTTSEEAVGGATPDQTTSEETVG
G
A
I
LDQTTSEDAVGGATLGQTTSEEAVGG
A
T
L
A
Q
T
T
S
E
A
AMEGATLDQTTSEEAPGG
T
E
L
IQTPLASSTDHQTPPTSPVQGTTPQI
S
P
S
T
L
I
G
S
L
R
T
L
ELGSESQGASESQAPGEENLLGEAAGG
Q
D
M
A
D
S
M
L
M
QGSRGLTDQ
A
I
F
Y
AVTPLPWCP
H
L
V
A
VCPIPAAGLDVTQPCGDCGTIQEN
W
V
C
L
S
C
Y
Q
V
Y
C
G
RYIN
G
H
M
L
Q
HHGNSG
H
P
L
V
L
S
Y
ID
L
S
A
W
C
Y
Y
C
Q
A
Y
V
H
H
Q
A
L
L
D
V
K
N
I
A
H
QNKFGEDMPHPH
121
Fugue
84.54
57%
-107
- C3 -
-
5G0J
9
?
A:
[17-772]
----------------------------------------------------------------------------
V
Q
G
K
S
K
A
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
L
A
E
K
Y
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
P
C
P
H
L
P
S
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
----
K
S
L
Q
T
F
E
G
G
P
L
S
E
V
S
--------
P
L
P
A
P
V
C
A
--
E
V
K
V
S
S
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
V
-
N
I
P
E
S
L
R
L
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.93
57%
-110
- C3 -
-
5G0J
9
?
A:
[17-762]
---------------------------------------------------------------------------
V
Q
G
K
S
K
A
-
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
L
A
E
K
Y
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
P
C
P
H
L
P
S
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
----
K
S
L
Q
T
F
E
G
G
P
L
S
E
V
S
--------
P
L
P
A
P
V
C
A
E
V
K
--
V
S
S
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.34
56%
-115
- C3 -
-
5G0I
10
?
A:
[36-777]
-------------------------------------------------------------------------------
S
K
A
-
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
L
A
E
K
Y
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
P
C
P
H
L
P
S
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
----
K
S
L
Q
T
F
E
--------------------------------
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.29
56%
-114
- C3 -
-
5G0I
9
?
B:
[37-777]
--------------------------------------------------------------------------------
K
A
-
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
L
A
E
K
Y
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
P
C
P
H
L
P
S
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
----
K
S
L
Q
T
F
---------------------------------
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.18
100%
-127
- C3 -
-
5EDU
4
HDAC6_HUMAN (first)
B:
[389-745]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
T
G
L
V
Y
D
Q
N
M
M
N
H
-
C
N
L
W
D
-
S
H
-
H
P
E
V
P
Q
R
I
L
R
I
M
C
R
L
E
E
L
G
L
A
G
R
C
L
T
L
T
P
R
P
----
A
T
E
A
E
L
L
T
C
H
S
A
E
----
Y
V
G
H
L
R
A
-
T
E
K
M
K
T
R
E
L
H
R
E
------
S
----------------
S
N
F
-------------
D
S
I
Y
I
C
P
S
T
F
A
C
A
Q
L
A
T
G
A
A
C
R
L
V
E
A
V
L
S
G
E
V
L
N
G
A
A
V
V
R
P
P
G
H
H
A
E
Q
D
A
A
C
G
F
C
F
F
N
S
V
A
V
A
A
R
H
A
Q
---
T
I
S
G
H
A
L
-
R
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
M
F
E
D
D
P
S
V
L
Y
V
S
L
H
R
Y
D
H
G
T
F
F
P
M
G
D
E
G
A
S
S
Q
I
G
R
A
A
G
T
G
F
T
V
N
V
A
W
N
G
---
P
R
M
G
D
A
D
Y
L
A
A
W
H
R
L
V
L
P
I
A
Y
E
F
N
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
C
Q
V
S
P
E
G
Y
A
H
L
T
H
L
L
M
----
G
L
A
----
S
G
R
I
I
L
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
A
A
C
T
R
S
L
L
G
---
D
P
P
P
L
L
T
--
R
P
P
L
S
G
A
L
A
S
I
T
E
T
I
Q
V
H
R
R
Y
W
R
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
73.84
100%
-132
- C3 -
-
5EDU
4
HDAC6_HUMAN (first)
A:
[389-745]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
T
G
L
V
Y
D
Q
N
M
M
N
H
-
C
N
L
W
D
-
S
H
-
H
P
E
V
P
Q
R
I
L
R
I
M
C
R
L
E
E
L
G
L
A
G
R
C
L
T
L
T
P
R
P
----
A
T
E
A
E
L
L
T
C
H
S
A
E
----
Y
V
G
H
L
R
A
-
T
E
K
M
K
T
R
E
L
H
R
E
------
S
----------------
S
N
F
-------------
D
S
I
Y
I
C
P
S
T
F
A
C
A
Q
L
A
T
G
A
A
C
R
L
V
E
A
V
L
S
G
E
V
L
N
G
A
A
V
V
R
P
P
G
H
H
A
E
Q
D
A
A
C
G
F
C
F
F
N
S
V
A
V
A
A
R
H
A
Q
---
T
I
S
G
H
A
L
-
R
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
M
F
E
D
D
P
S
V
L
Y
V
S
L
H
R
Y
D
H
G
T
F
F
P
M
G
D
E
G
A
S
S
Q
I
G
R
A
A
G
T
G
F
T
V
N
V
A
W
N
G
---
P
R
M
G
D
A
D
Y
L
A
A
W
H
R
L
V
L
P
I
A
Y
E
F
N
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
C
Q
V
S
P
E
G
Y
A
H
L
T
H
L
L
M
----
G
L
A
----
S
G
R
I
I
L
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
A
A
C
T
R
S
L
L
G
---
D
P
P
P
L
L
T
L
P
R
P
P
L
S
G
A
L
A
S
I
T
E
T
I
Q
V
H
R
R
Y
W
R
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
72.66
98%
-126
- C3 -
-
5EDU
4
HDAC6_HUMAN (first)
B:
[381-745]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
Q
T
N
A
A
A
S
R
T
G
L
V
Y
D
Q
N
M
M
N
H
-
C
N
L
W
D
-
S
H
-
H
P
E
V
P
Q
R
I
L
R
I
M
C
R
L
E
E
L
G
L
A
G
R
C
L
T
L
T
P
R
P
----
A
T
E
A
E
L
L
T
C
H
S
A
E
----
Y
V
G
H
L
R
A
-
T
E
K
M
K
T
R
E
L
H
R
E
------
S
----------------
S
N
F
-------------
D
S
I
Y
I
C
P
S
T
F
A
C
A
Q
L
A
T
G
A
A
C
R
L
V
E
A
V
L
S
G
E
V
L
N
G
A
A
V
V
R
P
P
G
H
H
A
E
Q
D
A
A
C
G
F
C
F
F
N
S
V
A
V
A
A
R
H
A
Q
---
T
I
S
G
H
A
L
-
R
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
M
F
E
D
D
P
S
V
L
Y
V
S
L
H
R
Y
D
H
G
T
F
F
P
M
G
D
E
G
A
S
S
Q
I
G
R
A
A
G
T
G
F
T
V
N
V
A
W
N
G
---
P
R
M
G
D
A
D
Y
L
A
A
W
H
R
L
V
L
P
I
A
Y
E
F
N
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
C
Q
V
S
P
E
G
Y
A
H
L
T
H
L
L
M
----
G
L
A
----
S
G
R
I
I
L
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
A
A
C
T
R
S
L
L
G
---
D
P
P
P
L
L
T
--
R
P
P
L
S
G
A
L
A
S
I
T
E
T
I
Q
V
H
R
R
Y
W
R
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
63.68
57%
-123
- C3 -
-
5G0H
14
?
A:
[404-762]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
63.65
57%
-122
- C3 -
-
5G0H
14
?
A:
[404-763]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
V
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.55
58%
-128
- C3 -
-
5EFB
4
?
D:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
--
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
63.17
58%
-124
- C3 -
-
5EFK
8
?
B:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
F
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
-
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
63.09
58%
-126
- C3 -
-
5EEM
3
?
A:
[10-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
--
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
62.85
58%
-123
- C3 -
-
5EFN
6
?
B:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
62.84
58%
-122
- C3 -
-
5EFJ
9
?
D:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
-
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
62.81
58%
-126
- C3 -
-
5EF8
7
?
B:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.77
58%
-126
- C3 -
-
5EEK
30
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
--
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
62.72
58%
-123
- C3 -
-
5EFN
5
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
62.62
58%
-127
- C3 -
-
5EEN
4
?
B:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
----
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.59
58%
-126
- C3 -
-
5EFG
4
?
D:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
62.51
58%
-126
- C3 -
-
5EF7
5
?
B:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
--
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
62.44
58%
-125
- C3 -
-
5EFH
9
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.27
58%
-127
- C3 -
-
5EEM
5
?
B:
[10-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
---
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.16
58%
-124
- C3 -
-
5EF7
4
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
62.11
58%
-123
- C3 -
-
5EFH
7
?
D:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
-
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.38
58%
-122
- C3 -
-
5EF8
6
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
61.32
58%
-122
- C3 -
-
5EEN
5
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
-
H
N
M
W
D
-
S
H
-
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
----
A
T
E
E
E
L
A
L
C
H
S
S
K
----
H
I
S
I
I
K
S
-
S
E
H
M
K
P
R
D
L
N
R
L
------
G
----------------
D
E
Y
-------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
---
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
---
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
----
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
---
D
S
P
P
S
L
D
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
60.53
48%
-125
- C3 -
-
5G0G
9
?
A:
[21-379]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
-
H
C
L
W
D
-
A
S
-
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
----
V
T
E
D
E
L
L
L
V
H
T
K
E
----
Y
V
E
L
M
K
S
-
T
Q
N
M
T
E
E
E
L
K
T
L
------
A
----------------
E
K
Y
-------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
---
K
R
H
R
-
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
---
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
--
D
--
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
----
G
V
A
----
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
---
D
P
C
P
H
L
P
S
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
47.37
46%
-60
- C3 -
-
2VQV
6
HDAC4_HUMAN
A:
[10-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
T
L
M
L
K
---------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
----
A
T
L
E
E
L
Q
T
V
H
S
E
A
----
H
T
-
L
L
Y
G
-
T
N
P
------------------------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
RL
S
V
S
-----
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
GLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
HP
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
----
G
L
A
----
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
47.36
46%
-38
- C3 -
-
2VQO
6
B:
[10-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
T
L
M
L
K
--------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
----
A
T
L
E
E
L
Q
T
V
H
S
E
A
----
H
T
-
L
L
Y
G
-
T
N
P
L
----------------------------------DS-----------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
RL
S
V
S
-----
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
GLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
HP
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
----
G
L
A
----
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
47.13
45%
-31
- C3 -
-
3C10
5
HDAC7_HUMAN
A:
[40-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
-
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
----
A
S
L
E
E
L
Q
S
V
H
S
E
R
----
H
V
-
L
L
Y
G
-
T
N
P
L
S
R
L
K
L
D
N
G
------
K
L
A
G
L
L
A
QVMLPCGGVG
V
D
T
-------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
---
Q
Q
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
GLD
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
--
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
----
N
L
A
----
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
46.90
46%
-39
- C3 -
-
2VQQ
6
B:
[10-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
T
L
M
L
K
H
---------------
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
----
A
T
L
E
E
L
Q
T
V
H
S
E
A
----
H
T
-
L
L
Y
G
-
T
N
P
L
----------------------------------DS-----------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
-----
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
GLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
HP
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
----
G
L
A
----
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
46.86
46%
-61
- C3 -
-
2VQV
8
B:
[10-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
T
L
M
L
K
--------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
----
A
T
L
E
E
L
Q
T
V
H
S
E
A
----
H
T
-
L
L
Y
G
-
T
N
P
L
-----------------------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
RL
S
V
S
-----
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
GLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
HP
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
----
G
L
A
----
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
46.70
46%
-38
- C3 -
-
2VQM
5
A:
[10-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
--------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
----
A
T
L
E
E
L
Q
T
V
H
S
E
A
----
H
T
-
L
L
Y
G
-
T
N
P
L
N
R
Q
----
K
K
L
L
G
S
L
A
----------------
S
V
F
VRLPCGGVGVDS-
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
RL
S
V
S
-----
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
GLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
HP
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
----
G
L
A
----
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
46.31
45%
-30
- C3 -
-
3C0Z
5
HDAC7_HUMAN
A:
[40-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
-
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
----
A
S
L
E
E
L
Q
S
V
H
S
E
R
----
H
V
-
L
L
Y
G
-
T
N
P
L
S
R
L
K
L
D
N
G
------
K
L
A
G
L
L
A
QVMLPCGGVG
V
D
T
-------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
---
Q
Q
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
GLD
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
--
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
----
N
L
A
----
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
46.25
46%
-17
- C3 -
-
4CBT
3
HDAC4_HUMAN
B:
[10-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
-
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
----
A
T
L
E
E
L
Q
T
V
H
S
E
A
----
H
T
-
L
L
Y
G
-
T
N
P
-----------------------------------S------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
QRL
S
V
S
-----
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
GLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
HP
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
----
G
L
A
----
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N--
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
46.16
45%
-32
- C3 -
-
3ZNS
5
HDAC7_HUMAN
B:
[40-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
-
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
----
A
S
L
E
E
L
Q
S
V
H
S
E
R
----
H
V
-
L
L
Y
G
-
T
N
P
L
S
R
L
K
L
D
N
G
------
K
L
A
G
L
L
A
QVMLPCGGVG
V
D
T
-------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
---
Q
Q
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
GLD
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
--
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
----
N
L
A
----
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
46.00
46%
-34
- C3 -
-
5A2S
4
HDAC4_HUMAN
A:
[10-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
-
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
----
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
A
N
-
R
Q
K
L
D
S
K
K
L
L
G
S
------
L
----------------
A
S
V
F
V
R
L
PCGGVGVDS
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
-----
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
GLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
HP
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
----
G
L
A
----
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
45.67
46%
-34
- C3 -
-
5A2S
4
B:
[10-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
-
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
----
A
T
L
E
E
L
Q
T
V
H
S
E
A
HTLL
Y
G
T
N
P
A
N
-
R
Q
K
L
D
S
K
K
L
L
G
S
------
L
----------------
A
S
V
FVRLPCGGVGVDS
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
QRL
S
V
S
-----
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
GLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
HP
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
----
G
L
A
----
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
45.64
45%
-23
- C3 -
-
3ZNS
5
HDAC7_HUMAN
A:
[40-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
-
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
----
A
S
L
E
E
L
Q
S
V
H
S
E
R
----
H
V
-
L
L
Y
G
-
T
N
P
L
S
--------------VMLPCGGVG-------
V
D
T
-------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
---
Q
Q
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
GLD
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
--
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
----
N
L
A
----
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
45.06
46%
-14
- C3 -
-
2VQO
7
HDAC4_HUMAN
A:
[10-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
T
L
M
L
K
H
Q-------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
----
A
T
L
E
E
L
Q
T
V
H
S
E
A
----
H
T
-
L
L
Y
G
-
T
N
P
L
----------------------------------VDS----------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
-----
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
GLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
HP
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
----
G
L
A
----
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
45.00
45%
-22
- C3 -
-
3C0Z
5
HDAC7_HUMAN
B:
[40-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
-
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
----
A
S
L
E
E
L
Q
S
V
H
S
E
R
----
H
V
-
L
L
Y
G
-
T
N
P
L
S
--------------VMLPCGGVG-------
V
D
T
-------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
---
Q
Q
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
GLD
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
--
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
----
N
L
A
----
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
44.92
45%
-22
- C3 -
-
3ZNR
5
HDAC7_HUMAN
A:
[40-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
-
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
----
A
S
L
E
E
L
Q
S
V
H
S
E
R
----
H
V
-
L
L
Y
G
-
T
N
P
L
S
--------------VMLPCGGVG-------
V
D
T
-------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
---
Q
Q
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
GLD
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
--
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
----
N
L
A
----
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
44.75
36%
-116
* C3 *
-
5JI5
6
?
A:
[10-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
G
F
Y
S
H
A
D
C
L
Q
H
-
E
M
G
---
Q
W
-
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
L
----
A
D
E
A
A
L
L
R
V
H
T
K
A
----
H
V
D
Y
L
R
A
-
R
S
P
Q
S
G
-----
Y
------
A
----------------
E
I
D
-------------
P
D
T
S
M
N
P
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
---
E
V
H
K
-
L
E
-
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
P
---
F
Y
P
F
T
G
A
--------
D
N
Q
A
P
N
M
C
N
V
P
I
A
A
----
R
S
K
G
M
V
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
E
--
D
--
D
L
G
N
M
A
L
V
E
D
D
Y
A
W
I
T
Q
Q
I
R
----
L
V
A
D
K
YA
K
G
R
I
V
S
C
L
E
G
G
Y
N
L
S
A
L
G
R
S
V
V
A
H
V
R
A
L
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
44.72
45%
-22
- C3 -
-
3C10
5
HDAC7_HUMAN
B:
[40-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
-
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
----
A
S
L
E
E
L
Q
S
V
H
S
E
R
----
H
V
-
L
L
Y
G
-
T
N
P
L
S
--------------VMLPCGGVG-------
V
D
T
-------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
---
Q
Q
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
GLD
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
--
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
----
N
L
A
----
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
44.44
46%
-30
- C3 -
-
2VQJ
9
A:
[10-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
-
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
----
A
T
L
E
E
L
Q
T
V
H
S
E
A
----
H
T
-
L
L
Y
G
-
T
N
P
L
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
----------------
S
V
F
VRLPCGGVGVDS-
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
-----
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
GLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
HP
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
----
G
L
A
----
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
44.32
46%
-13
- C3 -
-
2VQQ
7
HDAC4_HUMAN
A:
[10-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
T
L
M
L
K
H
Q------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
----
A
T
L
E
E
L
Q
T
V
H
S
E
A
----
H
T
-
L
L
Y
G
-
T
N
P
L
----------------------------------VDS----------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
-----
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
GLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
HP
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
----
G
L
A
----
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NEL
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
43.86
45%
-5
- C3 -
-
3ZNS
5
C:
[40-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
-
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
----
A
S
L
E
E
L
Q
S
V
H
S
E
R
----
H
V
-
L
L
Y
G
-
T
N
P
----------------LPCGGVG---------
V
D
T
-------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
---
Q
Q
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
GLD
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
--
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
----
N
L
A
----
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
43.47
46%
-26
- C3 -
-
4CBT
3
C:
[10-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
-----S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
----
A
T
L
E
E
L
Q
T
V
H
S
E
A
----
H
T
-
L
L
Y
G
-
T
N
P
L
------------------------------------------------
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L--
S
-----
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
GLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
HP
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
----
G
L
A
----
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
NE------
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
43.35
45%
-4
- C3 -
-
3C10
5
C:
[40-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
-
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
----
A
S
L
E
E
L
Q
S
V
H
S
E
R
----
H
V
-
L
L
Y
G
-
T
N
P
----------------LPCGGVG---------
V
D
T
-------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
---
Q
Q
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
GLD
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
--
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
----
N
L
A
----
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
42.24
45%
-7
- C3 -
-
3C0Z
5
C:
[40-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
-
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
----
A
S
L
E
E
L
Q
S
V
H
S
E
R
----
H
V
-
L
L
Y
G
-
T
N
P
----------------LPCGGVG---------
V
D
T
-------------
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
---
Q
Q
S
-
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
GLD
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
--
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
----
N
L
A
----
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
31.22
38%
-0
- C3 -
-
5JI5
6
?
A:
[28-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
E
C
P
A
R
L
Q
A
I
----
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
L
A
D
E
A
A
L
L
R
V
H
T
K
A
----
H
V
D
Y
L
R
A
R
S
P
Q
S
G
Y
A
E
I
D
P
D
------
T
----------------
S
-------------------
M
N
P
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
---
E
V
--
H
K
L
E
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
---
P
F
Y
P
F
--
T
G
A
D
N
Q
----
A
P
N
M
C
N
V
P
I
A
A
R
S
---
K
G
M
V
V
R
E
---
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
E
--
D
--
D
L
G
N
M
A
L
V
E
D
D
Y
A
W
I
T
Q
Q
I
R
L
V
A
D
K
Y
A
----
K
G
R
I
V
S
C
L
E
G
G
Y
N
L
S
A
L
G
R
S
V
V
A
H
V
R
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------