@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HDAC7_HUMAN: (2017-06-15 )
MDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
Atome Classification :
(135 SA)
.........10........20........30........40........50........60........70........80--.........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580....-...590.......600.......610.......620.......630.......640.......650.......660......--.670.......680.......690...-....-700.......710.......720.......730.......740-.--.--.--.--....750.......760.......770.......780.......790.......800.....------..810.......820...-..--.----.830--.........840...--....850.......860---.......870.......880.......890.......900.......910.......920.......930.......940.......950
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDLRVGQRPPVEPPPEP
T
L
L
A
LQ
R
P
Q
R
L
H
H
H
L
F
L
A
G
L
Q
Q
QRSVE
P
M
R
LSMDTPMPELQVGP
Q
E
Q
E
L
R
Q
L
L
H
KDK
S
K
R
S
A
V
---
A
S
S
V
V
K
Q
K
L
A
E
V
I
L
K
K
Q
Q
A
A
L
E
RTVHPNSPGIPYRTLEPLETEG
A
T
R
S
M
L
S
S
FLPPVPSLPSDPPEHFP
L
R
KTVSEP
N
L
K
L
R
YK
P
K
K
S
L
E
R
RKNPLLRKESA
P
P
S
L
RRR
P
A
E
TLGDSSPSSSSTPASGCSSPNDSEHGPNPILG
S
E
A
L
L
G
Q
R
L
R
L
QETSVAPFAL
P
T
V
S
L
L
P
A
I
TLGLPAPARADSDRRTHPTLGPRGPILGSPHT
P
L
F
LPHGLEPEAGGTLPSRL
Q
P
I
L
L
LDPSGSHA
P
L
L
TVPGLGPL
P
F
H
F
A
Q
S
L
M
T
T
ERLSGSGLHWPLSRTRSEPLPPSATAPPPPGP
M
Q
P
R
L
E
Q
L
K
T
H
V
Q
V
I
K
R
SAKPSEKPRLRQIPSAEDLETDGGGPG
Q
V
V
DDGLEHRELGHGQPEARGPAP
L
Q
QHP
Q
V
L
L
W
E
Q
Q
R
L
AGRLPRGSTG
D
T
V
L
L
P
LAQGGHRP
L
S
RAQSSPAAPASLSAPEP
A
S
Q
A
R
VLSSSETPARTLPF
T
T
G
L
I
Y
D
S
V
M
L
K
H
QCSCGDNSRH
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
RG
L
R
S
Q
C
E
C
L
RGRKA
S
L
E
E
L
Q
S
V
H
SE
R
H
V
-
L
L
Y
GTNPL
S
R
L
KLDN
G
K
L
A
G
L
L
A
QR
M
F
V
M
LPCGGVGV
D
T
D
T
I
W
N
E
L
HSSNAARWAAG
S
V
T
D
L
A
F
K
V
A
S
R
E
L
KN
G
F
A
VVRPPG--HHADHSTA
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q-SKA
S
-
K
I
L
I
V
D
W
D
VHHGNGTQQTFYQDP
S
V
L
Y
I
S
L
H
RHDDGNFFPGS--G--A--V--D--EVGAGSGE
G
F
N
V
N
V
A
WAGGLDPPMG
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
EFSP
D
L
V
L
V
SAGFDAAEGHP------APLG
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L----AG
G
A
V
V
L
A
LEGGHDL--
T
A
ICD
A
S
E
A
C
V
A
A
L
LGN---RVDPLSEEGWKQKP
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
A
SC
P
D
S
WVPRVPGA
D
K
E
E
V
E
A
V
T
A
L
A
S
L
S
V
G
I
L
AEDR
P
S
E
Q
L
VEEEEPMNL
1
PsiBlast_PDB
85.47
100%
-113
- C5 -
-
3C0Y
4
HDAC7_HUMAN
A:
[35-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
R
M
F
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
----------------------------------------------------
3
PsiBlast_PDB
85.36
100%
-112
- C5 -
-
3C10
5
HDAC7_HUMAN
A:
[35-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
----------------------------------------------------
2
PsiBlast_PDB
85.28
100%
-112
- C5 -
-
3C0Z
5
HDAC7_HUMAN
A:
[35-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
----------------------------------------------------
22
PsiBlast_CBE
84.94
100%
-113
- C5 -
-
3ZNS
5
HDAC7_HUMAN
B:
[38-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
----------------------------------------------------
24
PsiBlast_CBE
84.93
100%
-110
- C5 -
-
3ZNR
4
HDAC7_HUMAN
B:
[37-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
----------------------------------------------------
4
PsiBlast_PDB
84.55
100%
-111
- C5 -
-
3ZNR
5
HDAC7_HUMAN
A:
[36-421]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
---------------------------------------------------
28
PsiBlast_CBE
84.24
100%
-112
- C5 -
-
3C0Z
5
HDAC7_HUMAN
B:
[36-421]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
---------------------------------------------------
30
PsiBlast_CBE
84.11
100%
-113
- C5 -
-
3C0Y
4
HDAC7_HUMAN
B:
[37-421]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
---------------------------------------------------
5
PsiBlast_PDB
84.03
100%
-115
- C5 -
-
3ZNS
5
HDAC7_HUMAN
A:
[36-421]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
---------------------------------------------------
26
PsiBlast_CBE
83.54
100%
-112
- C5 -
-
3C10
5
HDAC7_HUMAN
B:
[36-421]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
---------------------------------------------------
21
PsiBlast_CBE
83.27
100%
-115
- C5 -
-
3ZNS
5
C:
[39-419]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
-----------------------------------------------------
23
PsiBlast_CBE
82.98
100%
-112
- C5 -
-
3ZNR
4
C:
[39-419]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
-----------------------------------------------------
25
PsiBlast_CBE
82.75
100%
-114
- C5 -
-
3C10
5
C:
[39-419]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
-----------------------------------------------------
29
PsiBlast_CBE
82.21
100%
-113
- C5 -
-
3C0Y
4
C:
[39-419]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
-----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
-----------------------------------------------------
27
PsiBlast_CBE
81.93
100%
-110
- C5 -
-
3C0Z
5
C:
[39-419]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
-
L
L
Y
G
T
N
P
----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
--
G
--
A
--
V
--
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
------
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
-
Q
L
--
M
----
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
---
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
-----------------------------------------------------
11
PsiBlast_PDB
79.89
75%
-113
- C5 -
-
4CBY
5
HDAC4_HUMAN
A:
[9-388]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
-----------------------------------------------------
39
PsiBlast_CBE
79.62
75%
-112
- C5 -
-
4CBY
6
HDAC4_HUMAN
B:
[8-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
------------------------------------------------------
37
PsiBlast_CBE
79.44
75%
-115
- C5 -
-
4CBY
5
D:
[9-389]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
----------------------------------------------------
12
PsiBlast_PDB
79.38
75%
-111
- C5 -
-
5A2S
4
HDAC4_HUMAN
A:
[9-388]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
-----------------------------------------------------
38
PsiBlast_CBE
79.12
75%
-114
- C5 -
-
4CBY
5
HDAC4_HUMAN
C:
[9-388]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
-----------------------------------------------------
36
PsiBlast_CBE
79.09
75%
-112
- C5 -
-
5A2S
4
B:
[9-388]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
-----------------------------------------------------
6
PsiBlast_PDB
78.91
72%
-110
- C5 -
-
2VQJ
9
A:
[8-407]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
N
E
----------------------------------
7
PsiBlast_PDB
78.12
72%
-113
- C5 -
-
2VQM
5
A:
[8-407]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
-------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
N
R
Q
----
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
N
E
----------------------------------
8
PsiBlast_PDB
75.53
71%
-106
- C5 -
-
2VQQ
7
HDAC4_HUMAN
A:
[8-405]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
-----------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
----------------------------
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
------------------------------------
9
PsiBlast_PDB
75.50
71%
-109
- C5 -
-
2VQO
7
HDAC4_HUMAN
A:
[8-405]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
----------------------------
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
------------------------------------
35
PsiBlast_CBE
75.42
71%
-110
- C5 -
-
2VQO
6
B:
[8-405]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
-------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
-----------------------------
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
------------------------------------
33
PsiBlast_CBE
75.31
75%
-110
- C5 -
-
4CBT
3
HDAC4_HUMAN
B:
[8-388]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
-------------------------------
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
-----
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
-----------------------------------------------------
31
PsiBlast_CBE
75.03
71%
-109
- C5 -
-
2VQQ
6
B:
[8-405]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
--------------
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
-----------------------------
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
------------------------------------
34
PsiBlast_CBE
74.88
71%
-113
- C5 -
-
2VQV
8
B:
[8-405]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
-------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
-------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
------------------------------------
10
PsiBlast_PDB
74.75
71%
-113
- C5 -
-
2VQV
6
HDAC4_HUMAN
A:
[8-405]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
--------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
--------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
------------------------------------
32
PsiBlast_CBE
73.81
75%
-114
- C5 -
-
4CBT
3
C:
[8-389]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
----
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
-
L
L
Y
G
T
N
P
L
--------------------------------
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
--
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
--
G
--
A
--
P
--
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
------
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
-
Q
L
--
M
----
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
--
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
---
E
------
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
----------------------------------------------------
20
PsiBlast_PDB
63.89
43%
-56
- C5 -
-
5EF7
4
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
D
H
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
48
PsiBlast_CBE
63.74
43%
-55
- C5 -
-
5EF8
6
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
D
H
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
231
HHSearch
63.07
45%
-54
- C5 -
-
5G0H
14
?
A:
[404-763]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
----
R
D
L
--------------
N
R
L
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
--
E
--
D
AN
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--------
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
---
S
P
P
S
L
D
H
L
---
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
V
N
---------------------------------------------------
55
PsiBlast_CBE
63.07
42%
-55
- C5 -
-
5EFN
5
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
D
H
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
18
PsiBlast_PDB
63.03
43%
-55
- C5 -
-
5EEM
5
?
B:
[10-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
---
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
------------------------------------------------------
47
PsiBlast_CBE
63.01
43%
-53
- C5 -
-
5EF8
7
?
B:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
D
H
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
49
PsiBlast_CBE
62.78
43%
-55
- C5 -
-
5EF7
5
?
B:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
D
--
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
46
PsiBlast_CBE
62.77
43%
-55
- C5 -
-
5EFB
4
?
D:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
--
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
14
PsiBlast_PDB
62.77
43%
-55
- C5 -
-
5G0H
14
?
A:
[407-761]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--------
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
D
H
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
50
PsiBlast_CBE
62.63
43%
-52
- C5 -
-
5EEN
5
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
D
H
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
53
PsiBlast_CBE
62.52
43%
-53
- C5 -
-
5EFK
8
?
B:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
F
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
-
H
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
15
PsiBlast_PDB
62.49
43%
-49
- C5 -
-
5G0J
5
?
A:
[407-761]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--------
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
D
H
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
17
PsiBlast_PDB
62.43
43%
-57
- C5 -
-
5EEK
30
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
--
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
43
PsiBlast_CBE
62.42
43%
-55
- C5 -
-
5EFH
9
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
D
H
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
19
PsiBlast_PDB
62.40
43%
-55
- C5 -
-
5EEN
4
?
B:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
----------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
54
PsiBlast_CBE
62.20
42%
-56
- C5 -
-
5EFN
6
?
B:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
D
H
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
232
HHSearch
62.12
37%
-62
- C5 -
-
5G0G
9
?
A:
[21-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
--
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
-
E
L
M
K
S
T
Q
N
M
T
E
----
E
E
L
------
K
T
L
----
A
---
E
K
Y
D
S
V
Y
L
H
-
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
--
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
--
K
ES
D
--
S
--
S
--
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
---
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
--------
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
-
M
L
--
K
----
G
V
----
A
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
--
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
---
P
C
P
H
L
P
S
S
---
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
F
---------------------------------------------------
60
PsiBlast_CBE
61.71
35%
-44
- C5 -
-
5EEF
7
?
A:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
V
D
A
F
T
R
F
H
-------
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
------
L
A
E
K
Y
-------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
--
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
--
K
--
E
--
S
--
D
SS
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
------
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
-
M
L
--
K
----
G
V
----
A
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
--
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
---
P
C
P
H
L
P
S
S
G
---
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
----------------------------------------------------
42
PsiBlast_CBE
61.53
43%
-53
- C5 -
-
5EFH
7
?
D:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
-
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
P
R
-
D
L
N
R
L
-----------------
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
ED
A
--
N
--
Y
--
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--------
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
SPP
S
L
D
H
L
T
------
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------------------------------------------------
58
PsiBlast_CBE
61.09
35%
-44
- C5 -
-
5G0G
9
?
A:
[25-380]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
--
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
------
L
A
E
K
Y
-------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
--
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
--
K
--
E
--
S
--
D
SS
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
------
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
-
M
L
--
K
----
G
V
----
A
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
--
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
---
P
C
P
H
L
P
S
S
G
---
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
F
---------------------------------------------------
59
PsiBlast_CBE
61.00
35%
-43
- C5 -
-
5EEF
6
?
B:
[10-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
--
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
------
L
A
E
K
Y
-------------
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
--
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
--
K
--
E
--
S
--
D
SS
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
------
K
--
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
-
M
L
--
K
----
G
V
----
A
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
--
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
---
P
C
P
H
L
P
S
S
G
---
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
----------------------------------------------------
251
Fugue
58.33
31%
6
- C5 -
-
5G0J
9
?
A:
[17-772]
----------
V
Q
G
K
S
K
A
T
G
---------------
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
A
S
H
P
E
C
P
--
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
------------------
M
T
E
E
E
L
K
T
L
A
E
K
Y
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
-
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
----
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
--------------------
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
------
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
V
G
M
--
E
S
G
D
Y
I
T
A
F
Q
Q
-----
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
--------------
D
A
V
I
G
D
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
Q
--------------------
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
P
C
P
H
--------
L
P
S
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
F
E
G
G
P
L
S
E
V
S
P
L
P
A
P
V
C
A
E
V
K
V
S
S
P
I
-------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
--
W
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
----
H
M
K
P
R
D
L
N
R
L
G
D
E
Y
--------------
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
--
E
--
D
--
A
NY
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
--------
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
-
Q
L
--
M
----
S
L
----
A
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
--
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
---
S
P
P
S
L
D
H
L
---
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
-------------------------------
S
L
R
V
N
I
P
E
S
L
R
L
S
L
-----------
240
HHSearch
56.92
35%
-110
- C5 -
-
5JI5
6
?
A:
[10-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
G
F
Y
S
H
A
D
C
L
Q
H
E
M
----
G
Q
W
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
L
A
D
E
A
A
L
L
R
V
H
T
K
A
H
V
-
D
Y
L
R
A
R
S
P
Q
S
----------------------
G
Y
A
E
I
D
P
D
T
S
M
N
-
P
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
--
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
V
-
H
K
L
E
-
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
---
P
F
Y
P
F
T
--
G
--
A
--
D
--
N
--------
Q
A
P
N
M
C
N
V
P
I
A
A
R
----
S
K
G
M
V
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
E
D
--------
D
L
G
N
M
A
L
V
E
D
D
Y
A
W
I
T
Q
-
Q
I
--
R
----
L
V
A
D
K
Y
A
K
G
R
I
V
S
C
L
E
G
G
Y
N
L
--
S
A
L
G
R
S
V
V
A
H
V
R
A
L
A
D
----------------------------------------------------------------------------------------------
81
PsiBlast_CBE
49.29
33%
-40
- C5 -
-
5JI5
6
?
A:
[28-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
L
A
D
E
A
A
L
L
R
V
H
T
K
A
H
V
D
Y
L
R
A
R
S
P
Q
S
-----------------------
G
Y
A
E
I
D
P
D
T
S
M
N
P
-
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
--
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
V
-
H
K
L
E
-
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
P
---
F
Y
P
F
T
--
G
--
A
--
D
--
N
--
Q
----
A
P
N
M
C
N
V
P
I
A
---
A
R
S
K
G
M
V
V
R
E
---
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
--
E
------
D
D
L
G
N
M
A
L
V
E
D
D
Y
A
W
I
T
Q
-
Q
I
--
R
L
V
A
D
K
Y
----
A
K
G
R
I
V
S
C
L
E
G
G
Y
N
L
--
S
A
L
G
R
S
V
V
A
H
V
R
A
L
------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
45.91
31%
-94
- C5 -
-
4QA3
7
HDAC8_HUMAN
A:
[142-327]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
--
A
N
M
A
R
C
W
T
Y
L
T
G
V
I
L
G
K
---
T
L
----------------------------------------------------------------------------------------
159
PsiBlast_CBE
45.25
34%
-109
- C5 -
-
5DC7
4
HDAC8_HUMAN
B:
[142-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
A
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
----
I
L
----
G
G
G
G
F
N
L
A
-----------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
45.20
35%
-108
- C5 -
-
4QA5
7
HDAC8_HUMAN
B:
[142-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
T
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
----
I
L
----
G
G
G
G
F
N
L
A
-----------------------------------------------------------------------------------------------------------------------
160
PsiBlast_CBE
44.94
34%
-110
- C5 -
-
5DC7
3
HDAC8_HUMAN
A:
[142-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
A
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
----
I
L
----
G
G
G
G
F
N
L
A
-----------------------------------------------------------------------------------------------------------------------
145
PsiBlast_CBE
44.89
34%
-105
- C5 -
-
2V5W
6
HDAC8_HUMAN
B:
[142-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
----
I
L
----
G
G
G
G
F
N
L
A
-----------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
44.89
31%
-91
- C5 -
-
4QA3
5
HDAC8_HUMAN
B:
[142-327]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
--
A
N
M
A
R
C
W
T
Y
L
T
G
V
I
L
G
K
---
T
L
----------------------------------------------------------------------------------------
126
PsiBlast_CBE
44.77
34%
-92
- C5 -
-
3SFH
6
HDAC8_HUMAN
A:
[143-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
146
PsiBlast_CBE
44.52
34%
-107
- C5 -
-
2V5W
5
HDAC8_HUMAN
A:
[142-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
----
I
L
----
G
G
G
G
F
N
L
A
-----------------------------------------------------------------------------------------------------------------------
151
PsiBlast_CBE
44.46
34%
-110
- C5 -
-
5DC6
4
HDAC8_HUMAN
B:
[142-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
N
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
AT
L
----
I
L
----
G
G
G
G
F
N
L
A
-----------------------------------------------------------------------------------------------------------------------
129
PsiBlast_CBE
44.45
34%
-91
- C5 -
-
4RN2
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
152
PsiBlast_CBE
44.40
34%
-113
- C5 -
-
5DC6
3
HDAC8_HUMAN
A:
[142-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
N
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
----
I
L
----
G
G
G
G
F
N
L
A
-----------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
44.26
35%
-102
- C5 -
-
4QA5
7
HDAC8_HUMAN
A:
[142-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
T
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
----
I
L
----
G
G
G
G
F
N
L
A
-----------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
44.11
34%
-95
- C5 -
-
3EW8
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
134
PsiBlast_CBE
44.10
34%
-107
- C5 -
-
4QA7
6
HDAC8_HUMAN
A:
[142-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
----
I
L
----
G
G
G
G
F
N
L
A
-----------------------------------------------------------------------------------------------------------------------
154
PsiBlast_CBE
44.03
34%
-110
- C5 -
-
5DC8
4
HDAC8_HUMAN
A:
[143-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
----
I
L
----
G
G
G
G
F
N
L
A
-----------------------------------------------------------------------------------------------------------------------
130
PsiBlast_CBE
43.96
34%
-92
- C5 -
-
4RN1
6
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
43.77
34%
-91
- C5 -
-
3F0R
5
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
147
PsiBlast_CBE
43.65
34%
-104
- C5 -
-
4QA6
8
HDAC8_HUMAN
B:
[142-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
N
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
AT
L
----
I
L
----
G
G
G
G
F
N
L
A
-----------------------------------------------------------------------------------------------------------------------
117
PsiBlast_CBE
43.60
34%
-94
- C5 -
-
2V5X
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
43.60
34%
-94
- C5 -
-
3EZT
6
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
AN
T
A
R
C
----------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
43.59
34%
-93
- C5 -
-
5D1B
5
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
120
PsiBlast_CBE
43.57
34%
-93
- C5 -
-
3RQD
5
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
121
PsiBlast_CBE
43.48
34%
-95
- C5 -
-
3RQD
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
127
PsiBlast_CBE
43.43
34%
-96
- C5 -
-
3SFF
4
HDAC8_HUMAN
A:
[143-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
142
PsiBlast_CBE
43.38
34%
-91
- C5 -
-
1T67
4
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCS
F
N
M
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
141
PsiBlast_CBE
43.37
34%
-93
- C5 -
-
1T69
2
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MC
S
F
N
M
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
148
PsiBlast_CBE
43.32
34%
-103
- C5 -
-
4QA6
8
HDAC8_HUMAN
A:
[142-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
N
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
A
T
L
----
I
L
----
G
G
G
G
F
N
L
A
-----------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
43.30
34%
-95
- C5 -
-
3F06
4
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MC
S
F
N
M
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
112
PsiBlast_CBE
43.29
34%
-91
- C5 -
-
3F0R
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
43.26
34%
-92
- C5 -
-
3F0R
5
HDAC8_HUMAN
C:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCS
F
N
M
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
43.25
34%
-92
- C5 -
-
3MZ4
5
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
132
PsiBlast_CBE
43.18
34%
-95
- C5 -
-
4RN0
6
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
137
PsiBlast_CBE
43.14
34%
-93
- C5 -
-
1W22
5
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
43.13
34%
-95
- C5 -
-
3F06
4
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
AN
T
A
R
C
----------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
43.11
34%
-95
- C5 -
-
3EZT
6
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MC
S
F
N
M
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
43.02
34%
-93
- C5 -
-
4QA4
7
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
125
PsiBlast_CBE
42.97
34%
-97
- C5 -
-
5BWZ
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
164
PsiBlast_CBE
42.95
33%
-89
- C5 -
-
4QA0
6
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
F
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
AN
T
A
R
C
----------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
42.95
34%
-95
- C5 -
-
3MZ7
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
128
PsiBlast_CBE
42.91
34%
-92
- C5 -
-
4RN2
5
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
42.90
34%
-95
- C5 -
-
3MZ6
4
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
42.90
34%
-95
- C5 -
-
3EZP
6
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
AN
T
A
R
C
----------------------------------------------------------------------------------------------------------
118
PsiBlast_CBE
42.86
34%
-97
- C5 -
-
5FCW
7
?
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
136
PsiBlast_CBE
42.85
34%
-91
- C5 -
-
4QA2
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
N
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
144
PsiBlast_CBE
42.82
34%
-93
- C5 -
-
1T64
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
119
PsiBlast_CBE
42.74
34%
-95
- C5 -
-
5FCW
7
?
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
138
PsiBlast_CBE
42.71
34%
-92
- C5 -
-
1W22
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
42.71
34%
-88
- C5 -
-
5D1B
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
143
PsiBlast_CBE
42.67
34%
-94
- C5 -
-
1T64
5
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
AN
T
A
R
C
----------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
42.63
34%
-93
- C5 -
-
3MZ4
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
155
PsiBlast_CBE
42.59
33%
-92
- C5 -
-
3EWF
7
HDAC8_HUMAN
D:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
AN
T
A
R
C
----------------------------------------------------------------------------------------------------------
158
PsiBlast_CBE
42.57
33%
-91
- C5 -
-
3EWF
8
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
156
PsiBlast_CBE
42.57
33%
-92
- C5 -
-
3EWF
8
HDAC8_HUMAN
C:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
AN
T
A
R
C
----------------------------------------------------------------------------------------------------------
157
PsiBlast_CBE
42.49
33%
-90
- C5 -
-
3EWF
7
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
AN
T
A
R
C
----------------------------------------------------------------------------------------------------------
123
PsiBlast_CBE
42.42
34%
-95
- C5 -
-
3MZ3
5
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MC
S
F
N
M
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
135
PsiBlast_CBE
42.40
34%
-90
- C5 -
-
4QA2
7
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
N
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
42.40
34%
-96
- C5 -
-
3EZP
6
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MC
S
F
N
M
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
124
PsiBlast_CBE
42.38
34%
-92
- C5 -
-
5BWZ
6
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
133
PsiBlast_CBE
42.36
34%
-94
- C5 -
-
4RN0
7
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
131
PsiBlast_CBE
42.24
34%
-91
- C5 -
-
4RN1
7
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
116
PsiBlast_CBE
42.01
34%
-93
- C5 -
-
2V5X
5
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MC
S
F
N
M
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
165
PsiBlast_CBE
41.93
33%
-89
- C5 -
-
4QA0
6
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
F
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
150
PsiBlast_CBE
41.89
33%
-89
- C5 -
-
5DC5
4
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
N
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
122
PsiBlast_CBE
41.82
34%
-94
- C5 -
-
3MZ3
5
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MC
S
F
N
M
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
115
PsiBlast_CBE
41.65
34%
-94
- C5 -
-
3F07
4
HDAC8_HUMAN
A:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
114
PsiBlast_CBE
41.56
34%
-93
- C5 -
-
3F07
4
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
149
PsiBlast_CBE
41.39
33%
-87
- C5 -
-
5DC5
4
HDAC8_HUMAN
B:
[142-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---
K
F
E
-
R
I
L
Y
V
N
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
-
F
F
P
G
T
--
G
--
D
--
V
--
S
--
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
I
Q
----
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
MCSFNM
T
P
V
G
----
I
G
K
C
L
K
Y
I
L
Q
W
Q
L
--
A
----
T
L
----
I
L
G
G
------
G
G
Y
N
L
A
N
T
A
R
C
----------------------------------------------------------------------------------------------------------
162
PsiBlast_CBE
33.41
33%
-20
- C5 -
-
1C3R
3
?
B:
[113-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
E
E
F
L
K
G
N
V
A
F
N
P
A
G
GM
H
H
A
F
K
S
R
A
N
G
F
C
Y
I
N
N
P
A
V
G
I
E
Y
L
R
K
K
-
G
-
F
K
-
R
I
L
Y
I
D
L
D
A
H
H
C
D
G
V
Q
E
A
F
Y
D
T
D
Q
V
F
V
L
S
L
H
Q
S
P
E
Y
A
F
P
F
E
K
--
G
--
F
--
L
--
E
--
E
I
G
E
G
K
G
K
G
Y
N
L
N
I
P
L
P
K
G
L
N
----
D
N
E
F
L
F
A
L
E
K
S
L
E
I
V
K
E
V
F
E
P
E
V
Y
L
L
Q
L
G
T
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
PsiBlast_CBE
33.39
33%
-18
- C5 -
-
1C3R
3
?
A:
[113-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
E
E
F
L
K
G
N
V
A
F
N
P
A
G
GM
H
H
A
F
K
S
R
A
N
G
F
C
Y
I
N
N
P
A
V
G
I
E
Y
L
R
K
K
-
G
-
F
K
-
R
I
L
Y
I
D
L
D
A
H
H
C
D
G
V
Q
E
A
F
Y
D
T
D
Q
V
F
V
L
S
L
H
Q
S
P
E
Y
A
F
P
F
E
K
--
G
--
F
--
L
--
E
--
E
I
G
E
G
K
G
K
G
Y
N
L
N
I
P
L
P
K
G
L
N
----
D
N
E
F
L
F
A
L
E
K
S
L
E
I
V
K
E
V
F
E
P
E
V
Y
L
L
Q
L
G
T
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
PsiBlast_CBE
32.56
33%
-10
- C5 -
-
1C3S
2
?
A:
[113-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
E
E
F
L
K
G
N
V
A
F
N
P
A
G
GM
H
H
A
F
K
S
R
A
N
G
F
C
Y
I
N
N
P
A
V
G
I
E
Y
L
R
K
K
-
G
-
F
K
-
R
I
L
Y
I
D
L
D
A
H
H
C
D
G
V
Q
E
A
F
Y
D
T
D
Q
V
F
V
L
S
L
H
Q
S
P
E
Y
A
F
P
F
E
K
--
G
--
F
--
L
--
E
--
E
I
G
E
G
K
G
K
G
Y
N
L
N
I
P
L
P
K
G
L
N
----
D
N
E
F
L
F
A
L
E
K
S
L
E
I
V
K
E
V
F
E
P
E
V
Y
L
L
Q
L
G
T
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
PsiBlast_CBE
27.74
44%
-47
- C5 -
-
4ZUP
7
APHA_MYCRA
A:
[147-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
F
S
L
C
R
P
P
G
--
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
-
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
--
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
PsiBlast_CBE
27.16
44%
-50
- C5 -
-
4ZUP
5
APHA_MYCRA
B:
[147-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
F
S
L
C
R
P
P
G
--
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
-
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
--
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
PsiBlast_CBE
27.00
44%
-50
- C5 -
-
4ZUM
5
APHA_MYCRA
B:
[147-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
F
S
L
C
R
P
P
G
--
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
-
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
--
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
PsiBlast_CBE
26.62
44%
-49
- C5 -
-
4ZUO
5
APHA_MYCRA
A:
[147-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
F
S
L
C
R
P
P
G
--
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
-
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
--
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
PsiBlast_CBE
26.56
44%
-45
- C5 -
-
4ZUN
5
APHA_MYCRA
A:
[147-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
F
S
L
C
R
P
P
G
--
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
-
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
--
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
PsiBlast_CBE
26.56
44%
-48
- C5 -
-
4ZUQ
5
APHA_MYCRA
B:
[147-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
F
S
L
C
R
P
P
G
--
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
-
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
--
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
PsiBlast_CBE
26.53
44%
-47
- C5 -
-
4ZUM
6
APHA_MYCRA
A:
[147-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
F
S
L
C
R
P
P
G
--
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
-
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
--
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
PsiBlast_CBE
26.50
44%
-48
- C5 -
-
4ZUQ
5
APHA_MYCRA
A:
[147-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
F
S
L
C
R
P
P
G
--
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
-
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
--
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
PsiBlast_CBE
26.30
44%
-48
- C5 -
-
4ZUO
6
APHA_MYCRA
B:
[147-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
F
S
L
C
R
P
P
G
--
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
-
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
--
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
PsiBlast_CBE
26.25
44%
-47
- C5 -
-
4ZUN
4
APHA_MYCRA
B:
[147-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
F
S
L
C
R
P
P
G
--
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
-
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
H
F
L-
G
--
Y
--
A
--
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------