@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HDAC9_HUMAN: (2017-06-15 )
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLKFS
Atome Classification :
(61 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630---........640.......650.......660.......670.......680.......690...-...-.700.......710.....--..720.......730.......740.......750.......760.......770.......780.......790.......800......-.810-.......820.......830.......840.......850--..-.--.--..--.860.......870.......880....----...890.......900.......910.......920.......930.......940.----..----..-..950.......960.......970.......980.......-990.......1000......1010
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MH
S
M
I
SSVDVKSEVPVGLEPISP
L
D
L
R
T
D
L
R
M
M
M
P
VV
D
P
V
V
R
E
K
Q
L
Q
Q
E
L
L
L
I
Q
Q
Q
Q
Q
I
Q
K
Q
L
L
I
A
E
F
Q
K
Q
H
E
N
L
T
R
Q
H
Q
A
Q
L
Q
E
H
I
K
E
L
L
A
I
K
Q
Q
Q
E
L
L
E
K
E
Q
K
L
E
Q
Q
R
Q
E
Q
E
V
E
R
H
R
R
E
QQLPPLRGKDRGRERA
V
A
S
T
E
V
K
Q
K
L
Q
E
F
L
L
SKSATKDTPTNGKNHSVSRHP
K
L
W
Y
T
AAHHTSLDQSSPPLSGTSP
S
Y
K
Y
TLPGAQDAKDDFPLRKTASEP
N
L
K
V
R
S
R
L
K
Q
K
V
A
E
R
RSSPLLRRKDG
N
V
V
T
S
F
K
K
R
M
F
E
V
T
E
SSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTP
H
A
E
Q
M
V
S
QQ
R
I
L
I
HEDS
M
N
L
L
S
L
YTSPSLP
N
I
T
LGLPAVPSQLNASNS
L
K
E
K
Q
K
C
E
T
Q
T
L
RQGVPLPGQYGGSIPASSSH
P
H
V
T
L
EGKPPN
S
S
H
Q
A
L
L
Q
H
L
L
L
K
E
Q
M
R
Q
Q
K
L
L
VAGGVPLHPQSPLA
T
K
E
RISPGIRGTHKLPRHRPLNRTQSAPL
P
Q
S
T
L
A
Q
L
V
I
Q
Q
Q
H
Q
Q
F
L
E
K
Q
K
Q
Y
Q
Q
Q
I
H
M
N
K
L
L
S
K
S
I
E
Q
L
KQPG
S
H
L
E
E
A
E
E
E
LQG
D
Q
A
M
Q
EDRAPSSGNSTRSDSSA
C
V
D
D
TLGQV
G
A
V
K
V
KEEPVDSDED
A
Q
I
Q
E
M
ESGE
Q
A
A
F
M
QQPFLEPTH
T
R
A
L
SVRQA
P
L
A
A
V
G
M
D
G
L
E
K
H
R
L
V
SRTHSSP
A
A
SVLPHPAMDRPLQPGS----ATGIAYDPL
M
L
K
H
QCVCGNSTTH
P
E
HA
G
R
I
Q
S
I
W
S
R
L
Q
ETG
L
L
N
K
C
E
R
I
QGRKA
S
L
E
E
I
Q
L
V
H
S-EHH-
S
L
L
YGTNPLDGQKLD
P
R
I
L
--LGD
D
S
Q
K
F
F
S
SLPCGGLGVD
S
D
T
I
W
N
E
L
H
SSG
A
A
R
M
A
V
G
C
V
I
E
L
A
S
K
VASGELKN
G
F
A
VVRPPGHHAEEST
A
M
G
F
C
F
FN
S
V
A
I
T
A
K
Y
L
R
D
Q-LN
I
S
-
K
I
L
I
V
D
L
D
V
HHGNGT
Q
Q
A
F
YADP
S
I
L
Y
I
S
L
H
RYDEGNFFP--GS-G--A--P
N
--
E
V
GTGLGE
G
Y
N
I
N
I
A
W
TGGLDPPMG
D
V
E
----
Y
L
E
A
F
R
T
I
V
K
P
V
A
K
EFDP
D
M
V
L
V
SAGFDALEGHTPPLG
G
Y
K
V
T
A
K
C
F
G
H
L
T
K
Q
L
M
T
L----AD----
G
R
-
V
V
L
A
L
EGGHD
L
T
A
IC
D
A
S
E
A
C
V
N
A
L
LGN
E
L
E
P
L
A
E
D
I
L
HQSP-N
M
N
A
V
I
S
L
Q
K
I
I
E
I
Q
S
M
S
LKFS
25
PsiBlast_CBE
82.44
74%
-112
- C6 -
-
4CBY
5
D:
[9-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
--
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
27
PsiBlast_CBE
82.33
74%
-109
- C6 -
-
4CBY
6
HDAC4_HUMAN
B:
[8-381]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
----
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
--
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
4
PsiBlast_PDB
82.03
74%
-111
- C6 -
-
4CBY
5
HDAC4_HUMAN
A:
[9-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
--
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
26
PsiBlast_CBE
81.99
74%
-111
- C6 -
-
4CBY
5
HDAC4_HUMAN
C:
[9-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
--
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
5
PsiBlast_PDB
81.35
74%
-109
- C6 -
-
5A2S
4
HDAC4_HUMAN
A:
[9-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
--
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
24
PsiBlast_CBE
81.13
74%
-110
- C6 -
-
5A2S
4
B:
[9-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
A
N
R
Q
K
L
D
S
K
K
L
--
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
1
PsiBlast_PDB
80.74
74%
-109
- C6 -
-
2VQJ
9
A:
[6-381]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
F
----
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
L
N
R
Q
K
L
D
S
K
K
L
--
L
G
S
L
A
-
S
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
2
PsiBlast_PDB
78.79
74%
-112
- C6 -
-
2VQM
5
A:
[6-381]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
F
----
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
-------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
L
N
R
Q
----
K
K
L
--
L
G
S
L
A
-
S
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
36
PsiBlast_CBE
78.14
67%
-106
- C6 -
-
3C0Z
5
C:
[39-412]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
-
V
L
L
Y
G
T
N
P
------------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
V
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
----
G
A
-
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
------
30
PsiBlast_CBE
78.07
67%
-111
- C6 -
-
3ZNS
5
C:
[39-412]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
-
V
L
L
Y
G
T
N
P
------------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
V
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
----
G
A
-
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
------
22
PsiBlast_CBE
77.82
74%
-104
- C6 -
-
4CBT
3
HDAC4_HUMAN
B:
[5-381]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
R
F
----
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
---------------------------------
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
--
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
34
PsiBlast_CBE
77.67
67%
-110
- C6 -
-
3C10
5
C:
[39-412]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
-
V
L
L
Y
G
T
N
P
------------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
V
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
----
G
A
-
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
------
29
PsiBlast_CBE
77.66
73%
-111
- C6 -
-
2VQO
6
B:
[7-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
----
T
T
G
L
V
Y
D
T
L
M
L
K
-------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
L
-------------------------------
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
32
PsiBlast_CBE
77.61
67%
-108
- C6 -
-
3ZNR
4
C:
[39-412]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
-
V
L
L
Y
G
T
N
P
------------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
V
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
----
G
A
-
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
------
3
PsiBlast_PDB
77.36
74%
-106
- C6 -
-
2VQQ
7
HDAC4_HUMAN
A:
[7-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
----
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
-----------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
L
------------------------------
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
38
PsiBlast_CBE
77.32
67%
-108
- C6 -
-
3C0Y
4
C:
[39-412]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
-
V
L
L
Y
G
T
N
-------------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
V
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
----
G
A
-
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
------
6
PsiBlast_PDB
77.14
73%
-110
- C6 -
-
2VQO
7
HDAC4_HUMAN
A:
[7-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
----
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
L
------------------------------
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
23
PsiBlast_CBE
77.03
74%
-110
- C6 -
-
2VQQ
6
B:
[7-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
----
T
T
G
L
V
Y
D
T
L
M
L
K
H
--------------
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
L
-------------------------------
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
28
PsiBlast_CBE
76.88
73%
-112
- C6 -
-
2VQV
8
B:
[7-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
----
T
T
G
L
V
Y
D
T
L
M
L
K
-------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
L
---------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
21
PsiBlast_CBE
76.67
74%
-108
- C6 -
-
4CBT
3
C:
[5-381]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
R
F
----
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
----
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
L
----------------------------------
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
--
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
------
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
7
PsiBlast_PDB
75.92
73%
-112
- C6 -
-
2VQV
6
HDAC4_HUMAN
A:
[7-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
----
T
T
G
L
V
Y
D
T
L
M
L
K
--------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
-
E
A
H
-
T
L
L
Y
G
T
N
P
----------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
S
V
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
P
D
--
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
----
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
----
G
R
-
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
-
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
------
31
PsiBlast_CBE
75.62
67%
-29
- C6 -
-
3ZNS
5
HDAC7_HUMAN
B:
[38-412]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F---
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
-
V
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
--
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
V
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
----
G
A
-
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
------
10
PsiBlast_PDB
74.71
67%
-7
- C6 -
-
3C10
5
HDAC7_HUMAN
A:
[35-412]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLPF
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
-
V
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
--
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
V
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
----
G
A
-
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
------
9
PsiBlast_PDB
74.01
67%
-6
- C6 -
-
3C0Z
5
HDAC7_HUMAN
A:
[35-412]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLPF
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
-
V
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
--
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
V
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
----
G
A
-
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
------
11
PsiBlast_PDB
72.92
67%
-10
- C6 -
-
3ZNR
5
HDAC7_HUMAN
A:
[36-412]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPF-
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
-
V
L
L
Y
G
T
N
P
L
S
--------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
V
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
----
G
A
-
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
------
35
PsiBlast_CBE
72.57
67%
-12
- C6 -
-
3C10
5
HDAC7_HUMAN
B:
[36-412]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPF-
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
-
V
L
L
Y
G
T
N
P
L
S
--------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
V
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
----
G
A
-
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
------
37
PsiBlast_CBE
72.38
67%
-12
- C6 -
-
3C0Z
5
HDAC7_HUMAN
B:
[36-412]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPF-
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
-
V
L
L
Y
G
T
N
P
L
S
--------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
V
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
----
G
A
-
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
------
12
PsiBlast_PDB
72.31
67%
-11
- C6 -
-
3ZNS
5
HDAC7_HUMAN
A:
[36-412]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPF-
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
-
E
R
H
-
V
L
L
Y
G
T
N
P
L
S
--------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
-
S
K
A
S
-
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
--
G
S
-
G
--
A
--
V
D
--
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
----
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
----
G
A
-
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
-
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
------
149
HHSearch
64.70
37%
-62
- C6 -
-
5G0G
9
?
A:
[22-377]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
----
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
--
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
-
K
E
Y
-
V
E
L
M
K
S
T
Q
N
M
T
E
E
----
E
L
--------
K
T
L
----
A
---
E
K
Y
D
S
V
Y
L
H
P
-
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
--
H
L
-
K
ES
D
--
S
S
--
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
---
V
G
M
E
S
G
D
----
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
--
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
----
A
Q
----
G
R
-
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
P
C
P
H
L
P
S
S
---
G
A
P
-
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
Y
P
F
W
K
S
L
150
HHSearch
64.15
44%
-52
- C6 -
-
5G0H
14
?
A:
[404-760]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
----
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
--
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
E
H
M
K
P
----
R
D
L
----------------
N
R
L
G
D
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
-
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
AN
Y
D
--
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
---
T
P
L
-
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
14
PsiBlast_PDB
63.89
43%
-32
- C6 -
-
5G0J
5
?
A:
[389-750]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
L
P
A
P
V
C
A
E
V
K
V
S
S
P
----
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
--
S
P
P
S
L
D
--
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
----------
13
PsiBlast_PDB
62.68
43%
-28
- C6 -
-
5G0H
14
?
A:
[404-750]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
----
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
--
S
P
P
S
L
D
--
H
L
T
P
L
K
T
S
A
T
V
S
I
N
N
V
L
----------
58
PsiBlast_CBE
61.40
36%
-45
* C6 *
-
5EEF
6
?
A:
[8-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
-------
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
-
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
---------------------
L
A
E
K
Y
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
HL
K
E
-
S
--
D
--
S
S
--
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
----
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
--
D
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
----
A
Q
----
G
R
-
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
-------------------------------------
51
PsiBlast_CBE
60.93
46%
-29
- C6 -
-
5EFK
8
?
B:
[10-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
F
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
19
PsiBlast_PDB
60.92
46%
-29
- C6 -
-
5EF7
4
?
A:
[10-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
16
PsiBlast_PDB
60.76
46%
-28
- C6 -
-
5EEK
29
?
A:
[10-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
18
PsiBlast_PDB
60.74
46%
-29
- C6 -
-
5EEN
4
?
B:
[10-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
NR
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
47
PsiBlast_CBE
60.70
46%
-27
- C6 -
-
5EF7
4
?
B:
[10-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
NR
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
45
PsiBlast_CBE
60.63
46%
-29
- C6 -
-
5EFB
4
?
D:
[10-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
NR
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
20
PsiBlast_PDB
60.55
46%
-27
- C6 -
-
5EF8
5
?
A:
[10-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
46
PsiBlast_CBE
60.53
46%
-30
- C6 -
-
5EF8
7
?
B:
[10-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
NR
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
56
PsiBlast_CBE
60.43
36%
-44
- C6 -
-
5G0G
8
?
A:
[23-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
--
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
-
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
---------------------
L
A
E
K
Y
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
HL
K
E
-
S
--
D
--
S
S
--
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
----
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
--
D
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
----
A
Q
----
G
R
-
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
-------------------------------------
42
PsiBlast_CBE
60.21
46%
-29
- C6 -
-
5EFH
9
?
A:
[10-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
17
PsiBlast_PDB
60.18
46%
-29
- C6 -
-
5EEM
5
?
B:
[10-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
NR
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
48
PsiBlast_CBE
60.16
46%
-31
- C6 -
-
5EEN
5
?
A:
[10-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
53
PsiBlast_CBE
60.00
45%
-29
- C6 -
-
5EFN
5
?
A:
[10-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
N
R
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
158
HHSearch
59.95
35%
-109
- C6 -
-
5JI5
6
?
A:
[10-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
G
F
Y
S
H
A
D
C
L
Q
H
E
M
----
G
Q
W
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
L
A
D
E
A
A
L
L
R
V
H
T
-
K
A
H
-
V
D
Y
L
R
A
R
S
P
Q
S
------------------------
G
Y
A
E
I
D
P
D
T
S
M
N
P
-
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
V
-
H
K
L
E
-
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
---
P
F
Y
P
--
F
T
-
G
--
A
--
D
N
--------
Q
A
P
N
M
C
N
V
P
I
A
A
R
----
S
K
G
M
V
----
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
E
D
--
D
L
G
N
M
A
L
V
E
D
D
Y
A
W
I
T
Q
Q
I
R
L
V
A
D
K
Y
A
K
----
G
R
-
I
V
S
C
L
E
G
G
Y
N
L
S
A
L
G
R
S
V
V
A
H
V
R
A
L
A
D
--------------------------------------
57
PsiBlast_CBE
59.95
36%
-43
- C6 -
-
5EEF
6
?
B:
[8-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
--
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
-
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
---------------------
L
A
E
K
Y
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
-
H
R
V
Q
-
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
HL
K
E
-
S
--
D
--
S
S
--
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
---
K
V
G
M
E
S
G
D
----
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
--
D
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
----
A
Q
----
G
R
-
L
V
L
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
-------------------------------------
52
PsiBlast_CBE
59.76
45%
-28
- C6 -
-
5EFN
6
?
B:
[10-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
NR
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
41
PsiBlast_CBE
59.33
46%
-29
- C6 -
-
5EFH
7
?
D:
[10-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
--
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
-
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
-
S
K
H
-
I
S
I
I
K
S
S
----
E
H
M
K
P
R
D
L
NR
L
G
D
E
Y
N
S
I
F
I
S
--------------
N
E
--
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
--
N
S
-
E
--
D
--
A
N
YD
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
----
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
--
D
P
L
G
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
----
A
A
----
G
R
-
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
-------------------------------------
79
PsiBlast_CBE
51.53
32%
-36
- C6 -
-
5JI5
6
?
A:
[28-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
L
A
D
E
A
A
L
L
R
V
H
T
-
K
A
H
V
D
Y
L
R
A
R
S
P
Q
S
G
Y
A
-------------------------
E
I
D
P
D
T
S
M
N
P
-
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
V
-
H
K
L
E
-
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
P
---
F
Y
P
--
F
T
-
G
--
A
--
D
N
--
Q
A
P
N
M
C
----
N
V
P
I
A
A
R
S
------
K
G
M
V
----
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
--
H
R
E
D
D
L
G
N
M
A
L
V
E
D
D
Y
A
W
I
T
Q
Q
I
R
L
V
----
A
D
K
YAK
G
R
-
I
V
S
C
L
E
G
G
Y
N
L
S
A
L
G
R
S
V
V
A
H
V
R
A
L
----------------------------------------
91
PsiBlast_CBE
42.97
33%
-52
- C6 -
-
4ZUO
5
APHA_MYCRA
A:
[127-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L
G
--
Y
--
A
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
--------
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
--
Q
D
P
I
S
F
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
A
----
A
S
----
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
---------------------------------------------------
86
PsiBlast_CBE
42.95
33%
-52
- C6 -
-
4ZUQ
6
APHA_MYCRA
B:
[127-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L
G
--
Y
--
A
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
--------
P
M
G
R
G
T
PYSV
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
--
Q
D
P
I
S
F
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
A
----
A
S
----
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
---------------------------------------------------
90
PsiBlast_CBE
42.71
33%
-52
- C6 -
-
4ZUO
6
APHA_MYCRA
B:
[127-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L
G
--
Y
--
A
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
--------
P
M
G
R
G
T
PYSV
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
--
Q
D
P
I
S
F
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
A
----
A
S
----
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
---------------------------------------------------
87
PsiBlast_CBE
42.71
33%
-53
- C6 -
-
4ZUQ
6
APHA_MYCRA
A:
[127-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L
G
--
Y
--
A
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
--------
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
--
Q
D
P
I
S
F
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
A
----
A
S
----
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
---------------------------------------------------
92
PsiBlast_CBE
42.67
33%
-52
- C6 -
-
4ZUN
4
APHA_MYCRA
B:
[127-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L
G
--
Y
--
A
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
--------
P
M
G
R
G
T
PYSV
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
--
Q
D
P
I
S
F
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
A
----
A
S
----
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
---------------------------------------------------
88
PsiBlast_CBE
42.58
33%
-52
- C6 -
-
4ZUP
6
APHA_MYCRA
B:
[127-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L
G
--
Y
--
A
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
--------
P
M
G
R
G
T
PYSV
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
--
Q
D
P
I
S
F
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
A
----
A
S
----
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
---------------------------------------------------
93
PsiBlast_CBE
42.56
33%
-51
- C6 -
-
4ZUN
5
APHA_MYCRA
A:
[127-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L
G
--
Y
--
A
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
--------
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
--
Q
D
P
I
S
F
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
A
----
A
S
----
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
---------------------------------------------------
94
PsiBlast_CBE
42.55
33%
-52
- C6 -
-
4ZUM
5
APHA_MYCRA
B:
[127-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L
G
--
Y
--
A
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
--------
P
M
G
R
G
T
PYSV
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
--
Q
D
P
I
S
F
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
A
----
A
S
----
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
---------------------------------------------------
95
PsiBlast_CBE
42.31
33%
-53
- C6 -
-
4ZUM
6
APHA_MYCRA
A:
[127-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L
G
--
Y
--
A
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
--------
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
--
Q
D
P
I
S
F
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
A
----
A
S
----
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
---------------------------------------------------
89
PsiBlast_CBE
42.30
33%
-52
- C6 -
-
4ZUP
8
APHA_MYCRA
A:
[127-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
--
G
A
K
-
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
-
D
P
A
E
A
F
P
--
H
F
L
G
--
Y
--
A
E
--
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
--------
P
M
G
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
S
L
K
R
I
A
A
-
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
--
Q
D
P
I
S
F
F
K
L
T
S
P
--
D
Y
I
T
M
G
R
T
I
A
----
A
S
----
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
I
---------------------------------------------------