@TOME V2.3
(Mar 2018)

Ref. - - Doc.
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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : S7UUG9_TOXGG: (2017-06-15 )
MVDASEGSSKEEEAGHVPHVEVESGRNCGEAWTKTRSSPFTSVWHISGETGAAAGHCREGSLHKLIATNNISGVRLWLSNPFCRGMINDLNHAGETPLHVAVQCCSPRILSLLLDPPPLQISPSLLASCSLRLPRPLAGTAEPPSGAPASSNEGAPLGGSAEEVADAGVASLKTQQPFSAETAISSVVATDAAAACDQLAMAAAARVDFSLSVDGIPTLHLLIGRTAFGGARGEDAMECLKRILLHIGRFQPGAADRCPRCSPGKTKPTACGRERSGVKAESVAFECGDHVSDPQAGGLRESQISHPGLGGQQEYGCQCCGGTLGSLDSRRKKEMREARDRVCCPEVFTVERQTSAADSVMLDLEEMDLQGRTALHLACSFGVSPVAELLLHAGASPWARRLGLGQLPIHSAIDADDPACCLLLLRHTLPCRFFVNFSCICGRRCDSGATGGRQAPVNTLALKRSPAATKFVFQLVRRCVRRGAWRCFRALLLYPTESSACFSGSVEGGDKAEGLQPGGSNSAASRRCEVENLGRKEDACERQGGRVRCVTKDVAASWCSGLHGLLDGEVRAWLYLREEARRAGALLDLKEQLQRVVTTSPACCQAAAASWTAVPASPCDGHKFGVKSESETGLLLSLFGTRGDAEGKTAKRGEGRTMVVTHALCLEHLPLPEPADMPLKRHKLMQRFPENPSRLEVVTSDRCGILRTREFSPLLWMDDPMPASLSDILRVHSMSYIARLKLRVEDAFGISTRLPSLSPPLSYAPGQTAAAATATGAEALAAAAAALDSKLQKEQYEKQKRQQIENVGSAGRYSFVFADGDTPVTCFSWAAAVHAAGAVIAAVDAVCERKCRNAFCAVRPPGHHLGNWGAAQTASNQLTDEDIAAGSQGFCLLNNVAIGAAYAKYNYARKGIRRIAIVDFDVHHGNGTEQIIRNVGMKIRKVKQPQGAALRLYRRAADELRGTSTLVSSNLSRDAPAAGDNSAHCGPDPCEVDATGSEKTPSQGYHVGDGGKVSAALPPQLAGPVDVPQWMGWRDERDAEELFFASIHAFDGTFYPGTGADCEDFSGPVVINVNILPHPTGPSLHKCCRCQKCSGRPCAGGAHRRCPRGRDAGVSYANASPMEVEMAARTPDVPVQVSWSCHFCRHPTLAPSSVAARRLFLKRIIRPLLRFGPDLLFISAGFDGHAQDQIGGAFGGFAEEDFRFFTHALVRCAERTCEGRVVSVLEGGYSVSGGVSSTLAASVKEHLRGLMRTPAGGSCFAGALGSEEPSNEAHEVAPRESSLSFPGKNGWEEDIEVGDAATSDVTASDVEESWQLIEGENTGMDGADSSDALLDEGSRRNGSDDGPSADALSHRRPREAKTLDGCASPGPHASTETASEASGHCEREHSADFPPGADACRSRGTEHRSPTNAFASSASAPSAQRYGDSATVNNNDLLTLRALCRGTDGCLR

Atome Classification :

(12 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680--.......690.......700-........710.......720---.........730.......740.......750--........760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860--.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050.....--..1060--..---..---....1070......1080......1090......1100......1110-......1120......1130......1140......1150......1160......1170......1180......1190.....-----.1200......1210......1220......1230......1240......1250.....-.1260-----------..------------.....1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450
(Atome) (Ident) (Tito) (Num) (QMean) (Ligand) (Uniprot) MVDASEGSSKEEEAGHVPHVEVESGRNCGEAWTKTRSSPFTSVWHISGETGAAAGHCREGSLHKLIATNNISGVRLWLSNPFCRGMINDLNHAGETPLHVAVQCCSPRILSLLLDPPPLQISPSLLASCSLRLPRPLAGTAEPPSGAPASSNEGAPLGGSAEEVADAGVASLKTQQPFSAETAISSVVATDAAAACDQLAMAAAARVDFSLSVDGIPTLHLLIGRTAFGGARGEDAMECLKRILLHIGRFQPGAADRCPRCSPGKTKPTACGRERSGVKAESVAFECGDHVSDPQAGGLRESQISHPGLGGQQEYGCQCCGGTLGSLDSRRKKEMREARDRVCCPEVFTVERQTSAADSVMLDLEEMDLQGRTALHLACSFGVSPVAELLLHAGASPWARRLGLGQLPIHSAIDADDPACCLLLLRHTLPCRFFVNFSCICGRRCDSGATGGRQAPVNTLALKRSPAATKFVFQLVRRCVRRGAWRCFRALLLYPTESSACFSGSVEGGDKAEGLQPGGSNSAASRRCEVENLGRKEDACERQGGRVRCVTKDVAASWCSGLHGLLDGEVRAWLYLREEARRAGALLDLKEQLQRVVTTSPACCQAAAASWTAVPASPCDGHKFGVKSESETGLLLSLFGTRGDAEGKTAKRGEGRTMVVTHALCLEHLPLPEPADMPLKRH--KLMQRFPENPSRLEVVTSD--RCGILRTREFSPLLWMDDP-----MPASLSDILRVHSMSYIARLKLRVEDAFGIS---TRLPSLSPPLSYAPGQTAAAATATGAEALAAAAAALDSKLQKEQYEKQKRQQIENVGSAGRYSFVFADGDTPVTCFSWAAAVHAAGAVIAAVDAVCERKCRNAFCAVRPPG--HHLGNWGAAQTASNQLTDEDIAAGSQGFCLLNNVAIGAAYAKYNYARKGIRRIAIVDFDVHHGNGTEQIIRNVGMKIRKVKQPQGAALRLYRRAADELRGTSTLVSSNLSRDAPAAGDNSAHCGPDPCEVDATGSEKTPSQGYHVGDGGKVSAALPPQLAGPVDVPQWMGWRDERDAEELFFASIHAFD-GTFYPG--TGA--D--CE---DF---SGPVVINVNILPHPTGPSLHKCCRCQKCSGRPCAGGAHRRCPRGRDAG-VSYANASPMEVEMAARTPDVPVQVSWSCHFCRHPTLAPSSVAARRLFLKRIIRPLLRFGPDLLFISAGFDGHAQDQIGGAFGGFA-----EEDFRFFTHALVRCAERTCEGRVVSVLEGGYSVSGGVSSTLAASVKEHLRGLMRTPAGGS-CFAG------------AL------------GSEEPSNEAHEVAPRESSLSFPGKNGWEEDIEVGDAATSDVTASDVEESWQLIEGENTGMDGADSSDALLDEGSRRNGSDDGPSADALSHRRPREAKTLDGCASPGPHASTETASEASGHCEREHSADFPPGADACRSRGTEHRSPTNAFASSASAPSAQRYGDSATVNNNDLLTLRALCRGTDGCLR
148 HHSearch 72.4940% -24 - C3 - - 5JI5 ? A:[10-314] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATGFYSHADCLQHEM----------------GQWHPECPARLQAIEDQLIASRIGE-----LI-ERESA-----PLADEAALLRVHTKAHVDYLRARSPQS--------------------------------------------------GY------------------A-EIDPDTSMNPHTWTAALRAAGAAVAATDAVIEGRYDNAFCSVRPPG--HHAEP-----------------ARAMGFCFFNNVAIAARHALEVH---KLERVAIIDFDVHHGNGTEAAFSND--------------------------------------------------------------------------------------------------------ARVLMCSIFQH---PFYPF--TGA--D--NQ---------APNMCNVPIAA-----------------------------------R-SK-------------------------------------GMVVREAIDMIWLPRLDAFKPQMLFVSAGFDAHREDDLGN--MALV-----EDDYAWITQQIRLVADKYAKGRIVSCLEGGYNLSA-----LGRSVVAHVRALAD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145 HHSearch 71.5227% -33 * C3 * - 5G0G ? A:[21-378] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KATGTGLVYVDAFTRFHCLWD--------------ASHPECPARVSTVMEMLETEGLLGRC------VQVEA-----RAVTEDELLLVHTKEYVELMKSTQNMTE------------------------------------------------EEL--------------KTL--AEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPG--HHAQA-----------------DKMNGFCMFNNLAIAARYAQKRH---RVQRVLIVDWDVHHGQGIQYIFEED--------------------------------------------------------------------------------------------------------PSVLYFSVHRYEDGSFWPH--LKESDS--SS---VGSGAGQGYNINLPWNKV----------------------------------G-ME-------------------------------------SGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGG--MQVS-----PECFSILTHMLKGVA----QGRLVLALEGGYNLQS-----TAEGVCASMRSLLGDPCPHL-PSS-----------------------------GAPCESALKSISK---TISDLYPFWKSLQ-------------------------------------------------------------------------------------------------------------------------------------------------------------
152 HHSearch 70.6728% -39 - C3 - - 5EDU HDAC6_HUMAN (first) B:[386-744] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAASRTGLVYDQNMMNHCNLW--------------DSHHPEVPQRILRIMCRLEELGLAGR-----C-LTLTP-----RPATEAELLTCHSAEYVGHLRATEKMK-----------------------TR-------------------------E---LHR--------ES-----SNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPG--HHAEQ-----------------DAACGFCFFNSVAVAARHAQTIS--GHALRILIVDWDVHHGNGTQHMFEDD--------------------------------------------------------------------------------------------------------PSVLYVSLHRYDHGTFFPMGDEGA--S--SQ---IGRAAGTGFTVNVAWNGP----------------------------------R-MG-------------------------------------DADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGG--CQVS-----PEGYAHLTHLLMGLA----SGRIILILEGGYNLTS-----ISESMAACTRSLLGDPPPLL-T-------------------------------RPPLSGALASITE---TIQVHRRYWRSL--------------------------------------------------------------------------------------------------------------------------------------------------------------
156 HHSearch 68.1824% -42 - C3 - - 4ZUR APHA_MYCRA A:[1-341] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRVIFSEDHKLRNAKTE-----LYGG--E-LVPPFEAPFRAEWILAA------VKEAGFD---DVVAP-----ARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRT-------------------------SPRIPTDI----E---------GQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGH-KAAFSLCRPPG--HHAGI-----------------DMFGGYCFINNAAVAAQRLLD----KGAKKIAILDVDFHHGNGTQDIFYER--------------------------------------------------------------------------------------------------------GDVFFASLHGDP-AEAFPHF-LGY--A--EE---TGKGAGAGTTANYPMGR-----------------------------------G-TP-------------------------------------YSVWGEALTD-SLKRIAAFGAEAIVVSLGVDTFEQDPISF--FKLT-----SPDYITMGRTIAA-----SGVPLLVVMEGGYGVPE-----IGLNVANVLKGVAG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147 HHSearch 67.9826% -38 - C3 - - 1ZZ1 HDAH_ALCSD A:[2-333] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIGYVWNTLYGWVDTGTGSLAAANLTARMQPISHHLAHPDTKRRFHELVCASGQIEH-----L-TPIAA-----VAATDADILRAHSAAHLENMKRVSNLP-----------------------T-------------------------------------G---G-----DTGDGITMMGNGGLEIARLSAGGAVELTRRVATGELSAGYALVNPPG--HHAPH-----------------NAAMGFCIFNNTSVAAGYARAVL---GMERVAILDWDVHHGNGTQDIWWND--------------------------------------------------------------------------------------------------------PSVLTISLHQHL--CFPPD--SGY--S--TE---RGAGNGHGYNINVPLPP-----------------------------------G-SG-------------------------------------NAAYLHAMDQVVLPALRAYRPQLIIVGSGFDASMLDPLAR--MMVT-----ADGFRQMARRTIDCAADICDGRIVFVQEGGYSPHY-----LPFCGLAVIEELTGVRS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149 HHSearch 67.8525% -26 - C3 - - 5G0H ? A:[404-763] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPITGLVYDQRMMLHHNMW--------------DSHHPELPQRISRIFSRHEELRLLSRC------HRIPA-----RLATEEELALCHSSKHISIIKSSEHMKP------R------------------------------------------DL----N----------R--LGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPG--HHAEK-----------------DTACGFCFFNTAALTARYAQSIT--RESLRVLIVDWDVHHGNGTQHIFEED--------------------------------------------------------------------------------------------------------DSVLYISLHRYEDGAFFPN--SED--ANYDK---VGLGKGRGYNVNIPWNG-----------------------------------GKMG-------------------------------------DPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGG--FQVT-----PEGYAHLTHQLMSLA----AGRVLIILEGGYNLTS-----ISESMSMCTSMLLGDSPPSL-DH-----------------------------LTPLKTSATVSINN---VLRAHAPFWSSLRVN-----------------------------------------------------------------------------------------------------------------------------------------------------------
143 HHSearch 65.9925% -24 - C3 - - 5EEI ? A:[8-364] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PITGLVYDQRMMLHHNMW--------------DSHHPELPQRISRIFSRHEELRLLSR-----C-HRIPA-----RLATEEELALCHSSKHISIIKSSEHMKP------------------------------------------------RD---L-----------NR--LGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPG--HHAEK-----------------DTACGFCFFNTAALTARYAQSIT--RESLRVLIVDWDVHHGNGTQHIFEED--------------------------------------------------------------------------------------------------------DSVLYISLHRYEDGAFFPN--SEDANY--DK---VGLGKGRGYNVNIPWNG-----------------------------------GKMG-------------------------------------DPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGG--FQVT-----PEGYAHLTHQLMSLA----AGRVLIILEGGYNLTS-----ISESMSMCTSMLLGDSPPSL-DH-----------------------------LTPLKTSATVSINN---VLRAHAPFWSSLR-------------------------------------------------------------------------------------------------------------------------------------------------------------
154 HHSearch 56.0117% -3 - C3 - - 4LY1 HDAC2_HUMAN A:[2-367] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKKVCYYYDGDIGNYYY----------------GQGHPMKPHRIRMTHNLLLNYGLYRKM------EIYRP-----HKATAEEMTKYHSDEYIKFLRSIRPDNMS------------------------------------------------EYSKQ----------MQR--FNV-GEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNW-AGGL--HHAKK-----------------SEASGFCYVNDIVLAILELLKY-----HQRVLYIDIDIHHGDGVEEAFYTT--------------------------------------------------------------------------------------------------------DRVMTVSFHKYG--EYFPG--TGD--L--RD---IGAGKGKYYAVNFPMRD-----------------------------------G-ID-------------------------------------DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGC--FNLT-----VKGHAKCVEVVKTF-----NLPLLMLGGGGYTIRN-----VARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHIS------------PSNMTNQNTPEYMEK---IKQRLFENLRML--------------------------------------------------------------------------------------------------------------------------------------------------------------
153 HHSearch 55.7921% -25 - C3 - - 4A69 HDAC3_HUMAN A:[2-319] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKTVAYFYDPDVGNFHY----------------GAGHPMKPHRLALTHSLVLHYGLYKKM------IVFKP-----YQASQHDMCRFHSEDYIDFLQRVSPTNMQ------------------------------------------------GFTKS----------LNA--FNV-GDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWA-GGL--HHAKK-----------------FEASGFCYVNDIVIGILELLK-----YHPRVLYIDIDIHHGDGVQEAFYLT--------------------------------------------------------------------------------------------------------DRVMTVSFHKYG-NYFFPG--TGD--M--YE---VGAESGRYYCLNVPLRD-----------------------------------G-ID-------------------------------------DQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGC--FNLS-----IRGHGECVEYVKSF-----NIPLLVLGGGGYTVRN-----VARCWTYETSLLVEEAI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158 HHSearch 55.4217% 3 - C3 - - 4BKX HDAC1_HUMAN B:[8-374] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRKVCYYYDGDVGNYYY----------------GQGHPMKPHRIRMTHNLLLNYGLYRKM------EIYRP-----HKANAEEMTKYHSDDYIKFLRSIRPDNMS------------------------------------------------EYSKQ----------MQR--FNV-GEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNW-AGGL--HHAKK-----------------SEASGFCYVNDIVLAILELLKY-----HQRVLYIDIDIHHGDGVEEAFYTT--------------------------------------------------------------------------------------------------------DRVMTVSFHKYG--EYFPG--TGD--L--RD---IGAGKGKYYAVNYPLRD-----------------------------------G-ID-------------------------------------DESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGC--FNLT-----IKGHAKCVEFVKSF-----NLPMLMLGGGGYTIRN-----VARCWTYETAVALDTEIPNELPYND------------YFEYFGPDFKLHISPSNMTNQNTNEYLEK---IKQRLFENLRMLP-------------------------------------------------------------------------------------------------------------------------------------------------------------
155 HHSearch 55.0219% -23 - C3 - - 5DC8 HDAC8_HUMAN A:[14-326] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVPVYIYSPEYVSMC------------------DSLAKIPKRASMVHSLIEAYALHKQM------RIVKP-----KVASMEEMATFHTDAYLQHLQKVSQEGD------D-----------------------------------------D----HPD--------SIE--YGL-GYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW--AHAKK-----------------DEASGFCYLNDAVLGILRLRR-----KFERILYVDLDLHHGDGVEDAFSFT--------------------------------------------------------------------------------------------------------SKVMTVSLHKFS-PGFFPG--TGD--V--SD---VGLGKGRYYSVNVPIQD-----------------------------------G-IQ-------------------------------------DEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCS--FNMT-----PVGIGKCLKYILQW-----QLATLILGGGGFNLAN-----TARCWTYLTGVILGKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------