@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S8GEI3_TOXGM: (2017-06-15 )
MVDASEGSSKEEEAGHVPHVEVESARNCGEAWTKTRSSPFTSVWHISGETGAAAGHCREGSLHKLIATNNISGVRLWLSNPFCRSMINDLNHAGETPLHVAVQCCSPRILSLLLDPPPLQISPSLLASCSLRLPRPLAGTAEPPSGAPASSNEGAPLGGSAEEVADAGVASLKTQQPFSAETAISSVVATDAAAACDQLAMAAAARVDFSLSVDGIPTLHLLIGRTAFGGARGEDAMECLKRILLHIGRFQPGAADRCPRCSPGKTKPTACGRERSGVKAESVAFECGDHVSDPQAGGLRESQISHPGLGGQQEYGCQCCGGTLGSLDSRRKKEMREARDRVCCPEVFTVERQTSAADSVMLDLEEMDLQGRTALHLACSFGVSPVAELLLHAGASPWARRLGLGQLPIHSAIDADDPACCLLLLRHTLPCRFFVNFSCICGRRCDSGATGGRQAPVNTLALKRSPAATKFVFQLVRRCVRRGAWRCFRALLLYPTESSACFSGSVEGGDKAEGLQPGGSNSAASRRCEVENLGRKEDACERQGGRVRCVTKDVAASWCSGLHGLLDGEVRAWLYLREEARRAGALLDLKEQLQRVVTTSPACCQAAAASWTAVPASPCDGHKFGVKSESETGLLLSLFGTHGDAEGKTAKRGEGRTMVVTHALCLEHLPLPEPADMPLKRHKLMQRFPENPSRLEVVTSDRCGILRTREFSPLLWMDDPMPASLSDILRVHSMSYIARLKLRVEDAFGISTRLPSLSPPLSYAPGQTAAAATATGAEALAAAAAALDSKLQKEQYEKQKRQQIENVGSAGRYSFVFADGDTPVTCFSWAAAVHAAGAVIAAVDAVCERKCRNAFCAVRPPGHHLGNWGAAQTASNQLTDEDIAAGSQGFCLLNNVAIGAAYAKYNYARKGIRRIAIVDFDVHHGNGTEQIIRNVGMKIRKVKQPQGAALRLYRRAADELRGTSTLVSSNLSRDAPAAGDNSAHCGPDPCEVDATGSEKTPSQGYHVGDGGKVSAALPPQLAGPVDVPQWMGWRDERDAEELFFASIHAFDGTFYPGTGADCEDFSGPVVINVNILPHPTGPSLHKCCRCQKCSGRPCAGGAHRRCPRGRDAGVSYANASPMEVEMAARTPDVPVQVSWSCHFCRHPTLAPSSVAARRLFLKRIIRPLLRFGPDLLFISAGFDGHAQDQIGGAFGGFAEEDFRFFTHALVRCAERTCEGRVVSVLEGGYSVSGGVSSTLAASVKEHLRGLMRTPAGGSCFAGALGSEQPGNEAHEAAPRESSLSFPGKNGWEEDIEVGDAATSDVTASDVEESWQLIEGENTGMDGADSSDALLDEGSRRNGSDDGPSADALSHRRPREAKTLDGCASPGPHSSTETASEASGHCEREHSADFPPGADACRSRGTEHRSPTNAFASSASAPSAQRYGDSATVNNNDLLTLRALCRGTDGCLR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.....-------..410.......420.......430.......--440.......450.......460.......470..---.....480.......490.......500....---...510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620....------...630.......640.......650..-.....660.......--670.......680.--......690.......700-........710.......720---.........730.......740..------.....750---.........760.......770.......780.......790......--------.800.......810......-----------.820.......830.......840.......850.......860--.......870.......880.......890.......900.......910.......920.......930.----------------------------------.------.....940--...----.....950.......960......-------.970--........980-----........990----...--....1000--------......1010......1020..----......1030......1040......1050....-----.--.-.1060--.--.---..---....1070.....-----------.1080......1090.....-----.1100.....--.1110-......1120......1130......1140......1150.......1160......1170......1180......1190.....-----.1200......1210......1220......1230......1240......1250......1260......1270-.....-..1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVDASEGSSKEEEAGHVP
H
V
E
V
E
S
A
RN
C
G
E
A
W
TKTRSSPF
T
S
V
W
H
ISGETGAAAGHCREGS
L
H
K
L
I
ATNNI
S
G
V
R
L
W
LSN
P
F
C
R
S
M
I
N
D
L
N
HAGET
P
L
H
V
A
V
Q
CC
S
P
R
I
L
S
L
LLDPPPLQI
S
P
S
L
L
A
S
C
SLRLPRPLAGTAEPPSGAPASSNEGAPLGG
S
A
E
E
V
A
D
AG
V
A
SLKTQQPFS
A
E
T
A
I
S
S
V
V
A
T
D
A
A
A
A
C
D
Q
L
A
M
A
A
A
A
R
V
D
F
S
L
SVDGI
P
T
L
H
L
L
IGRTAFGGAR
G
E
D
A
M
E
C
L
K
R
I
L
L
HIGRFQPGAADRCPRCSPGKTKPTACGRERSGVKAE
S
V
A
F
ECGDHVSDPQAGGLRESQISHPGLGGQQEYG
C
Q
CCGGTLG
S
L
D
S
R
R
K
K
E
M
R
E
A
RDRVCCPE
V
F
T
V
ERQTSAAD
S
V
M
L
D
L
E
EMDLQG
R
T
A
L
H
L
A
CSF
G
V
S
P
V
A
E
L
L
L
HAGA
S
P
W
A
R
RLGLGQL-------PIHSAIDAD
D
P
A
C
C
L
L
L
L
R
HTLP
C
R
F
F
V
N
F
S
C
--
I
CGRRCDSGATGGRQAPV
N
T
L
A
LKRSP
A
A
T
K
F
V
F
Q
---
L
V
R
R
C
V
R
R
G
A
W
R
C
F
R
A
L
LLYPTESSACFSGSV---EGGDKAEGLQPGGSNSAASRRC
E
V
E
NLGRK
E
D
A
C
E
RQG
G
R
V
R
C
V
T
K
D
V
A
A
S
W
C
S
G
L
H
G
LLDG
E
V
R
A
W
L
Y
L
R
E
E
A
R
RAG
A
L
L
D
L
K
E
Q
L
Q
R
V
VTTS
P
A
C
C
Q
A
AAASWTAVPASPCDGHKFGV------KSESET
G
L
L
L
S
L
FGTHGDAEGKTAKRGE-G
R
T
M
V
V
T
H
A
L
C
L
E
HL--PLPEPADM
P
L
K
R
H
K
--
L
M
Q
RFPENPS
R
L
E
V
V
TSD--RC
G
I
L
RTREFS
P
L
L
W
MDDP-----MP
A
S
L
S
D
I
L
R
V
H
S
M
S
Y
I
A
R
L
K
L
R
V
------
E
DAFGI-----STRLPSLSPPLSYAPGQTAAAATAT
G
A
E
A
L
A
A
A
A
A
A
L
D
S
K
L
Q
K
E
Q
Y
E
K
--------
Q
K
R
Q
Q
I
E
NVGSAG
R
Y
S
F
V
F
A-----------DGDT
P
V
T
C
F
S
W
A
A
A
V
H
AA
G
A
V
I
A
A
V
D
A
V
C
E
R
K
C
RN
A
F
C
AVRPPG--HHLGNWGAAQTASNQLT
D
E
D
IAAGSQ
G
F
C
L
L
NNVAIG
A
A
Y
A
K
Y
N
Y
A
R
KG
I
R
R
I
A
I
V
D
F
D
VHHGN
G
T
E
Q
I
I
R
----------------------------------
N
------V
G
M
K
I
R
K---VKQ----PQ
G
A
A
L
R
L
Y
R
R
A
A
D
E
LRG
T
S
T
L
V
S-------SNL---SRDAPAAGDN------SAHCGPDPCEV----DAT--GSEKTPSQ--------GYHVGDGG
K
V
SAALPPQL--AG----PVD
V
P
Q
WMGWRDER
D
A
E
E
L
F
F
A
S
I
H
AFD-GTFYP-----G--T-GA--D--C--E---DF---SG
P
V
V
I
N
V
N
I
LPH-----------PTGP
S
L
H
K
C
C
R
CQKCSGRPC-----AGGAHRRCPR--GRDAG-VSYANAS
P
M
E
V
E
M
AARTPDV
P
V
Q
V
S
W
S
C
HFCRHPTLA
P
-
S
S
V
A
A
R
R
L
F
L
K
R
I
I
R
P
L
L
R
FGP
D
L
L
F
I
SAGFDGHA
Q
D
QIGGAFGGF
A
-----
E
E
D
F
R
F
F
T
H
A
L
V
R
C
A
E
RTCEG
R
V
V
S
V
LEGGYSVSGG
V
S
S
T
L
A
A
S
V
K
E
H
L
R
G
L
MRTPAGGS
C
F
AGALGSEQPGNE--AHEAA-PRESSLSFPGKNGW
E
E
DIEVGDAATSDV
T
A
S
D
V
E
E
S
W
Q
LIEGENTGMDGADSS
D
A
L
L
DEGSRRNGSDDGPSA
D
A
LSHRRPREAKTLDGCASPGPHSSTETASEASGHCEREHSADFPP
G
A
D
A
C
R
SRGTEHRSP
T
N
A
FASSASAP
S
A
Q
RYGD
S
A
TVNNN
D
L
L
T
L
R
A
L
CRGTDGCLR
157
HHSearch
72.93
29%
-40
- C3 -
-
5EDU
4
HDAC6_HUMAN (first)
B:
[387-745]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
-
S
R
T
G
L
V
Y
D
Q
N
M
M
N
H
C
--
N
L
W
--------------
D
S
H
H
P
E
V
P
Q
R
I
L
R
I
M
C
R
L
E
E
L
G
L
A
G
R
-----
C
-
L
T
L
T
P
-----
R
P
A
T
E
A
E
L
L
T
C
H
S
A
E
Y
V
G
H
L
R
A
T
E
------
K
M
K
-------------------------
T
R
------------------------
E
------------
L
H
-----------
R
E
S
--
S
N
-----------
F
D
S
I
Y
I
C
P
S
T
F
A
C
A
Q
L
A
T
G
A
A
C
R
L
V
E
A
V
L
S
G
E
V
L
N
G
A
A
V
V
R
P
P
G
--
H
H
A
E
Q
-----------------
D
A
A
C
G
F
C
F
F
N
S
V
A
V
A
A
R
H
A
Q
T
I
S
--
G
H
A
L
R
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
M
F
E
----------------------------------
D
------
D
---------------------------------------------------------------------------------------------------------------------------------------------------
P
S
V
L
Y
V
S
L
H
R
Y
D
H
G
T
F
F
P
-----
M
GD
E
-
G
A
--
S
--
S
--
Q
---
I
G
RAA
G
T
G
F
T
V
N
V
A
W
N
G
P
----------------------------------------------------
R
-
M
G
--------------------------------------
D
A
D
Y
L
A
A
W
H
R
L
V
L
P
I
A
Y
E
F
N
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
G
G
--
C
Q
V
S
-----
P
E
G
Y
A
H
L
T
H
L
L
M
G
L
A
----
S
G
R
I
I
L
I
L
E
G
G
Y
N
L
T
S
-----
I
S
E
S
M
A
A
C
T
R
S
L
L
G
D
P
P
P
L
L
T
-------
R
P
P
L
S
G
--
A
L
A
S
I
-
T
E
---
T
I
Q
V
H
R
R
Y
W
R
S
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
150
HHSearch
72.50
40%
-24
- C3 -
-
5JI5
6
?
A:
[10-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
G
F
Y
S
H
A
D
C
L
Q
H
E
--
M
----------------
G
Q
W
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
-----
L
I
-
E
R
E
S
A
-----
P
L
A
D
E
A
A
L
L
R
V
H
T
K
A
H
V
D
Y
L
R
A
R
S
------
P
Q
S
----------------------------------------------------
G
-------------------------
Y
-
A
-
E
I
-----------
D
P
D
T
S
M
N
P
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
G
--
H
H
A
E
P
-----------------
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
V
H
---
K
L
E
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
----------------------------------
N
------
D
---------------------------------------------------------------------------------------------------------------------------------------------------
A
R
V
L
M
C
S
I
F
Q
H
---
P
F
Y
P
-----
F
--
T
-
G
A
--
D
--
N
--
Q
---------
A
P
N
M
C
N
V
P
I
A
A
-----------------------------------------------------
R
-
S
K
--------------------------------------
G
M
V
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
E
D
D
L
G
N
--
M
A
L
V
-----
E
D
D
Y
A
W
I
T
Q
Q
I
R
L
V
A
D
K
Y
A
K
G
R
I
V
S
C
L
E
G
G
Y
N
L
S
A
-----
L
G
R
S
V
V
A
H
V
R
A
L
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
HHSearch
69.51
27%
-32
- C3 -
-
5G0G
9
?
A:
[21-378]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
-
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
--
C
L
W
--------------
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
-----
C
-
V
Q
V
E
A
-----
R
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
------
N
M
T
-------------------------
E
-------------------------
E
E
L
----------------------
K
T
L
--
A
E
K
-----------
Y
D
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
G
--
H
H
A
Q
A
-----------------
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
---
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
----------------------------------
E
------
D
---------------------------------------------------------------------------------------------------------------------------------------------------
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
-----
H
--
L
-
K
E
SD
S
--
S
--
S
---
V
G
SGA
G
Q
G
Y
N
I
N
L
P
W
N
K
V
----------------------------------------------------
G
-
M
E
--------------------------------------
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
G
G
--
M
Q
V
S
-----
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
----
Q
G
R
L
V
L
A
L
E
G
G
Y
N
L
Q
S
-----
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
P
C
P
H
L
P
S
S
-----
G
A
P
C
E
S
--
A
L
K
S
I
-
S
K
---
T
I
S
D
L
Y
P
F
W
K
S
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------
149
HHSearch
68.57
26%
-39
- C3 -
-
1ZZ1
4
HDAH_ALCSD
A:
[2-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
G
Y
V
W
N
T
L
Y
G
W
V
D
--
T
G
T
G
S
L
A
A
A
N
L
T
A
R
MQ
P
I
S
H
H
L
A
H
P
D
T
K
R
R
F
H
E
L
V
C
A
S
G
Q
I
E
H
-----
L
-
T
P
I
A
A
-----
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
L
E
N
M
K
R
V
S
------
N
L
P
-------------------------
T
---------------------------------------------
G
---
G
-----
D
T
G
-----------
D
G
I
T
M
M
G
N
G
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
--
H
H
A
P
H
-----------------
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
---
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
----------------------------------
N
------
D
---------------------------------------------------------------------------------------------------------------------------------------------------
P
S
V
L
T
I
S
L
H
Q
H
L
--
C
F
P
P
-----
D
--
S
-
G
Y
--
S
--
T
--
E
---
R
G
AGN
G
H
G
Y
N
I
N
V
P
L
P
P
-----------------------------------------------------
G
-
S
G
--------------------------------------
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
S
M
L
D
P
L
A
R
--
M
M
V
T
-----
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
-----
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
HHSearch
65.40
25%
-24
- C3 -
-
5G0H
14
?
A:
[404-763]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
--
N
M
W
--------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
------
H
R
I
P
A
-----
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
I
K
S
S
E
------
H
M
K
--------
P
------------------------------------------
R
D
-----------
L
-----------
N
R
--
L
G
D
E
-----------
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
-----------------
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
--
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
----------------------------------
E
------
D
---------------------------------------------------------------------------------------------------------------------------------------------------
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
-----
N
--
S
-
E
D
--
A
NY
D
--
K
---
V
G
LGK
G
R
G
Y
N
V
N
I
P
W
N
G
-----------------------------------------------------
G
K
M
G
--------------------------------------
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
G
G
--
F
Q
V
T
-----
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
-----
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
---
H
--
L
T
P
L
K
T
S
--
A
T
V
S
I
-
N
N
---
V
L
R
A
H
A
P
F
W
S
S
L
R
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------
152
HHSearch
63.94
27%
-32
- C3 -
-
3MEN
12
APHA_BURP1
A:
[21-359]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
L
T
Y
F
H
P
D
Q
S
L
H
H
--
P
R
T
Y
F
S
-----
R
G
R
---
M
R
M
P
Q
E
V
P
E
R
A
A
R
L
V
A
A
------
A
F
A
M
G
---
F
-
P
V
R
E
P
-----
D
D
F
G
I
A
P
I
A
A
V
H
D
T
H
Y
L
R
F
L
E
T
V
H
------
R
E
W
K
A
M
PEDWG
D
E
A
M
S
N
I
F
V
R
E
P
N
---------------------------
A
L
-----
R
--------
G
V
L
A
------
Q
A
A
R
---
H
L
A
-----------
D
G
S
C
P
V
G
E
H
T
W
R
A
A
Y
W
S
A
Q
S
A
L
A
A
A
A
A
V
R
D
G
A
-
P
A
A
Y
A
L
C
R
P
P
G
--
H
H
A
R
V
-----------------
D
A
A
G
G
F
C
Y
L
N
N
A
A
I
A
A
Q
A
L
R
A
-----
R
H
A
R
V
A
V
L
D
T
D
M
H
H
G
Q
G
I
Q
E
I
F
Y
----------------------------------
A
------
R
---------------------------------------------------------------------------------------------------------------------------------------------------
R
D
V
L
Y
V
S
I
H
G
D
P
-
T
N
F
Y
P
-----
A
--
V
A
G
F
--
D
--
D
--
E
---
R
G
AGE
G
L
G
Y
N
V
N
L
P
M
P
H
-----------------------------------------------------
G
-
S
S
--------------------------------------
E
A
A
F
F
E
R
V
D
D
-
A
L
R
E
L
R
R
F
A
P
D
A
L
V
L
S
L
G
F
D
V
Y
R
D
D
P
Q
S
Q
--
V
A
V
T
-----
T
D
G
F
G
R
L
G
H
L
I
G
A
L
-----
R
L
P
T
V
I
V
Q
E
G
G
Y
H
I
E
S
-----
L
E
A
N
A
R
S
F
F
G
G
F
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
HHSearch
63.68
25%
-23
- C3 -
-
5EEI
12
?
A:
[8-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
--
N
M
W
--------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
-----
C
-
H
R
I
P
A
-----
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
I
K
S
S
E
------
H
M
K
-------------------------
P
-------------------------
R
D
-----------
L
-----------
N
R
--
L
G
D
E
-----------
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
-----------------
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
--
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
----------------------------------
E
------
D
---------------------------------------------------------------------------------------------------------------------------------------------------
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
-----
N
--
S
-
E
D
AN
Y
--
D
--
K
---
V
G
LGK
G
R
G
Y
N
V
N
I
P
W
N
G
-----------------------------------------------------
G
K
M
G
--------------------------------------
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
P
L
G
G
--
F
Q
V
T
-----
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
G
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
-----
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
---
L
--
T
P
L
K
T
S
--
A
T
V
S
I
-
N
N
---
V
L
R
A
H
A
P
F
W
S
S
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
158
HHSearch
61.76
24%
-4
- C3 -
-
4ZUR
7
APHA_MYCRA
A:
[1-340]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
V
I
F
S
E
D
H
K
L
R
N
--
A
K
T
E
-----
L
Y
G
G
E
---
L
V
P
P
F
E
A
P
F
R
A
E
W
I
L
A
A
V
K
E
A
G
F
D
---------
D
V
V
A
P
-----
A
R
H
G
L
E
T
V
L
K
V
H
D
A
G
Y
L
N
F
L
E
T
A
W
------
D
R
W
K
A
A
GYK--
G
E
A
I
A
T
S
F
P
V
R
R
T
----------------------
S
P
R
---
I
P
T
D
I
------------
E
---------
G
Q
I
G
Y
Y
C
N
-----------
A
A
E
T
A
I
S
P
G
T
W
E
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
--
H
H
A
G
I
-----------------
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
----
K
G
A
K
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
----------------------------------
E
------
R
---------------------------------------------------------------------------------------------------------------------------------------------------
G
D
V
F
F
A
S
L
H
G
D
P
-
A
E
A
F
P
-----
H
F-
L
-
G
Y
--
A
--
E
--
E
---
T
G
KGA
G
A
G
T
T
A
N
Y
P
M
G
R
-----------------------------------------------------
G
-
T
P
--------------------------------------
Y
S
V
W
G
E
A
L
T
D
-
S
L
K
R
I
A
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
F
E
Q
D
P
I
S
F
--
F
K
L
T
-----
S
P
D
Y
I
T
M
G
R
T
I
A
A
-----
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
V
P
E
-----
I
G
L
N
V
A
N
V
L
K
G
V
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
HHSearch
59.28
19%
-14
- C3 -
-
4A69
8
HDAC3_HUMAN
A:
[2-370]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
T
V
A
Y
F
Y
D
P
D
V
G
N
F
H
--
Y
----------------
G
A
G
H
P
M
K
P
H
R
L
A
L
T
H
S
L
V
L
H
Y
G
L
Y
K
K
M
------
I
V
F
K
P
-----
Y
Q
A
S
Q
H
D
M
C
R
F
H
S
E
D
Y
I
D
F
L
Q
R
V
S
------
P
T
N
M
Q
--------------------------------------------------
G
F
T
K
--------
S
----------
L
N
A
F
--
N
V
------------
G
D
D
C
P
V
F
P
G
L
F
E
F
C
S
R
Y
T
G
A
S
L
Q
G
A
T
Q
L
N
N
K
I
C
D
I
A
I
N
W
A
-
G
G
L
--
H
H
A
K
K
-----------------
F
E
A
S
G
F
C
Y
V
N
D
I
V
I
G
I
L
E
L
L
K
-----
Y
H
P
R
V
L
Y
I
D
I
D
I
H
H
G
D
G
V
Q
E
A
F
Y
----------------------------------
L
------
T
---------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
M
T
V
S
F
H
K
Y
G
-
N
Y
F
F
P
-----
G
--
T
-
G
D
--
M
--
Y
--
E
---
V
G
AES
G
R
Y
Y
C
L
N
V
P
L
R
D
-----------------------------------------------------
G
-
I
D
--------------------------------------
D
Q
S
Y
K
H
L
F
Q
P
V
I
N
Q
V
V
D
F
Y
Q
P
T
C
I
V
L
Q
C
G
A
D
S
L
G
C
D
R
L
G
C
--
F
N
L
S
-----
I
R
G
H
G
E
C
V
E
Y
V
K
S
F
-----
N
I
P
L
L
V
L
G
G
G
G
Y
T
V
R
N
-----
V
A
R
C
W
T
Y
E
T
S
L
L
V
E
E
A
---------
I
S
E
E
L
P
Y
S
E
--
Y
F
E
Y
F
-
A
P
D
F
T
L
H
P
D
V
S
T
R
I
---
E
N
Q
N
S
R
Q
Y
L
D
Q
I
R
Q
T
I
F
E
N
L
K
M
L
N
--------------------------------------------------------------------------------------------------------------------------------------
151
HHSearch
57.60
17%
-5
- C3 -
-
4LY1
7
HDAC2_HUMAN
A:
[2-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
K
K
V
C
Y
Y
Y
D
G
D
I
G
N
Y
Y
--
Y
----------------
G
Q
G
H
P
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Y
G
L
Y
R
K
M
------
E
I
Y
R
P
-----
H
K
A
T
A
E
E
M
T
K
Y
H
S
D
E
Y
I
K
F
L
R
S
I
R
------
P
D
N
M
--------------------------------------------------
S
E
Y
S
K
--------
Q
----------
M
Q
R
F
--
N
V
------------
G
E
D
C
P
V
F
D
G
L
F
E
F
C
Q
L
S
T
G
G
S
V
A
G
A
V
K
L
N
R
Q
Q
T
D
M
A
V
N
W
-
A
G
G
L
--
H
H
A
K
K
-----------------
S
E
A
S
G
F
C
Y
V
N
D
I
V
L
A
I
L
E
L
L
K
Y
-----
H
Q
R
V
L
Y
I
D
I
D
I
H
H
G
D
G
V
E
E
A
F
Y
----------------------------------
T
------
T
---------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
M
T
V
S
F
H
K
Y
G
--
E
Y
F
P
-----
G
--
T
-
G
D
--
L
--
R
--
D
---
I
G
AGK
G
K
Y
Y
A
V
N
F
P
M
R
D
-----------------------------------------------------
G
-
I
D
--------------------------------------
D
E
S
Y
G
Q
I
F
K
P
I
I
S
K
V
M
E
M
Y
Q
P
S
A
V
V
L
Q
C
G
A
D
S
L
S
G
D
R
L
G
C
--
F
N
L
T
-----
V
K
G
H
A
K
C
V
E
V
V
K
T
F
-----
N
L
P
L
L
M
L
G
G
G
G
Y
T
I
R
N
-----
V
A
R
C
W
T
Y
E
T
A
V
A
L
D
C
E
---------
I
P
N
E
L
P
Y
N
D
--
Y
F
E
Y
F
-
G
P
D
F
K
L
H
I
S
P
S
-
N
M
---
T
N
Q
N
T
P
E
Y
M
E
K
I
K
Q
R
L
F
E
N
L
R
M
L
P
--------------------------------------------------------------------------------------------------------------------------------------
146
HHSearch
57.33
17%
-2
* C3 *
-
4BKX
8
HDAC1_HUMAN
B:
[8-376]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
R
K
V
C
Y
Y
Y
D
G
D
V
G
N
Y
Y
--
Y
----------------
G
Q
G
H
P
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Y
G
L
Y
R
K
M
------
E
I
Y
R
P
-----
H
K
A
N
A
E
E
M
T
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
R
------
P
D
N
-------------------------
M
-------------------------
S
E
Y
S
K
--------
Q
----------
M
Q
R
F
--
N
V
------------
G
E
D
C
P
V
F
D
G
L
F
E
F
C
Q
L
S
T
G
G
S
V
A
S
A
V
K
L
N
K
Q
Q
T
D
I
A
V
N
W
A
-
G
G
L
--
H
H
A
K
K
-----------------
S
E
A
S
G
F
C
Y
V
N
D
I
V
L
A
I
L
E
L
L
K
Y
-----
H
Q
R
V
L
Y
I
D
I
D
I
H
H
G
D
G
V
E
E
A
F
Y
----------------------------------
T
------
T
---------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
M
T
V
S
F
H
K
Y
G
--
E
Y
F
P
-----
G
--
T
-
G
D
--
L
--
R
--
D
---
I
G
AGK
G
K
Y
Y
A
V
N
Y
P
L
R
D
-----------------------------------------------------
G
-
I
D
--------------------------------------
D
E
S
Y
E
A
I
F
K
P
V
M
S
K
V
M
E
M
F
Q
P
S
A
V
V
L
Q
C
G
S
D
S
L
S
G
D
R
L
G
C
--
F
N
L
T
-----
I
K
G
H
A
K
C
V
E
F
V
K
S
F
-----
N
L
P
M
L
M
L
G
G
G
G
Y
T
I
R
N
-----
V
A
R
C
W
-
T
Y
E
T
A
V
A
L
D
T
E
--------
I
P
N
E
L
P
Y
N
D
--
Y
F
E
Y
F
-
G
P
D
F
K
L
H
I
S
P
S
-
N
M
---
T
N
Q
N
T
N
E
Y
L
E
K
I
K
Q
R
L
F
E
N
L
R
M
L
P
H
A
------------------------------------------------------------------------------------------------------------------------------------
143
HHSearch
56.26
18%
-17
- C3 -
-
5DC8
4
HDAC8_HUMAN
A:
[14-376]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
P
V
Y
I
Y
S
P
E
Y
V
S
M
C
--------------------
D
S
L
A
K
I
P
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
H
K
Q
-----
M
-
R
I
V
K
P
-----
K
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
S
------
Q
E
G
-------------------------
D
-----------------------
D
-
D
H
-----------
P
-
D
--------
S
I
E
Y
--
G
L
------------
G
Y
D
C
P
A
T
E
G
I
F
D
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
N
W
-
S
G
G
W
--
A
H
A
K
K
-----------------
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
-----
K
F
E
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
----------------------------------
F
------
T
---------------------------------------------------------------------------------------------------------------------------------------------------
S
K
V
M
T
V
S
L
H
K
F
S
-
P
G
F
F
P
-----
G
--
T
-
G
D
--
V
--
S
--
D
---
V
G
LGK
G
R
Y
Y
S
V
N
V
P
I
Q
D
-----------------------------------------------------
G
-
I
Q
--------------------------------------
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
P
M
C
S
--
F
N
M
T
-----
P
V
G
I
G
K
C
L
K
Y
I
L
Q
W
-----
Q
L
A
T
L
I
L
G
G
G
G
F
N
L
A
N
-----
T
A
R
C
W
T
Y
L
T
G
V
I
L
G
K
T
---------
L
S
S
E
I
P
D
H
E
--
F
F
T
A
Y
-
G
P
D
Y
V
L
E
I
T
P
S
-
C
R
---
P
D
R
N
E
P
H
R
I
Q
Q
I
L
N
Y
I
K
G
N
L
K
H
V
---------------------------------------------------------------------------------------------------------------------------------------
154
HHSearch
51.06
16%
-19
- C3 -
-
4BZ7
10
?
A:
[2-423]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
G
I
V
Y
G
D
Q
Y
R
Q
L
C
--------------------
C
S
S
P
K
F
G
D
R
Y
A
L
V
M
D
L
I
N
A
Y
K
L
I
P
E
L
------
S
R
V
P
P
LQWDS
P
S
R
M
Y
E
A
V
T
A
F
H
S
T
E
Y
V
D
A
L
K
K
L
Q
------
M
L
H
C
E
E
-----
K
----
E
----------------------------------
L
T
A
D
D
E
-
L
--------
L
----------
M
D
S
F
--
S
L
------------
N
Y
D
C
P
G
F
P
S
V
F
D
Y
S
L
A
A
V
Q
G
S
L
A
A
A
S
A
L
I
C
R
H
C
E
V
V
I
N
W
-
G
G
G
W
--
H
H
A
K
R
-----------------
S
E
A
S
G
F
C
Y
L
N
D
I
V
L
A
I
H
R
L
V
S
S
T
P
---
Q
T
R
V
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
E
A
F
W
----------------------------------
Y
------
S
---------------------------------------------------------------------------------------------------------------------------------------------------
P
R
V
V
T
F
S
V
H
H
A
S
-
P
G
F
F
P
-----
G
--
T
-
G
T
--
W
--
N
---IFL
N
G
AGR
G
R
F
S
A
F
N
L
P
L
E
E
-----------------------------------------------------
G
-
I
N
--------------------------------------
D
L
D
W
S
N
A
I
G
P
I
L
D
S
L
N
I
V
I
Q
P
S
Y
V
V
V
Q
C
G
A
D
C
L
A
T
D
P
H
R
I
--
F
R
L
T
NFYPS
L
S
G
Y
L
Y
A
I
K
K
I
L
S
W
-----
K
V
P
T
L
I
L
G
G
G
G
Y
N
F
P
D
-----
T
A
R
L
-
W
T
R
V
T
A
L
T
I
E
E
V
K
G
K
K
--
M
T
I
S
P
E
I
P
E
H
S
--
Y
F
S
R
Y
-
G
P
D
F
E
L
D
I
D
---
Y
F
P
--------
D
S
I
Q
K
H
H
R
R
I
L
E
Q
L
R
N
Y
A
D
L
N
K
----------------------------------------------------------------------------------------------------------------------------------
170
Fugue
50.72
19%
1
* C1 *
-
5G0J
9
?
A:
[17-772]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
G
K
S
K
A
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
W
D
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
-
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
V
T
E
D
E
L
L
L
V
H
T
-
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
E
E
L
K
T
L
A
E
K
Y
DS
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
NR
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
-
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
-----
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
P
K
-
G
G
------------
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
----
A
Q
G
R
L
V
L
A
L
E
G
GYN
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
D
P
C
P
H
L
P
S
S
G
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
YP
F
W
K
S
L
Q
T
F
E
G
G
P
L
S
--
E
V
S
P
L
P
A
P
V
C
A
E
V
K
V
S
S
P
--
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
S
HHPE-
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
------
P
------------------------------
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
I
K
S
S
--
E
H
--------
M
K
P
R
D
L
N
R
L
G
D
--
E
Y
N
S
I
F
I
-----------
S
N
E
------
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
-----------------
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
-
T
R
E
S
L
R
-
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
----------------------------------
E
DDS
V
--
L
Y
I
S
L
H
R
---
Y
E
D
GAFF
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
K
G
R
G
Y
N
V
N
I
P
WNG----
G
K
M
---
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
----
S
A
G
FD
A
A
R
G
D
P
L
G
--------
G
F
Q
V
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
LA
A
G
----
R
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
-
D
S
P
P
S
-----
L
--
D
-
H
L
--
T
--
P
--
L
---
K
T
---
S
A
T
V
S
I
N
N
V
L
R
A
H
APFWSSLRVNI
P
E
S
L
R
L
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
HHSearch
50.60
18%
7
- C3 -
-
1C3P
-
?
A:
[2-373]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
K
L
I
G
T
L
D
Y
G
K
Y
R
--
Y
----------------
P
K
N
H
P
L
K
I
P
R
V
S
L
L
L
R
F
K
D
A
M
N
L
I
D
E
-----
K
-
E
L
I
K
S
-----
R
P
A
T
K
E
E
L
L
L
F
H
T
E
D
Y
I
N
T
L
M
E
A
E
------
R
C
Q
----------
C
V
P
K
-------------------------------------
G
------------
A
----------
R
E
K
Y
--
N
I
G
-----------
G
Y
E
N
P
V
S
Y
A
M
F
T
G
S
S
L
A
T
G
S
T
V
Q
A
I
E
E
F
L
K
G
N
--
V
---
A
F
N
P
A
G
GM
H
H
A
F
K
-----------------
S
R
A
N
G
F
C
Y
I
N
N
P
A
V
G
I
E
Y
L
R
K
----
K
G
F
K
R
I
L
Y
I
D
L
D
A
H
H
C
D
G
V
Q
E
A
F
Y
----------------------------------
D
------
T
---------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
V
F
V
L
S
L
H
Q
S
P
-
E
Y
A
F
P
-----
F
E-
K
-
G
F
--
L
--
E
--
E
---
I
G
EGK
G
K
G
Y
N
L
N
I
P
L
P
K
-----------------------------------------------------
G
-
L
N
--------------------------------------
D
N
E
F
L
F
A
L
E
K
S
L
E
I
V
K
E
V
F
E
P
E
V
Y
L
L
Q
L
G
T
D
P
L
L
E
D
Y
L
S
K
--
F
N
L
S
-----
N
V
A
F
L
K
A
F
N
I
V
R
E
V
F
-----
G
E
G
V
Y
L
G
G
G
G
Y
H
P
Y
A
-----
L
A
R
A
W
T
L
I
W
C
E
L
S
G
R
E
V
---------
P
E
K
L
N
N
K
A
K
E
L
L
K
S
I
D
F
E
E
F
D
D
E
V
D
R
S
-
Y
M
L
--
E
T
L
K
D
P
W
R
G
G
E
V
R
K
E
V
K
D
T
L
E
K
A
K
A
-------------------------------------------------------------------------------------------------------------------------------------
173
Fugue
47.42
16%
-57
- C3 -
-
4BZ7
6
?
C:
[2-446]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
G
I
V
Y
G
D
Q
-----
Y
R
Q
L
C
C
S
S
---
P
K
F
G
D
R
Y
A
L
V
M
D
L
------
I
N
A
Y
K
L
-----
I
P
E
L
S
R
V
P
P
L
Q
W
D
S
P
S
R
M
Y
E
A
V
T
A
F
H
S
T
E
Y
V
D
A
L
K
K
L
Q
M
L
H
C
-
E
E
L
T
A
--------
D
D
E
L
L
M
D
S
F
S
---------
L
-----------
N
Y
D
C
P
G
F
P
S
V
F
D
Y
S
L
A
A
V
Q
G
S
L
A
A
A
S
A
L
I
C
R
H
C
E
--
V
V
I
N
W
G
G
G
--
W
H
H
A
K
R
S
E
A
S
----------------
G
F
C
Y
L
N
D
I
V
L
A
I
H
R
L
V
S
S
------
T
R
V
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
E
A
F
W
----------------------------------
Y
------------------
S
----
P
R
V
V
T
F
S
V
H
H
A
S
P
G
F
F
P
G
T
G
T
W
----------------------------------------------------
N
M
K
L
P
I
F
--------
L
N
G
A
G
R
G
R
F
S
A
F
N
L
P
L
E
-----------------
E
G
I
N
D
L
D
W
S
N
A
I
G
P
I
L
D
S
L
N
-
I
V
I
Q
P
S
Y
V
V
V
Q
--
C
-
G
A
--
D
--
C
LA
T
---
D
P
---
H
R
I
F
R
L
T
N
F
Y
P
S
E
-----------
C
S
L
S
G
Y
L
Y
A
I
K
K
I
L
S
W
K
V
P
T
L
I
L
G
G
G
G
Y
N
F
P
D
T
A
R
L
W
T
R
V
T
A
-
L
T
I
E
E
V
K
G
K
K
M
T
I
S
P
E
I
P
E
H
S
Y
F
S
R
Y
G
P
D
F
E
L
D
I
D
Y
F
P
H
E
T
L
D
S
I
Q
K
H
H
R
R
I
L
E
Q
L
R
N
Y
A
D
L
N
K
L
I
Y
D
Y
D
Q
V
Y
Q
L
Y
N
L
T
G
M
G
S
L
V
P
-----
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Fugue
45.42
21%
-44
- C3 -
-
1ZZ1
5
HDAH_ALCSD
A:
[2-368]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
G
Y
V
W
N
T
L
Y
G
W
------
V
D
T
G
T
G
-----
S
L
A
A
A
N
L
T
A
R
M
Q
P
I
S
H
H
L
A
H
P
D
T
K
R
R
F
H
E
L
V
C
A
S
G
-
Q
I
E
H
L
T
P
I
A
A
V
A
--------
A
T
D
A
D
I
L
R
A
H
S
A
A
H
L
E
N
M
K
R
V
S
N
LPTGGDTG
D
G
I
T
M
M
G
N
G
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
--
H
H
A
P
-----------------
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
---
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
NDPS
V
L
T
I
S
L
H
QHLCFPPDSGYSTERGAGNGHGY
N
------
I
N
V
P
L
P
P
GSG
N
A
A
----
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
-------
S
G
F
DAS
M
L
D
P
L
A
R
M
M
V
------
T
A
D
G
F
R
Q
M
A
R
R
----
T
I
D
--
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
--
T
G
VRSL
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
L
L
D
A
E
R
A
A
I
E
E
I
V
-
P
L
L
A
D
-----
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Fugue
44.80
21%
-2
- C3 -
-
3MEN
12
APHA_BURP1
A:
[21-359]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
M
L
T
Y
F
H
P
D
Q
S
L
H
H
P
R
T
Y
F
S
R
G
R
M
R
M
P
QEV
P
E
R
A
A
R
L
-----
V
A
A
A
F
A
M
G
F
P
V
R
E
P
D
D
F
G
I
A
P
I
A
A
V
H
D
T
H
Y
L
R
F
L
E
T
V
H
R
E
W
K
A
M
P
E
D
W
GD
E
A
M
S
NI
F
V
R
E
P
N
A
L
R
G
V
L
A
Q
A
A
R
H
L
A
-----------
D
G
S
C
P
V
G
E
H
T
W
R
A
A
Y
W
S
A
Q
S
A
L
A
A
A
A
A
V
R
D
G
A
-
P
A
A
Y
A
L
C
R
P
P
G
--
H
H
A
R
V
-----------------
D
A
A
G
G
F
C
Y
L
N
N
A
A
I
A
A
Q
A
L
-----
R
A
R
H
A
R
V
A
V
L
D
T
D
M
H
H
G
Q
G
I
Q
E
I
F
Y
----------------------------------
A
RRD
V
L
Y
V
S
I
H
G
D
P
---
T
N
F
----
Y
P
A
V
A
G
F
D
D
E
R
G
A
G
E
G
L
G
Y
N
V
N
L
P
M
P
HGSS
E
A
A
F
---
F
E
R
V
D
D
A
L
R
E
------
L
R
R
F
A
P
D
A
L
V
L
SLGF
D
V
Y
--
R
D
D
P
Q
S
Q
V
--------
A
V
T
T
D
G
F
G
R
L
G
H
L
I
G
A
-
L
--
R
L
----
P
T
V
I
V
Q
E
G
G
Y
H
-
I
E
S
L
E
A
N
A
R
S
F
F
G
G
F
G
-
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
44.53
32%
-67
- C4 -
-
1ZZ0
4
HDAH_ALCSD
C:
[63-193]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
--------
H
L
E
N
--------
M
K
R
--
V
S
N
L
P
T
G
G
D
T
----
G
-----------
D
G
I
T
M
M
G
N
G
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
--
H
H
-----
A
P
H
N
A
A
------------
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
---
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
----------------------------------
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
43.95
32%
-65
- C4 -
-
1ZZ3
4
HDAH_ALCSD
A:
[63-193]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
--------
H
L
E
N
--------
M
K
R
--
V
S
N
L
P
T
G
G
D
T
----
G
-----------
D
G
I
T
M
M
G
N
G
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
--
H
H
-----
A
P
H
N
A
A
------------
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
---
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
----------------------------------
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------