@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_02_0540: (2018-03-07 )
MIKWNELRLQRRTSQTPLEENRSCSSDESFSLASIWTPNREQELHVLEDRISFSVFELEGVYLNPLLVSWSKPRLRSLVADVAATWAKEGPYSAEFDCISSRLFDAISTEQTCQLRSTCLLSVRQWLGSAQHRWDVTCVLIALLTVSILCIVFLAVFGRTQAVCVVFSTMLSVAVVLMYVVAVFVLHHNTYADAASRYFREEVVRAAQKKMEEEEMAEKRDVGSRSGYRHRGAVKTSRDAADNGCRGYTAGDDDTGVDDEYMEDEISIAVRNLRALTEGSTHPVTNAPPYYRLSDRPHSGKCDNGGAGGGFEDDMTLADGNYASLTSRSLQAGDKAKQQFEEDRENRLLLSRGTFEQHQAHMDQQESHRVHERMNAQQALRPTKQATPSSTSGATGAQTRPSTADSGGSGRQEQLTRGGRDGKKIVMQEQQPLQQLADLPENVNVTALLFCRNAGVLSQVASSLWERNFMLLRVSNLQALNKFNRGSERFGVVLIHAPDVAEGSAELETALSWLQVERRPVFFFSRSAMAYPASVPFSARLLVPFSSTSLNALLLAGIGVESEHGCVSSPLLPQQEQERHQQQCPSQPFQVPPYTLGRRLGGGAFGNVFEAEMEHTGARCAVKRMYLKEDSNQDEEQQVNSGVAGACAGGSGTLAAGANSATSPRAAAVEEEVGGATTAVGSQLRDIAQEVEIMSSLQHPNIVRYYYCERDDNCISIFMELCTGGSLRSLIHSGKLVNPPEIKHLLREIISAVSYLHNMRIVHRDLKPDNVLFRQGHIKITDFGTAVHKHGGDLRLIRGTFAYMAPEILVGDPYGRACDVWSIGCIAAEVLSVELPQHALGLPEMCDYYRAMGENSELPIECDVPGVRDFLLACLQRNPNQRSTAAELFYHPILQARDTSIHDWMVEVVARRRRMQQQQQALHRNGLGSRTGGGAGGLGGNHQVSSNGPNNNGGMNCANAGDRFDLHSVGSAQSLDSSKLV
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550--.........560.......570.......580.......590-.-----......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.....-..700.......710.......720.......-730.--.-.----..-..----740.......750......-.760.......770.--.-----.----.----...780......-.--790-.--....--...800.......810----...--......820.......830.......840.......850.-.-..-.-..860..-...-..870.......880-----.-----......890.......900-----------------------.......910.......920.......930.......940.......950.......960.......970.......980
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MIK
W
N
E
L
R
L
QRRTSQTPLEENRSCSSDESF
S
L
A
S
IWTPN
R
E
Q
E
L
H
V
L
E
D
RI
S
F
S
V
F
E
L
E
G
V
Y
LN
P
L
LVSWS
K
P
R
L
R
S
L
V
A
D
V
A
A
T
W
AKEGPYS
A
E
F
D
C
I
S
S
R
L
F
D
A
IS
T
E
Q
T
C
Q
L
R
S
T
C
L
L
S
V
R
Q
W
L
GSAQHR
W
D
V
T
C
V
L
I
A
L
L
T
V
S
I
L
C
I
V
F
L
A
V
FGR
T
Q
A
V
C
V
V
F
S
T
M
L
S
V
A
V
V
L
M
Y
V
V
A
V
F
V
LHHN
T
Y
A
D
A
A
S
R
Y
F
R
E
E
V
V
R
A
A
Q
K
K
M
E
E
E
E
M
A
E
K
RDVGSRSGYRHRGAVKTSRDAADNGCRGYTAGDDDTGV
D
D
E
Y
M
E
D
E
I
S
I
A
V
R
N
L
R
A
L
TEGSTHPVTNAPP
Y
Y
RLSDRPHSGKCDNGGAGGGFEDD
M
T
LADGN
Y
A
S
L
T
S
R
SLQA
G
D
K
A
K
Q
Q
F
E
E
D
REN
R
L
L
LSRGT
F
E
Q
H
Q
A
HM
D
Q
Q
E
S
H
R
V
H
E
R
M
N
A
Q
Q
ALRPTKQATPSSTSGATGAQTRPSTADSGGSG
R
Q
E
Q
L
T
RGGRDG
K
K
I
V
M
Q
E
Q
Q
P
L
Q
Q
L
ADLPENV
N
V
T
A
L
L
F
CRNA
G
V
L
S
Q
V
A
S
S
L
W
ER
N
F
M
L
L
R
VS
N
L
Q
A
L
N
K
FNRGS
E
R
F
G
V
V
L
I
HAPDVAE
G
S
A
E
L
E
T
A
L
S
W
L
Q
VERR
P
V
F
F
FSRSAMAYPASVPF
S
A
R
L
L
V
P
FSSTSL----
N
A
L
L
L
A
GIGVESEHGCVSSPLL
P
Q
Q
E
Q
E
R
H
Q
Q
QCPSQPFQVP-
P
-----
Y
T
L
G
RRLGGGAFG
N
V
F
E
A
E
M
E
HT
G
A
R
C
A
V
K
R
M
Y
LKEDSN
Q
D
E
E
Q
Q
V
NSGV
A
G
ACAGGSG
T
L
AAGANSATSP
R
A
A
A
V
E
E
EVGGA
T
T
A
V
G
S
Q
L
R
D
I
A
Q
E
V
E
I
M
S
SL-QHP
N
I
V
R
Y
Y
Y
CERDD
N
C
I
S
I
F
M
E
LCTG
G
S
L
R
S
-
L
I
HS--G-K----LV-N
P
----
P
E
I
K
H
L
L
R
E
I
I
S
A
V
S
Y
L
H
N
-
M
R
I
V
HRDLKPD
N
V
L
F
--R-----Q----G----
H
I
K
I
TDF
G
T
A
V
H
-K--HG--G--
D
L
R
L
--
I
R
G
T
F
A
YMAP
E
I
L
V------GDP--YGRACDV
W
S
I
G
C
I
A
A
E
V
L
S
VEL
P
Q
H
ALG
L
P
E
M
C
D
Y
Y
R
AMG-E-NS-E-L
P
I
ECDV-P
G
V
-
R
D
F
L
L
A
C
L
QRNPNQR-----
S
-----
T
A
A
E
L
F
Y
H
P
I
LQARDT
S
I
H
-----------------------
D
W
M
V
E
V
V
A
R
R
R
R
M
Q
Q
Q
Q
Q
A
L
H
RNGLGSRTGGGAGGLGGNHQVSSNGPNNNGGMNCANAGDRFDLHSVGSAQSLDSSKLV
48
Fugue
70.83
19%
-25
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
----
P
I
G
R
L
L
F
R
E
F
C
A
--
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
----
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-------------
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
VTKNT
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
------------------------------------------------
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
-
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
-
H
I
Y
H
MG
Q
-
A
----
G
F
-
P
E
----
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
-----
H
----
G
----
H
I
R
I
S
D
L
G
L
A
V
H
V
P
--
E
G
--
Q
--
T
I
K
G
--
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
------
N
E
R
--
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
-
K
-
E
V
-
P
-
E
E
Y
S
E
R
F
S
P
Q
A
-
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
LGCRG
G
-----
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
GMLEPPFKPDPQAIYCE
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
-------------------------------------------
39
HHSearch
68.98
29%
-69
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[12-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
-
Y
-----
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
---------------------------------------------
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
--
K
-
E
----
S
L
-
T
E
----
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D----
R
NVP
K
P
----
R
I
K
I
I
D
F
G
L
A
H
K
-
I
--
D
F
G-
N
--
E
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
-
Y
-
E
F
-
E
D
E
Y
F
S
N
T
S
-
A
L
A
-
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
-----
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-----------------------------------------------------------------------------------------------------------
29
HHSearch
67.30
29%
-72
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[10-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
-
Y
-----
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
---------------------------------------------
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
--
K
-
E
----
S
L
-
T
E
----
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D----
R
NVP
K
P
----
R
I
K
I
I
D
F
G
L
A
H
K
-
I
--
D
F
G-
N
--
E
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
-
Y
-
E
F
E
D
-
E
Y
F
S
N
T
S
-
A
L
A
-
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
-----
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-----------------------------------------------------------------------------------------------------------
42
HHSearch
67.08
29%
-72
- C1 -
-
4PF4
6
DAPK1_HUMAN
A:
[11-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
-
Y
-----
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
---------------------------------------------
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
--
K
-
E
----
S
L
-
T
E
----
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D----
R
----
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
-
I
--
D
F
--
G
N
-
E
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
-
Y
-
E
F
E
D
-
E
Y
F
S
N
T
S
-
A
L
A
-
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
-----
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------------------------------------------------
43
HHSearch
65.90
28%
-71
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
D
-
N
-----
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
A
-------------------------------------------------
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
--
R
-
E
----
F
Y
-
S
E
----
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
-
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
--
A
S----
K
AKG-
A
----
A
V
K
L
A
D
F
G
L
A
I
E
-
V
--
N
D
--
S
E
-
A
W
H
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
P
--
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
A
-
Y
-
D
Y
-
P
S
P
E
W
D
T
V
T
-
P
E
A
-
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
-----
I
-----
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
----------------------------------------------------------------------------------------------------------
22
HHSearch
64.25
30%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[3-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
-
E
-----
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
-------------------------------------------------
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
--
R
-
E
----
Y
Y
-
S
E
----
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
SKSK-
G
----
A
----
A
V
K
L
A
D
F
G
L
A
I
E
-
V
--
Q
G
--
D
QQ
A
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
--
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
-
Y
-
D
F
P
S
-
P
E
W
D
T
V
T
-
P
E
A
-
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
-----------------------------------------------------------------------------------------------------------
40
HHSearch
64.19
27%
-70
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[7-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
-
E
-----
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
------------------------------------------------
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
-
H
L
S
R
--
E
-
R
----
V
F
-
S
E
----
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
-----
D
----
G
----
H
I
K
I
T
D
F
G
L
C
K
E
-
G
--
I
K
DG
A
--
T
M
K
T
--
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
N
D
--
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
----
E
I
-
R
-
F
P
-
R
T
L
G
-
P
E
A
-
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
-----
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
-----------------------------------------------------------------------------------------------------------
25
HHSearch
63.89
27%
-70
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
-
V
-----
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
----------------------------------------------
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
--
R
-
A
D
A
G
F
V
Y
-
S
E
----
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
SKEN-
S
----
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
-
L
--
G
E
--
S
G
L
V
A
G
G
--
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
--
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
L
-
F
E
G
I
I
K
G
K
-
Y
-
K
M
N
P
-
R
Q
W
S
H
I
S
-
E
S
A
-
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
-----
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----------------------------------------------------------------------------------------------------------
35
HHSearch
63.74
29%
-83
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-
Y
-----
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
---------------------------------------------------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
--
T
------
R
M
-
N
E
----
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
--
T
H----
D
----
G
----
R
V
K
L
S
D
F
G
F
C
A
Q
-
V
--
S
K
--
E
VP
R
R
K
S
--
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
-
P
-
P
R
-
L
-
K
N
L
H
K
V
S
-
P
S
L
-
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
-----
A
-----
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
----------------------------------------------------------------------------------------------------------
28
HHSearch
63.23
27%
-46
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[93-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
-
K
-----
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
P
-------------------------------------------
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
--
K
-
V
----
A
L
-
S
E
----
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D-
D
-----
N
----
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
-
L
--
E
P
--
G
E-
K
L
R
E
--
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
--
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
-
Y
-
Q
F
-
S
S
P
E
W
D
D
R
S
-
S
T
V
-
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------
33
HHSearch
62.49
27%
-47
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[93-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
-
K
-----
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
S
P
-------------------------------------------
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
--
K
-
V
----
A
L
-
S
E
----
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D----
N
----
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
-
L
--
E
P
--
G
E-
K
L
R
E
--
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
--
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
-
Y
-
Q
F
-
S
S
P
E
W
D
D
R
S
-
S
T
V
-
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------
24
HHSearch
61.67
27%
-65
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
-
V
-----
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
----------------------------------------------
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
--
R
-
A
D
A
G
F
V
Y
-
S
E
----
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
SKEN-
S
----
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
-
L
--
G
E
--
S
GL
V
A
G
G
--
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
--
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
L
-
F
E
G
I
I
K
G
K
-
Y
-
K
M
N
P
-
R
Q
W
S
H
I
S
-
E
S
A
-
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
-----
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----------------------------------------------------------------------------------------------------------
26
HHSearch
59.42
28%
-39
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
T
-----
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
---------------------------------------------------
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
-
R
I
I
D
--
E
S
Y
----
N
L
-
T
E
----
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
-
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
D----
A
----
K
----
Q
I
K
I
I
D
F
G
L
A
R
R
-
Y
--
K
P
--
R
E
-
K
L
K
V
--
N
F
G
T
P
E
F
L
A
P
E
V
V
N
------
Y
D
F
--
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
R
-
W
-
D
L
-
E
D
E
E
F
Q
D
I
S
-
E
E
A
-
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
-----
I
-----
S
A
S
E
A
L
K
H
P
W
L
S
D
H
-----------------------------------------------------------------------------------------------------------
49
Fugue
58.66
18%
-8
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
ADDA
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
-
L
-----
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
--
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
-----
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
--
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
-
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
-
H
I
Y
N
--
V
-
D
----
E
D
-
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
-
D
-----
D
----
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
--
K
A
--
G
--
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
------
G
E
E
--
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
-
L
-
E
Q
-
A
-
V
T
Y
P
D
K
F
S
P
A
S
-
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
LGFRD
G
-----
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
---
W
-----------------------
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
G
A
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
----------
34
HHSearch
57.62
29%
-74
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
D
-----
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
---------------------------------------------------
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
-
I
Y
H
V
--
T
-
G
----
P
L
-
S
E
----
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T-
D
-----
N
----
G
----
H
V
K
L
A
D
F
G
V
S
A
Q
-
I
--
T
A
--
T
IA---
A
--
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER---
K
G
G
--
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
F
L
M
T
K
S
N
-
F
-
Q
P
P
K
L
K
D
K
M
K
W
S
-
N
S
F
-
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
-----
P
-----
T
A
E
K
L
L
Q
H
P
F
V
T
Q
------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
57.61
31%
-60
- C1 -
-
2XUU
1
DAPK1_HUMAN
A:
[55-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
--
K
-
E
----
S
L
-
T
E
----
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DRNVP
K
----
P
----
R
I
K
I
I
D
F
G
L
A
-
H
-
K
ID
F
G
--
N
--
E
F
K
N
--
I
F
G
T
P
A
F
V
A
P
E
I
V
N
------
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
-
Y
-
E
F
-
E
-
D
E
Y
F
S
N
T
-
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
-----
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
---------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
57.17
30%
-58
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[55-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
--
K
-
E
----
S
L
-
T
E
----
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DRNVP
K
----
P
----
R
I
K
I
I
D
F
G
L
A
-
H
-
K
ID
F
G
--
N
--
E
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
-
Y
-
E
F
-
E
-
D
E
Y
F
S
N
T
-
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
-----
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
---------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
56.93
30%
-61
- C1 -
-
4B4L
2
DAPK1_HUMAN
A:
[57-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
--
K
-
E
----
S
L
-
T
E
----
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DRNVP
K
----
P
----
R
I
K
I
I
D
F
G
L
A
-
H
-
K
ID
F
G
--
N
--
E
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
-
Y
-
E
F
-
E
-
D
E
Y
F
S
N
T
-
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
-----
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
---------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.73
30%
-65
- C1 -
-
4TL0
2
DAPK1_HUMAN
A:
[57-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
--
K
-
E
----
S
L
-
T
E
----
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DRNVP
K
----
P
----
R
I
K
I
I
D
F
G
L
A
-
H
-
K
ID
F
G
--
N
--
E
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
-
Y
-
E
F
-
E
-
D
E
Y
F
S
N
T
-
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
-----
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
---------------------------------------------------------------------------------------------------------
46
Fugue
56.67
21%
12
- C1 -
-
1KOB
1
?
A:
[23-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
-----
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
---------------------------------------------------
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
--
D
-
Y
----
K
M
-
S
E
----
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
--
E
-----
T
KKA-
S
----
S
V
K
I
I
D
F
G
L
A
T
K
L
N
--
P
D
--
E
--
I
V
K
V
--
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
P
--
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
-
F
D
-
E
-
D
A
F
S
S
V
S
-
P
E
A
-
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
-----
L
-----
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
-----------------------
S
-----
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
----------------
3
PsiBlast_PDB
52.67
33%
-20
- C1 -
-
4BHN
1
M3K5_HUMAN
A:
[79-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
KW
G
-
P
----
L
K
D
N
E
----
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
--
N
TY---
S
----
G
----
V
L
K
I
S
D
F
G
T
S
K
R
-
L
------------
E
--
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
------
K
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
V
H
P
-
E
-
I
P
-
E
S
M
S
-
A
E
A
-
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
-----
C
A
N
D
L
L
V
-----------------------------------
D
E
F
L
K
V
-------------------------------------------------------------------------
10
PsiBlast_PDB
48.37
33%
-14
- C1 -
-
4BIE
1
M3K5_HUMAN
A:
[65-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
KW
G
-
P
----
L
K
D
N
E
----
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
--
N
TY---
S
----
G
----
V
L
K
I
S
D
F
G
T
S
K
R
-
L
--
A
G
--------
E
--
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
------
K
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
V
H
P
-
E
-
I
P
-
E
S
M
S
-
A
E
A
-
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
-----
C
A
N
D
L
L
V
-----------------------------------
D
E
F
L
K
V
-------------------------------------------------------------------------
4
PsiBlast_PDB
47.09
35%
-21
- C1 -
-
5V24
1
M3K5_HUMAN
A:
[55-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
KW
G
-
P
----
L
K
D
N
E
----
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
--
N
TY---
S
----
G
----
V
L
K
I
S
D
F
G
T
S
K
R
-
L
---------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----------
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
--
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
V
H
P
-
E
-
I
P
-
E
S
M
S
-
A
E
A
-
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
-----
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
46.97
35%
-34
- C1 -
-
5UOR
1
M3K5_HUMAN
A:
[55-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
KW
G
-
P
----
L
K
D
N
E
----
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
--
N
TY---
S
----
G
----
V
L
K
I
S
D
F
G
T
S
K
R
-
L
---------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----------
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
------
A
M
F
K
V
G
M
F
-
K
V
H
P
-
E
-
I
P
-
E
S
M
S
-
A
E
A
-
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
-----
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
46.86
33%
-16
- C1 -
-
4BIC
1
M3K5_HUMAN
A:
[65-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
KW
G
-
P
----
L
K
D
N
E
----
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
--
N
TY---
S
----
G
----
V
L
K
I
S
D
F
G
T
S
K
R
-
L
--
A
G
--------
E
--
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
------
K
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
V
H
P
-
E
-
I
P
-
E
S
M
S
-
A
E
A
-
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
-----
C
A
N
D
L
L
V
-----------------------------------
D
E
F
L
K
V
-------------------------------------------------------------------------
9
PsiBlast_PDB
46.78
33%
-18
- C1 -
-
4BID
1
M3K5_HUMAN
A:
[65-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
KW
G
-
P
----
L
K
D
N
E
----
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
--
N
TY---
S
----
G
----
V
L
K
I
S
D
F
G
T
S
K
R
-------------
E
E
--
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
------
K
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
V
H
P
-
E
-
I
P
-
E
S
M
S
-
A
E
A
-
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
-----
C
A
N
D
L
L
V
-----------------------------------
D
E
F
L
K
--------------------------------------------------------------------------
7
PsiBlast_PDB
46.15
33%
-17
- C1 -
-
4BIB
3
M3K5_HUMAN
A:
[65-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
KW
G
-
P
----
L
K
D
N
E
----
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
--
N
TY---
S
----
G
----
V
L
K
I
S
D
F
G
T
S
K
R
-------------
E
E
--
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
------
K
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
V
H
P
-
E
-
I
P
-
E
S
M
S
-
A
E
A
-
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
-----
C
A
N
D
L
L
V
-----------------------------------
D
E
F
L
K
--------------------------------------------------------------------------
6
PsiBlast_PDB
45.69
35%
-12
- C1 -
-
2CLQ
1
M3K5_HUMAN
A:
[68-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
KW
G
-
P
----
L
K
D
N
E
----
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
--
N
TY---
S
----
G
----
V
L
K
I
S
D
F
G
T
S
K
R
-
L
--
A
G
-------
E
T
--
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
------
K
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
V
H
P
-
E
-
I
P
-
E
S
M
S
-
A
E
A
-
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
-----
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------