@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_03_0330: (2018-03-07 )
MLPADDELAASEGSSHRQRQPQCRSGIEGDSTSSSRNDAGNSVNSGSRSSSGGGDRGATARGPFVDMEGSSGEANVPIGRTLSDDGQPQNARPRSEDPPAMASLLSRHCLDDAVAVDTVEGGDSTDNVDDVRPGSPFLHRRNRLRGPPNATVMAPDAASRRAAGSRHSSKVDLLEAQEDPPMLSSRQRLLRPVSSDSIVFSIVSSNSSGDELDGQGSEAARARLHAGDGDDVSSLLPSTSALSGPASSNALLCPRTVYDADDNGSGTGKDGVDSGADSMHSSPVAVTLWGVDRDLRRKRIKKVSHYILGPLLGEGSYGVVRDCIDLNTDNADRRFSRCAIKIINGNYAKLDTSAAKPSKASSTLAAATEDGTDGGARAGTRGTLKRTSGIQYRREEDLKRQETFQREMRNLQRFHSKNIIRALDAFTRYSKEYVVMPIAICSLRQLVQQMLRTRWREAVREWRRAQRRLQRKQRHKRGHFATSVSGDQTQTPSQPSPWLPMVPSAVEELDMDELAFMTDGERDGGDDTDGISASQPHSSSDGDDGVAAERDSEASMVDHDEESQRQHSATSSVTATAVGGRVAAAAAAVSERGPSGQSRLPPRVAFNGASSTATTTHIIDRYTSHSNGSPPSQSPRQRSGEHFPTFAGGHHHGGGNGSWGDDVSDGSSASTTGAHNGITVMSATPPALSTAELPMECDDLVGSGANGADGRPPATVSPAPAPAASTQHIRPHMSLPVCSPTLLKGIFYQLMSGVAYLHQQHLAHNDIKPSNVLLFEDGTVKLADLGSVSDTYNDQGSPLCASPELCKYFYGAATPPASFSQSAQHVGRDAAQSSDMWCCGLMLYYLITGKPGPLPVQLRYFRALNSKQAHQPFRPFAPHGDSGRAALPPVVTRYQLYREIAQQTTPVDLGGLPDMVAPDVGNDVLLSSSPMLAKGEAPHGDSVDDAATSSYPPNGVRHLLAGLLELDPLRRLTAEQALRHPWLRMAFRSKTSETSSSNTISQTSAPNSNGGQQDDAQNQQQQLKAPSKQAMEEAIQRDVARRVMESRHVQHMLRLDRQRHLQFVADCCNMLNLAIPPEIIKVHPEAPYHEDNGASVCSSSPPALQVYRPNSMAAAAAAVSGRNTRLGRPSAGANAPGPRGSTGGSEWSVTSRNSHNSAVAGIVLRDDMRPRVMPPGCVDTDLFLPPSEEDYYEQKSGKAEFDVRVLRRKPLLMAQLDEYFHNVVLVQCGYRTGPDPNYQAMRLRAVPIEDESGGGGSGGSQGGTQQPAVMILPGACGNVCRRSTSLGLSSMPVAAALAGNSSDDGGTDGANSRGGSVDVWAAGPRHNPRTHVDDHREVVAAASSAGAVAGRGANLSRTSAAAGRSLIGTSPPGAAAPSRPSAAGGTGSRAPDAGSHPILYCGRGSTGGSGNGSASRRVAGRGRGRGQRDASESPSEEEANVAMRESSKCLCGLV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650..---.....660.......670....-----...680.......690.......700...-----------....710....--...720.......730-..--.----....740-......---.750.......760.......770..---....-------------.780....-..---.790-----..-----------.......-800........810.---......820.......830.......840......-.850.......860.......870.......880....--...890--.......900.--......910.....-..920.......930.......940.......950...-....960.......970-----.......980.......990.......1000-.-......1010......1020......1030.----......1040.......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLPADDELAASEGSSHRQR
Q
P
Q
CRSGIEGDSTSSSRNDAGNSVNSGSRSSSGGGDRGATARG
P
F
V
DMEGSSGEANVPIGRTLSDDGQPQNARPRSED
P
P
A
M
A
S
L
L
S
R
HCLDDA
V
A
V
D
TVEGGDSTDNVDDVRPGS
P
F
L
H
R
R
NRLRGPPN
A
T
V
MAPDAASRRAAGSRHSSK
V
D
L
L
EAQEDPP
M
L
S
S
R
Q
R
L
LRPVSSD
S
I
V
F
S
I
VSSNSSGDELDGQGS
E
A
A
R
A
R
LHAGDG
D
D
V
S
S
L
LPSTSALSGPASSN
A
L
LCPRTVYDADDNGSGTGKDGVDSGADSMHSS
P
V
A
V
T
L
WGV
D
R
D
L
R
R
K
R
I
K
K
V
S
H
Y
I
L
G
P
LLGEGS
Y
G
V
V
R
D
C
IDLNTD
N
A
D
R
R
F
S
R
C
A
I
K
I
ING
N
Y
A
KLDTSAAKPSKASS
T
L
A
AATEDGTDGGARAGTRGTLKRTSGIQ
Y
R
R
E
E
D
L
K
R
Q
E
T
F
Q
R
E
M
R
N
L
Q
R
F
H
S
K
N
I
I
R
A
L
D
A
F
T
RYSK
E
Y
V
V
M
P
I
A
I
C
S
L
R
Q
L
V
Q
Q
M
L
R
T
R
W
R
E
A
V
R
E
W
R
R
A
Q
R
R
L
Q
R
K
Q
R
HKRGHFATSVSGDQTQTPSQPSPWLPMV
P
S
A
V
E
EL
D
M
D
E
L
A
F
MTDGERDGGDDTDGISASQPHSSSDGDDGVAAERDSEASMVDH
D
E
E
S
Q
R
Q
HSATS
S
V
T
A
TAVGG
R
V
A
A
A
A
A
A
V
SERGPSGQSRLP
P
R
V
A
FNGASST
A
T
T
T
H
I
I
D
RYTSHSNGSPPSQSPRQRSGEHFPTFAGGHHHGG---GNGSWGDDVSDGSSASTTGAHN-----
G
I
T
V
M
SATPPALSTAELPM
E
C
D
D
L
VGSGA-----------NGADGRPPATV--SPAPAPAASTQHIRPH-MS--L----PVC
S
P
T
L
-
L
K
G
I
F
Y
---
Q
L
M
S
G
V
A
Y
L
H
Q
Q
H
L
AHNDIKPS
N
V
L
L
---FEDG-------------
T
V
K
L
A
DLG-SV---SD-------TY-----------NDQGSPL-CA-
S
P
E
L
C
K
Y
F
YGAA---TPP
A
S
F
S
Q
S
A
Q
H
VGRDAAQSSD
M
W
C
C
G
L
M
L
Y
Y
L
I
T-GKPGP
L
P
V
Q
L
R
Y
F
R
ALNSKQAHQPFRPFAPHGDSGRAA--L
P
P
V
V
T
--
R
Y
Q
L
Y
R
E
I
A
Q
Q--TTPVDLGGLPDMVA-PDVGN
D
V
LLSSSPMLAKGEAPHGDSVDDAATSSYP
P
N
G
-
V
R
H
L
L
A
G
L
L
E
L
D
P
L
R
R
L
-----
T
A
E
Q
A
L
R
H
P
W
L
R
M
A
F
RSKTSETSSSNTISQ--T-SAPNSNGGQQD
D
A
Q
N
Q
Q
Q
Q
LKAP
S
K
Q
A
-
M
E
E
----
A
I
Q
R
D
V
A
R
-
R
V
M
E
S
R
H
V
Q
H
M
L
R
L
D
R
Q
R
H
L
Q
F
V
A
D
C
C
N
M
LNLAI
P
P
E
I
I
K
VHPEAPYHEDNGASVCSSSP
P
A
L
Q
V
YRPNS
M
A
A
A
A
A
AVSGRNTRLGRPSAGANAPGPRGSTGGS
E
W
S
V
TSRNSHNS
A
V
A
G
I
V
LRDDMRPRVMPPGCVDTDLFLPPS
E
E
D
Y
Y
E
QKSGKA
E
F
D
V
R
V
L
R
RK
P
L
L
M
A
Q
L
D
E
Y
F
H
N
V
V
L
V
Q
CGYRTGPDPNY
Q
A
M
R
L
R
A
V
PIEDESGGGGSGGSQGGTQQ
P
A
V
M
I
LPGA
C
G
N
V
C
R
R
S
TSLGLSSM
P
V
A
A
A
LAGNSSDDGGTDGANSRGG
S
V
D
V
W
AAGPRHNPRTH
V
D
D
H
R
E
V
V
A
AASSAGAVAGRGANLSRTSAAAGRSLIGTSPPGAAAPSRPSAAGGTGSRAPDAGSH
P
I
L
Y
CGRGSTGGSGNGSASRRVAGRGRGRGQRDASESPS
E
E
E
A
N
V
A
M
RESSKCLCGLV
51
Fugue
71.04
16%
-17
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
--
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
-----
A
P
F
Q
E
F
L
D
-
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
---
G
K
L
Y
A
C
K
K
L
N
----
K
K
R
L
K
K
R
K
-----
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
R
F
----
I
V
S
L
A
Y
-----------
A
F
E
T
K
T
D
L
C
L
V
--
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
--
N
----
P
G
F
Q
E
P
R
-
A
I
F
Y
T
A
---
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
---
D
D
D
G
-------------
N
V
R
I
S
D
L
G
-
L
A
---
V
E
L
K
AGQT
K
T
K
-----------
G
Y
A
G
T
P
G
-
F
M
-
A
P
E
L
L
L
----------------------
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
-
A
R
G
-----------------------
P
F
R
A
R
G
E
K
----------
V
E
--
N
K
E
L
K
Q
R
V
L
E
Q
--
A
V
T
Y
------------------------------------------
P
D
K
F
S
P
A
-
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
GFRDG
S
C
D
G
L
R
T
H
P
L
F
R
----
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
--
P
-
F
V
P
D
S
R
T
V
Y
A
K
N
G
A
F
S
G
V
A
F
E
K
A
D
T
E
F
-
F
Q
E
F
A
SG
T
C
P
I
P
W
Q
E
-
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
62.51
26%
-116
- C1 -
-
5ACB
1
CDK12_HUMAN
C:
[124-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
S
F
M
K
---
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
---
N
N
S
G
-------------
Q
I
K
L
A
D
F
G
--
L
---
A
R
-------
L
Y
-----------
N
S
E
E
S
------
R
P
Y
T
N
K
V
I
T
L
W
Y
---
R
P
P
E
L
L
L
G
E
E
R
Y
-----
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
---------------------------------------------
I
F
Q
A
N
L
E
L
A
Q
L
--
E
L
I
S
R
L
C
G
S
P
---
C
-
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
Y
R
R
R
L
R
E
E
F
S
--
F
I
P
S
A
-
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
-----
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
61.85
26%
-122
- C1 -
-
4CXA
1
CDK12_HUMAN
A:
[124-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
S
F
M
K
---
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
---
N
N
S
G
-------------
Q
I
K
L
A
D
F
G
--
L
---
A
R
-------
L
Y
-----------
N
S
E
E
-------
R
P
Y
T
N
K
V
I
T
L
W
Y
---
R
P
P
E
L
L
L
G
E
E
R
Y
-----
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
---------------------------------------------
I
F
Q
A
N
L
E
L
A
Q
L
--
E
L
I
S
R
L
C
G
S
P
---
C
-
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
Y
R
R
R
L
R
E
E
F
S
--
F
I
P
S
A
-
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
-----
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
58.52
26%
-119
- C1 -
-
4UN0
-
CDK12_HUMAN
C:
[836-1029]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
S
F
M
K
---
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
---
N
N
S
G
-------------
Q
I
K
L
A
D
F
G
--
L
---
A
R
-------
L
Y
-----------
N
S
E
E
S
------
R
P
Y
T
N
K
V
I
T
L
W
Y
---
R
P
P
E
L
L
L
G
E
E
R
Y
-----
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
---------------------------------------------
I
F
Q
A
N
L
E
L
A
Q
L
--
E
L
I
S
R
L
C
G
S
P
---
C
-
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
--
Q
Y
R
R
R
L
R
E
E
F
S
--
F
I
P
S
A
-
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
-----
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
56.35
29%
-51
- C1 -
-
2PK9
1
PHO85_YEAST
A:
[109-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
V
K
Y
F
Q
W
---
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
K
R
G
-------------
Q
L
K
L
G
D
F
G
--
L
---
A
R
-------
A
F
--------------
G
I
P
V
-
N
T
F
S
S
E
V
V
T
L
W
Y
R
A
------
P
D
V
L
M
G
S
-----
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
--------
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
--
F
D
I
M
G
-
T
P
N
E
S
--
L
W
P
S
V
T
--
K
L
P
K
Y
N
P
N
I
Q
Q
--
R
P
P
R
D
L
-------------
R
Q
V
L
-----------
Q
P
H
---------
T
K
E
P
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
-----
S
A
K
Q
A
L
H
H
P
W
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
56.21
19%
21
- C1 -
-
4XHG
2
?
A:
[2-397]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
R
V
G
R
K
F
R
I
G
R
KI
G
S
G
S
F
G
-
D
I
Y
H
G
T
N
L
-
I
S
G
E
E
V
-----
A
I
R
L
E
S
-----
I
R
S
R
H
P
Q
L
D
Y
E
S
R
V
Y
K
Y
L
-----------
S
G
G
V
G
I
P
F
I
R
W
F
G
R
E
G
E
Y
N
A
M
V
I
D
L
L
G
P
S
-
L
E
D
L
F
----
N
Y
C
H
R
K
F
S
F
K
T
V
I
M
L
A
L
Q
M
I
C
R
V
Q
Y
I
H
G
R
S
F
I
H
R
D
I
K
P
D
N
F
L
M
G
V
G
R
R
G
S
-------------
T
V
H
V
I
D
F
G
--
L
---
S
K
-------
K
Y
-----------
R
D
F
N
T
H
R
-
H
I
-
P
Y
R
E
N
K
S
L
-------
T
G
T
A
R
Y
A
S
V
N
T
H
L
G
I
E
Q
S
R
R
D
D
L
E
S
L
G
Y
M
L
I
Y
F
C
K
-
G
-----
S
L
P
W
Q
G
L
K
A
T
T
K
K
Q
K
Y
D
R
I
L
E
K
K
L
C
I
S
V
E
T
L
C
AG
L
P
L
E
F
S
--
E
Y
M
N
Y
C
R
N
L
K
F
--
D
E
R
P
D
--------------
Y
L
Y
L
A
R
L
F
K
D
L
S
I
K
L
E
Y
H
N
D
H
L
F
D
W
T
M
L
R
Y
T
K
A
M
-
V
E
------
K
K
N
D
S
F
N
K
V
-----
K
L
L
A
M
K
K
F
A
S
H
F
H
Y
C
K
N
D
D
K
H
Y
P
T
P
E
E
I
K
Q
--
Q
-
T
V
Q
N
N
N
A
A
P
E
L
L
S
A
I
D
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
55.75
29%
-49
- C1 -
-
4KRC
1
PHO85_YEAST
A:
[109-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
V
K
Y
F
Q
W
---
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
K
R
G
-------------
Q
L
K
L
G
D
F
G
--
L
---
A
R
-------
A
F
--------------
G
I
P
V
-
N
T
F
S
S
E
V
V
T
L
W
Y
R
A
------
P
D
V
L
M
G
S
-----
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
--------
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
--
F
D
I
M
G
-
T
P
N
E
S
--
L
W
P
S
V
T
--
K
L
P
K
Y
N
P
N
I
Q
Q
--
R
P
P
R
D
L
-------------
R
Q
V
L
-----------
Q
P
H
---------
T
K
E
P
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
-----
S
A
K
Q
A
L
H
H
P
W
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
54.30
29%
-49
- C1 -
-
2PMI
2
PHO85_YEAST
A:
[109-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
V
K
Y
F
Q
W
---
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
K
R
G
-------------
Q
L
K
L
G
D
F
G
--
L
---
A
R
-------
A
F
--------------
G
I
P
V
-
N
T
F
S
S
E
V
V
T
L
W
Y
R
A
------
P
D
V
L
M
G
S
-----
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
--------
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
--
F
D
I
M
G
-
T
P
N
E
S
--
L
W
P
S
V
T
--
K
L
P
K
Y
N
P
N
I
Q
Q
--
R
P
P
R
D
L
-------------
R
Q
V
L
-----------
Q
P
H
---------
T
K
E
P
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
-----
S
A
K
Q
A
L
H
H
P
W
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
53.50
18%
5
* C1 *
-
4YZC
1
ERN1_HUMAN
A:
[74-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
F
Q
Y
I
A
--
I
E
L
C
A
-
A
T
L
Q
E
Y
V
E
Q
-----------------
E
-
P
I
T
L
L
Q
---
Q
T
T
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
I
---
S
M
P
N
AHG
K
I
--------
K
A
M
I
S
D
F
G
-
L
C
---
K
K
-------
L
A
VRHSFSRRS--
G
V
P
G
T
E
G
-
W
I
-
A
P
E
M
L
S
--
C
-------------------
K
E
N
P
T
Y
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
I
S
-
E
G
S
H
P
-------
F
G
K
S
L
Q
---------------------------
R
--
Q
---
A
N
I
L
L
G
A
--
C
---
S
L
---
D
C
-
L
H
-------------
P
------------------
E
K
H
E
D
V
I
-
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
-----
S
A
K
H
V
L
K
H
P
F
F
W
S
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
--
E
-
S
L
D
G
---
P
I
V
K
Q
L
E
R
G
G
R
A
V
V
K
M
D
W
R
E
N
I
T
V
----
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
---------
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
53.43
24%
-59
- C1 -
-
5G6V
3
CDK16_HUMAN
A:
[102-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
L
F
L
F
---
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
E
R
G
-------------
E
L
K
L
A
D
F
G
-
L
A
RAK---------
T
Y
-----------
D
N
-----------
E
V
V
T
L
W
Y
------
R
P
P
D
I
L
L
G
S
T
-----
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
-------
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
---
G
T
P
T
E
E
T
--
W
P
G
I
L
S
N
E
E
F
K
T
Y
N
--------------------
Y
-
P
K
Y
R
A
E
A
L
L
S
H
A
P
R
L
------
D
S
D
G
A
D
---------------
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
-----
S
A
E
D
A
M
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
51.87
18%
-
- C1 -
-
3H4J
-
SNF1_SCHPO
B:
[27-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
H
I
---
G
P
Y
I
I
R
E
T
L
G
E
G
S
F
G
K
V
K
L
A
T
H
YKTQQ
K
V
A
L
K
F
I
S
R
Q
L
L
K
K
S
D
M
H
M
R
V
E
R
E
I
S
Y
L
K
LLRHPHIIKLY
D
V
I
T
T
P
T
D
I
V
M
--
V
I
E
Y
A
G
G
E
L
F
D
Y
I
V
E
K
-
K
R
--
M
-------
T
E
D
E
-
G
R
R
F
F
Q
---
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
D
D
N
L
-------------
N
V
K
I
A
D
F
G
L
S
N
---
I
M
-------
T
D
-----------
G
N
F
L
K
T
S
-
C
G
-
S
P
N
Y
-----------
A
A
P
E
V
I
N
G
K
-----
L
Y
A
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
V
-
G
---
R
L
P
F
D
D
E
F
I
P
N
L
F
K
K
V
N
S
C
V
Y
V
M
P
D
F
L
S
P
G
A
Q
S
L
--
I
R
R
M
I
V
--
A
D
P
M
Q
R
I
T
I
Q
E
IR
R
D
P
W
F
N
V
N
L
P
D
Y
L
R
-
P
M
E
E
V
Q
G
S
Y
A
D
S
R
I
V
S
K
L
G
E
A
M
G
F
S
E
D
Y
I
V
E
A
L
R
S
D
E
---
N
N
E
V
K
E
A
Y
N
L
L
H
E
N
Q
V
-----
I
Q
E
K
L
E
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
51.47
15%
-25
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
E
Q
S
L
K
N
L
V
V
S
E
K
---
I
L
G
Y
-----
G
S
S
G
T
V
V
F
Q
G
S
F
Q
-----
G
R
P
V
A
V
K
R
M
L
I
D
F
C
D
I
A
L
M
E
I
K
L
L
T
E
S
D
D
-----------
H
P
N
V
I
R
Y
Y
C
S
E
--
T
T
D
R
F
L
Y
I
A
L
E
L
C
N
L
N
-
L
Q
--
D
----
L
V
E
S
K
Y
N
-
P
I
S
L
L
R
---
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
---
S
T
S
------------------
S
R
F
T
-
A
D
---
Q
Q
-------
T
G
-----------
A
E
N
L
R
I
L
-
I
S
-
D
F
G
L
C
K
K
L
D
S
T
S
GWR
A
P
E
L
L
E
E
S
N
N
L
Q
T
K
R
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
-
K
--
G
K
H
P
F
G
D
K
Y
S
R
E
S
N
I
I
R
G
I
F
S
L
D
E
M
K
C
L
H
D
R
S
L
I
A
--
E
A
T
D
L
I
--
S
Q
M
I
D
H
D
P
L
K
R
--
P
T
A
M
K
V
L
R
H
P
L
F
W
P
-
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
-------------
E
N
R
D
P
P
S
----------
A
L
L
M
K
F
D
A
G
-----
S
D
F
V
I
P
S
G
D
W
T
V
K
F
D
K
T
F
M
D
R
K
Y
H
S
S
K
L
M
D
L
L
R
-
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
-
Y
D
Y
----
F
T
K
R
F
P
N
L
-
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
51.37
25%
-28
- C1 -
-
4AU8
2
CDK5_HUMAN
A:
[104-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
I
-
V
K
S
F
L
F
---
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
R
N
G
-------------
E
L
K
L
A
D
F
G
--
L
---
A
R
-------
A
F
--------------
G
I
P
V
R---
S
A
E
V
V
T
L
W
Y
------
R
P
P
D
V
L
F
G
A
K
L
Y
-----
S
T
S
I
D
M
W
S
A
G
C
I
----------------------------------
F
A
E
L
A
N
A
G
R
P
L
--
F
P
G
N
D
V
--
D
D
Q
L
K
R
I
F
R
L
L
--
G
T
P
T
E
-
E
Q
W
P
S
M
T
K
L
P
D
------
Y
K
P
Y
P
M
Y
-----
P
A
T
T
S
L
V
N
V
V
P
K
L
N
A
T
G
---
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
-----
S
A
E
E
A
L
Q
H
P
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
50.93
29%
-
- C1 -
-
4KRD
-
PHO85_YEAST
A:
[109-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
V
K
Y
F
Q
W
---
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
K
R
G
-------------
Q
L
K
L
G
D
F
G
--
L
---
A
R
-------
A
F
--------------
G
I
P
V
-
N
T
F
S
S
E
V
V
T
L
W
Y
R
A
------
P
D
V
L
M
G
S
-----
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
--------
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
--
F
D
I
M
G
-
T
P
N
E
S
--
L
W
P
S
V
T
--
K
L
P
K
Y
N
P
N
I
Q
Q
--
R
P
P
R
D
L
-------------
R
Q
V
L
-----------
Q
P
H
---------
T
K
E
P
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
-----
S
A
K
Q
A
L
H
H
P
W
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
50.21
21%
17
- C1 -
-
3SDJ
1
IRE1_YEAST
K:
[100-419]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
Y
I
A
--
L
E
L
C
-
N
L
N
L
Q
D
L
V
E
S
K
-
N
V
--
S
DENL
K
L
Q
K
E
Y
N
-
P
I
S
L
L
R
---
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
---
S
T
S
S
RFTADQQTGAENL
R
I
L
I
S
D
F
G
-
L
C
---
K
K
-------
L
D
SGQSSFRTNLN
N
P
S
G
T
S
G
-
W
R
-
A
P
E
L
L
E
E
S
T
-------------------
K
R
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
--------
F
G
D
K
Y
S
R
-----------------------------
E
S
N
I
I
R
G
I
F
S
--------
L
D
E
M
K
C
-----------------------------
L
---
H
D
R
S
-
L
I
A
E
-
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
-----
T
A
M
K
V
L
R
H
P
L
F
W
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
--
E
N
R
D
P
P
S
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
D
W
T
V
K
-
F
D
K
----
T
F
M
D
N
L
E
R
Y
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
N
F
M
---------
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
49.48
21%
2
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[81-405]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
F
L
Y
I
A
--
L
E
L
C
-
N
L
N
L
Q
D
L
V
E
S
K
---------------
Y
N
-
P
I
S
L
L
R
---
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
---
S
T
S
S
RFTADQQTGAEN
L
R
I
L
I
S
D
F
G
-
L
C
---
K
K
-------
L
D
S--------------
T
S
G
-
W
R
-
A
P
E
L
L
E
E
S
N
N
----------
L
-----
Q
T
K
R
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
--------
F
G
D
K
Y
S
R
-----------------------------
E
S
N
I
I
R
G
I
F
S
-----------
L
D
E
M
---------------
K
------
C
--------
L
H
D
R
S
-
L
I
A
E
-
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
-----
T
A
M
K
V
L
R
H
P
L
F
W
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
--
E
N
R
D
P
P
S
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
D
W
T
V
K
-
F
D
K
----
T
F
M
D
-----
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
---------
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
48.61
24%
-58
- C1 -
-
3MTL
-
CDK16_HUMAN
A:
[102-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
L
F
L
F
---
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
E
R
G
-------------
E
L
K
L
A
D
F
G
-
L
A
RAK--------------------------------------
T
L
W
Y
------
R
P
P
D
I
L
L
G
S
T
-----
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
-------
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
---
G
T
P
T
E
E
T
--
W
P
G
I
L
S
N
E
E
F
K
T
Y
N
--------------------
Y
-
P
K
Y
R
A
E
A
L
L
S
H
A
P
R
L
------
D
S
D
G
A
D
---------------
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
-----
S
A
E
D
A
M
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
47.91
18%
-23
- C1 -
-
4YZ9
1
ERN1_HUMAN
B:
[74-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
F
Q
Y
I
A
--
I
E
L
C
A
-
A
T
L
Q
E
Y
V
E
Q
K
-
D
--------
F
A
H
L
G
L
E
-
P
I
T
L
L
Q
---
Q
T
T
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
I
---
S
M
P
N
AHG
K
I
--------
K
A
M
I
S
D
F
G
-
L
C
------------------------------
E
G
-
W
I
-
A
P
E
M
L
S
------------------------
N
P
T
Y
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
I
S
-
E
G
S
H
P
-------
F
G
K
S
L
Q
---------------------------
R
--
Q
---
A
N
I
L
L
G
A
--
C
---
S
L
---
D
C
-
L
H
-------------
P
------------------
E
K
H
E
D
V
I
-
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
-----
S
A
K
H
V
L
K
H
P
F
F
W
S
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
--
E
-
S
L
D
---
G
P
I
V
K
Q
L
E
R
G
G
R
A
V
V
K
M
D
W
R
E
N
I
T
V
----
P
L
Q
T
D
L
--F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
---------
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
45.92
21%
-100
- C1 -
-
2VD5
-
DMPK_HUMAN
A:
[134-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
L
Y
L
V
--
M
E
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
-
G
--------
E
R
I
P
A
E
M
-
A
R
F
Y
L
A
---
E
I
V
M
A
I
D
S
V
H
R
L
G
Y
V
H
R
D
I
K
P
D
N
I
L
L
---
D
R
C
G
-------------
H
I
R
L
A
D
F
G
-
S
C
---
L
K
-------
L
R
ADG
T
V
R
S
L---
V
A
V
G
T
P
D
-
Y
L
-
S
P
E
I
L
Q
A
V
G
G
G
---------------
P
G
T
G
S
Y
G
P
E
C
D
W
W
A
L
G
V
F
A
Y
E
M
F
Y
-
G
Q
T
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
45.45
22%
-127
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[158-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
D
I
V
L
V
--
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
-
S
--------
Y
N
L
T
E
L
D
-
T
I
L
F
M
K
---
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN-
R
D
A
K
-------------
Q
I
K
I
I
D
F
G
-
L
A
---
R
R
-------
Y
K
PR
E
K
L
K
-----
V
N
F
G
T
P
E
-
F
L
-
A
P
E
V
V
N
Y
----------------------
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
-
G
L
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------