@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_04_0420: (2018-03-07 )
MNSPSYTPYILHTHGRSGDGTAAAAAPAMNMQTTAAAATNVGSSSSSMVGGAGSSSSVGPSSGSCVPTVHGVGYFNTFVKAIHPSDMKQALLPPNMRDRAVVLDMTHSNQVAEATAAHRRPFSSGANSRRNSSFCGNHGHVHHHPSVSRAQAVSQRSYASGSNGGLRSSSSMSGFHTAAGIYNGKNSNHHHAAATHGVNDCALPYPESASAAPHPQPHQQQQPGHPPSPAWRGHLSSMPTVNLGTSPRLLPSAVPAAASDQEDQHRRHYRARSYTVGGRVSSSRSGGGAMVAATAADATTPSASGSVGYVDSATSPSPNRSVSLASSSPAAAAPVFGAVATTAAGQCSRTPTLIRHPSVSRAGSSVETTMTAITATLPPAPPLPAYAESRASSAVTGTMTPRTPRPANAAIEAAAAGVSSARRGTRLIEHPSHGAFSGHQRSVSSDIVNGLDDSVDSVRCGSLPSASNTSAANMMGSASGTSDCYNYGSATAASRHGGTAVFAASHRYARDSVASEDKADDEGRRHRGPLRRYSTTLTNTTTEDEDEPQQQLAQPSTLELLRGNHLRRESGACAGGGNVNVAVVLSRARAARTSATGAAVAGSTNRDGSPTTAIERWRAQEQQRKRDEERQQQQQRQRLSARQWREAFHRLQEKRVQWRMRGYIGRGTSGVVYEGVLEDRKQTPVAVKVLEVGVPIPVDLDTSGDDGDGQSSRQARYTENSGTPTSAAAAAAADAAYMSPSQQEALLVLLREVEMMEKLHHENIVTCLRCQVTPVQDRYLELHQQQQQQCRDGGSTNGKGLSGAAAAGRDSERVGERRYDSAGRHYVDNGKAAVCDGAFSASQSPQRNAAARIPVQVEIVMELCNRGTISSVVRRSPGGQLPVRVARRYLRDVLKGLAYLHRNNFIHRDVKGDNVLISADDVAKLADFGCSRRIVLTNNVHGTADSEGTTSSIATTRTAATDSRFTTMAEYQWFDTTGVAQTMVGTPMFMAPEIIQASGPPCMATPTASSLASSSGEGNDGGHGSSRKATSPPAPVGYTASADIWSFGCLVLEVFGRTPWPTSGSNAYHLMKQIEQSVADLPPGVPDGTPAELLGLLRCCFHRDPHRRSTARALLRAPWMTCKDEELEEMPPRRRY
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.....--..670.......680.......690.......700.......710.......720.......730.......740.......750.......-760.......770.......780-........790.......800.......810.......820.......830.......840.......850.......860.......870......--.880.......890.......900.......910.....--.---.--920-.----.-.......930.......940.......950.......960......---.970...--....980.......990.......1000......1010......1020......1030......1040......1050..-....1060...-...1070...-...--1080......1090......1100....---.-----.1110......1120--......-------1130...--------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNSPSYT
P
Y
I
L
H
THGRSGDGTAAAAAPAMN
M
Q
T
T
A
A
A
A
TNVGSSSSSMVGGAGSSSSVGPSSGSCV
P
T
VHG
V
G
Y
F
N
T
F
V
K
AI
H
P
S
D
M
K
Q
ALLPPNMRD
R
A
V
V
L
D
MTHSN
Q
V
A
E
A
T
A
AHRRPFSSGANSRRNSSFCGNHGHVHHHPS
V
S
R
A
Q
A
V
S
QRSYASGSNGGLRSSSSMSG
F
H
T
A
A
G
IYNGKNSNH
H
H
AAATHGVNDCALPYPESASAAPHPQPHQQQQPGHPPS
P
A
W
RGHLSSMPTVNLGTSPRLLPSAVPAAASD
Q
E
D
Q
H
R
R
H
Y
RAR
S
Y
T
VG
G
R
VSSSRSGG
G
A
M
V
A
A
TAADATTPSASGSV
G
Y
VDSATSPSPN
R
S
V
S
LASSSPAAAA
P
V
F
G
A
V
A
TTAAGQCSRT
P
T
L
IRHPSVSRAGSSV
E
T
T
M
T
A
I
T
ATLPPAPPL
P
A
Y
A
E
SRASSAVTGTMTPRTPRPA
N
A
A
I
E
A
A
A
A
G
V
S
S
ARRG
T
R
LIEHPSHGAFSGHQR
S
V
S
S
D
I
V
NGLDDSVDSVRCGSLPSASNT
S
A
A
N
MMGSASGT
S
D
C
YNYGSATAASRHG
G
T
A
V
F
AASHRYARDSVASEDKADDEGRRHRGP
L
R
R
Y
S
T
TLTNTTTEDED
E
P
Q
Q
Q
LAQ
P
S
T
L
E
L
L
RGNHLRRESGACAGGGN
V
N
V
A
V
V
LSRARAARTSAT
G
A
A
V
AGSTNRDGSP
T
T
A
I
E
R
W
R
A
Q
E
Q
Q
R
K
R
D
E
E
R
Q
Q
Q
Q
Q
R
Q
R
L
S
A
R
Q
W
R
E
A
F
H
R
L
Q
E
K
R
V
Q
W
R
M
RGYIGRG--TSG
V
V
Y
E
G
V
L
EDRKQT
P
V
A
V
K
V
L
EVGVP
I
P
V
DLDTSGDDGDGQSSR
Q
A
RYTENSGTPT
S
A
A
A
A
AAADAAYMSP
S
Q
Q
E
A
L
L
V
L
L
R
E
V
E
M
M
E
K
L
-
H
H
E
N
I
V
T
C
L
R
CQVTP
V
Q
D
R
Y
L
E
--
L
H
Q
Q
Q
Q
Q
Q
C
RDGGSTNGKGLSGAAAAGR
D
S
E
R
V
G
E
RRYDSAGRHYVDNG
K
A
A
VCDGAFSASQSPQRNAAARI
P
V
Q
V
E
I
V
M
E
L
CNRG
T
I
S
S
V
V
RRSPG--GQ
L
P
V
R
V
A
R
R
Y
L
R
D
V
L
K
G
L
A
Y
L
H
RNN
F
I
HRDVKGD
N
V
L
I
--
S
---
A
--
D
---
D
----
V
-
A
K
L
A
DFGCS
R
R
I
V
L
TNNVHGTADSEGTTSS
I
A
T
T
RTAATDSR
F
T
T
M
---
A
E
Y
Q
W
FD--TTG
V
A
Q
T
MVGTPMFM
A
P
E
I
I
QASGPPCMATP
T
A
S
S
LASSSGEGNDGGHGSSRKATSPPAPVGYTAS
A
D
I
W
S
F
G
C
L
V
L
E
V
F-GRTPWPTSGS
N
-
A
Y
H
L
M
K
Q
I
E
Q
-
S
V
A--DLPPGVPDG
T
P
A
E
L
L
G
L
L
R
C
C
FHRDPHR---
R
-----
S
T
A
R
A
L
L
RAPWMTCK--
D
E
E
L
E
E-------MPPRRRY--------------------------------------------
39
HHSearch
83.42
29%
-100
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-352]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
--
S
T
G
I
V
C
I
A
T
V
R
S
-
S
G
K
L
V
A
V
K
K
M
D
L
R
K
------------------------------------------------
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
----------------------------------------------------------------------------------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
--
T
---
H
--
D
---
G
----
R
-
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
--------------------------------------------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
--------------------------------------
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
---
L
K
A
M
K
M
I
R
D
-
N
L
P
--
P
R
-
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
---
R
-----
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
--
G
P
--------------------------------------------------------------
43
HHSearch
78.29
27%
-89
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
--
T
Y
G
D
V
Y
K
A
R
N
V
N
-
T
G
E
L
A
A
I
K
V
I
K
L
E
P
------------------------------------------------
G
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
----------------------------------------------------------------------------------
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
----
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
--
T
---
D
--
N
---
G
----
H
-
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
--------------------------------------------
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
R
-----------------------------------
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
---
R
A
L
F
L
M
T
K
S
N
F
Q
--
P
P
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
---
R
-----
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
-------------------------------------------------------------------
38
HHSearch
75.68
28%
-72
- C1 -
-
2W4O
1
KCC4_HUMAN
A:
[51-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
D
F
F
E
V
E
S
E
L
G
R
G
--
A
T
S
I
V
Y
R
C
K
Q
K
G
-
T
Q
K
P
Y
A
L
K
V
L
K
K
------------------------------------------------------------
I
G
V
L
L
R
L
-
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
----------------------------------------------------------------------------------
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
----
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
A
TPA
P
--
D
---
A
----
P
-
L
K
I
A
D
F
-------------------------------------------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
--------------------------------------
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
-
Q
-
F
M
F
R
R
I
L
N
-
C
E
Y
--
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
---
R
-----
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
--
A
A
N
F
V
H
-------
M
D
T
------------------------------------------------
25
HHSearch
75.28
27%
-59
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
--
P
F
S
V
V
R
R
C
I
N
R
E
-
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
-------------------------------------------
S
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
----------------------------------------------------------------------------------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
---
S
--
K
ENS
A
----
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--------------------------------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
--------------------------------------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
----
L
F
E
G
I
I
K
-
G
K
Y
--
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
-----
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
--
D
---------------------------------------------------------------
26
HHSearch
75.27
27%
-60
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
--
P
F
S
V
V
R
R
C
I
N
R
E
-
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
-------------------------------------------
S
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
----------------------------------------------------------------------------------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
---
S
--
K
ENS
A
----
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--------------------------------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
--------------------------------------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
----
L
F
E
G
I
I
K
-
G
K
Y
--
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
-----
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
--
D
---------------------------------------------------------------
23
HHSearch
75.07
20%
-81
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[21-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
Y
M
I
A
E
D
L
G
R
G
--
E
F
G
I
V
H
R
C
V
E
T
S
-
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
-------------------------------------------------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
----------------------------------------------------------------------------------
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
---
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
---
T
RR
S
---
S
----
T
-
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
---------------------------------------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
--------------------------------------
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
---
Q
Q
I
I
E
N
I
M
N
-
A
E
Y
--
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
---
R
-----
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
--
I
E
R
V
------------------------------------------------------------
37
HHSearch
74.17
23%
-67
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[10-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
------------------------------------------
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
----------------------------------------------------------------------------------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
---
D
--
R
---
N
VP
K
P
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
---------------------------------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--------------------------------------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
---
Q
E
T
L
A
N
V
S
A
-
V
N
Y
--
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
---
R
-----
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
------------------------------------------------------------------
50
Fugue
74.07
15%
-55
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
--
E
V
T
-------
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
----------
D
S
I
-
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
K
N
T
F
R
--
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
----
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
--
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
--
D
---
D
--
H
---
G
----
H
-
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
I
K
G
---------------------------------------------
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
--------------------------------------
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
-
I
K
--
R
E
E
V
E
R
-
L
V
K
--
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
---
R
LGCRG
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
--
N
F
K
R
L
G
A
GMLEPP
F
K
P
D
P
Q
A
IYCE
P
T
D
Q
D
F
Y
Q
K
F
ATGSVP
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
VFGLDGS
30
HHSearch
72.73
23%
-66
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[8-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
------------------------------------------
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
----------------------------------------------------------------------------------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
---
D
--
R
---
N
VP
K
P
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
---------------------------------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--------------------------------------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
---
Q
E
T
L
A
N
V
S
A
-
V
N
Y
--
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
---
R
-----
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
--
D
---------------------------------------------------------------
22
HHSearch
72.30
24%
-35
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[89-364]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
--
V
S
S
V
V
R
R
C
V
H
R
A
-
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
----------------------------------------
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
----------------------------------------------------------------------------------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
---
D
--
N
---
M
----
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
---------------------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
--------------------------------
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
---
I
L
M
L
R
M
I
M
E
-
G
Q
Y
--
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
-----
L
T
A
E
Q
A
L
Q
H
P
F
F
E
--------------------------------------------------------------------
40
HHSearch
70.99
22%
-62
- C1 -
-
4PF4
6
DAPK1_HUMAN
A:
[8-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
------------------------------------------
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
----------------------------------------------------------------------------------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
---
D
--
R
---
N
VP
K
P
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
---------------------------------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--------------------------------------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
---
Q
E
T
L
A
N
V
S
A
-
V
N
Y
--
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
---
R
-----
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------
29
HHSearch
70.63
28%
-39
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[6-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
D
G
Y
V
V
K
E
T
I
G
V
G
--
S
Y
S
E
C
K
R
C
V
H
K
A
-
T
N
M
E
Y
A
V
K
V
I
D
K
S
K
----------------------------------------------------
R
D
P
S
E
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
----------------------------------------------------------------------------------
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
Q
----
K
F
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
--
V
---
D
--
E
---
S
GNPE
C
-
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
--------------------------------------------
L
L
M
T
P
C
Y
---
F
V
A
P
E
V
L
K
R
Q
--------------------------------------
G
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A
N
G
P
S
D
T
P
E
E
I
L
T
R
I
G
S
-
G
K
F
--
T
L
S
G
G
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
---
R
-----
L
T
A
K
Q
V
L
Q
H
P
W
V
T
Q
K
--
D
---------------------------------------------------------------
42
HHSearch
68.84
18%
-80
- C1 -
-
1KOB
1
?
A:
[51-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
D
I
L
E
E
L
G
S
G
--
A
F
G
V
V
H
R
C
V
E
K
A
-
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
------------------------------------------------
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
----------------------------------------------------------------------------------
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
---
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
--
E
---
T
--
K
KA-
S
----
S
-
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
---------------------------------------------
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
R
E
--------------------------------------
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
---
L
E
T
L
Q
N
V
K
R
-
C
D
W
--
E
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
---
R
-----
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
--
H
S
N
L
T
-----------------------------------------------------------
24
HHSearch
68.25
25%
-33
* C1 *
-
2Y7J
1
PHKG2_HUMAN
C:
[90-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
--
V
S
S
V
V
R
R
C
V
H
R
A
-
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
----------------------------------------
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
----------------------------------------------------------------------------------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
---
D
--
N
---
M
----
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
---------------------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
--------------------------------
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
---
I
L
M
L
R
M
I
M
E
-
G
Q
Y
--
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
-----
L
T
A
E
Q
A
L
Q
H
P
F
F
E
--------------------------------------------------------------------
21
HHSearch
65.67
19%
-83
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-358]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
S
K
T
E
I
L
G
-------
Q
V
H
K
C
E
E
T
A
-
T
G
L
K
L
A
A
K
I
I
K
T
R
G
------------------------------------------------
M
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
----------------------------------------------------------------------------------
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
---
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
---
D
--
A
---
K
----
Q
-
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
---------------------------------------------
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
--------------------------------------
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
---
A
E
T
L
N
N
I
L
A
-
C
R
W
--
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
---
R
-----
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
S
R
L
S
A
-------
Q
--------------------------------------------------
36
HHSearch
63.52
24%
-80
- C1 -
-
4LQQ
1
CBK1_YEAST
A:
[97-453]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
--
A
F
G
E
V
R
L
V
Q
K
K
D
-
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
---------------------------------------------
K
K
---------------
S
-
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
----------------------------------------------------------------------------------
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
----
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
--
D
---
I
--
R
---
G
----
H
-
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
Y
-----------------------
L
T
M
S
N
R
Q
Q
I
Q
T
W
R
KS
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
Q
--------------------------------------
G
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
---
Q
E
T
Y
R
K
I
M
N
-
F
E
Q
--
T
L
Q
F
P
D
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
Q
R
LGR
H
-----
G
G
A
D
E
I
K
S
H
P
F
F
R
G
V
--
D
---------------------------------------------------------------
28
HHSearch
63.48
23%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[3-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
--
A
F
S
V
V
R
R
C
M
K
I
P
-
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
----------------------------------------------
S
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
----------------------------------------------------------------------------------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
---
S
--
K
SKG
A
----
A
-
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
--------------------------------------------
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
--------------------------------------
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
---
H
R
L
Y
Q
Q
I
K
A
-
G
A
Y
--
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
---
R
-----
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
------------------------------------------------------------------
27
HHSearch
62.79
22%
-81
- C1 -
-
4LQS
1
CBK1_YEAST
A:
[97-453]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
--
A
F
G
E
V
R
L
V
Q
K
K
D
-
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
---------------------------------------------
K
K
---------------
S
-
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
----------------------------------------------------------------------------------
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
----
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
--
D
---
I
--
R
---
G
----
H
-
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
Y
------------------------
N
R
---
Q
Q
I
Q
T
W
R
KS
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
Q
--------------------------------------
G
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
---
Q
E
T
Y
R
K
I
M
N
-
F
E
Q
--
T
L
Q
F
P
D
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
Q
R
LGR
H
-----
G
G
A
D
E
I
K
S
H
P
F
F
R
G
V
--
D
---------------------------------------------------------------
31
HHSearch
60.91
20%
-25
- C1 -
-
2WTK
1
STRAA_HUMAN
B:
[6-337]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
G
G
C
Y
E
L
L
T
V
I
G
K
G
FE
D
L
M
T
V
N
L
A
R
Y
K
P
-
T
G
E
Y
V
T
V
R
R
I
N
L
E
A
C
----------------------------------------------
S
N
E
M
V
T
F
L
Q
G
E
L
H
V
S
K
L
F
-
N
H
P
N
I
V
P
Y
R
A
T
F
I
A
D
----------------------------------------------------------------------------------
N
E
L
W
V
V
T
S
F
M
A
Y
G
S
A
K
D
L
I
C
T
H
F
M
--
D
G
M
N
E
L
A
I
A
Y
I
L
Q
G
V
L
K
A
L
D
Y
I
H
H
M
G
Y
V
H
R
S
V
K
A
S
H
I
L
I
--
S
---
V
--
D
---
G
----
K
-
V
Y
L
S
G
L
R
S
N
L
S
M
I
S
H
G
Q
R
Q
----------------------
R
V
---------------
V
H
D
F
P
K
Y
S
V
K
V
L
P
W
L
S
P
E
V
L
Q
Q
N
L
------------------------------------
Q
G
Y
D
A
K
S
D
I
Y
S
V
G
I
T
A
C
E
L
A
N
G
H
V
P
F
-
D
M
P
A
T
--
Q
M
L
L
E
K
L
----
V
P
CL---------
F
S
P
H
F
H
H
F
V
E
Q
C
L
Q
R
N
P
D
A
---
R
-----
P
S
A
S
T
L
L
N
H
S
F
F
K
Q
I
--
K
R
R
A
S
-----------------------------------------------------------
44
Fugue
60.11
22%
-10
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
-
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
A
E
E
L
M
A
C
A
G
-
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
----
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
--
S
---
S
--
D
---
G
----
S
H
A
A
L
C
D
F
G
H
A
V
C
L
----------------------------------------------------
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
--------------------------------------
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
--
T
Q
F
F
-
R
G
P
L
C
L
K
I
A
S
-
E
-
P
--
P
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
---
R
-----
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
--
Q
V
G
G
L
K
-------
S
P
W
R
G
E
Y
K
E
P
RHP--------------------------------------