@TOME V2.3
(Mar 2018)
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Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
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Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
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Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
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Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_06_0660: (2018-03-07 )
MQPPQLKPALAGTADVALPAAFAGPSMTYDGSSGKCENLDSNPRSCEGDEDAGTYSADYRVYQQRPDDTHNATRRRSSSVGQLSVEQVLTSVAPLSSPPQPMAARTRSSHLPHGNGTSADRSASVSLPPAYPDRFSTHAVGDCPAHHGTVSSSWCCDSTCATRTGEANGKVPPEGDGCSERFSPHRIGSALLSSTAETAPGYLLALIGVVTGMLLFLPWSSNPVHIALMVLSSLVGCVCGLLYWISERRWYRRWRHGFYDASGAAAASCSAGGARGWHVESAVGSAGPRYHDHDADDEVSSVGMCCCAGCVSHLIDRQHFRVVLPTAQLLLLGTFVLVSPQVMATWTAPMASTTGRGGGAILADRGAGHAARYGATLYPVEAVWKTCLLHAWIGMRFSLPLLWSLLVGLVHMAVLLAQYQHAGPGTLLTLVVWMSVPLLCFAFAMCITRPRPAVVEEQQHHQLLRGRASGGGAAGYSASYGAGVGEPLPPFVNFFIGRRRDALEATCASVPYSSPSTVTTAAPAPATQYSAHPSRRVVLPPPPVAAYSPASYAQMFSAEGIDGSYLARLKVGEFGSLVRGGSGGVGIAAARYPQANYGGLGTVVPSRYESDQRLIAPQRPVRPRYNAAARSPAPSVQQGAPLLAPKFFDSAGVPPHDDLIGLATPHDITLPSQHGRARDLSAPLYSPSSLSQAVREARYEPAHYPVNNMDEVTYPTTSAAAMLPSSGDGTHPSLPLPQTSRQLAPPSRLSIVSSSTPSTMLVSNLEPAPQPRRQLRKHVQQAAAGEVEEAGAFRDDAVDSDGAAAAIVPADSSHQETRQHRRTGSATAKGQRTWSGVAATAAAAKSMSAAAPAADDDGCANGVDVPNAPVHGRGDDGEEWDSEPPLPAGTSLEDACAPYLVLDAALVIVDVGPSLCRLLGTTVDAVLFRRLPDVLAWLDVVERETAVMLVSAVAQPLRTAAAAVRGEKRGAGAHSTREEKAKKGKDMKRRHSGAQDGMRDNHHDTNENRNAPSGAAKQLQKPSEMEVRDNVAEGAPVRRITLRGHCPYYAKASGSTREISAGRCSRRPPFALCFDVWAERLAAPAPSTAGSWRRHRSSAVGGGRPLPTPFVIILRRPLLHGLCDALPLPVALVHPRTGEVLCWNRYAARLTGCTAYDMLGTPAYGSFVYEGLPGAATTAASQGGFSSTGRHLPPPPPSPSVEFASSTHRRQQSSNTAALSAATAAGTVPDGEVASNGFAPPPVKSTSPTTAALLLSSQQTTSTAFSPLQNARLQRQHGGAGSPTFVDQASPPPHAAGLYGTFTVVASQQHRDTPLPGFFYVPCTRAAAAVAGVPLSAVGHSGELAMTTAIGGGGARPSSSSSTGGGPHQISSLQLPWSLAGRGGTVAAAAGHADRVPSQLTAASQSPLSFGVGGGGGDNKNSTSGVAVGARCPRPPPPPPLAAGLDRGTDPYDEAGVATAFETDGSKEAQGDGDEDVMAAPYCSSPVMVHGLLFRATLRPLRGVLCSEEGGVVENQLGGPLRTSASAVEGEHTGGRGAEGNPFFNQPPRAAHEEDSAAVEGKDAEEGQALAREKNMQAHGDDKSGSDDSVEALLSERQPHHRHHRLHRTAAGARMPNSECEEDSGAEDQSDMDDDDDDDTPFDEDDLPKAMAGTMNGGLTLAATLEQLFATKAMACNFGLDKEPAACPRRSAASTVTTTATAASGALLSSELLPQYSLREALQQLAASESPLLLTFSEPPLYATTCASAEALLQERRLSHHRVSSPSPDEHGYSGVLTHANNGGVAAAASGGDCTSVPESYLGTPQAPFLRRQRPQVPALWGDGSSSLQFVAAVKEAVDSYRESIEEDSSGYTDLLGLLSLSGANGGCCPSSGYAARNSSSSLTPTSFGGAPDAAVTTAITADAVRQLRLLKSLSDQLLQATAAYNRTRQSMSSTTCGLSGGCGCGGVAARVSPSSSSPSLSLGLFAAPSVPDADAAHERHLHARRHGSATTPSPHKDPPAGGPLGFSAHQSPFQPPPPPPHLAFTSEEARGAHRRLQGGGPHRRQPGEPAASASTGGSGAHTGIYRDPNSTPFSVASEDVTGVAPSAVGDSRNSALKEPPPPPHHGATRTSGSGGRRDIQDGGASPVKSRPRHAAKSSTASAPLKVSRGRHTGARHGRRGGAGAGASTPAPSPPLVPLDAAVDVAKESRSSGYMGEISGSTPSSASPCGVGGSGRTAAAAPAATSSLNASTLLVAAGSVPAMSTPRPHATGASASALDVATPQTELHSSPRPCDTVVASGEGEASGRGGGAGEDAAAAGGVTSRLTTSPRYQGSLLLSPSLAAAEMGELEASYGTESRQQRPQHRSSPNIISGAGSGRGATPVKRDASPRRRSSAVYRRESSLDVLPSAPLGSGSFRGNGGLVPTSSSASPSAGAGAGGQGTGSPSPHPARTGSGSLNANANAAAAATAAVRSTPRRPGEGAVWAVLVSRDEATIPSCCISVNLGDEFRLGRSSKCTAVVSDSFVSSTQFSIVRTVSASTTAQDSQSPGSGRSERGARRNKAFTVTLYDRSANGTYVNVKKLGKDKSCVLRDRALITFRLSTSQFFLGFVFMLTDERGVPLDDRTGMGGGSGLRSLLDARLSPQPQTGRRTNASSTGGGGKESSSSQNTVMASPNALSTSAARRNTPRALSTPDNSSFASGTPNGSRRAGGGAPRSSRHAHRETIEWKIGEEMLGKGGNAEVYLGINLTNGQLIAVKRVRLPTFAHGSDAEQDPEAKAILQQYRSLQEEISVLSKATHPNIVQYYGSSQNSTYFNILLEFVPGGSLRHLLDNFGALSPGVILSYVHQALEGLAYLHRHNIVHSDFKAANILITEKGKVKLTDFGTARLLTRPHATAARGGGEAQSVTSRTTPGQRKDDPVSVGAGGTLHIAGTLRWMDPALFHNPHSSGAADVTAAATAKDSSDKLGGPTKAGDIWSVGCTMIEMMSGEAPWFEYDFESEEQIVNLLTYTAEPPEIPECPECPDLVTIAQTCLKMDPARRPTCEELLRIVEEATARLQAQSTSPSVSPSREVSQQHPAVPGSVSGAGTGLRSSSTLLCPQMEPGTNSAFASLTANPAVAAYGPGTDDRRRAERVGRPSDSTPMSFAVGGDGGSSAQLSARDAALPTVL
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500.---------.....2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620......2630......2640......2650......2660......2670......2680......2690..----....2700......2710......2720......2730......2740......2750......2760......2770......2780......2790......2800......2810...----....2820----........2830......2840......2850-..---.----.-..2860......2870......2880......2890......2900......2910......2920-......2930......2940......2950......2960......2970......2980......-2990.....-.3000--......3010......3020.-----.....---3030......3040......------3050......3060......3070......3080......3090......3100......3110......3120......3130......3140......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQPPQLKPALAGTADVAL
P
A
AFAGPS
M
T
YDGSSGKCENLDSNPRSCEGDEDAGTYSAD
Y
R
V
Y
QQRPDDT
H
N
A
T
R
RRSSSVG
Q
L
S
V
E
Q
V
L
T
S
VAPLSSPPQ
P
M
A
A
RTRSSHLPHGNGTSADRSASVSLPPAYPDRFSTHAVGDCPAHHGTVSSSWCCDSTCATRTGEANGKVPPEGDGCSERF
S
P
H
R
I
G
S
A
L
L
S
STAETA
P
G
Y
L
L
A
L
I
G
V
V
T
G
M
L
L
F
L
PWSSN
P
V
H
I
A
L
M
V
L
S
S
L
V
G
C
V
C
G
L
L
Y
W
I
S
E
R
R
W
Y
R
R
W
RHGFYDASGAAAASCSAGGARG
W
H
V
ESAVGSAGPRYHDHDAD
D
E
V
S
S
V
G
M
C
C
C
A
G
C
V
S
H
L
I
D
R
Q
H
F
R
V
V
L
P
T
A
Q
L
L
L
L
G
T
F
V
LVSP
Q
V
M
A
T
WTAPMASTTGRGG
G
A
I
L
ADRGAGH
A
A
RYG
A
T
LY
P
V
E
A
V
W
K
T
C
L
L
H
A
W
I
G
M
R
F
S
L
P
L
L
W
S
L
L
V
G
L
V
H
M
A
V
L
L
A
Q
Y
QHAG
P
G
T
L
L
T
L
V
V
W
MS
V
P
L
L
C
F
A
F
A
M
C
ITRPRP
A
V
V
E
E
Q
Q
H
H
Q
L
L
RGRASGGGAAGYSASYGAGVGEPL
P
P
F
V
N
F
F
I
GRR
R
D
A
L
E
A
T
C
ASVPYSSPS
T
V
TTAAPAPATQYSAHPS
R
R
V
VLPPPPVAAYS
P
A
S
Y
A
Q
M
F
SAEGI
D
G
S
Y
L
A
R
L
KVGE
F
G
S
L
VRGGSGGV
G
I
A
A
ARYPQANYGGLGTVVPSRYESDQRLIAPQRPVRPRYNAAARSPAP
S
V
QQGAPLL
A
P
K
FFDSAGVPPHDDLIGLATPHDITLPSQHGRARDLSAPLY
S
P
S
S
L
S
Q
A
V
R
EARYEPAHYPVNNMDEVTYPTT
S
A
A
AMLPSSGDGTHPSLPLPQTSRQLAPPS
R
L
S
I
VSSSTP
S
T
M
L
VSNLEPAP
Q
P
R
R
Q
L
R
K
H
V
Q
Q
A
AAGE
V
E
EAGAFRDDAVDSDG
A
A
A
A
I
VPADS
S
H
Q
E
T
R
Q
H
RRTGSATAKGQRTWS
G
V
A
A
T
A
A
A
A
K
SMSAAAPAADDDGCANGVDVPNAPVHGRGDDGEEWDSEPPLPAGTS
L
E
D
ACA
P
Y
L
V
L
D
A
A
L
V
I
V
DV
G
P
S
L
C
R
L
L
G
T
T
V
D
A
V
L
F
R
R
L
P
D
V
L
A
W
L
D
V
V
ER
E
T
A
V
M
L
V
S
A
V
A
Q
P
L
R
T
A
A
A
A
VRGEKRGAGAH
S
T
R
E
E
K
A
K
K
G
K
D
M
K
R
RHSGAQDGMRDNHHDTNENRNAPS
G
A
A
K
QLQKPS
E
M
E
V
RDNVAEGA
P
V
R
R
I
T
LRGHC
P
Y
Y
AKASGSTREISAGRCSRRPP
F
A
L
C
F
D
V
W
A
E
R
LAAPAPST
A
G
S
W
R
R
H
RSSAVGGGRPLPT
P
F
V
I
I
L
R
R
P
L
L
H
G
L
C
DALPL
P
V
A
L
VHPRTG
E
V
L
C
W
N
R
Y
A
A
R
LTGCT
A
Y
DMLGTPAY
G
S
F
V
YEGLPGAATTAASQGGFSSTGRHLPPPPPSPS
V
E
F
A
S
S
T
H
R
RQQSSNT
A
A
L
SAATAAGTVPDGEVASNGFAPPPVKSTSP
T
T
A
A
L
L
LSSQQTTSTAFS
P
L
Q
N
A
R
L
Q
R
QHGGAGSPTFVDQASPPPHAAGL
Y
G
T
F
T
V
V
ASQQHRDTPLP
G
F
F
Y
VPCT
R
A
A
A
A
VAGVP
L
S
AVGHSG
E
L
A
M
T
T
A
IGGGGARPSSSSSTGGGPHQISSLQL
P
W
SLAGRGG
T
V
A
AAAGHADRV
P
S
Q
L
TAASQSP
L
S
F
GVGGGGGDNKNSTS
G
V
A
VGARCPRPPPPP
P
L
A
AGLDRGTDPYDEAG
V
A
T
A
FETDGSKEAQGDGDED
V
M
AAPYCSS
P
V
M
V
H
G
L
L
F
R
A
T
L
R
P
L
R
G
V
LCSEEGGV
V
E
NQLGGPLRTSASAVEGEHTGGRGAEGNPFFNQPPRAAHEEDSAAVEGKD
A
E
E
G
Q
A
L
A
R
EKNMQAHGDDKSGS
D
D
S
V
E
A
L
L
S
ERQP
H
H
R
H
H
R
L
H
RTAAGARMPNSECEEDSGAEDQSDMDDDDDDDTPF
D
E
D
D
L
P
K
A
M
A
GTMNGG
L
T
L
A
A
T
L
E
Q
L
F
A
T
K
A
M
ACNFGLDKEPAACPRRSAA
S
T
V
T
T
T
ATAAS
G
A
L
L
S
S
E
LL
P
Q
Y
S
L
R
E
A
L
Q
Q
L
AASES
P
L
L
L
T
FSEPP
L
Y
A
TTC
A
S
A
E
A
L
L
Q
E
R
R
LSHHRVSSPSPDEHGY
S
G
V
L
T
HANNG
G
V
A
AAASGGDCTSV
P
E
S
YLGTPQA
P
F
L
RRQRPQV
P
A
L
WGDGS
S
S
L
Q
F
V
A
A
V
K
E
A
V
D
S
Y
R
E
S
I
EEDSS
G
Y
T
D
L
L
G
L
L
SLSGANGGCCPSSGYAARNSSSSLTPTSFGGAPD
A
A
V
T
T
A
I
T
A
D
A
V
R
Q
L
R
L
L
K
S
L
S
D
Q
L
L
Q
A
T
A
A
Y
N
R
T
R
Q
SMSSTTCGLSGGCGCGG
V
A
A
RVSPSSSSPS
L
S
L
G
L
F
AAPSVPDA
D
A
A
H
E
R
H
L
H
A
RRHGSATTPSPHKDPPAGGPLGFSAHQSPFQPPPPPPH
L
A
FT
S
E
E
ARGAHRRLQGGGPHRRQPGEPAASASTGGSGAHTGIYRDPNSTPFSVASEDVTGVAPSAVGDSRNSALKEPPPPPHHGATRTSGSGGRRDIQDGGASPVKSRPRHAAKSSTASA
P
L
K
VSRGRHTGARHGRRGGAGAGASTPAPSP
P
L
VP
L
D
A
A
V
D
V
A
K
ESRSSGYMGEISGSTPSSASPCGVGGSGRTAAAAPAATSSLN
A
S
T
L
L
V
AAGSVPAMSTPRPHATGASAS
A
L
DVATP
Q
T
ELHSSPRPC
D
T
V
V
ASGEGEASGRGGGAGEDAAAAGGVTSRLTTSPRYQ
G
S
L
L
LSP
S
L
A
A
A
E
M
G
E
L
E
ASYGT
E
S
R
Q
QRPQHRSSP
N
I
I
SGAGSGRGATPVKRDASPRR
R
S
S
A
V
YRRESSLDVLPSAPLGSGSFRGNGGLVPTSSSASPSAGAGAGGQGTGSPSPHPARTGSGSLNANAN
A
A
A
A
A
T
A
A
V
RSTPRRPGEG
A
V
W
A
V
L
VSRDEATIP
S
C
C
I
S
VNLGDEFRLGRSSK
C
T
A
V
VSDS---------FVSST
Q
F
S
I
V
R
T
VSASTTAQDSQSPGSGRSERGARRN
K
A
F
T
V
T
L
Y
DRSANG
T
Y
V
N
V
K
KLGKDK
S
C
V
L
RD
R
A
L
I
T
F
R
LST
S
Q
F
F
L
G
F
V
F
M
L
TDERGVPLDDRTGMG
G
G
S
G
L
R
S
L
L
D
A
RLSPQPQTGRRTNASSTGGGGKESSSSQN
T
V
M
ASPNALSTSAARRNTPRALSTPDNSSFASGTPNGSRRAGGGAP----RSSRHAHR
E
T
I
E
W
KI
G
E
E
M
LGKGG
N
A
E
V
Y
L
G
I
N
LTN
G
Q
L
I
A
V
K
R
VRLPTFAHGSDAEQD
P
E
A
K
A
I
L
Q
Q
Y
R
S
L
Q
E
E
I
S
V
L
SKATHP
N
I
V
Q
Y
YGSSQNS
T
Y
F
N
I
L
L
EFVPG
G
S
L
R
H
L
L
-
D
N
FG----AL
S
P
G
--
V
----
I
L
S
Y
V
H
Q
A
L
E
G
L
A
Y
L
H
RHNIVHSDF
K
A
A
N
I
L
I
-TE---K----G-
K
V
K
L
TDFGT
A
R
L
LTRPHATAARGGGEAQSVTSRTTPGQRKDD
P
V
S
VGAG
G
T
L
H
I
A
G
T
L
R
WM
D
P
A
LF-HNPHSSGAA
D
V
T
A
A
ATAKDSSDKLGGPTKAGD
I
W
S
V
G
C
T
M
I
E
MMSGEAP
W
F
EYDFE
S
E
E
Q
I
V
N
L
L
T-YTAEPPEIP-ECPEC--P
D
L
V
T
I
A
Q
T
C
L
KMDPARRP
T
C
-----
E
E
L
L
R
---
I
V
E
E
A
T
A
R
LQAQSTSPSVSP------
S
R
E
V
S
Q
QHPAVPGSVSGAGTGLRSSS
T
L
LCPQMEPGTNSA
F
A
SLTANP
A
V
A
AYGPGT
D
D
R
R
R
A
E
RVGRPSDSTP
M
S
F
A
VGGDGGSSAQLSARDAALPTVL
22
HHSearch
78.30
31%
-91
- C1 -
-
4G3F
1
A:
[59-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
M
T
H
Q
-
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---------------------
F
R
V
E
E
L
V
A
C
A
G
L
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
-
K
Q
M
G
----
C
L
P
E
D
--
R
----
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
-
S
S
---
D
----
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
--------------------------------------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
-
M
G
----------------------
K
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
Y
F
R
G
P
--
L
C
L
K
I
A
S
-
E
P
P
P
I
R
E
I
--
P
P
S
C
A
--
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
-----
M
E
L
R
R
---
K
V
G
K
A
L
Q
E
V
G
G
-------------------------------------------------------------------------------------------------------------------
40
HHSearch
77.42
31%
-88
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
I
Q
-
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
----------------
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
-
H
V
T
G
----
P
L
S
E
L
--
Q
----
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
-
T
D
---
N
----
G
-
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
-------------------------------
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
-
A
V
E
-------------------
R
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
--
R
A
L
F
L
M
T
K
-
S
N
F
Q
P
P
K
L
K
D
K
M
K
W
S
--
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
-----
E
K
L
L
Q
---
H
-----------------------------------------------------------------------------------------------------------------------------
43
Fugue
77.00
29%
-6
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
TEK
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---------------------
F
R
A
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
-
K
E
Q
G
----
C
L
P
E
D
--
R
----
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
-
S
S
---
D
----
G
S
H
A
A
L
C
D
F
G
H
A
---------------------------------------
V
C
L
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
-
L
G
R
----------------------
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
F
-----
F
R
G
P
L
C
L
K
-
I
A
S
E
P
P
P
V
R
-
E
I
P
P
S
CA
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
-----
A
E
L
G
G
---
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
------
K
E
P
R
H
P
----------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.88
29%
-84
- C1 -
-
3A7G
-
STK24_HUMAN
A:
[28-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
----
P
L
D
E
T
--
Q
----
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
----
G
-
E
V
K
L
A
D
F
G
V
A
--------------------------
G
Q
L
T
D
T
Q
I
K
R
N
T
-----
F
V
G
T
P
F
W
M
A
P
E
V
I
-
K
Q
-------------
S
A
Y
D
S
K
---------
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
----
H
P
M
K
V
L
F
L
I
-
P
K
N
N
P
P
T
L
E
-
G
N
Y
S
K
--
P
-
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
-----
K
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.59
28%
-85
- C1 -
-
2XIK
2
STK25_HUMAN
A:
[9-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
Q
H
S
R
V
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
---------------
E
E
A
E
-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
K
P
-
G
----
P
L
E
E
T
--
Y
----
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
Q
----
G
-
D
V
K
L
A
D
F
G
V
A
--------------------------
G
Q
L
T
D
T
Q
I
K
R
N
T
-----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
F
K
A
------------------
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
----
N
S
D
L
H
P
M
R
V
L
F
L
I
-
P
K
N
S
P
P
T
L
--
E
G
Q
H
S
--
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
-----
K
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
75.56
30%
-85
- C1 -
-
4IDV
1
M3K14_HUMAN
A:
[80-337]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---------------------
F
R
A
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
-
K
E
Q
G
----
C
L
P
E
D
--
R
----
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
-
S
S
---
D
----
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
P
D
G
L
G
K
------------
S
--------------
L
L
T
G
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
-
L
G
----------------------
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
F
F
R
G
--
P
L
C
L
K
I
A
S
-
E
P
P
P
-
V
R
E
I
-
P
P
S
C
A
--
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
-----
A
E
L
G
G
---
K
V
N
R
A
L
Q
Q
V
G
G
L
------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
75.17
29%
-82
- C1 -
-
3A7H
1
STK24_HUMAN
A:
[28-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
----
P
L
D
E
T
--
Q
----
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
----
G
-
E
V
K
L
A
D
F
G
V
A
--------------------------
G
Q
L
T
D
T
Q
I
K
R
N
T
-----
F
V
G
T
P
F
W
M
A
P
E
V
I
-
K
Q
-------------
S
A
Y
D
S
K
---------
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
----
H
P
M
K
V
L
F
L
I
-
P
K
N
N
P
P
T
L
E
-
G
N
Y
S
K
--
P
-
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
-----
K
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.38
29%
-82
- C1 -
-
3CKX
1
STK24_HUMAN
A:
[13-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------
E
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
----
P
L
D
E
T
--
Q
----
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
----
G
-
E
V
K
L
A
D
F
G
V
A
--------------------------
G
Q
L
T
D
T
Q
I
K
R
N
T
-----
F
V
G
T
P
F
W
M
A
P
E
V
I
-
K
Q
-------------
S
A
Y
D
S
K
---------
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
----
H
P
M
K
V
L
F
L
I
-
P
K
N
N
P
P
T
L
E
-
G
N
Y
S
K
--
P
-
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
-----
K
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.22
29%
-84
- C1 -
-
4O27
1
STK24_HUMAN
B:
[12-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
----
P
L
D
E
T
--
Q
----
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
----
G
-
E
V
K
L
A
D
F
G
V
A
--------------------------
G
Q
L
T
D
T
Q
I
K
R
N
-----
E
F
V
G
T
P
F
W
M
A
P
E
V
I
-
K
Q
-------------
S
A
Y
D
S
K
---------
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
----
H
P
M
K
V
L
F
L
I
-
P
K
N
N
P
P
T
L
E
-
G
N
Y
S
K
--
P
-
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
-----
K
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
74.15
26%
11
- C1 -
-
3I6U
-
CHK2_HUMAN
A:
[89-483]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
A
P
W
A
R
L
W
A
L
Q
D
G
F
A
N
L
E
C
V
----
N
D
N
Y
W
F
G
R
D
K
S
C
E
Y
C
F
D
E
P
LLKRTDKYR
T
Y
S
K
K
H
F
R
I
F
R
E
V
G
P
---------------------
K
N
S
Y
I
A
Y
I
E
D
H
S
G
N
G
T
F
V
N
T
E
L
V
G
K
G
K
R
R
P
L
N
N
N
S
E
I
A
L
S
L
S
R
N
K
V
F
V
F
F
D
L
T
-------------------------------------------------------------------------
V
------
D
D
Q
-------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
R
I
I
S
K
R
K
F
A
I
G
----------------
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
----
R
L
K
E
A
--
T
----
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
QEE
D
----
C
-
L
I
K
I
T
D
F
G
H
S
K
I
L
G
-------------------------------------------
P
T
Y
L
A
P
E
V
L
-
V
-----------------------
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
--
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
-
W
A
E
V
S
--
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
-----
E
E
A
L
R
---
H
-----------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.91
29%
-84
- C1 -
-
4W8D
1
STK24_HUMAN
A:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
----
P
L
D
E
T
--
Q
----
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
----
G
-
E
V
K
L
A
D
F
G
V
A
--------------------------
G
Q
L
T
D
T
Q
I
K
R
N
T
-----
F
V
G
T
P
F
W
M
A
P
E
V
I
-
K
Q
-------------
S
A
Y
D
S
K
---------
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
----
H
P
M
K
V
L
F
L
I
-
P
K
N
N
P
P
T
L
E
-
G
N
Y
S
K
--
P
-
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
-----
K
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.46
29%
-84
- C1 -
-
3A7F
-
STK24_HUMAN
A:
[28-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
----
P
L
D
E
T
--
Q
----
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
----
G
-
E
V
K
L
A
D
F
G
V
A
--------------------------
G
Q
L
------
R
N
T
-----
F
V
G
T
P
F
W
M
A
P
E
V
I
-
K
Q
-------------
S
A
Y
D
S
K
---------
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
----
H
P
M
K
V
L
F
L
I
-
P
K
N
N
P
P
T
L
E
-
G
N
Y
S
K
--
P
-
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
-----
K
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.46
29%
-85
- C1 -
-
4U8Z
1
STK24_HUMAN
A:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
----
P
L
D
E
T
--
Q
----
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
----
G
-
E
V
K
L
A
D
F
G
V
A
--------------------------
G
Q
L
T
D
T
Q
I
K
R
N
T
-----
F
V
G
T
P
F
W
M
A
P
E
V
I
-
K
Q
-------------
S
A
Y
D
S
K
---------
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
----
H
P
M
K
V
L
F
L
I
-
P
K
N
N
P
P
T
L
E
-
G
N
Y
S
K
--
P
-
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
-----
K
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.41
29%
-82
- C1 -
-
4W8E
1
STK24_HUMAN
A:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
----
P
L
D
E
T
--
Q
----
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
----
G
-
E
V
K
L
A
D
F
G
V
A
--------------------------
G
Q
L
T
D
T
Q
I
K
R
N
T
-----
F
V
G
T
P
F
W
M
A
P
E
V
I
-
K
Q
-------------
S
A
Y
D
S
K
---------
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
----
H
P
M
K
V
L
F
L
I
-
P
K
N
N
P
P
T
L
E
-
G
N
Y
S
K
--
P
-
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
-----
K
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
73.10
29%
-81
- C1 -
-
3A7I
1
STK24_HUMAN
A:
[28-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
----
P
L
D
E
T
--
Q
----
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
----
G
-
E
V
K
L
A
D
F
G
V
A
--------------------------
G
Q
L
T
D
T
Q
I
K
R
N
T
-----
F
V
G
T
P
F
W
M
A
P
E
V
I
-
K
Q
-------------
S
A
Y
D
S
K
---------
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
----
H
P
M
K
V
L
F
L
I
-
P
K
N
N
P
P
T
L
E
-
G
N
Y
S
K
--
P
-
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
-----
K
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.77
29%
-84
- C1 -
-
3ZHP
-
STK24_HUMAN
C:
[33-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
----
P
L
D
E
T
--
Q
----
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
----
G
-
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-------------
D
T
---
R
N
T
------------------
F
V
G
T
P
F
W
M
A
P
E
V
I
-
K
Q
-------------
S
A
Y
D
S
K
---------
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
----
H
P
M
K
V
L
F
L
I
-
P
K
N
N
P
P
T
L
E
-
G
N
Y
S
K
--
P
-
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
-----
K
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------
45
Fugue
70.13
19%
-38
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
--
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
---
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
----
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
------------------
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
-------------
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
-
Y
N
V
D
----
E
D
N
P
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
-
D
D
---
D
----
G
-
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
-------------------------------
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
-
L
G
E
E
Y
D
----------------------
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
-
L
E
Q
A
V
T
Y
P
D
-
K
F
S
----
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
RDGSC
D
G
L
R
T
HPL
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
SRTVY
A
K
N
G
A
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
---------------------------------------------------
31
HHSearch
70.02
25%
-75
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
E
Y
Q
L
F
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
--------------
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
----
Y
Y
S
E
A
--
D
----
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
-
A
S
---
K
SKG-
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
-------------------------------
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
K
----------------------
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
--
L
Y
Q
Q
I
K
A
-
G
A
Y
D
F
P
S
P
E
-
W
D
T
V
T
--
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
-----
S
E
A
L
K
---
H
-----------------------------------------------------------------------------------------------------------------------------
38
HHSearch
68.86
24%
-50
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
Y
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
---------
R
R
-
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
E
----
S
L
T
E
E
--
E
----
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
-
L
D
---
R
NVP
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
--------------------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
----------------------
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
--
E
T
L
A
N
V
S
A
-
V
N
Y
E
F
E
D
E
Y
-
F
S
N
T
S
--
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
-----
Q
D
S
L
Q
---
H
-----------------------------------------------------------------------------------------------------------------------------
29
HHSearch
68.13
26%
-58
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[23-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
-
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
-----------
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
-
V
K
R
A
D
A
G
F
V
Y
S
E
A
--
V
----
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
-
A
S
---
K
ENS-
A
-
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
-------------------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-
K
R
----------------------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
---
L
F
E
G
I
I
K
-
G
K
Y
K
M
N
P
R
Q
-
W
S
H
I
S
--
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
-----
Y
E
A
L
N
---
H
-----------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
63.44
31%
-13
- C1 -
-
2CLQ
1
M3K5_HUMAN
A:
[29-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------------
P
E
R
D
---
S
Q
--
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
----
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
----
G
-
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------------------------------------
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
---------------------
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
-
F
K
V
H
-
P
E
I
P
-
E
S
M
S
A
--
E
A
K
A
F
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
-----
N
D
L
L
----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
62.98
30%
-21
- C1 -
-
4BIB
3
M3K5_HUMAN
A:
[26-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------------
P
E
----------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
----
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
----
G
-
V
L
K
I
S
D
F
G
T
S
K
R
---------------------------------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
---------------------
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
-
F
K
V
H
-
P
E
I
P
-
E
S
M
S
A
--
E
A
K
A
F
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
-----
N
D
L
L
----
V
D
E
F
L
K
------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.18
30%
-24
- C1 -
-
4BIE
2
M3K5_HUMAN
A:
[26-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------------
P
E
----------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
----
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
----
G
-
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
-------------------------------------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
---------------------
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
-
F
K
V
H
-
P
E
I
P
-
E
S
M
S
A
--
E
A
K
A
F
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
-----
N
D
L
L
----
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
60.98
31%
-21
- C1 -
-
5V24
1
M3K5_HUMAN
A:
[16-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------------
P
E
R
D
S
------
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
----
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
----
G
-
V
L
K
I
S
D
F
G
T
S
K
R
L
----------------------------------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D-----
Y
G
---------------------
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
---
E
P
Q
A
A
M
F
K
V
G
M
-
F
K
V
H
-
P
E
I
P
-
E
S
M
S
A
--
E
A
K
A
F
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
-----
N
D
L
L
----------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
59.71
30%
-19
- C1 -
-
4BID
1
M3K5_HUMAN
A:
[26-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------------
P
E
----------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
----
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
----
G
-
V
L
K
I
S
D
F
G
T
S
K
R
---------------------------------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
---------------------
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
-
F
K
V
H
-
P
E
I
P
-
E
S
M
S
A
--
E
A
K
A
F
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
-----
N
D
L
L
----
V
D
E
F
L
K
------------------------------------------------------------------------------------------------------------------------