@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_07_0320: (2018-03-07 )
MGMEHYTKVKDLGGTNGAFLARDRQQPDRLVVIKRLADGTQGIEELNASLRLRHPHIVRFLESFVYNGSLFVVMSYESGGDLDGLFHYLTQSHRTPTTHTLLLWFVQLLEALAYCHDSHVIHRDIKPSNILVSEDTKVLYLGDFGSAKTLSTSNVTSTFVGSPMWISPEVLLGTSYGYAADVWSMGCVFYEMATLRKPFSAPSFAHLVQQITWGHITPLPAHVAQEVRSIIHSMLVLDPAQRVTAKAALEVARGALGRAEELRQASPSPLRPAGMPSKSSATSLPPRLTSPPEVVAHQPRQTPPPPSPPPSQPYSSCPSASSTTPPRKGGLTQTAAPPVPTPSDSTPPASSTVSDPLLVVASEAKAGEDPTPHGSPPSAAAPEFSSQAAVVKQRPGASSPASILEEPTASPTPQPPVGGAPASMQPPAVLVVAAAPPAPAAKKEATVRDKGAPAASPVVDAQLRVPQQMVLQISTTGFSKPAQRKKAAPKRKNVATHKAGPLPLRQRVPSVPAPTSPPTEAPKFVRQLSTDSLSSRRAAELFAPSRGSSGPTKVVVKAVPPAHVAKRALAVAGNRENPPRVPKESPTREARALQKAPLKPALQLPPKPAAPPSDAAPADQWFDQRMRDLCAMENYLHQHRVDDDKVLQTYDARRHKEEQQCESATPGTRAAGRPPAARRRSPATKFASPAQPPGVLVMTPPRHRHLSEGIPAPPALPAAQQQQQRQQRPGAASPFVRQASYVCQGLHPACRSESRQSSLSSTFNGRQASNARARARVSLEEQLKNEEGRVIAREKREAERQRMKELISAQRAAAKQQKRKARKDDAVDVQIVLPDRLHYAPDSAVPAD
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------.........10..-....-..20.......------.30.....--------...-------------40-------..-------.......50-------.-.......60....--.------...70........80........90.........100.......110.....-.-.120.......130-....--...140.......150..-.--.....160.......170------..-----.....180.......190.......200.......210---.---..----------------------------..---.---..220.......230.......240.-----......250--------------......---...260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------MGM
E
H
Y
T
K
V
K
DLG-GTNG-
A
F
L
ARDRQQP
D
------
R
L
V
V
I
K
R
L--------ADG-------------T--------
Q
G
-------
I
E
E
L
N
A
S
L
R-------L-R
H
P
H
I
V
R
F
L
E
S
F
V--Y------N
G
S
L
F
V
V
M
S
YESGG
D
L
D
G
L
F
H
Y
L
T
-QSHRTP
T
T
H
T
L
L
L
W
F
V
Q
L
L
E
A
L
A
Y
C
HD-S-
H
V
I
HRDIKPS
N
I
L
V-SED
T
--
K
V
L
Y
L
GDFGSA
K
T
L-STS-N--V
T
S
TFVGSPMWISPE
V
L
L
------GT-----SYGY
A
A
D
V
W
S
M
G
C
V
F
Y
E
M
A
T
L
RKPFSA
P
S
F
A
H
L
V
Q
Q
I
----T---WG----------------------------HI---T---P
L
P
A
H
V
A
Q
E
V
R
S
I
I
H
S
M
L
VLD
P
A
Q
R
V
-----
T
A
K
A
A
L
E
----------------
V
A
R
GAL---G
R
A
E
E
L
R
QASPSPLRPAGMPSKSSATSLPPRLTS
P
P
E
V
VAHQPRQTPPPPSPPPSQPYSSCPSASSTTPPRKGGLTQTAAPPVPTPSDSTPPASSTVSD
P
L
L
V
V
ASEAKAGEDPTPHGSPPSAAAPEFSSQ
A
A
V
V
KQRPGAS
S
P
A
S
I
LEEPTASPTPQPPVGGAPASMQP
P
A
V
L
V
V
AAAPPAPAAKKEATVRDKGAPAASP
V
V
D
AQLRV
P
Q
Q
M
V
L
Q
I
STTGFSK
P
A
Q
R
KKAAPKRKNVATHKAGPL
P
L
R
Q
RVPSVPAPTSPPT
E
A
P
K
F
V
R
Q
LSTDSLSSR
R
A
A
E
LFAPSRGSSGP
T
K
V
V
V
K
AV
P
P
A
H
V
A
K
R
A
L
A
VAGNRENPPRVPKESP
T
R
E
A
R
A
L
Q
KAPLKPALQLPPKPAAPPSDAA
P
A
D
Q
W
F
D
Q
R
M
R
D
L
C
A
M
E
N
Y
L
H
Q
HRV
D
D
D
K
V
L
Q
T
Y
D
A
R
R
H
K
E
E
Q
Q
CESATPGTRAAGRPPAARRRSPATKFASPAQPP
G
V
L
V
MTPPRH
R
H
L
SEGIPAPPALP
A
A
Q
Q
Q
Q
Q
R
Q
QRPGAAS
P
F
V
R
Q
A
S
Y
V
C
QGL
H
P
A
C
R
S
E
S
R
Q
S
S
L
S
STFNGRQASNA
R
A
R
A
R
V
S
L
E
E
Q
LKNEEG
R
V
I
A
R
E
K
R
E
A
E
R
Q
R
M
K
E
L
I
S
A
Q
R
A
A
A
K
Q
Q
K
R
KARKDD
A
V
D
V
Q
I
VLPDRLHYAPDSAVPAD
51
Fugue
71.61
29%
-15
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
IV
K
E
G
W
L
H
K
R
GEYIT
W
R
P
R
Y
F
L
L
K
NDG
T
F
I
G
Y
KERPAPLNNFSVAQ
C
Q
L
M
K
T
ERPRPN
T
F
I
I
R
C
LQWT
T
V
I
E
R
T
F
H
V
ET
P
E
E
R
E
E
W
T
T
A
I
QR
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
-
K
V
I
L
V
K
E
K
A
T
G
------
R
Y
Y
A
M
K
I
L
--------
K
K
V
-------------
L
--------
Q
----------------
N
-------
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
--
T
------
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
---
L
F
F
H
L
S
-
R
E
-
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
-
D
K
D
G
--
H
-
I
K
I
T
D
F
G
L
C
-------------------
P
E
Y
L
A
P
E
V
L
E
------
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
----
L
---
M
E
----------------------------
E
I
-------
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GG---
G
S
E
D
A
K
E
----------------
I
M
Q
H
R
F
---
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
64.97
30%
-24
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[54-344]
-----------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
-
S
G
------
E
L
V
A
I
K
K
V
--------
L
Q
D
-------------
K
R-------
F
K
-------
N
R
E
L
Q
I
M
R
K
-------
L
-
D
H
C
N
I
V
R
L
R
Y
F
F
Y
--
S
S
GEKKD
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
--
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
-
F
-
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
-
D
P
D
T
--
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
-
V
R
G
-
E
--
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
------
G
A
T----
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
----
I
---
K
V
LGTPT
R
E
Q
I
R
E
M
NPNYTEFKFPQIKAHP
W
T
---
K
---
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
-----
T
P
L
E
A
C
A
----------------
H
S
F
F
D
E
---
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
64.38
23%
14
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
----------------------S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
GPAQTNGQCFS
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
SPLRRE
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
-
E
V
A
V
V
K
L
K
N
A
D
------
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
-------------
A
--------
C
F
-------
R
E
E
R
D
V
L
V
N
-------
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
--
D
------
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
---
L
L
T
L
L
S
-
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
-
D
M
N
G
--
H
-
I
R
L
A
D
F
G
S
C
L
K
L
-
M
E
D
-
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
------
A
M
E
GGKG
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
HK
E
---
R
F
----------------------------
Q
F
---
P
---
T
Q
V
T
D
V
S
E
N
A
K
D
L
I
R
R
-
L
I
C
S
R
E
H
R
L
-----
G
Q
N
G
I
E
D
----------------
F
K
K
H
P
F
FSG
I
D
W
D
N
I
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
61.79
29%
-37
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[6-281]
---------------------------------------------------------------------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-
T
G
------
R
Y
Y
A
M
K
I
L
--------
K
K
E
-------------
V
I
V
A
K
DE
V
A
H
T
-------
L
T
E
N
R
V
L
Q
N
-------
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
--
T
------
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
-
D
K
D
G
--
H
-
I
K
I
T
D
F
G
L
C
K
E
G
-
I
K
D
G
A
--
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
----
L
---
M
E
----------------------------
E
I
-------
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
----------------
H
R
F
F
A
G
---
I
V
W
Q
H
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
58.53
28%
-23
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[23-293]
----------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
-
T
G
------
Q
Q
F
A
V
K
I
V
--------
D
V
A
K
F
T
S
SPGLS
T
---
E
--------
D
L
-------
K
R
E
A
S
I
C
H
M
-------
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
--
S
------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
-
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
-
A
S
K
E
NS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
E
S
-
G
L-
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
-----
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
----
I
---
K
G
----------------------------
K
Y
K
M
N
P
---
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
----------------
H
P
W
L
K
E
---
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.36
32%
-6
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[6-267]
-----------------------------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
-
R
C
Q
K
I
R
R
K
S
D
G
------
K
I
L
V
W
K
E
L
--------
D
Y
G
-------------
S
--------
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-------
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
------
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
-
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-
S
-
L
H
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
--
N
V
-
K
L
G
D
F
G
L
A
R
I
L
---
T
-
S
--
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
----
R
---
E
G
----------------------------
K
F
---
R
---
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
56.08
28%
-23
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[23-293]
----------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
-
T
G
------
Q
Q
F
A
V
K
I
V
--------
D
V
A
K
F
T
S
SPGLS
T
---
E
--------
D
L
-------
K
R
E
A
S
I
C
H
M
-------
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
--
S
------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
-
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
-
A
S
K
E
NS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
E
S
-
G
L
-
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
-----
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
----
I
---
K
G
----------------------------
K
Y
KMN
P
---
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
----------------
H
P
W
L
K
E
---
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
53.17
18%
2
- C1 -
-
1KOB
1
?
A:
[23-374]
-------------------------------------------------------------------INDYDKFYEDIWKK
Y
V
P
Q
P
V
E
V
K
QG
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
-
S
G
A
F
-
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
--------
L
D
K
-------------
Y
--------
T
V
-------
K
N
E
I
S
I
M
N
Q
-------
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
--
D
------
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
---
L
F
D
R
I
A
-
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
-
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
A
--
S
S
V
K
I
I
D
F
G
L
A
T
K
L
-
N
P
D
-
E
--
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
-----
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
----
K
R
C
D
W
E
----------------------------
F
D
---
E
---
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
-----
T
V
H
D
A
L
E
HPWLKGDHSNLTSRIP
S
S
R
Y
N
K
---
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
51.04
34%
-13
- C1 -
-
4APC
-
NEK1_HUMAN
A:
[23-276]
----------------------------------------------------------------------------------------------
M
E
K
Y
V
R
L
Q
K
I
-------
K
A
I
L
V
K
S
T
E
D
G
------
R
Q
Y
V
I
K
E
I
--------
N
I
S
-------------
R
--------
M
S
-------
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
R
E
S
F
E
--
E
------
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
---
F
K
R
I
N
A
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
-
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
-
T
K
D
G
--
T
V
-
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
-
E
--
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
------
N
K
-----
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
----
I
---
S
G
----------------------------
S
F
---
P
---
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
50.09
28%
-7
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[10-274]
----------------------------------------------------------------------------------------------
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
-
T
G
------
L
E
F
A
A
K
I
I
--------
N
T
K
-------------
K
LS
A
R
D
F
Q
-
K
L
-------
E
R
E
A
R
I
C
R
K
-------
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
--
E
------
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
-----
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
-
N
-
G
I
V
H
R
N
L
K
P
E
N
L
L
L
-
A
S
K
A
KG
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
N
D
S
-
E
--
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
-----
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
A
Q
I
----
K
---
A
G
----------------------------
A
Y
---
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
-----
T
A
D
Q
A
L
K
----------------
V
P
W
I
C
N
---
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
50.06
34%
-14
- C1 -
-
4B9D
1
NEK1_HUMAN
A:
[23-276]
----------------------------------------------------------------------------------------------
M
E
K
Y
V
R
L
Q
K
I
-------
K
A
I
L
V
K
S
T
E
D
G
------
R
Q
Y
V
I
K
E
I
--------
N
I
S
-------------
R
--------
M
S
-------
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
R
E
S
F
E
--
E
------
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
---
F
K
R
I
N
A
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
-
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
-
T
K
D
G
--
T
V
-
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
-
E
--
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
------
N
K
-----
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
----
I
---
S
G
----------------------------
S
F
---
P
---
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
50.05
32%
-2
- C1 -
-
2XNN
6
NEK2_HUMAN
A:
[6-267]
-----------------------------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T--
Y
G
-
R
C
Q
K
I
R
R
K
S
D
G
------
K
I
L
V
W
K
E
L
--------
D
Y
G
-------------
S
--------
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-------
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
------
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
-
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-
S
---
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
--
N
V
-
K
L
G
D
F
G
-----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
----
R
---
E
G
----------------------------
K
F
---
R
---
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
49.75
32%
6
- C1 -
-
2XNP
6
NEK2_HUMAN
A:
[6-267]
-----------------------------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
-
R
C
Q
K
I
R
R
K
S
D
G
------
K
I
L
V
W
K
E
L
--------
D
Y
G
-------------
S
--------
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-------
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
------
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
-
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-
S
--
H
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
--
N
V
-
K
L
G
D
F
G
L
----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
--------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
----
R
---
E
G
----------------------------
K
F
---
R
---
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
49.57
32%
-8
- C1 -
-
2XNM
10
NEK2_HUMAN
A:
[6-267]
-----------------------------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
-
R
C
Q
K
I
R
R
K
S
D
G
------
K
I
L
V
W
K
E
L
--------
D
Y
G
-------------
S
--------
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-------
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
------
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
-
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-----
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
--
N
V
-
K
L
G
D
F
G
L
A
R
I
L
------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
----
R
---
E
G
----------------------------
K
F
---
R
---
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
49.45
32%
-19
- C1 -
-
2XK6
1
NEK2_HUMAN
A:
[6-267]
-----------------------------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
------
R
C
Q
K
I
R
R
K
S
D
G
------
K
I
L
V
W
K
E
L
--------
D
Y
G
-------------
S
--------
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-------
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
------
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
-
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-
S
---
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
--
N
V
-
K
L
G
D
--------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
--------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
----
R
---
E
G
----------------------------
K
F
---
R
---
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
49.14
32%
-3
- C1 -
-
2XK7
1
NEK2_HUMAN
A:
[6-267]
-----------------------------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
----
R
C
Q
K
I
R
R
K
S
D
G
------
K
I
L
V
W
K
E
L
--------
D
Y
G
-------------
S
--------
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-------
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
------
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
-
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-
S
---
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
--
N
V
-
K
L
G
D
F
-------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
----
R
---
E
G
----------------------------
K
F
---
R
---
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
49.10
32%
-0
- C1 -
-
2XK8
1
NEK2_HUMAN
A:
[6-267]
-----------------------------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T-----
R
C
Q
K
I
R
R
K
S
D
G
------
K
I
L
V
W
K
E
L
--------
D
Y
G
-------------
S
--------
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-------
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
------
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
-
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-
S
---
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
--
N
V
-
K
L
G
D
F
------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
----
R
---
E
G
----------------------------
K
F
---
R
---
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
48.69
24%
-28
* C1 *
-
2Y7J
1
PHKG2_HUMAN
C:
[94-364]
-----------------------------------------------------------------------------------------------
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
-
T
G
------
H
E
F
A
V
K
I
M
--------
E
V
T
AERLSPEQLEEVR
E
--------
A
T
-------
R
R
E
T
H
I
L
R
Q
-------
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
--
S
------
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
-----
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
D
D
N
M
--
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
-
E
P
G
-
E
--
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
-----
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
----
M
---
E
G
----------------------------
Q
Y
---
Q
FSS
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
----------------
H
P
F
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
48.34
32%
-3
- C1 -
-
2XKF
1
NEK2_HUMAN
A:
[6-267]
-----------------------------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
----
R
C
Q
K
I
R
R
K
S
D
G
------
K
I
L
V
W
K
E
L
--------
D
Y
G
-------------
S
--------
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-------
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
------
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
-
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-
S
---
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
--
N
V
-
K
L
G
D
F
------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
----
R
---
E
G
----------------------------
K
F
---
R
---
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
48.22
32%
4
- C1 -
-
2XNO
13
NEK2_HUMAN
A:
[6-267]
-----------------------------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
-
R
C
Q
K
I
R
R
K
S
D
G
------
K
I
L
V
W
K
E
L
--------
D
Y
G
-------------
S
--------
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-------
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
------
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
-
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-
S
---
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
--
N
V
-
K
L
G
D
F
------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
--------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
----
R
---
E
G
----------------------------
K
F
---
R
---
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------