@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_07_0330: (2018-03-07 )
MPPQPLAQCQRSKQPSPTATETMITSEYKIVEKMATGSFGVVFKVRRVTDHQVFVMKRIPLLGLTAPQRRDAAQEIILMRDLHHPCVVSQRDAFLYNEHDLCLVMDYYDGGDMDTHMAAQRDLDMYFELDQVMLWFVQLVLGAQYLHAHNVVHRDIKIHNVFVRSKDMSVVLGDFGISERLGVDLANHTWVAAATMSGPHGSDGSSLTSVPAMVTATAAGSPSPARMNRGDDAMRSLSISGGLRPSTPGGAGAGAPVLSPLLYQQTAWSSGQWGAGSQLCSPNSSPYQPLSHMRQTGASSNAASSCSLQRLLNGGVEAAMKGTPLYMAPEVLQGGAASPKSDVWSLGCVLYELLALRHPFESRDLAPLVMRVLRGQREPLPAHYPRPIADLINCMLCLDASQRPSCEEVLTVPCVRAYVDLWRSLRTPLDVPASPGESALMRQLQAWQANVAAWNARHPDDPRSKSVHYTELKRQLLSPACAPAEEREKVERRAVEAARTALLTAQPSGLTCSISSAAISGAIQGDGGVHDGTFFFGATGECLTGAAGRRSSELSSLPSAREGMNMGPSDSMRPYMVYDVAPEIAATAAAEGAGPSCAESAANKALNGRPPRPSRRPSGSPPPHPVQGEDLTVTGHNIGKGGARVGSLPQAANAARSEDSPMMSAAARKRRHPQARQLEPAAPQQRGESSRHDDTTEPERKPLTGVASPTIDGAAEAQSTTPPVPSSNFPLKPGLPTSPPLMHKRGATRCGSIDEDALFFQAYENVADMRFASLDEIAQSVVDLRQRVQQRMRHQRLLTDIEVLHERHGSALLRSMPHVLNVFEAAAAAEDGAEGPPGRSGGAQSTMSPEEAYARMVQQIDEQRSGHEQHQLDPDNAEKVVSILHLGQLPVGRPMPPRIRQLRESAALAQVAASEEARRRSRLLPRRSKDRSSSTTKRGVSFSAAVSMQFADPAAPLMASSTGGGRSSSLATAMELRRWRPYLERRNRLSAALTRVFDATTLRAVYSYYRTCALLQRDAAVVRRLVPDRQQWSALPSIEELAVLDRRLEVMFEDRPSWDGRQGA
Atome Classification :
(20 SA)
----------------------------------------........-----.10......-------------..20....-------------------....30.-.......40........50........60...---.------....70........80.-.......90..-----...-...100.......110.......120.......130.......140......-.-150.......160...-.--.---..170.....------..180------...------.....190.......200.......210.......220---........230.......240.......250.......260.....---..270-........280.......290...---------------....300.......310.......320.......330.------...----...340.......350.......360.......370...---..----------------------------.----.---380.......390.......400--..-----.....410--.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.....-..520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------MPP
Q
P
L
A
Q
-----
C
Q
RSKQPSP-------------TAT
E
T
M
IT-------------------
S
E
Y
K
I
V
E
-
K
MATGS
F
G
V
V
F
K
V
R
RVTD
H
Q
V
F
V
M
KRIPLLGL---T------
A
P
Q
R
R
D
A
A
Q
E
I
I
L
M
RDL-HHPCVVSQR
D
A
-----
F
L
Y-NEH
D
L
C
L
V
M
D
YYDGGDM
D
T
H
M
A
A
Q
R
D
L
D
M
Y
F
E
L
D
Q
V
M
L
W
F
V
Q
L
V
L
G
A
Q
Y
L
H
A
-H-NVVHR
D
I
K
I
H
N
V
F
V
RS-K--
D
---
M
S
V
V
L
GDFGI------
S
E
RL-------GVD------LAN
H
T
W
V
A
A
A
TMSGPHGSDGSSLTSV
P
A
M
V
T
ATAAGS----PSPARMNRG
D
D
A
M
R
S
L
SISGGLRPSTPGGAGAG
A
P
V
L
S
P
L
L
Y
Q
QTA---WSSG--QWGAGSQLCSPNSSPY
Q
P
L
S
H
M
R
Q---------------TGASSNA
A
S
S
C
S
L
Q
R
L
L
NG
G
V
E
A
AMKGTPLYM
A
P
E
V
LQ------GGA----ASPK
S
D
V
W
S
L
G
C
V
L
Y
E
L
L
A
L
RHPFESR
D
L
A
P
L
V
M
R
V
LRG---QR----------------------------E----P---LPAHYPR
P
I
A
D
L
I
N
C
M
L
CLDASQ--RP-----
S
C
E
E
V
L
T
V
--
P
C
V
R
A
Y
V
D
L
W
R
S
LRTPLDVPASP
G
E
S
A
L
M
R
Q
L
Q
A
W
Q
A
NVAAWNARHPDDPRSKSV
H
Y
T
E
L
K
R
Q
LLSPACA
P
A
E
E
R
E
K
V
E
R
R
A
V
E
A
A
R
T
A
L
L
TAQPS
G
L
T
C
S
ISSA-
A
I
S
G
A
IQGDGGVHD
G
T
F
F
FGATG
E
C
LTGAAGRRS
S
E
L
S
SLPSAREGMNMGPSDSM
R
P
Y
M
V
Y
DVA
P
E
I
A
A
T
AAAEGAGP
S
C
A
E
S
A
A
NKALNGRPPRPSRRPSGSPPPHPVQGE
D
L
T
V
TGHNIGKGGARVGSLP
Q
A
ANAARSEDS
P
M
M
S
A
A
A
R
KRRHPQARQLEPAAPQQRGESSRHDDTTEPERKPLTGVASPTIDGAAEAQSTTPPVPSSNFPLKPGLPTSPP
L
M
HKRGATRCGSID
E
D
A
L
F
F
Q
A
Y
E
N
V
A
D
M
R
F
A
S
L
D
E
I
A
Q
S
V
V
D
L
R
Q
R
V
Q
Q
R
M
R
H
Q
R
L
L
T
D
I
E
V
L
H
E
RH
G
S
A
L
L
R
S
M
P
H
V
L
N
V
F
E
A
A
AAAEDGAEGPPGRSGGAQSTM
S
P
E
E
A
Y
A
R
M
V
Q
Q
I
D
E
QRSGHEQHQLDP
D
N
A
E
K
V
V
S
I
L
H
LGQLPVGRPM
P
P
R
I
R
Q
L
R
E
S
A
A
L
A
Q
V
A
A
S
E
E
A
R
R
R
S
RLLPRRSKDRSSSTTKRG
V
S
F
S
A
A
V
S
M
Q
FADPAAP
L
M
ASSTGGGRS
S
S
L
A
T
A
M
E
L
R
R
W
R
P
Y
L
E
R
R
N
R
L
S
A
A
L
T
R
V
F
D
A
T
T
L
R
A
V
Y
S
Y
Y
R
T
C
A
L
L
Q
R
D
A
A
V
V
R
R
LVP
D
R
Q
Q
W
SALP
S
I
E
E
L
A
V
L
D
R
R
L
E
V
MFEDRPSWDGRQGA
43
HHSearch
87.78
33%
-76
- C1 -
-
2W5B
1
NEK2_HUMAN
A:
[4-275]
---------------------------------------------------------------------------------
R
A
-------------------
E
D
Y
E
V
L
Y
-
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
---
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-----
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
-
K
------
Q
N
V
K
L
G
D
F
G
L
------
A
R
I
L
-------
N
H
D
------
T
-------------------------------------------------------
S
--------------------------------------------------------------------------------------------------
F
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
---
K
F
----------------------------
R
----
R
---
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
--
P
L
I
L
E
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
86.42
33%
-163
- C1 -
-
4B9D
2
NEK1_HUMAN
B:
[22-284]
---------------------------------------------------------------------------------
S
M
-------------------
E
K
Y
V
R
L
Q
-
K
I
G
-----
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
---
S
------
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
R
E
S
-----
F
E
E
--
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
--
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
-
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
-
D
------
G
T
V
Q
L
G
D
F
G
I
------
A
R
V
L
-------
N
S
T
------
V
-------------------------------------------------------
E
--------------------------------------------------------------------------------------------------
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
------
N
K
P
----
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
---
S
F
----------------------------
P
----
P
---
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
--
R
P
-----
S
V
N
S
I
L
E
K
--
G
F
I
A
K
R
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
79.15
27%
-86
- C1 -
-
3KK8
-
KCC2D_CAEEL
A:
[3-270]
--------------------------------------------------------------------------------
K
F
S
-------------------
D
N
Y
D
V
K
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
---
S
------
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
-----
I
Q
E
--
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
-
N
-
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
-
K
--
A
KG-
A
A
V
K
L
A
D
F
G
L
------
A
I
E
V
-------
N
D
S
------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
P
----
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
---
A
Y
----------------------------
D
Y
P
S
-
P
---
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
--
R
I
-----
T
A
D
Q
A
L
K
V
--
P
W
I
C
N
R
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
78.10
27%
-53
* C1 *
-
3C0I
1
CSKP_HUMAN
A:
[21-295]
--------------------------------------------------------------------------------
L
F
E
-------------------
D
V
Y
E
L
C
E
-
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
------
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
-----
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
EN
S
---
A
P
V
K
L
G
G
F
G
V
------
A
I
Q
L
-------
G
E
S
------
G
-------------------------------------------------------
L
--------------------------------------------------------------------------------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
----
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
G
---
K
Y
----------------------------
K
M
N
P-
R
---
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
-----
T
V
Y
E
A
L
N
H
--
P
W
L
K
E
R
D
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
77.73
27%
-51
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[21-295]
--------------------------------------------------------------------------------
L
F
E
-------------------
D
V
Y
E
L
C
E
-
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
------
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
-----
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
EN
S
---
A
P
V
K
L
G
G
F
G
V
------
A
I
Q
L
-------
G
E
S
------
G
-------------------------------------------------------
L
--------------------------------------------------------------------------------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
----
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
G
---
K
Y
----------------------------
K
MNP-
R
---
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
-----
T
V
Y
E
A
L
N
H
--
P
W
L
K
E
R
D
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
75.10
27%
-83
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[8-275]
--------------------------------------------------------------------------------
K
F
S
-------------------
D
N
Y
D
V
K
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
---
S
------
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
-----
I
Q
E
--
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
-
N
-
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
-
K
AK
G
---
A
A
V
K
L
A
D
F
G
L
------
A
I
E
V
-------
N
D
S
------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
P
----
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
---
A
Y
----------------------------
D
Y
P
S
-
P
---
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
--
R
I
-----
T
A
D
Q
A
L
K
V
--
P
W
I
C
N
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
74.26
22%
-108
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[10-302]
---------------------------------------------------------------------------------
V
M
-------------------
N
K
F
E
I
L
G
-
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
----------------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
-
K
Q
E
N
I
V
E
L
K
E
A
-----
F
R
R
--
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P
----
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
-
N
-
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
-
N
------
D
V
L
K
L
C
D
F
G
F
------
A
R
N
L
-------
S
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
W
Y
R
S
P
E
L
L
L
------
G
A
P
----
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
LGP
L
P
S
E
Q
M
K
L
F
Y
S
NPRFHGLRFPAV
N
H
P
Q
S
L
E
R
----
R
---
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
--
R
Y
-----
L
T
E
Q
C
L
N
H
--
P
T
F
Q
T
Q
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
70.45
25%
-90
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-270]
----------------------------------------------------------------------------------
Q
-------------------
E
D
F
E
L
I
Q
-
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
-----------
G
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
-----
Y
L
R
--
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
----
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
-
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
-
N
------
G
H
V
K
L
A
D
F
G
V
------
S
A
Q
I
-------
T
A
T
------
I
-------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER---
K
G
G
----
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
F
L
M
T
K
S
---
N
F
----------------------------
Q
P
P
KL
K
---
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
--
R
P
-----
T
A
E
K
L
L
Q
H
--
P
F
V
T
Q
H
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
70.08
25%
-34
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
---------------------------------------------------------------------------------
F
Y
-------------------
Q
K
Y
D
P
K
D
-
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
---
R
LSPEQL
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
-----
Y
E
S
--
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-
N
------
M
Q
I
R
L
S
D
F
G
F
------
S
C
H
L
-------
E
P
G
------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
---
Q
Y
----------------------------
Q
----
F
SSP
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
-----
T
A
E
Q
A
L
Q
H
--
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
69.82
22%
22
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
-------IV
K
E
G
W
L
H
K
R
GEYIT
W
R
P
R
Y
F
L
L
K
NDG
T
F
I
G
Y
K
E
R
P
A
P
L
N
N
FSVAQ
C
Q
L
M
K
T
E
R
P
RPN
T
F
I
I
R
C
LQWT
T
V
I
E
R
T
F
H
V
ET
P
E
E
R
E
E
W
T
T
A
I
QRVTM
N
E
F
E
Y
L
K
-
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
-------------------------
K
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
-----
F
Q
--
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
-
D
-
K
--
D
---
G
H
I
K
I
T
D
F
G
L
CPEYLA
P
E
V
L
E
DNDYG
R
A
V
D
------
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
----
P
R
T
L
G
-
P
E
A
K
S
L
L
S
G
L
-
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
--
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
68.93
25%
-49
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[5-279]
--------------------------------------------------------------------------------
V
T
M
-------------------
N
E
F
E
Y
L
K
-
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
------
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
-----
F
Q
T
--
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
----
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
-
D
------
G
H
I
K
I
T
D
F
G
L
------
C
K
E
G
-------
I
K
D
------
G
-------------------------------------------------------
A
--------------------------------------------------------------------------------------------------
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
---
E
I
---------------------------------
R
---
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
GGGS
E
D
A
K
E
I
M
Q
H
--
R
F
F
A
G
I
V
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
66.45
25%
-58
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[65-343]
-------------------------------------------------------------------------------
Q
M
K
A
-------------------
E
D
Y
D
V
V
K
-
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
--
K
------
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
-----
F
Q
D
--
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-----
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
-
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
-
H
------
G
H
L
K
L
A
D
F
G
T
------
C
M
K
M
-------
D
E
T
------
G
M
------------------------------------------------------
V
--------------------------------------------------------------------------------------------------
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
------
S
Q
G
GDGF
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
---
K
N
----------------------------
S
LCF-
P
---
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-----
G
V
E
E
I
R
Q
H
--
P
F
F
K
N
D
Q
W
H
W
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
66.28
23%
-101
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-351]
----------------------------------------------------------------------------------
R
-------------------
S
Y
L
D
N
F
I
-
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-----------
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
-----
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
------
G
R
V
K
L
S
D
F
G
F
------
C
A
Q
V
-------
S
K
E
------
V
-------------------------------------------------------
P
--------------------------------------------------------------------------------------------------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
P
----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
---
L
P
----------------------------
P
----
R
LK-
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
A
-----
T
A
A
E
L
L
K
H
--
P
F
L
A
K
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
65.72
25%
-30
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-364]
---------------------------------------------------------------------------------
F
Y
-------------------
Q
K
Y
D
P
K
D
-
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
------
R
LSPEQL
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
-----
Y
E
S
--
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-
N
------
M
Q
I
R
L
S
D
F
G
F
------
S
C
H
L
-------
E
P
G
------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
---
Q
Y
----------------------------
Q
----
F
SSP
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
-----
T
A
E
Q
A
L
Q
H
--
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
65.55
29%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[2-272]
---------------------------------------------------------------------------------
M
T
-------------------
D
E
Y
Q
L
F
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
---
S
------
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
-----
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
--
S
KG-
A
A
V
K
L
A
D
F
G
L
------
A
I
E
V
-------
Q
G
D
------
Q
-------------------------------------------------------
Q
--------------------------------------------------------------------------------------------------
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
----
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
---
A
Y
----------------------------
D
FPS-
P
---
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
--
R
I
-----
T
A
S
E
A
L
K
H
--
P
W
I
C
Q
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
65.38
25%
-87
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-350]
------------------------------------------------------------------------------------------------------
Y
T
V
S
K
T
E
-
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
-----------
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
-----
F
E
S
--
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
---
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
-
M
-
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
--
A
---
K
Q
I
K
I
I
D
F
G
L
------
A
R
R
Y
-------
K
P
R
------
E
-------------------------------------------------------
K
---------------------------------------------------------------------------------------------------
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
------
Y
D
F
----
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
---
R
W
----------------------------
D
LED-
E
---
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
--
R
I
-----
S
A
S
E
A
L
K
H
--
P
W
L
S
D
H
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
64.12
20%
-99
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[20-283]
---------------------------------------------------------------------------------
L
Y
-------------------
E
K
Y
M
I
A
E
-
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
------------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
-----
F
E
S
--
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
---
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
-
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
-
R
R-
S
---
S
T
I
K
I
I
E
F
G
Q
------
A
R
Q
L
-------
K
P
G
------
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
----
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
---
E
Y
----------------------------
T
FDE-
E
---
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
--
R
M
-----
T
A
S
E
A
L
Q
H
--
P
W
L
K
Q
K
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
63.96
21%
-12
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[8-279]
--------------------------------------------------------------------------------
N
V
D
-------------------
D
Y
Y
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
SSRR--
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
-----
Y
E
N
--
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
--
N
VP
K
P
R
I
K
I
I
D
F
G
L
------
A
H
K
I
-------
D
F
G
------
N
----------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
----
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
---
N
Y
EFE-------------------------
D
----
E
---
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
--
P
W
I
K
P
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
60.95
16%
-4
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
S
V
E
E
Y
L
V
H
A
L
QG
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
RSREPS
P
K
T
E
D
N
E
G
-----
V
L
L
T
E
K
L
K
P
-------------
V
D
Y
E
Y
R
E
E
-------------------
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
----------------
E
V
F
R
A
E
E
L
M
A
C
A
G
L
-
T
S
P
R
I
V
P
L
Y
G
A
-----
V
R
E
-
G
P
-
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
C
----
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
-
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
-
D
--
G
---
S
H
A
A
L
C
D
F
G
H
------
A
V
C
L
-------
Q
I
P
-------
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
----
H
-
P
W
T
Q
F
F
R
G
P
L
C
L
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
IHR
V
S
A
A
--
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
---------------
K
E
P
R
H
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
59.78
12%
-
- C1 -
-
3QA8
-
?
A:
[16-666]
---------------------------------------------------------------------------------------------------------
E
M
K
E
-
R
L
G
T
G
G
F
G
Y
V
L
R
W
I
H
Q
D
T
G
E
Q
V
A
I
K
Q
C
R
Q
-
E
L
---
S
------
P
K
N
R
E
R
W
C
L
E
I
Q
I
M
K
K
L
-
N
H
P
N
V
V
S
A
R
E
V
PDGLQ
K
L
A
-
P
N
D
L
P
L
L
A
M
E
Y
C
E
G
G
D
L
R
K
Y
L
N
Q
F
E
N
C
C
G
L
K
E
G
-
P
I
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
-
N
-
R
I
I
H
R
D
L
K
P
E
N
I
V
L
Q
P
-
G
--
P
Q
R
-
L
I
H
K
I
I
D
L
G
Y
------
A
K
E
L
-------
D
Q
G
ELCTEF
V
G
T
L
Q
Y
L
A
P
E
L
L
E
Q
K
K
Y
T
V
T
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
T
G
F
RPFL
P
N
W
Q
P
V
Q
W
H
G
K
V
R
I
V
V
Y
D
D
L
T
G
A
V
K
F
S
S
V
L
P
T
P
N
H
L
S
G
I
L
A
G
K
L
E
R
---
W
L
Q
C
M
L
M
W
H
Q
R
T
D
P
Q
N
P
N
V
G
C
F
Q
A
L
D
S
I
L
S
L
K
L
L
S
V
M
N
MVSGR
V
H
T
Y
P
V
T
E
N
E
N
L
Q
N
L
K
S
W
L
Q
Q
D
T
G
I
P
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
------
N
S
A
----
Q
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
D
N
R
K
I
S
L
P
A
H
P
E
S
V
S
I
V
L
Q
D
---
P
K
----------------------------
R
----
P
---
L
T
Y
T
H
L
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
--
C
A
-----
R
L
L
Q
G
Q
R
T
S
M
V
N
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
K
L
D
F
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
Q
M
E
F
G
I
T
S
E
K
L
L
S
A
W
R
E
M
E
Q
A
V
E
L
C
G
R
E
R
E
V
Q
A
L
V
D
K
M
M
A
L
Q
T
D
S
V
D
L
Q
R
N
P
T
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
R
P
R
D
Q
R
T
P
G
D
S
N
D
M
V
R
L
L
I
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
L
S
P
K
V
K
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
S
K
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------