@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
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Structural Clustering:
Cluster Num
3D-Jury Struct. Score
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Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
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Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_08_0530: (2018-03-08 )
MGTSRVHSTSGTAGARWNSISLGPRSIAGSTRGPHGLQCRRGFRVLHFLLACAIALHAVTAPLSTCYAYIRHAAAPPSITAETPAAPSLIRPNGLPPAAPAAPWRTLNESLLPYPVFYPAIALLNNSILLLGGCATATCATPVGASGTRVAASRHRASAATSVTSPYHERLLSLNVDKGNITTLPQLTLPSGLGFAGRYAAVTLTDSVYVARSCTMSTQSPAEVASMTAEELQAMQAAYAPVVAFYPEGTAHASTRVGGPDPPPAVNLTYFKVPADRVRVNASCTALATENKLLIIGGFLLSGKRVTASVDSFNVVTRKYDADVAFLTAPVLQPSVATSTGFAAVAGGWTYEADTTASATREARALQEESRVRRSSRVAVSGEPLHLVQELATPPGKSSASPRSDTPSSPPSRSVPSPAPLQPVARYLFDLLFFEPDRVRGCSRAVPRGALQIGGSICVSPVDSSTLPRTAVEDILLSPNGCHVAVFGGQVVLVDHNLGHIAALDIRARLAQAFAARAPLVLRPPPAVTLLRTAKPNAAARTFAGTESAASRDAQASSRHNDHAGSTAVFASSGSSSAAPMTSSTSSSSSATASSSSSSAPLPEYRYSWMQPTLISLPYARRPAPAAAPDPPVMADTILLYYALGGEDVWSQVVTAAGDSAAADLLDPSGRQHVVPQLHGDPSTLRATGKGTEAVVRREPTLRWAQRELPDVRYDRDRPELLAVTMPTPLWPDALTLQTNSEGIIHLAFRDLNYTRYCRWNRLVDNDDDNVVCAVRLSSRRDCVGNTAGTLDSAYDGSPNATILFSASGSTTPVYVCFSYVVRPTLWPTCRIRQSFSILNPMMPLRILDNSHTTSAPTPTPRPSPTRDPADKTTSSPLFMLAVGVSIVTLLVALLLAARLQHVPEDGLLVMSLLDRGDGAGDQHASPGIRGRSCGGAARHNGQGRRKRLLRGSGEPNKAADVEDDDEPGLYPISTYAEFLQVVGSAQEDSEARMLATAVDVLRLHQHRYRVLSRIGQGPHSLCFLALRKAPPPPPLRVQQQRVRGAGAGMNRRVRMLDGDASPVVRSSLFTRPPPSFPAASATLSPGVPTTATSSLWAARHDQSTAVVVKYTQCPDDATRALITRLCERLRDLQADAVTEALGATGVYRQHRNSAPSRRPHRRYRPSDTSTTVSSAAALRPLDVSTQLTCGIAREVASGGRSSRGGAAAQALQTDAEDATAPPTSRRDSSAIIVTTASRAGCQPLPPLSSAANEARVIDGDDDDNSCAWLDAHEVNVVLSLFLLLPEDLFVSYEVSVLQQQNSNSSSQHAHVDRSGRLTPLSVSQAAVEWNRRHVWPGANAEPAKASHHRQRHRCTPMLSAGQSLPEQSTPRVCWAACVNPLQPSTLRPWSLCLVMPYERSGDLADFILRCQQVQLLPADVTGAKDTKRTGLSSRTSASPACVPPVHHCWTESLLCSILFQVCTGLQLLHAQSPPILHGNIKQTNVLLREPASFSVARRRVVVAGTPAALAGMKMGVSSGRGGLEDANGDLDMAAATMRVPGAQQAREGEGGWRDRRLEAGIAAAARPLSAHASFWRASSLVAAATAVWQAGSPVLRSSLSIGSPPSLFRAGATASSSTAAFSHDAPQEGQPQLQPHEDEQLWPPERARHLLSTHTYLPISLTDGGMSWWLTVQLPLRLRGCFGRTTRSTLRQAPAGLCWLRRLDPPPSSPPPITTKSSVLPSEDCIAALADFLFTFIDVPTHVAPELLWGRLCTLSQSDHGDEGGAAAGLAVPGSSLTQSSSSLHSIRNRREQHVASSRRDGRRRGDGDSLTHRRCGDVAREPAASPAVGSANLLRATASDELGANVTGDKQALGVLPQQQQPQLQRHDDPYADEDMDDRDVELDIDEDGIFTCEEVNALTSAMWKAEGLTRVPRGSRHYRQAPPQQRTSAAAVDPLLPGALAASTTTPGGGSVADVTLQPLRNTTGEDGGRRGLGGDMRGLPSSFSNAPLFASTTTAATGLPSTSSTQPTSQALHRHHNDVDRQLCGNSNNGGRRMAEGGGGSVGGEGSRSSSSVYEVLIQRVLAMDTASDIWSLGVLLYGMCADTVDAQQQQQHHRHHQTSASTPTSTLSPPHATEAGSSRVRAHEGVADTLPPAIPTCTCASRLAQRAFAALLGDLYDLAVTGVPSGGPGNNGWSCDGGAGLRSVGGDEGDGVDVEPPDEAADDRLRWPRSCALEDEVMQVIGEAGYTHALASVLASMLSPVAARRPSAGDIVNQLRLVTTGAPATLASDIMRGGGGGLADADREYSVARQSPPPRTRHSGGASDATSSVMLHEQTARMALRQR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170.....----.1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280....-..1290......1300......1310......1320......1330.......1340......1350.--.......1360-----.....-.-1370......----1380....-.--.1390----........1400......1410......1420......1430----........1440......1450......1460......1470......1480......1490----..-------......-----1500--------------------------.---------------.......1510......1520-........1530-----.........1540......1550......1560......1570......1580......1590......1600......1610....---..1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGTS
R
V
HSTSGTAG
A
R
WNSISLG
P
R
SIAGSTRGPH
G
L
Q
C
R
R
G
F
R
V
L
H
F
L
L
A
C
A
I
A
L
H
A
V
T
A
P
L
S
T
C
Y
A
Y
I
R
HAAAPPSITAETPAAPSLIRPNGLPPAAPAA
P
W
R
T
LNESLLPY
P
V
F
Y
P
A
I
A
L
LNN
S
I
L
L
L
GGCATATCATPVGASG
T
R
V
A
ASRHRASAATSVT
S
P
Y
H
E
R
L
L
S
L
NVDKGN
I
T
TLPQLTLPSGLGFAG
R
Y
A
A
V
T
LTD
S
V
Y
V
A
R
SCTMSTQS
P
A
E
V
A
S
M
T
A
E
E
L
Q
A
M
Q
A
AYA
P
V
V
A
FYPEGTAHASTRVGGPDPPP
A
V
N
L
T
Y
F
KVPA
D
R
V
R
VNA
S
C
T
A
L
ATE
N
K
L
L
I
I
G
G
F
L
LSG
K
R
V
T
A
SVD
S
F
N
V
V
T
R
KYDA
D
V
A
F
L
TAPVLQPSVATSTG
F
A
A
V
AGG
W
T
YEADTTA
S
A
T
R
E
A
R
A
L
Q
E
E
S
R
V
RRS
S
R
V
AVSG
E
P
L
H
L
V
Q
E
LATPPGKSSASPRSDTPSSPPSRSVPSPA
P
L
Q
P
V
A
R
Y
L
F
D
L
LFFE
P
D
RVRG
C
S
RAVPRG
A
L
QIG
G
S
I
C
VSPVDSSTL
P
R
T
A
V
E
D
ILLSPNG
C
H
V
A
V
FG
G
Q
V
V
L
V
DHNLG
H
I
A
A
L
D
I
R
A
R
L
A
Q
A
F
A
ARA
P
L
V
LRPPP
A
V
T
L
L
RTAKPNAAARTFAGTESAASRDAQASSRHNDHAG
S
T
A
V
F
ASSGSSSAAPMTSSTSSSSSATASSSSSSAPL
P
E
Y
R
Y
SWMQ
P
T
L
ISLPYARRPAPAAAPDPP
V
M
A
D
T
I
L
L
Y
Y
ALG
G
E
D
V
W
S
Q
V
V
TAAGD
S
A
A
A
DLLDPSGRQHVVPQLHGDPS
T
L
RATGKG
T
E
A
V
V
RREP
T
L
R
W
A
Q
RELPDVRYDRDRP
E
L
L
A
V
TMPTPLWP
D
A
L
T
L
QTNSE
G
I
I
H
L
A
F
RDLN
Y
T
RYCRWNRLVDNDDD
N
V
V
C
A
V
R
LSSRRDCVGNTAGTLDSAYDGSPN
A
T
I
L
F
SASGST
T
P
V
Y
V
C
F
S
Y
VVRPTLW
P
T
C
R
I
R
Q
S
F
S
ILNPMM
P
L
R
I
LDNSHTTSAPTPTPRPSPTRDPADKTTSSP
L
F
M
L
A
V
G
V
S
I
V
T
L
L
V
A
L
L
L
A
A
R
L
Q
HVPED
G
L
L
V
M
S
L
L
DRGDGAGDQHASPGIRGRSCGGAARHNG
Q
G
R
R
K
R
L
LRGSGEPNKAADVEDDDEPG
L
Y
P
I
S
T
Y
A
E
F
L
Q
V
VGSAQEDS
E
A
R
M
L
A
T
A
V
D
V
L
R
L
H
Q
H
R
Y
R
V
L
S
R
IGQG
P
H
S
L
C
F
L
A
L
RKAPPPPP
L
R
V
Q
Q
Q
R
VRGAGAGMN
R
R
V
R
M
LDGDAS
P
V
V
R
S
SLFTRPPPSFPAASATLSPGVPTTA
T
S
S
L
W
AARHDQS
T
A
V
V
V
K
Y
TQCP
D
D
A
T
R
A
L
I
T
R
L
C
E
R
L
R
D
L
Q
A
D
A
V
T
E
A
LGAT
G
V
Y
R
Q
HRNSAPSRRPHRRYRPSDTSTTVSSAAA----LRPLDVST
Q
L
T
C
G
I
A
R
E
V
A
SGGRSSRG
G
A
A
A
Q
A
L
QTDAEDATAPPTSRRDS
S
A
I
I
V
T
TASRAGCQPLPPLSSAANE
A
R
V
IDGDDDDN
S
C
A
W
L
D
A
H
E
V
N
V
V
L
S
L
F
L
LL
P
E
-
D
L
F
V
S
Y
E
V
S
V
L
Q
QQNSNSSSQ
H
A
HVDRSGRLT
P
L
S
V
S
Q
A
A
V
EWN-RRHVWPGANAEPA
K
A
S
H
H
R
Q
--
R
--HRCT
P
M
L
S
A
GQ-----SLPEQ-S-TPR
V
C
W
A
A
CV----NPLQPSTL-R--
P
W
S
------
L
C
L
V
MPYERSG
D
L
A
D
F
I
L
R
C
Q
Q
V
Q
LLPADVTGAKD
T
K
RTG------LSSRTSASPACV
P
P
V
H
H
C
W
T
E
S
L
L
C
S
I
L
F
Q
V
C
T
G
L
Q
L
LHAQSPP
I
L
HGNIKQ
T
N
V
L
L
REP------AS-------
F
S
V
A
R
R
-----
R
V
----------------------------
V
---------------
V
AGT
P
A
A
L
A
G
M
KMGVSSGR---GGLEDANGD--------
L
D
M
A
A
A
T
MRVPG
A
Q
Q
AREGEGGWRD
R
R
L
EA
G
I
A
A
AARP
L
S
A
H
A
S
F
W
R
A
S
S
L
V
A
A
A
T
A
V
W
QAG
S
P
V
L
R
SSLSIGS
P
P
S
L
F
RAGATASS---STAAFSHDAPQEGQPQLQPHEDEQLW
P
P
E
R
A
R
H
L
L
STH
T
Y
L
P
I
S
LTDGG
M
S
W
W
L
T
V
QL
P
L
R
L
R
GCFGR
T
T
R
S
T
L
R
QA
P
A
G
L
C
W
L
RRLDPPPSSPPPITTKSSVLP
S
E
D
C
I
A
A
L
A
D
F
L
F
T
F
IDV
P
T
H
V
A
P
E
L
L
W
G
R
LCTLSQSDHGDEGGAAAGLAVPGSSLTQ
S
S
S
S
L
H
S
I
R
N
R
R
E
Q
H
V
A
S
SRRDGRRRGDGDS
L
T
H
R
R
C
G
D
V
AREPAASPAVGS
A
N
L
L
R
ATASDELGANVTGD
K
Q
A
L
GVLPQQQQPQLQRHDDPYADEDMDDRD
V
E
L
D
IDEDG
I
F
T
C
E
E
V
N
A
L
T
S
A
M
W
KAEGLTRVPRGSRHYRQAP
P
Q
QRTSAAAVDPLLPGALAASTTTPGGG
S
V
A
D
V
T
L
QPLRNTTGEDGGRRGLGGDMRGLPSSFSNA
P
L
F
ASTTTAATGLPSTSSTQ
P
T
S
Q
A
L
H
R
HHN
D
V
D
R
Q
LCGNSNNGGRRMAEGGGGSVGGEGSRSS
S
S
V
Y
E
V
L
I
Q
R
V
L
AMD
T
A
S
D
I
W
S
L
G
V
L
L
Y
G
MCADTV
D
A
Q
Q
Q
Q
Q
H
H
R
HHQTSASTPTSTLSPPHATEAGSSR
V
R
AHEGVADTLPPAIP
T
C
T
C
A
S
R
L
A
Q
R
A
F
A
A
L
L
G
D
L
Y
D
L
AVTGVPSGGPGNNGWSCDGGAGLRSVGGDEGDGVDVEPPDEAADDRLRWPRSCA
L
E
D
E
V
M
Q
V
I
GEAG
Y
T
H
A
L
A
S
V
L
A
S
M
L
S
P
V
A
ARRP
S
A
G
D
I
V
N
Q
L
R
L
V
TTGA
P
A
T
L
A
S
D
I
M
RGGGGGLADADREYSVARQSPPPRTRHSGGASDAT
S
S
V
M
L
H
E
Q
T
A
R
M
A
LRQR
45
Fugue
61.31
14%
19
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
LDLG
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
--
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
-------------
F
G
-
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
K
K
L
N
--
K
--
K
R
L
K
K
R
K
G
Y
Q
G
-----
A
M
V
E
K
-
K
-
I
L
A
K
V
H
S
R
F
I
----
V
S
L
A
Y
A
F
E
-
T
--
K
T
D
------
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
--------------------------------------
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
--
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
------
G
N
-------
V
R
I
S
D
L
-----
G
L
----------------------------
A
---------------
V
E
L
K
A
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
---
M
A
P
E
L
L
L
G
E
EYDF
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
-
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
---
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
---
S
W
R
Q
L
E
---
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
G
A
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
54.82
14%
1
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
-
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
--
G
--
V
L
L
T
E
K
L
K
P
V
D
-----
Y
E
Y
R
E
-
E
-
V
H
W
A
T
H
Q
L
R
L
----
G
R
G
S
F
G
E
V
-
H
--
R
M
E
D
KQTG
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
A
E
E
L
M
A
C
A
G
L
T
--
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
GS
H
A
A
L
C
D
-------
F
G
H
A
V
C
------
L
----------------------------
Q
---------------
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
----------
C
D
A
K
--------
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
F
F
R
G
P
L
C
L
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
C
A
-
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
---
S
P
W
R
G
E
Y
K
E
P
R
H
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
47.54
13%
20
- C1 -
-
1KOB
1
?
A:
[23-374]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
-
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
--
Y
--
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
-
A
-
T
G
R
V
F
V
A
K
F
I
N
T
PY
P
L
D
K
Y
T
V
K
-
N
--
E
I
S
------
I
M
N
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
-------------------
I
A
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
--
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
------
K
A
SSVKIID
F
G
L
A
T
K
LNPD
E
I
V
----------------------------
K
---------------
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
R
E
P
V
---
G
F
Y
T
D
M
-----------
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
---
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
-
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
SRI
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
46.98
13%
-68
- C1 -
-
5HHW
2
?
A:
[27-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
--
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
--
L
--
R
E
R
I
E
F
L
N
E
A
S
-----
V
M
K
G
F
-
T
-
C
H
H
V
V
R
----------
L
L
G
V
V
S
-
K
--
G
Q
P
------
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
--------------------------------
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
--
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
-
G
D
-------
F
G
M
T
R
D
-----
I
Y
----------------------------
E
TDYYRKGGK------
G
L
L
P
V
R
W
M
A
-----
P
E
S
L
K
---
D
G
V
F
T
T
S
S
D
--------
M
W
S
F
G
V
V
L
W
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
46.57
21%
-79
* C1 *
-
4XBR
1
INKA1_HUMAN
A:
[103-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
S
T
G
I
V
C
I
A
T
V
-------
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
--
Q
---
R
R
E
L
L
F
N
E
V
V
-----
I
M
R
D
Y
-
Q
-
H
E
N
V
V
E
----------
M
Y
N
S
Y
L
-
V
--
G
D
E
------
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-------------------------------------------
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
--
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
-
S
D
-------
F
G
F
C
A
Q
-----
V
S
----------------------------
K
EVPRRKS--------
L
V
G
T
P
Y
W
M
A
-----
P
E
L
I
S
---
R
L
P
Y
G
P
E
V
D
--------
I
W
S
L
G
I
M
V
I
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
43.88
15%
-11
- C1 -
-
2PSQ
-
B:
[89-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D---
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
--
E
--
K
D
L
S
D
L
V
S
E
M
E
-----
M
M
K
M
I
G
K
-
H
K
N
I
I
N
----------
L
L
G
A
C
T
-
Q
--
D
G
P
------
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
-------------------------------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
--
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
-
A
D
-------
F
G
L
A
R
D
-----
I
N
----------------------------
N
IDYYKKTTN------
G
R
L
P
V
K
W
M
A
-----
P
E
A
L
F
---
D
R
V
Y
T
H
Q
S
D
--------
V
W
S
F
G
V
L
M
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
43.50
40%
-280
- C2 -
-
4M69
1
RIPK3_MOUSE
A:
[109-165]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
C
P
R
P
----
W
--
P
L
L
C
R
L
L
Q
E
V
V
L
G
M
C
Y
L
H
S
L
D
P
P
L
L
H
R
D
L
K
P
S
N
I
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
42.93
43%
-274
- C2 -
-
4C57
1
GAK_HUMAN
A:
[139-170]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
F
Y
Q
T
C
R
A
V
Q
H
M
H
R
Q
K
P
P
I
I
H
R
D
L
K
V
E
N
L
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
42.64
41%
-338
* C2 *
-
5TF9
2
WNK1_HUMAN
A:
[126-165]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
41.39
19%
-54
- C1 -
-
4LQQ
1
CBK1_YEAST
A:
[110-379]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
-------
K
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
--
Y
KK--------------------
S
-
D
-
S
P
W
V
V
S
----------
L
Y
Y
S
F
Q
-
D
--
A
Q
Y
------
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
Q
------------------------------------------
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
--
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
-
S
D
-------
F
G
L
S
T
G
-----
F
H
K
T
H
D
S
N
YL
T
M
S
N
RQQ
I
Q
T
W
R
KSRRLMAY
S
---------------
T
V
G
T
P
D
Y
I
A
-----
P
E
I
F
L
---
Y
Q
G
Y
G
Q
E
C
D
--------
W
W
S
L
G
A
I
M
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
41.05
41%
-354
- C2 -
-
4PWN
-
A:
[121-165]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
41.04
16%
-41
- C1 -
-
4ASE
1
A:
[72-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
-
F
G
-
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
--
H
--
S
E
H
R
A
L
M
S
E
L
K
-----
I
L
I
H
I
-
G
H
H
L
N
V
V
N
----------
L
L
G
A
C
T
K
P
--
G
G
P
------
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
-
V
P
-----
Y
---------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
--
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
-
C
D
-------
F
G
L
A
R
D
-----
I
Y
----------------------------
K
DPD
Y
V
R
K
GD------
A
R
L
P
L
K
W
M
A
-----
P
E
T
I
F
---
D
R
V
Y
T
I
Q
S
D
--------
V
W
S
F
G
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
41.02
41%
-336
- C2 -
-
5O1V
4
WNK3_HUMAN
A:
[127-157]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
40.64
41%
-324
- C2 -
-
5O2B
1
WNK3_HUMAN
A:
[127-165]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
40.63
25%
-79
- C1 -
-
4G3F
1
A:
[66-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
R
G
S
F
G
E
V
H
R
M
K
D
-------
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
--
R
--------
V
E
E
L
V
-----
A
C
A
G
L
-
S
-
S
P
R
I
V
P
----------
L
Y
G
A
V
R
-
E
--
G
P
W
------
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
G
------------------------------------------
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
--
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
GS
R
A
A
L
C
D
-------
F
G
H
A
L
C
-----
L
------------------------------DY-------------
I
P
G
T
E
T
H
M
A
-----
P
E
V
V
M
---
G
K
P
C
D
A
K
V
D
--------
I
W
S
S
C
C
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
40.49
18%
-23
- C1 -
-
5TE0
8
AAK1_HUMAN
A:
[27-227]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
G
G
F
A
I
V
F
L
V
R
--------
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
-----
H
D
L
Q
V
C
K
R
E
I
Q
-----
I
M
R
D
L
-
S
G
H
K
N
I
V
G
----------
Y
I
D
S
S
I
-
N
N
V
V
W
E
------
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
Q
----------------------------------------
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
H
Y
V
L
-
C
D
-------
F
G
S
A
T
N
-----
K
F
----------------------------
Q
NPQTEG
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
-----
P
E
M
V
N
LYS
G
K
I
I
T
T
K
A
D
--------
I
W
A
L
G
C
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
40.49
23%
-70
- C1 -
-
4IDV
1
M3K14_HUMAN
A:
[82-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
R
G
S
F
G
E
V
H
R
M
E
D
-------
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
--
R
--------
A
E
E
L
M
-----
A
C
A
G
L
-
T
-
S
P
R
I
V
P
----------
L
Y
G
A
V
R
-
E
--
G
P
W
------
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
------------------------------------------
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
--
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
GS
H
A
A
L
C
D
-------
F
G
H
A
V
C
-----
L
Q
----------------------------
P
DGLGKSLLTGD
Y
---
I
P
G
T
E
T
H
M
A
-----
P
E
V
V
L
---
G
R
S
C
D
A
K
V
D
--------
V
W
S
S
C
C
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
40.44
19%
-58
- C1 -
-
4LQS
1
CBK1_YEAST
A:
[110-378]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
-------
K
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
YK
K
----------------------
S
-
D
-
S
P
W
V
V
S
----------
L
Y
Y
S
F
Q
-
D
--
A
Q
Y
------
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
Q
------------------------------------------
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
--
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
-
S
D
-------
F
G
L
S
T
G
-----
F
H
K
T
H
D
S
N
YNRQQ
I
Q
T
W
R
KSRRLMAY----
S
---------------
T
V
G
T
P
D
Y
I
A
-----
P
E
I
F
L
---
Y
Q
G
Y
G
Q
E
C
D
--------
W
W
S
L
G
A
I
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
39.03
41%
-320
- C2 -
-
3FPQ
-
WNK1_RAT
A:
[137-167]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
39.00
41%
-327
- C2 -
-
5O21
2
WNK3_HUMAN
A:
[127-157]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------