@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_09_0270: (2018-03-08 )
MGTSGFSRLRSLTPTPYPGTQGSPYRRHRFVGVNLPGAPPPSIDFSSIQRTVKEVYEVHEKLSEGTYGEVFKGVDKRTGAAVALKRIKMLSTHQGFPQTSLREVIALRHIQNQRERLEERLRNDAHHRGAVAITDPLAEVSQLCDVLLYDRQQRDIVLVFAYATASLAGLCRRQFAFTPSEMALLMKKLLIAVRKLHEMRIIHRDIKSDNVLVTSEGEVQLTDFGLCSIAAPGSSRSGTHVWRTPSVITLAYRPPEMLLGSTAYDEKVDVWSLGCLLAQMFLLEPPFYRHRAQAQQQQQRAPERSAATELEQLSRITEILGPLPPVSVYHPDSCQHMRVLEQLEVQGRLAEAGRAAQPANWGRLQTIFEPSFLYQQFHGFRGWFEAELGRSRHQPHRRPTQACMDVLCAALQLDPQQRPTAAELLRMPYFTTLDDAPLLGSYQRVLPVTPEREAEVRRGFMTKVQRCGDSHTQRRPHQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......---150.......160.......170..-..-...180.......190.......200.......210.......220.....-..230....---------...240.......250.......260.......270.......280.......290.......300.......310.......320........330.......340.......350.......360.......370.......380.........390.......400.......410.......420.......430.......440.......450.......460.......470......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGT
S
G
F
S
R
L
R
SLTPTPYPGTQGSPY
R
R
H
R
F
V
G
VNLPGAPPPSI
D
F
S
S
I
Q
R
T
V
K
E
V
Y
E
V
H
E
K
LSEGT
Y
G
E
V
F
KGVDKRT
G
A
A
V
A
L
K
R
I
K
M
L
S
THQGF
P
Q
T
S
L
R
E
V
I
A
L
R
H
I
Q
N
Q
R
E
R
L
E
E
R
L
R
NDAHHRG
A
V
A
IT
D
P
L
A
E
V
S
Q
L
C
D
V
L
L
Y---DRQQR
D
I
V
L
V
F
A
Y
A
T
A
S
L
A
G
L
C
R
R
Q-FA-F
T
P
S
E
M
A
L
L
M
K
K
L
L
I
A
V
R
K
L
H
E
M
R
I
I
H
R
DIKSD
N
V
L
V
TSEG
E
V
Q
L
T
D
F
G
L
C
-
S
IAAPGSSR---------SG
T
H
V
WRTP
S
V
I
T
L
AYR
P
P
E
M
LLGSTAYDEKV
D
V
W
S
L
G
C
L
L
A
Q
M
F
LLEP
P
F
Y
R
H
R
A
Q
A
Q
Q
Q
Q
Q
RAPE
R
S
A
A
T
E
L
E
Q
L
S
R
I
T
E
I
LG-PLPPVSVYHPDS
C
Q
H
M
R
V
L
E
Q
L
E
VQ
G
R
L
A
EAGRAAQPANWG
R
L
Q
T
IF
E
P
S
F
L
Y
Q
Q
F
H
GF--
R
G
W
F
E
A
E
LGRSRHQPHRR
P
T
Q
A
C
M
D
V
L
C
A
A
LQLDPQQR
P
T
A
A
E
L
LRMPYFTTLDDAPLLGS
Y
Q
RVLPVTP
E
R
E
A
E
V
R
R
G
F
M
T
K
V
Q
R
CGDSHTQRRPHQ
18
PsiBlast_PDB
84.19
28%
-80
- C1 -
-
3NIZ
1
?
A:
[21-308]
-----------------------------------------------------
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
Q
-
G
R
I
V
A
L
K
R
I
R
------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
---------------
H
H
P
N
I
V
S
L
I
D
V
I
H
--
S
E
R
C
L
T
L
V
F
---
E
F
M
E
K
D
L
K
K
V
----------
L
D
E
N
K
-
T
G
-
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
--
V
R
------------
H
-----
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
G
K
P
L
F
-----------------
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
----------------------------------
T
P
N
P
R
E
W
P
Q
V
Q
E
L
--
P
L
W
K
Q
R
T
F
Q
V
F
EK
K
P
W
S
S
I
I
P
G
F
---------
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
--------------------------------------------
19
PsiBlast_PDB
77.74
28%
-86
- C1 -
-
2QKR
-
?
A:
[21-308]
-----------------------------------------------------
E
K
Y
--
L
E
K
V
G
E
G
---
V
V
Y
K
A
K
D
S
Q
--
R
I
V
A
L
K
R
I
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
---------------
H
H
P
N
I
V
S
L
I
D
V
I
H
--
S
E
-
C
L
T
L
V
F
---
E
F
M
E
K
D
L
K
K
V
----------
L
D
E
N
K
-
T
G
-
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
-
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
--
V
R
-------------------
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
G
K
P
L
F
-----------------
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
----------------------------------
T
P
N
P
R
E
W
P
Q
V
Q
E
L
--
P
L
W
K
Q
R
T
F
Q
V
F
E
K
K
P
W
S
S
I
I
P
G
F
---------
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
--------------------------------------------
22
HHSearch
77.13
25%
-57
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[4-311]
---------------------------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---------------
H
D
N
----------
I
I
A
I
K
D
I
L
R
P
TVP
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
-
Q
P
-
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
-
R
G
L
C
T
S
P
A
E
---------
H
--
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
-----------------
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
-
T
P
S
-
P
A
V
I
Q
A
--
V
G
A
E
R
V
R
-
A
Y
-----------------
I
Q
S
L
P
P
R
--------
Q
P
-----
V
P
W
E
--
T
-------
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
-------------------------------------
45
HHSearch
75.24
30%
-65
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-300]
--------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
I
---------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---------------
H
----------
P
N
I
I
G
L
L
D
A
F
G
H
------
K
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
N
S
L
V
-
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
N
G
V
L
K
L
A
D
F
G
L
A
-
K
S
F
G
S
P
N
---------------
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
P
-----------------
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
-
T
P
T
-
E
E
Q
W
P
D
M
--
C
S
L
P
D
Y
V
T
F
------------------
K
S
F
P
G
I
-----------
P
L
--
H
H
I
F
------------
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
-------------------------------------------
8
PsiBlast_PDB
71.39
31%
-68
- C1 -
-
3MIA
1
CDK9_HUMAN
A:
[19-273]
-------------------------------------------------------
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
---------------
H
E
N
V
V
N
L
I
-------
E
I
C
R
T
---------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
-
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---------
P
N
R
Y
T
N
R
---
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-----------------
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
-
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.67
31%
-64
- C1 -
-
4IMY
1
CDK9_HUMAN
A:
[21-275]
-------------------------------------------------------
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
----------------------
V
V
N
L
I
E
I
C
R
T
---------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
-
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---------
P
N
R
Y
T
N
R
---
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-----------------
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
-
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.51
31%
-70
- C1 -
-
4BCI
1
CDK9_HUMAN
A:
[20-274]
-------------------------------------------------------
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
---------------
H
E
N
V
V
N
L
I
-------
E
I
C
R
T
----------
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
-
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
-------------
P
N
R
Y
T
N
R
---
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-----------------
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
-
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
70.46
32%
-63
- C1 -
-
4CXA
1
CDK12_HUMAN
A:
[15-247]
-------------------------------------------------------
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---------------
H
R
S
V
V
N
M
K
E
I
V
T
D
K
Q
-----
L
D
F
---
K
K
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
-
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
-
R
L
Y
N
S
E
E
-
R
---------
P
Y
T
N
-----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
-----------------
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.36
31%
-67
- C1 -
-
4BCJ
1
CDK9_HUMAN
A:
[20-274]
-------------------------------------------------------
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
---------------
H
E
N
V
V
N
L
I
-------
E
I
C
R
T
K
--------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
-
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
-------------
P
N
R
Y
T
N
R
---
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-----------------
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
-
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.02
32%
-59
- C1 -
-
4NST
3
CDK12_HUMAN
A:
[15-247]
-------------------------------------------------------
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---------------
H
R
S
V
V
N
M
K
E
I
V
T
D
K
Q
---
D
-----------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
-
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
-
R
L
Y
N
S
E
E
S
R
---------
P
Y
T
N
-----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
-----------------
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.99
32%
-60
- C1 -
-
4UN0
-
CDK12_HUMAN
C:
[727-961]
-------------------------------------------------------
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---------------
H
R
S
V
V
N
M
K
E
I
V
T
D
K
-------------
K
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
-
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
-
R
L
Y
N
S
E
E
S
R
---------
P
Y
T
N
-----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
-----------------
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.90
31%
-58
- C1 -
-
4OGR
1
CDK9_HUMAN
A:
[21-275]
-------------------------------------------------------
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
----------------------
V
V
N
L
I
E
I
C
R
T
---------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
-
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---------
P
N
R
Y
T
N
R
---
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-----------------
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
-
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
69.77
35%
-131
- C1 -
-
3OZ6
-
?
A:
[7-243]
---------------------------------------------------
V
L
R
K
Y
E
L
V
K
K
-------
I
V
W
K
S
I
D
R
R
T
G
E
V
V
A
V
K
K
I
F
D
--
Q
N
S
T
D
A
Q
R
T
F
R
E
I
M
I
L
T
E
L
S
--------------
G
H
----------
E
N
I
V
N
L
L
N
V
L
R
A
---
D
-
N
D
R
D
V
Y
L
V
F
D
Y
M
E
T
D
L
H
A
V
I
R
A
--
N
I
-
L
E
P
V
H
K
Q
Y
V
V
Y
Q
L
I
K
V
I
K
Y
L
H
S
G
G
L
L
H
R
D
M
K
P
S
N
I
L
L
N
A
E
C
H
V
K
V
A
D
F
G
L
S
-
R
S
F
V
N
I
R
R
V
T
N
NIPLSIN---------
Y
V
A
T
R
W
Y
R
A
P
E
I
L
L
G
S
T
K
Y
T
K
G
I
D
M
W
S
L
G
C
I
L
G
E
I
L
C
G
K
P
I
F
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.53
31%
-71
- C1 -
-
4EC8
-
CDK9_HUMAN
A:
[19-273]
-------------------------------------------------------
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
---------------
H
E
N
V
V
N
L
I
-------
E
I
C
R
T
K
--------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
-
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---------
P
N
R
Y
T
N
R
---
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-----------------
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
-
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.34
32%
-62
- C1 -
-
5EFQ
2
CDK13_HUMAN
A:
[3-245]
--------------------------------------------
I
D
W
G
K
R
C
V
D
K
-
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
H
Q
------------------
S
I
I
N
M
K
E
I
V
T
D
K
E
------------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
-
L
V
H
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
R
G
Q
I
K
L
A
D
F
G
L
A
-
R
L
Y
S
S
E
E
S
R
---------
P
Y
T
N
-----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
-----
Q
A
N
Q
------------
E
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
69.31
31%
-69
- C1 -
-
3MI9
-
CDK9_HUMAN
A:
[19-273]
-------------------------------------------------------
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
---------------
H
E
N
V
V
N
L
I
-------
E
I
C
R
T
---------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
-
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---------
P
N
R
Y
T
N
R
---
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-----------------
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
-
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.10
31%
-67
- C1 -
-
3MY1
3
CDK9_HUMAN
A:
[20-274]
-------------------------------------------------------
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
---------------
H
E
N
V
V
N
L
I
-------
E
I
C
R
T
K
--------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
-
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---------
P
N
R
Y
T
N
R
---
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-----------------
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
-
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
69.09
31%
-67
- C1 -
-
4BCG
2
CDK9_HUMAN
A:
[20-274]
-------------------------------------------------------
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
---------------
H
E
N
V
V
N
L
I
-------
E
I
C
R
T
---------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
-
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---------
P
N
R
Y
T
N
R
---
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-----------------
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
-
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.07
32%
-63
- C1 -
-
5ACB
1
CDK12_HUMAN
C:
[15-247]
-------------------------------------------------------
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---------------
H
R
S
V
V
N
M
K
E
I
V
T
D
K
Q
---
D
A
L
D
F
---
K
K
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
-
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
-
R
L
Y
N
S
E
E
S
R
---------
P
Y
T
N
-----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
-----------------
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.57
31%
-68
- C1 -
-
5L1Z
-
CDK9_HUMAN
A:
[19-273]
-------------------------------------------------------
Y
E
K
L
A
K
I
G
----
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
---------------
H
E
N
V
V
N
L
I
-------
E
I
C
R
T
---------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
-
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---------
P
N
R
Y
T
N
R
---
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-----------------
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
-
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
------------------------------------------------------------------------------------------------------------------------------------