@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_10_0880: (2018-03-08 )
MPPKKRKAVGSKRDATTATAAAAATAAKTRQRKTAGTKTAAASKKSTFKPAPKKRAAQLPCTSPAARMASKAATRKANIVKVTAASATKTKAAPAQKPSSSSSSHTSIRAESQQAANTPERGPTAEKIAVSSAERRKSSPSPQPPVAAEAAAATAPAPAARAHRKGATVKHPPRTDEELDDGGGIASSAAEEKTERTYRKDAHGNATAAPSTLTARTSTATRSSRPIVVVANNEDESEQEGNDGEDTIFFGSDVVDATRSDGDARQSQLDAPPPPHPSLAASTAAAVEQHLVTSPEVLPTHPLRLLHGGAGGRGGSSSSSSATLDLRGCTTPPPPLLQPAVRGTRKQTSDGNNNGADSPSRQSAESSPEALMADSESKPSSHRWQRQLLAGGTPATQRLREKDALQDGGHRQVGSPPAHAAETVKQLFTEPVRSISATSTPADDSPNGTLIMSHGSEEDGVEEADAPGLHRRQRQHHQHLPPPLDVSSIATHSDSESRWSVGRATEGPPLPPGSATAVTPPPLPSLVPRASSAGGAQLFHRHHRHNSGGVTDDLCRGTSTRLLSTQSSALKDDEASPSLQHKAMASAAQSIPAPAGRLRMGGNTSRQSSPSSSYVWLKRTAGGDAVEASHPAAPTSSAASTLFPAHPPFQQQQQQQQQQQWSSYACPHLSFTSPSSSQLSRLADIDVITEADADAEGGHAATTTTPQRLRLREPPVWRSPQITQLPKSLSVSPVSLRGDSRKGGVKGDAASSLPQPLSQTQPTAHSVSAASSSTGEATQTLAQASANAAGGLQASLHVVPSGPTAAPAVSRPSTQLITKAAATRPIASPGTMWICLDDDDCAGDDSDSEGEGVVGEAKTAAPLHNGSDVPLISVKMEIDAETDAVYTPPEHTAAAAASPSPSGSSHKGGVAVGGEEQTEAPGRLRSRRPSPSKADSGGAGVRVDQSNIPVLSPAQARRRPPAEKSHPIAEILSPTFRPRRRPPDTSADPSHSLGAGSATHQRLASWPASHCYINLDDDTEDEDAEESPPRQRARNAHALDGAVYSAQPMSSASVADVLPALLRASTVTGADARSQLSLPLIIDDDDDEGVPEVGSETHTKESGDQEVRCEGLSPKPPKPKRGTCVEGANEVVANEEDDDDLLKSPQKPHVKDFIFPNRLDPELRPSSPLYRSIHAYQQQYQQQQQRAQGKEEEEHAARHAAAAASPLQEGVNADCRHLPQSAAIPVVIGNTKGAPPDDVAAAGQAGHKRSRAKDAKTGAAAPALPDWGRPADTLLRDFFPTKFTKKSFMEAAKNVMSPMHFLEAGDFWAAFASAEFVGEGSFGLVWRCLTVDGDLVAVKSCPIILRTKANIEDSFSTIREIATMRFLSEMQVPYVLPLHSAFFVHAQEALPPLAQEALEWRQRLRKRAEEAALEVEVRLLARGGNRRASHTGAEEDIEDAPLTLEQQVAVQMERLTAAEGPEEQATRARLQSVRLPRFLSITHDDLTQSDATVFLVMELCDGDVEGISRSDGVAKGMVYCVSSALAAMHELGLLHLDLKPSNILFAYEHGPSQQRLQRFSASGPATDAVKFYLSDFGNCRLVGPDPMDEVQDSYGTFEYMDLRALRDAVCGRPTDAFSLGATLYELLYGRRLYPKCVDPRCRGEEDHSRECFVEAASQPVVLPTVGPPTTAAMVTPVTTIGLNTAAAGHARGPHANGGTGSTSGLICSGPALTPLQYLTLALLRKPWAERMTAEECRRYLVQTFHITQTEDSSP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......-----1300......1310......1320......1330........1340.....--.-1350.......1360......1370......1380......1390......1400......1410......1420......1430......1440.....-----.1450......1460......1470......1480...---------....1490......1500-.-------......---------1510----..-----.......1520........1530-.......1540......1550......1560......1570......1580...-.-------..1590..--....1600...------..-.1610......1620.....-.----------1630---------------......1640......1650.....-.1660......1670....------..1680......1690.......1700......1710....-----..1720...------...1730......1740......1750.---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MP
P
K
K
R
K
AVGSKRDAT
T
A
T
A
A
A
A
A
T
A
A
K
T
R
Q
RKTAGTKTAAASKKSTFKPAPKKRAAQLPCT
S
P
A
A
R
M
A
S
K
AATRKA
N
I
V
K
V
TAASATKTKAAPAQKPSSSSSSH
T
S
I
R
A
E
S
Q
QAANTPERGPT
A
E
K
IAV
S
S
A
E
RRKSSPSPQPPVAAEAAAATAPAP
A
A
R
AHRKGATVKHPPRTDEELDDGGGIA
S
S
A
A
E
E
K
T
E
R
T
Y
RKDAHGNATAAPS
T
L
T
A
RTSTATRSSR
P
I
V
V
V
ANNEDESEQEGNDGE
D
T
I
F
FGSDVVDATRSDGD
A
R
QSQLDAPPPPHP
S
L
A
A
S
T
A
A
A
V
E
Q
H
LVTSPEVLPTHP
L
R
L
LHGGAGGRGGSSSSS
S
A
T
L
D
LRGCTTPPPP
L
L
Q
P
A
VRGTRKQTSDGNNNGADSPSRQSAESSP
E
A
LMADSESKP
S
S
H
R
W
Q
R
Q
L
LAGGT
P
A
T
Q
R
L
R
E
K
DALQDGGHRQVGSPP
A
H
A
A
E
T
V
K
Q
L
F
T
E
P
V
R
S
ISATSTPADDSPN
G
T
L
I
M
SHGSEEDGVEEADAP
G
L
H
R
R
Q
R
Q
H
HQHLPPPL
D
V
S
S
IATHSDSESRWSVGRATEGPPLPPGSATAVTPPPL
P
S
LVPRASSA
G
G
A
Q
L
F
H
R
HHRHNSGGV
T
D
D
L
CRGTS
T
R
L
L
STQSSALKDDEASP
S
L
Q
H
K
A
M
A
S
A
A
Q
SIPAPAG
R
L
RMGGNTSRQSSPSS
S
Y
V
W
L
K
RTAGGDAVEASHPAAPTSSAASTLFPAHP
P
F
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
W
S
SYACPHLSFTSP
S
S
S
Q
L
S
R
LAD
I
D
V
I
TEADADAEGGHAATTT
T
P
Q
R
L
RLREPPVWRSP
Q
I
T
QLPKSLSV
S
P
V
S
LRGDSRKGGVKGD
A
A
SSLPQPLSQTQPTAHSVSAASSST
G
E
A
T
Q
T
L
A
Q
ASANAAGG
L
Q
A
S
L
H
V
VPSGPTAAPAVSRP
S
T
Q
L
I
T
K
AAATRPIASP
G
T
M
W
I
C
LDDDDCAGDDSDSEGEGVVGEAKTAAPLHNGSDV
P
L
I
S
V
K
M
E
I
DAETD
A
V
YTPPEHTAAAAASPSPSGSSHKG
G
V
A
VGGEEQTEAPGRLRSRRPSPSKADSGGA
G
V
R
VDQSNIPVLS
P
A
Q
ARRRPPAEKSH
P
I
A
E
I
LSPTFRPRRRPPDTSADPSHSLGAG
S
A
T
H
Q
R
L
A
SWPA
S
H
C
Y
I
NLDDDTEDEDAEESP
P
R
Q
R
ARNAHALDG
A
V
YSAQPMSS
A
S
V
A
D
V
L
P
A
L
L
R
A
STVTGADARSQLS
L
P
L
I
I
DDDDDEGVPEVGSETHTKESGDQ
E
V
R
CEGLSPKPPKPKRGTCVEGA
N
E
VVANEED
D
D
D
L
LKSPQKPH
V
K
DFIFPNRLDPELRPSS
P
L
Y
R
S
I
H
A
Y
Q
Q
Q
Y
Q
Q
Q
Q
Q
RAQGK
E
E
E
E
H
A
A
R
H
A
A
A
A
A
S
P
L
Q
EGV
N
A
D
C
R
HLPQSAAI
P
V
V
IGNTKGA
P
P
D
D
V
A
AAGQAGHKRSRAKDAKTGAAAPALPDWGR
P
A
D
T
L
L
R
D
FFPTKF
T
K
K
S
F
M
E
A
A
K
N
V
M
S
P
M
-----
H
F
LEAG
D
F
W
A
A
F
AS
A
E
F
VGEGSF
G
L
V
W
R
C
L
T-V-DG
D
L
V
A
VKSC
P
I
I
L
R
T
K--A-NI
E
-
D
S
F
S
T
I
R
E
I
A
T
M
R
F
L
S
EMQV
P
Y
V
L
PLH
S
A
F
F
V
H
A
Q
EAL
P
P
L
A
Q
E
A
L
E
W
R
Q
R
L
R
K
R
A
E
E
A
A
L
E
V
E
V
R
L
L
ARGGNRRASHTGAEEDIEDAP
L
T
L
E
Q
Q
V
-----
A
V
Q
M
E
R
L
TAAEG
P
E
E
Q
A
T
R
A
R
L
Q
SVRLP
R
F
L
S
-ITHDD---------LTQSD
A
T
V
F
L
V
M
ELCD-G-D-------VEGISR---------S-------D
G
-----
V
A
K
G
M
V
Y
C
--
V
S
S
A
L
A
A
M
H
EL
G
--
L
L
H
L
DLKPS
N
I
L
F
A
YEHGP
S
Q
Q
R
L
Q
R
FSASGPA
T
D
A
V
K
F
Y
L
S
DFGN
C
R
LVGPD
P
-
M
-------
D
E
V
Q
D
S
YG--TF
E
Y
M
D
L
R
A
L
R
------
D
A
-VCGRPT
D
A
F
S
L
G
A
T
L
Y
E
L
L
Y-G----------RRLY---------------PKCVDPRCRGEEDH
S
R
E
C
F
V
E
AASQ-
P
V
V
L
PTVGPPTT
A
A
M
V
T
P
V
------
T
T
IGLNTAAAGHARG-PHANGGTGSTS
G
L
I
CSGPAL
T
P
L
Q
Y
-----
L
T
L
A
L
L
RKP------
W
A
E
RM
T
A
E
E
C
R
R
Y
L
V
Q
T
F
H
I
TQTEDSSP---
31
HHSearch
82.79
26%
-45
- C2 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[90-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
--------
Q
-
R
R
E
L
L
F
N
E
V
V
I
M
R
D
---
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------------------------------------------------------------------------------------------------------------------------
G
D
E
L
W
V
V
M
E
F
L
E
-
G
G
A
-------
L
T
D
I
V
T
H
T
R
M
-----
N
-------
E
E
-----
Q
I
A
A
V
C
L
A
--
V
L
Q
A
L
S
V
L
H
A
Q
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
--------------------
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
-
P
--------
R
R
K
S
L
V
G
--
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
-
G
----------
E
P
P
Y
---------------
F
N
E
P
P
L
K
-----------
A
M
K
M
I
R
D
-
N
--
L
P
P
R
----------------------------------------------
L
K
N
L
H
K
V
S
P
S
L
K
G
-----
F
L
D
R
L
L
V
R
D
------
P
A
Q
R
A
T
A
A
E
L
L
K
H
------------------
37
HHSearch
82.11
20%
-79
- C2 -
-
5TE0
10
AAK1_HUMAN
A:
[18-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
-
S
-
N
G
M
K
C
A
L
K
R
M
F
V
N
N
--------
E
H
-
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
--
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
----------------------------------------------------------------------------------------------------------------------
V
W
E
V
L
I
L
M
D
F
C
R
-
G
G
Q
-------
V
V
N
L
M
N
Q
R
L
QTGF--
T
-------
E
N
-----
E
V
L
Q
I
F
C
D
--
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
--------------------
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
-
Q
TEG
V
N
A
V
E
D
E
I
K
K
Y
T
--
T
L
S
Y
R
A
P
E
M
V
N
LYS---
G
K
-
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
-
F
----------
T
L
P
F
---------------
G
E
S
Q
V
---------------
A
I
C
D
G
-
N
F
T
I
P
D
--------------------------------------------------
N
S
R
Y
S
Q
D
M
H
C
-----
L
I
R
Y
M
L
E
P
D
------
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
------------
24
HHSearch
81.20
23%
-60
- C2 -
-
3C0G
1
CSKP_HUMAN
B:
[21-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
-
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
--
S
-
P
G
L
-
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
---
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
------------------------------------------------------------------------------------------------------------------------
D
G
M
L
Y
M
V
F
E
F
M
D
-
G
A
D
-------
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
-------
E
A
-----
V
A
S
H
Y
M
R
Q
--
I
L
E
A
L
R
Y
C
H
D
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
-----------------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
-
L
--------
V
A
G
G
R
V
G
--
T
P
H
F
M
A
P
E
V
V
K
------
R
E
-
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
----------
C
L
P
F
---------------
Y
G
T
K
E
R
-----------
L
F
E
G
I
I
K
G
-
K
Y
K
M
N
P
------------------------------------------------
R
Q
W
S
H
I
S
E
S
A
K
D
-----
L
V
R
R
M
L
M
L
D
------
P
A
E
R
I
T
V
Y
E
A
L
N
H
------------------
33
HHSearch
80.15
23%
-44
- C2 -
-
2Y7J
1
PHKG2_HUMAN
D:
[88-360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
-
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
SP
E
-
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
--
G
H
P
H
I
I
T
L
I
D
S
Y
E
------------------------------------------------------------------------------------------------------------------------
S
S
S
F
M
F
L
V
F
D
L
M
R
-
K
G
E
-------
L
F
D
Y
L
T
EKVAL----
S
-------
E
K
-----
E
T
R
S
I
M
R
S
--
L
L
E
A
V
S
F
L
H
A
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
--------------------
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
----------
K
L
R
E
L
C
G
--
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
-
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
----------
S
P
P
F
---------------
W
H
R
R
Q
I
----------
L
M
L
R
M
I
M
E
G
-
Q
Y
Q
F
S
S
------------------------------------------------
P
E
W
D
D
R
S
S
T
V
K
D
-----
L
I
S
R
L
L
Q
V
D
------
P
E
A
R
L
T
A
E
Q
A
L
Q
H
------------------
25
HHSearch
79.83
23%
-59
- C2 -
-
3C0I
1
CSKP_HUMAN
A:
[21-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
-
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
--
S
-
P
G
L
-
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
---
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
------------------------------------------------------------------------------------------------------------------------
D
G
M
L
Y
M
V
F
E
F
M
D
-
G
A
D
-------
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
-------
E
A
-----
V
A
S
H
Y
M
R
Q
--
I
L
E
A
L
R
Y
C
H
D
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
-----------------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
-
L
--------
V
A
G
G
R
V
G
--
T
P
H
F
M
A
P
E
V
V
K
------
R
E
-
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
----------
C
L
P
F
---------------
Y
G
T
K
E
R
-----------
L
F
E
G
I
I
K
G
-
K
Y
K
M
N
P
------------------------------------------------
R
Q
W
S
H
I
S
E
S
A
K
D
-----
L
V
R
R
M
L
M
L
D
------
P
A
E
R
I
T
V
Y
E
A
L
N
H
------------------
30
HHSearch
79.49
23%
-48
* C2 *
-
2Y7J
1
PHKG2_HUMAN
C:
[89-360]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
-
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
SP
E
-
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
--
G
H
P
H
I
I
T
L
I
D
S
Y
E
------------------------------------------------------------------------------------------------------------------------
S
S
S
F
M
F
L
V
F
D
L
M
R
-
K
G
E
-------
L
F
D
Y
L
T
EKVAL----
S
-------
E
K
-----
E
T
R
S
I
M
R
S
--
L
L
E
A
V
S
F
L
H
A
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
--------------------
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
----------
K
L
R
E
L
C
G
--
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
-
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
----------
S
P
P
F
---------------
W
H
R
R
Q
I
----------
L
M
L
R
M
I
M
E
G
-
Q
Y
Q
F
S
S
------------------------------------------------
P
E
W
D
D
R
S
S
T
V
K
D
-----
L
I
S
R
L
L
Q
V
D
------
P
E
A
R
L
T
A
E
Q
A
L
Q
H
------------------
32
HHSearch
77.24
18%
-84
- C2 -
-
5T18
1
A:
[7-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
-
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---------
M
-
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
---
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
------------------------------------------------------------------------------------------------------------------------
Q
R
P
I
F
I
I
T
E
Y
M
A
-
N
G
C
-------
L
L
N
Y
L
R
EF-------
Q
-------
T
Q
-----
Q
L
L
E
M
C
K
D
--
V
C
E
A
M
E
Y
L
E
S
K
Q
--
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
--------------------
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
-
Y
-------
T
S
S
V
G
S
K
F
--
P
V
R
W
S
P
P
E
V
L
M
------
Y
S
-
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
----------
K
M
P
Y
---------------
E
R
F
T
N
S
E
----------
T
A
E
H
I
A
-
Q
-
G
L
R
-
L
-
Y
------------------------------------------------
R
P
H
L
A
S
E
K
V
Y
T
-----
I
M
Y
S
C
W
H
E
K
------
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
------------
36
HHSearch
74.91
22%
-34
- C2 -
-
1TKI
-
TITIN_HUMAN
A:
[19-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
-
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
---------
T
-
D
Q
V
L
V
K
K
E
I
S
I
L
N
---
I
A
R
H
R
N
I
L
H
L
H
E
S
F
E
S
------------------------------------------------------------------------------------------------------------------------
M
E
E
L
V
M
I
F
E
F
I
S
-
G
L
D
-------
I
F
E
R
I
N
T
SA
F
E
L
---
N
-------
E
R
-----
E
I
V
S
Y
V
H
Q
--
V
C
E
A
L
Q
F
L
H
S
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
----------------
S
S
--
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
----------
N
F
R
L
L
F
T
--
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
-
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
----------
I
N
P
F
---------------
L
A
E
T
N
Q
Q
----------
I
I
E
N
I
M
N
A
-
E
Y
T
F
D
E
------------------------------------------------
E
A
F
K
E
I
S
I
E
A
M
D
-----
F
V
D
R
L
L
V
K
E
------
R
K
S
R
M
T
A
S
E
A
L
Q
H
------------------
28
HHSearch
72.96
23%
-22
- C2 -
-
4NIF
-
KS6A1_HUMAN
A:
[6-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
D
G
Y
V
V
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
-
T
N
M
E
Y
A
V
K
V
I
D
K
S
K
-------------
R
D
P
S
E
E
I
E
I
L
L
R
Y
--
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
------------------------------------------------------------------------------------------------------------------------
G
K
H
V
Y
L
V
T
E
L
M
R
-
G
G
E
-------
L
L
D
K
I
L
R
QKFF----
S
-------
E
R
-----
E
A
S
F
V
L
H
T
--
I
G
K
T
V
E
Y
L
H
S
Q
G
--
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
----------------
N
P
E
C
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
---------
G
L
L
M
T
P
C
Y
-----
F
V
A
P
E
V
L
K
------
R
Q
-
G
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
-
G
----------
Y
T
P
F
---------------
A
N
G
P
S
D
-------
T
P
E
E
I
L
T
R
I
G
S
G
-
K
F
T
L
S
G
------------------------------------------------
G
N
W
N
T
V
S
E
T
A
K
D
-----
L
V
S
K
M
L
H
V
D
------
P
H
Q
R
L
T
A
K
Q
V
L
Q
H
------------------
45
Fugue
72.25
15%
30
- C2 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
-
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
-
R
K
A
C
G
R
N
L
-
T
-
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
--
Q
-
L
V
T
-
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
--
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
K
N
T
F
R
Q
-
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
K
M
Y
A
C
K
-----
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
--
V
S
L
A
Y
---------
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
-
G
G
D
-------
L
K
F
H
I
Y
---------
H
-------
M
G
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
--------------
D
D
H
G
------
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
----------
T
I
K
G
R
V
G
--
T
V
G
Y
M
A
P
E
V
V
K
------
N
E
-
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
-
G
----------
Q
S
P
F
---------------
Q
Q
------
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
-
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
CKDPA
E
R
L
G
C
R
G
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
AIYCE
P
T
D
Q
D
F
Y
Q
K
------
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
DGS
35
HHSearch
71.68
20%
-27
- C2 -
-
2X0G
-
DAPK1_HUMAN
A:
[4-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
-
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
R
R
G
V
-
S
R
E
D
I
E
R
E
V
S
I
L
K
E
---
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
------------------------------------------------------------------------------------------------------------------------
K
T
D
V
I
L
I
L
E
L
V
A
-
G
G
E
-------
L
F
D
F
L
A
E
KESL----
T
-------
E
E
-----
E
A
T
E
F
L
K
Q
--
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
----------------
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
----------
E
F
K
N
I
F
G
--
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
-
G
----------
A
S
P
F
---------------
L
G
D
T
K
Q
----------
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
------------------------------------------------
E
Y
F
S
N
T
S
A
L
A
K
D
-----
F
I
R
R
L
L
V
K
D
------
P
K
K
R
M
T
I
Q
D
S
L
Q
H
------------------
40
HHSearch
71.30
24%
-83
- C2 -
-
1J1B
1
GSK3B_HUMAN
B:
[52-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
-
S
G
E
L
V
A
I
K
K
V
L
Q
D
-------------
K
R
F
K
N
R
E
L
Q
I
M
R
K
---
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
------------------------------------------------------------------------------------------------------------------
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
-
E
-
T
-------
V
Y
R
V
A
R
H
Y
S
R
A
KQTL
P
-------
V
I
-----
Y
V
K
L
Y
M
Y
Q
--
L
F
R
S
L
A
Y
I
H
S
F
G
--
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
-----------------
A
--
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
----------
P
N
V
S
Y
I
C
--
S
R
Y
Y
R
A
P
E
L
I
F
------
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
----------
Q
P
I
F
---------------
P
G
D
--------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
69.82
25%
-43
- C2 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
-
T
G
L
K
L
A
A
K
I
I
K
T
R
G
--------
M
K
-
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
---
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
------------------------------------------------------------------------------------------------------------------------
K
N
D
I
V
L
V
M
E
Y
V
D
-
G
G
E
-------
L
F
D
R
I
I
D
E
SYNL---
T
-------
E
L
-----
D
T
I
L
F
M
K
Q
--
I
C
E
G
I
R
H
M
H
Q
M
Y
--
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
----------------
A
K
--
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
----------
K
L
K
V
N
F
G
--
T
P
E
F
L
A
P
E
V
V
N
------
Y
D
-
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
-
G
----------
L
S
P
F
---------------
L
G
D
N
D
A
E
----------
T
L
N
N
I
L
A
C
-
R
W
D
L
E
D
------------------------------------------------
E
E
F
Q
D
I
S
E
E
A
K
E
-----
F
I
S
K
L
L
I
K
E
------
K
S
W
R
I
S
A
S
E
A
L
K
H
------------------
34
HHSearch
66.41
18%
-73
- C2 -
-
4Y95
4
?
A:
[6-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
-
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---------
M
-
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
---
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
------------------------------------------------------------------------------------------------------------------------
Q
R
P
I
F
I
I
T
E
Y
M
A
-
N
G
C
-------
L
L
N
Y
L
R
E
M
RHRF---
Q
-------
T
Q
-----
Q
L
L
E
M
C
K
D
--
V
C
E
A
M
E
Y
L
E
S
K
Q
--
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
--------------------
V
V
K
V
S
D
F
G
M
T
R
F
V
L
D
D
E
-
Y
-------
T
S
S
T
G
T
K
F
--
P
V
K
W
A
S
P
E
V
L
M
------
Y
S
-
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
----------
K
M
P
Y
---------------
E
R
F
T
N
S
E
----------
T
A
E
H
I
-
A
Q
-
G
L
R
L
P
R
--------------------------------------------------
P
H
L
A
S
E
R
V
Y
A
-----
I
M
Y
S
C
W
H
E
K
------
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
-----------
52
Fugue
62.45
16%
-17
- C2 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
-----
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
A
E
E
L
M
A
-
C
A
G
L
T
SPR
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
-
S
-------
L
G
Q
L
V
K
---------
E
-------
Q
G
CLP
E
D
R
A
L
Y
Y
L
G
Q
--
A
L
E
G
L
E
Y
L
H
S
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
-------------------
S
D
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
I
P
-----------------
G
--
T
E
T
H
M
A
P
E
V
V
L
------
G
R
-
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
----------
C
H
P
W
TQFFRGPL
C
L
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
------
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
-
P
R
H
P
------------------------------------------------------------------------
49
Fugue
59.33
15%
-34
- C2 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G
-------
N
K
V
A
V
-----
K
C
I
K
-----
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
-
Q
L
L
G
V
---------
I
V
--
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
-
S
-------
L
V
D
Y
L
R
---------
S
R
GRSVLG
G
D
-----
C
L
L
K
F
S
L
D
--
V
C
E
A
M
E
Y
L
E
G
N
N
--
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
--------------------
V
A
K
V
S
D
F
G
--------------------------LL
P
V
K
W
T
A
P
E
A
L
R
------
E
K
-
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
-
F
GRVPYPRIPL
K
D
V
V
---------------
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
-
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
------
E
H
I
K
T
H
E
L
------------------------------------------------------------------------------------
23
HHSearch
57.67
21%
-24
- C2 -
-
4G3F
1
A:
[124-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
N
I
F
M
E
L
L
E
-
G
G
S
-------
L
G
Q
L
I
K
Q
M
GCL----
P
-------
E
D
-----
R
A
L
Y
Y
L
G
Q
--
A
L
E
G
L
E
Y
L
H
T
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
-----------------
S
--
R
A
A
L
C
D
F
G
H
A
L
C
L
----------------
D
Y
I
P
G
--
T
E
T
H
M
A
P
E
V
V
M
------
G
K
-
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
----------
C
H
P
W
---------------
T
Q
Y
F
R
G
----------
P
L
C
L
K
I
A
S
E
-
P
P
P
I
R
E
-------------------------------------------------
I
P
P
S
C
A
P
L
T
A
Q
-----
A
I
Q
E
G
L
R
K
E
------
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
-----------
21
HHSearch
55.95
18%
-46
- C2 -
-
2PSQ
-
B:
[204-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
V
S
C
T
Y
Q
--
L
A
R
G
M
E
Y
L
A
S
Q
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
--------------------
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
-
Y
Y------
K
K
T
T
N
G
R
L
--
P
V
K
W
M
A
P
E
A
L
F
------
D
R
-
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
----------
G
S
P
Y
---------------
P
G
I
P
V
E
----------
E
L
F
-
K
L
L
K
E
-
G
H
R
-
M
D
-------------------------------------------------
K
P
A
N
C
T
N
E
L
Y
M
-----
M
M
R
D
C
W
H
A
V
------
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
--------
44
Fugue
54.00
15%
30
- C2 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
ETSSK
K
T
Y
M
A
K
F
V
K
V
K
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
H
R
N
I
L
H
L
H
E
---------
S
F
E
S
M
E
E
L
V
M
I
F
E
F
I
S
-
G
-
L
D
I
F
E
R
I
N
T
S
A
F
E
L
---------
N
-------
E
R
-----
E
I
V
S
Y
V
H
Q
--
V
C
E
A
L
Q
F
L
H
S
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
S
S
------------------
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
----------
D
N
F
R
L
L
F
T
--
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
-
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
----------
I
N
P
F
---------------
L
--------
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
-
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
------
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
-
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
-----
R
Y
Y
H
T
L
I
K
K
DLNMVV
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
----
38
HHSearch
51.78
20%
-44
- C2 -
-
4ASE
1
A:
[186-348]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Y
S
F
Q
--
V
A
K
G
M
E
F
L
A
S
R
K
--
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
--------------------
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
-------
V
R
K
G
D
A
R
L
--
P
L
K
W
M
A
P
E
T
I
F
------
D
R
-
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
----------
A
S
P
Y
---------------
P
G
V
K
I
D
----------
E
E
F
C
R
R
L
K
E
-
G
T
R
-
M
-------------------------------------------------
R
A
P
D
Y
T
T
P
E
M
Y
Q
-----
T
M
L
D
C
W
H
G
E
------
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
-----------