@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_11_0060: (2018-03-08 )
MAKEVLNNIQPCLPSGMPCMMQIVSTVAAIVECSIDPPSQQQNGKAQGEPKVLSAGQSSSLTPVPLKAKEALKLSLFAFHLLKKCCHMKNPESNEEAASNFDWLVKYLLDSVSIFPEAARSFFPWNGISFSRAFAANIESALALPPDQQGLPKWLWEDEGRNLRIQQGSEGRYRNEFIQQRLLGTGGFAPVYVCRKKIDGRLYAIKKIAMTEAQSEKVLREVQTLAALNHKNIVRYYDAWVEDGCDEDLREFVDTDAEDEEDEKMKHGGKMLSPQSRAVARASLSSDTDCTSSLYSSSVEKSSSADTSEEDHESGESCSDSGDARSDVKMHEPKGRRPSMNFQTLYIQMELCSARSLRHLIDESDSSDSGGIFSSANGEKVAVSILRQLLSVTAHTHRERIVHRDLKPENVLFEMESNHNSEAGTIRVADFGLARVMSGVKRITSVLDVDEVNTPTNLVSANYPTGNCGSVLYCAPEQEKGLEYDYKVDEFSIGMIAFEMWLAIAGKGFRERFTIMGEVWRTGKLPQWFARWNPTMADIIEKLLEPDPRRRTTCEAVLSTAELPGDPADLTSALDTVDRYGERIAGRIIQKIQRIGSEFRKPSRAFRDDAQFVGSSQCTDVVQAVQVIGMLHGAVPVALFDPTVAMNPKLAEMNVDCVVDSSGRSFAYSALPYFATASFLGMQENSAIGSFYQFYHRARSYVIFTTPLPHHGVFNECVLEPLLSLCHLLAFTETTEPMEVIVSHVHWLKTVFPAEIGTRSPPPALCHLRSEILTADQVGHAISSITESLCAAGLLLCDERDEYIKKFTMAVVDVINTFAKHMNTHLTLVMDPALQPSDLLVARKALETGIIFECRSTRGAVPLAFGCFLDNFTTNCTVVNPDISAFSVVVDVQHLLNVGKHVHVTWRENLLLDGVAAKRHDLYSLTQLPHVVEAAIQLWKGNIRACIRADTDARALARALKAKQIRWLLVDGKRIVAVSTNQQGKVSGHGGDIALDDLRQTVRSLSVKEKSTSSANIDVQFLSGKVETRTADKIVELFSTMMTPPPSTVVVVNTDVKRIHECLEQFNESAPDSPPETLAEPTLARWMKANAAASSVVPVYSLTEGKIVFFVNYKRFKVSGKKK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210-.------.---------......220......-.230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330-.......340.......350.......360.......370.......380---........390.......400.........410.......420.......430.......440.......450.......460.......470.......480----.........490.......500----.........-510--.......520.--.-.-.---.-.--..----------530.......540.......550.......560.......570.......580-.....------..590.......600.......610.--......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......--790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
K
E
V
L
N
NI
Q
P
CLPSG
M
P
C
M
M
Q
I
V
S
T
V
A
A
I
V
ECSIDPPSQQQNGKAQGEP
K
V
LSAGQSSSLTPVPL
K
A
K
E
A
L
K
L
S
L
F
A
F
H
L
L
K
K
C
CHMKNPES
N
E
E
A
AS
N
F
D
W
L
V
K
Y
L
L
D
S
V
SI
F
P
E
A
A
R
SFFPWNGI
S
F
S
R
A
F
A
A
N
I
E
S
ALALPPDQQGL
P
K
W
L
WEDEG
R
N
L
R
I
QQGSEG
R
Y
R
N
E
F
I
Q
Q
R
LLGTGG
F
A
P
V
Y
V
C
R
K
KIDG
R
L
Y
A
I
K
K
IAM
T
--
E
------
A
---------
Q
S
E
K
V
L
R
E
V
Q
T
L
A
AL-N
H
K
N
I
V
R
Y
Y
D
A
W
V
EDG
C
D
E
D
L
R
E
F
VDTDAED
E
E
D
E
K
M
K
HGGKMLSP
Q
S
R
A
V
A
RASLSSDTD
C
T
S
S
L
Y
S
S
S
VEKSSSADTSEEDHESGESCSDSGDARSDVKMHE-PKGRRPSMN
F
Q
T
L
Y
I
Q
M
ELC
S
A
R
S
L
R
H
L
IDESDSSDSGGIFSSANGE
K
V
----
A
V
S
I
L
R
Q
L
L
S
V
T
A
H
T
H
R
E
R
--
I
V
HRDLKPE
N
V
L
F
E
MESNHNSEA
G
T
I
R
V
A
D
F
G
L
A
R
V
M
S
G
V
K
R
I
T
S
V
LDVDEVNTPT
N
L
V
SANYPTGNCG
S
V
L
Y
CAPEQEK------GLEYDYKVDEF
S
I
G
M
I
A
F
E
M
------
W
L
A
I
AGK
G
F
-
R
E
R
--
F
T
I
M
G
E
V
WR-T--G-K-L---
P
-
Q
--
W
F
----------
A
RWNP
T
M
A
D
I
I
E
K
L
LEPDPRR
R
T
T
C
E
A
V
L
S
T
AELPG
D
P
A
D
L
T
S
A
L
D
T
V
D
R
Y
G
E
-
R
I
A
G
R
------
I
I
Q
K
I
Q
R
I
G
S
E
FR
K
P
S
R
A
F
R
D
D
A
Q
FV--G
S
S
Q
C
T
D
V
V
Q
A
V
Q
V
I
G
M
L
HGA
V
P
V
A
L
FDPTVAMNP
K
L
AE
M
N
V
D
C
V
VDSSGR
S
F
A
Y
S
A
L
P
Y
F
A
T
A
S
F
LGMQENS
A
I
G
S
F
Y
Q
F
Y
H
R
AR
S
Y
V
I
F
TTPLPHHG
V
F
N
E
C
V
L
E
P
L
L
S
L
C
H
L
L
A
FTETT
E
P
M
E
V
I
V
S
H
V
H
W
L
K
T
V
F
P
A
EIGTRSP
P
P
A
L
C
H
L
R
S
E
I
L
T
A
D
Q
V
G
H
A
I
S
S
I
T
E
S
L
--
C
A
A
G
L
LLCD
E
R
D
E
Y
I
K
K
F
T
M
A
V
V
D
V
I
N
T
F
A
K
HMNT
H
L
T
L
V
MDPALQ
P
S
D
L
L
V
A
R
K
A
LET
G
I
I
F
E
CRSTRGAV
P
L
A
F
G
C
F
LDNFTTN
C
T
V
VNPDI
S
A
F
S
V
V
V
D
V
Q
H
L
L
NVG
K
H
V
H
V
T
W
R
ENLLLD
G
V
AAK
R
H
D
L
Y
S
L
T
Q
L
P
H
V
V
E
A
A
I
Q
L
W
KG
N
I
R
A
C
I
RADT
D
A
R
A
L
A
R
A
L
K
AK
Q
I
R
W
L
L
VDG
K
R
I
V
A
V
STNQQGKVSGHGGDI
A
L
D
D
L
R
Q
T
V
R
SLSVKEKSTSSA
N
I
D
V
Q
F
LSGKVETR
T
A
D
K
I
V
E
L
F
S
T
MMTPPP
S
T
V
V
V
VNT
D
V
K
R
I
H
E
C
L
E
Q
F
NESAPDSP
P
E
T
LA
E
P
T
L
A
R
W
M
K
ANAAASS
V
V
P
V
Y
SLTE
G
K
I
V
F
F
V
N
Y
K
R
F
K
VSGKKK
42
HHSearch
75.78
35%
10
- C1 -
-
4G31
2
A:
[2-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
L
T
D
F
E
P
I
Q
C
L
G
R
G
--
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
--
N
------
R
E
L
-------
A
R
E
K
V
M
R
E
V
K
A
L
A
K
L
-
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
K
N
--------------------------------------------------------------------------------------------------
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
I
---
E
E
----
R
E
R
S
V
----
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
--
L
M
H
R
D
L
K
P
S
N
I
F
F
T
-------
M
D
D
V
V
K
V
G
D
F
G
L
V
----------------------------------
G
T
K
L
Y
M
S
P
E
Q
I
H
------
G
N
S
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
------
L
Y
P
F
S
T
Q
---
M
E
R
--
V
R
T
L
T
D
V
-
R
-
N
--
L
-
K
-
F
---
P
-
P
--
L
F
----------
T
Q
K
Y
P
C
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
74.98
33%
-5
- C1 -
-
4X7K
3
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Y
L
T
D
F
E
P
I
Q
C
L
G
R
G
G
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
--
N
------
R
E
L
-------
A
R
E
K
V
M
R
E
V
K
A
L
A
K
L
-
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
A
P
P
-------------------------------------------------------------------------------------------------
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
I
---
E
E
----
R
E
R
S
V
----
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
--
L
M
H
R
N
L
K
P
S
N
I
F
F
T
-------
M
D
D
V
V
K
V
G
D
F
G
L
V
T
----------------------------------
T
K
L
Y
M
S
P
E
Q
I
H
------
G
N
S
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
------
L
Y
P
F
S
T
Q
---
M
E
R
--
V
R
T
L
T
D
V
-
R
-
N
--
L
-
K
-
F
---
P
-
P
--
L
F
----------
T
Q
K
Y
P
C
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
72.54
28%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[4-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
--
K
LS
A
---
R
---------
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
----------------------------------------------------------------------------------------------------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
------
Y
----
S
E
A
D
----
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
--
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
----
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
--------------------
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
------
L
V
G
Y
P
P
F
W
D
-
E
D
Q
--
H
R
L
Y
Q
Q
I
K
A
-
G
A-
Y
-
D
-
F
---
P
-
S
P-
E
W
----------
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
70.56
28%
-
- C1 -
-
3QD2
-
E2AK3_MOUSE
B:
[583-1073]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Y
L
T
D
F
E
P
I
Q
C
M
G
R
G
-
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
NR
E
------
L
---------
A
R
E
K
V
M
R
E
V
K
A
L
A
K
L
-
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
T
P
P
E
K
W
Q
E
E
M
D
E
-------------------------------------------------------------------------------
P
K
V
--------
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
R
R
C
S
L
E
D
-------
R
E
H
G
V
----
C
L
H
I
F
I
Q
I
A
E
A
V
E
F
L
H
S
K
G
--
L
M
H
R
D
L
K
P
S
N
I
F
F
T
M
D
D
-------
V
V
K
V
G
D
F
G
L
V
T
A
M
D
Q
D
--------------------
T
H
--
T
G
Q
V
-
T
K
L
Y
M
S
P
E
Q
I
H
------
G
N
N
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
------
L
Y
S
F
S
T
Q
---
M
E
R
--
V
R
I
I
T
D
V
-
R
-
N
--
L
-
K
-
F
---
P
-
L
--
L
F
----------
T
Q
K
Y
P
Q
E
H
M
M
V
Q
D
M
L
S
P
S
P
T
E
R
P
E
A
T
D
I
I
E
N
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
67.20
25%
-33
- C1 -
-
1KOB
1
?
A:
[51-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
--
Y
------
P
L
--------
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
----------------------------------------------------------------------------------------------------
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
Y
-----
K
----
M
S
E
A
E
----
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
--
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
-----
K
K
A
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
---------------------
E
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
------
L
S
G
L
S
P
F
A
G
-
E
D
D
--
L
E
T
L
Q
N
V
K
R
-
C
D
-
W
-
E
F
D
---
E
-
D
--
A
F
----------
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
66.60
20%
-74
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[22-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
--
G
------
T
---------
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
----------------------------------------------------------------------------------------------------
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
F
-----
E
L
----
N
E
R
E
----
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
-----
R
R
S
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
---------------------
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
------
L
S
G
I
N
P
F
L
A
-
E
T
N
--
Q
Q
I
I
E
N
I
M
N
A
E
--
Y
-
T
-
F
---
D
E
E
--
A
F
----------
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
66.49
18%
-40
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
--
G
------
T
---------
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
----------------------------------------------------------------------------------------------------
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
F
E
L
N
---------
E
R
E
----
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
-----
T
R
R
S
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
N
F
R
L
L
F
---------------------
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
------
L
S
G
I
N
P
F
L
A
-
E
T
N
--
Q
Q
I
I
E
N
I
M
N
-
A
EY
T
-
F
-
D
---
E
-
E
--
A
F
----------
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
-
Y
Y
H
T
L
IKKDLN
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
--
V
A
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
65.72
26%
-3
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[9-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
--
R
------
T
KSSRRGV--
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
----------------------------------------------------------------------------------------------------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
----------
L
T
E
E
E
----
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
---
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---------------------
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
------
L
S
G
A
S
P
F
L
G
-
D
T
K
--
Q
E
T
L
A
N
V
S
A
V
N
--
Y
-
E
-
F
E--
D
-
E
--
Y
F
----------
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
65.62
25%
-35
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[90-348]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
--
G
M
-----
K
---------
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
----------------------------------------------------------------------------------------------------
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
Y
-----
N
L
----
T
E
L
D
----
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
--
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
-----
R
D
A
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---------------------
E
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
------
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
------
L
S
G
L
S
P
F
L
G
-
D
N
D
--
A
E
T
L
N
N
I
L
A
C
R
--
W
-
D
-
L
---
E
D
E
--
E
F
----------
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
65.55
26%
-18
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
--
A
------
E
RLSPEQLEE
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
----------------------------------------------------------------------------------------------------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
------
L
----
S
E
K
E
----
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
-------
D
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
---------------------
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
------
L
A
G
S
P
P
F
W
H
-
R
R
Q
--
I
L
M
L
R
M
I
M
E
-
G
--
Q
Y
Q
-
F
S--
S
-
P
--
E
W
----------
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
64.79
26%
-6
* C1 *
-
4B4L
3
DAPK1_HUMAN
A:
[11-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
--
R
------
T
KSSRRGV--
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
----------------------------------------------------------------------------------------------------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
----------
L
T
E
E
E
----
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
---
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---------------------
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
------
L
S
G
A
S
P
F
L
G
-
D
T
K
--
Q
E
T
L
A
N
V
S
A
V
N
--
Y
-
E
-
F
E--
D
-
E
--
Y
F
----------
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
64.71
26%
-24
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
-----------RLSPEQLEE
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
----------------------------------------------------------------------------------------------------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
------
L
----
S
E
K
E
----
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
-------
D
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
---------------------
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
------
L
A
G
S
P
P
F
W
H
-
R
R
Q
--
I
L
M
L
R
M
I
M
E
-
G
--
Q
Y
Q
F
S
---
S
-
P
--
E
W
----------
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
62.34
26%
-14
- C1 -
-
5O2C
4
WNK3_HUMAN
A:
[26-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
R
--
K
LT
K
---
A
---------
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
-
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
-----------------------------------------------------------------
K
-------------------------------
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
------
V
M
----
K
P
K
V
----
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
PP
I
I
H
R
D
L
K
C
D
N
I
F
I
T
------
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
----------------------
S
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
------
E
-
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
------
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
--
A
Q
I
Y
R
K
V
T
S
----
G
-
I
-
K
---
P
-
A
S
-
F
N
----------
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
62.22
23%
-24
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
--
K
F
T
S
SPG
L
---------
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
----------------------------------------------------------------------------------------------------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
---
G
F
---
V
Y
S
E
A
V
----
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
----
E
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
--------------------
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
------
L
S
G
C
L
P
F
Y
G
--
T
K
--
E
R
L
F
E
G
I
I
K
-
G
KY
K
-
M
-
N
---
P
-
R
--
Q
W
----------
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
61.10
23%
-21
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
--
K
F
T
S
SPG
L
---------
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
----------------------------------------------------------------------------------------------------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
---
G
F
---
V
Y
S
E
A
V
----
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
----
E
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
--------------------
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
------
L
S
G
C
L
P
F
Y
G
--
T
K
--
E
R
L
F
E
G
I
I
K
-
G
K
Y
K
-
M
-
N
---
P
-
R
--
Q
W
----------
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
61.02
12%
-
- C1 -
-
3QA8
-
?
A:
[16-666]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
K
E
R
L
G
T
G
G
F
G
Y
V
L
R
W
I
H
Q
D
T
G
E
Q
V
A
I
K
Q
C
R
Q
E
L
S
P
K
N
R
E
R
W
C
L
E
I
Q
I
M
K
K
L
N
H
P
N
V
V
S
A
R
E
V
P
D
G
L
Q
K
L
A
P
N
D
L
P
L
L
A
M
E
Y
C
E
G
G
D
L
R
K
Y
L
N
Q
F
E
N
C
C
G
-------
L
K
E
G
P
----
I
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
N
R
--
I
I
H
R
D
L
K
P
E
N
I
V
L
Q
P
G
P
Q
R
L
----
I
H
K
I
I
D
L
G
Y
A
K
E
L
D
Q
G
E
L
C
T
E
F
V
---------------------
G
T
L
Q
Y
L
A
P
E
L
L
E
------
Q
K
K
Y
T
V
T
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
TGFRP
F
L
P
N
W
Q
P
V
Q
-
W
H
G
--
K
V
R
I
V
V
Y
D
D
-
L
--
T
-
G
-
A
---
V
-
K
--
F
S
S
VLPTPNHLS
G
I
L
A
G
K
L
E
R
W
L
Q
C
M
L
M
W
H
Q
R
T
D
P
Q
N
P
N
V
G
C
F
Q
A
L
D
S
I
L
S
L
K
L
L
S
V
M
N
M
V
S
G
R
V
H
T
Y
P
V
T
------
E
N
E
N
L
Q
N
L
K
S
W
L
Q
Q
D
T
G
I
P
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
N
S
A
Q
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
D
N
R
K
I
S
L
P
A
H
P
E
-
S
V
S
I
V
L
Q
D
P
K
R
P
L
T
Y
T
H
L
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
C
A
R
L
L
Q
G
Q
R
T
S
M
V
N
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
K
L
D
F
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
Q
M
E
F
G
I
T
S
E
K
L
L
S
A
W
R
E
M
E
Q
A
V
E
L
C
G
R
E
R
E
V
Q
A
L
V
D
K
M
M
A
L
Q
T
D
S
V
D
L
Q
R
N
P
T
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
R
P
R
D
Q
R
T
P
G
D
S
N
D
M
V
R
L
L
I
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
L
S
P
K
V
K
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
S
K
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
59.92
23%
-40
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
--
P
------
G
E--------
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
----------------------------------------------------------------------------------------------------
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
G
P
----------
L
S
E
L
Q
----
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
--
K
M
H
R
D
I
K
G
A
N
I
L
L
T
-------
D
N
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
--------------------
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER---
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
------
A
E
L
Q
P
P
M
F
D
-
L
H
P
--
M
R
A
L
F
L
M
T
K
-
S
--
N
F
Q
-
P
---
P
-
K
LK
D
K
----------
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
59.16
21%
-35
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[94-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
------
Q
Q--------
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
----------------------------------------------------------------------------------------------------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
----
N
E
E
Q
----
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
T
-------
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--------------------
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
------
V
D
G
E
P
P
Y
F
N
-
E
P
P
--
L
K
A
M
K
M
I
R
D
-
N
L-
P
-
P
-
R
---
L
-
K
--
N
L
----------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
58.42
24%
-23
- C1 -
-
3UIU
-
E2AK2_HUMAN
A:
[262-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
G
M
D
F
K
E
I
E
L
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
R
I
D
G
K
T
Y
V
I
R
R
V
-----
K
------
Y
---------
N
N
E
K
A
E
R
E
V
K
A
L
A
K
L
-
D
H
V
N
I
V
H
Y
N
G
C
W
--
D
G
--------
F
D
Y
D
P
E
T
S
----------------------------------------------------------------
R
S
K
T
K
---------------
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
E
Q
W
I
E
K
R
------------
R
G
E
K
L
D
K
V
L
A
L
E
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
--
L
I
H
R
D
L
K
P
S
N
I
F
L
-------
V
D
T
K
Q
V
K
I
G
D
F
G
L
V
---------------------
T
S
L
-----------
T
L
R
Y
M
S
P
E
Q
I
----------
Y
G
K
E
V
D
L
Y
A
L
G
L
I
L
A
E
L
-------
L
H
V
C
D
T
A
F
-
E
T
S
K
F
F
T
D
L
----
R
-
D
--
G
-
I
-
I
---
S
-
D
--
I
F
----------
D
K
K
E
K
T
L
---
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
58.27
27%
-99
- C1 -
-
1ZXE
1
GCN2_YEAST
A:
[89-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
F
I
Q
M
E
Y
C
E
N
R
T
L
Y
D
L
I
H
S
E
N
L
N
Q
Q
R
D
E
Y
W
R
-------------
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
--
I
I
H
R
N
L
K
P
M
N
I
F
I
D
-------
E
S
R
N
V
K
I
G
D
F
G
L
A
K
---
N
---------------------------
A
I
G
T
A
M
Y
V
A
T
E
V
L
D
------
G
-
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
------
I
Y
P
F
S
T
G
---
M
E
R
--
V
N
I
L
K
K
L
-
R
-
S
--
V
-
S
-
I
EFP
P
-
D
--
F
D
----------
D
N
K
M
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------