@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_12_0016: (2018-03-08 )
MGDHLGSRFTVIEQIGSGNYGSLYRVIDGEAATLADRIIATKKLQDTINHPHVLREVSVQRHAQKCSPHIVKLLHVVPRDRVRAALVLEYVPLDLRTFLNAFYCDQAKSSAPTWCATAGAGEVKSAAPPPCHIPLIYVRRMLRGLIEALHCLHARGIVHRDVKPENILVEPLGLGHPLRCVCPPMGSFGPTGEAAGCWVHAPQCSDPRQEKDATQPMQPRGTLEPCQFFCRNSVALHHELTGDELASAIHRLHCETCRPCPRARAGVGKHPLQQHRDRSDMKTSNSCSQERQADAVDGEGPASVDDDEENKFTAPTPPPLMPDVKLCDFGSARHIGTLRLRSAEEQREELTPGPTTPVYCAPEMMLLQRYGTSVDMWAVGAILFEMLTGEFFLGVGTLRSFSGDVVVQDDYCVMHRLNRMFRHLGTPSVEEWRCIAHPHYYPDEMLAHLPQVRDAALFRCLAQPIATDVSLLPESGDIKPNGDAKTADEQTELSVRPSAETCSFAQAPVNGTTDSHAARASVPPRDMASARHPLNVSDFLYQHIGKSGVDFLRSLLRYDPAKRMTSAEALRHPFLSPEVANM
Atome Classification :
(20 SA)
----------------------.........10........20.......---.-30.........40....---...----.50..-......60......-..70........-----80----.----........90..-......100.......110.......120.......130.......140.......150.......160.......170-------........180.......190.......200.......210.......220.......230...-------....240.......250..-------.....260---.........270.....-..280......--.-290.......300.--......310...---....320.......330...-....340.......350.......360......-.370.......380.......-------------390.......400.......410.......420.......430.......440........450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------MGDHLG
S
R
F
T
V
I
E
Q
IGSGNYG
S
L
Y
R
VID---G-
E
-
A
A
T
L
A
D
R
I
I
A
T
K
K
L
Q
---
D
TI----N
H
P
H
V
-
L
R
E
V
S
V
Q
R
H
A
Q
KC
S
-
P
H
I
V
K
L
L
H
VV
P
R
-----
D
-----
R
----
V
R
A
A
L
V
L
E
YVP
L
-
D
L
R
T
F
L
N
A
F
Y
CDQAKSSAP
T
W
C
ATAGAGEVKSAAPPPCHI
P
L
I
Y
V
R
R
M
L
R
G
L
I
E
A
L
H
C
L
H
ARGIVHRDVKPE
N
I
L
V
EP--------LGLGHP
L
R
C
VCPPMGSFGPTGEAA
G
C
W
V
HAPQCSDPRQEKDATQPMQPRGT
L
E
P
C
Q
F
F
C
RNS
V
A
-------
L
HHEL
T
G
D
E
L
A
S
A
I
H
R
L
H
C
-------
E
TCRPC-----PRARAGVGKH
P
L
Q
Q
H
RD-RSDMKTSNSCS--
Q
-
E
RQADAVDGEGPAS--VDDDEENKFTAP---TPPPLMPDVKLCDFGSAR
H
I
-
G
T
L
R
LR
S
A
E
E
Q
R
E
ELTPGPTT
P
V
YC
A
P
E
M
M
L
L
Q
-
R
YGTS
V
D
M
W
A
V
G
A
I
L
F
E
MLTG-------------
E
F
F
L
G
V
G
T
L
RSFSG
D
V
V
V
QD
D
Y
C
V
M
H
R
L
N
R
M
F
R
HLGTP
S
V
E
E
W
R
C
IAHPHY
Y
-
P
D
E
M
L
A
H
L
P
Q
V
R
D
A
A
L
F
R
C
L
A
Q
P
I
A
T
D
V
SLLPESGDIKPNGDAKTADEQT
E
L
S
VRPSAETCSFAQAPVNGTTDSHAARASVP
P
R
D
M
ASARHPL
N
V
S
D
F
L
Y
Q
H
I
G
K
S
G
V
D
F
L
R
S
L
LRYD
P
A
K
RM
T
S
A
E
A
L
RHPFLSPEVANM
25
HHSearch
80.70
31%
-108
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-240]
-------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
---
K
-
N
-
T
----
N
Q
I
V
A
I
K
K
I
------------
N
R
T
A
-
L
R
E
I
K
L
L
Q
E
L
S
--
H
-
P
N
I
I
G
L
L
D
A
F
G
H
-----------
K
----
S
N
I
S
L
V
F
D
F
M
E
T
-
D
L
E
V
I
I
K
D
N
S
---------------------------
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
-
G
S
P
N
--------
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
-------------
V
P
F
--------
L
P
G
D
S
D
-------
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
----------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
80.25
31%
-69
- C1 -
-
4NM5
4
GSK3B_HUMAN
A:
[39-270]
-------------------------
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
---
C
-
D
-
S
----
G
E
L
V
A
I
K
K
V
L
---
Q
D
K
------
R
F
K
-
N
R
E
L
Q
I
M
R
K
L
D
--
H
-
C
N
I
V
R
L
R
Y
F
F
Y
S
-----
S
G
EKKD
E
----
V
Y
L
N
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
H
Y
S
R
------------------------
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
--------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
-
V
R
G
---------
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
-------------
Q
P
I
--------
F
P
G
D
S
G
-------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
80.15
32%
-67
* C1 *
-
1J1B
1
GSK3B_HUMAN
B:
[53-282]
---------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
---
C
-
D
-
S
----
G
E
L
V
A
I
K
K
V
L
---
Q
D
K
------
R
F
K
-
N
R
E
L
Q
I
M
R
K
L
D
--
H
-
C
N
I
V
R
L
R
Y
F
F
Y
S
-----
S
GEKKD
E
----
V
Y
L
N
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
H
Y
S
R
A
------------------------
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
--------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
-
V
R
G
---------
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
-------------
Q
P
I
--------
F
P
G
D
S
G
-------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
67.99
16%
-15
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
---------------------N
F
E
Q
S
L
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
T
V
V
F
Q
G
S
---
F
-
Q
-
G
R
P
V
A
V
K
R
M
L
I
D
F
C
D
---
I
A
L
----
M
E
I
K
L
-
L
T
E
S
D
D
H
--------
P
N
V
I
R
-
Y
Y
C
S
E
T
-----
T
-----
D
----
R
F
L
Y
I
A
L
E
L
C
N
L
-
N
L
Q
D
L
V
E
S
K
Y
---------------------------------
N
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
S
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
R
F
T
A
D
Q
---
Q
T
G
A
E
N
L
R
I
L
I
S
D
F
G
L
C
K
K
L
D
S
T
S
G
W
R
A
P
E
L
L
E
E
S
N
N
L
Q
T
K
------------
R
-
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
GKHPFGDKYS
R
E
S
N
I
I
R
G
I
F
S
L
D
E
M
K
C
L
H
D
R
S
L
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
P
S
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
D
W
T
V
K
F
D
K
T
F
M
D
R
K
Y
H
S
S
K
--
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
N
-----
L
S
D
D
Q
I
L
R
E
F
L
Y
S
------
35
HHSearch
56.48
27%
-122
- C1 -
-
4AU8
1
CDK5_HUMAN
A:
[4-141]
--------------------------
G
S
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
---
R
-
E
-
T
----
H
E
I
V
A
L
K
R
V
------------
P
S
S
A
-
L
R
E
I
C
L
L
K
E
L
K
--
H
-
K
N
I
V
R
L
H
D
V
L
H
------------------
K
L
T
L
V
F
E
F
C
D
Q
-
D
L
K
K
Y
F
D
S
C
N
---------------------------
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.62
27%
-79
- C1 -
-
2DS1
-
CDK2_HUMAN
A:
[4-173]
------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
---------
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
--
H
-
P
N
I
V
K
L
L
D
V
I
H
T
-----
E
-----
N
-----
K
L
Y
L
V
F
E
H
V
H
Q
-
D
L
K
T
F
M
D
A
-------------
S
A
L
T
G
-------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
EG
A
I
K
L
A
D
F
G
L
A
---
R
A
F
G
V
P
V
R
T
Y
--
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
54.32
27%
-148
- C1 -
-
3EB0
2
?
A:
[6-195]
---------------------------
S
K
K
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
---
I
-
E
-
S
----
G
K
R
F
A
L
K
K
V
L
---
Q
D
P
------
R
Y
K
-
N
R
E
L
D
I
M
K
V
L
D
--
H
-
V
N
I
I
K
L
V
D
Y
F
Y
T
-----
T
-----
N
----
K
Y
L
N
V
I
M
E
Y
V
P
D
-
T
L
H
K
V
L
K
S
F
I
R
S
------------------------
G
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
53.00
16%
-
- C1 -
-
3H4J
-
SNF1_SCHPO
B:
[27-356]
----------------------
S
K
R
H
I
G
P
-
Y
I
I
R
E
T
L
G
E
G
S
F
G
K
V
K
L
A
T
H
---
Y
K
T
-
Q
Q
K
V
A
L
K
F
I
S
R
Q
L
L
K
---
K
S
D
----
M
H
M
R
V
-
E
R
E
I
S
Y
L
K
L
L
R
H
---
P
H
I
I
K
L
Y
D
V
I
T
T
-----
P
-----
T
-----
D
I
V
M
V
I
E
Y
A
G
-----------------------------
G
E
L
F
D
Y
I
V
E
K
K
R
M
T
E
D
E
G
R
R
F
F
Q
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
D
D
-----------
N
L
N
V
K
I
A
D
F
G
L
S
N
I
M
T
D
G
N
F
L
K
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
N
G
K
L
Y
A
-
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
V
GRLPFDD
E
F
I
P
N
L
F
K
K
V
N
S
C
V
Y
V
M
P
D
-------
F
L
S
P
G
A
-----
Q
S
L
I
R
R
M
I
V
A
D
P
M
Q
R
I
T
-
I
Q
E
I
R
R
D
P
W
F
N
--
V
-
N
L
P
D
Y
L
R
P
M
E
E
V
Q
G
SY
A
D
S
R
I
V
S
K
L
G
E
A
MGF
S
E
D
Y
I
V
E
A
L
R
S
D
E
N
N
E
V
K
E
A
-
Y
N
L
L
H
E
N
Q
V
I
Q
E
K
L
E
H
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
49.92
26%
-44
- C1 -
-
5UQ1
-
CDK2_HUMAN
A:
[7-176]
------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
---------------
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
--
H
-
P
N
I
V
K
L
L
D
V
I
H
T
-----
E
-----
N
-----
K
L
Y
L
V
F
E
F
L
H
Q
-
D
L
K
K
F
M
D
A
-------------
S
A
L
T
G
-------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
EG
A
I
K
L
A
D
F
G
L
A
---
R
A
F
G
V
P
V
R
T
Y
--
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
49.58
26%
-57
- C1 -
-
5G6V
1
B:
[2-146]
----------------------------
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
---
K
-
L
-
T
----
D
N
L
V
A
L
K
E
I
R
---
L
E
H
EEG-
A
P
C
T
A
-
I
R
E
V
S
L
L
K
D
L
K
--
H
-
A
N
I
V
T
L
H
D
I
I
H
T
-----------
E
----
K
S
L
T
L
V
F
E
Y
L
D
K
-
D
L
K
Q
Y
L
D
D
C
G
---------------------------
N
I
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
48.66
26%
-43
- C1 -
-
5UQ2
-
CDK2_HUMAN
A:
[7-176]
------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
---------
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
--
H
-
P
N
I
V
K
L
L
D
V
I
H
T
-----
E
-----
N
-----
K
L
Y
L
V
F
E
F
L
H
Q
-
D
L
K
K
F
M
D
A
-------------
S
A
L
T
G
-------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
EG
A
I
K
L
A
D
F
G
L
A
---
R
A
F
G
V
P
V
R
T
Y
--
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
48.61
25%
-66
- C1 -
-
1KOB
-
?
A:
[50-183]
---------------------------
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
---
K
-
A
-
T
----
G
R
V
F
V
A
K
F
I
N
---
T
P
Y
P
L
--
D
K
Y
T
V
-
K
N
E
I
S
I
M
N
Q
L
H
--
H
-
P
K
L
I
N
L
H
D
A
F
E
D
-----------
K
----
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
---------------------------
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
48.33
26%
-52
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[2-139]
----------------------------
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
---
K
-
L
-
T
----
D
N
L
V
A
L
K
E
I
R
---
L
E
H
EEG-
A
P
C
T
A
-
I
R
E
V
S
L
L
K
D
L
K
--
H
-
A
N
I
V
T
L
H
D
I
I
H
T
-----------
E
----
K
S
L
T
L
V
F
E
Y
L
D
K
-
D
L
K
Q
Y
L
D
D
C
G
---------------------------
N
I
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
48.23
14%
26
- C1 -
-
1KOB
1
?
A:
[23-374]
INDYDKFYEDIWKK
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
---
K
-
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
---
D
K
Y
----
T
V
K
N
E
-
I
S
I
M
N
Q
L
H
H
------
P
K
L
I
N
L
H
D
A
F
E
------
D
-----
K
----
Y
E
M
V
L
I
L
E
F
L
---------------------------
S
G
G
E
L
F
D
R
I
A
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
--------
K
K
-
A
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
R
--
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
GLS----
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
-------
E
F
D
E
D
A
FSSVS
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
-
R
L
T
V
H
D
A
L
E
H
P
--
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
--
R
Y
N
K
I
R
Q
K
I
K
E
K
---
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
-
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
47.62
12%
-8
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
---
T
-
S
-
S
----
K
K
T
Y
M
A
K
F
V
K
V--
K
G
T
----
D
Q
V
L
V
-
K
K
E
I
S
I
L
N
I
A
R
H
---
R
N
I
L
H
-
L
H
E
S
F
E
-----
S
-----
M
----
E
E
L
V
M
I
F
E
F
I
S
---------------------------
G
L
D
I
F
E
R
I
N
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
--------
R
R
-
S
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
--
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-------
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
AEYTFDE
E
A
F
K
E
I
-----
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
WL
K
-
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
--
K
H
R
R
Y
Y
H
T
L
I
K
K
---
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
-
K
G
V
S
V
A
K
V
K
V
A
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
46.07
29%
-35
- C1 -
-
3G33
-
CDK4_HUMAN
A:
[10-153]
-----------------------------
R
Y
E
P
V
A
E
I
G
V
G
A
Y
G
T
V
Y
K
A
R
D
PHS
G
-
H
-
F
V
A
L
K
S
V
R
V
P
N
G
G
G
G
---
G
G
G
----
L
P
I
S
T
-
V
R
E
V
A
L
L
R
R
L
E
A
F
E
H
P
N
V
V
R
L
M
D
V
C
A
T
-----
S
-----
R
TDR
E
I
K
V
T
L
V
F
E
H
V
D
Q
-
D
L
R
T
Y
L
D
K
-------------------------
A
P
P
P
G
-
L
P
A
E
T
I
K
D
L
M
R
Q
F
L
R
G
L
D
F
L
H
A
N
C
I
V
H
R
D
L
K
P
E
N
I
L
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
45.97
26%
-33
- C1 -
-
4ERW
13
CDK2_HUMAN
A:
[12-180]
------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
---------
K
L
T
G
E
V
V
A
L
K
K
I
R
L---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
--
H
-
P
N
I
V
K
L
L
D
V
I
H
T
-----
E
-----
N
-----
K
L
Y
L
V
F
E
F
L
H
Q
-
D
L
K
K
F
M
D
A
-------------
S
A
L
T
G
-------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
EG
A
I
K
L
A
D
F
G
L
A
---
R
A
F
G
V
P
V
R
T
Y
--
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
45.25
24%
-67
- C1 -
-
2WEL
6
KCC2D_HUMAN
A:
[2-141]
--------------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
---
I
-
P
-
T
----
G
Q
E
Y
A
A
K
I
I
N
---
T
K
K
LS
A
R
D
H
Q
K
L
-
E
R
E
A
R
I
C
R
L
L
K
--
H
-
P
N
I
V
R
L
H
D
S
I
S
E
-----------
E
----
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----------------------------
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
45.08
27%
-46
- C1 -
-
5BYZ
5
MK07_HUMAN
A:
[4-144]
--------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
---
R
-
L
-
T
----
G
Q
Q
V
A
I
K
K
I
P
---
N
A
F
DV
V
T
N
A
K
R
T
-
L
R
E
L
K
I
L
K
H
F
K
--
H
-
D
N
I
I
A
I
K
D
I
L
R
P
TVPYG
E
-----
F
----
K
S
V
Y
V
V
L
D
L
M
E
S
-
D
L
H
Q
I
I
H
S
S
----------------------------
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
44.98
28%
-30
- C1 -
-
4EON
1
CDK2_HUMAN
A:
[6-141]
------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
---------
K
L
T
G
E
V
V
A
L
K
K
I
R
LDT
E
T
E
----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
--
H
-
P
N
I
V
K
L
L
D
V
I
H
T
-----
E
-----
N
-----
K
L
Y
L
V
F
E
F
L
S
M
-
D
L
K
K
F
M
D
A
-------------
S
A
L
T
G
-------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
--------
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------