@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_14_0020: (2018-03-08 )
MSLRVRLRVPKQWDRFQVNIDEELQQEELSRTLTEREIDDFNRRNLHSVSELSDHLRLLVFGSDECVTCSEDICAAVEYIVGPQRRWNSSCDEVCEFRRAISRAYLNEWKAFQSVHPSVPERLATRSLPQVFSVPPLQKAQMDLLMQMCPRNAETGDGSISMRLWYLDSAGSRCSTRRRFPFDTAADDAIRLTMSSAREFASMREKTDDTPLIFVFRVKGRNEYIYGSQPLINYRYIRHCVSKRAEIDLVVEPKEATLFAVPLFRPSYPSRTLASPSDADASKSSTSEICLWDLTSKLSIRIVGGFEKLAISASRMKDENVRDSSSLYFAVLVEAYVGTWRCCEPQITDWQLCENAKNSHSLAARVYWKDGGTVTFSIDLSNVPRELKLCFTLVASSTDRIVGARAATAEEVIAAVEVNTKKTDDQGHSVFFLGTAATQLFDYAAKMRMGMWRIYLWEGKTRANPIGLNSINPDSNACTFEVEFPCFDKPVFFPSGRPPKRKEEDARRNFADREAALSSYLINNEVEQLRQLKRVLMYDPLVHLSSDDKTILWKYREMLLGQPKAMAKVMSAVNWLMPFDVYEAHCLLRRWSPLAAFDALELLDAHYADLAVREQAVEYIDKMSDYELRGCILQLVQVLKYEPYHYSALARFLLRRSLRSNHIIGHYVFWYLAAEVKNLTICERHGLLLEELIKRSPHRLDYVRQVYVCNELLKCALRVQRAPKKDRVKCLRASLAKVRFPHRFTLALNPSVECCAVDIDECKVMESKKFPLWLAFRNHLDQDEHFFIIFKSGDDLRQDLLTLQLLEFMDSLWKASGLDLHLIPYGCISTGEGVGMIEVVLNSDTIANITRREGGAQAAFNVDPIINWLRQFNHDRGEVERCLWNFVLSVAGYTVATYVLGIGDRHNDNIMLRQDGTLFHIDFGHFLGNFKTKFGIKRETAPFIFTPMYLYAMGGSSSPIFKYFVDVACRAYNALRRHSSALMMLFMLMLSTGIPELQTLEDIEWLRTVLLLNRTDEEASDHYKGLINDALGNFRTLLNDYIHIMVH
Atome Classification :
(21 SA)
.........10........20........30........40...-.....50........60........70........80..--......90........100.......110.......120.......130.......140.......150.......160.......170........180.....-..190.......200.......-210.......220.......230.......240...-------....250.......260---..---......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.....-----..----460---.........470.-.-.-....480......-.-490.......500....------...510..---.....520-..---....--.530.......540.......550.......560.-.......570.......580.......590...-----....600.......610.......620-.......630.......640.......650.......660.......670.....-..680.......690...--.-------.-..700.-......710...-....720..------..---..-.730..-----...---..---740-----.......-------.750.......760.......770......---.780.....----..790.......800.......810.......820.......830.......840.......850..--.....--860.......870.......-880.......890.......900.......910.......920.......930.......940.......950.---...---.---..960---.........970.......980.......990.......1000......1010......1020......1030.......1040....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
L
R
V
R
LRVPKQW
D
R
F
Q
VN
I
D
E
E
L
Q
Q
E
E
L
S
R
T
L
T
E
R
E
I
D
DFNRR-NLH
S
V
S
E
L
S
D
H
L
R
L
L
V
FGSDECV
T
C
S
E
D
I
C
A
A
V
E
Y
I
VGP--QRRWNS
S
C
D
E
V
C
E
F
R
R
A
I
S
R
A
Y
L
N
E
W
K
A
F
Q
SVHPS
V
P
E
R
L
A
T
RSLPQVFSVP
P
L
Q
K
A
Q
M
D
L
L
M
Q
MCPRNAETGDG
S
I
S
M
R
L
W
Y
LDSA-GSRCSTRRRFPFDTAAD-
D
A
I
R
L
T
M
S
S
A
R
E
F
A
S
M
R
EKTDD-T
P
L
I
F
V
F
R
VKGRN
E
Y
IYGSQPL
I
N
Y
R
Y
I
R
H
C
V
SKRA-------
E
I
D
L
V
VEPKE
A
T
L
F
A
V
----PL---FRPSYPSRTLASPSDADASKSSTS
E
I
C
L
W
DLTS
K
L
S
I
R
I
VGG
F
E
K
L
A
I
S
A
S
RMKDENVRDSS
S
L
Y
F
A
V
L
V
E
A
Y
VGTWRCCEPQIT
D
W
Q
L
C
E
NAKNSH
S
L
A
A
R
V
Y
W
KDG
G
T
V
T
F
S
I
DLSNV
P
R
E
L
K
L
C
F
T
L
VASSTD
R
I
VGARAA
T
A
E
E
V
I
A
A
V
E
VNTKKTDDQG
H
S
V
F
F
L
G
T
A
A
T
Q
L
F
D
Y
A
A
K
M
RM
G
M
W
R
I
Y
L
W-----EG----K-----TRANPIGLNSINP-D-S-N
A
C
T
F
E
VEFPCFD-K-PVFFPSGRPPK
R
K
E
E
D
A
------RRNF
A
D
R
E
---
A
A
L
S
S
Y
L
I
-
N
N
---
E
V
E
Q
--
L
R
Q
L
K
R
V
L
M
YDPLVHLSSDDK
T
I
L
W
K
Y
R
E
M
LL-GQ-
P
K
A
M
A
K
V
M
S
A
V
N
W
LM
P
F
D
V
Y
E
A
H
C
L
L
R
RWS
P
L
A
-----
A
F
D
A
L
E
L
L
D
A
H
Y
A
D
L
A
V
R
E
Q
A
V
E
Y
I
D
K-MSD
Y
E
L
R
G
C
I
L
Q
L
V
Q
V
LKYEPY
H
Y
S
A
L
A
R
F
L
L
R
R
S
LRSNH
I
I
G
H
Y
V
F
W
Y
L
A
A
EVK-
N
L
T
I
C
E
RH
G
L
L
L
E
E
L
I
K
R--S-------P-
H
R
L
D
Y
V
-
R
Q
V
Y
V
C
N
E
L
L
K
C
-
A
L
R
V
QRA
P
K
------
K
D
---
R
V
-
K
C
L
R
A
S
-----
L
A
K---VR---FP------
H
R
F
T
L
AL-------NPSV
E
C
C
A
V
D
I
D
E
C
K
VMESKKF
P
L
W
L
A
F
R
N---HLDQDE
H
F
F
----
I
I
F
KSG
D
D
L
R
Q
D
L
L
T
L
Q
L
L
E
F
M
D
S
L
W
KASGL
D
L
H
L
I
P
Y
G
CISTGEG
V
G
M
I
E
V
V
LNSD
T
I
A
N
I
T
RREG--GAQAA--F
N
V
D
P
I
I
N
W
L
R
Q
FNH
D
R
G
E
V
-
E
R
C
L
W
N
F
V
L
S
VA
G
Y
T
V
A
T
Y
V
L
GIGDRHND
N
I
M
L
RQD
G
T
L
F
H
I
D
F
G
H
F
LGN
F
K
T
KFGIKRETA
P
F
I
F
T
P
M
Y
L
Y
A
M---GGS---S---
S
P
I
-----
F
K
Y
F
V
D
V
A
C
R
A
Y
N
A
L
R
R
H
S
S
A
L
M
M
L
F
M
L
M
L
STGIPE
L
Q
T
L
E
D
I
E
W
L
R
T
V
L
L
LNRTD
E
E
A
S
D
H
Y
K
G
L
I
N
D
A
L
G
-
N
F
R
T
L
L
N
D
Y
I
H
I
M
VH
57
Fugue
81.79
33%
-28
- C3 -
-
4TUU
-
PK3CA_HUMAN
A:
[107-1046]
------------------
N
R
E
E
K
I
L
N
R
E
I
G
F
A
I
------
G
M
P
V
C
-
E
F
D
M
V
K
D
------------------------------------------
P
E
V
Q
D
F
R
R
N
I
-
L
N
V
C
K
E
A
V
D
L
R
D
L
N
S
P
-
H
S
R
A
M
Y
V
Y
P
P
N
V
E
S
S
P
E
L
P
K
H
I
Y
N
K
L
----------
D
K
G
Q
I
I
V
V
I
W
V
I
V
S
P
N
N
D
K
Q
K
Y
T
L
K
I
N
H
D
C
V
P
E
-
Q
V
I
A
E
A
I
R
K
K
T
R
S
M
L
Y
Q
G
K
--------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
---
D
C
F
T
M
P
S
Y
S
R
K
S
---------------
L
W
V
I
N
S
A
L
R
I
K
I
L
C
A
T
-------------
Y
V
N
V
N
D
K
I
Y
V
R
T
G
I
Y
H
--
G
G
E
P
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
----------
R
W
--
N
E
W
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
V
K
E
E
H
------------------------------
C
P
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
S
V
I
E
E
H
A
N
W
S
------
V
S
R
E
A
G
F
S
YSH
A
G
L
S
N
R
L
A
-
R
D
NEL
R
E
N
D
--
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
D
I
L
K
Q
E
K
K
------
D
E
---
T
Q
-
K
V
Q
M
K
F
-----
L
V
E
---
Q
M
---
R
R
------
P
D
F
M
D
A
L
Q
GFLSPL
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
G
----------
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
K
G
E
-
I
Y
-
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
R
-----------
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
-
T
---
K
---
T
R
E
-----
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
------------------
3
PsiBlast_PDB
80.65
33%
-
- C3 -
-
4OVU
-
PK3CA_HUMAN
A:
[250-1052]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
D
C
F
T
M
P
S
Y
S
----------
N
G
E
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
K
------
E
E
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
----R
D
N
---
E
L
R
E
ND
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
Y
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TKT
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
-----------
58
Fugue
79.04
31%
-44
- C3 -
-
1E8X
1
PK3CG_PIG
A:
[1-951]
-------------------------
A
A
S
E
E
T
L
A
F
Q
R
Q
L
N
A
L
I
G
Y
-
D
V
T
D
V
S
N
V
H
D
---------------------------------------
D
E
L
E
F
T
R
R
R
L
V
T
P
R
M
A
E
V
A
G
R
D
------
P
K
L
Y
A
M
H
P
W
V
T
S
K
P
L
P
E
Y
L
L
K
K
I
T
-------------
N
N
C
V
F
I
V
I
H
R
S
T
T
S
-
Q
T
I
K
V
S
A
D
-----------------
D
T
P
G
T
I
L
Q
S
F
F
T
K
M
A
-
N
E
R
D
F
V
L
R
V
C
G
R
D
E
Y
L
V
G
E
T
P
I
K
N
F
Q
W
V
R
Q
C
L
K
N
G
E
-------
E
I
H
L
V
L
D
T
P
P
----------------------------------------------
D
P
A
L
D
E
V
R
K
E
C
D
R
K
F
R
V
K
I
R
G
I
D
I
P
V
L
P
R
T
A
D
L
T
V
F
V
E
A
N
I
Q
Y
G
----------
Q
Q
V
L
C
Q
R
R
T
S
P
K
P
F
T
E
E
V
L
W
--
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
Q
-----------------------------------
L
L
Y
Y
V
N
L
L
L
I
D
H
R
F
L
L
R
H
G
E
Y
V
L
H
M
W
-----
Q
L
----
S
-----
G
F
N
A
D
K
L
T
S
A
T
N
P
-
D
K
E
-
N
S
M
S
I
S
I
L
L
D
N
H
P
-
I
-
A
L
E
M
P
N
--------------------------------------------
Q
L
--
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
-
K
D
-
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
I
V
A
K
T
Y
Q
L
L
A
K
R
E
V
W
D
Q
SALD
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
-
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
S
A
L
A
R
F
L
L
K
R
G
L
R
-
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
CG
T
-------
A
-
M
L
H
D
F
T
-
Q
Q
V
Q
V
I
D
M
L
Q
K
V
-
T
I
D
I
K
S
L
S
A
EKYDVS
S
Q
---
V
I
-
S
Q
L
K
Q
K
-----
L
E
N
---
L
Q
NLN
L
P
------
Q
S
F
R
V
P
Y
-------
D
P
G
L
K
A
G
A
L
V
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
ADP
T
A
L
S
N
E
T
I
G
----
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
--
G
N
T
G
A
--
F
K
D
E
V
L
S
H
W
L
K
E
K
C
P
I
E
E
K
F
-
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
S
E
T
G
N
L
F
H
I
D
F
G
H
V
---------------
P
F
V
L
T
P
D
F
L
F
V
M
---
G
T
S
GKK
T
---
S
L
H
-----
F
Q
K
F
Q
D
V
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
S
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
-
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
L
5
PsiBlast_PDB
78.81
33%
-38
- C3 -
-
5SWP
4
PK3CA_HUMAN
A:
[278-1082]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
DC
F
T
M
P
S
Y
S
----------
N
G
E
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
-------
E
E
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
N
R
L
A
R
D
N
---
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
Y
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
T
K
---------
10
PsiBlast_PDB
78.70
33%
-39
- C3 -
-
5SXD
1
PK3CA_HUMAN
A:
[278-1082]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
DC
F
T
M
P
S
Y
S
-------------
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
---------
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
N
R
L
A
R
D
N
---
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
-
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
T
K
---------
6
PsiBlast_PDB
78.66
33%
-40
- C3 -
-
5SWR
1
PK3CA_HUMAN
A:
[278-1080]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
D
C
F
T
M
P
S
Y
S
------------
E
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
-------
E
E
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
N
R
L
A
R
D
N
---
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
Y
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
-----------
9
PsiBlast_PDB
78.62
33%
-39
- C3 -
-
5SXC
1
PK3CA_HUMAN
A:
[278-1080]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
DC
F
T
M
P
S
Y
S
--------------
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
---------
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
N
R
L
A
R
D
N
---
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
---
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
-----------
8
PsiBlast_PDB
78.59
33%
-35
- C3 -
-
5SXB
1
PK3CA_HUMAN
A:
[278-1084]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
DC
F
T
M
P
S
Y
S
-----------
G
E
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
-------
E
E
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
N
R
L
A
R
D
N
---
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
-
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
T
K
M
D
-------
16
PsiBlast_PDB
78.58
33%
-44
- C3 -
-
5SX8
2
PK3CA_HUMAN
A:
[278-1082]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
DC
F
T
M
P
S
Y
S
----------
N
G
E
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
--------
E
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
N
R
L
A
R
D
------
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
Y
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
T
K
---------
18
PsiBlast_PDB
78.51
33%
-41
- C3 -
-
5SXK
1
PK3CA_HUMAN
A:
[278-1080]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
DC
F
T
M
P
S
Y
S
-----------
G
E
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
-------
E
E
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
N
---R
D
N
---
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
Y
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
-----------
12
PsiBlast_PDB
78.12
33%
-30
- C3 -
-
5SXI
1
PK3CA_HUMAN
A:
[278-1084]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
DC
F
T
M
P
S
Y
S
--------------
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
-------
E
E
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
N
R
L
A
R
D
N
---
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
---
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
T
K
M
D
-------
11
PsiBlast_PDB
78.10
33%
-35
- C3 -
-
5SXE
1
PK3CA_HUMAN
A:
[278-1082]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
D
C
F
T
M
P
S
Y
S
-------------
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
---------
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
N
R
L
A
R
D
N
---
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
----
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
T
K
---------
22
HHSearch
78.02
31%
-20
* C3 *
-
5VLR
1
PK3CD_HUMAN
A:
[59-1013]
--------------------------------
Q
T
A
E
Q
Q
E
L
E
D
E
Q
R
R
L
C
D
V
---
Q
P
F
L
P
V
L
R
L
V
A
R
E
G
D
R
V
K
K
L
I
N
S
Q
I
S
L
L
I
G
K
G
L
H
E
F
D
S
L
C
D
P
E
V
N
D
F
R
A
K
M
C
Q
F
C
E
E
A
---
A
A
R
R
Q
Q
L
G
W
E
A
W
L
Q
Y
S
F
P
L
Q
L
E
P
S
------------------
L
P
-
N
R
A
L
L
V
N
V
K
F
E
G
S
E
-
E
-
S
F
T
F
--
Q
V
S
T
K
D
V
P
L
-
A
L
M
A
C
A
L
R
K
K
A
T
-------------
E
D
Y
T
L
Q
V
N
G
R
H
E
Y
L
Y
G
S
Y
P
L
C
Q
F
Q
Y
I
C
S
C
L
H
S
G
L
-------
T
P
H
L
T
M
V
H
S
S
S
I
L
A
M
R
----
D
-------------------------------
L
W
S
L
E
Q
P
F
R
I
E
L
I
Q
G
S
K
V
N
A
D
E
-------------
R
M
K
L
V
V
Q
A
G
L
F
H
G
N
E
M
L
C
K
T
V
S
S
S
E
V
S
---------
V
C
S
E
P
V
W
K
Q
--
R
L
E
F
D
I
N
I
C
D
L
P
R
M
A
R
L
C
F
A
L
Y
A
V
I
E
K
A
K
---------------------------
A
D
C
P
I
A
W
A
N
L
M
L
F
D
Y
K
D
Q
L
K
T
G
E
R
C
L
Y
M
W
-----
P
S
----
V
P
DEKG
E
L
L
N
P
T
G
T
V
R
S
N
P
-
N
-
T
D
S
A
A
A
L
L
I
C
L
P
E
V
A
P
H
-
P
V
Y
Y
P
A
L
E
K
I
L
E
L
G
R
H
---------------------
T
-----------
E
E
E
--
Q
L
Q
L
R
E
I
L
E
----
G
E
L
Y
E
H
E
K
D
L
V
W
K
L
R
H
E
V
Q
E
H
F
-
P
E
A
L
A
R
L
L
L
V
T
K
W
N
K
H
E
D
V
A
Q
M
L
Y
L
L
C
S
W
P
E
L
P
-----
V
L
S
A
L
E
L
L
D
F
S
F
P
D
C
H
V
G
S
F
A
I
K
S
L
R
K
-
L
T
D
D
E
L
F
Q
Y
L
L
Q
L
V
Q
V
L
K
Y
E
S
Y
L
D
C
E
L
T
K
F
L
L
D
R
A
L
A
N
-
R
K
I
G
H
F
L
F
W
H
L
R
S
E
M
H
-
V
P
S
V
A
L
R
F
G
L
I
L
E
A
Y
C
R
G
--
S
-------
T
H
H
M
K
V
L
M
-
K
Q
G
E
A
L
S
K
L
K
A
L
-
N
D
F
V
K
L
S
S
Q
K
-----
T
P
K
P
Q
T
K
-
E
L
M
H
L
C
-----
M
R
Q
E
A
Y
L
E
---
A
L
------
S
H
L
Q
S
P
L
-------
D
P
S
T
L
L
A
E
V
C
V
E
Q
C
T
F
M
D
S
K
M
K
P
L
W
I
M
Y
S
N
---
E
E
A
---
S
V
G
----
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
M
I
Q
L
M
D
V
L
W
K
Q
E
G
L
D
L
R
M
T
P
Y
G
C
L
P
T
G
D
R
T
G
L
I
E
V
V
L
R
S
D
T
I
A
N
I
Q
L
N
-----------
F
N
K
D
A
L
L
N
W
L
K
S
K
N
P
G
-
E
A
L
-
D
R
A
I
E
E
F
T
L
S
C
A
G
Y
C
V
A
T
Y
V
L
G
I
G
D
R
H
S
D
N
I
M
I
R
E
S
G
Q
L
F
H
I
D
F
G
H
F
L
G
N
F
-----
I
N
R
E
R
V
P
F
I
L
T
Y
D
F
V
H
V
I
---
Q
Q
G
---
K
TNN
S
E
K
-----
F
E
R
F
R
G
Y
C
E
R
A
Y
T
I
L
R
R
H
G
L
L
F
L
H
L
F
A
L
M
R
A
A
G
L
P
E
L
S
C
S
K
D
I
Q
Y
L
K
D
S
L
A
L
G
K
T
E
E
E
A
L
K
H
F
R
V
K
F
N
E
A
L
R
E
S
W
K
T
-----------
15
PsiBlast_PDB
77.72
33%
-39
- C3 -
-
5SWO
2
PK3CA_HUMAN
A:
[278-1080]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
DC
F
T
M
P
S
Y
S
----------
N
G
E
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
-------
E
E
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
N
R
L
A
R
D
N
---
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
Y
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
-----------
20
PsiBlast_PDB
77.43
33%
-34
- C3 -
-
4L23
2
PK3CA_HUMAN
A:
[250-1058]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
D
C
F
T
M
P
S
Y
S
-----------
G
E
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
K
G
---
A
K
E
E
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
-------------
N
R
L
A
R
D
N
---
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
------------
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
Y
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TKT
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
T
K
M
D
W
I
-----
7
PsiBlast_PDB
77.43
33%
-34
- C3 -
-
5SWT
2
PK3CA_HUMAN
A:
[278-1082]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
D
C
F
T
M
P
S
Y
S
-----------
G
E
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
-------
E
E
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
N
R
L
A
R
D
N
---
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
-
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
T
K
---------
14
PsiBlast_PDB
76.80
33%
-15
- C3 -
-
5SWG
1
PK3CA_HUMAN
A:
[278-1080]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
DC
F
T
M
P
S
Y
S
-------------
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
-------
E
E
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
N
----
D
N
---
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
Y
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
-----------
4
PsiBlast_PDB
76.00
33%
-17
- C3 -
-
4OVV
1
PK3CA_HUMAN
A:
[278-1081]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
DCF
T
M
P
S
Y
S
------------
E
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
--------
E
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
S
-----
D
N
---
E
L
R
E
ND
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
Y
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TKT
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
T
----------
17
PsiBlast_PDB
75.81
33%
-21
- C3 -
-
5SXF
-
PK3CA_HUMAN
A:
[278-1079]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
DC
F
T
M
P
S
Y
S
---------------
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
N
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
---------
H
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
L
-----------
E
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
----
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
----
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
------------
13
PsiBlast_PDB
75.20
33%
-15
- C3 -
-
5SW8
4
PK3CA_HUMAN
A:
[278-1081]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
-------
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
----
P
M
DC
F
T
M
P
S
Y
S
R
-----------
E
T
S
T
K
S
---
L
W
V
I
N
S
A
L
R
I
K
I
L
---------
C
A
T
Y
V
N
V
-
I
R
D
I
D
K
I
Y
------
V
R
T
G
I
Y
H
G
G
E
P
------
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
--
W
N
E
W
--
L
N
Y
D
I
Y
I
P
D
L
P
R
A
A
R
L
C
L
S
I
C
S
------
V
----------
C
P
------------------
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
-----
P
V
PHGL
E
-----
D
L
L
N
P
I
G
V
T
G
S
N
P
-
N
-
K
-
E
T
P
C
L
E
L
E
F
D
W
F
S
-
S
-
V
V
K
F
P
D
M
---
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
H
---
A
G
--------
N
---
E
L
R
E
ND
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
-
T
I
-
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
-----
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
F
L
L
K
K
A
L
-
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
-
N
K
T
V
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
--
C
-------
G
-
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
-
T
-
D
I
L
K
Q
E
K
------
K
D
---
E
T
-
Q
K
V
Q
M
K
F
L
---
V
E
Q
---
M
R
---
R
P
D
F
M
D
A
L
Q
G
F
L
S
P
L
-------
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-
G
--
G
L
K
G
A
LQ
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
--
K
G
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
----
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
---
S
K
G
---
A
---
Q
E
C
TK
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
-
G
G
W
T
T
----------
1
PsiBlast_PDB
74.41
33%
-15
- C3 -
-
2Y3A
1
PK3CB_MOUSE
A:
[232-1071]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Q
V
S
P
N
L
N
P
I
K
I
N
E
L
A
I
Q
K
R
L
T
-------A
S
P
C
D
Y
V
L
Q
V
S
G
R
V
E
Y
V
F
G
D
H
P
L
I
Q
F
Q
Y
I
R
N
C
V
M
N
R
T
L
P
H
F
I
L
V
E
C
C
K
I
K
K
M
Y
E
Q
E
M
I
A
I
E
AAI--------------------------------
I
W
D
N
N
N
P
F
Q
I
T
L
V
K
G
-------------
N
K
L
N
T
E
E
T
V
K
V
H
V
R
A
G
L
F
H
G
T
E
L
L
C
K
T
V
V
S
S
E
I
---
S
G
K
N
D
H
------
I
W
N
E
--
Q
L
E
F
D
I
N
I
C
D
L
P
R
M
A
R
L
C
F
A
V
Y
A
V
------------------------------------
V
A
W
V
N
T
M
V
F
D
F
K
G
Q
L
R
S
G
D
V
I
L
H
S
W
S
SFPD
E
L
----
E
-----
E
M
L
N
P
M
G
T
V
Q
T
N
P
Y
A
-
E
-
N
A
T
A
L
H
I
T
F
P
E
N
K
-
K
Q
P
C
Y
Y
P
---
P
F
D
K
I
I
E
K
A
------
A
E
L
A
---------------------
G
K
K
F
--
L
A
V
L
K
E
I
L
D
R
D
P
L
S
Q
L
C
E
N
E
M
D
L
I
W
T
L
R
Q
D
C
R
-
E
N
F
P
Q
S
L
P
K
L
L
L
S
I
K
W
N
K
L
E
D
V
A
Q
L
Q
A
L
L
Q
I
W
P
K
L
P
-----
P
R
E
A
L
E
L
L
D
F
N
Y
P
D
Q
Y
V
R
E
Y
A
V
G
C
L
R
Q
-
M
S
D
E
E
L
S
Q
Y
L
L
Q
L
V
Q
V
L
K
Y
E
P
F
L
D
C
A
L
S
R
F
L
L
E
R
A
L
-
D
N
R
R
I
G
Q
F
L
F
W
H
L
R
S
E
V
H
-
T
P
A
V
S
V
Q
F
G
V
I
L
E
A
Y
C
R
G
--
S
VGH
M
K
V
L
S
-
K
Q
V
E
A
L
-
N
K
L
K
T
L
N
S
L
I
K
L
N
A
V
K
L
S
R
A
K
G
------
K
E
---
A
M
H
T
C
L
K
Q
S
A
Y
R
E
A
L
S
D
---
L
Q
---
S
P
------------
L
-------
N
P
C
V
I
L
S
E
L
Y
V
E
K
C
K
Y
M
D
S
K
M
K
P
L
W
L
V
Y
S
S
---
R
A
F
G
E
D
S
V
G
----
V
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
M
L
R
L
M
D
L
L
W
K
E
A
G
L
D
L
R
M
L
P
Y
G
C
L
A
T
G
D
R
S
G
L
I
E
V
V
S
T
S
E
T
I
A
D
I
Q
L
N
S
S
NV
A
A
T
A
A
--
F
N
K
D
A
L
L
N
W
L
K
E
Y
N
S
G
-
D
D
L
-
D
R
A
I
E
E
F
T
L
S
C
A
G
Y
C
V
A
S
Y
V
L
G
I
G
D
R
H
S
D
N
I
M
V
K
K
T
G
Q
L
F
H
I
D
F
G
H
I
L
G
N
F
K
S
K
F
G
I
K
R
E
R
V
P
F
I
L
T
Y
D
F
I
H
V
I
Q
Q
G
K
T
G
---
N
---
T
E
K
-----
F
G
R
F
R
Q
C
C
E
D
A
Y
L
I
L
R
R
H
G
N
L
F
I
T
L
F
A
L
M
L
T
A
G
L
P
E
L
T
S
V
K
D
I
Q
Y
L
K
D
S
L
A
L
G
K
S
E
E
E
A
L
K
Q
F
K
Q
K
F
D
E
A
L
-----------------