@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_14_0890: (2018-03-08 )
MRPNGEERPTVALSQNIMSVYEAINTLFYQERQLLLTAPAKYAARKYEDAAGHYLPYPGEEIAERYVVREVIGKGSFGTVLHCVDQKYHEAVAVKVIRSGPYFESQGWFEAQVVAHLNNDPALQNLVVQLRKVFLWKGHMVLVFEPLSFSLYRLITLTKYNGVSLDLTRKFAYQMIKVLLVLEQHQPPIIHCDLKPENVLLRDPSRSEVRVIDFGSACYQQQQKWSPPPAQVVLPSTSPSSSPGPPWDSVAEGPSGGVKPTAAADDDDSSAPQSPPKGPQQRHQATAGSTTASVDAALASGVAAPTAEGADTVEKASDAAPAAAAAAGTATGDNRRGDIIMPKYIQSRYYRSPEVILELGYTTAIDRWSLGCFLVEMHTGVPLFPGKNEGDMVAYFTSILGPLPDYMIAASPKRTQLYYTCHSEPSTKSGGGELAHGVATAGAGPAEDAPPGLTPMSSAPGHAMGSPFFLRAPRVEGEGAAAAAVPGSGSNSPPLSLEEILGVHKGGPRGCRAGQPGHDESAYEVFCDFIHKLLQYDPRKRVSCQQAIQHPFLEPIRALKSRSAAPPSAAPGTGGGNTEAGSAPPPPLPGPPQ
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80....-....90.........100.......110......-.120-.-.-..-...130.......140.......150.......160.......170.......180.......190.......200.----------------.-----------------------.-----------------....210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRPNGEER
P
T
V
A
L
S
Q
N
I
M
S
V
Y
E
A
I
N
T
L
F
Y
Q
E
R
Q
L
L
L
TA
P
A
K
Y
A
A
R
KYEDAAGHYLPYP
G
E
E
I
A
E
R
Y
V
V
R
E
V
IGKGS
F
G
T
V
L
H
C
V
D
-
Q
K
Y
H
E
-
A
V
A
V
K
V
I
RSGPYFESQG
W
F
E
A
Q
V
V
A
HLN-N
D
P
A
-
L
-
Q
-
N
L
-
V
V
Q
L
R
K
V
F
LWKG
H
M
V
L
V
FEPLS
F
S
L
Y
R
L
I
T
L
T
KYNGVS
L
D
L
T
R
K
F
A
Y
Q
M
I
K
V
L
L
V
L
EQHQP
P
I
I
H
C
DLKPE
N
V
L
LRD----------------P-----------------------S-----------------RS
E
V
R
V
I
DF
G
S
A
C
Y
Q
Q
Q
QKWSPPP
A
Q
V
V
L
PSTSPSSSPGPPW
D
S
VAEGPSGGVKPTAAADDDDSSAPQSPPKG
P
Q
Q
R
H
QATAGSTT
A
S
V
D
A
A
L
ASGVAAPTAEGA
D
T
V
E
KASDAAPAAAAAAGTATGDNRRGDII
M
P
K
Y
I
Q
S
R
YYR
S
P
E
V
I
L
ELGYTTAIDRWS
L
G
C
F
L
V
E
MHTGVPLFPGKNEG
D
M
V
A
Y
F
T
S
I
LGPLP
D
Y
MIAASPK
R
T
Q
L
Y
Y
T
CHSEPSTKSGGG
E
L
A
H
GVATAGAGPAEDAPPGLTPMSSAPGHAMGS
P
F
F
L
RAPRVEGEGA
A
A
AAVPGSGSNSPPL
S
L
E
E
I
L
G
VHKGGPRGCRAGQPGHD
E
S
A
Y
E
V
F
C
D
F
I
H
K
L
LQYDPRKR
V
S
C
Q
Q
A
I
QH
P
F
L
E
P
I
R
A
L
K
SRSAAPPSAAPGTGGGNTEAGSAPPPPLPGPPQ
22
HHSearch
88.49
46%
-146
- C1 -
-
4YLL
8
DYR1A_HUMAN
A:
[13-265]
-------------------------------------------
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
-
K
H
D
T
-
E
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
---------------------------------------------------------------------------------------------------------------------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
82.73
45%
-80
- C1 -
-
5LXC
8
DYRK2_HUMAN
A:
[62-299]
-------------------------------------------------
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
-
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
-
K
Q
D
K
-
D
N
T
-
M
N
-
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
----------------
Q
-----------------------
G
-----------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
---------------------------------------------------------------------------------------------------------------------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
81.52
46%
-80
- C1 -
-
4AZF
1
DYRK2_HUMAN
A:
[87-321]
-----------------------------------------------------
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
-
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
-
K
Q
D
K
-
D
N
T
-
M
N
-
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
----------------
Q
-----------------------
G
-----------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
---------------------------------------------------------------------------------------------------------------------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
81.47
46%
-91
- C1 -
-
4YU2
2
DYR1A_HUMAN
A:
[11-258]
-----------------------------------------
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
-
K
H
D
T
-
E
M
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
---------------------------------------------------------------------------------------------------------------------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
75.81
35%
-104
- C1 -
-
3LLT
1
?
A:
[27-273]
-------------------------------------------------------
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
-
I
D
N
K
K
-
Y
Y
A
V
K
V
V
R
N
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
-
N
D
D
I
-
N
-
N
-
N
N
-
I
V
K
Y
H
G
K
F
M
Y
Y
D
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
--
K
M
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
----------------
P
YF
E
K
S
L
I
T
V
R
R
VTDG
K
K
I
Q
I
Y
R
T
K
-----------------
S
T
G
I
K
L
I
D
F
G
C
A
T
F
K
S
D
Y
---------------------------------------------------------------------------------------------------------------------
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
H
M
E
H
L
A
M
M
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
74.50
37%
-41
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[9-254]
----------------------------------------------------------
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
-
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
-
T
T
D
P
N
S
-
T
-
F
R
-
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
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Y
D
F
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E
N
G
F
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P
F
R
L
D
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R
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M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
----------------
S
-----------------------
D
Y
T
E
A
Y
N
PKIK
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
---------------------------------------------------------------------------------------------------------------------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
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A
L
G
W
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Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
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F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
74.14
37%
-44
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[8-254]
---------------------------------------------------------
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
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V
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E
C
I
D
H
K
A
G
G
R
-
H
V
A
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N
V
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Y
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E
A
A
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I
Q
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H
L
N
-
T
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D
P
N
S
-
T
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F
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A
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Q
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V
N
F
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--
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
----------------
S
-----------------------
D
Y
T
E
A
Y
NR
D
E
R
T
L
I----
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
---------------------------------------------------------------------------------------------------------------------
H
S
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K
E
H
L
A
M
M
E
R
I
L
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P
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
73.73
32%
-42
* C1 *
-
2EU9
1
A:
[10-259]
------------------------------------------------------
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
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F
G
K
V
V
E
C
L
D
-
H
A
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R
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V
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K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
-
E
K
D
K
-
E
-
N
K
F
L
-
C
V
L
M
S
D
W
F
N
F
H
G
H
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A
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E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
LYNEHS
C
E
E
K
S
V
-----------------------
K
-----------------
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
---------------------------------------------------------------------------------------------------------------------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.05
40%
-88
- C1 -
-
4MQ2
3
DYR1A_HUMAN
A:
[28-226]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
71.39
40%
-95
- C1 -
-
3ANR
1
DYR1A_HUMAN
A:
[30-231]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.28
40%
-86
- C1 -
-
2VX3
4
DYR1A_HUMAN
A:
[49-245]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.07
40%
-91
- C1 -
-
5A3X
1
DYR1A_HUMAN
A:
[30-231]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
69.86
40%
-89
- C1 -
-
4YLJ
3
DYR1A_HUMAN
A:
[28-224]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
69.76
40%
-89
- C1 -
-
3ANQ
1
DYR1A_HUMAN
A:
[30-231]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.67
40%
-88
- C1 -
-
4NCT
1
DYR1A_HUMAN
A:
[30-231]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.79
40%
-89
- C1 -
-
5A54
1
DYR1A_HUMAN
A:
[30-231]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.71
40%
-89
- C1 -
-
2WO6
1
DYR1A_HUMAN
A:
[49-249]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
68.59
40%
-95
- C1 -
-
5AIK
1
DYR1A_HUMAN
A:
[49-248]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
68.19
40%
-90
- C1 -
-
5A4T
1
DYR1A_HUMAN
A:
[30-231]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
67.98
40%
-91
- C1 -
-
4MQ1
3
DYR1A_HUMAN
A:
[28-224]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.19
40%
-89
- C1 -
-
4YLK
10
DYR1A_HUMAN
A:
[28-230]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
-
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
66.63
40%
-91
- C1 -
-
4YLL
8
DYR1A_HUMAN
A:
[28-230]
----------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
---
K
-
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------
P
-----------------------
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
---
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
65.59
41%
-105
- C1 -
-
5LXD
2
DYRK2_HUMAN
A:
[59-237]
----------------------------------------------
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
-
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
-
K
Q
D
K
-
D
-
N
-
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
----------------
Q
-----------------------
G
-----------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
64.36
41%
-101
- C1 -
-
5LXC
6
DYRK2_HUMAN
A:
[59-237]
----------------------------------------------
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
-
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
-
K
Q
D
K
-
D
-
N
-
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
----------------
Q
-----------------------
G
-----------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------