@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_14_1380: (2018-03-08 )
MVSPHGRSTFAASILTTGTQLTTGNGTASTGGSAGLGANHNGACAFTPSSLSQDGNGGQSRAPRLASHLFLEDGSIPDISLPPATLQSPAVPDGQQHFGCSGGGGHVSVTALDQSRTPLCSAERRASLYDESSALAAVSLPADASRPTAANFVKGELIGKGSYGAVYRGMQRNNNRIIAMKEIRLPGVVEQQLRQPEKLAATAASPAGVSSCPVLPASNSVKGESALAKEVAAIKRELTLLKQLNHPNIVRYLNDEVVDGTLRIYMDYVSGGSVTAALKSYGSFEEPQAAALCFQLLQGLAYMHRRGIIHRDLKGDNLLLETSSQLKIADLGTARSICSSTTMTTNIVGTAYFMAPEVLQPNGAAAGTAADIWSVACCVIEMMTGKPPLSDLPNQFTVMMAIGGSATVPLDKYIPADNTWSSEVLDFVSQCLRANPAQRPTAVELLQHSWFAKFLNVVHVPSMSTPATLNSFLTPPAPPIERPFTLSPQRQMVSPICSPNLTAVLTPGYAGPQYSAGQPESRSSSRTSSRTSRERKGKRDKRVSARRHTRYSTSGATSATSRRSQESSQASTPQYSSSTRTRDGSAQSASLPRSHSHPGRQQGPTSKRRAHAHTPGHGLLKDDSRQSSSSEYAMPHHTCTPGSGSAGAGGGGDGSGDNKTKTVFLPAITHNGSVALSPCGYSLDMLRCSRSLKNSGSSREPVKACLHTTDAENKSRDLLHLGQCLSDHHQSFSRDLVDSSMQHGGVTKAGVESGLSTRGAGSHSMIDDLEGMGQRTLPPSISALPSTSCKNTRASEGAS
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.----.......290..--.....300...-....310.......320-.---.----.....330.......340.......350.......360-.......370.......380.......390-.......400.......410.......420.......430.......440---.........450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVSPHGRS
T
F
A
A
S
I
LTTG
T
Q
L
TTGNGTASTGGSAGLGANHNG
A
C
A
FT
P
S
S
LSQDGNGGQSR
A
P
R
L
A
S
H
L
F
LEDGSIPDISLPPATLQSPAVPDG
Q
Q
HFGCSGGG
G
H
V
S
V
T
A
LDQSRTPLC
S
A
E
R
R
A
S
LYDESS
A
L
A
A
V
SLPADASRPTAANFV
K
G
E
L
IGKGS
Y
G
A
V
Y
RGMQRNN
N
R
I
I
A
M
K
EIRLP
G
V
V
E
Q
Q
LRQ
P
E
K
L
A
ATAASPAGVSSCPVLPASNSVK
G
E
S
A
L
A
K
E
V
A
A
I
K
R
E
L
T
L
L
K
QLNH
P
N
I
V
R
Y
L
NDEVVD
G
T
L
R
I
Y
M
D
YVSGG
S
V
T
A
A
L
K
S-YG----SFEE
P
Q
A
A
A
L
C
F
--
Q
L
L
Q
G
L
A
Y
M
H
R-RGIIHRDLKGD
N
L
L
L
ET-S---S----Q
L
K
I
A
DLG
T
A
R
S
I
CSST
T
M
T
T
N
I
V
G
T
A
YFMAPEVLQPN-GAAAG
T
A
A
D
I
W
S
V
A
C
C
V
I
E
MMTGKPP
L
S
DL-PN
Q
F
T
V
M
M
A
IGGSATVPLDKYIPADNT
W
S
S
E
V
L
D
F
V
S
Q
C
L
RANPAQR
P
-----
T
A
V
E
L
L
Q
H
S
W
F
A
K
F
L
N
V
VHVPSMST
P
A
T
L
N
S
FLTPPAPPIERPFTLS
P
Q
R
Q
M
VSPICSPN
L
T
A
V
LTPGYAGPQYSAGQPESRSSSRTSSRT
S
R
E
RKGKRDKR
V
S
A
RRH
T
R
YSTSGATSATSRRSQESSQASTPQYSSSTRTRDGSAQSASLPRSHSHPGRQQGPTSKRRAHAHTPGHGLLKDDSRQSSSSEYAMPHHTCTPGSGSAGAGGGGDGSGDN
K
T
K
T
V
F
L
P
A
ITHNG
S
V
A
LSPCGY
S
L
D
M
L
R
C
S
R
S
L
KNSGSSR
E
P
V
K
A
C
L
HTTDAENK
S
R
D
L
L
H
L
G
Q
C
L
S
D
H
H
Q
S
F
S
R
D
L
V
D
S
S
M
QHGGV
T
K
A
G
V
E
SGLSTRGAGSH
S
M
I
D
D
L
E
G
MGQRTLPPSISALPSTSCKNTRASEGAS
37
HHSearch
92.10
31%
-121
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-350]
----------------------------------------------------------------------------------------------------------------------------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
----------------------------------------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
--
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
---
G
----
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
---
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
K
A
-
M
K
M
I
R
D
N
L
P
P
----
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
A
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
84.95
29%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
--------------------------------------
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
-
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
--
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
SKG
A
----
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
----
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
84.10
32%
-95
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-268]
----------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
----------------------------------------
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
-
T
G
----
P
L
S
E
L
Q
I
A
Y
V
S
R
--
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
-
N
---
G
----
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
R
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
-
H
P
M
R
A
L
F
L
M
T
K
S
N
F
Q
P
P
---
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
83.16
30%
-82
- C1 -
-
4QMV
3
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
82.80
30%
-80
- C1 -
-
4QML
2
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.46
30%
-80
- C1 -
-
4QMO
3
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
82.21
30%
-80
- C1 -
-
4QMN
1
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
82.03
30%
-78
- C1 -
-
4QMS
2
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
81.98
30%
-79
- C1 -
-
4QMP
2
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
81.65
30%
-78
- C1 -
-
4QMQ
3
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.98
30%
-79
- C1 -
-
4QMM
3
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
80.83
30%
-75
- C1 -
-
4QMU
1
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
80.66
30%
-78
- C1 -
-
4QMT
2
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
80.60
30%
-78
- C1 -
-
4QMY
2
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
80.23
30%
-76
- C1 -
-
4QMW
2
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
80.01
30%
-76
- C1 -
-
4QMX
1
STK24_HUMAN
A:
[31-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
---------------------------------------
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
--
G
----
P
L
D
E
T
Q
I
A
T
I
L
R
--
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
----
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--------
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
79.10
28%
-65
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[7-276]
----------------------------------------------------------------------------------------------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-------------------------------------
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
--
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
-
D
---
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
---
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
-
D
H
E
K
L
F
E
L
I
L
M
E
E
--------
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
74.71
26%
-61
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[23-294]
----------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
-----------------------------------
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
-
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
--
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
ENS
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
-
K
E
R
L
--
F
E
G
I
I
K
G
K
Y
K
M
---
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
73.87
26%
-60
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[10-278]
----------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
----------------------------------
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
--
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
---
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
----
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
72.85
26%
-60
* C1 *
-
3C0G
1
CSKP_HUMAN
B:
[23-294]
----------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
-----------------------------------
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
-
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
--
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
ENS
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
-
K
E
R
L
--
F
E
G
I
I
K
G
K
Y
K
M
---
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
71.10
33%
-19
- C1 -
-
4BIC
2
M3K5_HUMAN
A:
[26-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------------
P
E
------
S
Q
P
---------------------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
----
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
-
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
---
E
I
P
--
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
----
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.19
33%
-18
- C1 -
-
4BIE
2
M3K5_HUMAN
A:
[26-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------------
P
E
------------------------------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
----
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
-
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
---
E
I
P
--
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
----
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.87
33%
-15
- C1 -
-
2CLQ
1
M3K5_HUMAN
A:
[29-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------------
P
E
R
-
D
---
S
Q
P
---------------------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
----
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
-
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
---
E
I
P
--
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.42
33%
-7
- C1 -
-
4BID
1
M3K5_HUMAN
A:
[26-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------------
P
E
------------------------------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
----
V
L
K
I
S
D
F
G
T
S
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
-
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
---
E
I
P
--
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
----
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
63.10
33%
-17
- C1 -
-
5V24
1
M3K5_HUMAN
A:
[16-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------------
P
E
R
-
D
S
----
P
---------------------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
----
V
L
K
I
S
D
F
G
T
S
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
------
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
---
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
---
E
I
P
--
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------