@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_15_0810: (2018-03-08 )
MNFLGGSLRSGGGHRRDKGFSAKNKVQQYHGDGSESIILVGRPFRVLQKISDVPPPYMVGRQRSTKYGEGGSSYVYLVENTNHLPEFPRHLALKRSFFGVDQVTEAHKEVDIVSHIEDKNIVRVYHSEISRSEGRLGVSIAMEYCSNNLYRRIRSSAGTGPGTRLTEAEICHVMFAVTSAVGYLHAQQPPITHRDIRPENILINNKHAGPTAYKLTNFGNATTEAYQCETREEANMAIADIQMHTNPAFRAPEMADPWSKKRICEKTDMWAMGVLLYYMMYLCLPFDPSTTIGKENWVVTFPSQAMTSYTTSLRVMAEHLLDPDPCSRWDVFALTNYMRFDEDCSRHLGTFCFTKTEWPEGWEEQDVKVLGRAPPPKAPPVSYNEPGHEQLDSRGLSGQERVYGHVNRHQPPDDRGNGRDNAVVDSDAVQEAMIVLGGDPADDDPAVAECRHQIIMEQQEAWRRAKAAAGLRDSPPMEPQESSAAPAPTRANNGAERDVFDDLFASASPTVFPTSQAPPVMSPSAPPATHQPPEKDAFSASDLFSTSAPQLHPSYPMMSTYGQAPQQMAMGGWGSGAPVMGGGGYPMQQPQNQQQASWGYGVSNANNYAPPPPPPQQQQQPFTNFLAPVPGQQPSQQPETSQPPTARATAKRDPFADLFN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60....---.---...70........80........90........-100----.-------......-.-.110.....-..-120.....-..-130.--....-...---140...-.-..-.150.......160.......170.......180.......190.......200...-....210.......220...----....230.......240.......250.......260.......270.......280.......-290.---..----.----..---------------------.-------------------300------.........310.......320.......330.......340.....-----..350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNFLGGSLRSGGGHRRDKGFSA
K
N
K
V
Q
Q
YHGDGS
E
S
I
I
L
VG
R
P
F
R
V
L
Q
K
I
SDVPPPYMVGRQRST---K---YGEGG
S
S
Y
V
Y
L
VENTNHL
P
E
F
P
R
H
L
A
L
K
R
S
FF
G
-
V
------
D
-------
Q
V
T
E
A
H
-
K
-
E
V
D
I
V
S
HIE-DK-NI
V
R
V
Y
H
S
-EI-SR-S--EGR
L
-
G
V
S
---
I
A
M
E
Y
C
-
S
-
N
N
-
L
Y
R
R
I
R
S
SAGTGPGTRL
T
E
A
E
I
C
H
V
M
F
A
V
T
S
A
V
G
Y
LHAQQPPITHRDIRPE
N
I
L
I
NN-KHAGP
T
A
Y
K
L
TNFGNAT
T
E
A
----
Y
QCETREEA
N
M
A
I
A
D
I
Q
MHTNPAFRAPEMADPWSKKRICEKT
D
M
W
A
M
G
V
L
L
Y
Y
M
M
Y
L
CLPFDPS-TTIG---KE----
N
----
W
V
---------------------
V
-------------------T--------FP
S
Q
A
M
T
S
Y
T
T
S
L
R
V
M
A
E
HLLDPDPCSRW
D
V
F
A
L
T
N
Y
M
R
F
D
E
D
C
S
R
H
-----
L
G
T
F
C
F
TKTEWPEGWEE
Q
D
V
K
VLGRAPPPKAPPVSYNEP
G
H
E
Q
L
D
SRGLSG
Q
E
R
V
Y
G
HVNRHQPPDDRGNGRDNAVV
D
S
D
A
V
Q
E
A
M
I
V
LGGDPADDD
P
A
V
A
E
C
R
H
Q
I
I
M
E
Q
Q
E
A
W
R
R
A
K
A
AAGLRDSPPMEPQESSAAPAPTRANNGAE
R
D
V
F
D
D
L
F
ASASPTVFPTSQAPPVMSPSAPPATHQPPEKDAF
S
A
S
DLFSTSAPQLHPSYP
M
M
S
T
YGQ
A
P
Q
Q
M
AMGGWGSGAPVMGGGGYPMQQPQNQQQASWGYGVSNANNYAPPPPP
P
Q
Q
QQQ
P
F
T
N
FLAPVPGQQPSQQPETSQPPTARATAKRDP
F
A
D
LFN
7
PsiBlast_PDB
78.04
30%
-11
- C1 -
-
5I3O
1
BMP2K_HUMAN
A:
[3-273]
--------------------------------------------------------
F
A
V
G
R
H
Q
V
T
L
E
E
S
---
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
-----
R
C
A
L
K
R
M
Y
V
N
N
M
------
P
-------
D
L
N
V
C
K
-
R
-
E
I
T
I
M
K
E
L
S
G
H
K
-
N
I
V
G
Y
L
D
C
-
A
V
N
S
I
-
S
--
D
N
V
W
-
E
V
L
---
I
L
M
E
Y
C
R
A
-
G
Q
-
V
V
N
Q
M
N
K
K
L
Q
T
G
----
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
-
G
----
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
----
L
N
-
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
---
D
G
----
N
----
F
------------------------------------------
T
--------
I
P
D
N
--
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.62
30%
-13
- C1 -
-
5I3R
1
BMP2K_HUMAN
A:
[3-273]
--------------------------------------------------------
F
A
V
G
R
H
Q
V
T
L
E
E
S
---
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
-----
R
C
A
L
K
R
M
Y
V
N
N
M
------
P
-------
D
L
N
V
C
K
-
R
-
E
I
T
I
M
K
E
L
S
G
H
K
-
N
I
V
G
Y
L
D
C
-
A
V
N
S
I
-
S
--
D
N
V
W
-
E
V
L
---
I
L
M
E
Y
C
R
A
-
G
Q
-
V
V
N
Q
M
N
K
K
L
Q
T
G
----
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
-
G
----
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
----
L
N
-
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
---
D
G
----
N
----
F
------------------------------------------
T
--------
I
P
D
N
--
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
77.10
31%
-36
- C1 -
-
5TE0
10
AAK1_HUMAN
A:
[24-288]
---------------------------------------------------------------
D
E
---
V
---
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
-----
M
K
C
A
L
K
R
M
F
V
N
-
N
------
E
H
------
D
L
Q
V
C
K
-
R
-
E
I
Q
I
M
R
D
L
S
G
H
K
-
N
I
V
G
Y
I
D
S
-
S
I
-
N
N
-
V
----
V
W
-
E
V
L
---
I
L
M
D
F
C
-
R
-
G
G
Q
V
V
N
L
M
N
Q
R
L
----
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
-
R
G
----
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
----
Q
N
P
Q
T
E
G
-
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
G
E
S
-
Q
V
A
----
I
C
----
D
----
G
N
---------------------
F
-------------------
T
--------
I
P
--
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.07
30%
-13
- C1 -
-
4W9W
7
BMP2K_HUMAN
A:
[6-276]
--------------------------------------------------------
F
A
V
G
R
H
Q
V
T
L
E
E
S
---
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
-----
R
C
A
L
K
R
M
Y
V
N
N
M
------
P
-------
D
L
N
V
C
K
-
R
-
E
I
T
I
M
K
E
L
S
G
H
K
-
N
I
V
G
Y
L
D
C
-
A
V
N
S
I
-
S
--
D
N
V
W
-
E
V
L
---
I
L
M
E
Y
C
R
A
-
G
Q
-
V
V
N
Q
M
N
K
K
L
Q
T
G
----
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
-
G
----
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
----
L
N
-
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
---
D
G
----
N
----
F
------------------------------------------
T
--------
I
P
D
N
--
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.00
30%
-12
- C1 -
-
5IKW
1
BMP2K_HUMAN
A:
[9-279]
--------------------------------------------------------
F
A
V
G
R
H
Q
V
T
L
E
E
S
---
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
-----
R
C
A
L
K
R
M
Y
V
N
N
M
------
P
-------
D
L
N
V
C
K
-
R
-
E
I
T
I
M
K
E
L
S
G
H
K
-
N
I
V
G
Y
L
D
C
-
A
V
N
S
I
-
S
--
D
N
V
W
-
E
V
L
---
I
L
M
E
Y
C
R
A
-
G
Q
-
V
V
N
Q
M
N
K
K
L
Q
T
G
----
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
-
G
----
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
----
L
N
-
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
---
D
G
----
N
----
F
------------------------------------------
T
--------
I
P
D
N
--
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.08
30%
-25
- C1 -
-
4W9X
3
BMP2K_HUMAN
A:
[9-279]
--------------------------------------------------------
F
A
V
G
R
H
Q
V
T
L
EE
S
---
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
-----
R
C
A
L
K
R
M
Y
V
N
N
M
------
P
-------
D
L
N
V
C
K
-
R
-
E
I
T
I
M
K
E
L
S
G
H
K
-
N
I
V
G
Y
L
D
C
-
A
V
N
S
I
-
S
-----
W
-
E
V
L
---
I
L
M
E
Y
C
R
A
-
G
Q
-
V
V
N
Q
M
N
K
K
-
Q
T
G
----
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
-
G
----
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
----
L
N
-
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
---
D
G
----
N
----
F
------------------------------------------
T
--------
I
P
D
N
--
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
73.74
31%
-7
- C1 -
-
5TE0
10
AAK1_HUMAN
A:
[14-285]
--------------------------------------------------------
F
G
I
G
R
Q
Q
V
T
---
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
M
-----
K
C
A
L
K
R
M
F
V
N
-
N
------
E
-------
H
D
L
Q
V
C
-
K
R
E
I
Q
I
M
R
D
L
S
G
H
K
-
N
I
V
G
Y
I
D
S
-
S
I
-
N
N
V------
V
W
E
V
L
---
I
L
M
D
F
C
-
R
-
G
G
----
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
-
R
----
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
-----
F
Q
N
P
Q
T
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
G
E
S
Q
V
A
I
C
---
D
G
----
N
----
F
------------------------------------------
T
--------
I
P
D
N
S
--
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.57
31%
7
- C1 -
-
5L4Q
2
AAK1_HUMAN
A:
[13-284]
--------------------------------------------------------
F
G
I
G
R
Q
Q
V
T
---
V
DEV
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
M
-----
K
C
A
L
K
R
M
F
V
N
-
N
------
E
-------
H
D
L
Q
V
C
-
K
R
E
I
Q
I
M
R
D
L
S
G
H
K
-
N
I
V
G
Y
I
D
S
-
S
I
-
N
N
V
S
--
S
G
D
V
W
E
V
L
---
I
L
M
D
F
C
-
R
-
G
G
----
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
-
R
----
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
-----
F
Q
N
P
Q
T
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
-----------------
N
----
F
------------------------------------------
T
--------
I
P
D
N
S
--
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.00
31%
1
- C1 -
-
4WSQ
2
AAK1_HUMAN
A:
[11-282]
--------------------------------------------------------
F
G
I
G
R
Q
Q
V
T
---
V
DEV
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
M
K
-----
C
A
L
K
R
M
F
V
N
-
N
------
E
-------
H
D
L
Q
V
C
-
K
R
E
I
Q
I
M
R
D
L
S
G
H
K
-
N
I
V
G
Y
I
D
S
-
S
I
-
N
N
V
S
--
S
G
D
V
W
E
V
L
---
I
L
M
D
F
C
-
R
-
G
G
----
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
-
R
----
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
-----
F
Q
N
P
Q
T
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
G
E
S
Q
V
A
I
C
---
D
G
----
N
----
F
------------------------------------------
T
--------
I
P
D
N
--
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
62.83
20%
-23
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[58-342]
--------------------------------------------------------------
D
T
K
---
V
---
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
----
E
L
V
A
I
K
K
V
L
Q
D
-
K
----------------
R
F
K
N
-
R
-
E
L
Q
I
M
R
K
L
D
-
H
C
-
N
I
V
R
L
R
Y
F
-
F
Y
-
S
S
-
G
EK
K
D
E
V
-
Y
L
N
---
L
V
L
D
Y
V
-
P
-
E
T
-
V
Y
R
V
A
R
H
Y
S
R
--
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
--
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
-
D
T
---
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
----
R
G
E
----------
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
--
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
-
S
G
V
D
---
Q
L
----
V
----
E
I
I
K
V
LGTPT
R
E
Q
I
R
E
M
NPNYTE
F
-------------------
K
FPQIKAHP
W
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
62.50
25%
-99
- C1 -
-
3PWY
1
PDPK1_HUMAN
A:
[41-276]
-------------------------------------------------------------------------
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
------
N
-------
K
V
P
Y
V
T
-
R
-
E
R
D
V
M
S
R
L
D
-
H
P
-
F
F
V
K
L
Y
F
T
-
F
Q
-
D
D
-
E
--
K
L
Y
F
-
G
L
S
---
Y
A
K
N
G
C
-
L
-
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
--
C
T
R
F
Y
T
A
E
I
-------
V
S
A
L
E
Y
L
H
G
K
--
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
-
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----
P
---------
S
F
V
G
T
A
Q
------
Y
V
S
P
E
L
---
L
T
E
K
S
A
S
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
-
N
E
Y
L
---
I
F
----
Q
----
K
I
---------------------
I
-------------------
K
--------
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
61.03
19%
-6
- C1 -
-
1KOB
1
?
A:
[23-374]
------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
---
E
---
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
----
P
------
L
-------
D
K
Y
T
V
K
-
N
-
E
I
S
I
M
N
Q
L
H
-
H
P
-
K
L
I
N
L
H
D
A
-
F
E
-
D
K
-
Y
-------
E
M
V
---
L
I
L
E
F
L
-
S
G
G
E
-
L
F
D
R
I
-----
A
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
--
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
-
K
K
A
S
S
--
V
K
I
I
D
F
G
L
A
T
K
--------
L
N
P
D
E
I
V
K
V
T
T
A
------
T
A
E
F
A
A
P
E
I
V
---
D
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
-
D
D
L
E
---
T
L
----
Q
----
N
V
---------------------
K
R
C
D
W
---------------
E
--------
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
TSRIP
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
60.98
27%
-9
- C1 -
-
4C57
5
GAK_HUMAN
A:
[36-295]
-------------------------------------------------------------------------
A
E
G
G
F
A
F
V
Y
E
A
Q
D
V
G
S
----
G
R
E
Y
A
L
K
R
L
L
S
N
-
E
------
E
-------
E
K
N
R
A
I
I
Q
-
E
V
C
F
M
K
K
L
S
-
G
H
P
N
I
V
Q
F
C
S
A
A
S
I
-
G
K
-
E
--
E
S
D
T
-
G
Q
A
E
F
L
L
L
T
E
L
C
-
K
-
G
Q
-
L
V
E
F
L
K
K
M
E
S
R
G
P
---
L
S
C
D
T
V
L
K
I
F
Y
Q
T
C
R
A
V
Q
H
M
H
R
Q
K
P
P
I
I
H
R
D
L
K
V
E
N
L
L
L
S
N
-
Q
----
G
T
I
K
L
C
D
F
G
S
A
T
T
I
S
H
Y
P
D
Y
S
W
S
A
Q
R
R
A
-
L
V
E
E
E
I
T
R
N
T
T
P
M
Y
R
T
P
E
I
I
D
L
Y
S
N
F
P
I
G
E
K
Q
D
I
W
A
L
G
C
I
L
Y
L
L
C
F
R
Q
H
P
F
E
D
G
-
A
K
L
R
---
I
V
----
N
----
G
K
---------------------
Y
-------------------
S
--------
I
P
P
H
D
-
T
Q
Y
T
V
-
F
H
S
L
I
R
A
M
L
Q
V
N
P
E
E
R
L
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
60.97
21%
0
- C- -
-
3EB0
3
?
A:
[12-344]
---------------------------------------------------------------
G
K
---
T
---
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
E
S
G
----
K
R
F
A
L
K
K
V
L
Q
D
-
P
----------------
R
Y
K
N
-
R
-
E
L
D
I
M
K
V
L
D
-
H
V
-
N
I
I
K
L
V
D
Y
-
F
Y
-
T
T
------
N
K
-
Y
L
N
---
V
I
M
E
Y
V
-
P
-
D
T
-
L
H
K
V
L
K
S
F
I
R
--
S
G
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
--
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
S
K
D
N
----
T
L
K
L
C
D
F
G
S
A
K
K
L
I
----
P
S
E
----------
P
S
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
--
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
G
K
P
L
F
S
G
E
-
T
S
I
D
---
Q
L
----
V
----
R
I
---------------------
I
Q
IMGTP
T
K
E
Q
M
I
R
MNPHYV
R
F
P
T
L
K
A
K
D
W
R
K
I
L
P
E
G
T
P
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
60.42
24%
-43
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[27-280]
---------------------------------------------------------------
A
E
---
D
---
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
----
K
T
Y
M
A
K
F
V
K
V
K
-
G
------
T
-------
D
Q
V
L
V
K
-
K
-
E
I
S
I
L
N
I
A
R
-
H
R
-
N
I
L
H
L
H
E
S
-
F
E
-
S
-------
M
E
-
E
L
V
---
M
I
F
E
F
I
-
S
-
G
L
D
I
F
E
R
I
N
T
S
-----
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
--
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
-
R
R
S
--
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
----
P
G
D
N
----------
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
---
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
-
T
N
Q
Q
---
I
I
E
N
I
M
N
----
A
E
---------------------
Y
-------------------
T
--------
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
59.62
20%
-20
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
--------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
--------
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
------
K
T
Y
M
A
K
F
V
K
V
K
-
G
------
T
-------
D
Q
V
L
V
K
-
K
-
E
I
S
I
L
N
I
A
R
-
H
R
-
N
I
L
H
L
H
E
S
-
F
E
-
S
M
-
E
-------
E
L
V
---
M
I
F
E
F
I
-
S
G
L
D
-
I
F
E
R
I
-----
N
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
-
R
R
S
S
T
--
I
K
I
I
E
F
G
Q
A
R
Q
L
K
----
P
G
D
N
F
R
L
L
F
T
----------
A
P
E
Y
Y
A
P
E
V
H
Q
---
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
-
T
N
Q
Q
---
I
I
----
E
----
N
I
---------------------
M
N
AEY---------------
T
--------
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
-----------
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
59.10
22%
-2
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[16-277]
---------------------------------------------------------------
G
E
---
E
---
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
I
K
K
R
-
R
------
T
KSSRRGV
S
R
E
D
I
E
-
R
-
E
V
S
I
L
K
E
I
Q
-
H
P
-
N
V
I
T
L
H
E
V
-
Y
E
-
N
-------
K
T
-
D
V
I
---
L
I
L
E
L
V
-
A
-
G
G
E
L
F
D
F
L
A
E
K
------
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
----
F
G
N
E
----------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
---
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
---
T
L
----
A
N
V
S
A
V
N
---------------------
Y
-------------------
E
--------
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
58.24
23%
-32
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[29-292]
---------------------------------------------------------------
C
E
---
V
---
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
----
G
Q
Q
F
A
V
K
I
V
D
V
A
-
K
F
T
S
SPG
L
-------
S
T
E
D
L
K
-
R
-
E
A
S
I
C
H
M
L
K
-
H
P
-
H
I
V
E
L
L
E
T
-
Y
S
-
S
-------
D
G
-
M
L
Y
---
M
V
F
E
F
M
-
D
-
G
A
D
L
C
F
E
I
V
K
R
A
D
--
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
--
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
E
N
-
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
----
E
S
G
L
---------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
---
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
-
K
E
R
L
F
E
G
I
I
----
K
----
G
K
---------------------
Y
-------------------
K
--------
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
57.19
22%
-14
- C1 -
-
1KOB
1
?
A:
[56-310]
---------------------------------------------------------------
L
E
---
E
---
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
----
G
R
V
F
V
A
K
F
I
N
T
P
-
Y
------
P
L
------
D
K
Y
T
V
K
-
N
-
E
I
S
I
M
N
Q
L
H
-
H
P
-
K
L
I
N
L
H
D
A
-
F
E
-
D
-------
K
Y
-
E
M
V
---
L
I
L
E
F
L
-
S
-
G
G
E
L
F
D
R
I
A
A
E
-----
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
--
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
-
K
K
A
--
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
----
P
D
E
I
----------
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
---
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
-
D
D
L
E
---
T
L
----
Q
N
V
K
R
C
D
---------------------
W
-------------------
E
--------
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
56.45
23%
-39
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[29-292]
---------------------------------------------------------------
C
E
---
V
---
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
----
G
Q
Q
F
A
V
K
I
V
D
V
A
-
K
F
T
S
SPG
L
-------
S
T
E
D
L
K
-
R
-
E
A
S
I
C
H
M
L
K
-
H
P
-
H
I
V
E
L
L
E
T
-
Y
S
-
S
-------
D
G
-
M
L
Y
---
M
V
F
E
F
M
-
D
-
G
A
D
L
C
F
E
I
V
K
R
A
D
--
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
--
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
E
N
-
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
----
E
S
G
L
---------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
---
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
-
K
E
R
L
F
E
G
I
I
----
K
----
G
K
---------------------
Y
-------------------
K
--------
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------