@TOME V2.3
(Mar 2018)
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Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
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3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
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Structural Clustering:
Cluster Num
3D-Jury Struct. Score
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Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
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Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
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Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_15_1180: (2018-03-08 )
MDPAGRRLSGEQQQQQQPADRAKADADRGTVDMLPPLRTEASPFEQASAITNRSSAASAPLSVAVKVIPTLAAAMSSLRAGDDNDGGGENEGEEEPFLTNGSIALAEFTSLLKPAENNSILKEHIIHLLRDVDAEETLMRIARALEAQGTNETPVNVSATTCTGSSRDVASYTNASQSTVASMSTMQRRRSSAVSRRDATSLETLAGLSFLHSRRGATSPSAQESPSSAQPSEDVAPYNRSTRGLVGPLDTSFNSRSSLGTREEEQRQSKQQDDPLSAFMAASASQLSDATPTLRESPGLPTGSQCRGRRVAVSAAPCMAPPMIGEDSPATALPPLRVVPKTSAEEQQLRRLLRRCHSFSSLEADTLESVLKAMDKEVHAAGAAILEQGQATTEKLYLVGEGTCEAIKNGKSLGPLQPGGTFGELELMYKQAMCAATVRCVTRCVLYTLDEASYHRAVMTSALQKRRKFEKLTMSVPFLRCLPDFERMKIAEALETRVYQRGKTIIRFGSPGNYMHFIIEGEVKVVGRNSGRRVEVVRLRDGDVVGELEFLFNHLTVADVVATSREVRTACISREHFELIIGPIQDRLKEFVATSSTYEKYYVAEVADESVRTELNRIESSRKHRRVASRDQRTAIGGIDPHGEVLLSAPLPLLHGKCDTAGKAGGVSGVVANSDSAAGNGANAQGQRRAAARGSAELPKAMLRFPFAPITGKDVAVLALREDGLIMYWNSVLERLTSYSAGEAVGQNIYSFLLSEREQQCMYKAVNAARNYAGEAEAFLKRPSTKSIQFTLARSDGLTKTTVRLTIVPPVVSAGGNAAEVVLGFGEEVKEGPQKMLEQPQWLSGQIRAILADGTQTFEERLECIAETLNNFESTYRAMTVSTERLRVVNIRQMMGHILMDFGSECVSRGISVRQRFEGLPSERAYLDANLLPECLRYAMKLCLKYSDPGGSIITIMITVTEKNGLEFLVINFNLTGDGMPKAIAQFFDSPLKKHGDSVTTMSVDDDSGDGSGDDSDNDAEASMALRSTLQPRLRRKLRRVQRAVEDQGGTLRMLRNPQDSNIAFLIPFMPASEQDAENASIEESLSTLADSAGAGQLASLAGMSSGVGPPTSVAAAAAAFSVSLVNTPAGESSGLSNMSVAGTVATVSGQPNFSYTTCLAEDTPTHRIMLSSFLWERHHAVLTAFTFEDIVGLVGVADILIIDLQQSAITFLHERDPITRLREMLRHMAVIITSTNFDLVSSDTYAAAGFITLKKPCTPVQAMKAIRRAEEKSAVVKLERLRIEQTRETLARNSRGAWRHGALLGKGSSGEVYEAYDVLTGGKMAVKEMRLGNNDAKIEQFVQEISTMCNLQHPNIIHYFYCEESKEQKVIRVFMEFAGGGTLQSLLKTKGRLEYAELRALLRDVVEGLAYIHSQHYVHGDIKTANVLLSNDGKGKIGDFGTARTVNEGELLYVMQGSPLYMSPECMSAGEEDEDGNKIGYSFPSDIWSLGCVAMEMATNKPPFAHIKTIKGPAGLTTFITSLTDVPDLSPLFKCHPSIVEFVSACLNPDPSQRATAQDLLQMSLFSDSTHSDRNSAVMALKRAQLLHVLNKFVAFQEPEEAEKLEKRRNRLKVSRLASDFFSSRSSSSDNASEPMSTVFLNAAPAAEVEEATREKRRPGAAVTTAAAATAAVAAGNEDESDKDVTRRSGTVALAAGGASESPDGARPAGASAGAPLVNTVTSTDGSLNQAASTFTRYLRKWDFSTSSSSSSSQLSANSKAMTAAGGEGAHRDPVTGVAGGNDEAEPDARNPQTEGAYDLSPTPKKRSKTRSRPRATLTPPMRKPSHQRCCPDSTTTTTNSAEKDFFATSSDNSSSGRALNEADARSEAPAHQGGTARLTGTATTARNGPRPTGSEAVGYTPSFPGRRRNVRLDEAGNIVPFDRLSSMMSVAALLNNKGEQHGDDASAEGSPGVAAAAATEATAASRAPFPALGDANDHVLSPSSAAGLANASFTQPPGNYSFFGFNRNISFMGTNMDEVLNSAANDFLSNLAANWHTSNAACVETASSAGSMVQLPSRTFLRAEGSGSGRSHATLSSNREGECRTDRVVGVASPLAVTGQSEDRGDVPKTPSRRRGGAISRSPSARSPLEARGPGEPASIEGGNSGVQHGGTTLPLPQLPPPKPLSTGAAPTAASRSTHPVLSQLGSASYTSDDGTTSMTPRGDSVPLVGAAASSHRQRRARPPITNQSFFVVEDGSSAPLFSPHTGVTKSTGSMAGGPVSASRVSLATWSSVASADGSVTGGVAGETSSSTLLQQNYANVAVVAPAPVFPTFSTSSARAVWQQRRRHVAGGGRGGVGGGNMSNIHLTAPPSNEGSVYLMVADEQQGDGQRWRAAGASVSREGNDGDDDDLTSAAFGSMRSGFSRRSSAQSTSNLTAETLSATHEPVSERRPARSGDAAASASEGRRGAEVGDALPFSNLASEADSMVFTYLQRIDASLQDVLSQLQVRRRQCRRKSGGSITGVQDGFDHAPSSTPITTVQATPPQSATQLTTLQSSLSSALPSPASANSTSEVATTVTVSPQHHRSTGVSTSPAKLPRPLSSCTTPVTISQSRQGKPNPLSMRASPPLSKQCSNPRWPTEDEAEAEGDPVNHDATVWFDTPLSPSSSGHRASSGCDDVNVEVLLRKMLWRVSLLLDEVSSFSPRGPATASVARPP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520....--...530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360........1370......1380......1390-----.-..---......1400......1410......1420......1430...-..----...1440......1450---....-.....1460......1470......1480......1490......1500......1510......1520.-..-....1530-.........1540......1550.........1560......1570-.........1580......1590----........1600......-1610......1620......1630......---------1640------.......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780..--....1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620......2630......2640......2650......2660......2670......2680......2690.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDPAGRRLS
G
E
Q
Q
Q
Q
QQPADRAKADADRGTVDMLPPLRTEASP
F
E
Q
A
S
A
ITNRSSAASA
P
L
S
V
A
V
K
V
I
P
T
L
A
A
A
M
S
S
LRAGDDNDGGGENEGEEEPFLTNGS
I
A
L
A
E
F
T
S
L
LKPAEN
N
S
I
L
K
E
H
I
I
H
L
L
RDV
D
A
E
E
T
L
M
R
I
A
R
A
L
EAQGTNET
P
V
N
V
S
A
T
TCTGSSRD
V
A
S
YTNA
S
Q
S
T
V
A
S
M
S
T
M
Q
R
R
R
S
S
AVSRRDA
T
S
L
E
T
L
A
G
L
S
F
L
H
SRRGATSPSAQESPSSAQPSEDVAPYNRSTRGLVGPLDTSFNSRSSLG
T
R
E
E
E
Q
R
QSKQQDD
P
L
S
A
F
M
A
A
S
A
S
QLSDATPTLRESPGLPTGSQCRG
R
R
V
A
VSAAPCMAPPMIGEDSPATALPP
L
R
VVPKTS
A
E
E
Q
Q
L
R
R
L
L
R
R
C
HSFSSL
E
A
D
T
L
E
S
V
L
K
A
M
D
K
E
V
H
A
A
G
A
A
I
L
EQGQAT
T
E
K
L
Y
L
V
GEG
T
C
E
A
I
KNGKSLGPLQPGGT
F
G
E
L
E
L
M
Y
K
Q
A
M
C
A
A
T
V
R
C
V
T
R
C
V
L
Y
TLDE
A
S
Y
H
R
A
V
M
T
S
A
L
Q
K
R
R
K
F
E
K
L
T
MS
V
P
F
L
R
CLP
D
F
E
R
M
K
I
A
E
A
L
E
T
R
V
Y
QRG
K
T
I
I
R
FGSPG
N
Y
M
H
F
I
I
EG
E
V
K
V
V
--GRNSG
R
R
V
E
V
V
R
LRDGD
V
V
G
E
L
E
F
L
F
NH
L
T
V
A
D
V
VAT
S
R
E
V
R
T
A
C
IS
R
E
H
F
E
L
I
I
G
P
I
Q
D
R
L
K
E
F
V
ATSST
Y
E
K
Y
Y
V
A
E
VA
D
E
S
V
R
T
E
L
N
R
I
E
S
S
R
K
H
R
R
V
ASRDQRTAIGGIDPHG
E
V
L
LSAPL
P
L
LHGKCDTAGKAGG
V
S
G
V
VANSDSAAGNGANAQ
G
Q
R
R
AAARGS
A
E
L
P
K
A
M
L
RFPFAPITGK
D
V
A
V
L
A
LRED
G
L
I
M
Y
W
N
S
V
L
E
R
L
TSYSA
G
E
A
V
G
Q
N
I
Y
S
F
L
L
S
E
R
E
Q
Q
C
M
Y
K
A
V
N
A
A
RNYAG
E
A
E
A
F
L
KRPSTK
S
I
Q
F
T
L
ARSDGL
T
K
T
T
V
R
L
T
IVPPVVSAGG
N
A
A
E
V
V
LGF
G
E
E
V
K
E
G
P
Q
K
M
LEQPQWLS
G
Q
I
R
A
ILAD
G
T
Q
T
F
E
E
R
L
E
C
I
A
E
T
L
N
N
F
E
S
T
Y
R
A
M
T
VST
E
R
L
R
V
V
N
I
R
Q
M
M
G
H
I
L
M
D
F
G
S
E
C
V
S
R
G
I
S
V
R
Q
R
F
EGLPSERAY
L
D
A
N
L
L
P
E
C
L
R
Y
A
M
K
L
C
LKYSDPGG
S
I
I
T
I
M
I
T
V
TEKN
G
L
E
F
L
V
I
N
F
N
LTGDG
M
P
K
A
I
A
Q
F
F
D
S
P
L
K
KHGDS
V
T
T
M
S
VDDDSGDGSGDDSDN
D
A
E
A
S
M
A
L
R
S
T
L
Q
P
R
L
R
R
K
L
R
R
V
Q
R
A
V
EDQG
G
T
L
R
M
LRNPQDS
N
I
A
F
L
I
PFMPASEQDAEN
A
S
I
E
E
S
L
S
T
L
ADSAGA
G
Q
L
A
S
L
A
GMSSGVGP
P
T
S
V
A
A
A
A
A
A
F
S
V
S
L
V
NTPAGESSGLSN
M
S
V
A
G
T
V
A
TVSGQPNF
S
Y
T
T
CLAEDTPT
H
R
I
M
L
S
S
F
L
W
E
R
H
H
A
V
L
T
A
F
T
F
E
D
I
V
G
L
V
G
V
A
D
I
L
I
I
D
L
Q
Q
S
A
I
T
F
L
HER
D
P
I
T
R
L
R
E
M
L
R
H
M
A
V
I
I
TSTN
F
D
L
VSSDT
Y
A
A
A
G
F
I
T
LKKPC
T
P
V
Q
A
M
K
A
I
R
R
A
E
E
K
S
A
V
V
K
L
E
R
L
R
I
E
Q
T
R
E
T
L
A
RNSRGAWRH
G
A
L
LGKGSSG
E
V
Y
E
A
Y
DVLTGG
K
M
A
V
K
E
MRLGN
N
D
A
K
I
E
Q
F
V
Q
E
I
S
T
M
CNLQHP
N
I
I
H
Y
F
--YCEESK
E
Q
K
V
I
R
V
F
M
E
FAGG
G
T
L
Q
S
L
L
K
T--------K-GR---
L
E
Y
A
E
L
R
A
L
L
R
D
V
V
E
G
L
A
Y
I
H
SQ
H
Y
VHGD
I
K
T
A
N
V
L
L--SNDG-KG----KIGDFGT
A
R
TVNEG------
E
L
L
Y
-
V
MQGS
P
L
Y
M
S
P
E
C
MSAGEEDEDG
N
K
IGYSF
P
S
D
I
W
S
L
G
C
V
A
M
E
MATNKPP
F
A
H
I
K
TIKGPA
G
L
T
T
F
-
I
T
S
-LT-DVPDL----
S
P
L
F
KC
H
P
S
I
V
E
F
V
S
A
CLNP---DPSQ
R
A
T
A
Q
D
L
L
Q
M
S
LFSDS----THSDR
N
S
A
V
M
A
L
K
R
A
Q
L
L
H
V
L
------
N
K
F
V
AFQE
P
E
E
A
E
K
L
E
K
R
-
R
N
R
L
K
V
S
R
L
A
S
D
F
F
SSRSSSSDNASEP
M
S
T
---------
V
F
L-------NAAP
A
A
E
V
E
E
A
T
R
E
KRRPGA
A
V
T
T
A
AA
A
T
A
A
V
AAGNEDESDKDVTRRS
G
T
V
A
L
AAGGASESPDGARPAGASAGA
P
L
V
N
T
V
TSTDG
S
L
N
Q
A
A
S
T
F
T
R
Y
L
R
K
WDFSTSSSSSSSQLSANS
K
A
M
TAAGGEGAHRDPVTGVAGGNDE--AEPDARNPQTEGAYDLSPTPKKRSKTRSRPRATLTPPMRKPSHQRCCPDSTTTTTNSAEK
D
F
F
ATSSDNSSSGRALNEADARSEAPAHQGGT
A
R
L
T
G
T
ATTARNGPRPTGSEAVGYTPSFPGRRR
N
V
RLDEAGNIV
P
F
D
R
L
S
S
M
M
S
V
A
A
L
LNNKGEQHGDDASAEGSPGV
A
A
AAATEATAASRAPFPALGDANDHVLSPSSAAGLANASFTQPPGNY
S
F
F
G
FNR
N
I
S
F
MGT
N
M
D
E
V
L
N
S
A
A
N
D
F
L
S
N
L
A
ANWHTSN
A
A
C
V
E
T
A
SSAG
S
M
V
QLPS
R
T
F
L
R
AEGSGSGR
S
H
A
TLSSNREGECRT
D
R
V
VGVAS
P
L
A
VTGQSEDRGDVPKTPSRRRGGAISRSPSARSPLEARGPGEPASIEGGNSGVQHGGTTLPLPQLPPPKPLSTGAAPTAASRST
H
P
V
L
S
Q
LGSASYTSDDGTTSMTPRGDSV
P
L
V
GAAASS
H
R
Q
RRARPPITNQ
S
F
F
V
V
EDGSSAPLFSPHTGVTKSTGSMAGGPVSA
S
R
V
S
L
A
T
W
S
S
VASADGSVTGGVAGETS
S
S
T
L
L
Q
QNYA
N
V
A
V
V
APAPVFPTFST
S
S
A
R
A
V
W
Q
Q
R
R
R
HVAGGGRGGVGGGNM
S
N
I
H
L
TAPPSNE
G
S
V
Y
L
M
V
ADEQQGDG
Q
R
W
R
AAGASVSREGNDGDD
D
D
L
T
S
A
A
F
G
S
M
R
S
G
FSRRSSAQSTSNL
T
A
E
T
L
SATHEP
V
S
ERRPARSGDAAASASEGRRGAEVGDALP
F
S
N
L
A
S
E
A
D
S
M
V
F
T
Y
L
Q
R
I
D
A
S
L
Q
D
V
L
S
Q
L
Q
V
R
R
R
Q
C
RRKSGGSITGVQDGFDHAPSST
P
I
T
T
V
QATPPQ
S
A
T
Q
L
T
T
L
Q
S
S
L
S
S
ALPSPASANSTS
E
V
A
T
T
V
T
VSPQHHRSTGVSTSPAKLPR
P
L
S
SCTT
P
V
T
ISQSRQGKPNPLSMRASPPL
S
K
QCSNPRWPTEDEAEAEGDPVNHD
A
T
V
W
F
DTPLSPSSSGHRASSGCDDV
N
V
E
V
L
L
R
K
M
L
W
R
V
S
L
L
L
D
E
V
SSFSPRGPATASVARPP
32
HHSearch
66.85
31%
-59
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
-
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
--
G
S
Y
L
R
R
--
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
--------
T
-
G
P
---
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
--
T
D
N
G
-
H
V
----
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I-----
A
----
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
R
------
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
A
----
L
F
L
-
M
T
K
S
N
F
-
Q
P
P
K
L
----
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
---
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
----
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
66.80
31%
-32
- C1 -
-
3DAK
1
OXSR1_HUMAN
D:
[5-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
--
T
S
F
V
V
K
--
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GEHK
S
-
G
V
---
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
--
G
E
D
G
-
S
V
----
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
GDITRN------
F
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
--------
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
-
L
E
T
G
V
Q
D
K
----
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
---
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
66.30
35%
-0
- C1 -
-
2XIK
2
STK25_HUMAN
A:
[27-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
---------
P
-
G
P
---
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
Q
G
-
D
V
----
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
------
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---------
K
Q
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
-----
V
L
F
-
L
I
P
-
K
N
-
S
P
P
T
L
E
GQH
S
K
P
F
K
------
E
F
V
E
A
C
L
N
K
---
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
----
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.95
33%
2
- C1 -
-
4QMN
1
STK24_HUMAN
A:
[37-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
-
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
-
E
V
----
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
------
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---------
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
-----
V
L
F
-
L
I
P
-
K
N
-
N
P
P
T
L
----
E
G
N
Y
S
--
K
P
L
K
E
F
V
E
A
C
L
N
K
---
E
P
S
F
R
P
T
A
K
E
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
62.71
33%
3
- C1 -
-
4U8Z
1
STK24_HUMAN
A:
[22-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
-
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
-
E
V
----
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
------
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---------
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
-----
V
L
F
-
L
I
P
-
K
N
-
N
P
P
T
L
----
E
G
N
Y
S
--
K
P
L
K
E
F
V
E
A
C
L
N
K
---
E
P
S
F
R
P
T
A
K
E
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
62.70
24%
-50
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
---
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
A
------
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
--
G
--
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
--------
Q
-
G
C
---
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
--
S
S
D
G
S
H
A
----
A
L
C
D
F
G
H
A
V
C
L
Q
--------------
I
P
G
T
E
T
H
M
A
P
E
V
V
---------
L
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
F
F
R
G
P
L
C
L
K
I
A
S
E
-
P
P
P
-
V
R
-
E
I
P
P
---------
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
---
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
----
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
62.44
35%
-20
- C1 -
-
4NZW
1
STK25_HUMAN
B:
[28-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
---------
P
-
G
P
---
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
Q
G
-
D
V
----
K
L
A
A
F
G
V
A
G
--------------------
T
P
F
W
M
A
P
E
V
I
---------
K
Q
--
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
-----
V
L
F
-
L
I
P
-
K
N
-
S
P
P
T
L
EGQH
S
K
P
F
K
------
E
F
V
E
A
C
L
N
K
---
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
----
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.11
33%
1
- C1 -
-
3CKX
1
STK24_HUMAN
A:
[15-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
-
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
-
E
V
----
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
------
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---------
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
-----
V
L
F
-
L
I
P
-
K
N
-
N
P
P
T
L
----
E
G
N
Y
S
--
K
P
L
K
E
F
V
E
A
C
L
N
K
---
E
P
S
F
R
P
T
A
K
E
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
62.10
14%
20
- C1 -
-
4IM0
1
TBK1_HUMAN
A:
[5-663]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
-----
N
P
V
D
V
Q
M
R
E
F
E
V
L
K
K
L
N
H
K
N
I
V
K
L
F
--
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
--------
P
-
S
N
AYG
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
--
V
I
G
E
-
D
G
Q
S
V
Y
K
L
T
D
F
G
T
-----------------------
E
E
Y
L
H
P
D
M
Y
E
-------
R
V
L
R
K
D
H
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
-
I
I
T
-
G
K
-
P
S
G
A
I
----
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
CSL
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
EKCW
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
SLQQM
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
FPKTTEEN
P
I
F
V
V
S
R
E
P
L
N
T
I
G
L
I
Y
E
K
I
S
L
P
K
V
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
I
T
G
V
V
C
Y
A
C
R
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
I
R
W
L
I
E
L
I
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
E
K
T
V
K
V
M
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
S
L
Q
D
I
D
S
R
L
S
P
G
G
S
L
A
D
A
W
A
H
Q
E
G
T
H
P
K
DR
N
V
E
K
L
Q
V
L
L
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
T
H
F
T
D
E
C
V
K
K
Y
E
A
F
L
N
K
S
E
E
W
I
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
E
Y
T
N
E
L
Q
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
61.91
33%
2
- C1 -
-
3A7F
-
STK24_HUMAN
A:
[30-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
-
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
-
E
V
----
K
L
A
D
F
G
V
A
G
Q
L
------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---------
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
-----
V
L
F
-
L
I
P
-
K
N
-
N
P
P
T
L
----
E
G
N
Y
S
--
K
P
L
K
E
F
V
E
A
C
L
N
K
---
E
P
S
F
R
P
T
A
K
E
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
61.77
28%
-38
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[88-350]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
-
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
N
L
I
Q
L
Y
--
D
A
F
E
S
K
--
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
--------
E
S
Y
N
---
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
D
A
K
-
Q
I
----
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
------
E
K
L
K
-
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
---------
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
----
L
N
N
-
I
L
A
-
C
R
-
W
D
L
E
D
----
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
---
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.71
33%
3
- C1 -
-
4W8D
1
STK24_HUMAN
A:
[22-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
-
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
-
E
V
----
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
------
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---------
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
-----
V
L
F
-
L
I
P
-
K
N
-
N
P
P
T
L
----
E
G
N
Y
S
--
K
P
L
K
E
F
V
E
A
C
L
N
K
---
E
P
S
F
R
P
T
A
K
E
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
61.53
33%
4
- C1 -
-
3A7J
1
STK24_HUMAN
A:
[30-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
-
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
-
E
V
----
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
------
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---------
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
-----
V
L
F
-
L
I
P
-
K
N
-
N
P
P
T
L
----
E
G
N
Y
S
--
K
P
L
K
E
F
V
E
A
C
L
N
K
---
E
P
S
F
R
P
T
A
K
E
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
61.50
33%
2
- C1 -
-
4QML
2
STK24_HUMAN
A:
[37-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
-
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
-
E
V
----
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
------
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---------
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
-----
V
L
F
-
L
I
P
-
K
N
-
N
P
P
T
L
----
E
G
N
Y
S
--
K
P
L
K
E
F
V
E
A
C
L
N
K
---
E
P
S
F
R
P
T
A
K
E
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
61.49
33%
4
- C1 -
-
4W8E
1
STK24_HUMAN
A:
[22-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
-
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
-
E
V
----
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
------
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---------
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
-----
V
L
F
-
L
I
P
-
K
N
-
N
P
P
T
L
----
E
G
N
Y
S
--
K
P
L
K
E
F
V
E
A
C
L
N
K
---
E
P
S
F
R
P
T
A
K
E
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
61.45
24%
-61
- C1 -
-
2E9N
1
CHK1_HUMAN
A:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
--
G
H
R
R
E
G
--
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--------
D
-
I
G
---
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
--
D
E
R
D
-
N
L
----
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
---
R
L
L
N
-
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
--------
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
---
Y
S
D
-
W
K
E
-
K
---
K
T
Y
L
----
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
---
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
61.26
30%
-63
- C2 -
-
1RGS
2
?
?:
[22-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
V
I
P
K
D
Y
K
T
M
A
A
L
A
K
A
I
E
K
N
V
L
F
S
H
L
D
D
N
E
R
S
D
I
F
D
A
M
F
P
V
S
F
I
A
G
E
T
V
I
Q
Q
G
D
-
E
G
D
N
F
Y
V
I
D
Q
G
E
M
D
V
Y
V
N
N
E
W
A
T
S
V
G
E
G
G
S
F
G
E
L
A
L
I
Y
G
T
P
R
-
A
A
T
V
K
A
K
T
N
V
K
L
W
G
I
D
R
D
S
Y
R
R
I
L
M
G
S
T
L
R
K
R
K
M
Y
E
E
F
L
S
K
V
S
I
L
E
S
L
D
K
W
E
R
L
T
V
A
D
A
L
E
P
V
Q
F
E
D
G
Q
K
I
V
V
Q
G
E
P
G
D
E
F
F
I
I
L
E
G
S
A
A
V
L
Q
R
R
S
E
N
E
E
F
V
E
V
G
R
L
G
P
S
D
Y
F
G
E
I
A
L
L
M
N
R
P
R
A
A
T
V
V
A
R
G
-
P
L
K
C
V
K
L
D
R
P
R
F
E
R
V
L
G
P
C
S
D
I
L
K
R
N
I
Q
Q
Y
N
S
F
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
60.79
33%
2
- C1 -
-
4QMQ
3
STK24_HUMAN
A:
[37-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
-
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
-
E
V
----
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
------
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---------
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
-----
V
L
F
-
L
I
P
-
K
N
-
N
P
P
T
L
----
E
G
N
Y
S
--
K
P
L
K
E
F
V
E
A
C
L
N
K
---
E
P
S
F
R
P
T
A
K
E
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
60.69
33%
5
- C1 -
-
4QMO
3
STK24_HUMAN
A:
[37-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
-
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
-
E
V
----
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
------
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---------
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
-----
V
L
F
-
L
I
P
-
K
N
-
N
P
P
T
L
----
E
G
N
Y
S
--
K
P
L
K
E
F
V
E
A
C
L
N
K
---
E
P
S
F
R
P
T
A
K
E
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
60.59
33%
1
- C1 -
-
4QMP
2
STK24_HUMAN
A:
[37-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
----
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
-
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
-
E
V
----
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
------
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---------
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
-----
V
L
F
-
L
I
P
-
K
N
-
N
P
P
T
L
----
E
G
N
Y
S
--
K
P
L
K
E
F
V
E
A
C
L
N
K
---
E
P
S
F
R
P
T
A
K
E
L
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------