@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_15_1630: (2018-03-08 )
MPTKMAAADFEFGPPLGTGAFSKVVVGLYKPTNVRYAVKFISKRSILDAPTDEERTRMAEVARRETRMLLMCEHPNIVKFHASMQTTEDLLYVTELCEGGELLKHIERWGHIPLEAARHAIAELFSAVFYLHHGEKKSNSGPSGPAMKPLTVIHRDIKPENIMLSADKHLRLIDFGTAVVCQSADDKATGEETGSGRAQTFCGTTYYMSPELLESSYTCCASDYWGCGCVLYLMLVGQRPFDASTQYLLIKTILEKEPEFPEDMDPDAKDLIRKLLVKDPKARIGMKEIKRHPFLASVNLSTVANQDVADFWLRETPWVDEASISACMACQRPFGILRSKQFCHNCGRITCNSCIRDLRIIPESRWKAPQRVCTACAGTLNGVSTL
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70.........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.....-.------.------290.......300.......310.......320.......330.......340.......350.......360.......370.......380....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPTKMAAADFEFGPPLG
T
G
A
F
S
K
V
V
V
GLYKPT
N
V
R
Y
A
V
K
F
I
S
KRSILDAPT
D
E
E
R
T
R
M
A
E
V
A
R
RE
T
R
M
L
L
-
M
CEHP
N
I
V
K
F
HASMQ
T
T
E
D
L
L
Y
V
T
E
LCE
G
G
E
L
L
K
H
I
E
R
WGHI
P
L
E
A
A
R
H
A
I
A
E
L
F
S
A
V
F
Y
L
HHGEKKSNSGPSGPAMK
P
L
T
V
I
HRDIKPE
N
I
M
LSADK
H
L
R
L
I
DFG
T
A
V
V
CQSADDKATGEETGSGR
A
Q
T
F
CGTTYYM
S
P
E
L
L
E
SSYTCCASDYW
G
C
G
C
V
L
Y
L
M
L
VGQRPFDASTQ
Y
L
L
I
K
T
I
L
EKEPEFPEDMDP
D
A
K
D
L
I
R
K
L
L
VKDPKARI
G
M
K
-
E
------
I
------
K
RHP
F
L
A
SVN
L
S
TVAN
Q
D
V
A
D
F
W
LRETPWV
D
E
A
S
I
S
A
C
M
A
C
QR
P
F
G
I
L
R
S
K
Q
F
C
H
NCGRI
T
C
N
S
C
I
R
D
L
R
IIPESRWK
A
P
Q
R
V
C
T
A
C
A
GTLNGVSTL
40
HHSearch
84.25
39%
-130
* C1 *
-
5LVO
4
PDPK1_HUMAN
A:
[29-305]
----
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-------
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
G
----------------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
K
Q
--------
A
R
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
------
M
EG
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
25
HHSearch
81.31
40%
-121
- C1 -
-
1UVR
8
PDPK1_HUMAN
A:
[6-284]
---
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-------
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
G
----------------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
------------
A
R
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
------
M
EG
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
T
-------------------------------------------------------------------------------
5
PsiBlast_PDB
79.26
36%
-115
- C1 -
-
1H1W
9
PDPK1_HUMAN
A:
[4-283]
-
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
P
----
A
R
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEG
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
10
PsiBlast_PDB
78.07
36%
-120
- C1 -
-
3NUY
5
PDPK1_HUMAN
A:
[2-281]
-
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
---------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
ME
G
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
13
PsiBlast_PDB
77.89
36%
-135
- C1 -
-
3ION
1
PDPK1_HUMAN
A:
[34-306]
--------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
-------
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
-----------
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEGY
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
4
PsiBlast_PDB
76.90
36%
-121
- C1 -
-
2PE2
9
PDPK1_HUMAN
A:
[1-280]
-
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEG
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
9
PsiBlast_PDB
76.62
36%
-120
- C1 -
-
3NUU
5
PDPK1_HUMAN
A:
[2-281]
-
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
---------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEG
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
8
PsiBlast_PDB
76.53
36%
-117
- C1 -
-
3NUS
5
PDPK1_HUMAN
A:
[2-281]
-
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
---------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEG
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
7
PsiBlast_PDB
76.51
36%
-118
- C1 -
-
1UU9
8
PDPK1_HUMAN
A:
[3-282]
-
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
---------
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEG
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
6
PsiBlast_PDB
76.47
36%
-110
- C1 -
-
1UVR
8
PDPK1_HUMAN
A:
[4-283]
-
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
P
----
A
R
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEG
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
14
PsiBlast_PDB
76.42
36%
-118
- C1 -
-
2BIY
8
PDPK1_HUMAN
A:
[31-303]
--------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
P
E
S
K
Q
A
R
A
N
A
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEGY
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
18
PsiBlast_PDB
76.40
36%
-119
- C1 -
-
1UU7
4
PDPK1_HUMAN
A:
[31-303]
--------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
P
-----
R
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEG
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
12
PsiBlast_PDB
76.15
36%
-133
- C1 -
-
2R7B
2
PDPK1_HUMAN
A:
[34-306]
--------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
-------
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
-----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEGY
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
20
PsiBlast_PDB
75.62
36%
-120
- C1 -
-
1OKY
4
PDPK1_HUMAN
A:
[31-303]
--------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
P
------
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEG
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
1
PsiBlast_PDB
75.58
36%
-118
- C1 -
-
1Z5M
4
PDPK1_HUMAN
A:
[1-280]
-
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEG
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
2
PsiBlast_PDB
75.26
36%
-119
- C1 -
-
2PE0
4
PDPK1_HUMAN
A:
[1-280]
-
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEG
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
3
PsiBlast_PDB
75.17
36%
-119
- C1 -
-
2PE1
5
PDPK1_HUMAN
A:
[1-280]
-
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEG
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
15
PsiBlast_PDB
74.88
36%
-124
- C1 -
-
3NAY
1
PDPK1_HUMAN
A:
[30-302]
--------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
--------
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
ME
G
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
17
PsiBlast_PDB
74.74
36%
-129
- C1 -
-
1UU3
9
PDPK1_HUMAN
A:
[31-303]
--------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
ME
G
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
19
PsiBlast_PDB
74.07
36%
-124
- C1 -
-
1UU8
7
PDPK1_HUMAN
A:
[31-303]
--------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
--------
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
MEG
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
16
PsiBlast_PDB
73.28
36%
-126
- C1 -
-
3RWP
5
PDPK1_HUMAN
A:
[33-305]
--------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--------
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
------
G
K
G
----------
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
--------
K
V
L
S
---------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
ME
G
Y
G
P
L
------
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------------
27
HHSearch
66.78
33%
-78
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[3-274]
-----
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-------
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
----------------
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
----------
A
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
G
D
------
I
------
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
------------------------------------------------------------------------------