@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_16_0870: (2018-03-09 )
MSSSAGDYGESYQRSDERNELASSGEKSENAAYGWPSEMLNACTDFSAPQSSYQLNAQTPPPFAPFAPSPLSRPASQSAPTQQRSEGTPLQAETARKHGSSLRAHTSTFQSTLSSAAPSLGSGELSSSPFPHRHSDTYERPLPPEALGARQLVDYIFTPHSPGRPHSSLSPPSVVPRPSPREIGWPMPLLAEPVNPSSGRRLVFFGKGQQPQFVLGEKKNRFIAVTFKPILSVAAAAVVSAAPELGDTSTTTGYASYGTVLGYSDDNTKIVWHDRSERFASYVSLSSIQSIHRASAMQCRHCGFVLLKQELREHMNTHKKGSGVEYGVFTDDESLGMLCGDSGLMQNLASPRRLGEGAQGVVDLMEVVQPTMEEVAQAGPSSAAYRFVSEHLSHESRLQKVVLKSMHFSSEAKALDEYQKSVRFMTVMQHPHLVEYLAVQLKPDRRTVCICMPYYQEGDVGAMIRSFRGDHFDESFVCSVALQLSLALAFLHERNPPIVHGDLKVENAMFYNNKQQIVLTDLDASREVLGGYQEAVQSSLGTTAYMAPETLKVERLMPSSDMWSLGVFLYVLTVLPDFPMILNPNTQNLDLLNADCWATEEDLRAMESYSSALNDGHSNAPSVNAGSGNCGITLGECVRANITRKGYSRDLAQLVVDLLSYNPLKRPTAEVVGCRLTEIMTDYLLEF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420...-...-.430.......440.......450.......460......--------------.470........480.......490.......500.......510--.-.-.---.....520.......530-.---.----.....540.......550.------......560.......570.......580.......590.......600.......610.......620.......630.......640.-......650.......660.......670.......680.....------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSSSAGDY
G
E
S
YQRS
D
E
R
N
E
L
ASSGEKSENAAYG
W
P
S
E
M
L
N
A
CTDFSAPQS
S
Y
Q
LNAQTPPPFAPFAPSPLSRPASQSAPTQQRSEGTPL
Q
A
E
T
A
R
KHGSS
L
R
A
H
T
S
T
F
Q
S
T
L
S
S
AAPSLGSGELSSSPFPHRHSDTYERPL
P
P
E
A
L
G
A
R
Q
L
V
D
Y
I
FTPHSPGRPHSSLSPPSVVPRPSPREIGWPMPLLAEPVNPSSG
R
R
L
V
F
F
GKGQQP
Q
F
V
LGEKKN
R
F
I
A
V
T
F
K
P
I
L
S
V
A
A
A
A
V
V
SAAPELGDTSTTTGYAS
Y
G
T
V
L
GYSDDN
T
K
I
V
W
HD
R
S
E
R
F
A
S
Y
V
S
L
S
S
I
Q
S
I
H
R
A
S
A
M
Q
C
R
H
C
G
F
V
L
L
K
Q
E
L
R
E
H
M
N
THKKGSG
V
E
Y
G
V
FTDDE
S
L
G
M
LCG
D
S
G
L
M
Q
N
LA
S
P
R
RLGE
G
A
Q
G
V
V
D
L
M
E
V
V
Q
P
T
M
E
E
V
A
QAGP
S
S
A
A
Y
R
F
V
S
E
HL
S
H
E
S
R
L
Q
K
V
V
L
K
S
MHF
S
S
E
A
K
A
L
D
E
Y
Q
K
S
V
R
F
M
-
T
V
M-QHP
H
L
V
E
Y
L
A
V
QLKPDR
R
T
V
C
I
CMPYYQEG
D
V
G
A
M
I
R
S
F
R--------------GDH-F
D
E
S
F
V
C
S
V
A
L
Q
L
S
L
A
L
A
F
L
HERNP
P
I
V
HGD
L
K
V
E
N
A
M
F
Y---N-N-K---
Q
Q
I
V
L
TDLDA
S
R
E
V
L
G
G
Y
-
Q
---
E
----
A
V
Q
S
SLGTTAYMAPE
T
L
K
V
------
E
RLMPSS
D
M
W
S
L
G
V
F
L
Y
V
L
T
VLPDF
P
M
I
LNPNTQNLDLLNADCWA
T
E
E
D
L
R
A
M
E
S
Y
S
S
A
LNDGHSNAPSVNAGSGNCGI
T
L
G
E
C
V
R
A
NIT-RKG
Y
S
R
D
L
A
Q
L
V
V
D
L
LSYNPLKR
P
T
A
E
V
V
G
C
R
L
T
E
I
M
T
D
Y
L
LEF------------------------------------------------------------------------
41
HHSearch
83.50
21%
-132
- C1 -
-
5U9D
6
A:
[12-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
----------------------------
Y
D
V
A
I
K
M
I
K
E
G
S
M
--
S
E
D
E
F
I
E
E
A
K
V
M
-
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
--
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
---------------
H
R
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
--
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
-
Q
-----
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
-
Y
---
T
----
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
------
S
K
F
S
S
K
S
D
I
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A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
--------
H
-------------
I
A
Q
G
-----------------
L
R
-----
L
Y
R
-
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
------------------------------------------------------------------------------
29
HHSearch
81.30
21%
-134
- C1 -
-
4Y95
4
?
A:
[7-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
----------------------------
Y
D
V
A
I
K
M
I
K
E
G
S
M
--
S
E
D
E
F
I
E
E
A
K
V
M
-
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
--
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
---------------
H
R
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
--
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
-
Q
-----
G
V
V
K
V
S
D
F
G
M
T
R
F
V
L
D
D
E
-
Y
---
T
----
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
L
M
Y
------
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
--------
H
-------------
I
A
Q
G
---------------------
L
R
L
-
P
R
-
P
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
-----------------------------------------------------------------------------
36
HHSearch
80.95
21%
-131
- C1 -
-
5P9J
1
A:
[20-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
----------------------------
Y
D
V
A
I
K
M
I
K
E
G
S
M
--
S
E
D
E
F
I
E
E
A
K
V
M
-
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
--
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
---------------
H
R
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
--
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
-
Q
-----
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
-
Y
---
T
-------
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
------
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
--------
A
E
H
------
I
-------
A
Q
G
---------------------
L
R
-
L
Y
R
-
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
-----------------------------------------------------------------------------
24
HHSearch
78.73
21%
-127
- C1 -
-
5T18
1
A:
[8-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
----------------------------
Y
D
V
A
I
K
M
I
K
E
G
S
M
--
S
E
D
E
F
I
E
E
A
K
V
M
-
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
--
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
--------------------
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
--
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
-
Q
-----
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
-
Y
---
T
----
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
------
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
--------
H
-------------
I
A
Q
G
---------------------
L
R
-
L
Y
R
-
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
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T
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K
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S
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I
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M
D
E
-----------------------------------------------------------------------------
22
HHSearch
78.19
20%
-87
- C1 -
-
3BKB
7
A:
[114-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
---------------------------
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
-
K
Q
Y
-
S
H
P
N
I
V
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L
I
G
V
C
T
Q
--
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
---------------
A
R
-
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
-
K
-----
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
-
Y
A
--
A
----
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
------
G
R
Y
S
S
E
S
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V
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S
F
G
I
L
L
W
E
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F
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L
G
A
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P
Y
P
N
L
S
N
Q
Q
T
R
E
---------------------
F
V
E
K
G
-------------
G
R
L
P
---------
C
-
P
E
L
C
P
D
A
V
F
R
L
M
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Q
C
W
A
Y
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P
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L
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S
I
R
K
R
-----------------------------------------------------------------------------
27
HHSearch
77.97
20%
-139
- C1 -
-
4TWP
1
ABL1_HUMAN
B:
[8-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
I
T
M
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H
K
L
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G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
---------------------------
L
T
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
E
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A
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-
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L
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C
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R
--
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I
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F
M
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L
R
E
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N
--------------
R
Q
E
-
V
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V
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L
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E
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--
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A
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N
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---
E
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N
-----
H
L
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K
V
A
D
F
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R
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G
D
T
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Y
---
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----
A
H
A
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T
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P
E
S
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A
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------
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Q
V
-------
Y
E
L
-------------
L
E
K
D
---------------
Y
R
M
-------
E
R
-
P
E
G
C
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I
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Q
A
F
E
T
M
F
Q
E
-----------------------------------------------------------------------------
23
HHSearch
76.87
20%
-90
- C1 -
-
3CBL
3
A:
[114-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
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N
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F
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G
R
L
R
A
D
N
---------------------------
T
L
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A
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Y
-
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C
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--
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T
F
L
R
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G
---------------
A
R
-
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
-
K
-----
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
-
Y
A--
A
----
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
------
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
-
Q
T
R
--------
E
------------
F
V
E
K
G
-------------
G
R
L
P
---------
C
-
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
-----------------------------------------------------------------------------
31
HHSearch
76.83
19%
-128
- C1 -
-
5DA3
3
PTK6_HUMAN
A:
[6-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
K
D
R
----------------------------
V
Q
V
A
I
K
V
I
S
R
D
N
-
L
L
H
-
Q
M
L
Q
S
E
I
Q
A
M
-
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
--
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
--------------
E
K
V
-
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
--
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
-
N
-----
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
--
V
---
Y
----
L
S
H
D
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
------
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
-
E
--
A
F
L
-----
R
-------------
V
D
A
G
-------------
Y
--
R
M
-
P
------
C
-
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
T
S
H
-----------------------------------------------------------------------------
33
HHSearch
75.52
22%
-133
- C1 -
-
4HCU
1
A:
[10-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
----------------------------
D
K
V
A
I
K
T
I
R
E
G
A
M
--
S
E
E
D
F
I
E
E
A
E
V
M
-
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
--
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
---------------
G
L
-
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
-
N
-----
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
---
T
----
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
-
E
--
V
V
E
-----
D
-------------
I
S
T
G
-----------------
F
R
-----
L
Y
K
-
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
-----------------------------------------------------------------------------
39
HHSearch
72.38
22%
-130
- C1 -
-
3T9T
3
A:
[8-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
----------------------------
D
K
V
A
I
K
T
I
R
E
G
A
M
--
S
E
E
D
F
I
E
E
A
E
V
M
-
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
--
Q
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
---------------
G
L
-
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
-
N
-----
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
---
T
----
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
--------
D
-------------
I
S
T
G
-----------------
F
R
-----
L
Y
K
-
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
-----------------------------------------------------------------------------
42
HHSearch
69.97
22%
-16
- C1 -
-
3TT0
1
FGFR1_HUMAN
A:
[69-353]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
--------------------
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
-
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
--
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PPGLEYSYNPSHNP
E
E
Q
-
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
-
D
-----
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
---
K
----
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
------
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
-
E
--
L
F
-----
K
L
-------------
L
K
E
G
-------------
H
--
R
M
-------
D
K
-
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
-----------------------------------------------------------------------------
21
HHSearch
68.04
21%
-43
* C1 *
-
2PSQ
-
B:
[80-366]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
-----------------------
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
-
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
--
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
PPG-----------
E
E
Q
-
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
-
N
-----
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
-
Y
Y--
K
----
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
------
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
--
L
F
------------------
K
L
L
K
E
G
-------------
H
R
M
D
---------
K
-
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
----------------------------------------------------------------------------
46
Fugue
67.60
17%
-28
- C1 -
-
4EUT
1
TBK1_HUMAN
A:
[2-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
---
D
L
F
A
I
K
V
F
N
N
I
S
F
L
R
P
V
D
V
Q
M
R
E
F
E
V
L
-
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
--------------
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
--
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
-
G
-
Q
---
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
--
E
D
-
D
---
E
----
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
VLD
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
-
G
S
L
P
F
R
P
F
E
G
P
R
R
----------
N
K
E
V
M
Y
K
I
I
T
G
K
P
------
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
LQQM
T
A
H
K
I
Y
I
H
SYNT
A
T
I
F
H
E
L
V
Y
K
Q
T
KIISSN
Q
E
L
I
Y
EG
R
R
L
V
L
E
PGRLAQHFPKTTEE
N
P
I
F
V
V
S
RE
32
HHSearch
66.55
22%
-90
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[90-343]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
---------------------------
L
K
L
A
A
K
I
I
K
T
R
G
M
-
K
D
K
E
E
V
K
N
E
I
S
V
M
-
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
--
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
---------------
Y
N
-
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
--
I
L
H
L
D
L
K
P
E
N
I
L
C
V
---
N
R
D
-
A
---
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
------
E
----
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
------
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
-
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
R
---------------------------------
W
--
D
L
E
-----
D
E
E
-
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
------------------------------------------------------------------------------------
37
HHSearch
65.91
21%
-90
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[21-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
---------------------------
K
T
Y
M
A
K
F
V
K
V
K
G
T
--
D
Q
V
L
V
K
K
E
I
S
I
L
-
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
--
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
---------------
F
E
-
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
---
T
-
R
R
S
---
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
------
D
----
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
------
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
-
N
P
F
L
A
E
T
N
Q
Q
I
I
--------
E
N
-------------
I
M
N
A
--------------
E
Y
T
F
D
E
-----
E
A
-
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
------------------------------------------------------------------------------------
35
HHSearch
65.78
19%
-99
- C1 -
-
4IDV
1
M3K14_HUMAN
A:
[75-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
---------------------------
F
Q
C
A
V
K
K
V
R
L
E
V
------
F
R
A
E
E
L
M
A
C
-
A
G
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
--
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
----------------
C
-
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
---
S
-
D
-
G
---
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
P
D
G
-
L
---
G
KSLL
T
G
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
------
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
-
H
P
W
T
Q
F
F
R
G
-
P
L
C
------
L
K
I
--------------
A
S
E
--------------
P
P
P
V
R
------
E
I
-
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
----------------------------------------------------------------------------
38
HHSearch
63.89
20%
-41
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[7-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
G
Y
V
V
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
---------------------------
M
E
Y
A
V
K
V
I
D
K
S
K
R
-----
D
P
S
E
E
I
E
I
L
L
R
Y
G
-
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
--
G
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
Q
K
----------------
F
-
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
--
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
---
D
-
E
-
S
GNP
E
C
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
--
N
---
G
----
L
L
M
T
P
C
Y
---
F
V
A
P
E
V
L
K
R
------
Q
G
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
-
T
P
F
A
N
G
P
S
D
T
P
E
E
I
L
T
------------------
R
I
G
--------------
S
G
K
F
T
L
S
G
G
-----
N
-
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
K
Q
V
L
Q
H
P
-----------------------------------------------------------------------------------
40
HHSearch
63.53
18%
-99
- C1 -
-
4KNB
2
MET_HUMAN
C:
[18-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-------------------------------
I
H
C
A
V
K
S
L
N
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
-
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--------------
H
-
N
-
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
--
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
-
K
-----
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
-
Y
YSV
H
------
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
------
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
----
V
Y
L
---------------
L
Q
-
G
-------------
R
R
L
---------
L
Q
-
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
---------------------------------------------------------------------------
34
HHSearch
63.12
18%
-105
- C1 -
-
4KNB
3
MET_HUMAN
A:
[18-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-----------------------------
K
I
H
C
A
V
K
S
L
---
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
-
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
-
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
---------------
H
N
-
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
--
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
-
K
-----
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
-
Y
YSV
H
----
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
------
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
-
V
N
T
F
D
I
T
----
V
Y
L
----------------
L
Q
G
-------------
R
R
L
---------
L
Q
-
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------------------------------------
28
HHSearch
59.93
18%
-114
- C1 -
-
4G3F
1
A:
[58-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
---------------------------
F
Q
C
A
V
K
K
V
R
L
E
V
------
F
R
V
E
E
L
V
A
C
-
A
G
L
-
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
--
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
G
----------------
C
-
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
---
S
-
D
-
G
---
S
R
A
A
L
C
D
F
G
H
A
L
C
L
----------------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
------
K
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
-
H
P
W
T
Q
Y
F
R
G
-
P
--
L
C
----
L
K
I
--------------
A
S
E
--------------
P
P
P
I
R
------
E
I
-
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
-----------------------------------------------------------------------------