@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_16_1000: (2018-03-09 )
MSTAGRYKHVVKLGEGTYGSVYKGTEIQTGKVVAFKRMVVTSDDEGVPGAAIREICLLKELRHDNVVDLFEVLFEPPKITMIFELCDCDLKRFMESRPKRLLDAEAEMRPILKQIFIGLEYLHSRSVVHRDMKPQNIFVNVRAPDFAALTASPSSRQDHLQPPPFSGVPTAVGGDVQSAAGSDGRPNPFAGADSVPPWEAAAAAPSNTPNQLIVKIGDFGLARVEEIPVKKYSHEVVTLWYRSPDVLMGSALYSYPVDIWSMGAIFFEMATSKVLFSGRHEDEQLLRMFWLLGSPTRETWPSMLSYPGAMERLERASRAAAERPDLRFGSEVYVQQQQQPPSSQSHSGGRAPDLLTQIAHKRFYHSLKAIQQREESARSSSNTYQLPVELWFDRPLFGEYMSATGFDSCVTAEGVNLLRQCLLYEPNHRITAAAAVRHAYLHAVSVPTAGALDVLMTSLLQTMEACHLL
Atome Classification :
(25 SA)
--------------------------------------------------------------.........10........-20........30........40........50........60-........70....-....80......-..90......-.-.100.......110--..-......120.......130.......140--.........150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270........280.......290.......300.......310.......320.......330......-.340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......-----------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------------------------------MSTAG
R
Y
K
H
V
V
KLGEGTYG-SVYKGTEIQTG
K
V
V
A
F
K
R
M
V
V
TSDDEGV
P
G
A
A
I
R
E
I
C
L
L
K
E
L-RHD
N
V
V
D
L
F
E
V
LFE-PP
K
I
T
M
I
F
E
L
C
D
-
C
D
L
K
R
F
M
E
SR-
P
-
K
R
L
L
D
A
E
A
E
M
R
P
I
---
L
K
-
Q
I
F
I
G
L
E
Y
L
H
S
R
S
V
V
HRDMKPQ
N
I
F
V
N
----VRAP
D
F
A
A
LTASPSSRQDHLQPPPFSGVPTAVGGD
V
Q
SAAGSDGRPNPFAGADSVPP
W
E
AAAAAPSNTP
N
Q
L
I
V
K
IGDFG
L
A
R
V
E
EI
P
V
K
KYSH
E
V
V
T
L
W
YRSP
D
V
L
M
G
S
A
L
YSY
P
V
D
I
W
S
M
G
A
I
F
F
E
MAT-
S
K
V
L
FSGRH
E
D
E
Q
L
L
R
M
F
W
L
LGS
P
T
R
E
T
W
P
S
M
LSYP
G
A
M
E
R
L
E
R
A
S
R
AAAERPDLRFG
S
E
V
Y
V
Q
QQQ-QPPSSQSHSGGR
A
P
D
L
L
T
Q
I
A
H
K
R
F
Y
H
S
L
K
A
I
Q
Q
R
E
E
SARSSSN
T
Y
Q
L
P
V
E
L
WFDR
P
L
F
G
E
Y
M
S
ATGFDSCV
T
A
E
G
V
N
L
L
R
Q
C
LLYEPNHR
I
T
A
A
A
A
V
R
H
A
Y
L
H
A
VSVPTA
G
A
L
D
V
L
M
T
S
L
L
Q
T
M
E
A
CHLL-----------------
25
HHSearch
83.69
51%
-118
* C1 *
-
5LQF
1
CDK1_HUMAN
D:
[5-221]
----------------------------------------------------------------
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
-
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
-
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
-
D
S
R
L
Y
L
I
F
E
F
L
S
-
M
D
L
K
K
Y
L
D
S
I
-
P
-
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
---
L
Y
-
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
----
D
---------------------------------------------------------------------
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
-------
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
83.63
51%
-117
- C1 -
-
4YC3
1
CDK1_HUMAN
A:
[5-221]
----------------------------------------------------------------
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
-
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
-
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
-
D
S
R
L
Y
L
I
F
E
F
L
S
-
M
D
L
K
K
Y
L
D
S
I
-
P
-
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
---
L
Y
-
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
----
D
---------------------------------------------------------------------
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
V
Y
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
78.21
47%
-120
- C1 -
-
3QHW
2
CDK2_HUMAN
A:
[3-210]
-----------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
-
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
-
N
H
P
N
I
V
K
L
L
D
V
I
H
T
-
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
-
A
-
L
-
T
G
I
P
L
P
L
I
K
S
Y
---
L
F
-
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
----
T
---------------------------------------------------------------------
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
76.95
45%
-139
- C- -
-
3GBZ
-
?
A:
[12-222]
-----------------------------------------------------------------
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
-
E
V
Y
K
A
I
D
T
V
T
N
E
T
V
A
I
K
R
I
R
L
E
H
--------
A
I
R
E
V
S
L
L
K
E
L
-
Q
H
R
N
I
I
E
L
K
S
V
I
H
H
-
N
H
R
L
H
L
I
F
E
Y
A
E
-
N
D
L
K
K
Y
M
D
K
N
-
P
----
D
V
S
M
R
V
I
K
S
F
---
L
Y
-
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
----
V
---------------------------------------------------------------------
T
P
V
L
K
I
G
D
F
G
L
A
R
A
F
G
-----------
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
-
K
T
P
L
F
P
G
D
S
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
76.62
45%
-135
- C1 -
-
3GC0
1
?
A:
[33-243]
-----------------------------------------------------------------
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
-
E
V
Y
K
A
I
D
T
V
T
N
E
T
V
A
I
K
R
I
R
L
E
H
-------
T
A
I
R
E
V
S
L
L
K
E
L
-
Q
H
R
N
I
I
E
L
K
S
V
I
H
H
-
N
H
R
L
H
L
I
F
E
Y
A
E
-
N
D
L
K
K
Y
M
D
K
N
-
P
----
D
V
S
M
R
V
I
K
S
F
---
L
Y
-
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
----
V
--------------------------------------------------------------------
E
T
P
V
L
K
I
G
D
F
G
L
A
R
A
F
---------
E
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
-
K
T
P
L
F
P
G
D
S
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
76.02
45%
-122
- C1 -
-
5G6V
1
CDK16_HUMAN
B:
[2-214]
------------------------------------------------------------------
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
-
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
H
E
-
E
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
-
K
H
A
N
I
V
T
L
H
D
I
I
H
T
-
E
K
S
L
T
L
V
F
E
Y
L
D
-
K
D
L
K
Q
Y
L
D
D
C
-
G
-
N
--
I
I
N
M
H
N
V
K
L
F
---
L
F
-
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
----
E
---------------------------------------------------------------------
R
G
E
L
K
L
A
D
F
G
L
A
R
A
------------
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
75.25
45%
-100
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[2-214]
------------------------------------------------------------------
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
-
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
H
E
-
E
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
-
K
H
A
N
I
V
T
L
H
D
I
I
H
T
-
E
K
S
L
T
L
V
F
E
Y
L
D
-
K
D
L
K
Q
Y
L
D
D
C
-
G
-
N
--
I
I
N
M
H
N
V
K
L
F
---
L
F
-
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
----
E
---------------------------------------------------------------------
R
G
E
L
K
L
A
D
F
G
L
A
R
A
K
-----
T
Y
D
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
75.22
47%
-137
- C1 -
-
4EK4
1
CDK2_HUMAN
A:
[2-209]
-----------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
-
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
-
N
H
P
N
I
V
K
L
L
D
V
I
H
T
-
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
-
A
-
L
-
T
G
I
P
L
P
L
I
K
S
Y
---
L
F
-
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
----
T
---------------------------------------------------------------------
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
75.19
48%
-105
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[2-205]
------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
-
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
-
K
H
K
N
I
V
R
L
H
D
V
L
H
S
-
D
K
K
L
T
L
V
F
E
F
C
D
-
Q
D
L
K
K
Y
F
D
S
C
-
N
-
G
--
D
L
D
P
E
I
V
K
S
F
---
L
F
-
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
----
R
---------------------------------------------------------------------
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
-
A
G
R
P
L
F
P
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
71.51
48%
-98
- C1 -
-
4AU8
2
CDK5_HUMAN
A:
[4-208]
----------------------------------------------------------------
G
S
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
-
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
-
K
H
K
N
I
V
R
L
H
D
V
L
H
----
K
L
T
L
V
F
E
F
C
D
-
Q
D
L
K
K
Y
F
D
S
C
-
N
-
G
--
D
L
D
P
E
I
V
K
S
F
---
L
F
-
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
----
R
---------------------------------------------------------------------
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
-
A
G
R
P
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
66.24
34%
-102
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-237]
---------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
-
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
I
---------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
-
S
H
P
N
I
I
G
L
L
D
A
F
G
H
-
K
S
N
I
S
L
V
F
D
F
M
E
-
T
D
L
E
V
I
I
K
D
N
-
S
-
L
--
V
L
T
P
S
H
I
K
A
Y
---
M
L
-
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
----
E
---------------------------------------------------------------------
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
62.17
23%
-5
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
S
V
E
E
Y
L
V
H
A
L
QG
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
RSREPSPKTE
D
N
E
G
V
L
LTEK
L
K
P
V
DY
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
-
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
A
-------
E
E
L
M
A
C
A
G
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
-
G
P
W
V
N
I
F
M
E
L
L
E
-
G
G
S
L
G
Q
L
V
K
E
-
Q
-
G
C
L
--
P
E
D
R
A
L
Y
Y
---
L
G
-
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
---------------------------------------------
S
D
G
S
H
---------------------------
A
A
L
C
D
F
G
H
A
V
C
L
Q
I
P
G
--------
T
E
T
H
M
A
P
E
V
V
L
G
R
S
-
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
F
F
R
G
P
-------------------------
L
C
L
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
------------------------------------------------------------------------------------
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
--
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
---------------------
32
HHSearch
61.98
28%
-54
- C1 -
-
3EB0
2
?
A:
[6-279]
-----------------------------------------------------------------
S
K
K
Y
S
L
G
K
T
L
G
T
G
-
F
G
-
I
V
C
E
V
F
D
I
E
S
G
K
R
F
A
L
K
K
V
L
Q
D
P
------
R
Y
K
N
R
E
L
D
I
M
K
V
L
-
D
H
V
N
I
I
K
L
V
D
Y
F
Y
T
T
N
K
Y
L
N
V
I
M
E
Y
V
P
-
D
T
L
H
K
V
L
K
S
F
-
I
R
S
G
R
S
I
P
M
N
L
I
S
I
Y
---
I
Y
-
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
----
S
K
--------------------------------------------------------------------
D
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
P
S
-
E
P
S
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
-
G
K
P
L
F
S
G
E
T
S
I
D
Q
L
V
R
I
I
Q
I
M
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
61.88
20%
-47
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
--------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
-
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
D
Q
V
---
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
-
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
-
A
-
F
E
L
--
N
E
R
E
I
V
S
Y
---
V
H
-
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
-----------------------------------------------------------------------
T
R
R
S
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
-
P
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
-
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
E
A
F
K
E
----------
I
S
I
E
A
M
D
F
V
D
R
-------------------------------
L
L
V
K
E
R
K
S
R
-----------------------
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
-----------------------------
46
Fugue
61.43
21%
-14
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
-----------------------------------------------------------NFE
Q
S
L
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
T
V
V
F
Q
G
S
--
F
Q
G
R
P
V
A
V
K
R
M
L
-----
I
D
F
C
D
I
A
L
M
E
I
K
L
L
T
E
S
D
D
H
P
N
V
I
R
Y
Y
C
S
E
T
T
-
D
R
F
L
Y
I
A
L
E
L
C
N
-
L
N
L
Q
D
L
V
E
S
K
-
Y
---------
N
P
I
S
L
---
L
R
-
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
S
----
T
S
--------------------------------------------------------
S
R
F
T
A
D
Q
Q
T
G
A
E
N
L
R
I
L
I
S
D
F
G
L
C
K
K
L
D
S
T
S
G
W
R
A
P
E
L
L
----
E
E
S
N
N
L
Q
T
K
R
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
F
G
D
K
Y
S
R
E
S
N
I
I
R
----
G
I
F
S
L
D
E
M
K
C
L
H
D
R
S
L
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
P
S
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
D
W
T
V
K
F
D
K
T
F
M
D
R
K
Y
H
S
S
-------------
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
-----
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
NLSDD
Q
I
L
R
E
F
L
YS
9
PsiBlast_PDB
60.64
44%
-128
- C1 -
-
5LQF
1
CDK1_HUMAN
A:
[9-158]
--------------------------------------------------------------------
Y
T
K
I
E
K
I
G
E
G
T
Y
G
-
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
-
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
-
D
S
R
L
Y
L
I
F
E
F
L
S
-
M
D
L
K
K
Y
L
D
S
I
-
P
-
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
---
L
Y
-
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
DKG
T
I
K
L
A
D
F
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
60.58
48%
-106
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[3-135]
-------------------------------------------------------------------
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
-
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
-
K
H
K
N
I
V
R
L
H
D
V
L
H
S
-
D
K
K
L
T
L
V
F
E
F
C
D
-
Q
D
L
K
K
Y
F
D
S
C
-
N
-
G
D
-
L
D
P
E
I
-
V
K
S
F
---
L
F
-
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
59.95
27%
-65
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-212]
----------------------------------------------------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
-
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
-
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
Y
S
E
A
D
A
S
H
C
---
I
Q
-
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
----
S
K
S
------------------------------------------------------------------
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
-
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.62
44%
-127
- C1 -
-
5HQ0
1
CDK1_HUMAN
A:
[9-153]
--------------------------------------------------------------------
Y
T
K
I
E
K
I
G
E
G
T
Y
G
-
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
-
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
-
D
S
R
L
Y
L
I
F
E
F
L
S
-
M
D
L
K
K
Y
L
D
S
I
-
P
-
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
---
L
Y
-
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
DKG
T
I
K
L
A
D
F
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
59.62
44%
-127
- C1 -
-
4Y72
1
CDK1_HUMAN
A:
[9-153]
--------------------------------------------------------------------
Y
T
K
I
E
K
I
G
E
G
T
Y
G
-
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
-
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
-
D
S
R
L
Y
L
I
F
E
F
L
S
-
M
D
L
K
K
Y
L
D
S
I
-
P
-
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
---
L
Y
-
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
DKG
T
I
K
L
A
D
F
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
57.85
48%
-113
- C1 -
-
4AU8
1
CDK5_HUMAN
A:
[7-141]
-------------------------------------------------------------------
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
-
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
-
K
H
K
N
I
V
R
L
H
D
V
L
H
----
K
L
T
L
V
F
E
F
C
D
-
Q
D
L
K
K
Y
F
D
S
C
-
N
-
G
D
-
L
D
P
E
I
-
V
K
S
F
---
L
F
-
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
57.55
42%
-112
- C1 -
-
2IW8
1
CDK2_HUMAN
A:
[8-151]
--------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
-
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
-
N
H
P
N
I
V
K
L
L
D
V
I
H
T
-
E
N
K
L
Y
L
V
F
E
H
V
D
-
Q
D
L
K
K
F
M
D
A
S
-
A
-
L
T
G
I
P
L
P
L
-
I
K
S
Y
---
L
F
-
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
TEG
A
I
K
L
A
D
F
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
57.29
48%
-122
- C1 -
-
1UNG
1
CDK5_HUMAN
A:
[3-135]
-------------------------------------------------------------------
K
Y
E
K
L
E
K
I
----
Y
G
-
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
-
K
H
K
N
I
V
R
L
H
D
V
L
H
S
-
D
K
K
L
T
L
V
F
E
F
C
D
-
Q
D
L
K
K
Y
F
D
S
C
-
N
-
G
D
-
L
D
P
E
I
-
V
K
S
F
---
L
F
-
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
51.32
42%
-46
- C1 -
-
4KRC
1
PHO85_YEAST
A:
[2-145]
---------------------------------------------------------------
S
S
S
S
Q
F
K
Q
L
E
K
L
G
N
G
T
Y
A
-
T
V
Y
K
G
L
N
K
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
S
E
-
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
-
K
H
E
N
I
V
R
L
Y
D
V
I
H
T
-
E
N
K
L
T
L
V
F
E
F
M
D
-
N
D
L
K
K
Y
M
D
S
R
T
P
-
R
G
L
---
E
L
N
L
V
K
Y
---
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
----
K
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
48.03
42%
-116
- C1 -
-
3GC0
1
?
A:
[32-180]
----------------------------------------------------------------
S
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
-
E
V
Y
K
A
I
D
T
V
T
N
E
T
V
A
I
K
R
I
R
L
E
H
-------
T
A
I
R
E
V
S
L
L
K
E
L
-
Q
H
R
N
I
I
E
L
K
S
V
I
H
H
-
N
H
R
L
H
L
I
F
E
Y
A
E
-
N
D
L
K
K
Y
M
D
K
N
-
P
-------
D
V
S
M
R
V
I
K
S
F
L
Y
-
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
----
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------