@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_17_0070: (2018-03-09 )
MDFYALQDTLLRNAKSGGSSDTVDVESRYVLMEKIGSGSYGDVWSATRRTGTKDIYAVKRIDKRQAGTKGLRSVMGEVETMSLLSHPNIVKLEETYQDEACLSIVMEYLPGGSLQHRIDRQNVSELETRRFITQLLMAVEYIHEKGIVHRDLKPSNCLLSQNDLVVKISDFGLSVFAGNKQCLTTCCGTLHFMAPEILLEKNYGKPVDMWAMGVMAHVMFLGRYPFQARTEAALTKDICRGYRPREEGGGGLRCPPLLQDFISQLLLYDPLRRMSAKDALKHPWIKEGLDANRRTSLYPSQAPSATAMKPSARWRAAALAVMGVQRLLYLQKIQRLVRLGYDGFPILRDYRYLVTGKYVPASTSVECSHMFHARPMALLELISMIDTCPFLKHVDLSWNNIHSLSVIQALLKVVTRHPSLQSIDLSHNPIPAVAGRSIVRLIRNPLSQVTCINVGDTGISADTIGQINSFLKEKLTPAALSYSVSTGDMQSRLTQGSGDDTLMTSSSTTVSSLQQKRSICSGPPKQPAKKESRGVRLPPISRPPVARRHGKMP
Atome Classification :
(20 SA)
.......--..10........20........30........40........50........60......-------..70........80....-....90........100.......110..-....--.-120.-----........130.......140.......150.......--160.--.--......--.170.......180........190.......------200-.........210.......220....-...230.......240-------........250.......260.......270.......280...--....290...-....300.......310-.......--..320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MD
F
Y
A
L
Q
--
D
T
L
L
R
N
AKSGGSSD
T
V
D
V
E
S
R
Y
V
L
M
E
K
IGSGSYG
D
V
W
S
A
TRRTGT
K
D
I
Y
A
V
K
R
I
D
K
R
QA
G
-------
T
K
G
L
R
S
V
M
G
E
V
E
T
M
S
L
LS-HP
N
I
V
K
L
E
E
T
YQ
D
E
A
C
L
S
I
V
M
E
YLPGG
S
L
-
Q
H
R
I
--
D
-
R
--
Q
-----
N
V
S
E
L
E
T
R
R
F
I
T
Q
L
L
M
A
V
E
Y
I
H
EKG
I
V
HRDLKPSN
C
L
L--S--Q--N--
D
L
V
V
K
I
--SDF
G
L
S
V
FAG
N
K
Q
-
C
L
T
T
C
C
G
T
L
H
FM
A
P
E
I
L
L------E---KNYGK
P
V
D
M
W
A
M
G
V
M
A
H
V
M
F
L
GRYPF-QAR
T
E
A
A
L
T
K
D
I
C
RG--------YRPREEGGGGLRC
P
P
L
L
Q
D
F
I
S
Q
L
L
L
Y
D
P
L
R
R
M
S
A
K
D
A
LKH
P
W
I
--KEGLDANRRT-SLYPSQAPSATAMKP---SA
R
W
R
A
A
--
A
L
A
V
M
G
V
Q
R
L
L
Y
L
Q
K
I
Q
R
L
V
R
LGYDGF
P
I
L
R
D
Y
R
Y
L
V
TGKYVPASTSV
E
C
S
HMFHA
R
P
M
A
L
L
E
L
I
S
M
I
D
TCP
F
L
KHVDLSWNNI
H
S
L
S
V
I
Q
A
L
L
K
V
V
TRHPSL
Q
S
IDLSHNPI
P
A
V
A
G
R
S
I
V
R
L
I
RNPLS
Q
V
T
C
I
NVGDTGISA
D
T
I
G
Q
I
N
S
F
L
K
EKLT
P
A
A
L
S
Y
SVST
G
D
M
Q
S
R
LTQGSGDD
T
L
MTSSS
T
T
V
S
S
L
Q
Q
K
R
S
ICSGPPKQPAKKESRGVRLPPISRPP
V
A
R
RHGKMP
37
HHSearch
79.48
31%
-46
- C1 -
-
3KK8
-
KCC2D_CAEEL
A:
[3-269]
-------------------------
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
-
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
-------
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
Q
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
--
V
A
R
--
E
-----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
--
A
--
S
--
K
AK
G
A
A
V
K
L
--
A
D
F
G
L
A
I
E
V
N
D
S
E
-
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
---
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
--------
A
Y
D
Y
P
S
P
E
W
-
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
--
C
N
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.35
34%
-25
- C1 -
-
3LIJ
1
?
A:
[39-339]
------------------------------
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
-
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
------------
S
S
N
S
K
L
L
E
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
--
H
-
R
--
M
-----
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
SK
E
--
K
--
D
A
L
I
K
I
--
V
D
F
G
L
S
A
V
F
E
N
Q
K
-
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
-
L
------
R
---
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
-
G
G
Q
T
D
Q
E
I
L
R
K
V
E
K
G
KYTFDSPE
W
K
N
V
S
E
G
A
---------
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
--
K
E
M
C
S
K
K
E
S
----
L
P
S
L
A
N
A
I
E
N
M
R
K
F
QN
S
Q
K
L
A
Q
A
--
A
L
L
Y
M
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.79
35%
-43
- C1 -
-
4FG8
1
KCC1A_HUMAN
A:
[15-290]
-------------------------
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
-
T
Q
K
L
V
A
I
K
C
I
A
K
E
------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
-
E
-
K
--
G
-----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
SL
D
--
E
--
D
S
K
I
M
I
--
S
D
F
------------------
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
--------
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
AG
D
T
A
L
D
K
N
I
H
Q
-
S
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.95
35%
-57
- C1 -
-
4FG7
1
KCC1A_HUMAN
A:
[15-277]
-------------------------
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
-
T
Q
K
L
V
A
I
K
C
I
A
-----------------
S
M
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
-
E
-
K
--
G
-----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
SL
D
--
E
--
D
S
K
I
M
I
--
S
D
F
G
L
S
K
M
E
D
P
G
---------
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
--------
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.84
33%
-26
- C1 -
-
2JC6
1
KCC1D_HUMAN
A:
[19-314]
-------------------------
D
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
-
A
T
G
K
L
F
A
V
K
C
I
P
K
K
A
-------------
S
S
I
E
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
-
E
-
K
--
G
-----
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
--
S
--
Q
--
D
E
E
S
K
I
M
I
S
---------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
S
K
L
F
E
Q
I
L
K
A
--------
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
--
A
G
D
T
A
L
N
K
---
N
I
H
E
S
V
S
A
Q
I
R
K
N
F
A
---
K
S
K
W
R
Q
A
F
N
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
75.55
32%
-10
- C1 -
-
2PHK
2
PHKG1_RABIT
A:
[2-276]
--------------------------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
-
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
G
SFS
A
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
-
F
D
Y
L
--
T
E
K
--
V
-----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
--
D
-----
D
M
N
I
K
L
--
T
D
F
G
F
S
C
Q
L
D
P
G
E
-
K
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
DN
H
---
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
-
W
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
--------
N
Y
Q
F
G
S
P
E
W
-
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
--
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.78
35%
-30
- C1 -
-
2JAM
3
KCC1G_HUMAN
A:
[6-290]
-------------------------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
-
T
G
K
L
F
A
L
K
C
I
K
K
S
---------------
S
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
L
-
E
-
R
--
G
-----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
LT
P
--
E
--
E
--
N
S
K
I
M
I
--
T
D
F
G
L
S
K
M
E
Q
N
G
--
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
-
Y
E
E
T
E
S
K
L
F
E
K
I
K
E
G
--------
Y
Y
E
F
E
S
P
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
---
D
G
N
T
A
L
H
R
--
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
---
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
74.08
32%
-29
* C1 *
-
3C0I
1
CSKP_HUMAN
A:
[20-294]
------------------------
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
-
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP----
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
-
C
F
E
I
--
V
-
K
--
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
--
S
--
K
EN
S
A
P
V
K
L
--
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
-
Y
G
T
K
E
-
R
L
F
E
G
I
I
K
G
--------
K
Y
K
M
N
P
R
Q
W
-
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
--
K
E
R
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
73.52
30%
-37
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[5-275]
-----------------------
S
T
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
-
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
-------
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
Q
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
--
V
A
R
--
E
-----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
--
A
--
S
--
K
AK
G
A
A
V
K
L
--
A
D
F
G
L
A
I
E
V
N
D
S
E
-
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
---
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
--------
A
Y
D
Y
P
S
P
E
W
-
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
--
C
N
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.02
33%
-43
- C1 -
-
1A06
-
KCC1A_RAT
A:
[15-316]
-------------------------
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
-
T
Q
K
L
V
A
I
K
C
I
A
K
------------------
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
-
E
-
K
--
G
-----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
SL
D
--
E
--
D
S
K
I
M
I
--
S
D
F
-------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
--------
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
AG
D
T
A
L
D
K
N
-----
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
---
K
S
K
W
K
Q
A
--
F
N
A
T
A
V
V
R
H
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
71.47
32%
-20
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[19-294]
-----------------------
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
-
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP----
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
-
C
F
E
I
--
V
-
K
--
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
--
S
--
K
EN
S
A
P
V
K
L
--
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
-
Y
G
T
K
E
-
R
L
F
E
G
I
I
K
G
--------
K
Y
K
M
N
P
R
Q
W
-
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
--
K
E
R
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.44
33%
-29
- C1 -
-
2YCF
1
CHK2_HUMAN
A:
[11-300]
-----------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
-
A
I
K
I
I
S
K
----------------
N
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V-
G
-
N
--
K
-----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
--
S
SQ
E
--
E
--
D
C
L
I
K
I
--
T
D
F
G
H
S
K
I
L
G
E
T
S
-
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K-------
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
--
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
--
Q
D
E
-
D
M
K
R
K
F
-
Q
D
L
L
S
E
E
N
E
S
T
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
71.42
31%
-22
- C1 -
-
1KOB
1
?
A:
[48-312]
-------------------------
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
-
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
---------
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
-
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
-
F
D
R
I
--
A
-
A
ED
Y
-----
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
--
E
--
T
--
K
K-
A
S
S
V
K
I
--
I
D
F
G
L
A
T
K
L
N
P
D
E
-
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
---
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
-
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
--------
D
W
E
F
D
E
D
A
F
-
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
--
K
G
D
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.55
33%
-35
- C1 -
-
4FG9
1
KCC1A_HUMAN
A:
[15-314]
-------------------------
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
-
T
Q
K
L
V
A
I
K
C
I
A
K
E
-----------------
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
-
E
-
K
--
G
-----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
SL
D
--
E
--
D
S
K
I
M
I
--
S
D
F
-------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
--------
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
AG
D
T
A
L
D
K
N
-----
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
---
K
S
K
W
K
Q
A
--
F
N
A
T
A
V
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.96
33%
-33
- C1 -
-
2CN5
1
CHK2_HUMAN
A:
[17-302]
-----------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
-
A
I
K
I
I
S
K
R
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V-
G
-
N
--
K
-----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
--
S
SQ
E
--
E
--
D
C
L
I
K
I
--
T
D
F
G
H
S
K
I
L
G
E
T
S
-
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K-------
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
--
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
--
Q
D
E
-
D
M
K
R
K
F
-
Q
D
L
L
S
E
E
N
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.02
33%
-
- C1 -
-
4FGB
-
KCC1A_HUMAN
A:
[15-299]
-------------------------
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
-
T
Q
K
L
V
A
I
K
C
I
A
K
----------------
S
M
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
-
E
-
K
--
G
-----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
SL
D
--
E
--
D
S
K
I
M
I
--
S
D
F
G
L
S
K
M
E
D
P
G
S
-
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
--------
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
AG
D
T
A
L
D
K
N
-----
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
68.60
29%
-50
- C1 -
-
5IG1
-
?
A:
[15-280]
--------------------------
D
V
D
L
K
D
K
R
S
V
I
G
K
G
A
F
S
T
V
H
R
C
V
N
-
K
R
T
G
E
V
C
A
V
K
V
I
A
L
K
S
L
R
-------
S
S
E
I
N
K
I
K
R
E
I
G
I
C
S
S
L
Q
-
H
E
H
I
V
S
M
R
R
A
F
R
D
E
S
H
F
Y
L
V
F
E
Y
V
S
G
G
E
L
-
F
D
E
I
--
V
T
R
--
K
-----
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
N
I
I
H
R
D
L
K
P
E
N
L
L
L
--
A
--
S
KD
P
--
N
A
P
V
K
I
--
T
D
F
G
L
A
V
I
M
E
Q
G
P
-
T
Y
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
I
R
------
R
---
V
P
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
E
E
D
H
Q
K
L
Y
A
Q
I
K
N
C
--------
Q
Y
D
F
P
S
P
E
W
-
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
R
P
T
V
Q
E
L
L
Q
H
P
W
I
--
A
R
R
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
68.19
25%
31
- C1 -
-
1KOB
1
?
A:
[23-374]
I
N
D
Y
D
K
F
YE
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
-
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
---------
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
-
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
-
F
D
R
I
A
A
E
-
D
--
Y
-----
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E-
T
--
K
--
K
--
A
S
S
V
K
I
--
I
D
F
G
L
A
T
K
L
N
P
D
E
-
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
---
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
-
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
--------
D
W
E
F
D
E
D
A
F
S
-
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
--
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
---
Y
A
D
W
P
A
P
--
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
67.76
31%
-36
- C1 -
-
4MVF
2
CDPK2_PLAFK
A:
[55-357]
--------------------------
L
E
D
K
Y
I
I
D
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
-
T
N
Q
L
Y
A
I
K
--
E
E
K
K
D
R
-------
L
K
N
I
N
R
F
F
Q
E
I
E
I
M
K
K
L
D
-
H
P
N
I
V
K
L
Y
E
T
Y
E
N
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
I
--
E
-
N
--
G
-----
S
F
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
F
Q-
S
--
E
--
N
K-
D
S
L
L
K
I
--
I
D
F
G
L
S
K
N
L
----------------------------------
K
Y
D
K
K
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
-
Y
-----------------------
C
F
Y
E
N
D
W
G
S
I
S
S
D
A
--
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
T
I
E
E
A
L
N
H
P
W
I
--
T
Q
M
T
K
S
--
H
V
-
E
L
S
S
T
L
L
K
N
L
K
N
F
K
K
---
E
N
E
L
K
K
I
--
A
L
T
I
I
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
67.00
34%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[2-271]
--------------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
-
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
-------
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
--
V
A
R
--
E
-----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
--
S
--
K
SK
G
A
A
V
K
L
--
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
--------
A
Y
D
F
P
S
P
E
W
-
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
--
C
Q
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------